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RU96120199A - IMMUNOSUPRESSIVE COMPOSITION CONTAINING CYCLOSPORIN AND METHOD FOR PRODUCING IT - Google Patents

IMMUNOSUPRESSIVE COMPOSITION CONTAINING CYCLOSPORIN AND METHOD FOR PRODUCING IT

Info

Publication number
RU96120199A
RU96120199A RU96120199/14A RU96120199A RU96120199A RU 96120199 A RU96120199 A RU 96120199A RU 96120199/14 A RU96120199/14 A RU 96120199/14A RU 96120199 A RU96120199 A RU 96120199A RU 96120199 A RU96120199 A RU 96120199A
Authority
RU
Russia
Prior art keywords
composition
specified
emulsifier
mixture
composition containing
Prior art date
Application number
RU96120199/14A
Other languages
Russian (ru)
Other versions
RU2119351C1 (en
Inventor
Ким Хьюн-Су
Чой Дзае-Юн
Ли Хье-Веон
Парк Янг-Кеун
Чой Сунг-Вук
Original Assignee
Юхан Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юхан Корпорейшн filed Critical Юхан Корпорейшн
Application granted granted Critical
Publication of RU2119351C1 publication Critical patent/RU2119351C1/en
Publication of RU96120199A publication Critical patent/RU96120199A/en

Links

Claims (11)

1. Композиция, содержащая от 1,0 до 40 вес.% циклоспорина А, от 0,1 до 30 вес. % эмульгатора и от 5 до 80 мас.% пористого декстрина из расчета на общий вес композиции.1. A composition containing from 1.0 to 40 wt.% Cyclosporin A, from 0.1 to 30 weight. % emulsifier and from 5 to 80 wt.% porous dextrin based on the total weight of the composition. 2. Композиция по п.1, в которой указанным эмульгатором является Тилоксапол, Полоксамер или их смесь. 2. The composition according to claim 1, wherein said emulsifier is Tiloxapol, Poloxamer, or a mixture thereof. 3. Способ получения композиции, содержащей циклоспорин А, который включает следующие стадии: растворение циклоспорина А в этаноле с эмульгатором, добавление пористого декстрина для получения смеси и сушка смеси. 3. A method of obtaining a composition containing cyclosporin A, which includes the following stages: dissolving cyclosporin A in ethanol with an emulsifier, adding porous dextrin to obtain a mixture and drying the mixture. 4. Способ по п.3, в котором указанным эмульгатором является Тилоксапол, Полоксамер или их смесь. 4. The method according to claim 3, in which the specified emulsifier is tyloxapol, Poloxamer, or a mixture thereof. 5. Способ по п.3, в котором указанный эмульгатор добавляют в количестве от 0,1 до 30 вес.% из расчета на общий вес композиции. 5. The method according to claim 3, in which the specified emulsifier is added in an amount of from 0.1 to 30 wt.% Based on the total weight of the composition. 6. Способ по п.3, в котором указанный пористый декстрин добавляют в количестве от 5 до 80 вес.% из расчета на общий вес композиции. 6. The method according to claim 3, in which the specified porous dextrin is added in an amount of from 5 to 80 wt.% Based on the total weight of the composition. 7. Способ по п.3, в котором указанный пористый декстрин добавляют в форме его водного раствора. 7. The method according to claim 3, in which the specified porous dextrin is added in the form of its aqueous solution. 8. Способ по п.7, в котором концентрация указанного пористого декстрина в водном растворе составляет от 20 до 50%. 8. The method according to claim 7, in which the concentration of the specified porous dextrin in an aqueous solution is from 20 to 50%. 9. Способ по п.3, в котором указанную сушку осуществляют способом распылительной сушки или сушкой под пониженным давлением. 9. The method according to claim 3, in which the specified drying is carried out by spray drying or drying under reduced pressure. 10. Фармацевтическая рецептура, включающая композицию по п.1 и фармацевтически приемлемый носитель. 10. A pharmaceutical formulation comprising the composition of claim 1 and a pharmaceutically acceptable carrier. 11. Рецептура по п.10, которая представляет собой твердую капсулу. 11. The formulation of claim 10, which is a hard capsule.
RU96120199A 1994-06-01 1995-05-19 Cyclosporin-containing immunosuppressive composition and a method of its preparing RU2119351C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR94-12288 1994-06-01
KR19940012288 1994-06-01

Publications (2)

Publication Number Publication Date
RU2119351C1 RU2119351C1 (en) 1998-09-27
RU96120199A true RU96120199A (en) 1999-01-10

Family

ID=19384450

Family Applications (1)

Application Number Title Priority Date Filing Date
RU96120199A RU2119351C1 (en) 1994-06-01 1995-05-19 Cyclosporin-containing immunosuppressive composition and a method of its preparing

Country Status (13)

Country Link
US (1) US5739105A (en)
EP (1) EP0756489B1 (en)
JP (1) JP2936209B2 (en)
KR (1) KR0163212B1 (en)
CN (1) CN1148224C (en)
AT (1) ATE183398T1 (en)
AU (1) AU2577295A (en)
DE (1) DE69511539T2 (en)
DK (1) DK0756489T3 (en)
ES (1) ES2137516T3 (en)
GR (1) GR3031568T3 (en)
RU (1) RU2119351C1 (en)
WO (1) WO1995032726A1 (en)

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KR100241652B1 (en) * 1997-07-07 2000-03-02 김충섭 Method for preparing a formulation for oral administration of ifuriflavones
EP1023441A1 (en) 1997-10-16 2000-08-02 The Board Of Regents, The University Of Texas System Models and treatments for cardiac hypertrophy in relation with nf-at3 function
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
DE19859910C2 (en) * 1998-12-23 2001-03-22 Ratiopharm Gmbh Oral medicine
ATE404172T1 (en) 1998-12-30 2008-08-15 Dexcel Ltd DISPERSIBLE CONCENTRATE FOR ADMINISTRATION OF CYCLOSPORINE
EP1058539A1 (en) * 1999-01-06 2000-12-13 Korea Research Institute Of Chemical Technology Method of preparing pharmaceutical active ingredient comprising water-insoluble drug and pharmaceutical composition for oral administration comprising the same
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
ATE250924T1 (en) * 2000-04-07 2003-10-15 Medidom Lab EYE MEDICINAL CONTAINING CYCLOSPORINE, HYALURONIC ACID AND POLYSORBATES
GB0008785D0 (en) * 2000-04-10 2000-05-31 Novartis Ag Organic compounds
RU2207870C2 (en) * 2000-11-10 2003-07-10 Панацея Биотек Лимитед Pharmaceutical composition comprising cyclosporine as active component
PT1435910E (en) * 2001-10-19 2009-09-07 Isotechnika Inc Novel cyclosporin analog microemulsion preconcentrates
US6979672B2 (en) * 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
US20050059583A1 (en) 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
SI1802650T1 (en) * 2004-10-01 2012-03-30 Scynexis Inc 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis c infection
EP1655021B1 (en) * 2004-11-09 2008-10-29 Novagali Pharma SA Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential
US7151085B2 (en) 2004-11-15 2006-12-19 Allergan, Inc. Therapeutic methods using cyclosporine components
US7135455B2 (en) * 2004-11-15 2006-11-14 Allergan, Inc Methods for the therapeutic use of cyclosporine components
EP2340789B1 (en) 2005-02-02 2013-05-01 Ossur HF Methods and systems for gathering information regarding a prosthetic foot
GB0921528D0 (en) 2009-12-09 2010-01-27 Mast Carbon Internat Ltd Carbon and its use in blood cleansing applications
JP6200698B2 (en) * 2013-06-18 2017-09-20 ニュートリー株式会社 Swallowing test meal
CN116390762A (en) * 2020-11-09 2023-07-04 思凯制药有限公司 Solid cyclosporin A and dispersion compositions comprising same
WO2022098121A1 (en) * 2020-11-09 2022-05-12 주식회사 스카이테라퓨틱스 Solid material and dispersion composition containing same

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DE2907460A1 (en) * 1978-03-07 1979-09-13 Sandoz Ag NEW RESORBABLE GALENIC COMPOSITIONS
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
JP2577049B2 (en) * 1987-06-04 1997-01-29 三共株式会社 Cyclosporine preparation
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
GB8807505D0 (en) * 1988-03-29 1988-05-05 Glaxo Group Ltd Pharmaceutical combinations
SK277092A3 (en) * 1992-09-07 1996-08-07 Galena As Medicaments with n-methylated cyclic undecapeptides

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