RU3548U1 - DEVICE FOR ADMINISTRATION OF MEDICINES - Google Patents

Abstract

1. A device for introducing drugs into the body cavity, containing a reservoir for medicinal fluid with a flexible tube for dispensing the latter, characterized in that it further comprises a handle plate for holding the device in the body cavity, connected through at least one flexible tube made of semi-permeable fiber membranes that ensure the diffusion of drug fluid with a molecular weight of 15,000 or lower only from the lumen of the fiber to the outside. 2. The device according to claim 1, characterized in that the number of flexible tubes is determined by the formula n = K <Mv> t <D> <195> S <Mv> o <D> <Mv> r <D> / h, where n is the number flexible tubes required to deliver the drug at therapeutic concentrations; K <Mv> t <D> is the amount of drug per unit of surface to be treated at the desired therapeutic concentration; S <Mv> o <D> <Mv> r <D> is the surface area to be treated; h is the depth of the lesion, and the total cross-sectional area of the flexible tubes should not exceed the base area of the medicinal fluid container. 3. The device according to claims 1 and 2, characterized in that the semipermeable fiber membranes are made of polyaromatic phenylone polymer.

Description

DEVICE FOR ADMINISTRATION OF MEDICINES.

The invention relates to the inventions of medical equipment and can be used in the treatment of diseases of the rectum or pelvic organs.

Widely known are swabs impregnated with a drug substance that are administered into the inflammatory or postoperative cavities of a patient. As a rule, cotton swabs are used for tampons.

The disadvantage of tampons is the impossibility of a uniform flow of drugs into the area of wounds or inflammation. An overdose of drugs in the first hours of the swab adversely affects the cell membrane, and a drop in concentration in the next hours of the drug reduces the effect of treatment. When treating wounds by plugging, the tampon ceases to function after 2-6 hours. In addition, the coarse texture of the cotton tissue promotes the ingrowth of granulation tissue between the fibers of the tissue, which causes an additional injury to the wound surface when tampons are removed.

The closest analogue of the proposed device for the introduction of liquid medicinal substances into the body cavity is a device (see US patent No. 3765415 MKI A 61 M 31/00) containing a flexible container for medicinal fluid and a flexible tube for dispensing, and the flexible container is placed in a case made with the possibility of reducing the volume, which provides pressure on the elastic container and, accordingly, the flow of medicine into the cavity.

During treatment, the flexible tube is placed in a pathological focus in the body cavity, and the container is placed outside, from which, through the open end of the flexible tube, the drug substance is fed through the case through the open end.

The known device does not solve the problem of uniformly supplying the drug substance to the wound cavity, since it does not provide a mechanism for providing a uniform effect on the flexible container and does not allow the drug to treat the entire surface of the inflammatory zone without drug overdose.

MKIA61M31 / 00

The proposed device allows long-term maintenance of therapeutic concentration of drugs in the pathological focus through the use of membranes as a material for irrigation of the wound.

The problem is solved by a device containing a container for medicinal fluid, equipped with flexible tubes for dispensing it, made of semipermeable fiber membranes that ensure diffusion of the medicinal fluid only from the lumen of the fiber to the outside with a molecular weight of 15 thousand or lower, and at least one of the flexible the tubes are connected to the handle plate to hold the device in the body cavity.

The number of flexible tubes is determined by the amount of medicinal fluid supplied, depends on the area of the treated surface, the speed of the drug and the depth of the lesion and is equal to n CT x S or / h, where

p - the number of flexible tubes required to supply the drug in therapeutic concentrations;

CT - the amount of drug per unit of the treated surface, the required therapeutic concentration;

S or - area of the treated surface;

h is the depth of the lesion, and the total cross-sectional area of the flexible tubes should not exceed the base area of the area of the container for medicinal fluid.

The amount of drug per unit of surface to be treated at the required therapeutic concentration is ensured by the speed of the drug through semipermeable fiber membranes and the surface area of the flexible tube made from it.

Flexible tubes are mounted in the handle at an angle of 90 ° to its surface,

For the manufacture of a device for the introduction of liquid medicinal substances, the following materials are used: polyvinyl chloride or medical rubber for the manufacture of a container for a medicinal fluid and a plate-horn.

Hollow phenylone fibers, for example, VPU-15 grades for flexible tubes. VPU-15 brand hollow phenyl-fiber is produced by NPO Khimvolokno. VPO-15 fibers are biologically inert, stable in aqueous solutions at pH 1-13, can be autoclaved, hydrophilic, their surface is smooth, fibers are elastic, inner diameter is 0.8-1 mm, wall thickness is 0.1 mm.

In FIG. 1 - device for the introduction of liquid medicinal substances held in space (retention means not shown).

In FIG. 2 - a device located in the patient’s body.

The device includes hollow flexible tubes 1 for supplying medicinal fluid from semipermeable fiber membranes, for example, a phenylar polyaromatic polymer, connected to a medicinal fluid container 2, which is connected by at least one flexible tube 1 to the handle plate 3.

The device operates as follows: the container 2 is filled with medicinal fluid through the lumen of the flexible tube 1, the end of which is then sealed. A mirror is inserted into the rectum (not shown in Fig.) Through which a device for administering drugs is placed in the lesion. The mirror is removed, flexible tubes 1 are fixed in the anal canal. The container 2 is held in the rectum due to the contraction of the anal sphincter, its displacement into the lumen of the rectum is held by the plate - the handle 3, connected through flexible tubes 1.

Patient Nm 38 years old, was admitted to the proctology department for chronic hemorrhoids in combination with posterior intrasphincter pararectal fistula. After a preoperative examination and preparation, the patient was operated on - a pararectal fistula was excised, hemorrhoidectomy according to Milligan-Morgan according to method II of the Research Institute of Proctology with our modifications. At the end of the operation, the above device was inserted into the rectum using a rectal mirror. Previously, the device’s container was filled with a cocktail of drugs dissolved in an isotonic sodium chloride solution (trimecaine, kanamycin, vikasol). This device was in the rectum for 3 days, after which the device was removed by the usual pulling by the handle. Made a cleansing enema. During the patient’s period, antibiotics and painkillers were not injected; the device provided a therapeutic effect by diffusing the drug mixture into the pathological focus. Subsequently, the patient underwent dressings by conventional methods. The patient was discharged on the 8th day after the operation. The wounds healed by primary intention.

The patient was examined after 3 months. No complaints. A local examination in the anal canal has tender, painless postoperative scars.

Claims (3)

1. A device for introducing drugs into the body cavity, containing a reservoir for medicinal fluid with a flexible tube for dispensing the latter, characterized in that it further comprises a handle plate for holding the device in the body cavity, connected through at least one flexible tube made of semi-permeable fiber membranes that ensure the diffusion of drug fluid with a molecular weight of 15,000 or lower only from the lumen of the fiber to the outside. 2. The device according to p. 1, characterized in that the number of flexible tubes is determined by the formula
n = K <Mv> t <D><195> S <Mv> o <D><Mv> r <D> / h,
where n is the number of flexible tubes required to deliver the drug at therapeutic concentrations;
K <Mv> t <D> - the amount of medication per unit of the treated surface of the desired therapeutic concentration;
S <Mv> o <D><Mv> r <D> - the area of the treated surface;
h is the depth of the lesion, and the total cross-sectional area of the flexible tubes should not exceed the base area of the container for medicinal fluid.  3. The device according to claims 1 and 2, characterized in that the semipermeable fiber membranes are made of a polyaromatic phenylone polymer.