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RU97111783A - NEW LYSINDECARBOXYLASE GENE AND METHOD FOR PRODUCING L-LYSINE - Google Patents

NEW LYSINDECARBOXYLASE GENE AND METHOD FOR PRODUCING L-LYSINE

Info

Publication number
RU97111783A
RU97111783A RU97111783/13A RU97111783A RU97111783A RU 97111783 A RU97111783 A RU 97111783A RU 97111783/13 A RU97111783/13 A RU 97111783/13A RU 97111783 A RU97111783 A RU 97111783A RU 97111783 A RU97111783 A RU 97111783A
Authority
RU
Russia
Prior art keywords
gene
lysine
microorganism
cells
activity
Prior art date
Application number
RU97111783/13A
Other languages
Russian (ru)
Other versions
RU2188235C2 (en
Inventor
Кикути Есими
Сузуки Томоко
Кодзима Хироюки
Original Assignee
Адзиномото Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адзиномото Ко., Инк. filed Critical Адзиномото Ко., Инк.
Publication of RU97111783A publication Critical patent/RU97111783A/en
Application granted granted Critical
Publication of RU2188235C2 publication Critical patent/RU2188235C2/en

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Claims (10)

1. Ген, который кодирует лизиндекарбоксилазу с аминокислотной последовательностью, представленной в SEQ ID NO: 4 в Списке Последовательностей.1. A gene that encodes a lysine decarboxylase with the amino acid sequence shown in SEQ ID NO: 4 in the Sequence Listing. 2. Ген по п. 1, причем ген имеет нуклеотидную последовательность с 1005-го по 3143-й нуклеотид, представленную в SEQ ID NO: 3 в Списке Последовательностей. 2. The gene according to claim 1, wherein the gene has a nucleotide sequence from the 1005th to the 3143rd nucleotide represented in SEQ ID NO: 3 in the Sequence Listing. 3. Ген по п. 1, причем указанная аминокислотная последовательность имеет замену, делекцию или инсерцию одного или множества аминокислотных остатков без какого-либо существенного нарушения активности лизиндекарбоксилазы. 3. The gene according to claim 1, wherein said amino acid sequence has a substitution, deletion or insertion of one or a plurality of amino acid residues without any significant impairment of lysine decarboxylase activity. 4. Микроорганизм, относящийся к роду Escherichia. обладающий способностью продуцировать L-лизин, при снижении или исчезновении в клетках активности лизиндекарбоксилазы. 4. A microorganism belonging to the genus Escherichia. with the ability to produce L-lysine, with a decrease or disappearance in the cells of lysine decarboxylase activity. 5. Микроорганизм по п. 4, причем указанный микроорганизм представляет собой Escherichia coli. 5. The microorganism according to claim 4, wherein said microorganism is Escherichia coli. 6. Микроорганизм по п. 4, в клетках которого активность лизиндекарбоксилазы снижена или исчезает при ограничении экспрессии гена настоящего изобретения по любому из пп. 1-3 и/или гена cadA. 6. The microorganism according to claim 4, in the cells of which the activity of lysine decarboxylase is reduced or disappears while restricting the expression of the gene of the present invention according to any one of claims. 1-3 and / or cadA gene. 7. Микроорганизм по п. 6, в котором экспрессия гена ограничена путем разрушения гена по любому из пп. 1-3 и/или гена cadA. 7. The microorganism according to claim 6, in which the expression of the gene is limited by the destruction of the gene according to any one of paragraphs. 1-3 and / or cadA gene. 8. Микроорганизм по п. 6, в котором ген по любому из пп. 1-3. и/или ген саdА, разрушены/разрушен путем замены, делеции, инсерции, добавки или инверсии одного или множества нуклеотидов в нуклеотидной последовательности или последовательностях. 8. The microorganism according to claim 6, in which the gene according to any one of paragraphs. 1-3. and / or the cadA gene is destroyed / destroyed by substitution, deletion, insertion, addition or inversion of one or a plurality of nucleotides in a nucleotide sequence or sequences. 9. Способ получения L-лизина, включающий в себя стадии культивирования в жидкой среде микроорганизма, относящегося к роду Escherichia, обладающего способностью продуцировать L-лизин, при снижении или исчезновении активности лизиндекарбоксилазы в клетках, что обеспечивает продукцию и накопление L-лизина в культуральной жидкости, и его сбор. 9. A method of producing L-lysine, which includes the stages of culturing in a liquid medium a microorganism belonging to the genus Escherichia, which has the ability to produce L-lysine, with a decrease or disappearance of lysine decarboxylase activity in cells, which ensures the production and accumulation of L-lysine in the culture fluid , and its collection. 10. Способ по п. 9, в котором активность лизиндекарбоксилазы в клетках снижена или исчезает при ограничении экспрессии гена по любому из пп. 1-3 и/или гена саdА. 10. The method according to p. 9, in which the activity of lysine decarboxylase in the cells is reduced or disappears while restricting gene expression according to any one of paragraphs. 1-3 and / or cadA gene.
RU97111783/13A 1994-12-09 1995-12-05 Novel gene of lysine decarboxylase and method of l-lysine producing RU2188235C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP6-306386 1994-12-09
JP30638694 1994-12-09

Publications (2)

Publication Number Publication Date
RU97111783A true RU97111783A (en) 1999-07-20
RU2188235C2 RU2188235C2 (en) 2002-08-27

Family

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RU97111783/13A RU2188235C2 (en) 1994-12-09 1995-12-05 Novel gene of lysine decarboxylase and method of l-lysine producing

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US (1) US5827698A (en)
EP (1) EP0796912B9 (en)
JP (1) JP3692538B2 (en)
KR (1) KR100420743B1 (en)
CN (2) CN100357431C (en)
AU (1) AU703308B2 (en)
BR (1) BR9509896A (en)
CA (1) CA2207271C (en)
CZ (1) CZ290070B6 (en)
DE (1) DE69534801T3 (en)
DK (1) DK0796912T4 (en)
ES (1) ES2256850T5 (en)
HU (1) HU223706B1 (en)
MX (1) MX9704236A (en)
MY (1) MY113738A (en)
PE (1) PE59996A1 (en)
PL (1) PL182903B1 (en)
RU (1) RU2188235C2 (en)
SK (1) SK283478B6 (en)
WO (1) WO1996017930A1 (en)
ZA (1) ZA9510442B (en)

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