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RU93005087A - 3- (TIAZOLIDINILBUTYL-4-PIPERAZINYL) -IH-INDAZOLES - Google Patents

3- (TIAZOLIDINILBUTYL-4-PIPERAZINYL) -IH-INDAZOLES

Info

Publication number
RU93005087A
RU93005087A RU93005087/04A RU93005087A RU93005087A RU 93005087 A RU93005087 A RU 93005087A RU 93005087/04 A RU93005087/04 A RU 93005087/04A RU 93005087 A RU93005087 A RU 93005087A RU 93005087 A RU93005087 A RU 93005087A
Authority
RU
Russia
Prior art keywords
lower alkyl
piperazinyl
hydrogen
cyclopentane
cyclohexane
Prior art date
Application number
RU93005087/04A
Other languages
Russian (ru)
Other versions
RU2105765C1 (en
Inventor
Дж. Хриб Николас
Т. Струпжевски Джозеф
Г. Джеркэк Джон
Бордо Кеннет
Original Assignee
Хехст-Рассел Фармасьютикалз Инкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/526,089 external-priority patent/US5041445A/en
Application filed by Хехст-Рассел Фармасьютикалз Инкорпорейтед filed Critical Хехст-Рассел Фармасьютикалз Инкорпорейтед
Publication of RU93005087A publication Critical patent/RU93005087A/en
Application granted granted Critical
Publication of RU2105765C1 publication Critical patent/RU2105765C1/en

Links

Claims (1)

Изобретение относится к 3-/1-тиазолидинил-бутил-4-пиперазинил/-1H-инда-золам формулы (1)
Figure 00000001

где R1 и R2 каждый независимо представляет собой водород или низший алкил, или R1 и R2, взятые вместе с атомом углерода, к которому они присоединены, образуют циклопентановое, циклогексановое или циклогептановое кольцо; R3 и R4 независимо представляют водород или низший алкил, или R3 и R4 взятые вместе с атомом углерода, к которому присоединены, образуют у циклопентановое, циклогексановое или циклогептановое кольцо; R5 представляет собой водород, низший алкил, алканоил или ароил; X представляет галоген, низший алкил или алкокси; m - целое число от 0 до 3, к их фармацевтически приемлемым кислотно-аддитивным солям, и, когда это применимо, к оптическим, геометрическим и стереоизомерам и их рацемическим смесям. Соединения могут быть полезными в качестве антипсихотических агентов.The invention relates to 3- / 1-thiazolidinyl-butyl-4-piperazinyl / -1H-indazole of the formula (1)
Figure 00000001

where R 1 and R 2 each independently represents hydrogen or lower alkyl, or R 1 and R 2 , taken together with the carbon atom to which they are attached, form a cyclopentane, cyclohexane or cycloheptane ring; R 3 and R 4 independently represent hydrogen or lower alkyl, or R 3 and R 4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane or cycloheptane ring; R 5 is hydrogen, lower alkyl, alkanoyl, or aroyl; X represents halogen, lower alkyl or alkoxy; m is an integer from 0 to 3, to their pharmaceutically acceptable acid addition salts, and, when applicable, to optical, geometric and stereoisomers and their racemic mixtures. The compounds may be useful as antipsychotic agents.
RU93005087A 1990-05-21 1993-05-18 3-(thiazolidenylbutyl-4-piperazinyl)-1h-indazoles RU2105765C1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/526,089 US5041445A (en) 1990-05-21 1990-05-21 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US526089 1990-05-21

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU4895498 Division

Publications (2)

Publication Number Publication Date
RU93005087A true RU93005087A (en) 1996-01-27
RU2105765C1 RU2105765C1 (en) 1998-02-27

Family

ID=24095872

Family Applications (2)

Application Number Title Priority Date Filing Date
SU914895498A RU2038355C1 (en) 1990-05-21 1991-05-20 Method of synthesis of 3-(1-thiazolidinylbutyl-4-piperazinyl)-1h-indazoles
RU93005087A RU2105765C1 (en) 1990-05-21 1993-05-18 3-(thiazolidenylbutyl-4-piperazinyl)-1h-indazoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU914895498A RU2038355C1 (en) 1990-05-21 1991-05-20 Method of synthesis of 3-(1-thiazolidinylbutyl-4-piperazinyl)-1h-indazoles

Country Status (23)

Country Link
US (1) US5041445A (en)
EP (1) EP0458234B1 (en)
JP (1) JP3161755B2 (en)
KR (1) KR100215616B1 (en)
AT (1) ATE178327T1 (en)
AU (1) AU642243B2 (en)
CA (1) CA2042982A1 (en)
CZ (1) CZ280005B6 (en)
DE (1) DE69131057T2 (en)
DK (1) DK0458234T3 (en)
ES (1) ES2130125T3 (en)
FI (1) FI94757C (en)
GR (1) GR3030233T3 (en)
HU (1) HU215845B (en)
IE (1) IE911708A1 (en)
IL (1) IL98184A (en)
MX (1) MX25858A (en)
NO (1) NO179749C (en)
NZ (1) NZ238184A (en)
PL (1) PL165731B1 (en)
PT (1) PT97720B (en)
RU (2) RU2038355C1 (en)
ZA (1) ZA913794B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052675T3 (en) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3- (4-PIPERAZINIL-SUBSTITUTED IN 1) BUTIL) -4-THIAZOLIDINONAS, A PROCEDURE FOR ITS PREPARATION AND USE AS MEDICINES.
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
CA2157348A1 (en) * 1994-09-01 1996-03-02 Aventis Pharmaceuticals Inc. 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds
WO2007098418A1 (en) * 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-ht6 receptor affinity
WO2009023844A2 (en) * 2007-08-15 2009-02-19 Memory Pharmaceuticals Corporation 3' substituted compounds having 5-ht6 receptor affinity
US20100016297A1 (en) * 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100029629A1 (en) * 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) * 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
JP5760300B2 (en) 2009-09-10 2015-08-05 株式会社リコー Inkjet ink composition material and inkjet ink composition

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100282A (en) * 1972-12-23 1978-07-11 Boehringer Ingelheim Gmbh N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof
DE3132916A1 (en) * 1981-08-20 1983-03-03 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-PHENYLINDAZOL-3-ON COMPOUNDS, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4775761A (en) * 1983-08-22 1988-10-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
US4732984A (en) * 1985-10-17 1988-03-22 American Home Products Corporation Piperazinoisothiazolones with psychotropic activity
EP0302423A3 (en) * 1987-08-07 1991-01-09 Hoechst-Roussel Pharmaceuticals Incorporated 1-phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments
ES2052675T3 (en) * 1987-11-20 1994-07-16 Hoechst Roussel Pharma 3- (4-PIPERAZINIL-SUBSTITUTED IN 1) BUTIL) -4-THIAZOLIDINONAS, A PROCEDURE FOR ITS PREPARATION AND USE AS MEDICINES.
NZ230045A (en) * 1988-08-05 1990-11-27 Janssen Pharmaceutica Nv 3-piperazinylbenzazole derivatives and pharmaceutical compositions
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles

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