RU94030471A - Compounds, method of synthesis, pharmaceutical composition, method of rheumatic arthritis treatment - Google Patents
Compounds, method of synthesis, pharmaceutical composition, method of rheumatic arthritis treatmentInfo
- Publication number
- RU94030471A RU94030471A RU94030471/04A RU94030471A RU94030471A RU 94030471 A RU94030471 A RU 94030471A RU 94030471/04 A RU94030471/04 A RU 94030471/04A RU 94030471 A RU94030471 A RU 94030471A RU 94030471 A RU94030471 A RU 94030471A
- Authority
- RU
- Russia
- Prior art keywords
- group
- alkyl
- hydrogen atom
- alkoxy
- substituent
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
FIELD: organic chemistry. SUBSTANCE: product: compounds of the formulaand their pharmaceutically acceptable salts where R- hydrogen atom, alkyl, hydroxyl, carboxyalkylene, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogen-containing alkyl, carboxyl, alkoxycarbonyl or alkanoylamino-group; R- hydrogen atom, halogen atom, alkoxy-, hydroxy-, alkanoyloxy- or phenoxy-group; R- hydrogen atom or alkyl group; R- hydrogen atom, halogen atom, alkoxycarbonyl, benzylcarbonyl, alkanoyl, benzoyl, carbamoyl, alkyl, carboxyl, hydroxyalkyl or alkylthio-group; R- hydrogen atom or alkyl group; R- hydrogen atom, alkyl group (possibly substituted with one or more substituents taken from hydroxy-group, halogen atom or amino-group of the formula NRR), alicyclic hydrocarbon, phenyl, (cycloalkyl)alkyl or benzyl group; R- hydrogen atom, halogen atom, trifluoromethyl, trifluoromethoxy, alkyl, carboxyl or alkoxy-group; R- hydrogen atom, halogen atom, trifluoromethyl, trifluoromethoxy, alkyl or alkoxy-group; R- hydrogen atom or alkyl group. Synthesized compounds are antirheumatic agents. Also, compositions containing these compounds and methods of their synthesis were given. EFFECT: improved method of synthesis.
Claims (1)
где заместитель R1 представляет собой атом водорода, алкильную, гидроксильную группу, карбоксиалкиленовую группу, алкоксикарбонилалкенильную группу, гидроксиалкильную группу, карбоксиалкильную группу, алкоксикарбонилалкильную группу, алкокси-группу, галогенсодержащую алкильную группу, карбоксильную группу, алкоксикарбонильную группу или алканоиламино-группу; заместитель R2 представляет собой атом водорода, атом галогена, алкокси-, гидрокси-, алканоилокси- или фенокси-группу; заместитель R3 представляет собой атом водорода или алкильную группу; заместитель R4 представляет собой атом водорода, атом галогена, алкоксикарбонильную, бензилокарбонильную, алканоильную, бензоильную, карбамоильную, алкильную, карбоксильную, гидроксиалкильную или алкилтио-группу; заместитель R5 представляет собой атом водорода или алкильную группу; заместитель R6 представляет собой атом водорода, алкильную группу (возможно замещенную одним или более заместителями из числа гидрокси-группы, атома галогена или аминогруппы формулы -NR12R13), алициклическую углеводородную группу, фенильную группу, (циклоалкил)алкильную или бензильную группу; заместитель R7 представляет собой атом водорода, атом галогена, трифторметильную, трифторметокси-, алкильную группу, карбоксильную или алкокси-группу; заместитель R8 представляет собой атом водорода, атом галогена, трифторметильную, трифторметокси-, алкильную или алкокси-группу; заместитель R9 представляет собой атом водорода или алкильную группу, которые являются противоревматическими агентами. Также раскрываются композиции, содержащие эти соединения и способы их получения.The invention relates to compounds of this formula and their pharmaceutically acceptable salts
where the substituent R 1 represents a hydrogen atom, an alkyl, hydroxyl group, a carboxyalkylene group, an alkoxycarbonylalkenyl group, a hydroxyalkyl group, a carboxyalkyl group, an alkoxycarbonylalkyl group, an alkoxy group, a halogen-containing alkyl group, a carboxyl group, an alkoxycarbonyl group or an alkanoyl group; R 2 represents a hydrogen atom, a halogen atom, an alkoxy, hydroxy, alkanoyloxy or phenoxy group; the substituent R 3 represents a hydrogen atom or an alkyl group; the substituent R 4 represents a hydrogen atom, a halogen atom, an alkoxycarbonyl, benzyl carbonyl, alkanoyl, benzoyl, carbamoyl, alkyl, carboxyl, hydroxyalkyl or alkylthio group; the substituent R 5 represents a hydrogen atom or an alkyl group; the substituent R 6 represents a hydrogen atom, an alkyl group (possibly substituted by one or more substituents from a hydroxy group, a halogen atom or an amino group of the formula —NR 12 R 13 ), an alicyclic hydrocarbon group, a phenyl group, a (cycloalkyl) alkyl or benzyl group; the substituent R 7 represents a hydrogen atom, a halogen atom, a trifluoromethyl, trifluoromethoxy, alkyl group, a carboxyl or alkoxy group; R 8 represents a hydrogen atom, a halogen atom, a trifluoromethyl, trifluoromethoxy, alkyl or alkoxy group; the substituent R 9 represents a hydrogen atom or an alkyl group which are antirheumatic agents. Compositions containing these compounds and methods for their preparation are also disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9127252.6 | 1991-12-23 | ||
| GB919127252A GB9127252D0 (en) | 1991-12-23 | 1991-12-23 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU94030471A true RU94030471A (en) | 1996-04-20 |
Family
ID=10706032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94030471/04A RU94030471A (en) | 1991-12-23 | 1992-12-12 | Compounds, method of synthesis, pharmaceutical composition, method of rheumatic arthritis treatment |
Country Status (3)
| Country | Link |
|---|---|
| RU (1) | RU94030471A (en) |
| YU (1) | YU110792A (en) |
| ZA (1) | ZA929916B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2617700C2 (en) * | 2011-08-12 | 2017-04-26 | Синомикс, Инк. | 4-aminoquinoline-3-carboxylic acid derivatives and compositions containing them for enhancing sweet taste |
-
1992
- 1992-12-12 RU RU94030471/04A patent/RU94030471A/en unknown
- 1992-12-21 ZA ZA929916A patent/ZA929916B/en unknown
- 1992-12-23 YU YU110792A patent/YU110792A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2617700C2 (en) * | 2011-08-12 | 2017-04-26 | Синомикс, Инк. | 4-aminoquinoline-3-carboxylic acid derivatives and compositions containing them for enhancing sweet taste |
Also Published As
| Publication number | Publication date |
|---|---|
| YU110792A (en) | 1996-01-08 |
| ZA929916B (en) | 1993-06-23 |
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