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RU94042240A - Антагонисты рецепторов возбужденных аминокислот, способ получения, промежуточные соединения, фармацевтическая композиция - Google Patents

Антагонисты рецепторов возбужденных аминокислот, способ получения, промежуточные соединения, фармацевтическая композиция

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Publication number
RU94042240A
RU94042240A RU94042240/04A RU94042240A RU94042240A RU 94042240 A RU94042240 A RU 94042240A RU 94042240/04 A RU94042240/04 A RU 94042240/04A RU 94042240 A RU94042240 A RU 94042240A RU 94042240 A RU94042240 A RU 94042240A
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RU
Russia
Prior art keywords
amino acid
receptor antagonists
acid receptor
pharmaceutical composition
preparation process
Prior art date
Application number
RU94042240/04A
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English (en)
Inventor
Джозеф Хейнц Лоуренс
Us]
Генри Уолкер Ланн Уильям
Дарвин Шопп Даррил
Original Assignee
Эли Лилли энд Компани (US)
Эли Лилли Энд Компани
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Publication of RU94042240A publication Critical patent/RU94042240A/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
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    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Изобретение относится к новым соединениям, которые воздействуют на рецепторы возбужденных аминокислот и используются в лечении неврологических заболеваний, а также к синтетическим методам получения указанных новых соединений.

Claims (1)

  1. Изобретение относится к новым соединениям, которые воздействуют на рецепторы возбужденных аминокислот и используются в лечении неврологических заболеваний, а также к синтетическим методам получения указанных новых соединений.
RU94042240/04A 1993-12-03 1994-11-30 Антагонисты рецепторов возбужденных аминокислот, способ получения, промежуточные соединения, фармацевтическая композиция RU94042240A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16183093A 1993-12-03 1993-12-03
US08/161830 1993-12-03
US08/322632 1994-10-13
US08/322,632 US5576323A (en) 1993-12-03 1994-10-13 Excitatory amino acid receptor antagonists

Publications (1)

Publication Number Publication Date
RU94042240A true RU94042240A (ru) 1996-10-10

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RU94042240/04A RU94042240A (ru) 1993-12-03 1994-11-30 Антагонисты рецепторов возбужденных аминокислот, способ получения, промежуточные соединения, фармацевтическая композиция

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US (2) US5576323A (ru)
EP (1) EP0658539A1 (ru)
JP (1) JPH07267908A (ru)
KR (1) KR950018015A (ru)
CN (1) CN1108240A (ru)
AU (1) AU676781B2 (ru)
BR (1) BR9404809A (ru)
CA (1) CA2136904A1 (ru)
CO (1) CO4290421A1 (ru)
CZ (1) CZ294794A3 (ru)
FI (1) FI945704A7 (ru)
HU (1) HUT69181A (ru)
IL (1) IL111789A0 (ru)
NO (1) NO944578L (ru)
NZ (1) NZ270009A (ru)
PE (1) PE42595A1 (ru)
PL (1) PL306038A1 (ru)
RU (1) RU94042240A (ru)
TW (1) TW287157B (ru)
YU (1) YU70394A (ru)
ZA (1) ZA949405B (ru)

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US20040138104A1 (en) * 2003-01-14 2004-07-15 The Government Of The United States Of America Represented By The Secretary, Peptides
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JO2978B1 (en) * 2009-12-21 2016-03-15 ايلي ليلي اند كومباني MGLU2 aids
ES2587204T3 (es) 2011-06-17 2016-10-21 Eli Lilly And Company Derivados de ácido biciclo (3.1.0) hexano-2,6-dicarboxílico como agonistas del receptor mGlu2
CN102633657B (zh) * 2012-03-30 2014-05-14 甘肃科瑞生物科技有限公司 一种顺式3-氨基-环戊醇盐酸盐的制备方法
CN104193612B (zh) * 2014-08-12 2016-03-02 深圳市道尔顿电子材料有限公司 一种2,3,5-三羧基环戊基乙酸的制备方法
CN107936040B (zh) * 2017-12-08 2019-04-09 珠海联邦制药股份有限公司 一种替格瑞洛中间体的合成工艺

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HUT69181A (en) 1995-08-28
KR950018015A (ko) 1995-07-22
CA2136904A1 (en) 1995-06-04
FI945704A0 (fi) 1994-12-02
HU9403469D0 (en) 1995-02-28
YU70394A (sh) 1997-12-05
NO944578L (no) 1995-06-06
CN1108240A (zh) 1995-09-13
TW287157B (ru) 1996-10-01
AU7915194A (en) 1995-06-08
CO4290421A1 (es) 1996-04-17
JPH07267908A (ja) 1995-10-17
ZA949405B (en) 1996-05-28
NZ270009A (en) 1997-01-29
PE42595A1 (es) 1995-12-12
CZ294794A3 (en) 1995-12-13
IL111789A0 (en) 1995-01-24
BR9404809A (pt) 1995-08-01
US5576323A (en) 1996-11-19
AU676781B2 (en) 1997-03-20
NO944578D0 (no) 1994-11-29
EP0658539A1 (en) 1995-06-21
US5843997A (en) 1998-12-01
PL306038A1 (en) 1995-06-12
FI945704A7 (fi) 1995-06-04

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