SA07280014B1 - Manufacturing process of solution based on Polyethyleneglycol With Electrolytes,Product Obtained and use - Google Patents
Manufacturing process of solution based on Polyethyleneglycol With Electrolytes,Product Obtained and use Download PDFInfo
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- SA07280014B1 SA07280014B1 SA7280014A SA07280014A SA07280014B1 SA 07280014 B1 SA07280014 B1 SA 07280014B1 SA 7280014 A SA7280014 A SA 7280014A SA 07280014 A SA07280014 A SA 07280014A SA 07280014 B1 SA07280014 B1 SA 07280014B1
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- 239000002202 Polyethylene glycol Substances 0.000 title claims abstract description 17
- 229920001223 polyethylene glycol Polymers 0.000 title claims abstract description 17
- 239000003792 electrolyte Substances 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- 238000010348 incorporation Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 8
- 238000004090 dissolution Methods 0.000 claims description 7
- 239000008141 laxative Substances 0.000 claims description 7
- 230000002475 laxative effect Effects 0.000 claims description 7
- 235000003599 food sweetener Nutrition 0.000 claims description 5
- 230000000968 intestinal effect Effects 0.000 claims description 5
- 230000003204 osmotic effect Effects 0.000 claims description 5
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 5
- 235000011152 sodium sulphate Nutrition 0.000 claims description 5
- 239000003765 sweetening agent Substances 0.000 claims description 5
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 4
- 239000008213 purified water Substances 0.000 claims description 4
- 206010010774 Constipation Diseases 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000008119 colloidal silica Substances 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- 239000001103 potassium chloride Substances 0.000 claims description 2
- 235000011164 potassium chloride Nutrition 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 23
- 239000000203 mixture Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 235000019568 aromas Nutrition 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 229940124382 agent for constipation Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000002052 colonoscopy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000819 hypertonic solution Substances 0.000 description 1
- 229940021223 hypertonic solution Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Conductive Materials (AREA)
- Primary Cells (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
الملخص: عملية تصنيع متعدد إيثيلين جيكول Polyethyleneglycol مع اليكتروليتات electrolytes ، عن طريق العملية المذكورة يحصل على منتج أساسه متعدد إيثيلين جليكول Polyethyleneglycol و اليكتروليتات electrolytes في حالة هلام gel تعرض ذوبانية Solubility أكبر و بذلك يسهل امتصاصها ، خصائص حالة عضويا محسنة و متاحية أكبر في الكائن العضوي Organism .Abstract: The process of manufacturing Polyethyleneglycol with electrolytes, by means of the aforementioned process a product based on Polyethyleneglycol is obtained and the electrolytes in the case of a gel display greater solubility, thus facilitating absorption, improved organic state properties and greater availability in the organism Organism.
Description
عملية تصنيع محلول مكون بصفة أساسية من متعدد إيثيلين جليكول بواسطة اليكتروليتات « mile محصل و استعمالاته Manufacturing process of solution based on Polyethyleneglycol With Electrolytes,Product Obtained and use الوصف الكاملManufacturing process of solution based on Polyethyleneglycol With Electrolytes,Product Obtained and use Full description
خلفية الاختراعInvention background
كما ذكر في العنوان لهذه المواصفة ¢ فإن الاختراع الحالي يختص بعملية تصنيعAs stated in the title of this specification ¢ the present invention relates to a manufacturing process
manufacturing process محلول Solution أساسه متعدد إيثيلين جليكولmanufacturing process Solution based on polyethylene glycol
polyethyleneglycol اليكتروليتات «electrolytes المنتج المحصل و استعماله عنpolyethyleneglycol electrolytes “electrolytes” the obtained product and its use for
© طريق هذه العملية المنتج المحصل المكون أساسا من متعدد إيثيلين جليكول© Through this process, the obtained product consisting mainly of polyethylene glycol
polyethyleneglycol و اليكتروليتات electrolytes في حالة الهلام gel يعرض ذوبانيةpolyethyleneglycol and electrolytes in the gel state displays solubility
Solubility أكبر و بذلك Jew امتصاصه ؛ خصائص حالة عضوياً organoleptic محسنةSolubility is greater and thus the absorption of Jew; Organically improved state of organoleptic properties
و متاحية availability أكبر في الكاثئن Organism (g gual .Availability is greater in Organism (g gual .
هذه المواصفة تصف طريقة تصنيع محلول أساسه متعدد إيثيلين جليكول و اليكتروليتات ؛ Ve المنتج المحصل المتضمن على التطبيق كمسسهل أسموزي osmotic laxative لعلاجThis standard describes a method for manufacturing a polyethylene glycol-based solution and electrolytes; Ve, the obtained product included in the application as an osmotic laxative for the treatment of
الإمساك constipation ¢ و مادة تفريغ المعي intestinal evacuant للتحضير قبلConstipation ¢ and intestinal evacuant for preparation before
فحوصات القولون-المستقيم colorectal examinations تتناول عن طريق المسلك الفميColorectal examinations are taken orally
. Oral route,. Oral route
بنحو تقليدي ؛ المحاليل المصنوعة على أساس متعدد إيثيلين جليكول و اليكتروليتات تقدم Ve في صورة مسحوق powder form لكي تذاب في الماء dissolved in water تتناول عنtraditionally Solutions made on the basis of polyethylene glycol and electrolytes, Ve is presented in powder form to be dissolved in water.
Yyey v لعلاج osmotic laxative ؛ تستخدم كمادة مسهلة أسموزية oral route طريق المسلك الفمي للتحضير مثلاء intestinal evacuant و كمادة تفريغ المعي constipation الإمساك ؛ المعالجة بالأشضعة surgery ؛ الجراحة colonoscopy قبل الفحص المجهري للقولون و الجهاز البولي other colorectal الفحوصات الأأخرى للقولون-المستقيم radiology . genitourinary examinations التتاسلي © على متعدد إيثيلين جليكول و solutions based بهذه الطريقة ¢ المحاليل المعتمدة من المكونات homogeneous mixture اليكتروليتات تحضل عن طريق مخلوط متجانس لتذاب في powder product في صورة منتج مسحوق components resulting الناتجة . oral administration الماء للتناول الفمي على أساس متعدد powder solution لذلك ؛ يمكن أن نأخذ في الاعتبار محلول مسحوق ٠ -: سوف يقرب مما يلي weight يثيلين جليكول الذي تركيبه بالوزن المناظرة ؛ على سبيل المثال excipients إضافة إلى السواغات aroma -<روائح عطرية . sweetener مادة تحلية -Yyey v for osmotic laxative treatment; It is used as an osmotic laxative, oral route, by the oral route, to prepare an intestinal evacuant and as a bowel emptying agent for constipation; radiotherapy surgery; Surgery, colonoscopy, before microscopic examination of the colon and urinary system, other colorectal, other examinations of the colon-rectum, radiology. genitourinary examinations serially on polyethylene glycol and solutions based in this way ¢ approved solutions of homogeneous mixture electrolytes are prepared through a homogeneous mixture to dissolve in the powder product in the form of components resulting resulting. oral administration water for oral administration multi based powder solution therefore; We can take into account a powder solution of -0: it will approximate the following weight of ethylene glycol whose composition is by the corresponding weight; For example excipients in addition to the excipients aroma -< aromas. sweetener
YYeyYYey
¢ بإيجاز ¢ المحاليل الفمية المعتمدة على متعدد إيثيلين جليكول كعامل أسموزي osmotic agent و اليكتروليتات عبارة عن محاليل فائقة التقوية hypertonic solutions + وبتلك الطريقة هي تسهل خروج الماء exit of water تجاه تجويف المعي intestinal lumen و لذلك لديها تأثير Jerse / مفرغ laxative/ evacuant . © الوصف العام للاإختراع يهدف الاختراع الحالي الحصول على محلول مكون أساسيا من متعدد إيثيلين جليكول و اليكتروليتات ؛ في صورة عجنة تقنية technical batch من 0000 لتر ؛ المفاعل الرئيسي main reactor سوف يستخدم بسعة تساوي ٠٠٠١ لتر مزود بمقلب به مجداف paddle of stirrer وسيلة مماثلة similar و وسيلة تجانس homogenizer ؛ بالتوازي مع مفاعلات ٠ مساعدة along with some auxiliary reactors ¢ موازين لوزن المكونات balances for weighing out the components و آلية مناسبة appropriate machinery للجرعات 8 و إحكام القفل الأتوماتيكي automatic sealing لأوعية container vessels 4 sla . بهذه الطريقة ؛ أولا يضاف add جزء من الماء النقي some purified water للمفاعل ١٠ الرئيسي main reactor ¢ توصيل المقلب connecting the stirrer دمج incorporating ما يقرب من ٠.8 % من الوزن weight من العجنة of yall batch تحضيرها « تقليبها حتى الذوبان stirring until it has dissolved . لاحقا ¢ كل المواد الأساسية النشطة active principles سوف يتم إضافتها ¢ فيما عدا سلفات الصوديوم sodium sulphate ؛ واحدة بواحدة one by one و تقليب stirring كل “٠ واحدة قبل إضافة اللاحقة next is added ؛ بتلك الطريقة فإن تلك المواد الأساسية النشطة عبارة عن :-¢ Briefly ¢ Oral solutions based on polyethylene glycol as an osmotic agent and electrolytes are hypertonic solutions + in this way they facilitate the exit of water towards the intestinal lumen and therefore It has a jerse / laxative / evacuant effect. © General description of the invention The present invention aims to obtain a solution composed mainly of polyethylene glycol and electrolytes; In the form of a technical batch of 0000 liters; The main reactor will be used with a capacity of 0001 liters equipped with a paddle of stirrer, similar method and homogenizer; Along with some auxiliary reactors ¢ balances for weighing out the components appropriate machinery for dosing 8 and automatic sealing for container vessels 4 sla. this way ; First add some purified water to the main reactor 10 ¢ connecting the stirrer incorporating approximately 0.8% by weight From the dough, of yall batch, preparing it «stirring until it has dissolved. Later ¢ all active principles will be added ¢ except for sodium sulphate; one by one and stirring every “0” before adding the suffix next is added ; In this way, those active basic materials are:
%Y o— من الوزن weight من المحلول المراد تحضيره solution to be prepared ¢ من متعدد إيثيلين جليكول polyethyleneglycol ¢ Y= % من الوزن weight للمحلول المراد تحضيره to be prepared 80101100 من بيكربونات الصوديوم sodium bicarbonate ¢ A= © + 96 من الوزن weight للمحلول J yall تحضيره solution to be prepared ¢ مسن كلوريد الصوديوم sodium chloride ¢ -€0 .+ % من الوزن weight للمحلول yall 3 تحضيره solution to be prepared ¢ من كلوريد البوتاسيوم potassium chloride,and s¢ Y= % من الوزن weight للمحلول J yall تحضيره solution to be prepared ¢ مسن ٠ بيفوسفات الصوديوم sodium biphosphate ¢ تلك النسب المئوية percentages ¢ بالطبع ؛ تمثل بكميات تقريبية approximately quantities . متى يتم تجانس المخلوط ¢ Yo ١.48 من الوزن للعجنة في المحلول المراد تحضيره ؛ من مواد التحلية تضاف sweeteners are added ¢ التقليب stirring حتى الإذابة until dissolution ٠ . فوق ذلك ؛ في مفاعل مساعد auxiliary reactor سعته ١5١ لتر 6 6.2 % من الوزن للعجنة في المحلول تحضر ؛ من مواد عطرية برتقالية اللون orange aroma تذاب ٠٠١ dissolved لتر ( تقريبا 967 من العجنة المراد تحضيرها ) من الماء النقي ؛ المخلوط ومن ثم يضاف للمفاعل الرئيسي ؛ ٠ بالمثل ؛ في وعاعين vessels أو مفاعلين مساعدين auxiliary reactors » نصف الكمية من هيدروكسي إيثيل سليللوز half of the hydroxyethylcellulose ¢ بمعاني أخرى ؛ تقريبا Yyey%Y o— of the weight of the solution to be prepared ¢ of polyethyleneglycol ¢ Y= % of the weight of the solution to be prepared 80101100 sodium bicarbonate ¢ A = © + 96 by weight of the J yall solution to be prepared ¢ sodium chloride aged ¢ -€0 + % by weight 3 yall solution to be prepared ¢ of potassium chloride,and s¢ Y = % weight of J yall solution to be prepared ¢ aged 0 sodium biphosphate – those percentages – of course; It represents approximately quantities. When the mixture is homogenized ¢ Yo 1.48 of the weight of the dough in the solution to be prepared; Sweeteners are added from sweeteners ¢ Stirring until dissolved until dissolution 0 . on top of that ; In an auxiliary reactor with a capacity of 151 liters 6 6.2% of the weight of the dough in the solution is prepared; of orange aromas dissolved in 100 liters (approximately 967 of the dough to be prepared) of pure water; mixture and then added to the main reactor; 0 likewise; in two vessels or auxiliary reactors » half of the hydroxyethyl cellulose ¢ in other words; Almost yeah
< 8 % من الوزن للمحلول المراد تحضيره ؛ و نصف من سلفات الصوديوم اللامائية half of the anhydrous sodium sulphate ¢ بمعاني أخرى V1 % من الوزن للمحلول المراد تحضيره ؛ تخلطان في بعضهم البعض ؛ ومن ثم تضاف للمفاعل الرئيسي ¢ بطريقة ما بحيث أنه أولا المحتويات في أحد الأوعية one of the vessels تستقدم ؛ و متى أذيبت ؛ المحتويات للوعاء الثاني second vessel تستقدم بعد ذلك . لذلك ؛ فإن دمج هيدروكسي إيثيل سليللوز hydroxyethylcellulose و سلفات الصوديوم اللامائية anhydrous sodium sulphate يسبب أن المحلول المحصل solution obtained ) المنتج) ) fay (product في تماسك الهلام consistency of a gel . أخيرا » فإن الدمج البطيء slow incorporation سوف يستمر عن طريق ما يقرب من 9©١ ٠ من الوزن للمحلول المراد تحضيره ؛ من سيليكا غروائنية colloidal silica و الماء purified water (il سوف يضاف لأجل كمية محصلة مقدرة سلفا أو عجنة ؛ أي ؛ ٠ لتر من المحلول المراد تحضيره. متى تم الحصول على العجنة من 200 لتر من المحلول المعتمد على متعدد إيثيلين جليكول و الاليكتروليتات في Alla الهلام (الجل) ؛ سوف تستمر في التجرع بطريقة ١٠ تقليدية في قوارير أو في أكياس أحادية الجرعة single-dose sachets ذات أحجام مختلفة different volumes . المنتج المحصل product obtained في صورة هلام يعرض درجة أس هيدروجيني pH ما بين ١ و 3.0 و لزوجة viscosity بين 300 ٠٠٠١ سنتي بواز ops ؛ وسوف تتناول عن طريق المسلك الفمي ؛ بطريقة معينة بحيث أن Alla الهلام تسهل من ذوبانيته its solubility | ٠ 18011118165 لكي يمتص absorbed بنحو أمثل عن طريق الكائن الحي Yyey< 8% by weight of the solution to be prepared; Half of the anhydrous sodium sulphate ¢ In other words, V1% of the weight of the solution to be prepared; they mix into each other; and then add to the main reactor ¢ in such a way that first the contents of one of the vessels are introduced; and when it was dissolved; The contents of the second vessel are then served. So ; The combination of hydroxyethylcellulose and anhydrous sodium sulphate causes that the solution obtained (product) fay (product) in the consistency of a gel. Finally, the slow incorporation slow incorporation will be carried on by means of approximately 9©1 0 by weight of the solution to be prepared; of colloidal silica and purified water (il) will be added for a predetermined amount of yield or knead; i.e.; 0 liters of the solution to be prepared Once the dough has been obtained from 200 liters of a solution based on polyethylene glycol and electrolytes in Alla gel ; it will continue to be dosed in the traditional 10 way in vials or in single-dose sachets single-dose sachets of different volumes The product obtained is in the form of a gel with a pH between 1 and 3.0 and a viscosity between 300,001 cP ops; and you will take it through the oral route; in a specific way so that Alla gel facilitates its solubility | 0 18011118165 in order to be optimally absorbed by the organism Yyey
organoleptic organism ؛ وهي تمثل متاحية أكبر في الكائن العضوي الحي و تتضمن على خصائص انحلال عضوي Jud better organoleptic organism . المنتج المحصل يحتوي على الاستعمال كمادة مسهلة أسموزية لعلاج الإمساك و مادة لتفريغ المع للتحضير قبل فحوصات القولون- المستقيم و الجهاز البولي التناسلي .organoleptic organism; It represents greater availability in the living organic organism and includes the characteristics of Jud better organoleptic organism. The obtained product contains for use as an osmotic laxative for the treatment of constipation and as a substance for bowel emptying for preparation before examinations of the colon-rectum and genitourinary system.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200600198A ES2278537B1 (en) | 2006-01-30 | 2006-01-30 | PROCEDURE FOR MANUFACTURING A SOLUTION BASED ON POLYETHYLENE GLYCOL WITH ELECTROLYTES, PRODUCT OBTAINED AND USE. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA07280014B1 true SA07280014B1 (en) | 2009-12-22 |
Family
ID=38308886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA7280014A SA07280014B1 (en) | 2006-01-30 | 2007-01-30 | Manufacturing process of solution based on Polyethyleneglycol With Electrolytes,Product Obtained and use |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES2278537B1 (en) |
| SA (1) | SA07280014B1 (en) |
| WO (1) | WO2007085676A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0913295D0 (en) | 2009-07-30 | 2009-09-02 | Norgine Bv | Improvements in and relating to pharmaceutical compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0231356A1 (en) * | 1985-08-01 | 1987-08-12 | Braintree Laboratories, Inc. | Low-sodium laxative and lavage formulation |
| US6946149B2 (en) * | 2002-04-30 | 2005-09-20 | Braintree Laboratories, Inc. | Salt solution for colon cleansing |
| GB0224909D0 (en) * | 2002-10-25 | 2002-12-04 | Norgine Europe Bv | Colon cleansing compositions |
| CA2546019A1 (en) * | 2003-11-17 | 2005-06-02 | Braintree Laboratories, Inc. | Therapeutic peg solution concentrate |
| GB0409104D0 (en) * | 2004-04-23 | 2004-05-26 | Norgine Europe Bv | Compressed pharmaceutical compositions |
-
2006
- 2006-01-30 ES ES200600198A patent/ES2278537B1/en active Active
-
2007
- 2007-01-29 WO PCT/ES2007/000043 patent/WO2007085676A1/en not_active Ceased
- 2007-01-30 SA SA7280014A patent/SA07280014B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2278537B1 (en) | 2008-09-16 |
| WO2007085676A1 (en) | 2007-08-02 |
| ES2278537A1 (en) | 2007-08-01 |
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