SA520411120B1 - مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات - Google Patents
مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركباتInfo
- Publication number
- SA520411120B1 SA520411120B1 SA520411120A SA520411120A SA520411120B1 SA 520411120 B1 SA520411120 B1 SA 520411120B1 SA 520411120 A SA520411120 A SA 520411120A SA 520411120 A SA520411120 A SA 520411120A SA 520411120 B1 SA520411120 B1 SA 520411120B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- preparing
- same
- aminopyrimidine derivatives
- intermediates useful
- novel intermediates
- Prior art date
Links
- 150000005005 aminopyrimidines Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000543 intermediate Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108060006633 protein kinase Proteins 0.000 abstract 2
- 102000001301 EGF receptor Human genes 0.000 abstract 1
- 108060006698 EGF receptor Proteins 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
Abstract
يوفر الاختراع الحالي عملية محسّنة لتحضير مشتقات أمينو بيريميدين أو أملاح منه مقبولة صيدلانيًا تتميز بنشاط تثبيطي انتقائي ضد كينازات البروتين، وخاصة ضد كينازات البروتين لمستقبلات عوامل النمو البشروية الطافرة. ويوفر الاختراع الحالي أيضًا مركبات وسيطة جديدة مفيدة للعملية المذكورة ولعمليات من أجل تحضيرها.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096220 | 2017-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520411120B1 true SA520411120B1 (ar) | 2022-08-25 |
Family
ID=65040817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520411120A SA520411120B1 (ar) | 2017-07-28 | 2020-01-22 | مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10858353B2 (ar) |
| EP (1) | EP3658553B1 (ar) |
| JP (1) | JP7216704B2 (ar) |
| KR (1) | KR102684954B1 (ar) |
| CN (1) | CN111032650A (ar) |
| AU (1) | AU2018308039B2 (ar) |
| CA (1) | CA3069408A1 (ar) |
| CO (1) | CO2020000595A2 (ar) |
| CY (1) | CY1125473T1 (ar) |
| DK (1) | DK3658553T3 (ar) |
| EA (1) | EA038856B1 (ar) |
| ES (1) | ES2923278T3 (ar) |
| HR (1) | HRP20220848T1 (ar) |
| HU (1) | HUE059501T2 (ar) |
| IL (1) | IL271974B (ar) |
| LT (1) | LT3658553T (ar) |
| MA (1) | MA49703A (ar) |
| MX (1) | MX394027B (ar) |
| MY (1) | MY200829A (ar) |
| PH (1) | PH12020500070A1 (ar) |
| PL (1) | PL3658553T3 (ar) |
| PT (1) | PT3658553T (ar) |
| RS (1) | RS63497B1 (ar) |
| SA (1) | SA520411120B1 (ar) |
| SG (1) | SG11201913520YA (ar) |
| SI (1) | SI3658553T1 (ar) |
| SM (1) | SMT202200291T1 (ar) |
| UA (1) | UA125664C2 (ar) |
| WO (1) | WO2019022486A1 (ar) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3658552T3 (da) | 2017-07-28 | 2023-11-20 | Yuhan Corp | Fremgangsmåde til fremstilling af n-(5-((4-(4-((dimethylamino)methyl)-3-phenyl-1h-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamid ved reaktion af den tilsvarende amin med et 3-halogen-propionylchlorid |
| PH12021552798A1 (en) | 2019-05-14 | 2022-09-19 | Janssen Biotech Inc | Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
| JOP20220184A1 (ar) | 2020-02-12 | 2023-01-30 | Janssen Biotech Inc | علاج مصابي السرطان ممن لديهم طفرات تخطي c-Met إكسون14 |
| TW202207940A (zh) | 2020-04-14 | 2022-03-01 | 美商健生生物科技公司 | 包含胺基嘧啶衍生物或其醫藥上可接受之鹽、水合物、或溶劑化物之用於經口投予之醫藥組成物 |
| CA3228195A1 (en) | 2023-05-23 | 2025-06-30 | Janssen Biotech, Inc. | Methods for treatment of non-small cell lung cancer (nsclc) |
| WO2025052273A1 (en) | 2023-09-05 | 2025-03-13 | Janssen Biotech, Inc. | Methods of treating non-small cell lung cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ599041A (en) * | 2009-11-13 | 2014-05-30 | Genosco | Kinase inhibitors |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| HRP20250213T1 (hr) * | 2014-10-13 | 2025-04-25 | Yuhan Corporation | Spojevi i pripravci za modulaciju aktivnosti egfr mutantne kinaze |
| CN104788427B (zh) | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| JP6457697B2 (ja) * | 2015-04-29 | 2019-01-23 | カントン チョンション ファーマシューティカル カンパニー，リミティド | キナーゼ阻害剤としての縮合環式または三環式アリールピリミジン化合物 |
| WO2017027768A1 (en) * | 2015-08-13 | 2017-02-16 | The Broad Institute, Inc. | Compositions and methods for treating tuberculosis |
| PT3658547T (pt) * | 2017-07-28 | 2023-10-20 | Yuhan Corp | Processo de preparação de n -(5 -(4 -(4 -formil -3- fenil- 1h -pirazol- 1 -il)pirimidin -2- ilamino) -4 -metoxi 2- morfolinofenil) acrilamida |
-
2018
- 2018-07-25 HU HUE18838173A patent/HUE059501T2/hu unknown
- 2018-07-25 IL IL271974A patent/IL271974B/en unknown
- 2018-07-25 SI SI201830722T patent/SI3658553T1/sl unknown
- 2018-07-25 WO PCT/KR2018/008381 patent/WO2019022486A1/en not_active Ceased
- 2018-07-25 MX MX2020001047A patent/MX394027B/es unknown
- 2018-07-25 EA EA202090385A patent/EA038856B1/ru unknown
- 2018-07-25 US US16/633,695 patent/US10858353B2/en active Active
- 2018-07-25 DK DK18838173.5T patent/DK3658553T3/da active
- 2018-07-25 PL PL18838173.5T patent/PL3658553T3/pl unknown
- 2018-07-25 KR KR1020180086377A patent/KR102684954B1/ko active Active
- 2018-07-25 JP JP2020503944A patent/JP7216704B2/ja active Active
- 2018-07-25 SG SG11201913520YA patent/SG11201913520YA/en unknown
- 2018-07-25 CA CA3069408A patent/CA3069408A1/en active Pending
- 2018-07-25 MA MA049703A patent/MA49703A/fr unknown
- 2018-07-25 SM SM20220291T patent/SMT202200291T1/it unknown
- 2018-07-25 UA UAA202001305A patent/UA125664C2/uk unknown
- 2018-07-25 PT PT188381735T patent/PT3658553T/pt unknown
- 2018-07-25 ES ES18838173T patent/ES2923278T3/es active Active
- 2018-07-25 EP EP18838173.5A patent/EP3658553B1/en active Active
- 2018-07-25 HR HRP20220848TT patent/HRP20220848T1/hr unknown
- 2018-07-25 LT LTEPPCT/KR2018/008381T patent/LT3658553T/lt unknown
- 2018-07-25 AU AU2018308039A patent/AU2018308039B2/en active Active
- 2018-07-25 MY MYPI2020000439A patent/MY200829A/en unknown
- 2018-07-25 RS RS20220706A patent/RS63497B1/sr unknown
- 2018-07-25 CN CN201880049025.7A patent/CN111032650A/zh active Pending
-
2020
- 2020-01-09 PH PH12020500070A patent/PH12020500070A1/en unknown
- 2020-01-20 CO CONC2020/0000595A patent/CO2020000595A2/es unknown
- 2020-01-22 SA SA520411120A patent/SA520411120B1/ar unknown
-
2022
- 2022-08-05 CY CY20221100537T patent/CY1125473T1/el unknown
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