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RU95110938A - Производные 1-(2-оксоацетил)пиперидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения - Google Patents

Производные 1-(2-оксоацетил)пиперидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения

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Publication number
RU95110938A
RU95110938A RU95110938/04A RU95110938A RU95110938A RU 95110938 A RU95110938 A RU 95110938A RU 95110938/04 A RU95110938/04 A RU 95110938/04A RU 95110938 A RU95110938 A RU 95110938A RU 95110938 A RU95110938 A RU 95110938A
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RU
Russia
Prior art keywords
treatment
many drugs
compounds
pyperidine
oxoacetyl
Prior art date
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RU95110938/04A
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English (en)
Other versions
RU2158258C2 (ru
Inventor
М.Армистид Дэвид
Us]
О.Саундерс Джеффри
С.Богер Джошуа
Original Assignee
Вертекс Фармасьютикалз Инкорпорейтед (Us)
Вертекс Фармасьютикалз Инкорпорейтед
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Publication of RU95110938A publication Critical patent/RU95110938A/ru
Application granted granted Critical
Publication of RU2158258C2 publication Critical patent/RU2158258C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Изобретение относится к новым соединениям формулы I, которые поддерживают, повышают или восстанавливают чувствительность клеток к терапевтическим или профилактическим средствам. Изобретение относится также к фармацевтическим композициям, содержащим эти соединения. Эти соединения и фармацевтические композиции, в частности, хорошо пригодны для лечения клеток, устойчивых к действию многих лекарственных средств, для предотвращения развития устойчивости ко многим лекарственным средствам и для терапии ракового заболевания, устойчивого ко многим лекарственным средствам.

Claims (1)

  1. Изобретение относится к новым соединениям формулы I, которые поддерживают, повышают или восстанавливают чувствительность клеток к терапевтическим или профилактическим средствам. Изобретение относится также к фармацевтическим композициям, содержащим эти соединения. Эти соединения и фармацевтические композиции, в частности, хорошо пригодны для лечения клеток, устойчивых к действию многих лекарственных средств, для предотвращения развития устойчивости ко многим лекарственным средствам и для терапии ракового заболевания, устойчивого ко многим лекарственным средствам.
RU95110938/04A 1992-09-28 1993-09-27 Производные 1-(2-оксоацетил)пиперидин- или пирролидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения RU2158258C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US95229992A 1992-09-28 1992-09-28
US07/952,299 1992-09-28
US07/952299 1992-09-28

Publications (2)

Publication Number Publication Date
RU95110938A true RU95110938A (ru) 1997-01-10
RU2158258C2 RU2158258C2 (ru) 2000-10-27

Family

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RU95110938/04A RU2158258C2 (ru) 1992-09-28 1993-09-27 Производные 1-(2-оксоацетил)пиперидин- или пирролидин-2-карбоновых кислот, фармацевтическая композиция, способ лечения, способ получения

Country Status (29)

Country Link
EP (1) EP0662958B1 (ru)
JP (1) JP3635493B2 (ru)
KR (1) KR100300112B1 (ru)
CN (2) CN1494906A (ru)
AT (1) ATE229506T1 (ru)
AU (1) AU690082B2 (ru)
BG (1) BG62729B1 (ru)
CA (1) CA2144962C (ru)
CZ (1) CZ287396B6 (ru)
DE (1) DE69332563T2 (ru)
DK (1) DK0662958T3 (ru)
ES (1) ES2188595T3 (ru)
FI (1) FI951454A7 (ru)
HU (1) HUT72046A (ru)
IL (1) IL107109A (ru)
IS (1) IS4073A (ru)
MX (1) MX9305934A (ru)
MY (1) MY119483A (ru)
NO (1) NO305596B1 (ru)
NZ (2) NZ314207A (ru)
PL (1) PL308217A1 (ru)
PT (1) PT662958E (ru)
RO (1) RO117791B1 (ru)
RU (1) RU2158258C2 (ru)
SG (1) SG47517A1 (ru)
SK (1) SK284129B6 (ru)
TW (1) TW304943B (ru)
UA (1) UA63874C2 (ru)
WO (1) WO1994007858A1 (ru)

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Also Published As

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DE69332563D1 (de) 2003-01-23
CN1088577A (zh) 1994-06-29
RU2158258C2 (ru) 2000-10-27
CZ287396B6 (en) 2000-11-15
NO305596B1 (no) 1999-06-28
CN1086386C (zh) 2002-06-19
CN1494906A (zh) 2004-05-12
SG47517A1 (en) 1998-04-17
NZ256772A (en) 1997-03-24
KR100300112B1 (ko) 2001-10-22
AU690082B2 (en) 1998-04-23
PL308217A1 (en) 1995-07-24
ES2188595T3 (es) 2003-07-01
CA2144962C (en) 2003-05-20
AU5164893A (en) 1994-04-26
FI951454A0 (fi) 1995-03-27
MX9305934A (es) 1994-03-31
DE69332563T2 (de) 2003-11-27
HUT72046A (en) 1996-03-28
ATE229506T1 (de) 2002-12-15
NO951162L (no) 1995-05-29
EP0662958A1 (en) 1995-07-19
CZ76995A3 (en) 1995-12-13
NZ314207A (en) 2000-12-22
IS4073A (is) 1994-03-29
JP3635493B2 (ja) 2005-04-06
RO117791B1 (ro) 2002-07-30
EP0662958B1 (en) 2002-12-11
BG62729B1 (bg) 2000-06-30
NO951162D0 (no) 1995-03-27
FI951454L (fi) 1995-03-27
IL107109A0 (en) 1993-12-28
JPH08502256A (ja) 1996-03-12
CA2144962A1 (en) 1994-04-14
TW304943B (ru) 1997-05-11
SK284129B6 (sk) 2004-09-08
PT662958E (pt) 2003-04-30
FI951454A7 (fi) 1995-03-27
HK1013992A1 (en) 1999-09-17
IL107109A (en) 1999-03-12
MY119483A (en) 2005-06-30
DK0662958T3 (da) 2003-03-31
BG99585A (bg) 1995-12-29
WO1994007858A1 (en) 1994-04-14
SK38995A3 (en) 1995-08-09
UA63874C2 (en) 2004-02-16

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