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RU93004680A - METHOD OF OBTAINING 4-METHYL-2'-CYANOBIFENYL - Google Patents

METHOD OF OBTAINING 4-METHYL-2'-CYANOBIFENYL

Info

Publication number
RU93004680A
RU93004680A RU93004680/04A RU93004680A RU93004680A RU 93004680 A RU93004680 A RU 93004680A RU 93004680/04 A RU93004680/04 A RU 93004680/04A RU 93004680 A RU93004680 A RU 93004680A RU 93004680 A RU93004680 A RU 93004680A
Authority
RU
Russia
Prior art keywords
methyl
cyanobifenyl
obtaining
halobenzonitrile
cyanobiphenyl
Prior art date
Application number
RU93004680/04A
Other languages
Russian (ru)
Other versions
RU2102384C1 (en
Inventor
Буиссе Мишель
Будэн Ален
Original Assignee
Елф.Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9204512A external-priority patent/FR2689887B1/en
Application filed by Елф.Санофи filed Critical Елф.Санофи
Publication of RU93004680A publication Critical patent/RU93004680A/en
Application granted granted Critical
Publication of RU2102384C1 publication Critical patent/RU2102384C1/en

Links

Claims (1)

Изобретение касается способа получения 4-метил-2'-цианобифенила, заключающегося в том, что подвергают взаимодействию, в присутствии соли марганца II, галогенбензонитрил с металлорганическим соединением, с последующим гидролизом полученного комплекса, приводящим к образованию требуемого соединения.The invention concerns a process for the preparation of 4-methyl-2'-cyanobiphenyl, consisting in that it is reacted, in the presence of a manganese II salt, with a halobenzonitrile with an organometallic compound, followed by hydrolysis of the resulting complex, leading to the formation of the desired compound.
RU93004680/04A 1992-04-13 1993-04-12 Method of preparing 4-methyl-2-cyanobiphenyl RU2102384C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9204512A FR2689887B1 (en) 1992-04-13 1992-04-13 PROCESS FOR THE PREPARATION OF A BIPHENYL DERIVATIVE.
FR92-04512 1992-04-13
FR9204512 1992-04-13

Publications (2)

Publication Number Publication Date
RU93004680A true RU93004680A (en) 1996-06-20
RU2102384C1 RU2102384C1 (en) 1998-01-20

Family

ID=9428800

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93004680/04A RU2102384C1 (en) 1992-04-13 1993-04-12 Method of preparing 4-methyl-2-cyanobiphenyl

Country Status (27)

Country Link
US (1) US5288895A (en)
EP (1) EP0566468B1 (en)
JP (1) JP2930827B2 (en)
KR (1) KR100283066B1 (en)
AR (1) AR248010A1 (en)
AT (1) ATE148101T1 (en)
AU (1) AU656263B2 (en)
BR (1) BR9301514A (en)
CA (1) CA2093723C (en)
CZ (1) CZ282559B6 (en)
DE (1) DE69307577T2 (en)
DK (1) DK0566468T3 (en)
ES (1) ES2097466T3 (en)
FI (1) FI103666B1 (en)
FR (1) FR2689887B1 (en)
HU (1) HU212253B (en)
IL (1) IL105337A (en)
MX (1) MX9302123A (en)
MY (1) MY107763A (en)
NO (1) NO177637C (en)
NZ (1) NZ247372A (en)
PH (1) PH30349A (en)
RU (1) RU2102384C1 (en)
SK (1) SK280581B6 (en)
TW (1) TW225516B (en)
UA (1) UA27104C2 (en)
ZA (1) ZA932589B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928982B2 (en) 1994-10-27 1999-08-03 住化ファインケム株式会社 Method for producing 4'-bromomethyl-2-cyanobiphenyl
DE19607135C1 (en) * 1996-02-26 1997-04-24 Great Lakes Chem Konstanz Gmbh Prodn. of asymmetric cyano-bi:phenyl cpds.
FR2753195B1 (en) * 1996-09-09 1998-11-27 Sanofi Sa PROCESS FOR THE PREPARATION OF A CYANOBIPHENYL
FR2753705B1 (en) 1996-09-20 1999-08-06 PROCESS FOR THE PREPARATION OF 4-METHYL-BIPHENYL DERIVATIVES
US5892094A (en) * 1997-01-08 1999-04-06 Sumika Fine Chemicals Co., Ltd. Process for preparing 4'-methyl-2-cyanobiphenyl
US5998652A (en) * 1997-01-21 1999-12-07 Sumika Fine Chemicals Co., Ltd. Process for preparing 2-cyanobiphenyl compound
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
US6162922A (en) * 1998-01-30 2000-12-19 Bristol-Myers Squibb Co. Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst
FR2776658B3 (en) 1998-03-24 2000-05-26 Sanofi Sa METHYL-BIPHENYL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE
US5874606A (en) * 1998-03-31 1999-02-23 Occidental Chemical Corporation Process for making o-arylbenzonitriles
EP0976736A1 (en) * 1998-07-29 2000-02-02 SUMIKA FINE CHEMICALS Co., Ltd. Production method of 2-(p-alkylphenyl)pyridine compound
US6962999B2 (en) * 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
WO2003106406A1 (en) * 2002-06-12 2003-12-24 住化ファインケム株式会社 Process for producing 4'-bromomethyl-2-cyanobiphenyl
US7105467B2 (en) * 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) * 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
CN102964271B (en) * 2012-12-03 2014-05-14 齐鲁工业大学 Synthesis method of sartan anti-hypertensive medicament intermediate 2-cyan-4'-methyl diphenyl
CN103012201B (en) * 2012-12-03 2014-07-30 滕州市悟通香料有限责任公司 Synthetic method of 2-cyano-4'-methyl diphenyl
CN103012202B (en) * 2012-12-04 2014-10-08 山东鑫泉医药有限公司 Preparation method of sartanbiphenyl
CN103467341B (en) * 2013-08-29 2015-02-25 河南师范大学 Preparation method for 2-cyano-4'-methylbiphenyl
CN105017025B (en) * 2014-04-22 2018-06-12 浙江省化工研究院有限公司 The preparation method of one kind 4 '-chloro- 2 nitro biphenyl
CN104326938B (en) * 2014-10-22 2016-08-17 陕西煤业化工技术开发中心有限责任公司 A kind of method using benzimidazole ionic liquid to prepare sartanbiphenyl

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2590252B3 (en) * 1985-11-19 1988-09-09 Rolland Sa A NOVEL PROCESS FOR OBTAINING AMINONITRILES AND THEIR APPLICATIONS IN ORGANIC SYNTHESIS
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
DE3816120A1 (en) * 1988-05-11 1989-11-23 Bayer Ag METHOD FOR PRODUCING UNBALANCED BIARYL COMPOUNDS
IE910913A1 (en) * 1990-03-20 1991-09-25 Sanofi Sa N-substituted heterocyclic derivates, their preparation¹and pharmaceutical compositions containing them
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process

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