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RU98113165A - Stable aqueous solution of erythropoietin - Google Patents

Stable aqueous solution of erythropoietin

Info

Publication number
RU98113165A
RU98113165A RU98113165/14A RU98113165A RU98113165A RU 98113165 A RU98113165 A RU 98113165A RU 98113165/14 A RU98113165/14 A RU 98113165/14A RU 98113165 A RU98113165 A RU 98113165A RU 98113165 A RU98113165 A RU 98113165A
Authority
RU
Russia
Prior art keywords
erythropoietin
aqueous solution
stable aqueous
create
per
Prior art date
Application number
RU98113165/14A
Other languages
Russian (ru)
Other versions
RU2128517C1 (en
Original Assignee
Колобков С.Л.
Курочкин С.Н.
Серов С.М.
Filing date
Publication date
Application filed by Колобков С.Л., Курочкин С.Н., Серов С.М. filed Critical Колобков С.Л.
Priority to RU98113165/14A priority Critical patent/RU2128517C1/en
Priority claimed from RU98113165/14A external-priority patent/RU2128517C1/en
Application granted granted Critical
Publication of RU2128517C1 publication Critical patent/RU2128517C1/en
Publication of RU98113165A publication Critical patent/RU98113165A/en

Links

Claims (3)

1. Стабильный водный раствор эритропоэтина, содержащий декстран, отличающийся тем, что он дополнительно содержит цитрат натрия и лимонную кислоту для создания изотонии и pH 6,5-7,5, при концентрации декатрана 6-10 мас.%, его молекулярной массе 30000-60000 и активности эритропоэтина 500-4000 МЕ на 1 мл раствора.1. A stable aqueous solution of erythropoietin containing dextran, characterized in that it additionally contains sodium citrate and citric acid to create isotonia and a pH of 6.5-7.5, with a decatran concentration of 6-10 wt.%, Its molecular weight of 30000- 60,000 and erythropoietin activity of 500-4000 IU per 1 ml of solution. 2. Стабильный водный раствор по п.1, отличающийся тем, что он получен добавлением цитрата натрия и лимонной кислоты к реополиглюкину для создания pH 6,5-7,5 и эритропоэтина в количестве 500-4000 ME на 1 мл с последующим стерилизующим фильтрованием. 2. The stable aqueous solution according to claim 1, characterized in that it is obtained by adding sodium citrate and citric acid to rheopolyglucin to create a pH of 6.5-7.5 and erythropoietin in an amount of 500-4000 ME per 1 ml, followed by sterilizing filtration. 3. Стабильный водный раствор эритропоэтина по п.1, отличающийся тем, что он дополнительно содержит глюкозу или маннит в количестве 5 мас.% 3. A stable aqueous solution of erythropoietin according to claim 1, characterized in that it additionally contains glucose or mannitol in an amount of 5 wt.%
RU98113165/14A 1998-07-20 1998-07-20 Stabilized erythropoietin aqueous solution RU2128517C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU98113165/14A RU2128517C1 (en) 1998-07-20 1998-07-20 Stabilized erythropoietin aqueous solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU98113165/14A RU2128517C1 (en) 1998-07-20 1998-07-20 Stabilized erythropoietin aqueous solution

Publications (2)

Publication Number Publication Date
RU2128517C1 RU2128517C1 (en) 1999-04-10
RU98113165A true RU98113165A (en) 1999-05-20

Family

ID=20208212

Family Applications (1)

Application Number Title Priority Date Filing Date
RU98113165/14A RU2128517C1 (en) 1998-07-20 1998-07-20 Stabilized erythropoietin aqueous solution

Country Status (1)

Country Link
RU (1) RU2128517C1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7078376B1 (en) * 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
RU2192882C1 (en) * 2001-04-18 2002-11-20 Эпштейн Олег Ильич Medicinal agent and method of treatment of pathological syndrome caused by hemopoiesis impairment
RU2335296C1 (en) * 2007-06-26 2008-10-10 Сергей Марович Дудкин Pharmaceutical composition for prevention and treatment of neurologic diseases

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6197229A (en) * 1984-10-18 1986-05-15 Chugai Pharmaceut Co Ltd Stable erythropoietin preparation
US5322837A (en) * 1985-01-11 1994-06-21 Genetics Institute, Inc. Homogeneous erythropoietin compositions and methods of using same
DE3729863A1 (en) * 1987-09-05 1989-03-16 Boehringer Mannheim Gmbh STABILIZED ERYTHROPOIETIN LYOPHILISATES
TW270086B (en) * 1992-10-29 1996-02-11 Kureha Chemical Ind Co Ltd
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin

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