RU2838619C2 - Inhaler for use with cartridge comprising blocks of starting material inside cartridge body - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to medical equipment, namely to an inhaler for use with a cartridge containing blocks of initial material inside the cartridge body. Inhaler comprises blocks of the starting material inside the cartridge body. Inhaler comprises an inhaler body forming a cavity for receiving a cartridge, and a rotating gear located on the surface of the cavity for receiving the cartridge, in which the cartridge is installed, or directly under it. Rotary gear is made with possibility of rotation of cartridge when it is inserted to move blocks of initial material, at least one displacement member configured to move between a proximal position within the inhaler and a distal position, in which it is configured to reach the cartridge when the cartridge is loaded into the inhaler to initiate movement of the starting material unit to the use position in the inhaler. Distal end of the transfer element has a shape for attachment to the connecting element of the cartridge.

EFFECT: providing an inhaler for use with a cartridge comprising a plurality of starting material units.

13 cl, 15 dwg

Description

Related applications

This application claims priority to U.S. Provisional Patent Application No. 62/751,636, filed October 28, 2018, the contents of which are incorporated herein by reference in their entirety.

Field of technology and Prior art of the present invention

In some embodiments, the present invention relates to a cartridge of starting material for use with an inhaler, and more particularly, but not exclusively, to moving a block of starting material from the cartridge to a position for use within and/or from the inhaler.

U.S. Patent No. 9,802,011, owned by the assignee of the present invention, discloses: "described are devices and methods for receiving, controlling and/or administering metered doses of substances for administration in a vapor state. In some embodiments, single-dose cartridges containing at least one herbal substance comprise a heating element embedded in the cartridge in close contact with the herbal substance. In some embodiments, the doses contained in the cartridge are stored in a cassette, optionally a carousel, prior to use. Transport of the cartridge from the cassette to a vaporization chamber with an electrical drive that activates the heating element is accomplished by mechanical gripping means." (Abstract).

Brief summary of the present invention

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises: a plurality of blocks of source material; and a block connecting element configured to selectively connect to each of the blocks of source material such that, when the cartridge is operatively attached to the inhaler, manipulation of the block connecting element moves the attached block of source material out of the cartridge or back into the cartridge; wherein the block connecting element and each of the blocks of source material are formed with a geometry for connection in which a projection of one enters into a corresponding recess of the other.

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises: a housing comprising: a plurality of source material blocks; and a block connecting element configured to selectively connect with each of the source material blocks, wherein the block connecting element is located and configured to move from the housing or back into it with the source material block connected; wherein the block connecting element and each of the source material blocks are formed with a geometry for connection in which a projection of one enters into a corresponding recess of the other.

In some embodiments, the block connecting element comprises a distal projection with a shape and size for installation inside a corresponding recess formed in each of the source material blocks. In some embodiments, the cartridge body has a geometry defining two movement paths: a first path, in which a plurality of source material blocks are configured to slide past the block connecting element; and a second path, in which a source material block that was connected to the block connecting element on the first path is configured to move together with the block connecting element along the second path. In some embodiments, the first path is configured to rotate the source material blocks relative to the block connecting element; and the second path is configured to move the connected block connecting element and the source material block together linearly. In some embodiments, a plurality of source material blocks are located on a carousel and can rotate relative to the block connecting element; wherein the block connecting element is located radially outward relative to the carousel. In some embodiments, the block connecting element is located in a passage of the cartridge body. In some embodiments, the block connecting element is linearly aligned with the moving element when the cartridge is installed in the final position relative to the inhaler. In some embodiments, the outer side of the cartridge housing is formed with a bulge, and at least a part of the block connecting element extends into the bulge on the inner side of the bulge. In some embodiments, the housing is substantially rounded, and the bulge is located so as to align the cartridge relative to the said cavity in the inhaler, in which the cartridge is inserted. In some embodiments, the block connecting element at a given time connects only one block of the starting material, and only this block of the starting material can be removed from the cartridge or returned back to the cartridge. In some embodiments, the bulge forms a passage having a width that corresponds to the thickness of the block of the starting material, so that only one block of the starting material can pass through the passage at a given time. In some embodiments, the cartridge comprises a limiting frame that moves between a first position, in which it prevents the block coupling from moving out of the cartridge, and a second position, in which the opening of the limiting frame is aligned with the block coupling to ensure its movement. In some embodiments, the inhaler for use with the source material cartridge comprises a moving element with a shape and size for engaging the block coupling to draw the source material block into a position for use inside the inhaler body. In some embodiments, the distal end of the moving element has a shape for attachment to the cartridge block coupling by means of a sliding fit connection. In some embodiments, the distal end of the moving element is T-shaped. In some embodiments, the moving element can slide on the shaft between the proximal and distal positions. In some embodiments, the movement of the moving element on the shaft is initiated by rotation of the screw from the motor. In some embodiments, the moving element comprises a distal head formed by one or more inclined surfaces with a shape and size for guiding the insertion of the cartridge into said cavity of the inhaler. In some embodiments, the moving element, the connecting element of the block and the block of the starting material are linearly aligned with each other when the cartridge is in the connected position relative to the inhaler.

According to an aspect of some embodiments, a method for extracting a block of raw material from a cartridge configured to be used with an inhaler is presented, wherein the method comprises: loading into the inhaler a cartridge comprising a plurality of blocks of raw material and a block connecting element configured to be connected to one of the blocks of raw material; and connecting the cartridge to the inhaler, simultaneously engaging at the same time the block connecting element in preparation for drawing in the connected block of raw material into a position for use inside the inhaler. In some embodiments, the block connecting element in the presented cartridge is connected to the block of raw material before loading into the inhaler. In some embodiments, connecting the block of raw material to the block connecting element is performed simultaneously with connecting the cartridge to the inhaler. In some embodiments, loading the cartridge includes releasing the limiting frame of the cartridge to allow the block connecting element to move from a position in which its movement is restricted to a position in which its movement is allowed from the cartridge or into it. In some embodiments, the method further comprises returning the block of raw material back into the cartridge after its use. In some embodiments, engaging the connecting element of the block involves moving the moving element of the inhaler to a position in which the moving element is connected to the connecting element of the block. In some embodiments, the moving element moves the block of the starting material to a position for use, in which the block of the starting material is in communication with the air flow channel of the inhaler. In some embodiments, the moving element moves the block of the starting material to a position for use, in which heat or an electric current is applied to the block of the starting material to release at least one active substance from the starting material. In some embodiments, loading the cartridge includes aligning the cartridge relative to the cavity of the inhaler. In some embodiments, locking the cartridge relative to the inhaler linearly aligns the moving element of the inhaler with the connecting element of the cartridge block.

According to an aspect of some embodiments, an inhaler is provided for use with a cartridge of starting material comprising a plurality of blocks of starting material; wherein the inhaler comprises a moving element configured to move between a proximal position within the inhaler and a distal position in which it is configured to reach the cartridge when the cartridge is loaded into the inhaler, to initiate movement of the block of starting material into the position for use in the inhaler; wherein the distal end of the moving element is shaped and located relative to the loaded cartridge such that rotation of the cartridge does not break or otherwise damage the moving element. In some embodiments, a kit is provided, comprising an inhaler and a cartridge comprising a plurality of blocks of starting material and a block connecting element configured to selectively connect with each of the blocks of starting material. In some embodiments, the moving element is configured to connect with the block connecting element when the moving element is in the distal position. In some embodiments, the cartridge is substantially rounded and includes a bulge, and the distal end of the moving member in the distal position extends adjacent to a recess in which the bulge of the cartridge is located.

According to an aspect of some embodiments, a kit is provided comprising an inhaler and a cartridge of raw material for use with the inhaler, wherein the cartridge comprises an RFID tag, and the inhaler is configured to read and write to the RFID tag of the cartridge data relating to the use of blocks of raw material of the cartridge.

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises: a housing comprising: a plurality of blocks of starting material arranged on a carousel; and a protrusion located on the outer side of the housing, wherein the protrusion is arranged so as to limit the rotation of the carousel, when the cartridge is in the inhaler, in at least one of a clockwise direction and a counterclockwise direction; wherein the rotation is limited to an angular position in which each block of starting material can be available for use only once.

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises a plurality of blocks of starting material arranged on a carousel; wherein the rotation of the carousel is limited in at least one of a clockwise direction and a counterclockwise direction to such an extent that the first block of starting material does not pass, to prevent approaching blocks of starting material that have already been used. In some embodiments, the rotation of the carousel is limited in both directions, both clockwise and counterclockwise.

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises a plurality of starting material blocks arranged in slots of a carousel; wherein one or more of the last 10% of the slots on the carousel comprises an indicator for identifying that the cartridge has been completely used. In some embodiments, the indicator comprises an empty slot that does not contain a starting material block. In some embodiments, the indicator comprises a block that does not contain an electrically conductive element. Optionally, the block is otherwise indicated as an indicator (e.g., by having a significantly lower or higher resistance to electrical current than the starting material block or by resisting removal from the slot, and/or by having a different color and/or shape that can be detected by an optical sensor or the like).

According to an aspect of some embodiments, a cartridge for use with an inhaler is provided, wherein the cartridge comprises: a plurality of blocks of starting material arranged on a carousel; and a limiter comprising one or more teeth that extends between adjacent blocks of starting material, preventing rotation of the carousel.

According to an aspect of some embodiments, a cartridge for use in an inhaler is provided, wherein the cartridge comprises a housing; a plurality of raw material blocks stacked or aligned with the possibility of rotation relative to the housing; at least one indicator located between adjacent raw material blocks. In some embodiments, the cartridge is a packaged, airtight cartridge, and at least one indicator is placed during the manufacturing process of the cartridge. In some embodiments, the indicator comprises an empty seat or a raw material block having a design different from the design of at least 70% of the total number of raw material blocks in the cartridge. In some embodiments, the cartridge comprises an RFID tag that comprises or is configured to record data corresponding to one or more of: the use of raw material blocks, the content of the raw material blocks, the relative position of at least one indicator relative to the housing, the relative position of each of the plurality of raw material blocks relative to the indicator. In some embodiments, an inhaler device is provided, configured to receive the cartridge, wherein the inhaler comprises: a cavity with a shape and size for receiving the cartridge therein; a controller configured to determine a relative position of one or more blocks of the cartridge starting material based on the position of the indicator. In some embodiments, the controller determines the position of the indicator based on signals received from at least one of the optical sensor and the electrical resistance sensor. In some embodiments, the inhalation device comprises a circuit configured to read and write data to an RFID tag of the cartridge, and a controller configured to determine whether the current position of the indicator correlates with the data of the RFID tag to check the position of the cartridge in the cavity of the inhaler.

According to an aspect of some embodiments, a method is provided for identifying a relative position of one or more blocks of raw material in a cartridge suitable for use with an inhalation device, comprising: attaching a cartridge to the inhalation device; identifying, by means of a diagram of the inhalation device, the location of the positions of one or more indicators in the cartridge or a structure comprising at least one empty slot and a plurality of blocks of raw material; and determining the relative position of the one or more blocks of raw material based on the identified position of the indicator or the structure that contains the indicator.

According to an aspect of some embodiments, an inhaler is provided for use with a cartridge containing a plurality of blocks of the starting material; wherein the inhaler comprises: a housing defining a cavity for receiving the cartridge, and a rotating gear formed on the surface of the cavity on which the cartridge is located, or directly below it, wherein the rotating gear is configured to initiate rotation of the cartridge upon insertion to move the plurality of blocks of the starting material. In some embodiments, the inhaler further comprises a projecting element that, upon contact with the door of the lid of the inhaler housing, moves the clutch into engagement with the rotating gear.

Unless otherwise defined, all technical and/or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, illustrative methods and/or materials are described below. In case of conflict, the patent specification, including definitions, will control. Furthermore, the materials, methods, and examples are illustrative only and are not intended to be limiting.

Brief description of the figures

Some embodiments of the invention are described herein by way of example only with reference to the accompanying figures. Further, with specific reference to the detailed figures, it should be emphasized that the details are shown by way of example and for the purpose of illustratively discussing the embodiments of the invention. In this regard, the description together with the figures makes it obvious to those skilled in the art how the embodiments of the invention can be put into practice. In the figures:

Fig. 1 is a block diagram of a system comprising an inhaler and a cartridge comprising a plurality of raw material blocks according to some embodiments;

Fig. 2 is a block diagram of a general method of using an inhaler configured to be operatively connected to a cartridge comprising a plurality of blocks of starting material and a block connecting element according to some embodiments;

Fig. 3 is a cross-sectional view of a mechanism for engaging a block of starting material contained in a cartridge according to some embodiments;

Fig. 4A-C show a detailed view of a part of the mechanism of Fig. 3 (Fig. 4A) and a detailed view of the moving element in the form of a slider (Fig. 4B, 4C) according to some embodiments;

Fig. 5A-B are a cross-sectional view of a mechanism, such as that shown in Fig. 3, and an isometric view of a block connector according to some embodiments;

Fig. (6A1-6B3) shows a side view (6A1, 6A2, 6A3) and an isometric view (6B1, 6B2, 6B3) of the process of placing a cartridge comprising a block connector and a plurality of blocks of starting material in a position of use, relative to an inhaler according to some embodiments;

Fig. 7A-C illustrate a method for extracting a block of source material from a cartridge according to some embodiments;

Fig. 8A-B illustrate a cartridge comprising a protrusion (8A) and a detailed view of the protrusion showing a connecting element of the block (8B) according to some embodiments.

Fig. 9A-B are illustrations of an inhaler comprising a cartridge, such as that shown in Fig. 8A-B, in an initially inserted position (Fig. 9A) and in a position of use (Fig. 9B), according to some embodiments;

Fig. 10A-C show different views of the cavity of the inhaler into which the cartridge of the starting material is inserted according to some embodiments;

Fig. 11A-C illustrates a limiting frame and a cartridge movement limiter in an attached position and a released position according to some embodiments;

Fig. 12 is a block diagram of a method for loading a cartridge in which the cartridge locking mechanisms are simultaneously released according to some embodiments;

Fig. 13 is a flow chart of a method for identifying a fully used cartridge according to some embodiments;

Fig. 14A-B show an internal view (Fig. 14A) and an external view (Fig. 14B) of a linear cartridge comprising a block connector according to some embodiments; and

Fig. 15A-C is a cross-sectional view of a cavity of an inhaler for receiving a cartridge comprising a sleeve and a gear mechanism (Fig. 15A) and components associated with the operation of the gear mechanism (Fig. 15B-C) according to some embodiments.

Detailed disclosure of the present invention

In some embodiments, the present invention relates to a cartridge of starting material for use with an inhaler, and more particularly, but not exclusively, to moving a block of starting material from the cartridge to a position for use within and/or from the inhaler.

An aspect of some embodiments of the invention relates to a cartridge for use with an inhaler, wherein the cartridge comprises a plurality of blocks of raw material and a block connecting element configured to engage a block of raw material. In some embodiments, the block connecting element is arranged such that it extends at least partially into the passage of the cartridge, so that when the cartridge is loaded into the inhaler, the block connecting element is accessible. In some embodiments, the block connecting element is attached to a first block of raw material, and after use of the block, the block is returned to the cartridge along with the block connecting element. Then, a plurality of blocks of raw material can be advanced inside the cartridge, placing other blocks of raw material with attachment to the block connecting element. Optionally, the position of the block connecting element remains constant while the blocks of raw material are moved relative to the block connecting element. Alternatively, the block connecting element moves relative to the blocks of raw material.

In some embodiments, the block connecting element is connected to the block of the source material using a fixed-fit connection, for example, in which a part of the block connecting element has a shape and size for being received inside a part of the block, or vice versa, in some embodiments, each of the source material blocks is formed with a geometric space with a shape and/or a size for receiving the block connecting element or a part thereof. In some embodiments, the block connecting element comprises a projection that extends inside a corresponding recess of the source material block, or vice versa, the source material block comprises a projection that extends inside a corresponding recess of the block connecting element. Other embodiments may include different types of connections between the block connecting element and the source material block, for example, a loose-fit connection, a sliding-fit connection, attachment using a third element (for example, a screw) and/or other types of connections.

In some embodiments, the block connector is connected to the first block of the starting material before loading the cartridge into the inhaler. A potential advantage of the first block of the starting material already being connected to the block connector may be that when loading the cartridge into the inhaler, the already connected block of the starting material may be immediately (automatically or in response to user activation) moved into position for use within the inhaler. Alternatively, the block connector of the cartridge is not initially attached to any of the blocks of the starting material. This may facilitate safe use of the cartridge and reduce the risk of misuse, since the process of removing the block of the starting material for use will require the additional step of connecting the block connector to the first block of the starting material, which may be performed simultaneously with or after loading the cartridge.

In some embodiments, the cartridge is configured to support two paths of movement: a first path in which the blocks of the starting material slide past the block connecting element until a selected block of the starting material is connected to the block connecting element; and a second path in which the connected block connecting element and the block of the starting material are moved together, for example, pulled into a position for use inside the inhaler or pushed back into the cartridge. In some embodiments, in the first path, the blocks of the starting material rotate inside the cartridge. In some embodiments, in the second path, the block connecting element and the connected block of the starting material move together along a linear axis, passing, for example, radially outward relative to the cartridge body. In some embodiments, the movement along the second path occurs in a plane substantially perpendicular to the movement along the first path.

An aspect of some embodiments of the invention relates to moving a block of raw material into and out of a position for use in an inhaler, wherein the movement is accomplished by assembling together elements of both the inhaler and the cartridge. In some embodiments, the block of raw material may be activated only after one or more elements of the inhaler, such as a moving element, have been operatively attached to a connecting element of the cartridge block.

In some embodiments, loading the cartridge into the inhaler and/or positioning the cartridge in said recess or cavity of the inhaler simultaneously connects the moving element of the inhaler to the connecting element of the cartridge block, which in turn (simultaneously or later) is attached to the block of the starting material. Some embodiments may provide more than one connecting element of the block, for example, two, three, five, ten connecting elements of the blocks or an intermediate greater or lesser number of connecting elements of the blocks. Optionally, a plurality of connecting elements of the blocks are used to assemble a plurality of blocks of the starting material at a given time. In some embodiments, the moving element of the inhaler is configured to connect to a plurality of connecting elements of the blocks. Alternatively, the inhaler comprises a plurality of moving elements, each of which is configured to engage a connecting element of the block.

In some embodiments, the cartridge is provided with a block connecting element already attached to the first block of the starting material. Optionally, loading the cartridge into the inhaler simultaneously engages the moving element with the block connecting element, and the first block of the starting material can be used immediately. Alternatively, the block connecting element and the first block of the starting material are connected only when loading the cartridge into the inhaler.

During operation, according to some embodiments, the moving element is configured to move (e.g. slide) to move the block of starting material to a position for use, in which at least one active substance can be released from the starting material during operation of the inhaler. In some embodiments, the moving element returns the used block to the cartridge, for example, by pushing the connecting element of the block along with the attached block of starting material back in the direction of the cartridge.

In some embodiments, the position for use includes a position in which the block is in communication with the air flow channel. In some embodiments, the position for use includes a position in which the block of the starting material can be heated to ensure vaporization of at least one active substance. Optionally, the starting material is heated by a heating element, applying an electric current to at least a part of the block of the starting material, by arranging the block inside a heating chamber and/or other. In some embodiments, the position for use includes a location inside the body of the inhaler, in which the block of the starting material is clamped in place by one or more clamping elements. Optionally, the clamping elements comprise electrical contacts, such as electrodes.

In some embodiments, pushing a subsequent block of the starting material into the position for use may occur only after the previously used block has been returned to the cartridge by the moving element and the connecting element of the block. Optionally, the moving element and the connecting element of the block remain attached to each other, provided that the cartridge remains in place relative to the inhaler. Optionally, the moving element and the connecting element of the block remain attached to each other, provided that the block of starting material is not in the cartridge.

In some embodiments, the starting material block (optionally, the last cartridge block) may remain inside the inhaler, still attached to the block connector, until the cartridge is replaced with a new cartridge. Optionally, the new cartridge comprises an empty slot for receiving the starting material block of the previous cartridge after its use. In some embodiments, the inhaler controller is programmed (in some embodiments, reprogrammed) to allow such a replacement.

In some embodiments, the cartridge comprises one or more indication pockets. In some embodiments, the indication pockets are distributed between sections, each section comprising one or more source material blocks. In some embodiments, a sequence of a plurality of source material blocks is followed by a plurality of indication pockets. Optionally, the indication pockets are arranged to separate blocks having different source material types and/or combinations thereof. Additionally or alternatively, an indication pocket located at a predetermined position within the cartridge (or a plurality of such indication pockets) can be used to indicate a specific location (for example, the indication pocket itself in the case of a single indication pocket) as a confirmation that the numbering of the pockets corresponds to the number used in the inhaler memory. Additionally or alternatively, the indication pockets can be used to indicate each source material block by its relative position relative to one or more indication pockets, so as to identify the type and/or number of the source material block, and/or whether the source material block has been used previously. Additionally or alternatively, the indicator socket can be used as a storage space, for example to insert a block of source material into a specified position after its use.

In some embodiments, the indicator receptacles comprise a block that does not comprise an electrically conductive element. Optionally, otherwise the block is identified as an indicator receptacle (e.g., by having a significantly lower or higher resistance to electrical current than the block of the original material or by resisting removal from the receptacle.

Optionally, at least some of the indication slots are empty slots. In some embodiments, the empty slots are distributed between sections, each section containing one or more blocks of starting material. In some embodiments, a sequence of a plurality of blocks of starting material is followed by a plurality of empty slots. Optionally, the empty slots are arranged to separate blocks having different types of starting materials and/or combinations thereof. Additionally or alternatively, an empty slot located in a predetermined position inside the cartridge (or a plurality of such empty slots) can be used to indicate a specific location (for example, the empty slot itself in the case of one empty slot) as a confirmation that the numbering of the slots corresponds to the number used in the memory of the inhaler. Additionally or alternatively, the empty slots can be used to indicate each block of starting material by its relative position relative to one or more empty slots, so as to identify the type and/or number of the block of starting material, and/or whether the block of starting material has been used previously. Additionally or alternatively, the empty slot can be used as storage, for example to insert a block of source material into the specified position after its use.

For example, a block of source material is pulled out of a carousel into a position for use in an inhaler. During or after use of the source material, the carousel is rotated to align the empty slot with the connector of the block, then the used block of source material can be returned to an empty slot, which is optionally different from the slot from which it was pulled out. Optionally, this process is repeated for a plurality of blocks of source material, potentially placing all used blocks in a certain area of the carousel. Optionally, the blocks of source material are used in a random order or in an otherwise selected order (i.e., different from the sequential order corresponding to the position of the blocks on the carousel), and then they can be returned to successively located empty slots.

In some embodiments, one or more indicator pockets are pre-positioned (e.g., during the manufacturing process of the cartridge) at pre-determined locations between the cartridge starting material blocks. In some embodiments, the packaged cartridge (e.g., in an airtight package) comprises a plurality of indicator pockets at pre-determined positions along the cartridge (e.g., at pre-determined positions along a carousel).

In some embodiments, the control system of the inhaler (e.g., the controller of the inhaler) "watches" for one or more indicator slots when the cartridge is initially inserted into the inhaler and/or during use of an already inserted cartridge. For example, the controller identifies the position of one or more indicator slots when the cartridge is inserted and can thereby verify that the cartridge has been placed in the correct position and/or alignment.

In some embodiments, the control system (e.g., the controller of the inhaler) is configured to identify a mismatch, i.e., an indicator slot where a block of the starting material was expected, or a block of the starting material at the location where an indicator slot was expected. When a mismatch is detected, the system can automatically fix the position, for example, by rotating the cartridge to the correct position. Alternatively, when a mismatch is detected, the system can issue a warning, which can indicate to the user the need to manually fix the position of the cartridge. Additionally or alternatively, the system otherwise warns the user about the failure of the operation.

Optionally, the indicator socket is an empty socket and identification occurs by means of a sensor (e.g. a mechanical and/or optical sensor) and/or by detecting a change in the electrical resistance of the circuit when an electrical contact is formed in the unit.

In some embodiments, the control system of the inhaler (e.g., the controller of the inhaler) is configured to identify which blocks of the starting material are currently in use, which have been used previously, which are intended for future use, or the like. Optionally, the identification occurs by means of a sensor (e.g., a mechanical and/or optical sensor) and/or by detecting a change in the electrical resistance of the circuit when an electrical contact is formed in the block. Optionally, the controller identifies one or more properties of the block of the starting material (e.g., the present or future position, content) based on a given order of the blocks in the cartridge (e.g., the order pre-programmed or hard-wired in the system). Optionally, the controller identifies one or more properties of the block of the starting material according to the current position of one or more indicator slots. Optionally, the controller identifies one or more properties of the source material block by identifying a structure that includes a source material block and an indicator slot (for example: a structure where an indicator slot is found near a plurality of source material blocks (for example, 2, 3, 4, 5 source material blocks) indicates, for example, the beginning of a sector that contains source material of a certain known type). Optionally, the indicator slots are empty slots, and the structure includes a number of empty slots and source material blocks. Optionally, the cartridge contains a computer-readable ID, for example, RFID, with encoded information about the cartridge content and/or the order of the blocks, and/or the number and/or position of the indicator slots.

In some embodiments, the subsequent block can be pulled out only after the moving element and the block connecting element are returned to the "ready to pull" position, in which at least a part of the block connecting element and, optionally, also a part of the moving element enter the cartridge body. Some potential advantages of the prepared use of the subsequent block by returning the moving element-block connecting element assembly to the "ready to pull" position may include a reduction in misuse, a reduction in the risk of damage, and protection of blocks of the original material that are not currently used inside the cartridge.

In some embodiments, the moving element-block-block connecting element assembly is arranged such that the three elements are linearly aligned with each other. For example, the cartridge is substantially rounded, and the three elements are aligned along the passage of the radial axis of the cartridge. In some embodiments, the movement of the moving element also occurs along the same rectilinear path. For example, the cartridge is substantially rectilinear, and the three elements are aligned perpendicular to the long axis of the cartridge. In some embodiments, the movement of the moving element also occurs along the same rectilinear path. A potential advantage of the arrangement in which the pulling/pushing elements and the block are linearly aligned with each other may include simplifying the mechanical operation of the assembly, reducing the risk of breakage and facilitating the detection of the current state of the assembly during operation, for example, to distinguish a full stroke of movement from an incomplete one.

Additionally or alternatively, in some embodiments, the block connector may be configured to move the blocks in a manner other than a linear push and pull, such as the block connector may be pivotable such that it pivots in and out of a plane, optionally moving the attached source material block along with it.

In some embodiments, the moving element consists of a slider that moves on a shaft, pushing the connecting element of the block (and, in turn, the block of the starting material) along with it. In some embodiments, the distal head of the slider has a shape and/or size for a fixed fit on the proximal part of the connecting element of the block. In some embodiments, the distal head of the slider has a bend and/or one or more inclined surfaces with a shape for guiding the cartridge during loading, optionally helping to bring the cartridge to the final (and, optionally, connected) position relative to the inhaler.

In some embodiments, the slider is driven by a motor-driven screw that, when rotated, moves the slider proximally or distally (depending on the direction of rotation) on the shaft. Movement of the slider on the shaft brings the attached block of source material (attached by the block connector) into position for use.

An aspect of some embodiments of the invention relates to a cartridge for use with an inhaler, wherein the cartridge is formed with an outwardly extending protrusion, located with the possibility of facilitating the alignment of the cartridge relative to said cavity in the inhaler. In some embodiments, during loading of the cartridge into the inhaler, the protrusion is installed inside said groove in the cavity of the inhaler, and when the cartridge is rotated, the protrusion is moved to an angular position, in which one or more elements inside the protrusion (for example, a connecting element of the unit) are aligned with one or more elements of the inhaler (for example, a moving element) for its engagement. Optionally, rotation of the cartridge acts on the aligned elements, which leads to locking of the cartridge relative to the inhaler.

In some embodiments, the protrusion disrupts the otherwise symmetrical cross-sectional profile of the cartridge and may therefore facilitate initial placement of the cartridge into the cavity of the inhaler and potentially reduce the time and effort required to load the cartridge for use.

In some embodiments, the connecting element of the cartridge unit extends at least partially into the bulge. Optionally, when the connecting element of the unit is moved relative to the passage of the bulge (for example, when the connecting element of the unit is pulled towards the inhaler), the passage (formed between two opposite walls of the bulge) is opened to allow the block of the starting material to be pushed (or returned) through it. In some embodiments, the passage has a width only to allow one block of the starting material to pass through it. Some potential advantages of a cartridge comprising a bulge designed so that the passage leading into and out of the cartridge has a limited size (and is at least part of the time connected by the connecting element of the unit) may include a reduced risk of contamination of the blocks of starting material inside the cartridge; a reduced amount of dust or other debris that can enter the cartridge; a reduced exposure of the starting material unit to air flow, which can cause unwanted evaporation; a reduced risk of misuse or abuse.

An aspect of some embodiments relates to a cartridge of starting material for use with an inhaler, wherein the cartridge comprises one or more safety locks that prevent the use of blocks of starting material inside the cartridge if the cartridge is not operatively attached to the inhaler. In some embodiments, the safety lock comprises a limiting frame that is aligned with a connecting element of the block in such a way as to prevent the moving of the connecting element of the block from the cartridge. In some embodiments, when the cartridge is positioned in said cavity and/or when the cartridge is oriented relative to the cavity (e.g., rotated), the limiting frame is moved with a different alignment relative to the connecting element of the block, ensuring that the connecting element of the block passes through it. Another safety lock may comprise a limiter that, in an active state, prevents internal movement of blocks of starting material in the cartridge, for example, by preventing internal rotation of the blocks, impeding the movement. Optionally, the limiter is released during the positioning of the cartridge in the cavity of the inhaler, for example, by closing the door of the lid above the cartridge.

An aspect of some embodiments relates to a cartridge of starting material for use with an inhaler, wherein the cartridge is configured to indicate, for example by means of structural changes in the cartridge, that all of the starting material blocks in the inhaler have been used. Optionally, the last 10%, the last 20%, the last 5% of the cartridge blocks or the last block or two comprise an indicator indicating that the cartridge has been completely used. In some embodiments, the indicator is a structural change in the starting material block, the cartridge body and/or the slot in which the starting material block is located. Examples of structural changes include starting material blocks that are located in slots of a carousel, wherein the last slot (or several slots) on the carousel remain empty (do not contain a starting material block). In another example, the structural change includes a cartridge (located last or in a predetermined location relative to the last slot), which does not contain starting material, for example, contains only a block frame. In another example, the structural change includes a cartridge that does not contain an electrically conductive element. In some embodiments, the structural change does not include either an electrically conductive element or a starting material. In some embodiments, in the same cartridge, for example, in the last 2 or 3 cavities, two or more different or identical structural changes are used. Optionally, the structural changes mechanically and/or electrically affect the process of pushing and/or otherwise using the starting material block.

An aspect of some embodiments relates to a rotary cartridge of the raw material, the rotation of which is limited to prevent access to blocks of the cartridge of the raw material that have already been used. In some embodiments, the rotation is limited to 360 degrees, 180 degrees, 90 degrees, or intermediate greater or lesser angles. The cartridge can be rotated clockwise and/or counterclockwise.

An aspect of some embodiments relates to a cartridge of starting material for use with an inhaler, wherein the cartridge comprises an identification tag, such as an RFID tag, which can be read and written. In some embodiments, information recorded on the RFID tag identifies permission to use the cartridge with the inhaler. In some embodiments, the RFID tag comprises data regarding the previous use of starting material from the cartridge, such as: the number of blocks of starting material that were used, the specific blocks of starting material that were used, the type of starting material used, the date or time when the last block of starting material was used and/or other relevant usage data.

In some embodiments, the inhaler is configured to detect and/or track the progress of the cartridge usage. In some embodiments, the controller of the inhaler is programmed to count or index the number of used blocks of the starting material and/or the number of blocks of the starting material still available for use. Additionally or alternatively, the internal memory tracks the blocks. Additionally or alternatively, the inhaler (e.g., via the controller) communicates with an external memory or database, such as a cloud memory, to track the usage of the cartridge.

In some embodiments, the blocks of the starting material and/or the cartridge slots in which they are located contain an identification marking. Optionally, data indicating the identification marking can be obtained using an RFID tag associated with the cartridge.

An aspect of some embodiments relates to a kit comprising an inhaler and a cartridge of starting material for use with the inhaler, wherein the cartridge comprises an identification tag, such as an RFID tag, which can be read and/or written by the inhaler. In some embodiments, according to information on the RFID tag, the inhaler identifies that the correct cartridge has been inserted for use. In some embodiments, the inhaler is configured to record data in the RFID tag corresponding to the use of the starting material from the cartridge, such as: the number of blocks of starting material that have been used, the specific blocks of starting material that have been used, the type of starting material used, the date or time when the last block of starting material was used, and/or other relevant data on use.

In the context of the present invention, an "indicator", "indication slot", "indication unit" may comprise one or more of: an empty slot (a slot that does not contain the starting material or the space formed between an adjacent block of the starting material); a block that contains a different design and/or shape, for example, a block that does not contain an electrically conductive element; a block that has a shape that differs from at least 55%, at least 70%, at least 85%, or an intermediate greater or lesser percentage of the total number of blocks in the cartridge; a block that has a shape that differs from the majority of the starting material blocks in the cartridge; a block that has a design that differs from the "standard" starting material blocks pushed for use in the cartridge. The "indicator", "indication slot", "indication unit" may or may not be filled with the starting material.

In some embodiments, the "indicator", "indication socket", "indication unit" may be identified by a sensor. Optionally, the sensor is a mechanical sensor. Optionally, the sensor is an electrical sensor, such as a sensor, which detects another electrical resistance or does not detect it when in contact with the indicator. Optionally, the sensor is an optical sensor, such as a light sensor, which detects another color of the indicator, the absence of color (for example, when using an empty socket) and / or other.

Additionally or alternatively, the "indicator", "indication socket", "indication unit" may be recognized by the system controller, for example, based on a predetermined position of the indicator. Optionally, the predetermined positions of the indicators in the cartridge are encoded in the cartridge itself (e.g., on an RFID tag) and/or otherwise programmed in the system.

Before explaining in detail at least one embodiment of the invention, it should be understood that the application of the invention is not necessarily limited to the details of the design and arrangement of components and/or methods set forth in the following description and/or shown in the figures and/or in the examples. Other embodiments or practical application or implementation of the invention in various ways are possible.

Now with reference to the figures in Fig. 1 there is shown a block diagram of a system comprising an inhaler 101 adapted to receive and/or otherwise attach to a cartridge 103 comprising a plurality of blocks 105 of starting material. The inhaler 101 is shown with a cartridge 103. In some embodiments, the cartridge 103 comprises a block connector 107 adapted to connect between a block 105 of starting material within the cartridge and a moving element 109 of the inhaler.

During operation, according to some embodiments, the moving element 109 engages the connecting element 107 of the block to pull, move or otherwise activate the movement of the block 105 into a position for use inside the inhaler device. In some embodiments, at least one active substance is released from the block 105 by the release mechanism 113. In some embodiments, the release mechanism includes placing the block in communication with the air flow path, for example, so that the air flow can pass into and through the starting material in the block. In some embodiments, the release mechanism includes engaging the block with electrical contacts (for example, electrodes) to initiate heating of the starting material. Optionally, the block is moved to a position in which it is clamped inside the air flow path of the inhaler while the starting material contained inside it is heated for vaporization.

In some embodiments, after the block 105 is used, the block is returned to the cartridge by the assembly of the block coupling element and the moving element. Optionally, the block coupling element and the moving element remain attached to each other during the start of the mechanism for advancing blocks in the cartridge (manually and/or automatically), moving the block of the starting material (optionally, the subsequent one) to a position in which it engages the block coupling element 107. In some embodiments, the subsequent block can be engaged by the block coupling element only when the block coupling element has at least partially returned to the cartridge (for example, has at least partially returned to the cartridge housing). In some embodiments, the block coupling element returns to the cartridge to such an extent that defines the relative position of the returned block. For example, the block coupling element reaches a "full stop" when the block of the starting material has advanced into the cartridge to a predetermined limit, for example, until it collides with the inner wall of the cartridge housing. Optionally, during the return, the block coupling element is completely inserted inside the cartridge housing. In some embodiments, the block connector and the moving element remain attached to each other for the condition that the cartridge is operatively connected to the inhaler. In some embodiments, when the cartridge is removed (e.g., when all the blocks of the starting material have been completely used up), the moving element is disconnected from the block connector, and the cartridge can be removed or replaced with a new cartridge. A potential advantage of ensuring that the blocks of the starting material are used only when the moving element of the inhaler is connected to the block connector of the cartridge may include a reduction in the risk of unwanted use and/or abuse, for example, by preventing the possibility of manually selecting a block (e.g., from a broken cartridge) and placing it for use in the inhaler. Another potential advantage may include providing a visual distinction between different cartridges, for example, cartridges containing different starting materials, for example, by means of block connectors that are colored differently.

In some embodiments, the block connecting element 107 has a shape and/or size and/or is positioned such that it forms a protrusion 111 on the outer body of the cartridge 103. In the example shown in this document, the cartridge body is substantially rounded (e.g., with a disk shape), and the block connecting element extends radially outward from the perimeter, forming a protrusion relative to the rounded body.

In some embodiments, the protrusion 111 formed by the connecting element 107 of the block facilitates the alignment of the cartridge when attached to the inhaler, it projects relative to the cartridge for engagement with the moving element of the inhaler.

In some embodiments, the arrangement of the block connector 107 (at least partially) in the cartridge opening through which the blocks of the source material pass reduces the amount of air flow, dust, debris and/or other contamination that may enter the cartridge, thereby protecting the blocks of the source material from damage. Additionally or alternatively, the arrangement of the block connector 107 (at least partially) in the cartridge opening may reduce or prevent air movement along the block of the source material, thereby reducing evaporation and loss of volatiles from the source material.

Some embodiments may include a mechanism for breaking the block connector or otherwise limiting the function of the block connector, such as after the last block of starting material in the cartridge has been used to prevent or hinder future use of an empty cartridge,

In some embodiments, the cartridge 103 comprises a plurality of blocks of the starting material, such as 5, 10, 50, 60, 75, 70, 100, 200 or an intermediate greater or lesser number of blocks of the starting material. Optionally, the blocks are arranged sequentially. In some embodiments, the blocks are aligned along a carousel or a disk-shaped structure and rotated so that at each rotation another block engages the connecting element of the block. Alternative designs may comprise a rectilinear cartridge in which the blocks are stacked on top of each other or aligned with each other.

In some embodiments, block 105 comprises one or more starting materials from which one or more active substances are released by heating the starting material. In some embodiments, the starting material comprises a plant substance. In some embodiments, the material comprises at least one plant substance selected from the group consisting of: Cannabis sativa, Cannabis indica, Cannabis ruderalis, Acacia spp., Amanita muscaria, Yage, Atropa belladonna, Areca catechu, Brugmansia spp., Brunfelsia latifolia, Desmanthus illinoensis, Banisteriopsis caapi, Trichocereus spp., Theobroma cacao, Capsicum spp., Cestrum spp., Erythroxylum coca, Solenostemon scutellarioides, Arundo donax, Coffea arabica, Datura spp., Desfontainia spp., Diplopterys cabrerana, Ephedra sinica, Claviceps purpurea, Paullinia cupana, Argyreia nervosa, Hyoscyamus niger, Tabernanthe iboga, Lagochilus inebriens, Justicia pectoralis, Sceletium tortuosum, Piper methysticum, Catha edulis, Mitragyna speciosa, Leonotis leonurus, Nymphaea spp., Nelumbo spp., Sophora secundiflora, Mucuna pruriens, Mandragora officinarum, Mimosa tenuiflora, Ipomoea violacea, Psilocybe spp., Panaeolus spp., Myristica fragrans, Turbina corymbosa, Passiflora incarnata, Lophophora williamsii, Phalaris spp., Duboisia hopwoodii, Papaver somniferum, Psychotria viridis, spp., Salvia divinorum, Combretum quadrangulare, Trichocereus pachanoi, Heimia salicifolia, Stipa robusta, Solandra spp., Hypericum perforatum, Peganum harmala, Tabernaemontana spp., Camellia sinensis, Nicotiana tabacum, Nicotiana rustica, Virola theidora, Voacanga africana, Lactuca virosa, Artemisia absinthium, Ilex paraguariensis, Anadenanthera spp., Corynanthe yohimbe, Calea zacatechichi, Coffea spp.(Rubiaceae), Sapindaceae spp., Camellia spp., Malvaceae spp., Aquifoliaceae spp., Hoodia spp. Chamomilla recutita, Passiflora incarnate, Camellia sinensis, Mentha piperita, Mentha spicata, Rubus idaeus, Eucalyptus globulus, Lavandula officinalis, Thymus vulgaris, Melissa officinalis, Tobacco, Aloe Vera, Angelica, Anise, Ayahuasca (Banisteriopsis caapi), Barberry, Black Horehound, Blue Lotus, Burdock, Camomille/Chamomile, Caraway, Cat's Claw, Clove, Comfrey, Corn Silk, Couch Grass, Damiana, Damiana, Dandelion, Ephedra, Eucalyptus, Evening Primrose, Fennel, Feverfew, Fringe Tree, Garlic, Ginger, Ginkgo, Ginseng, Goldenrod, Goldenseal, Gotu Kola, Green Tea, Guarana, Hawthorn, Hops, Horsetail, Hyssop, Kola Nut, Kratom, Lavender, Lemon Balm, Licorice, Lion's Tail (Wild Dagga), Maca Root, Marshmallow, Meadowsweet, Milk Thistle, Motherwort, Passion Flower, Passionflower, Peppermint, Prickly Poppy, Purslane, Raspberry Leaf, Red Poppy, Sage, Saw Palmetto, Sida Cordifolia, Sinicuichi (Mayan Sun Opener), Spearmint, Sweet Flag, Syrian Rue (Peganum harmala), Thyme, Turmeric, Valerian, Wild Yam, Wormwood, Yarrow, Yerba Mateu Yohimbe and any part or combination thereof.

Examples of active substances released from the starting material may include, but are not limited to: Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerodes (CBG), cannabichromenes (CBC), cannabinol (CBN), cannabinodiol (CBDL), cannabicyclol (CBL), cannabilsoin (CBE), cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), and cannabitriol (CBT) and/or the corresponding cannabinoid acids that form such active substances upon decarboxylation.

In some embodiments, the block 105 comprises a material (e.g., a plant substance) carrying at least one active substance, and optionally comprises additional elements for transporting, mechanically stabilizing and/or volatilizing or evaporating (e.g., by heating) the active substance. In some embodiments, the block comprises a material with an active substance for delivery to the user for inhalation during a selected number of inhalations using an inhaler, such as during no more than 1, 2, 3, 4, 7, 10 inhalations or an intermediate greater or lesser number. In some embodiments, the block 105 comprises a single dose of a medicinal substance for delivery to the lungs of a patient using an inhaler.

In some embodiments, the starting material is located inside the starting material block 105 in a flattened shape. Optionally, the starting material is located such that air can be drawn or otherwise passed through the material to extract the active substance. In some embodiments, the material is located in the form of a tray containing, for example, a porous or fibrous material with a flat arrangement, thin enough to allow air flow to pass through and between the two largest surfaces.

For example, the block comprises a tray of feedstock held between opposing mesh structures. Feedstock blocks described in U.S. Patent No. 9,802,011, assigned to the present document, which is incorporated herein by reference, are also contemplated in this application, (See, reference to "single dose cartridge" as equivalent to a feedstock block).

Fig. 2 is a block diagram of a general method of using an inhaler configured to be operatively connected to a cartridge comprising a plurality of source material blocks and a block connecting element according to some embodiments.

In some embodiments, a cartridge comprising a plurality of blocks of the starting material and a block connecting element is loaded into the inhaler (201). Optionally, the cartridge extends into said opening, cavity or recess in the inhaler body. Alternatively, the cartridge is operatively attached to the inhaler body so that at least the block connecting element is accessible to one or more elements of the inhaler, such as a moving element.

In some embodiments, loading the cartridge (and/or inserting or otherwise attaching) simultaneously causes the movement of the inhaler moving element, which engages the block connecting element in the cartridge. The block connecting element, in turn, is already connected to the raw material block in the cartridge (e.g., connected to the first block in a row), and the moving element-block connecting element-block assembly is moved to a position ready for pulling. In some embodiments, the cartridge is placed in place by a locking mechanism, which then triggers the attachment of the inhaler moving element to the cartridge block connecting element. A potential advantage of loading the cartridge, which automatically triggers the engagement of the raw material block so that it is ready for use, may include saving time and effort for the user of the inhaler.

In some embodiments, the inhaler is activated for using a block of raw material, wherein the block is accessible via a connecting element (203) of the block, optionally only via the connecting element of the block. Optionally, the block is drawn into the body of the inhaler using the moving element-connecting element assembly of the block. In some embodiments, the blocks of raw material cannot be accessed for their commissioning (e.g. for pushing) without engaging with the connecting element of the block. This can prevent unwanted use, limit excessive use and ensure that the cartridge can only be used with said inhaler. Optionally, the connecting element of the block is designed such that it is configured to be attached, locked or otherwise connected only to the corresponding moving element of the inhaler.

In some embodiments, optionally, after the first block of the starting material is used, the advancement of the cartridge is initiated to allow the use of the second block (205) of the starting material. In some embodiments, the second block is accessible only when the connecting element of the block or at least a part of the connecting element of the block has returned to the cartridge, for example, to the lumen formed by the cartridge body. Optionally, the used block of the starting material is returned to the initial position in the cartridge. Alternatively, the used block of the starting material is returned to another slot in the same cartridge or to another cartridge. In some embodiments, the advancement of the cartridge moves the second block into contact with the connecting element of the block. Optionally, the moving element remains attached to the connecting element of the block, so that after the insertion of the moving element-connecting element of the block-block, the second block can be moved (for example, retracted) for use.

In some embodiments, the advancement of the cartridge is performed by internal movement of blocks of the source material in the cartridge, such as rotation. In some embodiments, one or more blocks are skipped (jumped) during the advancement of the cartridge to reach a block of the source material other than the subsequent block. In some embodiments, the rotation and/or jumping can be performed in one or more directions to select specific blocks of the source material based on, for example, their content and/or their previous use.

In some embodiments, the rotation of the raw material blocks in the cartridge and/or the rotation of the cartridge as a whole (e.g., including the cartridge housing) is initiated by one or more gears. For example, one or more rotating gears are configured inside the inhaler housing in a position suitable for engaging the cartridge when inserted into the cavity.

In some embodiments, the advancement of the cartridge is controlled by a controller of the inhaler. Optionally, the advancement of the cartridge is controlled according to the content of the blocks of the starting material in the cartridge and/or their previous use, for example, the controller is programmed to start the advancement in such a way as to skip one or more blocks and, optionally, not to use the blocks more than once. In some embodiments, the blocks in the cartridge may contain different starting materials and/or different concentrations of active substances and/or different amounts of starting material. Optionally, the controller controls the advancement of the blocks in the cartridge according to a predetermined mode selected for the user. Optionally, the controller selects the used block for use according to the amount of active material remaining in the block and/or the amount already extracted from it.

Fig. 3 is a cross-sectional view of a mechanism for engaging a block of source material contained in a cartridge to move the block into a position for use according to some embodiments.

In some embodiments, the block connecting element 301 is installed between the block 303 of the starting material and the moving element, in this example in the form of a retractable slider 305. In some embodiments, the block connecting element comprises a distal portion 307 with a shape and/or a size for engaging the block 303 and a proximal portion 309 with a shape and/or a size for engaging the slider 305. Optionally, the block connecting element and the block are connected by means of geometric parts that interact with each other, for example, by having a recess formed in one of the elements and, respectively, a molded projection on the other element. Optionally, the block connecting element and the slider are connected by means of geometric parts that interact with each other, for example, by having a recess formed in one of the elements and, respectively, a molded projection on the other element.

In some embodiments, as can be seen, for example, in the detailed view of Fig. 4A, the distal part 307 of the block connecting element is located inside the connecting part of the block 303, in this example with a shape in the form of jaws with a latch. The proximal part 309 of the block connecting element is mounted on the distal head 311 of the slider 305. In this example, the proximal part 309 of the block connecting element has a shape in the form of a frame with a rectangular cross-section, having an opening 325, into which the distal head 311 of the slider passes with the possibility of sliding. In some embodiments, the distal head 311 is substantially T-shaped. In some embodiments, the opening 325 has a shape and size for receiving the T-shaped head of the slider. A potential advantage of the T-shaped head may include obtaining strong clamps on the block connecting element, facilitating its pushing and/or pulling.

In some embodiments, for example shown in Fig. 4B, the distal head 311 of the slider comprises one or more inclined surfaces. In some embodiments, the distal head 311 comprises a main inclined surface 313, which is inclined to facilitate the insertion of the cartridge, providing at least some degree of movement, while positioning the cartridge relative to the inhaler. In some embodiments, the inclined surface 313 helps to guide the cartridge to the final position relative to the cavity of the inhaler in which it fits. Optionally, the distal head 311 of the slider is formed with a bend, which is selected to reduce interference when inserting the cartridge. In some embodiments, the distal head 311 comprises one or more small inclined surfaces 315, which are inclined to facilitate the installation of the coupling element 301 of the block on the distal head 311 of the slider when rotating the cartridge relative to the inhaler, for example to guide the cartridge to the attached position.

Returning to Fig. 3, in some embodiments, the movement of the slider 305 is initiated by a shaft and screw assembly. During operation, the screw 319 rotates (e.g., from a motor, a set of gears, and/or other electromechanical or purely mechanical actuator), causing the housing 321 of the slider 305 to move in a proximal direction or in a distal direction (depending on the direction of rotation) on the shaft 323. When the slider moves distally or proximally on the shaft, it carries with it a block coupling element 301, which in turn carries a block 303 of the starting material.

In some embodiments, the housing 321 of the slider 305 comprises a groove 327 (see Fig. 4C) through which the shaft 323 passes. Optionally, the groove prevents rotation of the slider when moving distally or proximally, such as when rotating about its long axis.

It should be noted that the mechanism for moving the block described above, for example, is presented and that other mechanisms can be used, for example: a pulley, a magnetic actuation, manual movement of a slider, a spring actuation and/or other mechanisms designed to move the block of starting material from the cartridge to a position in which at least one active substance can be released from the starting material contained within the block.

In some embodiments, the block connector 301 is formed with one or more recesses 329. Optionally, the bounding frame (shown partially at 331) is shaped to fit within the recesses 329 to prevent movement of the block connector (e.g., prior to operative attachment of the cartridge to the inhaler).

Fig. 5A-B show a cross-sectional view of a mechanism, for example, shown in Fig. 3, and an isometric view of a block connector according to some embodiments. Fig. 5A further shows a cartridge housing 501 when the cartridge is installed in said cavity (not shown in this figure) of the inhaler. As can be seen, in some embodiments, the block connector 301 extends from the inside of the housing 501 in a proximal direction, wherein at least a part of the block connector is located outside the perimeter formed by the housing (in this example, a rounded perimeter). Optionally, at least a part of the block connector is located inside the bulge of the cartridge.

As can be seen further, in some embodiments at least a portion of the slider 305, such as the distal head 311, enters the cartridge bulge when engaged with the connecting element 301 of the block. Optionally, the movement of the slider 305 (or any moving element in general) is limited, and/or it is short enough that it does not extend into the cartridge at all or does not extend further than the clearance of the bulge. A potential advantage of limiting the extent of reaching the moving element may include a reduced risk of mechanical damage, a reduced risk of contamination within the cartridge and/or a reduced risk of misuse.

Fig. 5B further shows a block connecting element 301 attached to the source material block 303.

Fig. 6A1-B3 show a side view (6A1, 6A2, 6A3) and an isometric view (6B1, 6B2, 6B3)) of the process of placing and, optionally, locking a cartridge containing a block connector in position relative to the inhaler according to some embodiments.

In some embodiments, the cartridge is located inside said cavity or recess formed in the inhaler. Optionally, the cartridge is moved to the attached position relative to the inhaler. In some embodiments, the cartridge is locked by rotation, linear movement, pushing downwards, by sliding and/or by magnetic attraction.

In the example shown in this document (see 6A1 and 6B1), the carousel-type cartridge 601 is initially positioned relative to the inhaler such that the bulge 603 of the cartridge (into which the connecting element 605 of the block extends from the inside) is positioned adjacent to, but not yet in contact with, the retractable slider 607. Optionally, the distal head 609 is aligned with the opening 619 of the connecting element of the block along the perimeter of the cartridge housing.

In some embodiments, by setting the angular position of the cartridge, for example, by rotating the cartridge clockwise, as shown in Fig. 6A2 and 6B2, the block coupling element 605 is advanced into a position in which it is connected to the slider 607. In the example shown in this document, the distal head 609 of the slider extends inside the corresponding geometry of the block coupling element, for example, inside the frame 613.

In some embodiments, the movement (e.g., rotation, lifting, lateral movement) of the cartridge relative to the inhaler is limited. For example, the rotation of the cartridge can be stopped by the wall 621 of the convexity 603 when colliding with the distal head 609 of the slider. Additionally or alternatively, the rotation of the cartridge is determined by the curvature of the recess or cavity of the inhaler in which the cartridge is installed, and/or by a snap-in connection mechanism.

In some embodiments, in the final position shown, for example, in Fig. 6A3 and 6B3, the cartridge is connected to the inhaler, and the slider, the block connecting element and one of the blocks 615 of the starting material are linearly aligned with each other, for example along the radial axis 617 of the cartridge.

In some embodiments, the block connector and the slider remain connected to each other during a break in use of the cartridge, and are disconnected when the cartridge is removed from the inhaler (e.g., by turning the cartridge in the opposite direction).

In some embodiments, the carousel of cartridge source material blocks is configured to rotate clockwise and/or counterclockwise to advance from one block to another. In some embodiments, source material blocks are pulled for sequential use. Alternatively, source material blocks are pulled for use in a different order.

In some embodiments, the rotation of the cartridge (clockwise or counterclockwise) is limited. In some embodiments, the rotation of the cartridge is limited to the extent set by the first block of the cartridge's starting material, in order to limit the rotation passing the location of the first block. In some embodiments, the rotation of the cartridge in each direction is limited to a maximum of 360 degrees. In other embodiments, the rotation of the cartridge may be limited to 180 degrees, 90 degrees, or an intermediate greater or lesser rotation angle. A potential advantage of limiting the rotation of the cartridge to a full circle, but no more, may include preventing accidental access to blocks of starting material that have already been used.

Fig. 7A-C illustrate a method for removing a block of source material from a cartridge according to some embodiments.

In Fig. 7A, the slider 701 is in the most distal position relative to the shaft 703, while the distal head 705 (see 7B) of the slider engages the block coupling 707 (see 7B) inside the bulge 709 of the cartridge 711. In Fig. 7B, the slider 701 is in a middle position relative to the shaft 703, pushing along with it the block coupling 707, as well as the block 721 of the starting material, which is connected to the block coupling and is withdrawn from the cartridge. In some embodiments, as shown in this example, the movement of the slider is initiated by turning the screw 713 (see also Fig. 3). In Fig. 7C, the block 721 has completely exited the cartridge, and the slider 701 is in the most proximal position relative to the shaft 703.

In some embodiments, a passage 715 is formed between the opposite walls 717 of the protuberance 709. Optionally, the passage 715 is wide enough to allow the block 721 of the starting material to slide through it. In some embodiments, the dimensions (e.g., the width) of the passage 715 are selected according to the thickness of the block 721, for example, so as to allow only one block to pass through it at a time. Some potential advantages of a restricted passage may include a reduced risk of malfunctions (e.g., unwanted pushing of more than one block); reduced exposure of the cartridge contents to external conditions, such as humidity; reduced exposure of the cartridge contents to contamination and debris; and alignment of the block of starting material relative to said seat in the inhaler and/or in the cartridge, so that the block can be easily pulled or pushed into said seat. In some embodiments, the opposite walls of the protuberance are shaped so as to allow the passage of a T-shaped element, such as a T-shaped distal head of the moving element.

Fig. 8A-B illustrates a cartridge comprising a protrusion (8A) and a detailed view of the protrusion showing a block coupling (8B) according to some embodiments. In some embodiments, the cartridge 801 comprises a protrusion 803 protruding from the outer surface of the cartridge. Optionally, at least a portion of the block coupling 805 located inside the cartridge extends inside the protrusion (see the enlarged view of Fig. 8B). In some embodiments, the block coupling 805 is formed with tail projections 825 on its proximal surface. Optionally, when the cartridge is in the cavity of the inhaler and then rotated to the final position for use, the tail projections 825 slide inside corresponding grooves formed in the walls of the cavity of the inhaler, guiding the cartridge to the final position.

In some embodiments, the protrusion 803 is located, has a shape and/or size to facilitate the alignment of the cartridge relative to the said recess of the inhaler device (not shown here). Optionally, the protrusion 803 extends at a distance 811 between 1, 3, 5, 10, 20 mm or intermediate, longer or shorter distances relative to the outer perimeter of the cartridge body. Optionally, the protrusion 803 extends at a radial distance 813 between 5, 10, 20, 50, 80 mm or intermediate, longer or shorter distances from the center of the cartridge.

In some embodiments, the cartridge 801 comprises a window 807 for indicating the progress of use, for example, showing the number of the raw material block that is currently connected to the block connector. In some embodiments, the cartridge 801 is formed with a central opening 809. Optionally, during insertion, the opening 809 is screwed onto a pin or other structure (not shown in this figure) suitable for screwing the opening onto it, to facilitate placement of the cartridge. In some embodiments, for example, when closing the door of the inhaler lid (not shown in this document) after the cartridge is in place, the pin engages or otherwise activates a rotation trigger mechanism that determines an internal rotation of the raw material blocks in the cartridge, optionally placing another block in contact with the block connector at each rotation.

In some embodiments, the cartridge is substantially rounded, but not circular. In this example, the cartridge 801 comprises a first portion 817 having a first radius and a second portion 819 having a different radius. A potential advantage of a cartridge comprising an asymmetric profile may include facilitating alignment of the cartridge relative to the cavity of the inhaler during insertion.

In some embodiments, the cartridge comprises an identification tag, such as an RFID tag. In some embodiments, the identification tag comprises data relating to the cartridge, such as: the number of starting material blocks in the cartridge; the type(s) of starting material; the types of active agent(s); the amount of active agent; which starting material(s) are contained in each starting material block (if, for example, different blocks in the cartridge contain different starting materials); the location of each starting material block within the cartridge; the date of manufacture; the expiration date; lot information, usage information, and/or data relating to another cartridge. In some embodiments, the inhaler comprises or is associated with an RFID reader/writer. In some embodiments, the RFID reader/writer identifies the cartridge when it is loaded. In some embodiments, the RFID reader/writer is programmed to write data to the tag of the cartridge, such as: the number of starting material blocks that have been used from the cartridge; the numbering and/or location of the used blocks of starting material (in one example, the blocks are sequentially numbered according to their respective location in the cartridge, but they can be used in any order); the amount of active substance that has been extracted and/or remains in each used block; and/or data regarding the use of a different cartridge.

Fig. 9A-B are illustrations of an inhaler comprising a cartridge, such as that shown in Fig. 8A-B, in an initial insertion position (Fig. 9A) and in a final (optionally attached) position (Fig. 9B), according to some embodiments.

In some embodiments, the inhaler 901 comprises a cavity 903 for receiving a cartridge, such as the cartridge 801 shown in Fig. 8A-B. In some embodiments, the inhaler comprises a lid door 905 that can be opened and closed to insert or remove the cartridge. In some embodiments, the lid door 905 is shaped to slightly move the cartridge, such as pushing it during closing to the final position relative to the inhaler cavity. Optionally, the lid door comprises a lock that prevents the lid door from opening if the connecting element of the unit has not returned to its most distal position.

Fig. 9A shows the cartridge installed within the cavity during initial insertion. Optionally, in this position the blocks of the starting material within the cartridge cannot be accessed for use. In Fig. 9B the cartridge is rotated into the connected position relative to the inhaler, thereby aligning the connecting element of the block, the slider and one of the blocks of the starting material relative to each other. The aligned elements ensure that the block is pulled into the inhaler to release at least one active substance from the starting material and deliver it for inhalation by the user; and/or pushing the used block back into the cartridge.

(It should be noted that the inhaler mouthpiece is not shown in this figure.)

Fig. 10A-C show different views of the cavity of the inhaler, in which the cartridge of the starting material is inserted according to some embodiments. In some embodiments, the cavity 1001 has a bend that corresponds to the bend of the cartridge. Optionally, the bend is asymmetrical. The asymmetrical bend can help to orient the cartridge relative to the cavity. Alternatively, the bend is symmetrical.

In some embodiments, the cavity 1001 comprises a recess 1003 in which the protrusion of the cartridge is located. In some embodiments (see the detailed view of Fig. 10B), the distal head 1005 of the moving element of the inhaler projects into the space of the cavity near the recess. Optionally, the distal head 1005 is positioned such that when the cartridge is first installed in the cavity 1001, engagement with the distal head 1005 is not carried out; after rotation of the cartridge (in this example, approximately 1-10-20-45-90 degrees clockwise), the distal head slidably enters inside the corresponding geometry of the coupling element of the cartridge unit. In some embodiments, the distal head 1005 is positioned relative to the housing of the cartridge such that even rotation of the cartridge in the cavity of the inhaler does not break or otherwise damage the distal head. Optionally, when the cartridge is initially placed in the cavity, the distal head only lightly contacts the cartridge housing; then, when the cartridge is rotated to its final position, the block coupling element rotates with it until it receives the distal head of the slider. A potential advantage of this design is that even in the most distal position of the slider, in which it extends outward from the inhaler housing to reach the cartridge, there is no risk of breakage and/or other deformation that may occur during cartridge loading (especially when the cartridge is manually loaded by the user, which is more difficult to control).

In some embodiments, the cavity 1001 comprises a central protruding element 1007, such as a pin or thread, onto which a corresponding opening of the cartridge can be placed. Optionally, the central protruding element comprises ribs 1015 for activating the internal rotation of the raw material blocks in the cartridge after the cartridge is installed in the cavity of the inhaler.

In some embodiments, the cavity 1001 comprises a bump 1009, optionally located on the side wall of the cavity. In some embodiments, when the cartridge is rotated from its initial position in the cavity to the final orientation in which the cartridge is operatively attached to the inhaler, the bump 1009 contacts the cartridge body and creates a "clicking" sound, indicating to the user that the cartridge has reached its final position and no further rotation is required.

Fig. 11A-B illustrates a limiting frame and a cartridge movement limiter in an attached position (11A) and a released position (11B) according to some embodiments.

In some embodiments, the cartridge comprises a limiting frame 1101 that is mechanically transformable from an attached position in which the block coupling element 1103 is prevented from moving, to a released position in which the block coupling element can move along the extension of a radial axis to be pulled (or pushed back) into the cartridge.

In some embodiments, the confining frame is released gradually. Optionally, different frame locks are initiated to release at different stages of the cartridge loading process.

For example, compression of the spring 1105, for example, when placing the cartridge in the cavities of the inhaler, releases the frame portion 1107, causing it to spring upward, thereby releasing the frame portion 1109 (which was clamped in place by the finger 1111 of the portion 1107). Optionally, when releasing the portion 1109, the portion 1109 is freed to slide sideways so that the opening 1113 formed in the portion 1109 is aligned with the connecting element 1103 of the block. The opening 1113 is shaped so that the connecting element of the block can be pulled or pushed through it.

In some embodiments, the cartridge comprises a limiter that limits the internal movement (e.g., rotation) of the starting material blocks. In some embodiments, the limiter is released by closing the doors of the inhaler lid over the cartridge. For example, compression of the spring 1115 (e.g., by closing the door of the lid, not shown in this document) releases the pivot door 1117. In some embodiments, the pivot door 1117 is connected to a locking element, such as teeth 1119 (see Fig. 11C), so that when the door is released, the teeth 1119 move from a position in which they interfere with the rotation of the starting material blocks (e.g., due to placement between the blocks), to a pivot position in which they are aligned with a geometric gap 1121 between the blocks, allowing the rotation of the blocks passing the teeth. Additionally or alternatively, a control component, such as a microswitch (not shown), is integrated into the closing mechanism (e.g., onto the lid door of the inhaler and/or into associated parts of the inhaler housing that contact the lid door) and is configured to electronically lock the inhaler device after the lid door is in the open position.

In some embodiments, during the use of the raw material block, for example, during the period of time between pulling the block into the position for use and returning it to the cartridge, the lid door of the inhaler remains connected, for example, to prevent the cartridge from being removed during use. In some embodiments, the sensor component indicates that the block has been pulled out for use and/or that the block is currently in the position of use inside the inhaler, and/or that the block has been returned to the cartridge, for example after use. Optionally, based on the indication received from the sensor component, the lid door locking mechanism is activated. For example, if the sensor component indicates that the raw material block has been pulled in for use, the lid door is locked, thereby preventing the cartridge from being removed during use.

In some embodiments, the sensor component comprises a sensor, such as a pressure sensor, an optical sensor (light sensor) and/or another sensor, configured to detect whether the block of the starting material is removed from the cartridge and/or to detect whether the block of the starting material is currently placed in the use position. In some embodiments, the sensor component comprises a mechanical element, such as a latch.

In some embodiments, the sensor component is configured in the cartridge itself. Additionally or alternatively, the sensor component is configured in the inhaler, such as in a cavity in which the cartridge is received.

In some embodiments, after the starting material block is removed from the cartridge (e.g., retracted into the use position), the inhaler lid door is mechanically and/or electronically locked, optionally until the starting material block is returned.

Fig. 12 is a flow chart of a method for loading a cartridge, in which the locking mechanisms of the cartridge are simultaneously released according to some embodiments. In some embodiments, the cartridge is located in said cavity of the inhaler (1201). Optionally, the initial placement initiates the release or partial release of the locking mechanism, for example, by compressing a spring-actuated mechanism. In some embodiments, the cartridge is rotated to a final (optionally connected) position relative to the inhaler (1203). Optionally, the rotation releases a limiter of the block coupling element (such as the limiting frame described above) to allow movement of the block coupling element, for example, by allowing the block coupling element to be pulled in or pushed out by the moving element of the inhaler. In some embodiments, closing the door of the lid of the inhaler over the loaded cartridge (1205) to allow the advancement of the blocks releases a limiter that prevents movement of the raw material blocks (for example, internal rotation in the cartridge housing).

Fig. 13 is a flow chart of a method for identifying a fully used cartridge according to some embodiments.

In some embodiments, a cartridge containing a plurality of blocks of starting material is loaded into the inhaler (1301). The inhaler is then activated to use the blocks (1303) of starting material, for example, as described above. In some embodiments, the activation of the inhaler is repeated until the inhaler identifies that the last block of starting material in the cartridge has been used, optionally based on a block count and/or structural changes in the cartridge (1305).

In some embodiments, the identification that the cartridge now does not contain the starting material is carried out based on structural changes in the cartridge. For example, the cartridge comprises a carousel of starting material blocks, and the last slot of the carousel remains empty. In another example, the cartridge comprises a carousel of starting material blocks, and the last block on the carousel is a block that does not contain the starting material, i.e. only a frame of the block (not containing a grid through which a current is supplied to heat the starting material). In the first example, the controller of the inhaler is configured to identify an empty slot when, upon activation, the connecting element of the cartridge block is pulled out without being attached to any block, providing direct contact of the electrical contacts that normally clamp the block with each other, thereby creating a short circuit of the electrical contacts so that the measured electrical resistance is low. In a second example, the controller of the inhaler is configured to identify a unit with only a frame when, upon forming an electrical contact with the frame (which is formed from a substantially non-conductive material), the measured electrical resistance is high (open circuit - high or infinite resistance). Optionally, after the last used unit, there is both an empty slot and an empty frame.

Additionally or alternatively, the controller of the inhaler is configured to recognize by counting that all blocks of the cartridge starting material have been used. Additionally or alternatively, the controller of the inhaler is configured to recognize that all blocks of the cartridge starting material have been used when the end of the rotation (e.g. 360 degrees) is reached. Optionally, the controller identifies that the last "standard" block has been used and does not even approach the last slot on the carousel/only a block with a frame.

In some embodiments, upon receiving an indication that all units of the starting material in the cartridge have been used, the cartridge may be removed from the inhaler and optionally replaced with a new cartridge (1307).

Fig. 14A-B show an internal view (14A) and an external view (14B) of a linear cartridge comprising a block connector according to some embodiments.

In some embodiments, the linear cartridge 1401 comprises a plurality of blocks 1403 of the starting material, which are arranged linearly relative to each other, such as stacked on top of each other. In some embodiments, the cartridge comprises a block coupling element 1405, which is configured to engage a block of the starting material to move the block into a position for use within and/or out of the inhaler (for example, by engaging a moving member of the inhaler, not shown here). In some embodiments, the block coupling element is located in a seat 1407, through which the blocks are pulled out and/or inserted back into the cartridge. In some embodiments, the internal movement of the blocks of the starting material in the cartridge relative to the block coupling element and the seat is initiated by a spring mechanism. In other embodiments and/or in addition to the actuation of the spring, the internal movement of the blocks can be performed by an electromechanical unit, an electromagnetic unit and/or by mechanical actuation by the user.

Fig. 15A is a cross-sectional view of a cavity of the inhaler for receiving a cartridge, configured to operatively connect the cartridge to a coupling and a gear mechanism according to some embodiments.

In some embodiments, placing a cartridge (not shown) inside the cavity 1501 and/or closing the door of the inhaler lid (not shown) operatively connects the cartridge to a mechanism configured to rotate the cartridge, such as a rotating gear 1503 (it should be noted that more than one gear can be used). In some embodiments, the rotating gear is located inside the cavity. In some embodiments, the rotating gear is located directly under the surface of the cavity on which the cartridge is located.

In some embodiments, the projecting element 1505 of the inhaler body comprises an elastic element, such as a spring 1507. Optionally, when the cartridge is placed in the cavity and the lid door is closed, the lid door pushes the spring, thereby moving the clutch 1509 to engage the rotating gear 1503. The clutch 1509 may comprise a gear tooth 1510 (see Fig. 15B), from which the projecting element 1505 extends.

In some embodiments, when the inhaler is activated, the rotating gear 1503 rotates the cartridge, for example, until the selected block of the starting material is aligned with (for example, directly opposite) the opening through which the block of the starting material is pulled out for use (the opening is not shown in this figure, see, for example, the opening 1113, Fig. 11A-11B). Optionally, the movement (for example, rotation) of the plurality of blocks of the starting material and/or the indicator seats of the cartridge is carried out by means of ribs extending radially outward from the projecting element (see, for example, 1015, Fig. 10B). When the cartridge is in the cavity, the ribs engage the corresponding opening of the cartridge (for example, the opening 809, Fig. 8A).

In some embodiments, the stop position of the cartridge is detected, for example, by means of a sensor. For example, the lower surface of the rotating gear 1503, schematically shown in Fig. 15B, comprises one or more stops 1515. Optionally, the stops are distributed around the circumference, for example with a distribution that corresponds to the position of the blocks of the source material, for example one stop for two, three, four, five or an intermediate greater or lesser number of blocks. In some embodiments, the lower surface of the rotating gear is located in contact with an electronic control panel, schematically shown in Fig. 15C. The electronic control panel comprises one or more grooves 1517, wherein each groove has a shape and size for receiving a stop 1515. The groove 1517 serves as a sensor, so that upon receiving a stop, the rotation of the gear can be stopped, optionally with the installation of the cartridge blocks in the desired position and/or with the desired rotation angle.

In some embodiments, the rotating gear is activated by a stepper motor, which can advance the gear in individual steps. Optionally, a stop (not shown), such as a pin, is used to stop the rotation. Optionally, the stop is located and configured so that the carousel does not stop between pockets, such as at a boundary line between adjacent pockets.

In some embodiments, the number of projections (e.g., teeth) of the rotating gear corresponds to the number of cartridge slots, e.g., multiplied by the number of slots.

The terms "comprises," "containing," "includes," "including," "having," and their conjugations mean "including, but not limited to."

The term "consisting of" means "containing and limited to."

The term "consisting essentially of" means that the composition, method or design may contain additional ingredients, steps and/or parts, but only if the additional ingredients, steps and/or parts do not substantially change the characteristics of the claimed composition, method or design.

As used herein, the singular form includes plural references unless the context clearly dictates otherwise. For example, the term "a compound" or "at least one compound" may include multiple compounds, including mixtures thereof.

Throughout this application, various embodiments of the invention may be presented in a range format. It should be understood that a description in a range format is provided merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, a description of a range should be considered to specifically disclose all possible subranges, as well as individual numerical values within that range. For example, a description of a range such as 1 to 6 should be considered to specifically disclose subranges such as 1 to 3, 1 to 4, 1 to 5, 2 to 4, 2 to 6, 3 to 6, and so on, as well as individual numbers within that range, such as 1, 2, 3, 4, 5, and 6. This is true regardless of the width of the range.

Whenever a numerical range is stated herein, it is intended to include any recited number (fractional or whole) within the stated range. The phrases "range/ranges between" the first recited number and the second recited number and "range/ranges from" the first recited number "to" the second recited number are used interchangeably herein and are intended to include the first and second recited numbers and all fractional and whole numbers therebetween.

As used herein, the term "method" refers to methods, pathways, techniques and procedures for performing a given task, including, but not limited to, those methods, pathways, techniques and procedures that are either known or readily developed from known methods, pathways, techniques and procedures by those skilled in the art of chemistry, pharmacology, biology, biochemistry or medicine.

As used herein, the term "treating" includes stopping, substantially inhibiting, slowing or reversing the progression of a condition, substantially improving the clinical or aesthetic symptoms of a condition, or substantially preventing the occurrence of clinical or aesthetic symptoms of a condition.

It is understood that certain features of the invention that are described for clarity in the context of separate embodiments may also be provided in combination in a single embodiment. Conversely, various features of the invention that are described for brevity in the context of a single embodiment may also be provided separately or in any suitable subcombination or as appropriate in any other embodiment of the invention described. Certain features described in the context of different embodiments should not be considered as essential features of those embodiments unless the embodiment does not operate without those elements.

All publications, patents and patent applications mentioned in this specification are herein incorporated by reference in their entirety to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated by reference herein. Furthermore, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention. To the extent that section headings are used, they are not to be construed as mandatory limitations.

In addition, any priority document(s) of this application are incorporated into this specification by reference in their entirety.

Claims (13)

1. An inhaler for use with a cartridge containing blocks of starting material inside the cartridge housing, wherein the inhaler comprises an inhaler housing defining a cavity for receiving the cartridge, and a rotating gear located on the surface of the cavity for receiving the cartridge in which the cartridge is installed, or directly below it, wherein the rotating gear is configured to rotate the cartridge when it is inserted to move the blocks of starting material, at least one moving element configured to move between a proximal position inside the inhaler and a distal position in which it is configured to reach the cartridge when the cartridge is loaded into the inhaler to initiate movement of the block of starting material to the position of use in the inhaler, wherein the distal end of the moving element has a shape for attachment to a connecting element of the cartridge. 2. An inhaler according to claim 1, comprising a central protruding element attached to ribs that extend radially outward from it, wherein the ribs are designed with the possibility of engaging with a corresponding opening of the cartridge. 3. An inhaler according to claim 2, wherein the central protruding element is designed in such a way that upon contact with the cover of the inhaler housing, the central protruding element brings the clutch into engagement with the rotating gear. 4. The inhaler of claim 3, wherein the central protruding element comprises a spring. 5. An inhaler according to any one of paragraphs 1-4, in which the rotating gear is designed with the possibility of causing rotation of the blocks of the source material inside the cartridge housing. 6. An inhaler according to any one of paragraphs 1-4, in which the rotating gear is designed with the possibility of causing the cartridge body to rotate. 7. An inhaler according to any one of claims 1-4, wherein the rotating gear is designed to lock the cartridge housing inside the cavity for receiving the cartridge. 8. An inhaler according to any one of claims 1-4, comprising a motor for driving a rotating gear. 9. An inhaler according to any one of claims 1-4, wherein the number of teeth of the rotating gear corresponds to the number of blocks of the starting material in the cartridge. 10. An inhaler according to any one of claims 1-4, wherein the cavity for receiving the cartridge comprises a bump located on the side wall of the cavity for receiving the cartridge, wherein the bump is designed so that when the cartridge is rotated, the bump contacts the body of the cartridge, producing a clicking sound. 11. An inhaler according to any one of paragraphs 1-4, wherein the inhaler comprises a recess designed to be aligned with the protrusion of the cartridge upon insertion. 12. An inhaler according to claim 1, wherein the distal end of the moving element in the distal position passes next to the recess in which the protrusion of the cartridge is designed to be seated. 13. An inhaler according to any one of claims 1-4, wherein the walls of the cavity for receiving the cartridge comprise grooves configured to align with the tail projections of the cartridge connector upon insertion to guide the cartridge into the position of use.