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RU94026094A - Применение феналкиламинов - Google Patents

Применение феналкиламинов

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Publication number
RU94026094A
RU94026094A RU94026094/14A RU94026094A RU94026094A RU 94026094 A RU94026094 A RU 94026094A RU 94026094/14 A RU94026094/14 A RU 94026094/14A RU 94026094 A RU94026094 A RU 94026094A RU 94026094 A RU94026094 A RU 94026094A
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Russia
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alkyl
halogen
formula
atom
group
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RU94026094/14A
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English (en)
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RU2141942C1 (ru
Inventor
Аэби Йоханнес
Ch]
Герри Филипп
Джолидон Синес
Моран Оливиер
Fr]
Original Assignee
Ф.Хоффманн-Ля Рош Аг (Ch)
Ф.Хоффманн-Ля Рош Аг
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Publication of RU94026094A publication Critical patent/RU94026094A/ru
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Publication of RU2141942C1 publication Critical patent/RU2141942C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/22—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Применение соединений формулы Iгде один из R<M^>1<D> и R<M^>2<D> представляет собой С<Mv>1-7<D> алкил, а другой представляет собой С<Mv>1-7<D>-алкил либо С<Mv>2-6<D>-алкенилметил, L представляет собой при определенных условиях связанный через О-атом с фенильной группой С<Mv>1-11<D>-алкилен либо С<Mv>2-11<D>-алкенилен, или L представляет собой 1,4-фенилен, n обозначает 0 либо, если L содержит O-атом, n обозначает 0 или 1, Q представляет собой С<Mv>1-7<D>-алкил, C<Mv>2-10<D>-алкенил либо группу формулы Q':R представляет собой Н, галоген, СF<Mv>3<D>, CN либо NO<Mv>2<D>, R<M^ >3<D> и R<M^ >4<D> представляют собой Н, С<Mv>1-4<D>-алкил либо галоген и R<M^ >5<D> представляет собой Н либо, если R - водород, Н или галоген, и их приемлемых в фармацевтике аддитивных солей кислот для изготовления лекарственных средств, снижающих содержание холестерина, а также новые соединения, соответствующие формуле I.

Claims (1)

  1. Применение соединений формулы I
    Figure 00000001

    где один из R<M^>1<D> и R<M^>2<D> представляет собой С<Mv>1-7<D> алкил, а другой представляет собой С<Mv>1-7<D>-алкил либо С<Mv>2-6<D>-алкенилметил, L представляет собой при определенных условиях связанный через О-атом с фенильной группой С<Mv>1-11<D>-алкилен либо С<Mv>2-11<D>-алкенилен, или L представляет собой 1,4-фенилен, n обозначает 0 либо, если L содержит O-атом, n обозначает 0 или 1, Q представляет собой С<Mv>1-7<D>-алкил, C<Mv>2-10<D>-алкенил либо группу формулы Q':
    Figure 00000002

    R представляет собой Н, галоген, СF<Mv>3<D>, CN либо NO<Mv>2<D>, R<M^ >3<D> и R<M^ >4<D> представляют собой Н, С<Mv>1-4<D>-алкил либо галоген и R<M^ >5<D> представляет собой Н либо, если R - водород, Н или галоген, и их приемлемых в фармацевтике аддитивных солей кислот для изготовления лекарственных средств, снижающих содержание холестерина, а также новые соединения, соответствующие формуле I.
RU94026094/04A 1993-07-14 1994-07-08 Алкиламинокетоны RU2141942C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH2107/93 1993-07-14
CH210793 1993-07-14
CH1320/94 1994-04-28
CH132094 1994-04-28

Publications (2)

Publication Number Publication Date
RU94026094A true RU94026094A (ru) 1996-05-20
RU2141942C1 RU2141942C1 (ru) 1999-11-27

Family

ID=25687322

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94026094/04A RU2141942C1 (ru) 1993-07-14 1994-07-08 Алкиламинокетоны

Country Status (22)

Country Link
US (3) US5495048A (ru)
EP (1) EP0636367B1 (ru)
JP (1) JP2519022B2 (ru)
KR (1) KR100312441B1 (ru)
CN (1) CN1087934C (ru)
AT (1) ATE191142T1 (ru)
AU (1) AU684507B2 (ru)
CA (1) CA2126518C (ru)
CZ (1) CZ288518B6 (ru)
DE (1) DE59409248D1 (ru)
DK (1) DK0636367T3 (ru)
ES (1) ES2144471T3 (ru)
GR (1) GR3033645T3 (ru)
HU (1) HUT70835A (ru)
IL (1) IL110254A (ru)
NO (1) NO309924B1 (ru)
NZ (1) NZ260968A (ru)
PH (1) PH31092A (ru)
PT (1) PT636367E (ru)
RU (1) RU2141942C1 (ru)
TW (1) TW438774B (ru)
UA (1) UA37199C2 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
CA2190699A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
AU8964201A (en) 2000-07-18 2002-01-30 Hoffmann La Roche Novel aniline derivatives
RU2225393C1 (ru) 2000-08-16 2004-03-10 Ф.Хоффманн-Ля Рош Аг Новые производные аминоциклогексана
US6964974B2 (en) 2000-09-08 2005-11-15 Hoffmann-La Roche Inc. 2,3-oxidosqualene-lanosterol cyclase inhibitors
US6503907B2 (en) * 2000-11-28 2003-01-07 Hoffmann-La Roche Inc. Indole and dihydroindole derivatives
US6706751B2 (en) 2000-12-21 2004-03-16 Hoffman-La Roche Inc. Dihydroindole and tetrahydroquinoline derivatives
PL371471A1 (en) * 2001-12-12 2005-06-13 F.Hoffmann-La Roche Ag Substituted cyclohexane derivatives
US7012077B2 (en) * 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives
US6727277B1 (en) 2002-11-12 2004-04-27 Kansas State University Research Foundation Compounds affecting cholesterol absorption
TW200524849A (en) * 2003-07-02 2005-08-01 Hoffmann La Roche Hydroxyalkylamide derivatives
MXPA06003030A (es) * 2003-09-22 2006-06-23 Hoffmann La Roche Derivados de ciclohexilo sustituidos con aminoalquilamida.
CN101583593A (zh) * 2006-11-13 2009-11-18 辉瑞产品公司 二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
CN108530390B (zh) * 2017-03-06 2020-04-21 西南化工研究设计院有限公司 一种4-羟基二苯甲酮的烷基化方法

Family Cites Families (7)

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US3647863A (en) * 1968-11-25 1972-03-07 Richardson Merrell Inc Aminoalkoxy-triphenyl ethylenes and the salts thereof
US3928449A (en) * 1969-04-03 1975-12-23 Sandoz Ag Aminoalkoxy-terphenyls and the salts thereof
CA2016738A1 (en) * 1989-06-08 1990-12-08 Philippe Guerry Substituted aminoalkylbenzene derivatives
CA2020888A1 (en) * 1989-07-27 1991-01-28 Philippe Guerry Substituted aminoalkoxybenzene derivatives
US5214046A (en) * 1989-07-27 1993-05-25 Hoffmann-La Roche Inc. Substituted aminoalkoxybenzene anti-fungicidal compositions and use
CA2044533A1 (en) * 1990-06-29 1991-12-30 Philippe Guerry Substituted aminoalkylbiphenyl derivatives
US5239084A (en) * 1990-06-29 1993-08-24 Hoffmann-La Roche Inc. Substituted aminoalkyl biphenyl compounds

Also Published As

Publication number Publication date
PT636367E (pt) 2000-07-31
NO942606L (no) 1995-01-16
JPH0753479A (ja) 1995-02-28
KR960014096A (ko) 1996-05-22
DK0636367T3 (da) 2000-07-31
CZ167694A3 (en) 1995-01-18
IL110254A0 (en) 1994-10-21
NO309924B1 (no) 2001-04-23
US5574071A (en) 1996-11-12
NO942606D0 (no) 1994-07-12
TW438774B (en) 2001-06-07
EP0636367A1 (de) 1995-02-01
CZ288518B6 (cs) 2001-07-11
RU2141942C1 (ru) 1999-11-27
CA2126518A1 (en) 1995-01-15
DE59409248D1 (de) 2000-05-04
AU684507B2 (en) 1997-12-18
GR3033645T3 (en) 2000-10-31
HUT70835A (en) 1995-11-28
PH31092A (en) 1998-02-05
CA2126518C (en) 2006-11-21
CN1087934C (zh) 2002-07-24
AU6735894A (en) 1995-01-27
UA37199C2 (ru) 2001-05-15
KR100312441B1 (ko) 2002-10-31
US5495048A (en) 1996-02-27
CN1103781A (zh) 1995-06-21
ATE191142T1 (de) 2000-04-15
HU9402085D0 (en) 1994-09-28
ES2144471T3 (es) 2000-06-16
US5637771A (en) 1997-06-10
EP0636367B1 (de) 2000-03-29
IL110254A (en) 1998-04-05
JP2519022B2 (ja) 1996-07-31
NZ260968A (en) 1996-06-25

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