RU94016389A - CARBAMATS AND CARBAMIDES INDUCING CYTOKINE PRODUCTION - Google Patents
CARBAMATS AND CARBAMIDES INDUCING CYTOKINE PRODUCTIONInfo
- Publication number
- RU94016389A RU94016389A RU94016389/04A RU94016389A RU94016389A RU 94016389 A RU94016389 A RU 94016389A RU 94016389/04 A RU94016389/04 A RU 94016389/04A RU 94016389 A RU94016389 A RU 94016389A RU 94016389 A RU94016389 A RU 94016389A
- Authority
- RU
- Russia
- Prior art keywords
- carbamides
- cytokine production
- carbamats
- inducing cytokine
- compounds
- Prior art date
Links
- 230000016396 cytokine production Effects 0.000 title claims 2
- 150000003672 ureas Chemical class 0.000 title claims 2
- 230000001939 inductive effect Effects 0.000 title 1
- 208000035473 Communicable disease Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000032467 Aplastic anaemia Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 claims 1
- 235000013877 carbamide Nutrition 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
Claims (1)
которые стимулируют продуцирование цитокинов и могут быть использованы для ускорения выздоровления при нейтропении, сопровождающей радио- и химиотерапию, трансплантацию костного мозга или инфекционные заболевания. Соединения изобретения или фармацевтические композиции, применяющие эти соединения, могут быть полезны при лечении злокачественных опухолей, СПИДа, апластической анемии, миелодиспластического синдрома, инфекционных заболеваний и для усиления имунной реакции.The invention relates to new carbamides and carbamates:
which stimulate cytokine production and can be used to accelerate recovery from neutropenia accompanying radio and chemotherapy, bone marrow transplantation or infectious diseases. The compounds of the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of malignant tumors, AIDS, aplastic anemia, myelodysplastic syndrome, infectious diseases and to enhance the immune response.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/063.174 | 1993-05-12 | ||
| US08/063,174 US5312831A (en) | 1993-05-12 | 1993-05-12 | Urethanes and ureas that induce cytokine production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94016389A true RU94016389A (en) | 1996-01-10 |
| RU2135515C1 RU2135515C1 (en) | 1999-08-27 |
Family
ID=22047440
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94016389A RU2135515C1 (en) | 1993-05-12 | 1994-05-11 | Cytokines production-inducing carbamates and ureas |
Country Status (26)
| Country | Link |
|---|---|
| US (6) | US5312831A (en) |
| EP (1) | EP0652228B1 (en) |
| JP (1) | JP3583469B2 (en) |
| KR (1) | KR100296543B1 (en) |
| CN (1) | CN1094943C (en) |
| AT (1) | ATE144533T1 (en) |
| AU (1) | AU669064B2 (en) |
| CA (1) | CA2123261A1 (en) |
| CZ (1) | CZ290445B6 (en) |
| DE (1) | DE69400798T2 (en) |
| DK (1) | DK0652228T3 (en) |
| ES (1) | ES2094004T3 (en) |
| FI (1) | FI942186A7 (en) |
| GR (1) | GR3022253T3 (en) |
| HU (1) | HU219768B (en) |
| IL (1) | IL109602A (en) |
| NO (1) | NO311223B1 (en) |
| NZ (1) | NZ260507A (en) |
| PH (1) | PH30182A (en) |
| PL (1) | PL179984B1 (en) |
| RU (1) | RU2135515C1 (en) |
| SG (1) | SG43071A1 (en) |
| SI (1) | SI0652228T1 (en) |
| SK (1) | SK281120B6 (en) |
| TW (1) | TW380129B (en) |
| ZA (1) | ZA943266B (en) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1007183A3 (en) * | 1993-06-18 | 1995-04-18 | Solvay | Ureines DERIVED ALPHA, OMEGA-diamino AND METHOD FOR THEIR PREPARATION. |
| EP0809492A4 (en) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US6005008A (en) * | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
| US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| IL127666A0 (en) * | 1996-06-27 | 1999-10-28 | Smithkline Beecham Corp | IL-8 receptor antagonists |
| BR9709938A (en) | 1996-06-27 | 1999-08-10 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| WO1998006398A1 (en) * | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| US6492370B1 (en) | 1998-03-26 | 2002-12-10 | Santen Pharmaceutical Co., Ltd. | Urea derivatives and pharmaceutical compositions thereof |
| US7465754B1 (en) | 1999-09-15 | 2008-12-16 | Wyeth | Method of potentiating chemotherapy and treating solid tumors |
| KR101208266B1 (en) * | 2002-03-22 | 2012-12-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Hemiasterlin derivatives and uses thereof |
| US7332158B2 (en) * | 2002-05-29 | 2008-02-19 | Demao Yang | Compositions and treatments for myelosuppression by ex vivo activated immune cells |
| US7048922B2 (en) * | 2002-05-29 | 2006-05-23 | Demao Yang | Stimulation of hematopoiesis by ex vivo activated immune cells |
| MY143477A (en) * | 2002-10-29 | 2011-05-31 | Smithkline Beecham Corp | Il-8 receptor antagonists |
| US20060057121A1 (en) * | 2004-09-10 | 2006-03-16 | Demao Yang | Compositions and treatments using ex vivo activated cells for myelosuppressed patients |
| UA98456C2 (en) * | 2006-04-21 | 2012-05-25 | Смитклайн Бичам Корпорейшн | Il-8 receptor antagonists |
| WO2007124423A2 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| CL2007001829A1 (en) * | 2006-06-23 | 2008-01-25 | Smithkline Beecham Corp | N- [4-Chloro-2-hydroxy-3- (piperazine-1-sulfonyl) phenyl] -n- (2-chloro-3-fluorophenyl) urea P-toluenesulfonate; preparation process; pharmaceutical composition; pharmaceutical combination; and use in the treatment of a disease mediated by chemokine il-8, such as asthma and epoc. |
| US10913922B2 (en) | 2012-03-30 | 2021-02-09 | Givaudan S.A. | N-acylated methionine derivatives as food flavoring compounds |
| KR102045591B1 (en) | 2012-03-30 | 2019-12-02 | 지보당 에스아 | N-acyl derivatives of gamma amino-butyric acid and beta alanine as food flavouring compounds |
| SG11201405104PA (en) | 2012-03-30 | 2014-10-30 | Givaudan Sa | Improvements in or relating to organic compounds |
| WO2013149025A1 (en) * | 2012-03-30 | 2013-10-03 | Givaudan, S., A. | N-acyl serine derivatives as food flavouring compounds |
| US10582715B2 (en) | 2012-03-30 | 2020-03-10 | Givaudan Sa | Powder flavour composition |
| JP6224072B2 (en) | 2012-03-30 | 2017-11-01 | ジボダン エス エー | N-acyl-amino acid derivatives for improving flavor profile edible compositions |
| KR102045592B1 (en) | 2012-03-30 | 2019-11-15 | 지보당 에스아 | N-acyl proline derivatives as food flavouring compounds |
| KR102045590B1 (en) | 2012-03-30 | 2019-11-15 | 지보당 에스아 | N-acylated 1-aminocycloalkyl carboxylic acids as food flavouring compounds |
| GB201317424D0 (en) * | 2013-10-02 | 2013-11-13 | Givaudan Sa | Improvements in or relating to organic compounds |
| CN105592720B (en) | 2013-10-02 | 2020-07-07 | 奇华顿股份有限公司 | Organic compounds with taste-improving properties |
| CN105636459A (en) | 2013-10-02 | 2016-06-01 | 奇华顿股份有限公司 | Organic compounds |
| CN105592719B (en) | 2013-10-02 | 2020-03-10 | 奇华顿股份有限公司 | organic compounds |
| EP3052472B1 (en) | 2013-10-02 | 2019-02-27 | Givaudan S.A. | N-acylated 2-aminoisobutyric acid compounds and flavour compositions containing them |
| WO2015050535A1 (en) | 2013-10-02 | 2015-04-09 | Givaudan S.A. | Organic compounds |
| US10834943B2 (en) | 2013-10-02 | 2020-11-17 | Givaudan S.A. | Organic compounds having taste-modifying properties |
| US10537127B2 (en) | 2013-10-02 | 2020-01-21 | Givaudan S.A. | Organic compounds |
| JP7399846B2 (en) | 2017-08-21 | 2023-12-18 | セルジーン コーポレイション | Preparation process of (S)-TERT-butyl 4,5-diamino-5-oxopentanoate |
| CN109601739B (en) * | 2019-01-17 | 2022-10-14 | 河南湾流生物科技有限公司 | A kind of compound amino acid feed additive and preparation method thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2033906B (en) * | 1978-10-19 | 1982-12-01 | Anvar | Water-soluble compounds derived from extracts of streptomyces stimulosus process for their production and compositions containing them |
| US4725582A (en) * | 1978-11-14 | 1988-02-16 | Fujisawa Pharmaceutical Company, Ltd. | Peptide, process for preparation thereof and use thereof |
| US4349466A (en) * | 1978-11-14 | 1982-09-14 | Fujisawa Pharmaceutical Co | Peptide, process for preparation thereof and use thereof |
| FR2460290A1 (en) * | 1979-06-29 | 1981-01-23 | Rhone Poulenc Ind | NOVEL TETRA- OR PENTAPEPTIDES, THEIR PREPARATION AND THE MEDICINES THAT CONTAIN THEM |
| ES8604609A1 (en) * | 1985-07-02 | 1986-02-01 | Uriach & Cia Sa J | Process for the preparation of 1-[N-[1(R,S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline |
| AU664210B2 (en) * | 1991-09-27 | 1995-11-09 | Board Of Regents, The University Of Texas System | Amino acids containing parenteral formulations for the treatment of hypotension and related pathologies |
-
1993
- 1993-05-12 US US08/063,174 patent/US5312831A/en not_active Expired - Lifetime
-
1994
- 1994-03-14 US US08/213,303 patent/US5545662A/en not_active Expired - Lifetime
- 1994-04-20 DE DE69400798T patent/DE69400798T2/en not_active Expired - Fee Related
- 1994-04-20 ES ES94106123T patent/ES2094004T3/en not_active Expired - Lifetime
- 1994-04-20 DK DK94106123.6T patent/DK0652228T3/en active
- 1994-04-20 AT AT94106123T patent/ATE144533T1/en not_active IP Right Cessation
- 1994-04-20 SG SG1996003270A patent/SG43071A1/en unknown
- 1994-04-20 SI SI9430017T patent/SI0652228T1/en not_active IP Right Cessation
- 1994-04-20 EP EP94106123A patent/EP0652228B1/en not_active Expired - Lifetime
- 1994-04-22 CZ CZ1994981A patent/CZ290445B6/en not_active IP Right Cessation
- 1994-04-28 SK SK491-94A patent/SK281120B6/en unknown
- 1994-05-06 HU HU9401444A patent/HU219768B/en not_active IP Right Cessation
- 1994-05-09 IL IL10960294A patent/IL109602A/en not_active IP Right Cessation
- 1994-05-09 JP JP11953294A patent/JP3583469B2/en not_active Expired - Fee Related
- 1994-05-10 CA CA002123261A patent/CA2123261A1/en not_active Abandoned
- 1994-05-11 PL PL94303396A patent/PL179984B1/en not_active IP Right Cessation
- 1994-05-11 AU AU63043/94A patent/AU669064B2/en not_active Ceased
- 1994-05-11 ZA ZA943266A patent/ZA943266B/en unknown
- 1994-05-11 NO NO19941786A patent/NO311223B1/en unknown
- 1994-05-11 NZ NZ260507A patent/NZ260507A/en unknown
- 1994-05-11 RU RU94016389A patent/RU2135515C1/en not_active IP Right Cessation
- 1994-05-11 PH PH48247A patent/PH30182A/en unknown
- 1994-05-11 FI FI942186A patent/FI942186A7/en not_active Application Discontinuation
- 1994-05-11 KR KR1019940010317A patent/KR100296543B1/en not_active Expired - Fee Related
- 1994-05-12 CN CN94105671A patent/CN1094943C/en not_active Expired - Fee Related
- 1994-08-13 TW TW083107431A patent/TW380129B/en not_active IP Right Cessation
-
1995
- 1995-05-25 US US08/451,085 patent/US5633280A/en not_active Expired - Lifetime
- 1995-05-25 US US08/449,968 patent/US5658945A/en not_active Expired - Lifetime
- 1995-05-25 US US08/449,878 patent/US5602275A/en not_active Expired - Lifetime
- 1995-05-25 US US08/451,099 patent/US5616612A/en not_active Expired - Lifetime
-
1997
- 1997-01-09 GR GR970400020T patent/GR3022253T3/en unknown
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