[go: up one dir, main page]

RU98116461A - COMPLEX 1- (2-HYDROXYETHYL) -2-METHYL-5-NITROMIDAZOLE WITH POLYVINYL PYRROLIDONE, METHOD FOR PRODUCING, PHARMACEUTICAL COMPOSITION HAVING ANTIMICROBIC ACTION - Google Patents

COMPLEX 1- (2-HYDROXYETHYL) -2-METHYL-5-NITROMIDAZOLE WITH POLYVINYL PYRROLIDONE, METHOD FOR PRODUCING, PHARMACEUTICAL COMPOSITION HAVING ANTIMICROBIC ACTION

Info

Publication number
RU98116461A
RU98116461A RU98116461/04A RU98116461A RU98116461A RU 98116461 A RU98116461 A RU 98116461A RU 98116461/04 A RU98116461/04 A RU 98116461/04A RU 98116461 A RU98116461 A RU 98116461A RU 98116461 A RU98116461 A RU 98116461A
Authority
RU
Russia
Prior art keywords
complex
hydroxyethyl
methyl
pharmaceutical composition
nitromidazole
Prior art date
Application number
RU98116461/04A
Other languages
Russian (ru)
Other versions
RU2157384C2 (en
Inventor
В.А. Лопырев
Л.Г. Розинова
Н.И. Процук
Е.Г. Григорьев
А.С. Коган
Э.Э. Кузнецова
А.В. Астахова
Б.В. Михалев
Н.В. Тарасов
А.В. Камышанов
Original Assignee
Иркутский институт химии СО РАН
Центр восстановительной и реконструктивной хирургии Восточно-Сибирского научного центра СО РАМН
ЗАО "АркЭлит"
Filing date
Publication date
Application filed by Иркутский институт химии СО РАН, Центр восстановительной и реконструктивной хирургии Восточно-Сибирского научного центра СО РАМН, ЗАО "АркЭлит" filed Critical Иркутский институт химии СО РАН
Priority to RU98116461A priority Critical patent/RU2157384C2/en
Priority claimed from RU98116461A external-priority patent/RU2157384C2/en
Publication of RU98116461A publication Critical patent/RU98116461A/en
Application granted granted Critical
Publication of RU2157384C2 publication Critical patent/RU2157384C2/en

Links

Claims (6)

1. Комплекс 1-(2-гидроксиэтил)-2-метил-5-нитроимидазола с поливинилпирролидоном молекулярной массы 9000 - 60000:
Figure 00000001

где n = 81-539.1. The complex of 1- (2-hydroxyethyl) -2-methyl-5-nitroimidazole with polyvinylpyrrolidone of molecular weight 9000 - 60,000:
Figure 00000001

where n = 81-539. 2. Способ получения комплекса формулы I, заключающийся в том, что 1-(2-гидроксиэтил)-2-метил-5-нитроимидазол подвергают взаимодействию с поливинилпирролидоном мол. мас. 9000 - 60000 в течение 6-12 ч. 2. The method of obtaining the complex of formula I, which consists in the fact that 1- (2-hydroxyethyl) -2-methyl-5-nitroimidazole is reacted with polyvinylpyrrolidone mol. wt. 9000 - 60,000 for 6-12 hours 3. Способ по п. 2, отличающийся тем, что взаимодействие осуществляют в водной среде, в течение 6 ч при температуре 60-70°С и при весовом соотношении компонентов 1:10. 3. The method according to p. 2, characterized in that the interaction is carried out in an aqueous medium, for 6 hours at a temperature of 60-70 ° C and with a weight ratio of components of 1:10. 4. Способ по п. 3, отличающийся тем, что полученный комплекс формулы I, дополнительно подвергают лиофильному высушиванию. 4. The method according to p. 3, characterized in that the resulting complex of formula I, is further subjected to freeze drying. 5. Способ по п. 2, отличающийся тем, что взаимодействие проводят в шаровой или Pulverisette мельнице в течение 12 ч и при весовом соотношении компонентов 1:10. 5. The method according to p. 2, characterized in that the interaction is carried out in a ball or Pulverisette mill for 12 hours and with a weight ratio of components of 1:10. 6. Фармацевтическая композиция, обладающая антимикробным действием, включающая активное соединение и фармацевтически приемлемую добавку, отличающаяся тем, что в качестве активного соединения она содержит соединение формулы I по п. 1 в эффективном количестве. 6. A pharmaceutical composition having an antimicrobial effect, comprising an active compound and a pharmaceutically acceptable additive, characterized in that as an active compound it contains a compound of formula I according to claim 1 in an effective amount.
RU98116461A 1998-08-27 1998-08-27 Complex of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole with polyvinylpyrrolidone, method of its preparing and pharmaceutical composition showing antibacterial effect RU2157384C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU98116461A RU2157384C2 (en) 1998-08-27 1998-08-27 Complex of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole with polyvinylpyrrolidone, method of its preparing and pharmaceutical composition showing antibacterial effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU98116461A RU2157384C2 (en) 1998-08-27 1998-08-27 Complex of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole with polyvinylpyrrolidone, method of its preparing and pharmaceutical composition showing antibacterial effect

Publications (2)

Publication Number Publication Date
RU98116461A true RU98116461A (en) 2000-04-27
RU2157384C2 RU2157384C2 (en) 2000-10-10

Family

ID=20210080

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98116461A RU2157384C2 (en) 1998-08-27 1998-08-27 Complex of 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole with polyvinylpyrrolidone, method of its preparing and pharmaceutical composition showing antibacterial effect

Country Status (1)

Country Link
RU (1) RU2157384C2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2205841C2 (en) * 2001-06-13 2003-06-10 Иркутский институт химии им. А.Е. Фаворского СО РАН Method of preparing complex of 1-(2'-hydroxyethyl)-2-methyl-5-nitroimidazole with polyvinylpyrrolidone
RU2220711C1 (en) * 2002-04-24 2004-01-10 Закрытое акционерное общество "Брынцалов-А" Antibacterial and antiprotozoan agent "trihobrol"
RU2310448C2 (en) * 2005-06-14 2007-11-20 Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук (ИрИХ СО РАН) Antibacterial pharmaceutical composition possessing prolonged effect
RU2304589C1 (en) * 2006-02-15 2007-08-20 Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук (ИрИХ СО РАН) Complex of polyvinylpyrrolidone and 2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-n-oxide (dioxydinum) and it using as antibacterial complex with prolonged effect

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US526217A (en) * 1894-09-18 brooks
SU1795646A1 (en) * 1990-03-06 1995-10-27 Иркутский институт органической химии СО АН СССР Complex of 2-acetylamino-5-nitrothiazole with polyvinylpyrrolidone showing antimicrobial activity with respect to nonspore-forming anaerobic infection
RU2061472C1 (en) * 1993-01-20 1996-06-10 Леонидов Николай Борисович Composition showing antimicrobial effect
RU2088234C1 (en) * 1994-11-25 1997-08-27 Институт высокомолекулярных соединений РАН Water-soluble bactericidal composition and a method of its preparing

Similar Documents

Publication Publication Date Title
WO2001095856A3 (en) Urea derivative useful as an anti-cancer agent and process for preparing same
CA2362728A1 (en) Improved aqueous solubility pharmaceutical formulations
RU2002109240A (en) The use of retigabin for neuropathic pain
BR9909796B1 (en) "PIPERIDINOPYRIMIDINE DERIVATIVES FOR TOPICAL APPLICATION"
CA2204745A1 (en) Antiparasitic composition for the treatment and protection of pets
CA2432546A1 (en) Gel for the treatment of cats and dogs
CA2382098A1 (en) Sustained-release, oral pharmaceutical forms of administration
CA2005986A1 (en) Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation
CA2527347A1 (en) Crosslinking systems for hydroxyl polymers
KR970703132A (en) METHOD FOR STABILIZING DUOCARMYCIN DERIVATIVES
CA2255951A1 (en) Substituted 3,5-diphenyl-1,2,4-triazoles and their use as pharmaceutical metal chelators
EP0974576A3 (en) Method of producing benzamide derivatives
EP1065933B1 (en) Antimicrobial solutions
RU98116461A (en) COMPLEX 1- (2-HYDROXYETHYL) -2-METHYL-5-NITROMIDAZOLE WITH POLYVINYL PYRROLIDONE, METHOD FOR PRODUCING, PHARMACEUTICAL COMPOSITION HAVING ANTIMICROBIC ACTION
RU95109157A (en) ANTIHIPPERGLICEMICALLY EFFECTIVE PHARMACEUTICAL COMPOSITION
CA2380757A1 (en) Pharmaceutical agent comprising a benzamide derivative as active ingredient
CA2388244A1 (en) Agents for promoting fattening of animals and method of promoting fattening
CA2005980A1 (en) Benzimidazole derivative with gastric acid inhibitory effect and process for its preparation
WO1999044573B1 (en) Composition and means for treating dry mouth
CA2362833A1 (en) Phenylalaninol derivatives
CA2395209A1 (en) Pack agent in a sheet form
MXPA01007210A (en) Therapeutic agent for parkinson's disease including function improving agent for astrocyte.
CA2393238A1 (en) Aqueous hydraulic medium comprising a formic acid salt
CA2095567A1 (en) Reduced-calorie, low-moisture absorbing bulking agent compositions and methods for preparing same
CA2364446A1 (en) Novel immunosuppressive agent