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RU95106651A - Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states - Google Patents

Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states

Info

Publication number
RU95106651A
RU95106651A RU95106651/14A RU95106651A RU95106651A RU 95106651 A RU95106651 A RU 95106651A RU 95106651/14 A RU95106651/14 A RU 95106651/14A RU 95106651 A RU95106651 A RU 95106651A RU 95106651 A RU95106651 A RU 95106651A
Authority
RU
Russia
Prior art keywords
tyr
des
analogs
dinorphin
dinorphine
Prior art date
Application number
RU95106651/14A
Other languages
Russian (ru)
Inventor
М.Ли Нэнси
Us]
Х.Лох Хорак
Е.Такемори Акира
Original Assignee
Де-Тюр Дайнорфин Партнершип (US)
Де-Тюр Дайнорфин Партнершип
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Де-Тюр Дайнорфин Партнершип (US), Де-Тюр Дайнорфин Партнершип filed Critical Де-Тюр Дайнорфин Партнершип (US)
Publication of RU95106651A publication Critical patent/RU95106651A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Новые пептиды изобретения являются аналогами динорфина и характеризуются активностью, аналогичной активности эндогенного динорфина, хотя и являются дез-Тyr - или дез-Тyr -Gly- аналогами эндогенного динорфина. Новые пептиды находят применение в медицине, например, введением хозяину с толерантностью к наркотическому анальгетику с целью усиления действия наркотического анальгетика и/или блокирования симптомов абстиненции.The new peptides of the invention are analogs of dinorphin and are characterized by activity similar to the activity of endogenous dinorphin, although they are des-Tyr - or des-Tyr -Gly - analogues of endogenous dinorphin. New peptides are used in medicine, for example, by administering to a host with a tolerance to narcotic analgesics in order to enhance the effects of narcotic analgesics and / or block withdrawal symptoms.

Claims (1)

Новые пептиды изобретения являются аналогами динорфина и характеризуются активностью, аналогичной активности эндогенного динорфина, хотя и являются дез-Тyr - или дез-Тyr -Gly- аналогами эндогенного динорфина. Новые пептиды находят применение в медицине, например, введением хозяину с толерантностью к наркотическому анальгетику с целью усиления действия наркотического анальгетика и/или блокирования симптомов абстиненции.The new peptides of the invention are analogs of dinorphin and are characterized by activity similar to the activity of endogenous dinorphin, although they are des-Tyr - or des-Tyr -Gly - analogues of endogenous dinorphin. New peptides are used in medicine, for example, by administering to a host with a tolerance to narcotic analgesics in order to enhance the effects of narcotic analgesics and / or block withdrawal symptoms.
RU95106651/14A 1992-06-12 1993-06-01 Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states RU95106651A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89792092A 1992-06-12 1992-06-12
US07/897,920 1992-06-12

Publications (1)

Publication Number Publication Date
RU95106651A true RU95106651A (en) 1996-12-27

Family

ID=25408662

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95106651/14A RU95106651A (en) 1992-06-12 1993-06-01 Analogs of des-tyr-dinorphine and method of treatment of patient with tolerant states

Country Status (11)

Country Link
EP (1) EP0652765A4 (en)
JP (1) JPH08501075A (en)
KR (1) KR950701818A (en)
AU (1) AU4399093A (en)
CA (1) CA2137916A1 (en)
CZ (1) CZ281630B6 (en)
FI (1) FI945811L (en)
HU (1) HUT70160A (en)
NO (1) NO944778L (en)
RU (1) RU95106651A (en)
WO (1) WO1993025217A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5482930A (en) * 1993-06-09 1996-01-09 The Regents Of The University Of California Anti-inflammatory composition and method with des-Tyr dynorphin and analogues
EP1009407B1 (en) 1997-09-04 2004-04-28 Novoneuron, Inc. Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
US6437092B1 (en) 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
EP2100901A1 (en) 1999-05-17 2009-09-16 ConjuChem Biotechnologies Inc. Modified Insulin and conjugates thereof
US7601691B2 (en) 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6706892B1 (en) 1999-09-07 2004-03-16 Conjuchem, Inc. Pulmonary delivery for bioconjugation
CN101696240A (en) 2001-02-02 2010-04-21 康久化学生物技术公司 Long lasting growth hormone releasing factor derivatives
WO2002066511A2 (en) 2001-02-16 2002-08-29 Conjuchem Inc. Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
UA111065C2 (en) 2010-07-23 2016-03-25 Демеркс, Інк. Noribogaine compositions
EP2481740B1 (en) 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
JP2015500833A (en) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド Nolibogaine phosphate
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
EP2934541A4 (en) 2012-12-20 2016-08-03 Demerx Inc Substituted noribogaine
US10428115B2 (en) 2013-05-24 2019-10-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Dynorphin A analogs with bradykinin receptors specificity for modulation of neuropathic pain
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0788371A1 (en) * 1994-08-26 1997-08-13 LEE, Nancy M. Analgesic method with dynorphin analogues truncated at the n-terminus

Also Published As

Publication number Publication date
HU9403563D0 (en) 1995-02-28
CA2137916A1 (en) 1993-12-23
FI945811A7 (en) 1995-02-06
EP0652765A4 (en) 1997-04-09
JPH08501075A (en) 1996-02-06
NO944778L (en) 1995-02-10
AU4399093A (en) 1994-01-04
HUT70160A (en) 1995-09-28
FI945811L (en) 1995-02-06
CZ281630B6 (en) 1996-11-13
FI945811A0 (en) 1994-12-09
NO944778D0 (en) 1994-12-09
EP0652765A1 (en) 1995-05-17
KR950701818A (en) 1995-05-17
CZ313194A3 (en) 1995-08-16
WO1993025217A1 (en) 1993-12-23

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