RU97121756A - DIAZOLINE TABLETS RECEIVED ON THE BASIS OF THE SUBSTANCE POWER SUPPLY COMPLEX WITH β-CYCLODEXTRIN OWNED WITH ANTIHISSTAMIN ACTIVITY - Google Patents
DIAZOLINE TABLETS RECEIVED ON THE BASIS OF THE SUBSTANCE POWER SUPPLY COMPLEX WITH β-CYCLODEXTRIN OWNED WITH ANTIHISSTAMIN ACTIVITYInfo
- Publication number
- RU97121756A RU97121756A RU97121756/14A RU97121756A RU97121756A RU 97121756 A RU97121756 A RU 97121756A RU 97121756/14 A RU97121756/14 A RU 97121756/14A RU 97121756 A RU97121756 A RU 97121756A RU 97121756 A RU97121756 A RU 97121756A
- Authority
- RU
- Russia
- Prior art keywords
- cyclodextrin
- antihisstamin
- diazoline
- owned
- activity
- Prior art date
Links
- CJUOSBUQOWKEKJ-UHFFFAOYSA-N Mebhydrolin napadisilate Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O.C1N(C)CCC2=C1C1=CC=CC=C1N2CC1=CC=CC=C1.C1N(C)CCC2=C1C1=CC=CC=C1N2CC1=CC=CC=C1 CJUOSBUQOWKEKJ-UHFFFAOYSA-N 0.000 title claims 4
- 229920000858 Cyclodextrin Polymers 0.000 title claims 3
- 239000001116 FEMA 4028 Substances 0.000 title claims 3
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title claims 3
- 235000011175 beta-cyclodextrine Nutrition 0.000 title claims 3
- 229960004853 betadex Drugs 0.000 title claims 3
- 239000000126 substance Substances 0.000 title claims 3
- 229910002012 Aerosil® Inorganic materials 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 235000021355 Stearic acid Nutrition 0.000 claims 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000008117 stearic acid Substances 0.000 claims 2
- 239000000454 talc Substances 0.000 claims 2
- 229910052623 talc Inorganic materials 0.000 claims 2
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims 1
- 230000001387 anti-histamine Effects 0.000 claims 1
- 239000000739 antihistaminic agent Substances 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 235000012222 talc Nutrition 0.000 claims 1
Claims (1)
Диазолин - 0,046 - 0,054
β-циклодекстрин - 0,13 - 0,15
Кислота стеариновая - 0,0021 - 0,0025
Тальк - 0,0063 - 0,0073
Аэросил - 0,021 - 0,025
Крахмал - 0,0056 - 0,0065Diazolin tablets with antihistamine action, obtained by direct compression, characterized in that tableting is subjected to the product of the interaction of the substance of diazolin with β-cyclodextrin in the presence of auxiliary substances: stearic acid, talc, starch and aerosil in the following ratio per 1 tablet:
Diazolin - 0.046 - 0.054
β-cyclodextrin - 0.13 - 0.15
Stearic acid - 0.0021 - 0.0025
Talc - 0.0063 - 0.0073
Aerosil - 0.021 - 0.025
Starch - 0.0056 - 0.0065
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU97121756A RU2160095C2 (en) | 1997-12-16 | 1997-12-16 | DIAZOLINUM TABLETS PREPARED FROM INCLUSION COMPLEX OF SUBSTANCE WITH β- CYCLODEXTRIN EXHIBITING ANTIHISTAMINE EFFECTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU97121756A RU2160095C2 (en) | 1997-12-16 | 1997-12-16 | DIAZOLINUM TABLETS PREPARED FROM INCLUSION COMPLEX OF SUBSTANCE WITH β- CYCLODEXTRIN EXHIBITING ANTIHISTAMINE EFFECTS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU97121756A true RU97121756A (en) | 1999-08-27 |
| RU2160095C2 RU2160095C2 (en) | 2000-12-10 |
Family
ID=20200575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU97121756A RU2160095C2 (en) | 1997-12-16 | 1997-12-16 | DIAZOLINUM TABLETS PREPARED FROM INCLUSION COMPLEX OF SUBSTANCE WITH β- CYCLODEXTRIN EXHIBITING ANTIHISTAMINE EFFECTS |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2160095C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2264814C2 (en) * | 2003-12-29 | 2005-11-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Antihistamine pharmaceutical composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2045268C1 (en) * | 1987-12-24 | 1995-10-10 | Центр по химии лекарственных средств | Antihistamine and antiallergic agent and method for preparing of glutaminate of hinuclidise-3-diphenylcarbinol as solution for injections |
-
1997
- 1997-12-16 RU RU97121756A patent/RU2160095C2/en active
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