RU2838544C1 - Miniature antibody-like control and navigation control proteins (minignc) and methods for their production and use - Google Patents

Abstract

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to polyspecific antibody-like proteins, and can be used in medicine for therapy of cancer, autoimmune disease or infectious disease.

EFFECT: designed are recombinant penta-specific antibody-like proteins (miniGNC) containing a CD3-binding domain, which enables them to act as an activator that attracts T-cells, to change the direction of T-cell-mediated cytolysis and, finally, to destroy target cells.

10 cl, 6 dwg, 9 tbl, 10 ex

Description

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to the filing date of U.S. Provisional Application No. 62/991,042, filed March 17, 2020, under 35 U.S. 119(e), the entire disclosure of which is incorporated herein by reference.

FIELD OF TECHNOLOGY TO WHICH THE INVENTION RELATES

The present application relates generally to the field of technology relating to polyspecific antibodies for cancer immunotherapy, and more particularly to the production and use of miniature guidance and navigation control (miniGNC) antibodies with binding activity to multiple surface molecules on both immune cells and tumor cells.

LEVEL OF TECHNOLOGY

Therapeutic antibodies have become a key element in the treatment of a number of diseases, including but not limited to cancer, infection, and autoimmune disorders. While monoclonal monospecific antibodies provide a simple mechanism for treating a disease, such as by inhibiting or activating specific signaling pathways, polyspecific antibodies allow the exploration of more complex therapeutic mechanisms. By targeting multiple different antigens or multiple epitopes within a single antigen, biological responses such as colocalization and cell activation can be elicited, allowing, for example, the redirection of T cells and other immune cells to the site of tumor cells expressing a specific antigen. Bispecific and polyspecific antibodies have thus become important platforms in the field of immuno-oncology.

Taking advantage of the advantages of polyspecific antibody platforms, a variety of such scaffolds have been developed. One such platform is known as Guidance and Navigation Control (GNC). GNC proteins include proteins in which multiple functionally independent binding moieties are linked into a single structure that is capable of binding to both effector and target cells (see Applicant's applications WO/2019/005641, WO2019191120, and PCT/US20/59230, all incorporated herein in their entirety). These platforms are typically limited to at least two specificities, which hinders the exploration of complex therapeutic mechanisms that require binding to more than two antigens. For antibody platforms with more than two specificities, increasing the number of binding domains typically inevitably results in large molecules that often have undesirable physical and biological properties. Increasing molecular weight may reduce their ability to unfold, as larger and more complex molecules are more likely to experience aggregation and solubility issues. In addition, the ability of large macromolecules to penetrate solid tumors may be compromised compared to smaller proteins. Thus, there is a need for polyspecific antibody platforms with more than two specificities that are not much larger than monoclonal IgG antibodies.

ESSENCE OF THE INVENTION

The following summary of the invention is illustrative only and is not intended to limit the scope of the invention in any way. In addition to the illustrative aspects, embodiments and features described above, additional aspects, embodiments and features will also become apparent from the following detailed description with reference to the drawings.

The application provides proteins with multiple binding specificities, such as antibody-like polyspecific proteins, including polyspecific antibodies, and fragments of these binding proteins, including, but not limited to, the scFv domain, the Fab region, the Fc domain, VH, VL, light chains, heavy chains, variable regions, and the complementarity determining region (CDR). The application also provides a method for producing and using the antibody-like proteins disclosed herein.

In one aspect, the application provides polyspecific antibody-like proteins. In one embodiment, a multispecific antibody-like protein with an N-terminus and a C-terminus comprises a first monomer comprising, in an N-terminal to C-terminal direction, a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain, and a first CH3 domain, wherein the first monomer may optionally comprise a first binding domain (D1) linked to the N-terminus, a fourth binding domain (D4) linked to the C-terminus, or both, and a second monomer comprising, in an N-terminal to C-terminal direction, a second binding monomer, a CL domain, a second hinge, a second CH2 domain, and a second CH3 domain, wherein the second monomer may optionally comprise a second binding domain (D2) linked to the N-terminus, a fifth binding domain (D5) linked to the C-terminus, or both, wherein the first binding monomer and the second binding monomer are engineered to form a dimer, wherein the first monomer and the second monomer are covalently paired by forming at least one a disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, wherein the polyspecific antibody-like protein is at least bispecific.

In one embodiment, the multispecific antibody-like protein may be trispecific, tetraspecific, or pentaspecific. In one embodiment, the multispecific antibody-like protein may be a monoclonal antibody. In one embodiment, the multispecific antibody-like protein may be a purified monoclonal antibody. In one embodiment, the multispecific antibody-like protein may be a humanized antibody.

In one embodiment, the multispecific antibody-like protein may further comprise a disulfide bond between the first CH3 domain and the second CH3 domain.

In one embodiment, the polyspecific antibody-like protein may further comprise a second disulfide bond between the first hinge and the second hinge.

In one embodiment, connecting linkers are used between the different domains. In one embodiment, the connecting linker may comprise a (G _x S _y ) _n linker, where each n, x and y is independently an integer from 1 to 10. In one embodiment, D1, D2, D4 or D5 are connected to the N- or C-terminus via a linker. In one embodiment, the linker may comprise a (G _x S _y ) _n linker, where each n, x, and y may independently be an integer from 1 to 10. In one embodiment, n is 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10. In one embodiment, x is 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10. In one embodiment, y is 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10.

In one embodiment, the first CH3 domain is engineered to form a cavity structure, and the second CH3 domain is engineered to form a knob structure, wherein the first CH2 and CH3 domains and the second CH2 and CH3 domains are engineered to heterodimerize to form a complementary Fc domain.

In one embodiment, the first CH3 domain may comprise at least one hole mutation that is T366S, L368A, or Y407V, and the second CH3 domain may comprise a knob mutation that is T366W.

In one embodiment, the Fc domain may comprise the mutations H435R/Y436F.

In one embodiment, the Fc domain is configured to eliminate effector cell functions selected from ADCC, ADCP or CDC.

In one embodiment, the Fc domain may comprise at least one mutation from L234A, L235A, G237A, K322A (Eu numbering). In one embodiment, the Fc region comprises the mutations L234A/L235A/G237A/K322A. In one embodiment, the Fc region comprises the mutations L234A/L235A/K322A (Eu numbering). In one embodiment, the Fc domain comprises a null mutation. In one embodiment, the Fc domain of IgG4 comprises the mutation S228P (Eu numbering). In one embodiment, the Fc domain of IgG4 comprises the mutations S228P/F234A/L234A (Eu numbering).

In one embodiment, the heavy chain constant sequence may be derived from IgG1 or IgG4.

In one embodiment, the Fc domain may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NO. 313 or 314.

In one embodiment, the first binding monomer may comprise a VH domain, the second binding monomer may comprise a VL domain, wherein the VH, CH1, VL, CL domains form a Fab region as a third binding domain (D3). In one embodiment, the Fab region may comprise a disulfide bond between 44C VH and 100C VL.

In one embodiment, the first binding monomer and the second binding monomer form an NKG2D receptor as a third binding domain (D3).

In one embodiment, D1, D2, D4 and D5 independently represent an scFv domain, a VHH domain, a receptor or a ligand.

In one embodiment, the scFv domain may comprise a VH domain linked to a VL domain. In one embodiment, the scFv domain may have a VH-VL orientation. In one embodiment, the scFv domain has a VL-VH orientation.

In one embodiment, the scFv domain may comprise a disulfide bond between VL and VH. In one embodiment, the disulfide bond is between VL100 and VH44 of the scFv domain. In one embodiment, the scFv domain may comprise a R19S mutation in VH.

In one embodiment, the VHH domain may comprise an R19S mutation in VH or VHH.

In one embodiment, at least one, two or three of D1, D2, D4 and D5 may be an scFv. In one embodiment, all of D1, D2, D4 and D5 may be an scFv.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a VHH domain. In one embodiment, all of D1, D2, D4, and D5 may be a VHH domain.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a receptor. In one embodiment, all of D1, D2, D4, and D5 may be a receptor.

In one embodiment, at least one, two, or three of D1, D2, D4, and D5 may be a ligand. In one embodiment, all of D1, D2, D4, and D5 may be a ligand.

In one embodiment, each of D1, D2, D3, D4, and D5 may independently have binding specificity for an antigen selected from a T cell activation receptor, an immune cell binding receptor, an immune checkpoint molecule, a costimulatory factor, a leukocyte receptor, a tumor antigen, a tumor-associated antigen (TAA), a tissue cell receptor, a cancer cell receptor, or a combination thereof.

In one embodiment, the binding domain for the T cell activation receptor is adjacent to the binding domain for a tumor-associated antigen (TAA).

In one embodiment, the T cell activation receptor may comprise CD3.

In one embodiment, the immune checkpoint receptor may include PD-L1, PD-1, TIGIT, TIM-3, LAG-3, CTLA4, BTLA, VISTA, PD-L2, CD160, LOX-1, Siglec-15, CD47, HVEM SIRPα CSF1R, CD73, Siglec-15, CD47, or a combination thereof.

In one embodiment, the costimulatory receptor may include 4-1BB, CD28, OX40, GITR, CD40L, CD40, ICOS, LIGHT, CD27, CD30, or a combination thereof.

In one embodiment, the tumor-associated antigen may include EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D ligand, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38, or a combination thereof.

In one embodiment, each of D1, D2, D3, D4, and D5 may independently have binding specificity for a selected antigen, EGFR, HER2, HER3, EGFRvIII, ROR1, CD3, CD28, CEA, LMP1, LMP2A, mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D, NKG2D ligand, BCMA, CD19, CD20, CD33, CD123, CD22, CD30, PD-L1, PD1, OX40, 4-1BB, GITR, TIGIT, TIM-3, LAG-3, CTLA4, CD40, CD40L, VISTA, ICOS, BTLA, LIGHT, HVEM, CSF1R, CD73, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, CD16, uPAR, sigleca-15, CD47, CD38, NKp46, PD-L2, CD160, LOX-1, SIRPα, CD27, and the Fc domain may comprise the Fc domain of human IgG.

In one embodiment, D1 may have binding specificity for CD3, CD20, CEA, HER2, EGFR, or NKG2D ligand. In one embodiment, D2 may have binding specificity for HER3, EGFR, CD3, or CD19. In one embodiment, D3 may have binding specificity for HER3, EGFR, CD3, or NKG2D ligands. In one embodiment, D4 may have binding specificity for 4-1BB or EGFR. In one embodiment, D5 may have binding specificity for PD-L1 or HER3.

In one embodiment, D1 may have binding specificity for CD3, D2 may have binding specificity for HER3, D3 may have binding specificity for EGFR, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, D1 may have binding specificity for EGFR, D2 may have binding specificity for HER3, D3 may have binding specificity for CD3, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, D1 may have binding specificity for EGFR, D2 may have binding specificity for CD3, D3 may have binding specificity for HER3, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, D1 may have binding specificity for CD3 or EGFR, D2 may have binding specificity for CD19, D3 may have binding specificity for CD3 or EGFR, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, each of D1 and D4 may have binding specificity for EGFR, each of D2 and D5 may have binding specificity for HER3, and D3 may have binding specificity for CD3.

In one embodiment, D1 may have binding specificity for CD20, D2 may have binding specificity for CD19, D3 may have binding specificity for CD3, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, D1 may have binding specificity for NKG2D ligand, D2 may have binding specificity for CD19, D3 may have binding specificity for CD3, D4 may have binding specificity for 4-1BB, and D5 may have binding specificity for PD-L1.

In one embodiment, D1 may have binding specificity for CD3, and D3 may comprise an NKG2D receptor. In one embodiment, the protein may further comprise D2 with binding specificity for CD19. In one embodiment, the protein may further comprise D5 with binding specificity for PD-L1. In one embodiment, the protein may further comprise D4 with binding specificity for 4-1BB.

In one embodiment, the multispecific antibody-like protein is bispecific. In one embodiment, D2 may have binding specificity for HER3, D3 may have binding specificity for CD3. In one embodiment, D1 may have binding specificity for HER2, D3 may have binding specificity for CD3. In one embodiment, D1 may have binding specificity for EGFR, D3 may have binding specificity for CD3. In one embodiment, D3 may have binding specificity for CD3, D5 may have binding specificity for HER3. In one embodiment, D3 may have binding specificity for CD3, D4 may have binding specificity for EGFR.

In one embodiment, the bispecific antibody-like protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NOs. 1 and 3; 5 and 7; 9 and 11; 13 and 15; 53 and 55; 57 and 59; 113 and 115; 117 and 119; 121 and 123; 125 and 127; 157 and 159; 297 and 299; or 199 and 201.

In one embodiment, the multispecific antibody-like protein is trispecific. In one embodiment, D1 may have binding specificity for EGFR, D2 may have binding specificity for HER3, D3 may have binding specificity for CD3. In one embodiment, D1 may have binding specificity for CEA, D2 may have binding specificity for EGFR, D3 may have binding specificity for CD3. In one embodiment, D3 may have binding specificity for CD3, D4 may have binding specificity for EGFR, D5 may have binding specificity for HER3. In one embodiment, the antibody is a trispecific antibody with binding specificity for EGFR, HER3, and CD3. In one embodiment, the trispecific antibody-like protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NOs. 41 and 43; 45 and 47; 49 and 51; 101 and 103; 105 and 107; 109 and 111; 195 and 197; 137 and 139; or 161 and 163.

In one embodiment, the multispecific antibody-like protein is tetraspecific. In one embodiment, D1 may have binding specificity for EGFR, D2 may have binding specificity for HER3, D3 may have binding specificity for CD3, D4 may have binding specificity for 4-1BB. In one embodiment, D1 may have binding specificity for EGFR, D2 may have binding specificity for HER3, D3 may have binding specificity for CD3, D5 may have binding specificity for PD-L1. The antibody is a tetraspecific antibody with binding specificity for EGFR, HER3, CD3, and 4-1BB. The antibody is a tetraspecific antibody with binding specificity for EGFR, HER3, CD3, and PD-L1. In one embodiment, the tetraspecific antibody-like protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NOs. 33 and 35; 37 and 39; 141 and 143; 145 and 147; or 165 and 167.

In one embodiment, the antibody is pentaspecific. In one embodiment, the antibody-like protein may have binding specificity for EGFR, HER3, CD3, 4-1BB, and PD-L1. In one embodiment, the pentaspecific antibody-like protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to SEQ ID NOs. 17 and 19; 21 and 23; 25 and 27; 29 and 31; 69 and 71; 73 and 75; 77 and 79; 81 and 83; 85 and 87; 89 and 91; 93 and 95; 97 and 99; 129 and 131; 133 and 135; 149 and 151; 169 and 171; 173 and 175; or 177 and 179.

In a second aspect, the application provides novel complementarity determining region (CDR) sequences. In one embodiment, the application provides proteins, antibody-like proteins, or antibodies comprising the CDRs provided herein.

In one embodiment, the CDRs may have an affinity for CEA. In one embodiment, the CDRs may have an equilibrium dissociation constant (KD) for CEA of no more than 0.1 nM, 2 nM, 5 nM, 10 nM, 20 nM, 30 nM, or 50 nM. In one embodiment, the CDRs may include an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 301, 302, 303, 304, 305, or 306.

In one embodiment, the application provides a protein having an affinity for CEA. In one embodiment, the protein may comprise a CDR H1 with an amino acid sequence that is at least 80% identical to SEQ ID NO. 301. In one embodiment, the protein may comprise a CDR H2 with an amino acid sequence that is at least 80% identical to SEQ ID NO. 302. In one embodiment, the protein may comprise a CDR H3 with an amino acid sequence that is at least 80% identical to SEQ ID NO. 303. In one embodiment, the protein may comprise a CDR L1 with an amino acid sequence that is at least 80% identical to SEQ ID NO. 314. In one embodiment, the protein may comprise a CDR L2 with an amino acid sequence that is at least 80% identical to SEQ ID NO. 305. In one embodiment, the protein may comprise a CDR L3 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 306. In one embodiment, the protein may include an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to an amino acid sequence selected from SEQ ID NO. 279, 280, 281 or 282. In one embodiment, the protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% or 100% identical to an amino acid sequence selected from SEQ ID NO. 279, 280, 281 or 282.

In one embodiment, the application provides a multispecific antibody-like protein with a variable region that may comprise an amino acid sequence selected from SEQ ID NO. 301, 302, 303, 304, 305 or 306.

In one embodiment, the CDRs may have an affinity for CD3. In one embodiment, the CDRs may have an equilibrium dissociation constant (KD) for CD3 of no more than 10 nM, 20 nM, 30 nM, or 50 nM, 100 nM, 200 nM, 300 nM, 400 nM, or 500 nM. In one embodiment, the CDRs may include an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 307, 308, 309, 310, 311, or 312.

In one embodiment, the protein having affinity for CD3 comprises a CDR H1 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 307. In one embodiment, the protein having affinity for CD3 comprises a CDR H2 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 308. In one embodiment, the protein having affinity for CD3 comprises a CDR H3 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 309. In one embodiment, the protein having affinity for CD3 comprises a CDR L1 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 310. In one embodiment, the protein having affinity for CD3 comprises a CDR L2 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 311. In one embodiment, the protein having affinity for CD3 comprises a CDR L3 with an amino acid sequence that is at least 80% identical to the sequence of SEQ ID NO. 312.

In one embodiment, the protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to an amino acid sequence selected from SEQ ID NOs. 227-230, 231-234, 235-238, 239-242, and 291-294. In one embodiment, the multispecific antibody-like protein may comprise an amino acid sequence that is at least 50%, 60%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99%, or 100% identical to an amino acid sequence selected from SEQ ID NO. 227-230, 231-234, 235-238, 239-242 and 291-294.

In one embodiment, the multispecific antibody-like protein may comprise a variable region that may comprise an amino acid sequence selected from SEQ ID 307, 308, 309, 310, 311 or 312.

In another aspect, the application provides isolated nucleic acid sequences encoding the polyspecific antibody-like proteins, fragments, domains, regions disclosed herein.

In another aspect, the application provides expression vectors comprising the isolated nucleic acid sequences described herein.

In another aspect, the application provides host cells comprising the isolated nucleic acid sequences provided herein. In one embodiment, the host cell comprises an expression vector provided herein. In one embodiment, the host cell may be a prokaryotic cell or a eukaryotic cell.

In another aspect, the application provides methods for producing the multispecific antibody-like proteins provided herein. In one embodiment, the method comprises the steps of culturing a host cell so that it expresses a DNA sequence encoding a multispecific antibody-like protein and purifying said multispecific antibody. In one embodiment, the method comprises the steps of culturing a host cell under conditions that produce said multispecific antibody-like proteins and isolating said antibody-like protein.

In another aspect, the application provides immunoconjugates. In one embodiment, the immunoconjugate may include multispecific antibody-like proteins linked to a cytotoxic agent, an imaging agent, or both.

In another aspect, the application provides pharmaceutical compositions. In one embodiment, the pharmaceutical composition may include a multispecific antibody-like protein and a pharmaceutically acceptable carrier. In one embodiment, the pharmaceutical composition may further include a radioisotope, a radionuclide, a toxin, a therapeutic agent, a chemotherapeutic agent, or a combination thereof. In one embodiment, the pharmaceutical composition may include an immunoconjugate disclosed herein and a pharmaceutically acceptable carrier.

In another aspect, the application provides methods for treating or preventing cancer, an autoimmune disease, or an infectious disease in a patient. In one embodiment, the method may include the steps of administering to the patient a pharmaceutical composition comprising a purified multispecific antibody-like protein, an immunoconjugate, or a pharmaceutical composition as disclosed herein. In one embodiment, the method may further include co-administering an effective amount of a therapeutic agent. In one embodiment, the therapeutic agent may comprise an antibody, a chemotherapeutic agent, an enzyme, or a combination thereof.

In one embodiment, the patient is a human. In one embodiment, the patient is a mammal. In one embodiment, the patient is a chimpanzee. In one embodiment, the patient is a pet.

In another aspect, the application provides a solution comprising an effective concentration of a multispecific antibody-like protein, immunoconjugate or pharmaceutical composition as disclosed herein. In one embodiment, the solution is the patient's blood plasma.

BRIEF DESCRIPTION OF DRAWINGS

The above and other features of the present invention will become more apparent from the following description and the appended claims with reference to the accompanying drawings. Taking into account that the drawings show only a few embodiments arranged in accordance with the disclosure, therefore, they should not be considered as limiting the scope of the invention, which is described below more specifically and in detail with reference to the accompanying drawings, in which:

Fig. 1 shows the heterodimeric configuration of miniGNC molecules with five binding domains (D1-D5), where the two monomers are encoded by chain A (N-D1-D3/VH-CH1-CH2-CH3-D4-C) and chain B (N-D2-D3/VL-CL-CH2-CH3-D5-C);

Fig. 2 shows the dimerization of engineered miniGNC chain A and chain B with knockout (KO) mutations in either VH or Fc: (2A) as determined by purification using protein A to fractionate the mixture into a homodimer (a), the desired heterodimer (b), and a B chain monomer (c); and (2B) as determined by analytical fractionation by SDS-PAGE using protein A into a homodimer (a), heterodimer (b), B chain monomer (c), and A chain monomer (d) of the expected sizes under non-reducing and reducing conditions;

Fig. 3 shows the comparative TDCC-mediated effect of polyspecific miniGNC molecules on BXPC3 tumor cells in the case of using penta-miniGNC (SI-75P6), tetra-miniGNC (SI-75E2), tri-miniGNC (SI-75X3), bi-miniGNC (SI-75X2) and mono-miniGNC (SI-75O2) molecules;

Fig. 4 shows the comparative TDCC-mediated effects of miniGNC molecules on BXPC3 tumor cell lines with EC50 values ranging from 0.1 to 5.5 pM;

Fig. 5 shows the survival curves from the TDCC assay evaluating the efficacy of (A) polyspecific miniGNC molecules with cross-linked domains, including penta-miniGNC (SI-68P1), tetra-miniGNC (SI-68E2 and SI-68E1) and tri-miniGNC (SI-68x2), in killing pancreatic cancer cells (HPAFII) in the TDCC assay and (B) SI-68X1 in killing MCF-7 breast cancer cells; and

Figure 6 shows the functionality of polyspecific miniGNC molecules containing the dimeric NKG2D receptor, including trispecific (SI-49R25), tetraspecific (SI-49P_X), pentaspecific (SI-49PM1 and SI-49P8) molecules, in killing breast cancer cells (MDA-MB-231) in the TDCC assay.

DETAILED DESCRIPTION OF THE INVENTION

The following detailed description contains reference to the accompanying drawings, which form an integral part of the description. In the drawings, like symbols generally designate like components unless the context otherwise requires. The illustrative embodiments presented in the detailed description, drawings, and claims are not intended to be limiting. Other embodiments may be utilized and other changes may be made without departing from the spirit or scope of the subject matter of the invention presented herein. It will be readily understood that aspects of the present invention, as generally disclosed in the description and illustrated in the drawings, may be rearranged, substituted, combined, separated, and constructed in a variety of configurations, all of which are expressly contemplated by the present description.

The invention relates, among other things, to isolated antibodies, methods for producing such antibodies, bispecific or multispecific molecules, antibody-drug conjugates and/or immunoconjugates consisting of such antibodies or antigen-binding fragments, pharmaceutical compositions containing antibodies, bispecific or multispecific molecules, antibody-drug conjugates and/or immunoconjugates, methods for producing molecules and compositions, and methods for treating cancer using the molecules and compositions disclosed herein.

The present application describes polyspecific guidance and navigation control (GNC) antibodies in miniature configurations (miniGNC). The molecule created on the miniGNC platform is an assembled heterodimer consisting of two polypeptide chains and is characterized by the formation of a core structure of Fab-hinge-Fc region with one, two, three or four additional binding domains (D1-D5), as shown in Fig. 1. The two polypeptides can have the following configuration: chain A (or chain 1) is N-D1-D3(VH)-CH1-hinge-CH2-CH3-D4-C; and chain B (or chain 2) is N-D2-D3(VL)-CL-hinge-CH2-CH3-D5-C. The Fc domains of the two chains are designed to contain complementary mutations, also known as "knob-into-hole" mutations, to facilitate heterodimer formation. A miniGNC platform molecule may have variable components. For example, the VH and VL regions of a Fab may be replaced by a non-Fab dimer, with or without binding specificity. The additional binding domain may be an antibody fragment such as an scFv or VHH, or a non-antibody structure such as a ligand or receptor. A miniGNC platform antibody may be divalent, trivalent, tetravalent, or pentavalent with five different specificities and have a size approximately equal (150 kDa in the case of a tri-miniGNC Ab) to or slightly larger (175 kDa in the case of a tetra-miniGNC Ab and 200 kDa in the case of a penta-miniGNC Ab) than a normal divalent IgG antibody.

The present application provides methods for producing and using miniGNC antibodies, in particular penta-specific miniGNC antibodies (penta-miniGNC Ab). In general, GNC proteins, such as GNC antibodies, are characterized by having two moieties designed to interact with immune cells, such as designed to activate T cells, when targeting tumor cells. Like GNC antibodies, miniGNC antibodies contain multiple antigen-binding domains for interacting with immune cells, such as anti-CD3 for T cell activation, anti-4-1BB for costimulation, and anti-PD-L1 for immune checkpoint inhibition. To improve the therapeutic efficacy of the antibodies in the treatment of cancer, miniGNC antibodies are designed to be structurally stable and compact while maintaining the distinctive two-moiety feature of GNC antibodies. This improvement provides additional binding specificity for a second tumor-associated antigen on the same or a different tumor cell. Compared with GNC antibodies, miniGNC contains an Fc domain, which provides FcRn-mediated recycling and increased half-life, as well as facile purification using protein A. If desired, Fc receptor-mediated immune function can be included. The miniGNC Fc-containing antibody is quite compact, which provides improved unfolding and tumor penetration. GNC antibodies are typically larger than IgG antibodies due to the increased number of antigen-binding domains (AgBDs), which provides spatial flexibility to bind to both T cells and tumor cells. On the other hand, miniGNC antibodies have a size approximately equal to that of human IgG antibodies, approximately 110-130 kDa for bispecific molecules; 120-160 for trispecific molecules; 130-190 kDa for tetraspecific molecules; and 140-220 kDa for pentaspecific molecules; compared to 150 kDa for human IgG. Incorporation of one or two scFvs into each chain may facilitate chain pairing and improve stability during navigation in the tumor microenvironment. With these distinctive features, GNC and miniGNC antibodies may be an alternative to effective antibody therapy in the treatment of the same cancer, as they contain the same fragments targeting tumor-associated antigens, including but not limited to EGFR, HER2, HER3, EGRFVIII, CD19, BCMA, CD20, CD33, CD123, CD22, CD30, ROR1, CEA, LMP1, LMP2A, mesothelin, PSMA, EpCAM, glypican-3, gpA33, GD2, TROP2, NKG2D ligand, CD39, CLDN18.2, DLL3, HLA-G, FcRH5, GPRC5D, LIV-1, MUC1, CD138, CD70, uPAR, CD38.

The term "antibody" is used in the broadest sense and specifically encompasses single monoclonal antibodies (including agonist and antagonist antibodies), compositions of antibodies with polyepitope specificity, and antibody fragments (e.g., Fab, F(ab') ₂ and Fv), so long as they exhibit the desired biological activity. In some embodiments, the antibody may be a monoclonal, polyclonal, chimeric, single-chain, bispecific or bipotent, human and humanized antibody, as well as an active fragment thereof. Examples of active fragments of molecules that bind known antigens include Fab, F(ab') ₂ , scFv and Fv fragments, including Fab immunoglobulin expression library products and epitope-binding fragments of any antibodies and the aforementioned fragments. In some embodiments, the antibody may include immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e. molecules that contain a binding site that immunospecifically binds to an antigen. The immunoglobulin can be of any type (IgG, IgM, IgD, IgE, IgA, and IgY) or class (IgG1, IgG2, IgG3, IgG4, IgA1, and IgA2) or subclass of an immunoglobulin molecule. In one embodiment, the antibody can be a whole antibody and any antigen-binding fragment derived from the whole antibody. An exemplary antibody is a heterotetrameric protein typically consisting of two heavy (H) chains and two light (L) chains. Each heavy chain consists of a heavy chain variable domain (abbreviated VH) and a heavy chain constant domain. Each light chain consists of a light chain variable domain (abbreviated VL) and a light chain constant domain. The VH and VL regions can be further subdivided into domains of hypervariable complementarity-determining regions (CDRs) and more conserved regions called framework regions (FRs). Each variable domain (either VH or VL) typically consists of three CDRs and four FRs arranged in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4 in the amino-terminus to carboxy-terminus direction. Within the variable regions of the light and heavy chains are binding regions that interact with antigen.

As used herein, the term "monoclonal antibody" refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible natural mutations that may be present in minor amounts. Monoclonal antibodies are highly specific and are directed against a single antigenic site. Furthermore, unlike conventional (polyclonal) antibody preparations, which typically include different antibodies directed against different determinants (epitopes), each monoclonal antibody is directed against a single determinant on the antigen. In addition to their specificity, monoclonal antibodies have the advantage of being synthesized by hybridoma culture uncontaminated by other immunoglobulins. The modifier "monoclonal" indicates that the antibody is obtained from a substantially homogeneous population of antibodies and should not be construed as requiring production of the antibody by any particular method. For example, monoclonal antibodies useful in accordance with the present invention can be produced by the hybridoma method first described by Kohler & Milstein, Nature, 256:495 (1975), or can be produced by recombinant DNA techniques (see, e.g., U.S. Patent No. 4,816,567).

Monoclonal antibodies may include "chimeric" antibodies (immunoglobulins) in which a portion of the heavy and/or light chain is identical to or homologous with corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is identical to or homologous with corresponding sequences in antibodies derived from another species or belonging to a different antibody class or subclass, as well as fragments of such antibodies, if they exhibit the desired biological activity (U.S. Patent No. 4,816,567 and Morrison et al., Proc. Natl. Acad. Sci. USA, 81:6851-6855 [1984]).

Monoclonal antibodies can be produced by a variety of methods, including mouse hybridoma or phage display (for review, see Siegel. Transfus. Clin. Biol. 9:15-22 (2002)) or by molecular cloning of antibodies directly from primary B cells (see Tiller, New Biotechnol., 28:453-7 (2011)). In the present invention, antibodies are produced by immunization of rabbits, mice, or llamas in combination with subsequent strategies such as hybridoma or display. Rabbits are known to produce antibodies that have high affinity and are diverse and specific (Weber et al. Exp. Mol. Med. 49:e305). In addition to immunization of rabbits followed by B cell culture, other commonly used strategies for antibody production and identification include immunization of other animals (e.g., mice, llamas) followed by hybridoma production and/or display on phage, yeast, or mammalian cells; or display using synthetic libraries of variant genes. This general method for antibody identification is similar to that described by Seeber et al. PLOS One. 9:e86184 (2014).

The term "antigen- or epitope-binding portion or fragment" refers to fragments of an antibody that are capable of binding to an antigen. These fragments may perform the antigen-binding function and additional functions of the intact antibody. Examples of binding fragments include, but are not limited to, a single-chain Fv fragment (scFv), consisting of the VL and VH domains of one arm of an antibody joined into a single polypeptide chain by a synthetic linker, or a Fab fragment, which is a monovalent fragment consisting of a VL domain, a light chain constant domain (CL), VH, and a heavy chain constant domain 1 (CH1). Antibody fragments may be smaller subfragments and may consist of domains the size of a single CDR domain, in particular the CDR3 regions of either the VL domain and/or the VH domain (see, for example, Beiboer et al., J. Mol. Biol. 296:833-49 (2000)). Antibody fragments are prepared by conventional methods known to those skilled in the art. Antibody fragments may be screened for suitability using the same methods as intact antibodies.

"Antigen- or epitope-binding fragments" can be obtained from an antibody of the present invention by several methods known in the art. For example, purified monoclonal antibodies can be digested with an enzyme such as pepsin and subjected to gel filtration by HPLC. The corresponding fraction containing the Fab fragments can then be collected and concentrated by membrane filtration, etc. For further descriptions of general methods for isolating active antibody fragments, see, for example, Khaw, B.A. et al. J. Nucl. Med. 23:1011-1019 (1982); Rousseaux et al. Methods Enzymology, 121:663-69, Academic Press, 1986.

Papain digestion of antibodies produces two identical antigen-binding fragments called Fab fragments, each with one antigen-binding site, and a remaining Fc fragment, whose name reflects its ability to crystallize readily. Pepsin treatment produces an F(ab') ₂ fragment, which has two antigen-binding sites capable of binding antigen.

The Fab fragment may comprise the constant domain of the light chain and the first constant domain (CH1) of the heavy chain. Fab' fragments differ from Fab fragments by the addition of several residues at the carboxy terminus of the CH1 domain of the heavy chain, including one or more cysteines of the hinge region of the antibody. As used herein, Fab'-SH is used to designate Fab' in which the cysteine residue(s) of the constant domains bear a free thiol group. F(ab') ₂ antibody fragments are initially prepared as pairs of Fab' fragments with hinge cysteines between them. Other chemical linkages linking antibody fragments are also known.

"Fv" is the smallest antibody fragment that contains a complete antigen-recognition and -binding site. This site consists of a dimer of one heavy-chain variable domain and one light-chain variable domain in tight non-covalent association. It is in this configuration that the three CDRs of each variable domain interact to define the antigen-binding site on the surface of the VH-VL dimer. Together, the six CDRs confer antigen-binding specificity to the antibody. However, even a single variable domain (or half of an Fv, containing only the three CDRs specific for an antigen) has the ability to recognize and bind antigen, although with lower affinity than the complete binding site.

The "light chains" of antibodies (immunoglobulins) from any vertebrate species can be classified into one of two distinct types, called kappa (κ) and lambda (λ), based on the amino acid sequences of their constant domains.

Depending on the amino acid sequence of the constant domain of the heavy chains, immunoglobulins can be classified into different classes. There are five main classes of immunoglobulins: IgA, IgD, IgE, IgG, and IgM, and some of them can be further divided into subclasses (isotypes), such as IgG-1, IgG-2, IgG-3, and IgG-4; IgA-1 and IgA-2. The constant domains of the heavy chain that correspond to the different immunoglobulin classes are called α, delta, epsilon, γ, and μ, respectively. The subunit structures and three-dimensional configurations of the different immunoglobulin classes are well known.

A "humanized antibody" refers to a type of engineered antibody whose CDRs are derived from a non-human donor immunoglobulin and the remaining immunoglobulin-derived portions of the molecule are derived from one or more human immunoglobulins. In addition, framework residues may be altered to maintain binding affinity. Methods for producing "humanized antibodies" are well known to those skilled in the art. (See, e.g., Queen et al., Proc. Natl Acad Sci USA, 86:10029-10032 (1989), Hodgson et al., Bio/Technology, 9:421 (1991)).

In the context of the present description, the terms “polypeptide,” “peptide,” and “protein” are interchangeable and mean biomolecules consisting of amino acids linked by a peptide bond.

As used herein, the terms “a,” “an,” and “the” mean “one or more” and include plurals unless the context otherwise requires.

"Isolated" refers to a biological molecule that is free of at least some of the components with which it is found in nature. "Isolated," when used to describe the various polypeptides disclosed herein, means a polypeptide that has been identified, separated, and/or recovered from the cell or cell culture in which it was expressed. Typically, an isolated polypeptide is obtained by at least one purification step. "Isolated antibody" refers to an antibody that is substantially free of other antibodies that have different antigen-binding specificities.

"Recombinant" means that the antibodies are produced by recombinant nucleic acid techniques in exogenous host cells.

The term "antigen" refers to an agent or fragment thereof that can induce an immune response in an organism, particularly an animal, more particularly a mammal, including humans. The term includes immunogens and their antigenic regions, or antigenic determinants.

In addition, in the context of the present description, the term "immunogenic" refers to substances that induce or enhance the production of antibodies, T cells or other reactive immune cells directed against an immunogenic agent and promote an immune response in humans or animals. An immune response occurs when an individual produces a sufficient number of antibodies, T cells and other reactive immune cells in response to the administered immunogenic compositions of the present invention to mitigate or alleviate the disease being treated.

"Specifically binding" or "specifically binds to" or is "specific" with respect to a particular antigen or epitope means binding that is distinctly different from non-specific interaction. Specific binding can be measured, for example, by determining the binding of the molecule compared to the binding of a control molecule, which is typically a molecule of similar structure that lacks binding activity. For example, specific binding can be determined by competition with a control molecule that is similar to the target.

The term "affinity" refers to a measure of attraction between two polypeptides, such as an antibody/antigen, receptor/ligand, etc. The intrinsic attraction between two polypeptides can be expressed by the equilibrium binding affinity dissociation constant (KD) for a particular interaction. The binding affinity constant KD can be measured, for example, by biolayer interferometry, where KD is the ratio of kdis (dissociation rate constant) to kon (association rate constant), in the form KD=kdis/kon.

Specific binding to a particular antigen or epitope can be observed, for example, in an antibody with a KD for the antigen or epitope of at least about ^10-4 M, at least about ^10-5 M, at least about ^10-6 M, at least about 10-7 M, at least about ^10-8 M, at least about ^10-9 M, alternatively at least about ^10-10 M, at least about ^10-11 M, at least about ^10-12 M or more, wherein the KD refers to the equilibrium dissociation constant of the particular antibody-antigen interaction. Typically, the KD of an antibody that specifically binds to an antigen will be 20-fold, ⁵⁰ -fold, 100-fold, 500-fold, 1000-fold, 5000-fold, 10000-fold or more higher for a reference molecule than for the antigen or epitope.

In addition, specific binding of a particular antigen or epitope can be observed, for example, in an antibody in which the KA or Ka for the antigen or epitope is at least 20, 50, 100, 500, 1000, 5000, 10000 or more times greater than that of a reference molecule, where the KA or Ka refers to the rate of association of a particular antibody-antigen interaction.

"Homology" between two sequences is determined by sequence identity. If the two sequences being compared differ in length, sequence identity preferably refers to the percentage of nucleotide residues of the shorter sequence that are identical to the nucleotide residues of the longer sequence. Sequence identity can be determined in a conventional manner using computer programs. Deviations that occur when comparing a certain sequence with the above-described sequences of the invention can be caused, for example, by addition, deletion, substitution, insertion or recombination.

The present invention will become more clearly understood from the following detailed description of specific embodiments and examples included herein. Although the present invention has been described with reference to specific details of some embodiments thereof, such details should not be construed as limiting the scope of the invention.

EXAMPLES

Example 1: Configuration of miniGNC penta-specific antibodies

The construction of miniGNC antibodies is based on the coexpression and assembly of two polypeptide chains of the heterodimer, chain A and chain B (Fig. 1). While chain A may be the native heavy chain (HC), chain B is a recombinant fusion peptide consisting of the light chain and the Fc domain of HC. The core of the antibody structure is the Fab region (VH-CH1/VL-CL) followed by the hinge and Fc region (CH2-CH3/CH2-CH3) of human IgG1. Knob-into-hole mutations or other complementary sets of mutations can be introduced into the CH3 domains to destabilize the homodimers and facilitate heterodimer formation (Ridgway JB, Presta LG, Carter P, Protein Eng 1996; 9:617-21). The hole mutations in the CH3 domain of chain A consist of T366S, L368A, and Y470V, while the knob mutation in the CH3 domain of chain B is T366W. The knob formed by the T366W mutation in chain B preferentially interacts with the hole formed by the three mutations in chain A. This preferential pairing may further stabilize the heterodimer, with non-covalent pairing of the Fab domain components (i.e., between VH-CH1 of chain A and VL-Ck of chain B) resulting in the formation of the functional Fab region. In other words, a functional D3 binding domain, such as a functional Fab region or a non-Fab receptor dimer, can only be obtained in chain A-chain B heterodimers. Compared with GNC antibodies, miniGNC antibodies also contain antibody fragments from native IgG (Fab, Fc) and other variable sequence-based structures such as scFv and VHH, but are designed in such a way that after heterodimer formation, a Fab region-hinge region-Fc region structure is preferentially formed. A characteristic feature of miniGNC antibodies is the compactness of such a recombinant structure.

One or more structurally diversified antigen-binding domains, such as D1, D2, D4 or D5, may be added to the two N-termini and two C-termini of the miniGNC molecule, thereby obtaining up to five binding specificities. Each of these added binding domains may be a variable sequence-based structure, such as scFv and VHH, or a non-variable sequence-based structure, such as a ligand and a receptor. As shown in Fig. 1, D1 and D2 refer to the binding domains attached to the N-termini of chain A and chain B, respectively, while D4 and D5 refer to the binding domains attached to the C-termini of chain A and chain B, respectively. Thus, two penta-specific miniGNC antibody polypeptides (penta-miniGNC) may have the following structure:

Chain A: N-D1-D3(VH)-CH1-hinge-CH2-CH3-D4-C; and

Chain B: N-D2-D3(VL)-CL-joint-CH2-CH3-D5-C;

where VL can be either Vλ or Vκ, and CL can be either Vλ or Vκ, as shown in Fig.1.

Depending on the number of binding domains and their binding specificity, the structural configuration of the penta-miniGNC antibody shown in Fig. 1 can be simplified by removing one or more binding domains and converting it into tetra-, tri-, and bi-miniGNC. As an example, Table 1 shows the production and characterization of the miniGNC family of anti-CD3 antibodies to optimize their efficacy in targeting EGFR and HER3. In this case, each binding domain exhibits one binding specificity. If two of the five binding domains target the same epitope of the antigen, i.e., have the same binding specificity, the penta-miniGNC antibody becomes a tetra-specific penta-miniGNC antibody.

Example 2: Engineered nuclear structure of miniGNC antibodies

To demonstrate that the miniGNC configuration can be translated into a stable and functional heterodimeric protein, a simplified asymmetric format was created to assess the effect of configuration and mutations on heterodimer formation of miniGNC molecules. Briefly, one scFv (D1) was fused to the N-terminus of chain A, while chain B did not contain the additional binding domain. Thus, the proportion of each dimerization mode between chains A and B could be determined by SDS-PAGE and SEC according to the predicted sizes of chain A homodimer (not observed), chain B homodimer, and heterodimer composed of chain A and chain B of 100 kDa, 150 kDa, and 125 kDa, respectively (Fig. 2).

To develop a strategy for the selective purification of the miniGNC heterodimeric molecule from the mixture, two amino acid residues in the CH3 domain (H435 and Y436) of the B chain were substituted. In particular, during the purification of therapeutic antibodies, histidine (H435) is critical for the binding of the B chain to Protein A resins (Tustian et al., 2016), and substitution of this amino acid or knockout mutation of ProA (ProAKO) abolishes binding to Protein A. This strategy allows for the separation of the heterodimer by selective elution from the Protein A column. Since the Protein A column retains the heterodimer by interacting with the parental heavy chain binding site, the B chain homodimer passes through the resin since the B chain does not bind to Protein A. The ProAKO design of the B chain minimizes any potential issue associated with altered immunogenicity due to amino acid substitutions in the Protein A binding site with residues from the homologous region IgG3 subclass. Although most miniGNC molecules may predominantly incorporate the structure and sequence of the IgG1 subtype, the overall structure of IgG3 is similar to other IgG subclasses but has some specific structural alterations that affect binding to protein A, protein G, and FcRn (neonatal Fc receptor). This difference is based on a previously identified difference in Fc sequences in which the presence of R435 (instead of H435 as in other subtypes) in IgG3 abolishes Fc interaction with protein A. Therefore, in representative miniGNC molecules, amino acids critical for protein A binding to the miniGNC B chain (H435 and F436) were replaced with the corresponding IgG3 sequences (R435 and Y436).

In the miniGNC class of polyspecific antibodies with an added scFv fused to the N-terminus of the B chain, interaction via protein A binding is still possible if the scFv is from the VH3 family. VH3-encoded antibodies are known to interact with staphylococcal protein A (SPA), and residues in FR1, CDR2, and FR3 have been identified as involved in SPA binding (Roben, et al., 1995), with structural data indicating that replacement of one involved region with the corresponding region from a non-binding immunoglobulin abolishes protein A binding to VH3-encoded antibodies. An amino acid substitution at R19 in FR1 was found to be critical for protein A binding and was replaced with an amino acid sequence (S19) from the equivalent region of the VH4 family.

Four sets of miniGNC molecules (SEQ IDs 1-16) with four different B chain mutation patterns (SEQ IDs 3, 7, 11, and 15) comprising different combinations of ProAKO H435R/Y436F (Fc) and R19S (VH) were purified and analyzed by analytical size exclusion chromatography. Only the protein containing the B chain with both sets of mutations allowed complete removal of the B chain contaminant (Fig. 2A). This VH3 (R19S) knockout mutation in protein A, together with the Fc (H435R, F436Y) mutations in the B chain, knockout in protein A, were incorporated into most polyspecific antibody formats and used to generate bi-, tri-, tetra-, and penta-miniGNC molecules.

To demonstrate the feasibility of generating functional miniGNC proteins with alternative antibody isotypes, an illustrative miniGNC containing IgG4 constant regions was generated. SI-75XM9 (SEQ IDs 297-300) is similar to the bispecific miniGNC SI-75X5 (SEQ IDs 1-4) except that CH1, hinge, and Fc of IgG1 were replaced with CH1, hinge, and Fc of IgG4. Notably, both proteins had the same binding domains (anti-HER3 domain D2 and anti-CD3* domain D3) and the same core structure and mutations (knob-into-hole mutation in Fc; R19S in anti-HER3 scFv; and H435R/Y436F mutations in Fc). As shown in Table 8, SI-75XM9 had a titer comparable to that of SI-77X5, and after purification using Protein A, the percentage of protein of interest was significantly increased by 19% (85.6% POI vs. 72.2% POI) according to the analytical SEC results. The decrease in high molecular weight compounds may be due to the shorter hinge length of IgG4 (12 amino acids instead of 15), which may reduce the propensity for higher order oligomer association. Thus, the production of miniGNC proteins with alternative antibody isotypes is not only possible, but may also result in more favorable properties such as reduced aggregation ability.

Example 3: Configuration of miniGNC polyspecific antibodies

To generate and characterize the first group of polyspecific miniGNC antibodies, three fragment 1-binding domains, i.e., αCD3, αPD-L1, and α4-1BB, and two fragment 2-binding domains targeting EGFR and HER3, respectively, were selected for comparison. As shown in Table 1, the group was divided into penta-miniGNC, tetra-miniGNC, tri-miniGNC, and bi-miniGNC groups. Each subgroup contained at least one miniGNC antibody with CD3-binding D3. The penta-miniGNC group included SI-75P6 (SEQ ID 17, 19, with αEGFR in D3), SI-75P4 (SEQ ID 21, 23, with 41BBL, a ligand to the 4-1BB receptor, in D4), SI-75P3 (SEQ ID 25, 27) and SI-75P9 (SEQ ID 29, 31, with αHER3 in D3). The tetra-miniGNC group included two antibodies SI-75E1 (SEQ ID 33, 35) and SI-75E2 (SEQ ID 37, 39) to compare the effect in the presence and absence of the α4-1BB domain or αPD-L1. The tri-miniGNC group included three antibodies SI-75X3 (SEQ ID 41, 43), SI-75X16 (SEQ ID 45, 47), and SI-75X18 (SEQ ID 49, 51) to compare the two fragment 2-binding domains at either the N- or C-terminus of the heterodimer. The bi-miniGNC group included three antibodies SI-75X1 (SEQ ID 53, 55), SI-75X2 (SEQ ID 57, 59), and SI-75X5 (SEQ ID 1, 3), each with one fragment 1-binding domain and one fragment 2-binding domain.

DNA encoding each member of the first miniGNC antibody group was cloned into the pTT5 vector, which was expressed at acceptable titers using ExpiCHO expression systems for 9 days. The miniGNC antibodies were purified by passing through a 5 ml MabSelect protein A column, followed by size exclusion chromatography through a 200 pg preparative SEC highload 16/600 column on an Akta Avant or Purifier system. SEC aggregates were analyzed using a Waters HPLC system with a multi-angle light scattering detector (MALS, Wyatt systems) to determine the correct molecular weight by calculating dn/dc.

Example 4: Octet analysis for determining binding affinity

To evaluate the functionality of the miniGNC antibodies, the binding affinity of each domain was determined using biolayer interferometry (Octet 384 system). Octet assay was used to ensure that the selected miniGNC antibody maintains specificity and binding affinity for all cognate antigens. Each miniGNC antibody was loaded onto the AHC sensors for 180 seconds at a concentration of 10 μg/mL, followed by a baseline step for 60 seconds, a binding step with 100 nM commercially purchased human antigen for 180 seconds, and a dissociation step for 360 seconds. Samples for all steps were in Octet buffer (PBS containing 0.1% Tween 20 and 1% BSA). Curve fitting was performed to a 1:1 binding model to generate binding affinity KD values. As shown in Table 1, the binding affinity of each binding domain, as measured by its KD, varies within a reasonable range. For fragment 1 binding, the domain KD for aCD3 can range from 17.4 to 36.2 nM, for αPD-L1 from 1 to 2.72 nM, and for α4-1BB from 7.51 to 37.3 nM; for fragment 2 binding, the KD for αEGFR ranges from 5.56 to 11.1, and for aHER3 from 112.8 to 185 nM.

Example 5: Comparative efficacy of miniGNC polyspecific antibodies

The first group of miniGNC polyspecific antibodies was analyzed for T cell-dependent cellular cytotoxicity (TDCC) to measure the ability of the antibodies to kill cancer cells. With an αCD3-binding domain in all molecules, this group of miniGNC antibodies was able to act as an activator to attract T cells, reverse T cell-mediated cytolysis, and ultimately kill the target cells.

A luminescence-based T cell-dependent cellular cytotoxicity (TDCC) assay was used to measure the extent of antibody-induced cellular cytotoxicity by quantifying cell viability through constitutive expression of luciferase. Luciferized human pancreatic cancer cell lines BXPC3 (ATCC, Manassas, VA) were cultured at 37°C, 5% _CO2 in RPMI medium (ATCC, Manassas, VA) with 10% heat-inactivated fetal bovine serum (Invitrogen, Waltham, MA). Cell viability was monitored using a Vi-CELL automated cell counter (Beckman Coulter, Pasadena, CA). Target cell surface expression was measured by flow cytometry. BXPC3 human pancreatic cancer cells were co-cultured with human pan-T cells at an effector-to-target (E:T) ratio of 5:1, and antibodies were added at 5-fold serial dilutions (0-30 nM). Using a Multidrop liquid dispenser (BIOTEK, Winooski, VT), 500 target cells/well (20 μl/well) and 2500 T cells/well (20 μl/well) were sequentially added to TC-treated 384-well white flat-bottomed polystyrene microplates (Corning, Corning, NY). Antibody dilutions (10 μl/well) were added, and the plates were incubated for 72 h at 37°C, 5% _CO2 before luminescence-based quantification of cell viability. 20 µl of Bright-Glo (Promega) were added to the wells and luminescence corresponding to tumor cell viability was determined using a CLARIOstar plate reader.

The data were fitted to a sigmoid function to calculate the EC50 values, which are listed in Table 1 for comparison. Figure 3 shows the dose-response curves of cell viability obtained using miniGNC antibodies selected from penta-miniGNC (SI-75P6), tetra-miniGNC (SI-75E2), tri-miniGNC (SI-75X3), bi-miniGNC (SI-75X2), and mono-miniGNC (SI-75O2). Although all polyspecific miniGNC antibodies were able to completely kill BXPC3 cells, both penta- and tetra-miniGNC antibodies showed consistently high potency in the pM EC50 range. SI-75X1 was particularly effective in this regard. The data demonstrate the important role of fragment 1 binding domains, in particular the αPD-L1 domain, as an immune checkpoint inhibitor in targeting BXPC3 cancer cells.

Example 6: Configuration of the CD3-binding domain in miniGNC antibodies

By definition, a miniGNC antibody is capable of interacting with at least one immune effector cell and one target cancer cell via binding of its fragment 1 and fragment 2 binding domains, respectively. Using the general configuration scheme of a miniGNC antibody (Fig. 1), it is possible that placement of the two fragment 2 binding domains on D1 and D2 may result in a potency that differs when placed on D1 and D4 or D2 and D5 due to the different relative positions of the targets on the cell surface, either above and below or on both sides. In this context, a second group of penta-miniGNC antibodies was configured and are summarized in Table 2. This group of minGNC antibodies has the same binding specificity for CD3, CD19, EGFR, 4-1BB, and PD-L1, as well as the same binding domains on D2, D4, and D5. SI-68P13 (SEQ ID 69, 71) has an αCD3 domain at D3, which is comparable to that of SI-75P3 of the first group, except for the difference at D2, i.e. αCD19 instead of αHER3, and is also comparable to that of SI-68P17 (SEQ ID 73, 75) of the second group, except for the switch of the αCD3 domain to D1. The remaining miniGNC antibodies of the second group have binding specificities similar to D1 (αCD3) and D3 (αEGFR) of SI-68P17 (with binding specificities for CD19, 4-1BB and PD-L1, respectively).

Anti-CD3 antibody plays a central role in immune therapy based on T cell activation. It is desirable to use a humanized antibody for the development of a therapeutic antibody. The CD3 domain was inserted at positions D1 and D3 to obtain SI-68P17 (SEQ ID 73, 75) and SI-68P13 (SEQ ID 69, 71) to test the positional effect. The anti-CD3 sequences in humanized framework 1 (CD3**), 2 (CD3***), 3 (CD****) and 4 (CD*****) were cloned into the expression cassette to generate SI-68P15 (SEQ ID NOs: 77, 79), SI-68P18 (SEQ ID 81, 83), SI-68P19 (SEQ ID 85, 87) and SI-68P16 (SEQ ID 89, 91) (Table 2). Each expression cassette was transfected into 25 ml ExpiCHO and expressed for 8 days, followed by protein A affinity chromatography to collect and purify each penta-miniGNC antibody. The antibodies were obtained in good titer (Table 2). The octet was used to test that penta-miniGNC antibodies containing different domains of CD3 could bind to human CD3, respectively (Table 2). Each penta-miniGNC antibody was loaded onto the AHC sensors at a concentration of 10 μg/mL and bound to human His-tagged CD3 at a serial dilution (maximum concentration 200 nM, dilution 1:2.5) or a single concentration of 100 nM. The curve obtained from a global fit to a 1:1 binding model showed that penta-GNC antibodies bind to CD3 with an affinity in the low nanomolar range (Table 2).

To assess the effect of CD3-mediated T cell cytotoxicity directed against cancer cells, the BXPC3 tumor cell line was used as a target. Serial dilutions (0 to 30 nM; dilution factor 1 to 5) of antibodies were added to a white 384-well plate containing luciferized target cells and activated T cells (which were added to the plate immediately before drug administration; effector:target = 5:1) in a total volume of 50 μl. After an additional 72 h, 20 μl of Bright-Glo (Promega) were added to the wells and luminescence corresponding to the viability of luciferized tumor cells was determined using a CLARIOstar plate reader. The data were fitted to a sigmoid function to calculate EC50 values, which ranged from 0.1 to 5.5 pM, as shown in Fig. 4 and Table 2. The data demonstrate that there is some flexibility in anti-CD3 location, configuration and binding affinity.

Example 7. Polyspecific miniGNC antibodies containing VHH as binding domains

For a multispecific antibody platform such as GNC and miniGNC antibodies that contain multiple scFv domains, a potential problem is mispairing caused by the presence of multiple VH and VL domains in a single molecule. Different VH and VL domains have different propensities to interact with each other. If binding domains with different specificities have high interaction energies, mispairing may occur during protein assembly. As a result, none of the binding domains will bind to their target antigens.

VHH refers to antibodies with single Ig, i.e., “heavy chain only” domains, also known as single-domain antibodies (sdAbs) or nanobodies. The first single-domain antibodies were constructed from heavy chain antibodies found in camelids, also known as V _H H fragment (VHH). VHH domains are increasingly being incorporated into antibody therapeutics due to several favorable properties. VHH domains may have increased stability and solubility compared to the more traditionally used scFv domains. Although the VH/VL interface of traditional antibody variable regions is hydrophobic, transient exposure to these surfaces can result in significant aggregation or precipitation. VHH domains, on the other hand, have an inherently more hydrophilic surface and may therefore have superior solubility and stability properties. An obvious advantage of VHH domains compared to Fab or scFv domains is their small size. Where Fab domains are approximately 50 kDa in size and scFv domains are approximately 25 kDa, VHH domains are very compact, 12-15 kDa. Penta-miniGNC antibodies contain five binding domains (Fig. 1). Incorporation of VHH domains in place of scFv domains allows for a significant reduction in molecule size and increased tumor penetration.

A third group of polyspecific miniGNC antibodies containing EGFR- and HER3-binding VHH domains were designed and constructed (Gottlin et al., 2009; Eliseev et al., 2018) (Table 3). miniGNC molecules containing penta-, tri-, and bispecific single-domain variable regions (VHH) were created and purified to an acceptable titer. The binding activity of each domain of the polyspecific miniGNCs: SI-75P5 (SEQ ID 93, 95), SI-75P8 (SEQ ID 97, 99), SI-75X4 (SEQ ID 101,103), SI-75X17 (SEQ ID 105, 107), SI-75X19 (SEQ ID 109, 111), SI-75X9 (SEQ ID 113-115), SI-75X11 (SEQ ID 117, 119), SI-75X15 (SEQ ID 121, 123), and SI-75X13 (SEQ ID 125, 127), was assessed using Octet. AHC sensors were used to capture the GNC antibody at a concentration of 10 μg/mL for 180 seconds. Following a 60-second baseline step, a single antigen concentration was used in a 180-second association step. Antigens tested included 200 nM human EGFR (laboratory purified), 100 nM human CD3 (Acro CDD-H52W1), 20 nM human PD-L1 (Acro PD1-H5229), 400 nM human 4-1BB (laboratory purified), 200 nM human HER3 (Acro ER3-H5223). Association was followed by a 420-second dissociation step. Tabulated K _D values were calculated using the one-to-one binding model using ForteBio data analysis software version 11. The data showed that all VHH-enabled domains of the miniGNC platform retain high affinity.

To assess T cell-mediated cytotoxicity directed against cancer cells, the BXPC3 tumor cell line was used as a target. Antibodies were added in serial dilutions (0 to 30 nM; dilution factor 1 to 5) to a white 384-well plate containing luciferized target cells and activated T cells (added to the plate immediately before drug addition; effector:target = 5:1) in a total volume of 50 μl. After another 72 h, 20 μl of Bright-Glo (Promega) were added to the wells and luminescence corresponding to the viability of luciferized tumor cells was determined using a CLARIOstar plate reader. EC50 values are given in Table 3.

Example 8. Engineered Fab (D3) domain to improve protein expression and quality

An optional disulfide crosslink was introduced at the VH-VL interface of the fab region (Fig. 5). The purpose of this design was to improve pairing of the heterodimers and stabilize the overall structure by forming a covalent disulfide bond (Weatherill et al., 2012) at the core-fab interface. A pair of cysteines was optionally introduced to form a disulfide bond in the V _L A100 of the B chain and the corresponding V _H A44 of the A chain of the fab region.

To analyze the effect of variable region cross-linking in Fab, a pair of penta-miniGNC antibodies (SI-38P11 and SI-76PM1) (SEQ ID NOs. 129 and 131; 133 and 135) with identical binding specificities were generated. Chain A of the two antibodies contained αCD20 scFv at D1, αCD3 VH at D3 (VH Fab-CH1-Fc) and α4-1BB at D4, while chain B contained αCD19 at D2, αCD3V _L at D3 (VKappa Fab CL-Fc) and αPD-L1 scFv at D5 (Table 4) according to the naming system as shown in Fig. 1. SI-76PM1 was generated with an additional disulfide bond in D3 (VH/VL Fab-CH1/CL-Fc), and SI-38P11 was generated by pairing VH/VL fab without additional disulfide bonds.

Penta-miniGNC antibody constructs with and without a disulfide cross-link at position D3 were expressed in the ExpiCHO system. The construct with the cross-linked D3 (SI-76PM1) was obtained with a significantly higher titer than SI-38P11. Both proteins were purified using a 5 ml MabSelect protein A column followed by size exclusion chromatography on a preparative 200 pg hiload 16/600 SEC column in an Akta Avant or Akta Pure Purifier system. SEC aggregates were analyzed by Waters HPLC coupled to a multi-angle light scattering detector (MALS, Wyatt systems) to determine the correct molecular weight by calculating dn/dc. In all assays performed, as shown in Table 4, the yield of the penta-miniGNC antibodies of interest, i.e., "cross-linked Fab D3" was 5% higher. Both molecules showed comparable antigen binding kinetics (Table 4).

Example 9. Polyspecific miniGNC antibodies with cross-linked scFv binding domains

The core structure of the polyspecific miniGNC molecules was designed to provide several features that stabilize the heterodimer, including a covalently linked hinge and a non-covalent and preferential knob-into-hole interaction between the CH3 domains in the Fc region. Given the preference for stability and compactness, it remains unclear whether the closer proximity of D1 and D2 or D3 and D4 may affect their stability and independent function. To maintain the stability and independence of each added binding domain, one option is to introduce a disulfide bond between V _L 100 and V _H 44 in each scFv domain, i.e., cross-linking each scFv domain. The disulfide bond between V _L and V _H can be used in all scFv domains to stabilize the overall structure. Alternatively, a disulfide bond can be introduced into at least one selected scFv domain at any position.

To compare the TDCC efficacy against pancreatic cancer cells (HPAF-II), four miniGNC antibodies whose D1 and D2 target EGFR and HER3 were grouped, including tri-miniGNC (SI-68X2, SEQ ID NO. 137, 139), tetra-miniGNC (SI-68E1, SEQ ID NO: 141, 143, and SI-68E2, SEQ ID NO: 145, 147), and penta-miniGNC (SI-68P1, SEQ ID NO: 149, 151). In the context of polyspecificity, the binding specificities of fragment 1 in the case of 4-1BB and PD-L1 changed, while the binding specificity to CD3 remained the same as D3 in this group. The expression construct encoding each of the four miniGNC antibodies was modified such that all scFv domains carried a disulfide bond. The constructs were expressed individually in the ExpiCHO system and each antibody was purified to an acceptable titer. Binding kinetics to the respective antigens were assessed using Octet. AHC sensors were used to capture miniGNC antibody at a concentration of 10 μg/mL for 180 seconds. Following a 60-second baseline step, a single antigen concentration was used in a 180-second association step. The antigens tested included 200 nM human EGFR (laboratory purified), 100 nM human CD3 (Acro CDD-H52W1), 20 nM human PD-L1 (Acro PD1-H5229), 400 nM human 4-1BB (laboratory purified), 200 nM human HER3 (Acro ER3-H5223). After association, a 420-second dissociation step was performed. The tabulated K _D values were calculated using a one-to-one binding model using ForteBio data analysis software version 11. The analyzed K D values for each miniGNC molecule with all scFv domains cross-linked, as shown in Table 5, were compared with the K D of the control mAbs against the corresponding antigens, as shown in Table 6. The binding kinetics data show comparable binding affinity of each scFv cross-linked domain to the corresponding mAb or Fc-scFv control SI-1C3 (SEQ ID 181, 183), SI-1C7 (SEQ ID 185), SI-9C21 (SEQ ID 187, 189), SI-35SF11 (SEQ ID 191), SI-3SF11 (SEQ ID 193), SI-20C14 (SEQ ID 287 and 289) (Table 6), suggesting that cross-linking of one or more scFv domains appears to have little effect on binding affinity.

To evaluate the effect of the cross-linked scFv domains on the potency of the miniGNC antibody, a T-cell directed cytotoxicity (TDCC) assay was used, and the human pancreatic cancer cell line HPAF-II (ATCC, Manassas, VA) was used as the target cells. Target cell surface expression was confirmed by flow cytometry. Serial dilutions of antibody (0 to 30 nM; dilution factor 1 to 5) were added to a white 384-well plate containing target cells and activated T cells (introduced into the plate immediately before drug administration; effector:target = 5:1) in a total volume of 50 μl. After another 72 h, 20 μl of Bright-Glo (Promega) were added to the wells and luminescence corresponding to the viability of lucifilized tumor cells was determined using a CLARIOstar plate reader. The data were fitted to a sigmoid function to calculate EC50 values. As shown in Fig. 6 and Table 5, the survival curves showed that the activity of all four miniGNC antibodies was within the pM dose range, with a trend of increasing TDCC activity from the tri-miniGNC and tetra-miniGNC antibodies towards the penta-miniGNC antibodies. This observation also indicates little effect when using cross-linked scFv domains.

Example 10. miniGNC containing a NKG2D receptor dimer as a binding domain

The increased number of binding specificities allows GNC antibodies to bind not only to T cells, but also to a subset of T cells, natural killer cells, and other types of immune cells, collectively known as fragment 1 binding domains/specificities (see Applicant's applications WO/2019/005641 and WO2019191120, which are incorporated herein in their entirety). Some fragment 1 binding specificities can be replaced by a cellular response to or recognition of target cells. For example, NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells, since its ligands are induced during cellular stress either by viral infection or by genomic stress, such as in cancer. In humans, NKG2D is expressed by NK cells, cells, and CD8+ T cells. Addition of NKG2D as a binding domain/specificity to the miniGNC class of antibodies may improve the cytotoxicity and efficacy of the antibody as a single multifunctional therapeutic agent.

In NK cells, NKG2D serves as an activation receptor that can itself trigger cytotoxicity, whereas on CD8+ T cells, NKG2D functions to transmit costimulatory signals for their activation. NKG2D forms a homodimer whose ectodomains serve for ligand binding. This feature allows NKG2D to be classified as a miniGNC binding domain, which is not based on variable sequence, and other binding domains can be added to create a class of polyspecific NKG2D-miniGNC proteins. In one miniGNC format, a single NKG2D monomer is incorporated at the D3 position of chain A and chain B to form a dimeric NKG2D receptor upon Fc dimerization. NKG2D can thus act as a receptor for a polyspecific miniGNC molecule to bind its corresponding ligand. In another miniGNC format, a tandem repeat of NKG2D was created by adding a spacer/linker (G _x S _y ) _n between individual NKG2D monomers, which homodimerizes to form a functional dimeric receptor. This tandem dimeric NKG2D structure can be located at D1, D2, D4, or D5.

As shown in Table 7, this class includes mono-NKG2D-miniGNC (SI-49R26, SEQ ID NO. 153, 155), bi-miniGNC (SI-49R27, SEQ ID NO. 157, 159), tri-miniGNC (SI-49R25, SEQ ID NO. 161, 163), tetra-miniGNC (SI-49P_X, SEQ ID NO. 165, 167) and penta-miniGNC (SI49P8, SI-49P9, SEQ ID NO. 169, 171, 177 and 179) molecules. A control penta-miniGNC, SI-49PM1 (SEQ ID NOs. 173, 175), was generated by switching the positions of D1 (αCD3) and D3 in SI-49P8, and this switching had no effect on the binding affinity for NKG2D and CD3 as analyzed by Octet. Although the binding affinity of the other fragment 1 binding domains remained stable in this class of NKG2D-miniGNC molecules, the binding affinity for NKG2D increased 2-fold. Thus, the penta-miniGNC molecule has a binding function for the NKG2D receptor, allowing for NKG2D ligand binding.

To evaluate and compare the TDCC efficiencies of NKG2D-miniGNC molecules in targeting the MDA-MB-231 breast cancer cell line, tri-, tetra-, and penta-miniGNC molecules, SI-49R25, SI-49P_X, SI-49P8, and SI-49PM1, were used. MiniGNC protein was added in serial dilutions (0 to 30 nM; dilution factor 1 to 5) to a white 384-well plate containing luciferized MDA-MB-231 cells added 24 h earlier and grown at 37°C. Activated T cells were injected immediately before the addition of miniGNC molecules (effector:target = 15:1) in a total volume of 50 μl. After incubation for an additional 72 h, 20 μl of Bright-Glo (Promega) were added to the wells and the luminescence corresponding to the viability of lucifilized tumor cells was determined using a CLARIOstar plate reader. The data were fitted to a sigmoid function to calculate the EC50 values (Fig. 7). Based on the dose-viability curves, two groups were identified: tetra- and penta-miniGNC molecules were more active than the tri-miniGNC molecule, SI-49R25. As shown in Table 7, the difference may be due to the addition of αPD-L1. However, the EC50 value (59.3 nM) of SI-49R25 should be considered relatively high. CD19, which is a pan-B cell marker, turned out to be a non-tumor antigen for the breast cancer cell line MDA-MB-231. In this regard, SI-49R25 can be considered as having two binding specificities, to CD3 and to the NKG2D ligand. Thus, the data indicate that the inclusion of the NKG2D receptor in another miniGNC antibody format contributes to TDCC efficacy. More broadly, miniGNC antibody molecules may have multiple binding specificities allowing for modulation, engagement, and delivery of an optimized immune response to target cells such as cancer.

TABLES

Table 1. Configuration, fabrication, binding affinity and potency of polyspecific minGNC molecules in targeting EGFR and/or HER3-expressing pancreatic cancer cells (BXPC3)

Protein ID D1
/KD (nM) D2
/KD (nM) D3
/KD (nM) D4
/KD (nM) D5
/KD (nM) titer (mcg/ml) EC50
(pM) penta-miniGNC SI-75P6 αCD3 αHER3 αEGFR α4-1BB αPDL-1 96.5 0.011 36.2 138 5.56 37.3 1.45 SI-75P4 αEGFR αHER3 αCD3 α4-1BBL αPDL-1 48.4 0.102 10.4 150 22.7 115 2.72 SI-75P3 αEGFR αHER3 αCD3 α4-1BB αPDL-1 39.4 1.300 8.91 158 17.4 7.51 1 SI-75P9 αEGFR αCD3 αHER3 α4-1BB αPDL-1 30 0.160 11.1 20.1 140 21.2 2.7 tetra-miniGNC SI-75E1 αEGFR αHER3 αCD3 α 4-1BB -- 30.2 5.800 8.9 185 20.3 17.8 -- SI-75E2 αEGFR αHER3 αCD3 -- αPDL-1 172.3 0.085 8.24 114 22.1 -- 1.36 tri-miniGNC SI-75X3 αEGFR αHER3 αCD3 193.5 5417 8.47 146 18.2 -- -- SI-75X16 αEGFR αHER3 αCD3* 183.5 95540 6.8 112.8 33.4 -- -- SI-75X18 αCD3* αEGFR αHER3 38.2 6090 47.3 2.72 93.75 bi-miniGNC SI-75X1 αEGFR αCD3 246.1 0.71 8.11 24 -- -- SI-75X2 αHER3 αCD3 237.7 433.8 162 27.8 -- -- SI-75X5 αHER3 αCD3* 192.9 9,095 139.2 44.4 -- --

Table 2. Effect of the position and binding affinity of the CD3 binding domain on the efficacy of penta-minGNC molecules in targeting EGFR-expressing pancreatic cancer cells (BXPC3)

Protein ID D1
/KD (nM) D2
/KD (nM) D3
/KD (nM) D4
/KD (nM) D5
/KD (nM) titer (mcg/ml) EC50
(pM) SI-68P13 αEGFR αCD19 αCD3 α4-1BB αPD-L1 35.1 0.09 5.64 4.33 25.9 14.8 1.04 SI-68P17 αCD3 αCD19 αEGFR α4-1BB αPD-L1 40 0.6 15.82 5.05 5.38 26.8 2.72 SI-68P15 αCD3** αCD19 αEGFR α4-1BB αPD-L1 58.1 0.16 22.4 2.85 2.42 17.1 0.4 SI-68P18 αCD3*** αCD19 αEGFR α4-1BB αPD-L1 26 0.19 14.46 1.35 8.18 7.51 1.00 SI-68P19 αCD3**** αCD19 αEGFR α4-1BB αPD-L1 28 0.12 16.74 3.44 4.43 21.2 0.7 SI-68P16 αCD3***** αCD19 αEGFR α4-1BB αPD-L1 72 5.5 60.6 2.55 2.41 23.3 0.5

Table 3. Effect of one or more VHH binding domains on the efficacy of polyspecific minGNC molecules in targeting BXPC3 tumor cells

Protein ID D1
/KD (nM) D2
/KD (nM) D3
/KD (nM) D4
/KD (nM) D5
/KD (nM) titer
(mcg/ml) EC50
(pM) SI-68P13
SI-75P5 αEGFR VHH αHER3 VHH αCD3 α4-1BB αPD-L1 35.1
200.5 0.09
443 23.5 4.68 26.1 23.3 3.25 SI-75P8 αEGFR VHH αHER3 VHH αCD3* αEGFR αHER3 295 967468000 6.22 0.786 44.1 6.22 0.786 SI-75X4 αEGFR VHH αHER3 VHH αCD3 -- -- 65.8 5766 51.5 7.68 26.3 -- -- SI-68P13
SI-75X17 αEGFR VHH αHER3 VHH αCD3* -- -- 35.1
330 No killing 14.8 4.58 68 -- -- SI-75X19 -- -- αCD3* αEGFR VHH αHER3 VHH 223.4 1873 64.4 20.6 10.52 SI-75X9 -- αHER3 VHH αCD3* -- -- 234 2584 -- 3.86 84.2 -- -- SI-75X11 αEGFR VHH -- αCD3* -- -- 214 564 21.6 -- 65.7 -- -- SI-75X15 -- -- αCD3* -- αHER3 VHH 161.3 27400 -- 38.08 -- 13.7 SI-75X13 -- -- αCD3* αEGFR VHH -- 165.6 4858 -- 56 34-- --

Table 4. Effect of cross-linked CD3-binding domain at position D3 on the production of polyspecific miniGNC molecules

Protein ID D1
/KD (nM) D2
/KD (nM) D3 (sewn)
/KD (nM) D4
/KD (nM) D5
/KD (nM) titer
(mcg/ml) %POI αCD20 αCD19 αCD3 α4-1BB αPD-L1 SI-38P11 7.33 1.89 5.23 (No) 14.8 1.1 80 69 SI-76PM1 6.09 3.30 3.22 (Yes) 22.43 1.47 129 75

Table 5. Comparative efficacy of polyspecific miniGNC molecules with cross-linked scFvs at all positions in targeting tumor cells

Protein ID D1 (sewn)
/KD (nM) D2 (sewn)
/KD (nM) D3
/KD (nM) D4 (sewn)
/KD (nM) D5 (sewn)
/KD (nM) titer (mcg/
ml) EC50
(pM) αEGFR* αHER3 αCD3 α4-1BB αPD-L1 HPAF-II SI-68X2 <0.001 114.4 24.3 -- -- 88.9 6.6 SI-68E1 <0.001 138.8 26.2 12.7 -- 114.8 3.6 SI-68E2 <0.001 120 28.4 -- 0.4 67 1.3 SI-68P1 <0.001 93.4 24.3 9.8 0.6 87.1 1.02 αCEA αEGFR* αCD3 MCF-7 SI-68X1 <0.001 <0.001 14.3 -- -- 69 4.2 αHER2 -- αCD3 SI-68X3 NA NA 57 NA

Table 6. Characteristics of uncrosslinked versions of each domain (D1-D5) in mAb or scFv format in relation to the corresponding antigens

Protein ID Unstitched controls Domain structure titer (mcg/ml) KD (nM) SI-1C3 D1=αEGFR* mAb 44.9 <0.001 SI-1C7 D2= αHER3 Fc-scFv 290.7 136.5 SI-9C21 D3=αCD3 mAb 252.1 26.3 SI-35FS11 D4=α4-1BB Fc-ScFv 7.67 14.9 SI-3FS11 D5=αPD-L1 Fc-ScFv 18 0.94 SI-20C14 D1= αCEA mAb NA <0.001

Table 7. Characteristics of polyspecific minGNC molecules with the NKG2D receptor dimer included in the miniGNC format and the efficacy of tri-, tetra- and penta-molecules in killing MDA-MB-231 tumor cells

Protein ID D1
/KD (nM) D2
/KD (nM) D3
/KD (nM) D4
/KD (nM) D5
/KD (nM) titer (mcg/ml) EC50
(pM) SI-49R26 -- -- NKG2D -- -- 28 n.a. -- -- 17.7- -- -- SI-49R27 αCD3 -- NKG2D -- -- 38.6 n.a. 32.2 -- 16 -- -- SI-49R25 αCD3 αCD19 NKG2D -- -- 50 59330 34.50 7.62 12.80 -- -- SI-49P_X αCD3 αCD19 NKG2D -- αPD-L1 8.8 119.5 30.45 1.31 10.4 -- 0.2 SI-49P8 αCD3 αCD19 NKG2D α4-1BB αPD-L1 62.3 570.3 36.3 2.98 24.3 7.71 1.08 SI-49PM1 NKG2D αCD19 αCD3 α4-1BB αPD-L1 30.3 946.5 24.49 5.5 30.2 2.74 2.23 SI-49P9 αCD3 αCD19 NKG2D 41BBL αPD-L1 28.9 n.a. 29.80 6.4 27.2 112 2.01

Table 8. Characteristics of bispecific miniGNC molecules with different IgG subtypes in the Fc domain

protein IgG subtype D1 D2 D3 D4 D5 titer (mcg/ml) %POI SI-75X5 IgG1 - αHER3 αCD3* - - 192.9 72.2 SI-75XM9 IgG4 - αHER3 αCD3* - - 150.5 85.6

Table 9. Annotation of binding domains by their binding specificity, domain structure, origin, and sequence identification number (SEQ ID)

target Binding domain Structure in miniGNC origin SEQ ID NO. CD20 Ritu scFv rituximab 259-262 EGFR EGFR scFv and Fab αEGFR H7 203-206 EGFR EGFR* scFv panitumumab 207-210 HER3 MM-111 scFv and Fab MM-111 255-258 CD3 αCD3 scFv and Fab 284A10 219-222 CD3 αCD3* scFv and Fab 283E3BSM 227-230 CD3 αCD3** scFv 284A10FR1 231-234 CD3 αCD3*** scFv 284A10FR2 235-238 CD3 αCD3**** scFv 284A10FR3 239-242 CD3 αCD3***** scFv 283E3FRS 291-294 PD-L1 αPD-L1 scFv PL221G5 243-246 4-1BB α4-1BB scFv 466F6 247-250 NKG2D ligand NKG2D receptor 253-254 4-1BB 41BBL ligand 251-252 EGFR αEGFR VHH VHH VHH-122 263-264 HER3 αHER3 VHH VHH VHH BCD090-M2 265-266 CD19 huBU12 scFv SI-huBU12-H4, 215-218 CEA αCEA-H1 scFv CEA-656E11 279-282 HER2 Tras scFv trastuzumab 284-285 Human IgG1 heavy chain 313 Human IgG4 light chain 314

SEQUENCE LIST

Sample ID chain SEQ ID NO. Fc ProA KO
(H435R/Y436F) VH3 ProA KO (R19S) protein DNA SI-75X5 A 1 2 + + B 3 4 SI-75X6 A 5 6 + - B 7 8 SI-75X7 A 9 10 - + B 11 12 SI-75X8 A 13 14 - - B 15 16 SI-75P6 A 17 18 + + B 19 20 SI-75P4 A 21 22 + + B 23 24 SI-75P3 A 25 26 + + B 27 28 SI-75P9 A 29 30 + + B 31 32 SI-75E1 A 33 34 + + B 35 36 SI-75E2 A 37 38 + + B 39 40 SI-75X3 A 41 42 + + B 43 44 SI-75X16 A 45 46 + + B 47 48 SI-75X18 A 49 50 + + B 51 52 SI-75X1 A 53 54 + NA B 55 56 SI-75X2 A 57 58 + + B 59 60 SI-75O2 A 61 62 + NA B 63 64 SI-75O7 A 65 66 + NA B 67 68 SI-68P13 A 69 70 + + B 71 72 SI-68P17 A 73 74 + + B 75 76 SI-68P15 A 77 78 + + B 79 80 SI-68P18 A 81 82 + + B 83 84 SI-68P19 A 85 86 + + B 87 88 SI-68P16 A 89 90 + + B 91 92 SI-75P5 A 93 94 + + B 95 96 SI-75P8 A 97 98 + + B 99 100 SI-75X4 A 101 102 + NA B 103 104 SI-75X17 A 105 106 + NA B 107 108 SI-75X19 A 109 110 + NA B 111 112 SI-75X9 A 113 114 + NA B 115 116 SI-75X11 A 117 118 + NA B 119 120 SI-75X15 A 121 122 + NA B 123 124 SI-75X13 A 125 126 + NA B 127 128 SI-38P11 A 129 130 + + B 131 132 SI-76PM1 A 133 134 + + B 135 136 SI-68X1 A 195 196 - - B 197 198 SI-68X3 A 199 200 - - B 201 202 SI-68X2 A 137 138 - - B 139 140 SI-68E1 A 141 142 - - B 143 144 SI-68E2 A 145 146 - - B 147 148 SI-68P1 A 149 150 - - B 151 152 SI-49R26 A 153 154 + NA B 155 156 SI-49R27 A 157 158 + NA B 159 160 SI-49R25 A 161 162 - - B 163 164 SI-49P_X A 165 166 - - B 167 168 SI-49P8 A 169 170 - - B 171 172 SI-49PM1 A 173 174 + + B 175 176 SI-49P9 A 177 178 - - B 179 180 SI-75XM9 A 297 298 + + B 299 300

Protein ID Format SEQ ID NO. protein protein SI-1C3HC αEGFR mAb 181 182 SI-1C3LC αEGFR mAb 183 184 SI-1C7 αHER3 Fc-scFv 185 186 SI-9C21HC αCD3 mAb 187 188 SI-9C21LC αCD3 mAb 189 190 SI-35FS11 α4-1BB Fc-scFv 191 192 SI-3FS11 αPD-L1 Fc-SCFv 193 194 SI-20C14HC αCEA mAb 656E11 287 288 SI-20C14LC αCEA mAb 656E11 289 290

Domains Variable chains SEQ ID protein DNA αEGFR VH 203 204 VL 205 206 αEGFR* VH 207 208 VL 209 210 αEGFR* cross-linked VH 211 212 VL 213 214 αCD19 VH 215 216 VL 217 218 αCD3 VH 219 220 VL 221 222 αCD3 cross-linked VH 223 224 VL 225 226 αCD3* VH 227 228 VL 229 230 αCD3** VH 231 232 VL 233 234 αCD3*** VH 235 236 VL 237 238 αCD3**** VH 239 240 VL 241 242 αPDL1 VH 243 244 VL 245 246 α41BB VH 247 248 VL 249 250 41BBL NA 251 252 NKG2D dimer NA 253 254 αHER3 VH 255 256 VL 257 258 αCD20 VH 259 260 VL 261 262 EGFR VHH VHH 263 264 HER3 VHH VHH 265 266 αPDL1 cross-linked VH 267 268 VL 269 270 α41BB crosslinked VH 271 272 VL 273 274 αHER3 cross-linked VH 275 276 VL 277 278 αCEA VH 279 280 VL 281 282 αHER2 cross-linked VH 283 284 VL 285 286 αCD3 ***** VH 291 292 VL 293 294 monomer NKG2D NA 295 296

antibody CDR by Kabat AA SEQ ID αCEA 656E11 CDR-H1 301 αCD3 283E3 (BSM/FRS) CDR-H2 302 CDR-H3 303 CDR-L1 304 CDR-L2 305 CDR-L3 306 CDR-H1 307 CDR-H2 308 CDR-H3 309 CDR-L1 310 CDR-L2 311 CDR-L3 312

>Sequence ID 1: Amino acid sequence of chain A SI-75X5

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 2: Nucleotide sequence of chain A SI-75X5

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAG TTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTT CCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACC TGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 3: Amino acid sequence of chain B SI-75X5

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSAR DSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 4: Nucleotide sequence of chain B SI-75X5

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAG GTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAG GACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACC CAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGG GATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGC CTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACC CTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 5: Amino acid sequence of chain A SI-75X6

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 6: Nucleotide sequence of chain A SI-75X6

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAG TTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTT CCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACC TGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 7: Amino acid sequence of chain B of SI-75X6

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSAR DSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 8: Nucleotide sequence of chain B SI-75X6

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAG GTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAG GACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACC CAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGG GATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGC CTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACC CTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 9: Amino acid sequence of chain A SI-75X7

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 10: Nucleotide sequence of chain A SI-75X7

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAG TTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTT CCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACC TGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 11: Amino acid sequence of chain B of SI-75X7

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSAR DSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 12: Amino acid sequence of chain B of SI-75X7

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAG GTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAG GACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACC CAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGG GATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGC CTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACC CTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 13: Amino acid sequence of chain A SI-75X8

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 14: Chain A Nucleotide Acid Sequence SI-75X8

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAG TTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTT CCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACC TGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 15: Amino acid sequence of chain B of SI-75X8

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSAR DSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 16: Nucleotide sequence of chain B of SI-75X8

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAG GTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAG GACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACC CAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGG GATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGC CTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACC CTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 17: Amino acid sequence of chain A of SI-75P6

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGG GSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNI WGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALT YYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS CDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMT QSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 18: Nucleotide sequence of chain A SI-75P6

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGG TTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGAAGGGGCTGGAGTGGATCGGA GTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTG GGGCCAGGGAACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCA CCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCT ACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAA CTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTT GTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGA CGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAA GGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCG ACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACG CAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAG GTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCT GGGGGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTA ACGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT

>Sequence ID 19: Amino acid sequence of chain B of SI-75P6

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGG SGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWG RGTLVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPG TKLTVLRTVAAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTC PPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTL SASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 20: Nucleotide sequence of chain B SI-75P6 CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTG TCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTT CTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAA CATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGT GGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAA CCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAA AGCTGACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGT CACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGG TGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAG CAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCA GCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACT TTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGC AATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 21: Amino acid sequence of chain A of SI-75P4

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNY GVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWA KGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS CDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAV EWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRV VAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGSTGSGSKPGSGEGSTKGREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLA GVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGGGGSGGGGSREGPELSPDDPAGLLDLR QGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGL

>Sequence ID 22: Nucleotide sequence of chain A SI-75P4

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCC AGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATC AGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGG AGGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGG AGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATA ATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGA CTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAG CCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGA AAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCT ATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCG GCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTAC TCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACA TGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTAC CGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAA GGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAG TGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGG GAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCCGAGAGGGCCC CGAGCTGTCTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGTGGCTCAGAATGTTCTGCTCATTGATGGACCACTCTCTTGGTATAGTGACCCCGG TCTGGCCGGGGTGAGTCTGACCGGCGGGCTCTCTTATAAAGAGGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTTATTACGTTTTTTTTCAGCTGGAGCTCAGGCGCGTGGTGGC CGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGCTGCAGGTGCTGCCGCACTGGCTTTAACTGTTGACCTCCCTCCGCCTCTTCTGAAGCTAGAA ACAGCGCTTTCGGCTTCCAAGGGCGCCTGCTGCACCTGAGCGCAGGCCAGCGCTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACACGCTTGGCAGCTCACACAGGGTGCCACGG TTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACGAGAAGGGCCAGAGTTAAGTC CAGATGACCCTGCTGGGCTTTTGGACCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGCCCCCTGAGTTGGTACAGCGATCCCGGGCTGGCAGGCG TGTCACTTACAGGGGGCCTCTCTTACAAGGAAGACACCAAGGAGTTAGTGGTCGCTAAGGCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTGTGGCAGGAGAGGGT AGCGGCAGCGTGTCTTTAGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACCGTGGATCTCCCCCCAGCCTCATCTGAAGCTAGGAACAGTGCATTT GGCTTTCAGGGACGCTTGCTGCACCTCTCCGCTGGACAGAGGCTGGGCGTGCACCTTCACACAGAGGCCCGTGCCAGGCATGCATGGCAGCTCACTCAGGGGGCAACAGTGCTGGGTCTC TTCCGCGTGACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGTGAGGGGCCAGAACTGTCCCCCGATGACCCAGCCGGACTGCTCGATCTCAGACAG GGCATGTTCGCTCAGCTTGTAGCCCAAAATGTCCTCCTGATTGACGGCCCTTTGAGCTGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAGGCCTCTCCTACAAGGAAGAC ACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAGCTGCGGAGAGTTGTGGCCGGGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCAGCCC CTGCGCAGCGCCGCTGGAGCCGCCGCCCTTGCTCTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTCAAGGACGTCTCCTGCACTTGTCCGCAGGA CAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCTTGGCAGCTTACCCAGGGAGCCACGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTGA

>Sequence ID 23: Amino acid sequence of chain B of SI-75P4

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGS GGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRG TLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFG GGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 24: Nucleotide sequence of chain B of SI-75P4

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGT CTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACA TAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGC ACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCC CTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCA GGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACA CATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAAC CACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTC TATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTT ACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGT GCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 25: Amino acid sequence of chain A of SI-75P3

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGG GSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGT LVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAI TSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK THTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQ PREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQ SPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 26: Nucleotide sequence of chain A SI-75P3

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGAC CGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGA GGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCA GGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTC TTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGC TGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTAC TAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAG CCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGT CTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTT CTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGG GGGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAA CGTCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT

>Sequence ID 27: Amino acid sequence of chain B of SI-75P3

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGS GGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRG TLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFG GGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 28: Nucleotide sequence of chain B of SI-75P3

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGT CTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACA TAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGC ACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCC CTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCA GGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACA CATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAAC CACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTC TATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTT ACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGT GCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 29: Amino acid sequence of chain A of SI-75P9

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGG GSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGT LVTVSSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGY FDLWGRGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQP REPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQS PSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSG GGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

Sequence ID 30: Nucleotide sequence of chain A of SI-75P9 GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGAC CGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGA GGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCA GGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACT CTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAGGTGCAGCTGCAGGAGAGTGGAGGAGGCCTGGTGAAGCCTGGAGGCAGCCTGCGGCTGTCCTGTGCTGCCTCTGGCTTCACCTTCCTCCTACTGGATGAGCTGGGTGCGCCAGGCCCCAGGCAAGGGC CTGGAGTGGGTGGCCAACATCAACAGAGATGGCTCTGCCTCCTACTATGTGGACTCTGTGAAAGGCCGCTTCACCATCTCCAGAGATGATGCCAAGAACAGCCTGTACCTGCAGATGAACAGCCTGAGAGCTGAGGACACAGCTGTGTACTACTGTGCCAGAGACCGAGGTGTGGGCTAC TTTGACCTGTGGGGCAGAGGCACCCTGGTGACTGTGTCCTCTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTG ACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGG TGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCC GAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCT TCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCTCC TAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGG AACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGG TGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGT CTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 31: Amino acid sequence of chain B of SI-75P9

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGGG SGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIW GQGTLVTVSSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVI FGGGTKVTVLRTPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTKPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECSGGDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPR EPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPS TLSASVGDRVTTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGS EVQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 32: Nucleotide sequence of chain B of SI-75P9

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGT TCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAG TCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGG GGCCAGGGAACCCTGGTCACCGTGTCCTCAGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAGAGTGCCCTGACCCAGCCAGCCTCTGTCTCTGGCAGCCCAGGCCAGTCCATCACCATCTCCTGCACAGGCACCTCCAGTGATGTGGGAGGCTACAACTTTGTGTCCTGGTACCAGCAGC ACCCAGGCAAGGCCCCCAAGCTCATGATCTATGATGTGTCTGACAGACCCTCTGGAGTCTCTGACAGATTCTCTGGCTCCAAGAGTGGCAACACAGCCTCCCTCATCATCTCTGGCCTGCAGGCTGATGATGAAGCTGACTACTACTGCTCCTCCTATGGCTCCTCCTCCACCCATGTCATC TTTGGAGGAGGCACCAAGGTCACTGTGCTGCGTACGCCCAAGGCCAACCCCACCGTGACCCTGTTCCCCCCAAGCAGCGAGGAACTGCAGCCAACAAGGCCACCCTCGTGTGCCTGATCAGCGACTTCTACCCTGGCGCCGTGACCGTGGCCTGGAAGGCCGATGGATCTCCCGTGAAGGC CGGCGTGGAAACCACCAAGCCCAGCAAGCAGAGCAACAACAAATACGCCGCCAGCTCCTACCTGAGCCTGACCCCCCGAGCAGTGGAAGTCCCACCGGTCCTACAGCTGCCAGGTCACACACGAAGGCAGCACCGTGGAAAAGACAGTGGCCCCCACCGAGTGCAGCGGAGGCGACAAAACTC ACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGT GCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAG AACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTC CTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTAC GCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAG TTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGA AGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACG ATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCT

>Sequence ID 33: Amino acid sequence of chain A of SI-75E1

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGG GSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGT LVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAI TSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK THTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQ PREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQ SPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 34: Nucleotide sequence of chain A of SI-75E1

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGAC CGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAG GGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAG GTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCT TGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCT GGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACT AGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAA CTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCC CCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTC CTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCT CCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCT GGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGGG GTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGT CTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 35: Amino acid sequence of chain B of SI-75E1

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 36: Nucleotide sequence of chain B of SI-75E1

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATT ACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGA GTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGA CACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAG TCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAA GCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTA TTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGT GCCTGCTCAACAACTTCTACCCCAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCAC CCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTG CCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGA CCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 37: Amino acid sequence of chain A of SI-75E2

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLG VIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCA RDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 38: Nucleotide sequence of chain A of SI-75E2

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGC CAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAG CAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTG TTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACT ATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGG AGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGG TCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGA GACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGC ACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTG TCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACC CAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGA ATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGAC CAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 39: Amino acid sequence of chain B of SI-75E2

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGS GGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRG TLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFG GGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 40: Nucleotide sequence of chain B of SI-75E2

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGT CTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACA TAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGC ACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCC CTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCA GGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACA CATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAAC CACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTC TATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCT CTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTT ACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGT GCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 41: Amino acid sequence of chain A SI-75×3

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLG VIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCA RDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 42: Nucleotide sequence of chain A SI-75X3

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGC CAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAG CAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTG TTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACT ATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGG AGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGG TCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGA GACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGC ACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTG TCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACC CAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGA ATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGAC CAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 43: Amino acid sequence of chain B of SI-75X3

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 44: Nucleotide sequence of chain B of SI-75X3

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATT ACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGA GTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGA CACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAG TCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAA GCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTA TTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGT GCCTGCTCAACAACTTCTACCCCAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCAC CCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTG CCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGA CCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 45: Amino acid sequence of chain A SI-75X16

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEW LGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYC ARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDP EVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 46: Nucleotide sequence of chain A SI-75X16

GAGATCGTGCTGACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCACCTTCAGCTGTAGAGCCTCTCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCC TCGGCTGCTGATTAAGTACGCCTCCGAGTCCATCAGCGGCATCCCTGACAGATTCTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACCATCTCCTCCGTGCAGTCCGAGGATTTCGCCGTGTACTACT GCCAGCAGAACAACAACTGGCCCACCACCTTTGGACCCGGCACCAAGCTGACAGTTCTTGGCGGCGGAGGATCTGGCGGAGGTGGAAGCGGAGGCGGAGGAAGCGGTGGCGGCGGATCTCAAGTTCAGTTG CAGCAGTCTGGCCCTGGCCTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTCTCCCTGACCAATTACGGCGTGCACTGGATCAGACAGGCCCCTGGCAAAGGACTGGAATGGCT GGGAGTGATTTGGAGCGGCGGCAACACCGACTACAAACACCCCTTTCACCAGCCGGTTCACCATCACCAAGGACAACTCCAAGAACCAGGTGTACTTCAAGCTGCGGAGCGTGCGGGCTGATGACACCGCCA TCTACTACTGTGCTCGGGCCCTGACCTACTACGACTACGAGTTTGCTTACTGGGGCCAGGGCACCCTGGTCACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAA AGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGT TATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTG CCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCC CTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGT GGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCT GCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAA GTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGG GAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCA AGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCC TTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 47: Amino acid sequence of chain B of SI-75X16

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSAR DSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 48: Nucleotide sequence of chain B SI-75X16

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTAT TACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAG GTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTG GAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAG GACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACC CAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTT ATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGG GATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGC CTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACC CTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTG ACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGC TCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 49: Amino acid sequence of chain A SI-75X18

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPP SRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITK DNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVL

>Sequence ID 50: Nucleotide sequence of chain A SI-75X18

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGG TCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATA CCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACC TCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCT CTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGA CCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTG TCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCA CCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCT CCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTG CTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCT GAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAAGTTCAGTTGCAGCAGTCTGGCCCTGGCCTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTCTCCC TGACCAATTACGGCGTGCACTGGATCAGACAGGCCCCTGGCAAAGGACTGGAATGGCTGGGAGTGATTTGGAGCGGCGGCAACACCGACTACAACACCCCTTTCACCAGCCGGTTCACCATCACCAAGGAC AACTCCAAGAACCAGGTGTACTTCAAGCTGCGGAGCGTGCGGGCTGATGACACCGCCATCTACTACTGTGCTCGGGCCCTGACCTACTACGACTACGAGTTTGCTTACTGGGGCCAGGGCACCCTGGTCAC AGTTTCTTCTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAGATCGTGCTGACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCACCT TCAGCTGTAGAGCCTCTCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCCTCGGCTGCTGATTAAGTACGCCTCCGAGTCCATCAGCGGCATCCCTGACAGATTCTCCGGC TCTGGCTCTGGCACCGAGTTTACCCTGACCATCTCCTCCGTGCAGTCCGAGGATTTCGCCGTGTACTACTGCCAGCAGAACAACAACTGGCCCACCACCTTTGGACCCGGCACCAAGCTGACCGTGCTGTGA

>Sequence ID 51: Amino acid sequence of chain B SI-75X18

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDS TYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCV VVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYT LPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFT ISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL

>Sequence ID 52: Nucleotide sequence of chain B SI-75X18

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAA ACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGGGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCT ACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGC ACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACC TACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGG AGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGG TGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACT GTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTG CCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCC TCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGA AGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGA TTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATC TCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGT CACCGTGTCTAGCGGTGGAGGCGGTTCAGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCCAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAA CCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAG TCTGGCAACACGGCCTCCCTGATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTATAA

>Sequence ID 53: Amino acid sequence of chain A SI-75X1

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLG VIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCA RDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 54: Nucleotide sequence of chain A SI-75X1

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGC CAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAG CAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTG TTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACT ATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGG AGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGG TCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGA GACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGC ACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTG TCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGC CCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACC CAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGA ATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGAC CAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 55: Amino acid sequence of chain B of SI-75X1

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDK THTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 56: Nucleotide sequence of chain B of SI-75X1

GACGTGGTCATGACACAGAGCCCTTCCACACTGTCTGCCTCCGTGGGCGATAGAGTGACCATCAACTGTCAGGCCTCCGAGTCCATCTCCTCTTGGCTGGCTTGGTATCAGCAGAAGCCTGGCAAGGCCCCTAAGCTGCTGATCTACGAGGCTTCCAAGCTGGCCTCT GGCGTGCCCTCTAGATTTTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACAATCTCCAGCCTGCAGCCTGACGACTTCGCCACCTACTACTGCCAAGGCTACTTCTACTTCATCTCCCGGACCTACGTGAACTCCTTTCGGCGGAGGCACCAAGGTGGAGATCAAG CGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTG ACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACC CACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTG GATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACC ATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTAC AAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 57: Amino acid sequence of chain A SI-75X2

EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQ GTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 58: Nucleotide sequence of chain A SI-75X2

GAGGTGCAGCTGGTTGAATCTGGCGGAGGATTGGTTCAGCCTGGCGGCTCTCTGAGACTGTCTTGTGCCGCTTCTGGCTTCACCATCTCCACCAACGCCATGTCCTGGGTCCGACAGGCTCCTGGCAAAGGCCTGGAATGGATCGGCGTGATCACCGGCAGAGATATT ACCTACTACGCCTCCTGGGCCAAGGGCAGATTCACCATCAGCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAGAGATGGCGGCAGCAGCGCCATCACCTCCAACAATATTTGGGGCCAGG GCACCCTGGTCACTGTGTCCTCTGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGG AGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAG ACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTAT GTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGA CCATCTTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 59: Amino acid sequence of chain B of SI-75X2

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDE LTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 60: Nucleotide sequence of chain B of SI-75X2

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATT ACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGG TGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGA GTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGA CACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAG TCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAA GCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTA TTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGT GCCTGCTCAACAACTTCTACCCCAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCAC CCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTG CCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGAC CCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTG AATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGGCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGA CCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTC CTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 61: Amino acid sequence of chain A of SI-75O2

EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQ GTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 62: Nucleotide sequence of chain A of SI-75O2

GAGGTGCAGCTGGTTGAATCTGGCGGAGGATTGGTTCAGCCTGGCGGCTCTCTGAGACTGTCTTGTGCCGCTTCTGGCTTCACCATCTCCACCAACGCCATGTCCTGGGTCCGACAGGCTCCTGGCAAAGGCCTGGAATGGATCGGCGTGATCACCGGCAGAGATATT ACCTACTACGCCTCCTGGGCCAAGGGCAGATTCACCATCAGCCGGGACAACTCCAAGAACACCCTGTACCTGCAGATGAACTCCCTGAGAGCCGAGGACACCGCCGTGTACTACTGTGCTAGAGATGGCGGCAGCAGCGCCATCACCTCCAACAATATTTGGGGCCAGG GCACCCTGGTCACTGTGTCCTCTGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGG AGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAG ACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTAT GTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGA CCATCTTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 63: Amino acid sequence of chain B of SI-75O2

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEI KRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDK THTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 64: Nucleotide sequence of chain B of SI-75O2

GACGTGGTCATGACACAGAGCCCTTCCACACTGTCTGCCTCCGTGGGCGATAGAGTGACCATCAACTGTCAGGCCTCCGAGTCCATCTCCTCTTGGCTGGCTTGGTATCAGCAGAAGCCTGGCAAGGCCCCTAAGCTGCTGATCTACGAGGCTTCCAAGCTGGCCTCT GGCGTGCCCTCTAGATTTTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACAATCTCCAGCCTGCAGCCTGACGACTTCGCCACCTACTACTGCCAAGGCTACTTCTACTTCATCTCCCGGACCTACGTGAACTCCTTTCGGCGGAGGCACCAAGGTGGAGATCAAG CGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTG ACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACC CACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTG GATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACC ATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTAC AAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 65: Amino acid sequence of chain A SI-75O7

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 66: Nucleotide sequence of chain A SI-75O7

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAG TTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTT CCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACC TGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGAT GGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTA CAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGA

>Sequence ID 67: Amino acid sequence of chain B of SI-75O7

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 68: Nucleotide sequence of chain B of SI-75O7

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCT TGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTA CGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCAC ACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGA TGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTAC AAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 69: Amino acid sequence of chain A SI-68P13

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVLGGGGSGGGGSGGG GSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGT LVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAI TSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK THTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQ PREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQ SPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 70: Nucleotide sequence of chain A SI-68P13

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGAC CGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAG GGTCCGGCGGTGGAGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAG GTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCT TGTAACAGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCT GGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACT AGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCC CTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAA CTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGG AGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCC CCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTC CTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCT CCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCT GGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGGG GTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGT CTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 71: Amino acid sequence of chain B of SI-68P13

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTL VTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGG GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 72: Nucleotide sequence of chain B of SI-68P13

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCT TCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTC CGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGG GACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCG TCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCT CCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGG ACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGA GTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCT CAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTAC TTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTG CAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 73: Amino acid sequence of chain A SI-68P17

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGG GSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNI WGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALT YYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS CDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMT QSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 74: Nucleotide sequence of chain A SI-68P17

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAA GGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGT TCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAG TCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGG GGCCAGGGAACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCAC CCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTAC TACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACT CAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACG GCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGG CAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAG TCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTT CTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACG TCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 75: Amino acid sequence of chain B of SI-68P17

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGT LVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLS ASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEV QLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 76: Nucleotide sequence of chain B of SI-68P17

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGC TTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGG TCCGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGG TGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACT CTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTG ACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGA CAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGC CTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTT GACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCA ATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 77: Amino acid sequence of chain A SI-68P15

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGQGTKLTVLGGGGSGGG GSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNI WGQGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALT YYDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKS CDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMT QSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 78: Nucleotide sequence of chain A SI-68P15

GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTCCGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGTCAAAATTGGCGTCTGGTGTCCCATCTA GGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGTCTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTTCGGCCAAGGAACAAAGTTGACTGTTCTTGGTGGCGGAGGCAGTGGTGGCGGGGGC AGCGGAGGTGGTGGTTCAGGGGGTGGTGGGAGCGAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGCGCCGCTAGTGGCTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGTCGGCG TCATCACCGGCAGGGACATTACATACTATGCGAGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTTCAAAGAATACCGTTTACCTTCAAATGAATAGCTTGAGGGCGGAAGACACAGCTGTGTATTACTGCGCGAGGGATGGAGGTAGTTCCGCCATAACTTCCAACAACATATGG GGACAAGGCACGCTGGTTACTGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCAC CCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTAC TACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACT CAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGT GACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACG GCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGG CAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAG TCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTT CTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACG TCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 79: Amino acid sequence of chain B of SI-68P15

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGT LVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLS ASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEV QLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 80: Nucleotide sequence of chain B of SI-68P15

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGC TTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGG TCCGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGG TGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACT CTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTG ACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGA CAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGC CTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTT GACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCA ATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 81: Amino acid sequence of chain A SI-68P18

DVQMTQSPSTLSATVGQRVTINCQASESISSWLAWYQQKPGQPPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQSDDFATYYCQGYFYFISRTYVNSFGGGTRVEIKGGGGSGGG GSGGGGSGGGGSQQLLESGGRLIKPGATLRLTCKTSGFTISTNAMSWVRQPPGKGLEWIGVITGRDITYYASWAKGRFTISKTSINTVFLQMRSLRAEDTAVYYCARDGGSSAITSNNIWG RGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTY YDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC DKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMT QSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 82: Nucleotide sequence of chain A SI-68P18

GATGTGCAGATGACCCAGAGCCCGAGCACCCTGAGCGCGACCGTGGGCCAGCGCGTGACCATTAACTGCCAGGCGAGCGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGCCGCCGAAACTGCTGATTTATGAAGCGAGCAAACTGGCGAGCGGCGTGCCGAGCC GCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGCCTGCAGAGCGATGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTTTGGCGGCGGCACCCGCGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGG TTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGCAGCTGCTGGAAAGCGGCGGCCGCCTGATTAAACCGGGCGCGACCCTGCGCCTGACCTGCAAAACCAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGCCGCCGGGCAAAGGCCTGGAATGGATTGGCGTG ATTACCGGCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCATTAACACCGTGTTTCTGCAGATGCGCAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTACCAGCAACAACATTTGGGGCC GCGGCACCCTGGTGACCGTGAGCAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGG CAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTAC GATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAG GCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCG TGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGT CTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTC TGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACG TCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 83: Amino acid sequence of chain B of SI-68P18

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGT LVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLS ASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEV QLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 84: Nucleotide sequence of chain B of SI-68P18

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGC TTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGG TCCGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGG TGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACT CTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTG ACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGA CAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGC CTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTT GACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCA ATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 85: Amino acid sequence of chain A SI-68P19

DVVMTQSPSSLSASVGDRVTISCQASESISSWLAWYQQKPGQAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLEPEDFATYYCQGYFYFISRTYVNSFGGGTKVEIKGGGGSGGG GSGGGGSGGGGSQQLVESGGGLVKPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISKTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWG QGTLVTVSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTY YDYEFAYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC DKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAK GQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMT QSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 86: Nucleotide sequence of chain A SI-68P19

GATGTGGTGATGACCCAGAGCCCGAGCAGCCTGAGCGCGAGCGTGGGCGATCGCGTGACCATTAGCTGCCAGGCGAGCGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGGCGCCGAAACTGCTGATTTATGAAGCGAGCAAACTGGCGAGCGGCGTGCCGAGCC GCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGCCTGGAACCGGAAGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTTTGGCGGCGGCACCAAAGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGG TTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGAAACCGGGCGGCAGCCTGCGCCTGAGCTGCGCGGCGAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGGCGCCGGGCAAAGGCCTGGAATGGGTGGGCGTG ATTACCGGCCGCGATATTACCTATTATGCGAGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCAAAAACACCGTGTATCTGCAGATGAACAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTACCAGCAACAACATTTGGGGCC AGGGCACCCTGGTGACCGTGAGCAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGG CAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTAC GATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAG GCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCG TGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCA GCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGT CTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTC TGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGG GGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACG TCTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 87: Amino acid sequence of chain B of SI-68P19

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGT LVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLS ASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEV QLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 88: Nucleotide sequence of chain B of SI-68P19

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGC TTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGG TCCGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGG TGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACT CTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTG ACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGA CAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGC CTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTT GACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCA ATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 89: Amino acid sequence of chain A SI-68P16

DPVLTQSPSSLSSASVGDRVTISCQSSQSVAKNNNLAWFQQKPGQAPKLLIYSASTLAAGVPSRFSGSGSGTDFTLTISSVQPEDFATYYCSARDSGNIQSFGGGTKVEIKGGGGSGGGG SGGGGSGGGGSQQLVESGGGLVKPGGSLRLSCAASGIDLSSNAIGWVRQAPGKGLEWVGVIFGSGNTYYASWAKGRFTISRSKNTVYLQMNSLRAEDTAVYYCARGGYSSDIWGQGTLVT VSSGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEF AYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQP REPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQS PSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSG GGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 90: Nucleotide sequence of chain A SI-68P16

GATCCAGTTCTGACACAAAGTCCATCCAGCCTGTCTGCCTCAGTCGGCGACAGAGTGACCATCAGTTGCCAGAGCTCACAGTCTGTGGCTAAGAACAACAACTTGGCGTGGTTCCAACAGAAACCTGGACAGGCTCCGAAATTGCTGATCTATTCTGCTTCCACGCTTGCTGCTGGTGT TCCTTCCCGCTTTTCAGGTAGTGGTAGCGGGACAGACTTCACTTTGACTATAAGCAGCGTGCAGCCTGAAGATTTTGCGACCTACTATTGTTCTGCTAGAGACAGTGGAAATATTCAGTCCTTTGGGGGGGGAACGAAGGTCGAAATAAAGGGCGGCGGAGGGTCTGGTGGGGGTGGCAG TGGTGGTGGAGGAAGTGGTGGCGGTGGTTCCCAACAGTTGGTTGAGTCTGGTGGCGGTCTCGTTAAGCCTGGAGGGTCCCTTCGGCTTAGTTGTGCGGCCTCTGGGATCGACCTGTCTAGCAACGCTATAGGATGGGTACGGCAAGCTCCGGGCAAAGGCCTTGAGTGGGTCGGCGTTA TTTTTGGGAGCGGTAATACGTACTACGCCAGCTGGGCAAAAGGTAGGTTCACTATCAGTCGATCAAAGAACACGGTATATCTTCAGATGAACAGTCTCCGGGCGGAGGACACCGCGGTTTATTATTGCGCAAGGGGGGGATACTCCTCAGACATATGGGGCCAAGGTACTTTGGTGACGG TCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGG CTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATAACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCG TATTGGGGGCAAGGGACTCTTGTAACAGTCTCCAGTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGC GGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACA TGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGA ACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT TCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCTCCTA GTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGA ACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGT GGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGTC TATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 91: Amino acid sequence of chain B of SI-68P16

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGT LVTVSSGGGGSGGGGSEIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPP CPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQV YTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLS ASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEV QLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 92: Nucleotide sequence of chain B of SI-68P16

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGC TTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGG TCCGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGG TGGGACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACT CTCGTCACGGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCC AGGCTTTTGATTAAGTATGCAAGTGAGTCTATTTCCGGTATCCCTGACCGCTTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTG ACCGTTTTACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGT GCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGA CAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGT ACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCA AGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGC CTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTT GACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCA ATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGC AAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 93: Amino acid sequence of chain A of SI-75P5

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVL APGNVYSYWGQGTQVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKN TLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVE VHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQ QKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGSGGGGSEVQLVESGGGL VQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 94: Nucleotide sequence of chain A SI-75P5

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGT GGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTG GCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAG CCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAAC ACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCT TCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGA CTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGC ACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGG TGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCAT CTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGA ACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTC TCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACA AAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGGACGCTGCCACGTATTATTGCCAGTCC ACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGT TCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGTCTATTACGCCTCATCCGCGCGGG GGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 95: Amino acid sequence of chain B of SI-75P5

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSS WPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLT ISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVH NAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENN YKTTPPVLDSDGSFFLYSKLTVDKSRWQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKP GKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSEVQLLESGGGLVQPGG SLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 96: Nucleotide sequence of chain B of SI-75P5

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGG CAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTG GCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAA TTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCAT CAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATG AGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCA GCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTG AAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATA ATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAA GCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTAC AAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCT CCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGT AAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGG GGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGC CTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATGCAAACTGGGCGAAAGGGCGCTTC ACAATCTCCAGGGACAACTCAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 97: Amino acid sequence of chain A of SI-75P8

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLV LAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTS TVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSL SSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHN AKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENN YKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIR QAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSSGGGGSGGGGSGGGGSGGGGSEIV LTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVL

>Sequence ID 98: Nucleotide sequence of chain A SI-75P8

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTG TGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTG CTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGT AAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCT ACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCC TCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTG TCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCT GCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATG CCAAGACCAAGCCCAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCAAGG CCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACT ACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCC TGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAAGTTCAGTTGCAGCAGTCTGGCCCTGGCCTGGTCAAGCCTTCTGAGACACTGTCCATCACCTGTACCGTGTCCGGCTTCTCCCTGACCAATTACGGCGTGCACTGGATCAGACA GGCCCCTGGCAAAGGACTGGAATGGCTGGGAGTGATTTGGAGCGGCGGCAACACCGACTACAACACCCCTTTCACCAGCCGGTTCACCATCACCAAGGACAACTCCAAGAACCAGGTGTACTTCAAGCTGCGGAGCGTGCGGGCTGATGACACCGC CATCTACTACTGTGCTCGGGCCCTGACCTACTACGACTACGAGTTTGCTTACTGGGGCCAGGGCACCCTGGTCACAGTTTCTTCTGGTGGTGGTGGTTCAGGCGGGGGGGGTTCCGGCGGAGGCGGTTCTGGGGGTGGAGGTTCCGAGATCGTGCT GACCCAGTCTCCTTCCACACTGTCTGTGTCTCCCGGCGAGAGAGCCACCTTCAGCTGTAGAGCCTCTCAGTCCATCGGCACCAACATCCACTGGTATCAGCAGAAGCCCGGCAAGCCTCCTCGGCTGCTGATTAAGTACGCCTCCGAGTCCATCAG CGGCATCCCTGACAGATTCTCCGGCTCTGGCTCTGGCACCGAGTTTACCCTGACCATCTCCTCCGTGCAGTCCGAGGATTTCGCCGTGTACTACTGCCAGCAGAACAACAACTGGCCCACCACCTTTGGACCCGGCACCAAGCTGACCGTGCTGTGA

>Sequence ID 99: Amino acid sequence of chain B of SI-75P8

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGS SWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQ FTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTY SLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQ PENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMS WVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSGGGGSQSALTQ PASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL

>Sequence ID 100: Nucleotide sequence of chain B of SI-75P8

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGA GGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCA GCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAAC AATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAA TTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTG ATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAG CCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGACAAGACCCACACCTGCCCTCCCTGCCCA GCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGG AAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGAC CATCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCA GAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGA GCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTG GGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCT GAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCTAGCGGTGGAGGCGGTTCAGGCGGAGGTGGTTCCGGCGGTGGCGGCTCCCAGTCTGCCCTGACTCAGCCTG CCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGT GTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTATAA

>Sequence ID 101: Amino acid sequence of chain A SI-75X4

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSEVQLVESGGGL VQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMSSLRSEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPV TVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 102: Nucleotide sequence of chain A SI-75X4

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGAC AATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGAGGAGGAGGCTCTGGAGGAGGAGGCAGTGAGGTGCAGCTGGTGGAGAGTGGAGGAGGCCTGGTG CAGCCTGGAGGCAGCCTGCGGCTGTCCTGTGCTGCCTCTGGCTTCACCATCTCCACCAATGCCATGTCCTGGGTGCGCCAGGCCCCTGGCAAGGGCCTGGAGTGGATTGGAGTCATCACTGGCAGAGACATCACCTACTATGCCTCCTGGGCCAAAGGCCGCTTCACCATCTCCAGAGACAACAGCAAGAACACCCTGTACCTGCAGATGAGCAGCCTG CGCAGTGAGGACACAGCTGTGTACTACTGTGCCCGAGATGGAGGCAGCAGTGCCATCACCTCCAACAACATCTGGGGCCAGGGCACCCTGGTCACTGTGTCCTCTGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACT GTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACCTGCCCTCCC TGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGA GTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCC AGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 103: Amino acid sequence of chain B of SI-75X4

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDVVMTQSPS TLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKV DNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 104: Nucleotide sequence of chain B of SI-75X4

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGAC AATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGCGGAGGAGGAGGCTCTGGAGGAGGAGGCAGTGATGTGGTGATGACCCAGAGCCCCTCC ACCCTGTCTGCCTCTGTGGGAGACAGAGTGACCATCAACTGCCAGGCCAGTGAGAGCATCTCCTCCTGGCTGGCCTGGTACCAGCAGAAGCCAGGCAAGGCCCCCAAGCTGCTCATCTATGAAGCCTCCAAGCTGGCCTCTGGAGTGCCCTCCCGCTTCTCTGGCTCTGGCTCTGGCACAGAGTTCACCCTGACCATCTCCAGCCTGCAGCCAGATGAC TTTGCCACCTACTACTGCCAGGCTACTTCTACTTCATCTCCAGGACCTATGTGAACAGCTTTGGAGGAGGCACCAAGGTGGAGATCAAGCGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGG ACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTC CCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCG AGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCC CAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 105: Amino acid sequence of chain A SI-75X17

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGR LVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRV VSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 106: Nucleotide sequence of chain A SI-75X17

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGA GACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGA CTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCC CTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGA ACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAG CCCCAGAGGCTGCTGGAGGCCCCTCTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGCAGTACAACTCCACCTACCGAGTGGT GTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAG TGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 107: Amino acid sequence of chain B of SI-75X17

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSP SSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 108: Nucleotide sequence of chain B of SI-75X17

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGA CAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAG TAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAA GTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAAACTTCTACCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACA ATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCC TGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGA GTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCC AGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 109: Amino acid sequence of chain A SI-75X19

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKD YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHY TQKSLSLSPGGGGGSGGGGSEVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS

>Sequence ID 110: Nucleotide sequence of chain A SI-75X19

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGC ACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGAC TACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGT GACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAG AAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCC TGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACAC CCAGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCGAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTG GAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTGTCTAGCTGA

>Sequence ID 111: Amino acid sequence of chain B of SI-75X19

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFT QKSLSLSPGGGGGSGGGGSQVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS

>Sequence ID 112: Nucleotide sequence of chain B of SI-75X19

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATT TACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGA AGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAG GAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAG AAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTG TGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAG AAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGC CTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTGTCTAGCTGA

>Sequence ID 113: Amino acid sequence of chain A SI-75X9

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 114: Nucleotide sequence of chain A SI-75X9

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCA ATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGT TTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTC CCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCT GCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGG AGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATC TCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACA AGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 115: Amino acid sequence of chain B of SI-75X9

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSSGGGGSGGGGSDPQLTQSP SSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTY RVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 116: Nucleotide sequence of chain B of SI-75X9

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGA CAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGACCCAGTCCCCTAG TAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAA GTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAAACTTCTACCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACA ATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCACACCTGCCCTCCC TGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGA GTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCC AGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 117: Amino acid sequence of chain A SI-75X11

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSSGGGGSGGGGSQVQLQESGGR LVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRV VSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 118: Nucleotide sequence of chain A SI-75X11

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGA GACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCACAAGTGCAGTTGCAAGAAAGTGGTGGTAGA CTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCC CTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGA ACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCTGCCCTCCCTGCCCAG CCCCAGAGGCTGCTGGAGGCCCCTCTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGCAGTACAACTCCACCTACCGAGTGGT GTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAG TGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 119: Amino acid sequence of chain B of SI-75X11

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 120: Nucleotide sequence of chain B SI-75X11

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCT TGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTA CGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCAC ACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGA TGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTAC AAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 121: Amino acid sequence of chain A SI-75X15

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 122: Nucleotide sequence of chain A SI-75X15

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCA ATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGT TTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGACTACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTC CCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGTGACAAGACCCACACCT GCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGG AGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATC TCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACA AGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 123: Amino acid sequence of chain B of SI-75X15

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPR EAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFT QKSLSLSPGGGGGSGGGGSQVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS

>Sequence ID 124: Amino acid sequence of chain B of SI-75X15

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATT TACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGA AGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAG GAGACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAG AAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTG TGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAG AAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCCAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGC CTGAGCCCAGACATTGCTGACTCTGTGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTGTCTAGCTGA

>Sequence ID 125: Amino acid sequence of chain A SI-75X13

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKD YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHY TQKSLSLSPGGGGGSGGGGSEVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS

>Sequence ID 126: Nucleotide sequence of chain A SI-75X13

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGC ACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCCGCTAGCACCAAAGGCCCCTCTGTGTTCCCTCTGGCCCCCTCCTCCAAGAGCACCTCTGGAGGCACTGCTGCCCTGGGCTGCCTGGTGAAGGAC TACTTCCCAGAGCCTGTGACTGTGTCCTGGAACTCTGGAGCCCTGACCTCTGGAGTGCACACCTTCCCTGCTGTGCTGCAGAGCTCTGGCCTCTACAGCCTGTCCTCTGTGGTCACTGTGCCCTCCTCCAGCCTGGGCACCCAGACCTACATCTGCAATGTGAACCACAAGCCCTCCAACACCAAGGTGGACAAGAGAGTGGAGCCCAAGTCCTGT GACAAGACCCACACCTGCCCTCCCTGCCCAGCCCCAGAGGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGATGGAGTGGAGGTGCACAATGCCAAGACCAAGCCCAGAG AAGAGCAGTACAACTCCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCATCTCCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCC TGTCCTGTGCTGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTACAAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGGTCTCCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCACTACAC CCAGAAGAGCCTGAGCCTGAGCCCTGGAGGAGGAGGAGGCTCTGGAGGAGGAGGATCCGAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTG GAGTGGCCCCACCACCTACTATGCTGACTCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTGTCTAGCTGA

>Sequence ID 127: Amino acid sequence of chain B of SI-75X13

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIKR TVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEK TISKAKGQPREPQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPG

>Sequence ID 128: Nucleotide sequence of chain B of SI-75X13

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACCCT TGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTA CGGTGGCTGCCCCCTCTGTGTTCATCTTCCCACCCAGTGATGAGCAGCTGAAGAGTGGCACAGCCTCTGTGGTGTGCCTGCTCAACAACTTCTACCCCAGAGAAGCCAAGGTGCAGTGGAAGGTGGACAATGCCCTGCAGAGTGGCAACAGCCAGGAGAGTGTGACA GAGCAGGACAGCAAGGACAGCACCTACAGCCTGTCCTCCACCCTGACCCTGTCCAAGGCTGACTATGAGAAGCACAAGGTGTATGCCTGTGAGGTGACCCACCAGGGCCTGAGCAGCCCTGTGACCAAGAGCTTCAACCGAGGAGAGTGTGGAGGAGACAAGACCCAC ACCTGCCCTCCCTGCCCAGCCCCAGAAGCTGCTGGAGGCCCCTCTGTGTTCCTCTTCCCTCCCAAGCCCAAGGACACCCTGATGATCTCCAGGACCCCAGAAGTCACCTGTGTGGTGGTGGATGTGTCCCATGAAGACCCAGAAGTGAAGTTCAACTGGTATGTGGA TGGAGTGGAAGTGCACAATGCCAAGACCAAGCCCAGAGAAGAGCAGTACAACAGCACCTACCGAGTGGTGTCTGTGCTGACTGTGCTGCACCAGGACTGGCTGAATGGGAAGGAGTACAAGTGTGCTGTGTCCAACAAGGCCCTGCCTGCCCCCATTGAGAAGACCA TCTCCAAGGCCAAGGGCCAGCCCAGAGAGCCCCAGGTCTACACCCTGCCTCCCTCCAGAGATGAGCTGACCAAGAACCAGGTGTCCCTGTGGTGCCTGGTGAAAGGCTTCTACCCCAGTGACATTGCTGTGGAGTGGGAGAGCAATGGCCAGCCAGAGAACAACTAC AAGACCACCCCTCCTGTGCTGGACTCTGATGGCTCCTTCTTCCTGTACAGCAAGCTGACTGTGGACAAGAGCCGCTGGCAGCAGGGCAATGTGTTCTCCTGCTCTGTCATGCATGAGGCCCTGCACAACCGCTTCACCCAGAAGAGCCTGAGCCTGAGCCCTGGATGA

>Sequence ID 129: Amino acid sequence of chain A SI-38P11

QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLTVLGGGGSGGGGSGGGG SGGGGSQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAG TTVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSA ITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKG QPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQ SPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 130: Nucleotide sequence of chain A SI-38P11

CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAGCAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCAACCTGGCCAGCGGCGTGCCCGTGCGG TTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTGGAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCTGACCGTGCTGGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGT CCGGCGGTGGAGGATCACAGGTGCAGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCTACCCCGGCAA CGGCGACACCAGCTACAACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGGAGCACCTACTACGGGCGGCGACTGGTACTTCAACGTGTGGGGCGCGGCACC ACCGTGACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGG CTGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTA CTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTC CTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCT CCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCT GGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGGG GTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGT CTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 131: Amino acid sequence of chain B of SI-38P11

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTL VTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGG GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 132: Nucleotide sequence of chain B of SI-38P11

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCT TCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTC CGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGG GACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCG TCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCT CCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGG ACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGA GTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCT CAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTAC TTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTG CAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 133: Amino acid sequence of chain A of SI-76PM1

QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLTVLGGGGSGGGGSGGGG SGGGGSQVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAG TTVTVSSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKCLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSA ITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKG QPREPQVYTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSDVVMTQ SPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVLGGGGSGGGGSGGGGS GGGGSEVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 134: Nucleotide sequence of chain A of SI-76PM1

CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAGCAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCAACCTGGCCAGCGGCGTGCCCGTGCGG TTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTGGAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCTGACCGTGCTGGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGT CCGGCGGTGGAGGATCACAGGTGCAGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCTACCCCGGCAA CGGCGACACCAGCTACAACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGGAGCACCTACTACGGGCGGCGACTGGTACTTCAACGTGTGGGGCGCGGCACC ACCGTGACCGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGT CTGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTA CTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC CCCGAGAACCACAGGTGTATACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTC CTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGCGGCGGTTCAGGTGGTGGGGGATCCGACGTTGTGATGACGCAGTCT CCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTAGTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCT GGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTTGGTGGTGGTGGTTCAGGCGGGGGGTTCCGGCGGAGGCGGTTCTGGGG GTGGAGGTTCCGAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGT CTATTACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCTTGA

>Sequence ID 135: Amino acid sequence of chain B of SI-76PM1

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTL VTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGC GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 136: Nucleotide sequence of chain B of SI-76PM1

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCT TCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTC CGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGG GACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCG TCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCT CCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCTGTGGG ACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGA GTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCT CAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTAC TTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTG CAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 137: Amino acid sequence of chain A SI-68X2

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEW IGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR DGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDEL TKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 138: Nucleotide sequence of chain A SI-68X2

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAACTCCTGATCTACGATGCATCCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTC AACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAGCTGCAGG AGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGAT TGGACACATCTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCAT TTATTACTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGA GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGT CGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAG ACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCA CAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAG CAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCC ACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAAT GGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCA AGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTT CTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG

>Sequence ID 139: Amino acid sequence of chain B of SI-68X2

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKCL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 140: Nucleotide sequence of chain B of SI-68X2

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATT ACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGT GCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAG TGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGAC ACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGT CTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGC ATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATT AGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCCTTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCC ACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAAT GGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCA AGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTT CTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG

>Sequence ID 141: Amino acid sequence of chain A of SI-68E1

DIQMTQSPSSLSSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGG GSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGT MVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAI TSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKG QPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSRSLVE SGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGS GGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK

>Sequence ID 142: Nucleotide sequence of chain A of SI-68E1

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCATCCAATTTGGAAACAGGGGTCCCATCA AGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGA GGGTCCGGCGGTGGAGGATCACAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACATC TATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAA TGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGC TGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTAC TAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAG CCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGTGGAGTCTG GGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTACGCAAGCTCCGCTAGAGGCAGATTCA CCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGG CGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCAGC CAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 143: Amino acid sequence of chain B of SI-68E1

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKCL EWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYF ISRTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDEL TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 144: Nucleotide sequence of chain B of SI-68E1

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAA GCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATT ACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGT GCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAG TGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGAC ACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGT CTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGC ATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATT AGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCCTTGTTGTGTGC CTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCC TGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCC ACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAAT GGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCA AGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTT CTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG

>Sequence ID 145: Amino acid sequence of chain A of SI-68E2

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEW IGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAR DGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDEL TKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 146: Nucleotide sequence of chain A of SI-68E2

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAACTCCTGATCTACGATGCATCCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTC AACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAGCTGCAGG AGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGAT TGGACACATCTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCAT TTATTACTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGA GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGT CGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAG ACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCA CAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAG CAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCC ACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAAT GGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCA AGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTT CTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATAG

>Sequence ID 147: Amino acid sequence of chain B of SI-68E2

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGS GGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRG TLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFG GGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGG LVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGG SGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 148: Nucleotide sequence of chain B of SI-68E2

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGT CTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGCCAACA TAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGC ACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCC CTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCA GGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACA CATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAAC CACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTC TATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTT GGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACC ATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGAAG TGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGG CATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 149: Amino acid sequence of chain A of SI-68P1

DIQMTQSPSSLSSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGG GSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGT MVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAI TSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKG QPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSRSLVE SGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGGS GGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK

>Sequence ID 150: Nucleotide sequence of chain A SI-68P1

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCATCCAATTTGGAAACAGGGGTCCCATCA AGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGA GGGTCCGGCGGTGGAGGATCACAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACATC TATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAA TGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGC TGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTAC TAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGC CCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTG GAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAG CCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGC TCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTGGTGGAGTCTG GGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTACGCAAGCTCCGCTAGAGGCAGATTCA CCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGG CGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCAGC CAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 151: Amino acid sequence of chain B of SI-68P1

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVLGGGGSGGGGS GGGGSGGGGSQVQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRG TLVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFG GGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTH TCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLLESGGG LVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSGGGG SGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 152: Nucleotide sequence of chain B of SI-68P1

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGT CTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCTGTGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGCCAACA TAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGC ACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCC CTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGC GGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCA GGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACA CATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCA TAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAAC CACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTC TATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTT GGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGGCCGGTTCACC ATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGAGGTGGAAG TGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGG CATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 153: Amino acid sequence of chain A SI-49R26

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYAS SFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVD KRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALP APIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 154: Nucleotide sequence of chain A SI-49R26

TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTA AGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCA TCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGT GACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACA AGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGC CCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGA ACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 155: Amino acid sequence of chain B of SI-49R26

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASS FKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPV TKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKA LPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 156: Nucleotide sequence of chain B of SI-49R26

TTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAG TATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTT TAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCA CAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGA AGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTC CCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTTAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 157: Amino acid sequence of chain A SI-49R27

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKCLEWVGVIT GRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTI IEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSR DELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 158: Nucleotide sequence of chain A SI-49R27

GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTCAGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAAC TTCTCATCTATGAAGCATCAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCTTTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATAC TTTTATTTTATTTCCCGAACATATGTTAACTCTTTTGGGTGCGGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGAAAGGGGAAGTGCAACTGGTCGAAA GCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCTAGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGTCATAACA GGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGAACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAG ATGGCGGGAGCAGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCC TTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAA GGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCA TCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCT GGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCT TGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGA CGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGA TGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 159: Amino acid sequence of chain B of SI-49R27

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASS FKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPV TKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKA LPAPIEKTISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 160: Nucleotide sequence of chain Bs SI-49R27

TTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAG TATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTT TAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTA CAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCA CAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGA AGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTC CCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG AGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTTAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 161: Amino acid sequence of chain A SI-49R25

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKCLEWVGVIT GRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTI IEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSR DELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 162: Nucleotide sequence of chain A SI-49R25

GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTCAGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAAC TTCTCATCTATGAAGCATCAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCTTTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATAC TTTTATTTTATTTCCCGAACATATGTTAACTCTTTTGGGTGCGGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGAAAGGGGAAGTGCAACTGGTCGAAA GCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCTAGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGTCATAACA GGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGAACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAG ATGGCGGGAGCAGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCC TTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAA GGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCA TCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCT GGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCT TGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGA CGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGA TGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 163: Amino acid sequence of chain B of SI-49R25

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTKGQVTLKESGPGLVQPGQTLRLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDD KRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYC GPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKG DCALYASSFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCR DELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 164: Nucleotide sequence of chain B of SI-49R25

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCT GGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGC GTGTACCCATTCACTTTCGGGCAGGGGACAAAATTGGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTC AGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGACGACGAC AAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGT CTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGT GGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGA CCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAG ACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCA GTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGG ACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGA GGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGA CGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGA TGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 165: Amino acid sequence of chain A of SI-49P_x

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKCLEWVGVIT GRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTI IEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVV DVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSR DELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 166: Nucleotide sequence of chain A SI-49P_x

GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTCAGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAAC TTCTCATCTATGAAGCATCAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCTTTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATAC TTTTATTTTATTTCCCGAACATATGTTAACTCTTTTGGGTGCGGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCAGGCGAAGGCAGTACGAAAGGGGAAGTGCAACTGGTCGAAA GCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCTAGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGTCATAACA GGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGAACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAG ATGGCGGGAGCAGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCC TTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAA GGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCA TCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCT GGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCC TACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCT TGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGA CGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC CAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGA TGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACG GCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 167: Amino acid sequence of chain B of SI-49P_x

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTK GQVTLKESGPGLVQPGQTLRLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSTGGG GSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYAS SFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTI SKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQL LESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSG GGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 168: Nucleotide sequence of chain B of SI-49P_x

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCTTCAG TGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATTGGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGG ACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGACGACGACAAACGGTATAA TCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGG GTCCGGCGGTGGTGGATCATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCA GCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGA GCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGT GGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGAC TCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTG GAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAA GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGA GGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT AAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 169: Amino acid sequence of chain A of SI-49P8

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGS GEGSTKGEVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLV TVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQK GDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTK VDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIE KTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGS RSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGG GSGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK

>Sequence ID 170: Nucleotide sequence of chain A SI-49P8

GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTCAGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTGGGAAGGCCCCCAAACTTCTCATCTATGAAGCATCAAAGCTGGCCTCTGGGGTTCCGTCTCGCT TCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCTTTGCAACCTGACGATTTCGCAACATATTATTGCCAGGGATACTTTTATTTTTATTTCCCGAACATATGTTAACTCTTTTGGGTGCGGGACCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGGTTCA GGCGAAGGCAGTACGAAAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCTAGCGGCTTTACAATAAGTACGAACGCCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGTCATAACAGGCAGGG ACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACATCCAAGAACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGCAGTGCGATCACATCCAACAACATCTGGGGTCAGGGCACTCTTGTC ACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGG CGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCATCGAAATGCAGAAA GGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTA CTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGG TGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGA GGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGA AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCT CCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCG GTCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTACGCAAGCTCCGCT AGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGGCGGTGGCGGTAGTGGGGGAGGCGG TTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTG CAGCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 171: Amino acid sequence of chain B of SI-49P8

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTK GQVTLKESGPGLVQPGQTLRLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSTGGG GSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYAS SFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTI SKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQL LESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSG GGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 172: Nucleotide sequence of chain B of SI-49P8

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCTTCAG TGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATTGGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGG ACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGACGACGACAAACGGTATAA TCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGG GTCCGGCGGTGGTGGATCATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCA GCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGA GCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGT GGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGAC TCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTG GAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAA GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGA GGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT AAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 173: Amino acid sequence of chain A of SI-49PM1

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENC STPNTYICMQRTVGGGGSGGGGSGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDG SILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVVDGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTIS RDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLG TQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKC AVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGG GGSGGGGSRSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGG SGGGGSGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK

>Sequence ID 174: Nucleotide sequence of chain A of SI-49PM1

TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAG AAGACCAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGT ACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGGAGGCGGTGGCTCAGGCGGAGGCGGCTCAGGAGGTGGCGGTTCAGGAGGCGGCGGATCTTTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATA ACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCC ATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGGTCGACGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTG GGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGTCGTGATTCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGA GACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCT CCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACC CAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGG TCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCG GTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGA GGGTCCGGCGGTGGTGGATCCCGGTCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTAT ACTACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGT GGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCT ATGCTGCAGCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 175: Amino acid sequence of chain B of SI-49PM1

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVLGGGGSGGGGSGGGG SGGGGSQVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTL VTVSSGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGG GTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHT CPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNRFTQKSLSLSPGGGGGSGGGGSDIQMTQSPST LSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSE VQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 176: Nucleotide sequence of chain B of SI-49PM1

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCT TCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTC CGGCGGTGGAGGATCACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGG GACGACGACAAACGGTATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCG TCACGGTCTCGAGCGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCT CCTGATCTATGAAGCATCCAAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGG ACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGA GTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGC CCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATG CCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACA GGTGTACACCCTGCCCCCAAGCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTAT AGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACAGATTCACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGACATTCAGATGACACAGTCACCGTCTACGCTCT CAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCCTCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTAC TTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTGGGAGGGGGAGGAAGTGGCGGGCGGCGGAAGCGGAGGTGGTGGCTCCGGCGGGGGTGGAAGCGAAGTG CAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACGATG CAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 177: Amino acid sequence of chain A of SI-49P9

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKLTVLGSTGSGSKPGSGEGSTKGEVQLVESGGGLVQPGGSLRLSCTASGFTISTN AMSWVRQAPGKCLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSTGGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKED QDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHK PSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDELTKNQVSLSCA VKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVF FQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGSTGSGSKPGSGEGSTKGREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYS DPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGGGGSGGGGSREGPELSPDDPAGLL DLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGL

>Sequence ID 178: Nucleotide sequence of chain A SI-49P9

GAGATCGTGATGACACAATCTCCATCTACGCTCTCCGCCTCAGTGGGCGATAGAGTAATTATTACTTGTCAAGCCTCAGAGAGCATTTCATCATGGCTCGCCTGGTATCAGCAAAAGCCTG GGAAGGCCCCCAAACTTCTCATCTATGAAGCATCAAAGCTGGCCTCTGGGGTTCCGTCTCGCTTCTCCGGGTCCGGCAGTGGTGCAGAGTTTACGTTGACTATATCTTCTTTGCAACCTGAC GATTTCGCAACATATTATTGCCAGGGATACTTTTATTTATTTCCCGAACATATGTTAACTCTTTTGGGTGCGGGACCCAAACTCACTGTGCTGGGGTCTACCGGTAGTGGTTCTAAGCCTGG TTCAGGCGAAGGCAGTACGAAAGGGGAAGTGCAACTGGTCGAAAGCGGTGGAGGGCTTGTTCAACCTGGAGGAAGCCTCCGCTTGTCCTGCACGGCTAGCGGCTTTACAATAAGTACGAACG CCATGAGCTGGGTCCGGCAGGCTCCAGGTAAGTGTCTCGAATGGGTGGGGGTCATAACAGCAGGGACATTACCTACTACGCCAGTTGGGCCAAGGGTCGATTTACCATTTCTAGAGATACA TCCAAGAACACGGTGTACCTCCAGATGAATTCTCTTAGGGCGGAAGACACAGCAGTATACTACTGCGCGCGAGATGGCGGGAGCAGTGCGATCACATCCAACAACATCTGGGGTCAGGGCAC TCTTGTCACGGTGTCGACTGGCGGTGGAGGGTCCGGCGGTGGTGGATCATTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAA ACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGAC CAGGATCTGCTTAAGTTGGTAAAGAGCTACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCATCGA AATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAATACCTACATTTGTATGCAAAGAACGGTTGCTAGCACCAAGGGCCCATCGG TCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGC GGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCC CAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAAC CCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCC AAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCT CCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTCCTGCGCCG TCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCGTGAGCAAG CTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGG GTCCGGCGGTGGTGGATCCCGAGAGGGCCCCGAGCTGTCTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGTGGCTCAGAATGTTCTGCTCATTGATG GACCACTCTCTTGGTATAGTGACCCCGGTCTGGCCGGGGTGAGTCTGACCGGCGGGCTCTCTTATAAAGAGGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTTATTACGTTTTTTTT CAGCTGGAGCTCAGGCGCGTGGTGGCCGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGCTGCAGGTGCTGCCGCACTGGCTTTAACTGTTGACCTCCC TCCGGCCTCTTCTGAAGCTAGAAACAGCGCTTTCGGCTTCCAAGGGCGCCTGCTGCACCTGAGCGCAGGCCAGCGCTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACACGCTTGGC AGCTCACACAGGGTGCCACGGTTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACGA GAAGGGCCAGAGTTAAGTCCAGATGACCCTGCTGGGCTTTTGGACCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGCCCCCTGAGTTGGTACAGCGA TCCCGGGCTGGCAGGCGTGTCACTTACAGGGGGCCTCTTACAAGGAAGACACCAAGGAGTTAGTGGTCGCTAAGGCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTG TGGCAGGAGAGGGTAGCGGCAGCGTGTCTTTAGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACCGTGGATCTCCCCCCAGCCTCATCTGAAGCTAGG AACAGTGCATTTGGCTTTCAGGGACGCTTGCTGCACCTCTCCGCTGGACAGAGGCTGGGCGTGCACCTTCACACAGAGGCCCGTGCCAGGCATGCATGGCAGCTCACTCAGGGGGCAACAGT GCTGGGTCTCTTCCGCGTGACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGTGAGGGGCCAGAACTGTCCCCCGATGACCCAGCCGGACTGCTCGATC TCAGACAGGCATGTTCGCTCAGCTTGTAGCCCAAAATGTCCTCCTGATTGACGGCCCTTTGAGCTGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAGGCCTCTCCTACAAG GAAGACACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAGCTGCGGAGAGTTGTGGCCGGGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCA GCCCCTGCGCAGCGCCGCTGGAGCCGCCGCCCTTGCTCTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTCAAGGACGTCTCCTGCACTTGTCCGCAG GACAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCTTGGCAGCTTACCCAGGGAGCCACCGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTAA

>Sequence ID 179: Amino acid sequence of chain B of SI-49P9

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKLEIKGSTGSGSKPGSGEGSTK GQVTLKESGPGLVQPGQTLRLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSTGGG GSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYAS SFKGYIENCSTPNTYICMQRTVRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSF NRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTI SKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQL LESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSG GGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 180: Nucleotide sequence of chain B of SI-49P9

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTGGCTTCCGGCGTACCTAGCCGCTTCAG TGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAATTGGAGATAAAGGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGG ACAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGGCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGACGACGACAAACGGTATAA TCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTGTCGACTGGCGGTGGAGG GTCCGGCGGTGGTGGATCATTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCA GCCTTCTGAAAGTATACAGCAAAGAGGACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGA GCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTGCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGT GGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCA ACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTC AACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGAC TCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTG GAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAA GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCTGGTGGAGGCGGTTCAGGCGGA GGTGGAAGTGGTGGTGGCGGCTCTGGAGGCGGCGGATCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT AAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 181: Amino acid sequence of SI-1C3 heavy chain

QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQG TMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK THTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEK TISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 182: SI-1C3 heavy chain nucleotide sequence

CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGGGACTGGAGTGGATTGGACACATCTATTACAGT GGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGGAATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGA CAATGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGT GCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACT CACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCA TCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAA GACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAATGA

>Sequence ID 183: Amino acid sequence of SI-1C3 light chain

DIQMTQSPSSLSSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

>Sequence ID 184: SI-1C3 light chain nucleotide sequence

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCATCCAATTT GGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCCGCTCGCTTTCGGCGGAGGGACCAAGGTGGAAATTAAAC GTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAG AGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG

>Sequence ID 185: Amino acid sequence of SI-1C7

EPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSQ VQLQESGGGLVKPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGG SGGGGSGGGGSQSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL

>Sequence ID 186: Nucleotide sequence of SI-1C7

GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAACTCCTGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAA CTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCT CCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTG CTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCAGGTG CAGCTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTC TGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGTTCAG GCGGAGGTGGTTCCGGCGGTGGCGGCTCCCAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTAT GATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTATAA

>Sequence ID 187: Amino acid sequence of the heavy chain of SI-9C21

EVQLVESGGGLVQPGGSLRLSCTASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQ GTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCD KTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFLLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 188: SI-9C21 heavy chain nucleotide sequence

GAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGCACGGCTAGTGGCTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGTCGGCGTCATCACCGGCAGGGACATT ACATACTATGCGAGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTTCAAAGAATACCGTTTACCTTCAAATGAATAGCTTGCGCGCGGAAGACACAGCTGTGTATTACTGCGCGCGGGATGGAGGTAGTTCCGCCATAACTTCCAACAACATATGGGGACAAG GCACGCTGGTTACTGTGTCGTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGG CGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAA ACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTTCTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTAC GTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAA CCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTA CAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCCTGCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTGA

>Sequence ID 189: Amino acid sequence of SI-9C21 light chain

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGQGTKL TVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

>Sequence ID 190: SI-9C21 light chain nucleotide sequence

GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTCCGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGTCAAAATTGGCG TCTGGTGTCCCATCTAGGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGTCTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTTCGGCCAAGGAACAAAGTTGACT GTTCTTCGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG

>Sequence ID 191: Amino acid sequence of SI-35FS11

EPKSSDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTI SKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSRS LVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSSGGGGSGGGG SGGGGSGGGGSDVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKVEIK

>Sequence ID 192: Nucleotide sequence SI-35FS11

GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAAC TGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCC AAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTG GACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCCGGTCGCTG GTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGCCAGGCTCCAGGAAGGGGCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACTACGCGAGCTCCGCGAGAGGC AGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCT GGCGGCGGAGGGTCCGGCGGTGGAGGATCAGACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCA GCCAATCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACCTGGAGCCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 193: Amino acid sequence of SI-3FS11

EPKSSDKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISK AKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGGGGGSGGGGSEVQLL ESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSSGGGGSG GGGSGGGGSGGGGSDIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVEIK

>Sequence ID 194: Nucleotide sequence SI-3FS11

GAGCCCAAATCTTCCGACAAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTG GTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAG CCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCC GACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCCGAGGTGCAGCTGTTGGAG TCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTACGACGCGAACTGGGCGAAAGG CCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGCGGTGGAGGCGGATCTGGCGGAG GTGGTTCCGGCGGTGGCGGCTCCGGTGGAGGGCGGCTCTGACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTAT AAGGCATCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTCGGCGGAGGGACCAAGGTGGAGATCAAATAA

>Sequence ID 195: Amino acid sequence of chain A SI-68X1

DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQSTYYNNIIYGAAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFSFSGTQYVCWVRQAPGKCLE WIGCIYVDVANTYYATSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASHDTVCAGCGLDLWGQGTLVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVY YCARDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSH EDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDE LTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 196: Nucleotide sequence of chain A SI-68X1

GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTA AGCTCCTGATCTATGATGCTTCCACTCTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAA TCTACTTATTATAATAATTCATTTATGGGGCTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCAGAGGTGC AGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAG TGGATCGGATGCATTTATGTGGATGTGGCTAACACTTACTACGCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACA CGGCTGTGTATTACTGTGCGAGTCATGATACTGTTTGTGCTGGTTGTGGTTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTG GTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGG AGTCATTACTGGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATT ACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCAC CTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCT ACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCAC ACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGA AGACCCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGG CTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCT GACCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCT CCTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

>Sequence ID 197: Amino acid sequence of chain B of SI-68X1

DIQMTQSPSSLSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIKGGGGSGGGGSGGGGSGGGGSQVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEW IGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSTGGGGSGGGGSDVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFIS RTYVNSFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDP EVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVYTLPPCRDELT KNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 198: Nucleotide sequence of chain B of SI-68X1

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCT AAACTCCTGATCTACGATGCATCCAATTTGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGT CAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACAGGTGCAGCTGCAG GAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGG ATTGGACACATCTATTACAGTGGGAACACCAATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCC ATTTATTACTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGACGTCGTGATGACCCAGTCTCCT TCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCC AAACTGGCATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGT CGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG CTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTG ACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACTCACACATGCCCA CCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCT GAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAAT GGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACC AAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCC TTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

>Sequence ID 199: Amino acid sequence of chain A SI-68X3

DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIKGGGGSGGGGSGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVA RIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSTGGGGSGGGGSEVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCA RDGGSSAITSNNIWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHED PEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKTISKAKGQPREPQVCTLPPSRDEL TKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 200: Nucleotide sequence of chain A SI-68X3

GACATCCAAATGACGCAGTCTCCCTCCAGTTTGAGTGCAAGTGTGGGAGACAGAGTTACGATCACATGTAGGGCAAGTCAGGACGTCAATACAGCCGTCGCATGGTACCAGCAGAAGCCTGGAAAGGCCCCG AAACTTCTGATTTACTCTGCAAGTTTCCTCTACAGTGGTGTTCCTAGTCGCTTCAGTGGGTCTCGGTCAGGCACCGATTTTACCCTGACAATTAGCAGCTTGCAACCGGAAGATTTTTGCGACCTATTATTGCC AGCAACATTATACCACCCCTCCCACATTTGGACAAGGCACGAAGGTAGAGATTAAAGGCGGTGGAGGGAGCGGTGGAGGCGGTTCCGGTGGAGGTGGTTCTGGTGGAGGTGGCAGTGAAGTACAGCTTGTTG AGAGTGGTGGTGGACTTGTCCAACCAGGGGGAAGTCTGCGGCTGTCATGCGCAGCCTCTGGCTTCAACATTAAGGACACCTACATTCACTGGGTTCGGCAAGCGCCGGGGAAGGGGCTGGAATGGGTCGCCAG GATATACCCTACCAACGGGTACACCAGGTATGCAGATAGCGTTAAGGGTAGATTCACTATTTCAGCTGACACTAGCAAGAACACCGCGTATCTCCAGATGAACTCCCTTCGCGCCGAGGATACGGCTGTGTA CTACTGCTCTAGGTGGGGAGGAGATGGGTTTTACGCAATGGATTACTGGGGACAGGGAACACTCGTTACGGTGTCGACAGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGAGGTGCAGCTGGTGGAGTCTGGG GGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACT GGTCGTGATATCACATACTACGCGAGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGA GAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCAGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGG GCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCT CAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGACAAAACTCACACATG CCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGAC CCTGAGGTCAAGTTCAACTGGTACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTG AATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTGTACCCTGCCCCCATCCCGGGATGAGCTGA CCAAGAACCAGGTCAGCCTGTCCTGCGCCGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTC CTTCTTCCTCGTGAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

>Sequence ID 201: Amino acid sequence of chain B of SI-68X3

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIK RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGDKT HTCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYASTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIEKT ISKAKGQPREPQVYTLPPCRDELTKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

>Sequence ID 202: Nucleotide sequence of chain B SI-68X3

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCT GGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA CGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTC ACAGAGCAGGACGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGAGGCGACAAAACT CACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGGACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGTACGTG GACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACGCCAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAAACC ATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATGTCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGTGGTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTAC AAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTAAA

>Sequence ID 203: Amino acid sequence of αEGFR VH

QVQLQQSGPGLVKPSETLSITCTVSGFSLTNYGVHWIRQAPGKGLEWLGVIWSGGNTDYNTPFTSRFTITKDNSKNQVYFKLRSVRADDTAIYYCARALTYYDYEFAYWGQGTLVTVSS

>Sequence ID 204: Nucleotide sequence of αEGFR VH

CAAGTACAGTTGCAGCAATCCGGTCCCGGTCTCGTCAAACCGAGTGAGACGCTTAGTATAACGTGTACTGTTTCAGGCTTTAGCCTTACGAACTATGGAGTTCACTGGATTCGGCAGGCACCCGGCAAAGGTTTGGAATGGCTGGGTGTTATTTGGTCAGGTGGAAATACAGACTATA ACACCCCCTTTACAAGTCGGTTCACAATTACGAAAGATAATTCCAAAAATCAAGTTTATTTCAAGTTGAGATCCGTCCGCGCGGACGACACTGCGATCTACTATTGTGCGAGGGCACTGACCTACTACGATTACGAATTTGCGTATTGGGGGCAAGGGACTCTTGTAACAGTCTCGAGC

>Sequence ID 205: Amino acid sequence of αEGFR VL

EIVLTQSPSTLSVSPGERATFSCRASQSIGTNIHWYQQKPGKPPRLLIKYASESISGIPDRFSGSGSGTEFTLTISSVQSEDFAVYYCQQNNNWPTTFGPGTKLTVL

>Sequence ID 206: Nucleotide sequence of αEGFR VL

GAAATCGTCCTTACACAATCTCCTAGCACACTGAGTGTGAGCCCCGGCGAACGCGCGACTTTCTCTTGCAGGGCAAGTCAATCCATAGGGACTAATATACATTGGTATCAACAAAAGCCAGGTAAACCACCCAGGCTTTTGATTAAGTATGCAAGTGAGT CTATTTCCGGTATCCCTGACCGCTTCTCTGGATCAGGCAGTGGCACAGAGTTCACACTCACCATATCTAGTGTGCAATCAGAGGACTTCGCCGTGTATTACTGCCAACAGAATAATAACTGGCCGACTACCTTCGGACCCGGTACAAAGCTGACCGTTTTA

>Sequence ID 207: Amino acid sequence of αEGFR* VH

QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKGLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVSS

>Sequence ID 208: Nucleotide sequence of αEGFR* VH

CAAGTGCAACTCCAGGAGAGTGGGCCGGGATTGGTTAAACCGAGCGAGACCCTGAGTCTCACGTGTACAGTTTCAGGCGGGAGCGTGAGCTCAGGCGACTATTACTGGACATGGATAAGACAGAGTCCTGGAAAGGGCCTGGAGTGGATCGGTCATATTTATTATTCAGGGAACACTA ACTATAATCCATCTTTGAAATCCCGATTGACAATCTCTATCGATACCAGTAAAACCCAGTTTAGCCTCAAGCTGTCCAGCGTTACTGCTGCAGACACAGCCATATACTATTGCGTACGCGATCGCGTGACTGGAGCCTTCGACATATGGGGGCAGGGAACGATGGTAACAGTCTCGAGC

>Sequence ID 209: Amino acid sequence of αEGFR* VL

DIQMTQSPSSLSSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGGGTKVEIK

>Sequence ID 210: Nucleotide sequence of αEGFR* VL

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCATCCAATT TGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCCGCTCGCTTTCGGCGGAGGGACCAAGGTGGAAATTAAA

>Sequence ID 211: Amino acid sequence of cross-linked αEGFR* VH

QVQLQESGPGLVKPSETLSLTCTVSGGSVSSGDYYWTWIRQSPGKCLEWIGHIYYSGNTNYNPSLKSRLTISIDTSKTQFSLKLSSVTAADTAIYYCVRDRVTGAFDIWGQGTMVTVST

>Sequence ID 212: Nucleotide sequence of cross-linked αEGFR* VH

CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTGATTACTACTGGACCTGGATCCGGCAGTCCCCAGGGAAGTGCCTGGAGTGGATTGGACACATCTATTACAGTGGGAACACCA ATTATAACCCCTCCCTCAAGAGCCGACTCACCATATCAATTGACACGTCCAAGACTCAGTTCTCCCTGAAGCTGAGTTCTGTGACCGCTGCGGACACGGCCATTTATTACTGTGTGCGAGATCGAGTGACTGGTGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTGTCGACA

>Sequence ID 213: Amino acid sequence of cross-linked αEGFR* VL

DIQMTQSPSSLSSASVGDRVTITCQASQDISNYLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYFCQHFDHLPLAFGCGTKVEIK

>Sequence ID 214: Nucleotide sequence of cross-linked αEGFR* VL

GACATCCAGATGACCCAGTCTCCATCCTCCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCGAGTCAGGACATCAGCAACTATTTAAATTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAACTCCTGATCTACGATGCATCCAATT TGGAAACAGGGGTCCCATCAAGGTTCAGTGGAAGTGGATCTGGGACAGATTTTACTTTCACCATCAGCAGCCTGCAGCCTGAAGATATTGCAACATATTTCTGTCAACACTTTGATCATCTCCCGCTCGCTTTCGGCTGTGGGACCAAGGTGGAAATTAAA

>Sequence ID 215: Amino acid sequence of αCD19 VH

QVTLKESGPGLVQPGQTLSLTCAFSGFSLSTSGMGVGWIRQPPGKGLEWLAHIWWDDDKRYNPALKSRLTISKDTSKNQVYLQMNSLDAEDTAVYYCARMELWSYYFDYWGQGTLVTVSS

>Sequence ID 216: Nucleotide sequence of αCD19 VH

CAGGTCACATTGAAGGAATCTGGCCCCGGCCTTGTTCAGCCAGGACAGACCCTTAGCCTCACCTGTGCCTTCAGTGGTTTTTCTCTTAGCACTAGCGGTATGGGGGTCGGCTGGATTCGGCAGCCTCCCGGCAAAGGTCTTGAGTGGTTGGCTCACATTTGGTGGGACGACGACAAACGG TATAATCCTGCCTTGAAAAGTCGGCTGACCATTAGTAAGGATACCTCAAAAAATCAAGTGTACTTGCAAATGAATAGCCTTGACGCCGAGGATACGGCTGTATATTATTGCGCGCGGATGGAACTCTGGTCTTACTACTTTGATTATTGGGGGCAGGGGACTCTCGTCACGGTCTCGAGC

>Sequence ID 217: Amino acid sequence of αCD19 VL

ENVLTQSPASLSASPGERVTITCSASSSVSYMHWYQQKPGQAPKLWIYDTSKLASGVPSRFSGSGSGNDHTLTISSMEPEDFATYYCFQGSVYPFTFGQGTKVTVL

>Sequence ID 218: Nucleotide sequence of αCD19 VL

GAAAATGTATTGACACAGAGCCCCGCCTCCCTCAGTGCCTCACCTGGGGAAAGGGTAACTATCACTTGCTCTGCATCAAGCAGCGTCTCATACATGCATTGGTATCAACAAAAGCCTGGACAGGCCCCCAAGCTCTGGATATACGATACGAGCAAGCTG GCTTCCGGCGTACCTAGCCGCTTCAGTGGTTCCGGCTCAGGCAACGATCACACCCTTACGATTTCCAGTATGGAACCCGAAGATTTTGCAACTTATTATTGTTTCCAGGGGAGCGTGTACCCATTCACTTTCGGGCAGGGGACAAAAGTGACCGTCCTA

>Sequence ID 219: Amino acid sequence of αCD3 VH

EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS

>Sequence ID 220: Nucleotide sequence of αCD3 VH

GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCG AGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCA

>Sequence ID 221: Amino acid sequence of αCD3 VL

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGGGTKVEIK

>Sequence ID 222: Nucleotide sequence of αCD3 VL

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCT GGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA

>Sequence ID 223: Amino acid sequence of cross-linked αCD3 VH

EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKCLEWIGVITGRDITYYASWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS

>Sequence ID 224: Nucleotide sequence of cross-linked αCD3 VH

GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCATCAGTACCAATGCAATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGTCTGGAGTGGATCGGAGTCATTACTGGTCGTGATATCACATACTACGCG AGCTGGGCGAAAGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACGGTGGTTCTTCTGCTATTACTAGTAACAACATTTGGGGCCAGGGAACCCTGGTCACCGTGTCCTCA

>Sequence ID 225: Amino acid sequence of cross-linked αCD3 VL

DVVMTQSPSTLSASVGDRVTINCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGCGTKVEIK

>Sequence ID 226: Nucleotide sequence of cross-linked αCD3 VL

GACGTCGTGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCAATTGCCAAGCCAGTGAGAGCATTAGCAGTTGGTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGAAGCATCCAAACTGGCATCT GGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAAGGCTATTTTTATTTTATTAGTCGTACTTATGTAAATTCTTTCGGCTGTGGGACCAAGGTGGAGATCAAA

>Sequence ID 227: Amino acid sequence of αCD3* VH

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLVTVSS

>Sequence ID 228: Nucleotide sequence of αCD3* VH

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGCAATA CATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACAGTTTCATCC

>Sequence ID 229: Amino acid sequence of αCD3* VL

DPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSARDSGNIQSFGGGTRVEIK

>Sequence ID 230: Nucleotide sequence of αCD3* VL

GATCCTCAATTGACCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCCTTATCTACTCAGCTTCAACC CTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCACGGGATTCCGGGAACATACAGTCCTTTGGGGTGGAACTCGGGTGGAGATAAAA

>Sequence ID 231: Amino acid sequence of αCD3** VH

EVQLVESGGGLVQPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISRDTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS

>Sequence ID 232: Nucleotide sequence of αCD3** VH

GAAGTCCAATTGGTAGAAAGTGGCGGTGGTCTGGTGCAACCTGGTGGATCTCTTCGCCTCTCATGCGCCGCTAGTGGCTTTACTATTTCAACTAATGCGATGAGCTGGGTTCGCCAGGCCCCCGGCAAAGGACTTGAGTGGGTCGGCGTCATCACCGGCAGGGACATTACATACTATGCG AGTTGGGCAAAGGGCAGGTTCACGATTAGCCGCGATACTTCAAAGAATACCGTTTACCTTCAAATGAATAGCTTGAGGGCGGAAGACACAGCTGTGTATTACTGCGCGAGGGATGGAGGTAGTTCCGCCATAACTTCCAACAACATATGGGGACAAGGCACGCTGGTTACTGTCTCGAGT

>Sequence ID 233: Amino acid sequence of αCD3** VL

EIVMTQSPSTLSASVGDRVIITCQASESISSWLAWYQQKPGKAPKLLIYEASKLASGVPSRFSGSGSGAEFTLTISSLQPDDFATYYCQGYFYFISRTYVNSFGQGTKLTVL

>Sequence ID 234: Nucleotide sequence of αCD3** VL

GAAATCGTTATGACGCAGAGTCCCTCCACGCTCTCCGCTAGTGTCGGGGATCGCGTCATTATCACATGCCAGGCCTCCGAGTCAATCAGCAGCTGGCTTGCATGGTATCAACAGAAGCCGGGAAAAGCTCCTAAATTGCTGATCTATGAAGCGTCAAAATTGGCGTCT GGTGTCCCATCTAGGTTCTCCGGCTCTGGGTCTGGTGCGGAATTTACTTTGACAATCTCCAGTCTTCAACCAGACGATTTCGCTACCTACTACTGCCAAGGGTATTTCTATTTTATAAGCCGGACATATGTAAACTCCTTCGGCCAAGGAACAAAGTTGACTGTTCTT

>Sequence ID 235: Amino acid sequence of αCD3*** VH

QQLLESGGRLIKPGATLRLTCKTSGFTISTNAMSWVRQPPGKGLEWIGVITGRDITYYASWAKGRFTISKTSINTVFLQMRSLRAEDTAVYYCARDGGSSAITSNNIWGRGTLVTVSS

>Sequence ID 236: Nucleotide sequence αCD3*** VH

CAGCAGCTGCTGGAAAGCGGCGGCCGCCTGATTAAACCGGGCGCGACCCTGCGCCTGACCTGCAAAACCAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGCCGCCGGGCAAAGGCCTGGAATGGATTGGCGTGATTACCGGCCGCGATATTACCTATTATGCG AGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCATTAACACCGTGTTTCTGCAGATGCGCAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTACCAGCAACAACATTTGGGGCCGCGGCACCCTGGTGACCGTGAGCAGC

>Sequence ID 237: Amino acid sequence of αCD3*** VL

DVQMTQSPSTLSATVGQRVTINCQASESISSWLAWYQQKPGQPPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLQSDDFATYYCQGYFYFISRTYVNSFGGGTRVEIK

>Sequence ID 238: Nucleotide sequence αCD3*** VL

GATGTGCAGATGACCCAGAGCCCGAGCACCCTGAGCGCGACCGTGGGCCAGCGCGTGACCATTAACTGCCAGGCGAGCGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGCCGCCGAAACTGCTGATTTATGAAGCGAGCAAACTGGCGAGC GGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGCCTGCAGAGCGATGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTTTGGCGGCGGCACCCGCGTGGAAATTAAA

>Sequence ID 239: Amino acid sequence of αCD3**** VH

QQLVESGGGLVKPGGSLRLSCAASGFTISTNAMSWVRQAPGKGLEWVGVITGRDITYYASWAKGRFTISKTSKNTVYLQMNSLRAEDTAVYYCARDGGSSAITSNNIWGQGTLVTVSS

>Sequence ID 240: Nucleotide sequence αCD3**** VH

CAGCAGCTGGTGGAAAGCGGCGGCGGCCTGGTGAAACCGGGCGGCAGCCTGCGCCTGAGCTGCGCGGCGAGCGGCTTTACCATTAGCACCAACGCGATGAGCTGGGTGCGCCAGGCGCCGGGCAAAGGCCTGGAATGGGTGGGCGTGATTACCGGCCGCGATATTACCTATTATGCG AGCTGGGCGAAAGGCCGCTTTACCATTAGCAAAACCAGCAAAAACACCGTGTATCTGCAGATGAACAGCCTGCGCGCGGAAGATACCGCGGTGTATTATTGCGCGCGCGATGGCGGCAGCAGCGCGATTACCAGCAACAACATTTGGGGCCAGGGCACCCTGGTGACCGTGAGCAGC

>Sequence ID 241: Amino acid sequence of αCD3**** VL

DVVMTQSPSSLSASVGDRVTISCQASESISSWLAWYQQKPGQAPKLLIYEASKLASGVPSRFSGSGSGTEFTLTISSLEPEDFATYYCQGYFYFISRTYVNSFGGGTKVEIK

>Sequence ID 242: Nucleotide sequence αCD3**** VL

GATGTGGTGATGACCCAGAGCCCGAGCAGCCTGAGCGCGAGCGTGGGCGATCGCGTGACCATTAGCTGCCAGGCGAGCGAAAGCATTAGCAGCTGGCTGGCGTGGTATCAGCAGAAACCGGGCCAGGCGCCGAAACTGCTGATTTATGAAGCGAGCAAACTGGCGAGC GGCGTGCCGAGCCGCTTTAGCGGCAGCGGCAGCGGCACCGAATTTACCCTGACCATTAGCAGCCTGGAACCGGAAGATTTTGCGACCTATTATTGCCAGGGCTATTTTTATTTTATTAGCCGCACCTATGTGAACAGCTTTGGCGGCGGCACCAAAGTGGAAATTAAA

>Sequence ID 243: Amino acid sequence of αPD-L1 VH

EVQLLESGGGLVQPGGSLSLSCAASGFSFSSGYDMCWVRQAPGKGLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 244: Nucleotide sequence of αPD-L1 VH

GAAGTGCAATTGCTCGAAAGTGGTGGCGGACTTGTGCAACCTGGTGGAAGCCTCTCACTCTCTTGCGCGGCGAGTGGTTTTAGCTTCAGTAGCGGCTACGATATGTGCTGGGTAAGACAGGCTCCTGGTAAAGGCCTTGAGTGGATTGCGTGTATCGCCGCCGGGTCTGCTGGTATAACATACG ATGCAAACTGGGCGAAAGGGCGCTTCACAATCTCCAGGGACAACTCAAAAAATACATTGTACCTCCAGATGAATAGCCTGAGAGCCGAAGACACCGCAGTCTACTATTGCGCAAGGTCAGCATTTAGCTTCGATTATGCAATGGATCTTTGGGGCCAGGGGACGCTCGTCACCGTCTCATCTTGA

>Sequence ID 245: Amino acid sequence of αPD-L1 VL

DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGGGTKVTVL

>Sequence ID 246: Nucleotide sequence of αPD-L1 VL

GACATTCAGATGACACAGTCACCGTCTACGCTCTCAGCCTCAGTAGGCGATAGGGTGACTATCACCTGCCAAGCCTCCCAATCTATAAGTTCACACCTCAACTGGTATCAACAGAAACCCGGTAAAGCACCGAAGCTGCTCATCTACAAGGCATCAACTCTTGCC TCAGGTGTGCCTAGTCGCTTCTCCGGGAGCGGCTCCGGTACTGAGTTTACTTTGACGATATCTTCCCTCCAACCCGACGACTTCGCCACATACTATTGTCAGCAGGGTTATAGTTGGGGAAATGTTGACAATGTGTTTGGAGGGGGAACGAAAGTGACTGTGTTG

>Sequence ID 247: Amino acid sequence α4-1BB VH

EVQLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKGLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 248: Nucleotide sequence α4-1BB VH

GAGGTTCAGTTGGTTGAAAGTGGGGGGGGACTCGTTCAGCCTGGAGGCTCTTTGCGACTTTCTTGTACCGCTTCTGGGTTCACTATAAGTTCATATCATATGCAATGGGTAAGACAGGCGCCTGGTAAGGGACTTGAATACATAGGAACAATAAGCTCTGGTGGTAACGTCTAT TACGCCTCATCCGCGCGGGGGAGGTTTACAATTTCCAGGCCTTCTAGCAAAAACACGGTAGATCTGCAAATGAACTCTCTTCGCGCTGAAGATACAGCAGTCTACTACTGCGCCAGGGATTCAGGGTATTCTGACCCCATGTGGGGGCAGGGCACATTGGTTACCGTGTCCTCT

>Sequence ID 249: Amino acid sequence α4-1BB VL

DVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGGGTKLTVL

>Sequence ID 250: Nucleotide sequence α4-1BB VL

GACGTTGTGATGACGCAGTCTCCTAGTTCAGTATCAGCGTCTGTTGGGGATCGAGTCACGATTACATGCCAGGCGAGCCAAAATATTAGGACGTATCTGTCTTGGTATCAACAAAAGCCTGGTAAGGCTCCAAAACTCCTCATTTACGCCGCTGCCAACTTGGCTA GTGGAGTACCTTCACGCTTTAGTGGGTCAGGTTCTGGAACAGATTTTACGTTGACGATCTCCGATTTGGAACCAGGGGACGCTGCCACGTATTATTGCCAGTCCACCTACCTCGGGACTGACTACGTTGGTGGGGCGTTTGGCGGAGGAACAAAACTCACTGTACTT

>Sequence ID 251: Amino acid sequence 41BBL

REGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQ RLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGSTGSGSKPGSGEGSTKGREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPLSWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAG EGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGLGGGGSGGGGSREGPELSPDDPAGLLDLRQGMFAQLVAQNVLLIDGPL SWYSDPGLAGVSLTGGLSYKEDTKELVVAKAGVYYVFFQLELRRVVAGEGSGSVSLALHLQPLRSAAGAAALALTVDLPPASSEARNSAFGFQGRLLHLSAGQRLGVHLHTEARARHAWQLTQGATVLGLFRVTPEIPAGL

>Sequence ID 252: Nucleotide sequence 41BBL

CGAGAGGGCCCCGAGCTGTCTCCTGATGACCCAGCAGGCCTCTTGGACTTGCGGCAGGGTATGTTCGCTCAACTTGTGGCTCAGAATGTTCTGCTCATTGATGGACCACTCTCTTGGTATAGTGACCCCGGTCTGGCCGGGGTGAGTCTGACCGGCGGGCTCTCTTATAAAGAGGATACTAAGGAACTGGTCGTAGCAAAAGCGGGCGTTT ATTACGTTTTTTTTCAGCTGGAGCTCAGGCGCGTGGTGGCCGGCGAGGGCAGTGGCTCTGTGTCCCTGGCCCTGCACTTACAGCCCTTGAGAAGCGCTGCAGGTGCTGCCGCACTGGCTTTAACTGTTGACCTCCCTCCGCCTCTTCTGAAGCTAGAAACAGCGCTTTCGGCTTCCAAGGGCGCCTGCTGCACCTGAGCGCAGGCCAGCG CTTAGGTGTGCACCTTCATACAGAGGCCAGGGCCCGACACGCTTGGCAGCTCACACAGGGTGCCACGGTTCTCGGACTTTTCCGCGTTACTCCCGAGATCCCCGCTGGCCTCGGAAGTACTGGTTCTGGGTCTAAACCCGGTTCCGGCGAAGGTAGTACTAAAGGACGAGAAGGGCCAGAGTTAAGTCCAGATGACCCTGCTGGGCTTTTG GACCTGCGGCAGGGCATGTTCGCTCAACTGGTGGCTCAGAACGTGCTGCTGATCGATGGCCCCCTGAGTTGGTACAGCGATCCCGGGCTGGCAGGCGTGTCACTTACAGGGGGCCTCTCTTACAAGGAAGACACCAAGGAGTTAGTGGTCGCTAAGGCTGGCGTGTATTACGTGTTCTTCCAACTGGAGCTGAGAAGGGTTGTGGCAGGAG AGGGTAGCGGCAGCGTGTCTTTAGCCCTTCACTTGCAGCCCCTGAGGTCTGCTGCAGGTGCAGCCGCTCTCGCGCTCACCGTGGATCTCCCCCCAGCCTCATCTGAAGCTAGGAACAGTGCATTTGGCTTTCAGGGACGCTTGCTGCACCTCTCCGCTGGACAGAGGCTGGGCGTGCACCTTCACACAGAGGCCCGTGCCAGGCATGCATG GCAGCTCACTCAGGGGGCAACAGTGCTGGGTCTCTTCCGCGTGACTCCTGAAATACCAGCTGGACTTGGCGGTGGAGGCAGCGGCGGAGGAGGATCTCGTGAGGGGCCAGAACTGTCCCCCGATGACCCAGCCGGACTGCTCGATCTCAGACAGGGCATGTTCGCTCAGCTTGTAGCCCAAAATGTCCTCCTGATTGACGGCCCTTTGAGC TGGTATAGTGATCCCGGCTTGGCCGGGGTATCTCTGACCGGAGGCCTCTCCTACAAGGAAGACACCAAAGAGCTGGTGGTGGCAAAAGCGGGGGTGTATTATGTGTTCTTTCAGCTCGAGCTGCGGAGAGTTGTGGCCGGGGAAGGGTCTGGGAGCGTATCTCTTGCACTTCACCTGCAGCCCCTGCGCAGCGCCGCTGGAGCCGCCGCCC TTGCTCTTACTGTGGATCTGCCTCCTGCTTCCTCAGAAGCACGCAACAGCGCCTTCGGCTTTCAAGGACGTCTCCTGCACTTGTCCGCAGGACAGAGGTTGGGCGTCCATTTACACACTGAGGCACGGGCACGGCACGCTTGGCAGCTTACCCAGGGAGCCACCGTGCTGGGACTCTTTAGAGTGACACCCGAGATCCCCGCTGGCTTGTGA

>Sequence ID 253: Amino acid sequence of NKG2D dimer

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTVGGGGSGGGGS GGGGSGGGGSFLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

>Sequence ID 254: Nucleotide sequence of NKG2D dimer

TTTCTTAATTCCCTTTTCAACCAAGAGGTTCAGATCCCCTTGACTGAAAGCTATTGCGGCCCTTGTCCGAAAAACTGGATATGTTACAAGAATAATTGTTACCAATTCTTCGACGAAAGCAAGAACTGGTATGAGAGTCAGGCGTCTTGTATGAGTCAGAATGCCAGCCTGCTTAAGGTTTATTCAAAAGAAGACCAGGATCTGCTTAAGTTGGTAAAGAGCT ACCACTGGATGGGGCTGGTACATATCCCAACGAATGGGTCATGGCAGTGGGAGGACGGTTCTATTCTGAGTCCAAATCTCCTGACGATCATCGAAATGCAGAAAGGGGACTGTGCCCTGTATGCATCATCCTTCAAGGGGTACATCGAGAACTGCAGTACCCCAAATACCTACATTTGTATGCAAAGAACGGTTGGAGGCGGTGGCTCAGGCGGAGGCGGCTCA GGAGGTGGCGGTTCAGGAGGCGGCGGATCTTTCCTAAACTCATTATTCAACCAAGAAGTTCAAATTCCCTTGACCGAAAGTTACTGTGGCCCATGTCCTAAAAACTGGATATGTTACAAAAATAACTGCTACCAATTTTTTGATGAGAGTAAAAACTGGTATGAGAGCCAGGCTTCTTGTATGTCTCAAAATGCCAGCCTTCTGAAAGTATACAGCAAAGAGG ACCAGGATTTACTTAAACTGGTGAAGTCATATCATTGGATGGGACTAGTACACATTCCAACAAATGGATCTTGGCAGTGGGAAGATGGCTCCATTCTCTCACCCAACCTACTAACAATAATTGAAATGCAGAAGGGAGACTGTGCACTCTATGCCTCGAGCTTTAAAGGCTATATAGAAAACTGTTCAACTCCAAATACGTACATCTGCATGCAAAGGACTGTG

>Sequence ID 255: Amino acid sequence of αHER3 VH

QVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKGLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSS

>Sequence ID 256: Nucleotide sequence of αHER3 VH

CAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTAC TATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGT

>Sequence ID 257: Amino acid sequence of αHER3 VL

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVL

>Sequence ID 258: Nucleotide sequence of αHER3 VL

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATC GGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTA

>Sequence ID 259: Amino acid sequence of αCD20 VH

QVQLQQPGAELVKPGASVKMSCKASGYTFTSYNMHWVKQTPGRGLEWIGAIYPGNGDTSYNQKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYYCARSTYYGGDWYFNVWGAGTTVTVSS

>Sequence ID 260: Nucleotide sequence of αCD20 VH

CAGGTGCAGCTGCAGCAGCCCGGCGCCGAGCTGGTGAAGCCCGGCGCCAGCGTGAAGATGAGCTGCAAGGCCAGCGGCTACACCTTCACCAGCTACAACATGCACTGGGTGAAGCAGACCCCCGGCCGGGGCCTGGAGTGGATCGGCGCCATCTACCCCGGCAACGGCGACACCAGCTACA ACCAGAAGTTCAAGGGCAAGGCCACCCTGACCGCCGACAAGAGCAGCAGCACCGCCTACATGCAGCTGAGCAGCCTGACCAGCGAGGACAGCGCCGTGTACTACTGCGCCCGGGAGCACCTACTACGGGCGGCGACTGGTACTTCAACGTGTGGGGCGCGGCACCACCGTGACCGTCTCGAGC

>Sequence ID 261: Amino acid sequence of αCD20 VL

QIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWFQQKPGSSPKPWIYATSNLASGVPVRFSGSGSGTSYSLTISRVEAEDAATYYCQQWTSNPPTFGGGTKLTVL

>Sequence ID 262: Nucleotide sequence of αCD20 VL

CAGATCGTGCTGAGCCAGAGCCCCGCCATCCTGAGCGCCAGCCCCGGCGAGAAGGTGACCATGACCTGCCGGGCCAGCAGCAGCGTGAGCTACATCCACTGGTTCCAGCAGAAGCCCGGCAGCAGCCCCAAGCCCTGGATCTACGCCACCAGCAACCTG GCCAGCGGCGTGCCCGTGCGGTTCAGCGGCAGCGGCAGCGGCACCAGCTACAGCCTGACCATCAGCCGGGTGGAGGCCGAGGACGCCGCCACCTACTACTGCCAGCAGTGGACCAGCAACCCCCCCACCTTCGGCGGCGGCACCAAGCTGACCGTGCTG

>Sequence ID 263: Amino acid sequence of EGFR VHH

EVQLQESGGGLVQAGDSLSLSCLVSGRSFNSYTMGWFRQAPGKEREFVAAILWSGPTTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAALGVLVLAPGNVYSYWGQGTQVTVSS

>Sequence ID 264: Nucleotide sequence of EGFR VHH

GAGGTGCAGCTGCAGGAGTCTGGCGGCGGCCTGGTGCAGGCTGGGGACAGCCTGAGCCTGTCCTGCCTGGTGTCTGGCCGCTCCTTCAACTCCTACACCATGGGCTGGTTCCGCCAGGCCCCTGGGAAGGAGCGGGAGTTTGTGGCTGCCATCCTGTGGAGTGGCCCCACCACCTACTATGCTGAC TCTGTGAAGGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACTGTGTACCTGCAGATGAACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGCCCTGGGAGTGCTGGTGCTGGCCCCTGGCAATGTGTACAGCTACTGGGGCCAGGGCACCCAGGTGACTGTCTCGAGC

>Sequence ID 265: Amino acid sequence of HER3 VHH

QVQLVQSGGGLVQAGGSLSLSSCAFSGRTFSMYTMGWFRQAPGKEREFVAANRGRGLSPDIADSVNGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAADLQYGSSWPQRSSAEYDYWGQGTTVTVSS

>Sequence ID 266: HER3 VHH Nucleotide Sequence

CAGGTGCAGCTGGTGCAGTCTGGCGGAGGCCTGGTGCAGGCTGGGGGCAGCCTGAGCCTGAGCTGTGCCTTCTCTGGCCGCACCTTCTCCATGTACACCATGGGCTGGTTCCGCCAGGCCCCAGGGAAGGAGAGAGAGTTTGTGGCTGCCAACAGAGGCAGAGGCCTGAGCCCAGACATTGCTGACTCTG TGAATGGCCGCTTCACCATCTCCAGAGACAATGCCAAGAACACCCTGTACCTGCAGATGGACAGCCTGAAGCCAGAGGACACAGCTGTGTACTACTGTGCTGCTGACCTGCAGTATGGCAGCAGCTGGCCTCAGAGGAGCTCTGCTGAGTATGACTACTGGGGCCAGGGCACCACTGTGACTGTCTCGAGC

>Sequence ID 267: VH Amino acid sequence of cross-linked αPD-L1

EVQLLESGGGLVQPGGSLRLSCAASGFSFSSGYDMCWVRQAPGKCLEWIACIAAGSAGITYDANWAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARSAFSFDYAMDLWGQGTLVTVSS

>Sequence ID 268: Nucleotide sequence of cross-linked αPD-L1 VH

GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTAGCGGGTACGACATGTGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGATCGCATGCATTGCTGCTGGTAGTGCTGGTATCACTTAC GACGCGAACTGGGCGAAAGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAGATCGGCGTTTTCGTTCGACTACGCCATGGACCTCTGGGGCCAGGGAACCCTGGTCACCGTCTCGTCT

>Sequence ID 269: Amino acid sequence of cross-linked αPD-L1 VL

DIQMTQSPSTLSASVGDRVTITCQASQSISSHLNWYQQKPGKAPKLLIYKASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQQGYSWGNVDNVFGCGTKVEIK

>Sequence ID 270: Nucleotide sequence of cross-linked αPD-L1 VL

GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTCAGAGCATTAGTTCCCACTTAAACTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATAAGGCATCCACTCTGGCAT CTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTTACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAACAGGGTTATAGTTGGGGTAATGTTGATAATGTTTTTCGGCTGCGGGACCAAGGTGGAGATCAAATAG

>Sequence ID 271: Amino acid sequence of cross-linked α4-1BB VH

RSLVESGGGLVQPGGSLRLSCTASGFTISSYHMQWVRQAPGKCLEYIGTISSGGNVYYASSARGRFTISRPSSKNTVDLQMNSLRAEDTAVYYCARDSGYSDPMWGQGTLVTVSS

>Sequence ID 272: Nucleotide sequence of cross-linked α4-1BB VH

CGGTCGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTACTGCCTCTGGATTCACCATCAGTAGCTACCACATGCAGTGGGTCCGGCAGGCACCTGGGAAGTGCCTGGAGTACATCGGAACCATTAGTAGTGGTGGTAATGTATACT ACGCAAGCTCCGCTAGAGGCAGATTCACCATCTCCAGACCCTCGTCCAAGAACACGGTGGATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACTCTGGTTATAGTGATCCTATGTGGGGCCAGGGAACCCTGGTCACCGTCTCTTCA

>Sequence ID 273: Amino acid sequence of cross-linked α4-1BB VL

DVVMTQSPSSVSASVGDRVTITCQASQNIRTYLSWYQQKPGKAPKLLIYAAANLASGVPSRFSGSGSGTDFTLTISDLEPGDAATYYCQSTYLGTDYVGGAFGCGTKVEIK

>Sequence ID 274: Nucleotide sequence of cross-linked α4-1BB VL

GACGTTGTGATGACCCAGTCTCCATCTTCCGTGTCTGCATCTGTAGGAGACAGAGTCACCATCACCTGTCAGGCCAGTCAGAACATTAGGACTTACTTATCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGCTGCAGCCAATCTGGCATCT GGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCGACTTGGAACCTGGCGATGCTGCAACTTACTATTGTCAGTCTACCTATCTTGGTACTGATTATGTTGGCGGTGCTTTCGGCTGTGGGACCAAGGTGGAGATCAAATGA

>Sequence ID 275: Amino acid sequence of cross-linked αHer3 VH

QVQLQESGGGLVKPGGSLRLSCAASGFFSSYWMSWVRQAPGKCLEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVST

>Sequence ID 276: Nucleotide sequence of cross-linked αHer3 VH

CAGGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGTGCCTGGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTAC TATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTGTCGACA

>Sequence ID 277: Amino acid sequence of cross-linked αHer3 VL

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGCGTKVTVL

>Sequence ID 278: Nucleotide sequence of cross-linked αHer3 VL

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAAAGCCCCCAAACTCATGATCTATGATGTCAGTGATC GGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTATTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCTGTGGGACCAAGGTGACCGTCCTA

>Sequence ID 279: Amino acid sequence αCEA 656E11 VH

EVQLVESGGGLVQPGGSLRLSCAASGFSFSGTQYVCWVRQAPGKGLEWIGCIYVDVANTYYATSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASHDTVCAGCGLDLWGQGTLVTVSS

>Sequence ID 280: Nucleotide sequence αCEA 656E11 VH

GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTTATGTGGATGTGGCTAACACTTACTAC GCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGTCATGATACTGTTTGTGCTGGTTGTGGTTTGGACTTGTGGGGCCAGGGAACCCTGGTCACCGTCTCGAGC

>Sequence ID 281: Amino acid sequence of αCEA 656E11 VL

DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQSTYYNNIIYGAAFGGGTKVEIK

>Sequence ID 282: Nucleotide sequence αCEA 656E11 VL

GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGATGCTTCCACTCTGGCAT CTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAATCTACTTATTATAATAATATCATTTATGGGGCTGCTTTCGGCGGAGGGACCAAGGTGGAGATCAAA

>Sequence ID 283: Amino acid sequence of αHER2 VH

EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVST

>Sequence ID 284: Nucleotide sequence of αHER2 VH

GAAGTACAGCTTGTTGAGAGTGGTGGTGGACTTGTCCAACCAGGGGGAAGTCTGCGGCTGTCATGCGCAGCCTCTGGCTTCAACATTAAGGACACCTACATTCACTGGGTTCGGCAAGCGCCGGGGAAGGGGCTGGAATGGGTCGCCAGGATATACCCTACCAACGGGTACACCAGGTAT GCAGATAGCGTTAAGGGTAGATTCACTATTTCAGCTGACACTAGCAAGAACACCGCGTATCTCCAGATGAACTCCCTTCGCGCCGAGGATACGGCTGTGTACTACTGCTCTAGGTGGGGAGGAGATGGGTTTTACGCAATGGATTACTGGGGACAGGGAACACTCGTTACGGTGTCGACA

>Sequence ID 285: Amino acid sequence of αHER2 VL

DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQHYTTPPTFGQGTKVEIK

>Sequence ID 286: Nucleotide sequence of αHER2 VL

GACATCCAAATGACGCAGTCTCCCTCCAGTTTGAGTGCAAGTGTGGGAGACAGAGTTACGATCACATGTAGGGCAAGTCAGGACGTCAATACAGCCGTCGCATGGTACCAGCAGAAGCCTGGAAAGGCCCCGAAACTTCTGATTTACTCTGCAAGTTTCC TCTACAGTGGTGTTCCTAGTCGCTTCAGTGGGTCTCGGTCAGGCACCGATTTTACCCTGACAATTAGCAGCTTGCAACCGGAAGATTTTGCGACCTATTATTGCCAGCAACATTATACCACCCCTCCCACATTTGGACAAGGCACGAAGGTAGAGATTAAA

>Sequence ID 287: Amino acid sequence of SI-20C14 heavy chain (anti-CEA 656E11)

EVQLVESGGGLVQPGGSLRLSCAASGFSFSGTQYVCWVRQAPGKGLEWIGCIYVDVANTYYATSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCASHDTVCAGCGLDLW GQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC DKTHTCPPCPAPEAAGAPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCAVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 288: SI-20C14 heavy chain nucleotide sequence (anti-CEA 656E11)

GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCTCCTTCAGTGGCACCCAGTACGTGTGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGATCGGATGCATTTATGTGGATGTGG CTAACACTTACTACGCGACCTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGTCATGATACTGTTTGTGCTGGTTGTGGTTTGGACTTGTGGGGC CAGGGAACCCTGGTCACCGTCTCGAGCGCTAGCACCAAGGGCCCATCGGTCTTCCCCCTGGCACCCTCCTCCAAGAGCACCTCTGGGGGCACAGCGGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCA GCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACCCAGACCTACATCTGCAACGTGAATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGCCCAAATCTTGTGAC AAAACTCACACATGCCCACCGTGCCCAGCACCTGAAGCCGCGGGGGCACCGTCAGTCTTCCTCTTCCCCCCAAAACCCAAGGACACCCTCATGATCTCCCGGACCCCTGAGGTCACATGCGTGGTGGTGGACGTGAGCCACGAAGACCCTGAGGTCAAGTTCAACTGGT ACGTGGACGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTACAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAATGGCAAGGAGTACAAGTGCGCGGTCTCCAACAAAGCCCTCCCAGCCCCCATCGAGAAA ACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAACCACAGGTGTACACCCTGCCCCCATCCCGGGATGAGCTGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTATCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACT ACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTATAGCAAGCTCACCGTGGACAAGAGCAGGTGGCAGCAGGGGAACGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACGCAGAAGAGCCTCTCCCTGTCTCCGGGTTAA

>Sequence ID 289: Amino acid sequence of SI-20C14 light chain (anti-CEA 656E11)

DIQMTQSPSTLSASVGDRVTITCQASENIYSNLAWYQQKPGKAPKLLIYDASTLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQSTYYNNIIYGAAFGGGTKVE IKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC

>Sequence ID 290: SI-20C14 light chain nucleotide sequence (anti-CEA 656E11)

GACATCCAGATGACCCAGTCTCCTTCCACCCTGTCTGCATCTGTAGGAGACAGAGTCACCATCACTTGCCAGGCCAGTGAGAACATTTACAGCAATTTAGCCTGGTATCAGCAGAAACCAGGGAAAGCCCCTAAGCTCCTGATCTATGATGCTTCCACTCTGGC ATCTGGGGTCCCATCAAGGTTCAGCGGCAGTGGATCTGGGACAGAATTCACTCTCACCATCAGCAGCCTGCAGCCTGATGATTTTGCAACTTATTACTGCCAATCTACTTATTATAATAATATCATTTATGGGGCTGCTTTCGGCGGAGGGACCAAGGTGGAGA TCAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAG GAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG

>Sequence ID 291: Amino acid sequence of αCD3***** VH

QQLVESGGGLVKPGGSLRLSCAASGIDLSSNAIGWVRQAPGKGLEWVGVIFGSGNTYYASWAKGRFTISRSKNTVYLQMNSLRAEDTAVYYCARGGYSSDIWGQGTLVTVSS

>Sequence ID 292: Nucleotide Sequence αCD3***** VH

CAACAGTTGGTTGAGTCTGGTGGCGGTCTCGTTAAGCCTGGAGGGTCCCTTCGGCTTAGTTGTGCGGCCTCTGGGATCGACCTGTCTAGCAACGCTATAGGATGGGTACGGCAAGCTCCGGGCAAAGGCCTTGAGTGGGTCGGCGTTATTTTTGGGAGCGGTAATACG TACTACGCCAGCTGGGCAAAAGGTAGGTTCACTATCAGTCGATCAAAGAACACGGTATATCTTCAGATGAACAGTCTCCGGGCGGAGGACACCGCGGTTTATTATTGCGCAAGGGGGGGATACTCCTCAGACATATGGGGCCAAGTACTTTGGTGACGGTCTCGAGC

>Sequence ID 293: Amino acid sequence of αCD3***** VL

DPVLTQSPSSLSSASVGDRVTISCQSSQSVAKNNNLAWFQQKPGQAPKLLIYSASTLAAGVPSRFSGSGSGTDFTLTISSVQPEDFATYYCSARDSGNIQSFGGGTKVEIK

>Sequence ID 294: Nucleotide Sequence αCD3***** VL

GATCCAGTTCTGACACAAAGTCCATCCAGCCTGTCTGCCTCAGTCGGCGACAGAGTGACCATCAGTTGCCAGAGCTCACAGTCTGTGGCTAAGAACAACAACTTGGCGTGGTTCCAACAGAAACCTGGACAGGCTCCGAAATTGCTGATCTATTCTGCTTCCACG CTTGCTGCTGGTGTTCCTTCCCGCTTTTCAGGTAGTGGTAGCGGGACAGACTTCACTTTGACTATAAGCAGCGTGCAGCCTGAAGATTTTGCGACCTACTATTGTTCTGCTAGAGACAGTGGAAATTTCAGTCCTTTGGGGGGGGAACGAAGGTCGAAATAAAG

>Sequence ID 295: Amino acid sequence of NKG2D monomer

FLNSLFNQEVQIPLTESYCGPCPKNWICYKNNCYQFFDESKNWYESQASCMSQNASLLKVYSKEDQDLLKLVKSYHWMGLVHIPTNGSWQWEDGSILSPNLLTIIEMQKGDCALYASSFKGYIENCSTPNTYICMQRTV

>Sequence ID 296: Nucleotide sequence of NKG2D monomer

TTTCTGAATAGCCTGTTCAACCAGGAGGGTGCAGATCCCACTGACCGAGAGCTATTGTGGACCTTGTCCTAAGAACTGGATCTGTTACAAGAACAACTGCTACCAGTTCTTCGACGAGAGCAAGAATTGGTATGAAAGCCAGGCCAGCTGCATGAGCCAAAACGCCTCTCTGCTGAAGGTGTACTCCAAAGAAGATCAGGACCTGCTGA AGCTGGTGAAGTCCTACCACTGGATGGGCCTGGTGCACATCCCAACCAACGGCAGCTGGCAGTGGGAAGACGGCAGCATCCTGAGCCCTAACCTGCTGACAATCATTGAGATGCAGAAAGGCGACTGCGCCCTGTACGCCAGTTCTTTTAAGGGCTACATCGAAAACTGTAGCACCCCTAACACCTACATCTGCATGCAGAGAACAGTG

>Sequence ID 297: Amino acid sequence of chain A of SI-75XM9

QVQLQESGGRLVQPGEPLSLTCKTSGIDLSSNAIGWVRQAPGKGLEWIGVIFGSGNTYYASWAKGRFTISRSTSTVYLKMNSLRSEDTAIYYCARGGYSSDIWGQGTLV TVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPC PPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTI SKAKGQPREPQVYTLPPSQEEMTKNQVSLSCAVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLVSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG

>Sequence ID 298: Nucleotide sequence of chain A SI-75XM9

CAAGTGCAGTTGCAAGAAAGTGGTGGTAGACTGGTTCAGCCTGGTGAACCCTTGTCACTGACGTGTAAAACAAGCGGCATTGATCTGTCCTCTAACGCCATCGGATGGGTCCGACAGGCCCCAGGAAAAGGTCTGGAGTGGATCGGAGTTATCTTCGGGAGCGGC AATACATACTACGCAAGCTGGGCAAAAGGGCGATTTACGATATCACGGAGCACCTCTACAGTTTATTTGAAAATGAACTCCCTCCGGTCCGAGGATACCGCGATATATTACTGTGCCAGAGGGGGGTACTCCTCTGATATCTGGGGGCAGGGTACACTGGTTACA GTTTCATCCGCTAGCACCAAGGGACCCTCTGTGTTTCCTCTGGCTCCTTGCTCCAGATCCACCTCCGAGTCTACAGCTGCTCTGGGCTGCCTGGTCAAGGACTACTTTCCTGAGCCTGTGACCGTGTCCTGGAACTCTGGCGCTCTGACATCTGGCGTGCACACC TTTCCAGCTGTGCTGCAGTCCTCCGGCCTGTACTCTCTGTCCTCTGTCGTGACCGTGCCTTCCTCTAGCCTGGGCACCAAGACCTACACCTGTAATGTGGACCACAAGCCTTCCAACACCAAGGTGGACAAGCGCGTGGAATCTAAGTACGGCCCTCCTTGTCCT CCATGTCCTGCTCCAGAAGCTGCTGGCGGCCCATCCGTGTTTCTGTTCCCTCCAAAGCCTAAGGACACCCTGATGATCTCTCGGACCCCTGAAGTGACCTGCGTGGTGGTGGATGTGTCCCAAGAGGATCCCGAGGTGCAGTTCAATTGGTACGTGGACGGCGTG GAAGTGCACAACGCCAAGACCAAGCCTAGAGAGGAACAGTTCAACTCCACCTACAGAGTGGTGTCCGTGCTGACCGTGCTGCACCAGGATTGGCTGAACGGCAAAGAGTACAAGTGCAAGGTGTCCAACAAGGGCCTGCCTTCCAGCATCGAAAAGACCATCTCC AAGGCCAAGGGCCAGCCTAGGGAACCCCAGGTTTACACCCTGCCTCCAAGCCAAGAGGAAATGACCAAGAACCAGGTGTCCCTGTCCTGCGCCGTGAAGGGCTTCTACCCTTCCGATATCGCCGTGGAATGGGAGAGCAATGGCCAGCCTGAGAACAACTACAAG ACAACCCCTCCTGTGCTGGACTCCGACGGCTCCTTCTTCCTGGTGTCCCGCCTGACCGTGGACAAGTCCAGATGGCAAGAGGGCAACGTGTTCTCCTGCTCCGTGATGCACGAGGCCCTGCACAATCACTACACCCAGAAGTCCCTGTCTCTGTCCCTGGGATGA

>Sequence ID 299: Amino acid sequence of chain B of SI-75XM9

QSALTQPASVSGSPGQSITISCTGTSSDVGGYNFVSWYQQHPGKAPKLMIYDVSDRPSGVSDRFSGSKSGNTASLIISGLQADDEADYYCSSYGSSSTHVIFGGGTKVTVLGGGGSGGGGSGGGGSGGGGSQVQLQESGGGLVKPGGSLSLSCAASGFTFSSYWMSWVRQAPGKG LEWVANINRDGSASYYVDSVKGRFTISRDDAKNSLYLQMNSLRAEDTAVYYCARDRGVGYFDLWGRGTLVTVSSGGGGSGGGGSDPQLTQSPSSLSATVGQRVTINCQSSQSVAKNNNLAWFQQKPGKPPKLLIYSASTLAAGVPSRFSGSGSGTQFTLTITRVQSEDFATYYCSA RDSGNIQSFGGGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECGGGPPCPPCPAPEAAGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQED PEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEM TKNQVSLWCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNRFTQKSLSLSLG

>Sequence ID 300: Nucleotide sequence of chain B of SI-75XM9

CAGTCTGCCCTGACTCAGCCTGCCTCCGTGTCTGGGTCTCCTGGACAGTCGATCACCATCTCCCTGCACTGGAACCAGCAGTGACGTTGGTGGTTATAACTTTGTCTCCTGGTACCAACAACACCCAGGCAA AGCCCCCAAACTCATGATCTATGATGTCAGTGATCGGCCCTCAGGGGTGTCTGATCGCTTCTCCGGCTCCAAGTCTGGCAACACGGCCTCCCTGATCATCTCTGGCCTCCAGGCTGACGACGAGGCTGATTA TTACTGCAGCTCATATGGGAGCAGCAGCACTCATGTGATTTTCGGCGGAGGGACCAAGGTGACCGTCCTAGGCGGTGGCGGTAGTGGGGGAGGCGGTTCTGGCGGCGGAGGGTCCGGCGGTGGAGGATCACA GGTGCAATTGCAGGAGTCGGGGGGAGGCCTGGTCAAGCCTGGAGGGTCCCTGAGCCTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGTTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCT GGAGTGGGTGGCCAACATAAACCGCGATGGAAGTGCGAGTTACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACGACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCTG AGGACACGGCTGTGTATTACTGTGCGAGAGATCGTGGGGTGGGCTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACCGTCTCGAGTGGCGGTGGAGGGTCCGGCGGTGGTGGATCAGATCCTCAATTGA CCCAGTCCCCTAGTAGCCTTTCTGCAACCGTGGGCCAGAGGGTAACAATCAATTGCCAGTCAAGCCAGTCCGTAGCGAAGAATAATAATTTGGCATGGTTCCAACAAAAACCGGGTAAACCTCCTAAACTCC TTATCTACTCAGCTTCAACCCTTGCCGCGGGTGTGCCCAGCCGGTTCTCAGGCTCAGGTTCCGGGACTCAATTTACACTTACCATCACTCGCGTCCAAAGTGAGGATTTTGCAACCTACTATTGTTCTGCAC GGGATTCCGGGAACATACAGTCCTTTGGGGGTGGAACTCGGGTGGAGATAAAACGTACGGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTG TGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGC ACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTACGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTGGCGGCGGACCTCCTTGTCCT CCATGTCCTGCTCCAGAAGCTGCTGGCGGCCCATCCGTGTTTCTGTTCCCTCCAAAGCCTAAGGACACCCTGATGATCTCTCGGACCCCTGAAGTGACCTGCGTGGTGGTGGATGTGTCCCAAGAGGATCCC GAGGTGCAGTTCAATTGGTACGTGGACGGCGTGGAAGTGCACAACGCCAAGACCAAGCCTAGAGAGGAACAGTTCAACTCCACCTACAGAGTGGTGTCCGTGCTGACCGTGCTGCACCAGGATTGGCTGAAC GGCAAAGAGTACAAGTGCAAGGTGTCCAACAAGGGCCTGCCTTCCAGCATCGAAAAGACCATCTTCCAAGGCCAAGGGCCAGCCTAGGGAACCCCAGGTTTACACCCTGCCTCCAAGCCAAGAGGAAATGACC AAGAACCAGGTGTCCCTGTGGTGCCTCGTGAAGGGCTTCTACCCTTCCGATATCGCCGTGGAATGGGAGAGCAATGGCCAGCCTGAGAACAACTACAAGACAACCCCTCCTGTGCTGGACTCCGACGGCTCC TTCTTCCTGTATTCCCGCCTGACCGTGGACAAGTCCAGATGGCAAGAGGGCAACGTGTTCTCCTGCTCCGTGATGCACGAGGCCCTGCACAATCGCTTCACCCAGAAGTCCCTGTCTCTGTCCCTGGGATGA

>Sequence ID 301: CDR-H1 amino acid sequence of anti-CEA 656E11

GTQYVC

>Sequence ID 302: amino acid sequence of CDR-H2 of anti-CEA 656E11

CIYVDVANTYYATSVKG

>Sequence ID 303: amino acid sequence of CDR-H3 of anti-CEA 656E11

HDTVCAGCGLDL

>Sequence ID 304: amino acid sequence of CDR-L1 of anti-CEA 656E11

QASENIYSNLA

>Sequence ID 305: amino acid sequence of CDR-L2 of anti-CEA 656E11

DASTLAS

>Sequence ID 306: amino acid sequence of CDR-L3 of anti-CEA 656E11

QSTYYNNIIYGAA

>Sequence ID 307: amino acid sequence of CDR-H1 anti-CD3 283E3 (BSM/FRS)

SNAIG

>Sequence ID 308: amino acid sequence of CDR-H2 anti-CD3 283E3 (BSM/FRS)

VIFGSGNTYYASWAKG

>Sequence ID 309: amino acid sequence of CDR-H3 anti-CD3 283E3 (BSM/FRS)

GGYSSDI

>Sequence ID 310: amino acid sequence of CDR-L1 anti-CD3 283E3 (BSM/FRS)

QSSQSVAKNNNLA

>Sequence ID 311: amino acid sequence of CDR-L2 anti-CD3 283E3 (BSM/FRS)

SASTLAA

>Sequence ID 312: amino acid sequence of CDR-L3 anti-CD3 283E3 (BSM/FRS)

SARDSGNIQS

>Sequence ID 313: Amino acid sequence of human IgG1

ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDG VEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG

>Sequence ID 314: Amino acid sequence of human IgG4

ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPSCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLG

--->

LIST OF SEQUENCES

<110> SYSTEMUNE, INC.

BAILI-BAYO (CHENGDU) PHARMACEUTICAL CO., LTD.

<120> MINIATURE ANTIBODY-LIKE PROTEINS FOR CONTROL AND NAVIGATION

CONTROL (miniGNC) AND METHODS OF THEIR OBTAINING AND APPLICATION

<130>SIBA068PCT

<150> 62/991,042

<151> 2020-03-17

<160> 314

<170> PatentIn version 3.5

<210> 1

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 1

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 2

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 2

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctgga 1326

<210> 3

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 3

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys

465 470 475 480

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

485 490 495

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

500 505 510

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

515 520 525

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

530 535 540

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

545 550 555 560

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

565 570 575

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

580 585 590

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

595 600 605

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp

610 615 620

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

625 630 635 640

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

645 650 655

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

660 665 670

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

675 680 685

Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695 700

<210> 4

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 4

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1920

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040

ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100

ctgagccctg ga 2112

<210> 5

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 5

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 6

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 6

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctgga 1326

<210> 7

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 7

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys

465 470 475 480

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

485 490 495

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

500 505 510

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

515 520 525

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

530 535 540

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

545 550 555 560

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

565 570 575

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

580 585 590

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

595 600 605

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp

610 615 620

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

625 630 635 640

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

645 650 655

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

660 665 670

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

675 680 685

Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695 700

<210> 8

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 8

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1920

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040

ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100

ctgagccctg ga 2112

<210> 9

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 9

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 10

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 10

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctgga 1326

<210> 11

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 11

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys

465 470 475 480

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

485 490 495

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

500 505 510

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

515 520 525

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

530 535 540

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

545 550 555 560

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

565 570 575

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

580 585 590

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

595 600 605

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp

610 615 620

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

625 630 635 640

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

645 650 655

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

660 665 670

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

675 680 685

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695 700

<210> 12

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 12

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1920

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040

ttctcctgct ctgtcatgca tgaggccctg cacaaccact acacccagaa gagcctgagc 2100

ctgagccctg ga 2112

<210> 13

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 13

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 14

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 14

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctgga 1326

<210> 15

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 15

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys

465 470 475 480

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

485 490 495

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

500 505 510

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

515 520 525

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

530 535 540

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

545 550 555 560

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

565 570 575

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

580 585 590

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

595 600 605

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp

610 615 620

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

625 630 635 640

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

645 650 655

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

660 665 670

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

675 680 685

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695 700

<210> 16

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 16

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1920

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040

ttctcctgct ctgtcatgca tgaggccctg cacaaccact acacccagaa gagcctgagc 2100

ctgagccctg ga 2112

<210> 17

<211> 967

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 17

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val

130 135 140

Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr

145 150 155 160

Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly

165 170 175

Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala

180 185 190

Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn

195 200 205

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn

225 230 235 240

Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

245 250 255

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly

260 265 270

Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly

275 280 285

Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly

290 295 300

Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp

305 310 315 320

Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser

325 330 335

Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr

340 345 350

Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe

355 360 365

Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr

370 375 380

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser

385 390 395 400

Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu

405 410 415

Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His

420 425 430

Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser

435 440 445

Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys

450 455 460

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu

465 470 475 480

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

485 490 495

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

500 505 510

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

515 520 525

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

530 535 540

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

545 550 555 560

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

565 570 575

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

580 585 590

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

595 600 605

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

610 615 620

Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp

625 630 635 640

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

645 650 655

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser

660 665 670

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

675 680 685

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

690 695 700

Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

705 710 715 720

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly

725 730 735

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr

740 745 750

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

755 760 765

Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

770 775 780

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro

785 790 795 800

Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp

805 810 815

Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

835 840 845

Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln

850 855 860

Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile

865 870 875 880

Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

885 890 895

Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser

900 905 910

Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr

915 920 925

Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr

930 935 940

Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly

945 950 955 960

Thr Leu Val Thr Val Ser Ser

965

<210> 18

<211> 2901

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 18

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360

ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420

ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480

atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540

ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600

atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660

gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720

atttggggcc agggaaccct ggtcaccgtc tcgagtggcg gtggagggtc cggcggtggt 780

ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840

agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900

caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960

tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020

tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080

ctgacctact acgattacga atttgcgtat tggggggcaag ggactcttgt aacagtctcc 1140

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740

aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800

tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860

gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100

acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160

gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220

attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280

ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340

cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400

ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460

gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520

tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580

ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640

agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700

acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760

tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820

acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880

acattggtta ccgtgtcctc t 2901

<210> 19

<211> 963

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 19

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val

260 265 270

Ser Pro Gly Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile

275 280 285

Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg

290 295 300

Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Val Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn

340 345 350

Trp Pro Thr Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr

355 360 365

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

370 375 380

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

385 390 395 400

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

405 410 415

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

420 425 430

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

435 440 445

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

450 455 460

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

465 470 475 480

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

485 490 495

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

500 505 510

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

515 520 525

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

530 535 540

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

545 550 555 560

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

565 570 575

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

580 585 590

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

595 600 605

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

610 615 620

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

625 630 635 640

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

645 650 655

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

660 665 670

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

675 680 685

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly

690 695 700

Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser

705 710 715 720

Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala

725 730 735

Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly

740 745 750

Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly

755 760 765

Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu

770 775 780

Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln

785 790 795 800

Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr

805 810 815

Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser

835 840 845

Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala

850 855 860

Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg

865 870 875 880

Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly

885 890 895

Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr

900 905 910

Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser

915 920 925

Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe

930 935 940

Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr

945 950 955 960

Val Ser Ser

<210> 20

<211> 2892

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 20

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagaa 780

atcgtcctta cacaatctcc tagcacactg agtgtgagcc ccggcgaacg cgcgactttc 840

tcttgcaggg caagtcaatc catagggact aatatacatt ggtatcaaca aaagccaggt 900

aaaccaccca ggcttttgat taagtatgca agtgagtcta tttccggtat ccctgaccgc 960

ttctctggat caggcagtgg cacagagttc acactcacca tatctagtgt gcaatcagag 1020

gacttcgccg tgtattactg ccaacagaat aataactggc cgactacctt cggacccggt 1080

acaaagctga ccgttttacg tacggtggct gcaccatctg tcttcatctt cccgccatct 1140

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc 1200

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 1260

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg 1320

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 1380

agctcgcccg tcacaaagag cttcaacagg ggagagtgtg gaggcgacaa aactcacaca 1440

tgcccaccgt gcccagcacc tgaagccgcg gggggaccgt cagtcttcct cttcccccca 1500

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac 1560

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat 1620

aatgccaaga caaagccgcg ggagggagcag tacaacagca cgtaccgtgt ggtcagcgtc 1680

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcgc ggtctccaac 1740

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa 1800

ccacaggtgt acaccctgcc cccaagccgg gatgagctga ccaagaacca ggtcagcctg 1860

tggtgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg 1920

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc 1980

ctctatagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc 2040

tccgtgatgc atgaggctct gcacaacaga ttcacgcaga agagcctctc cctgtctccg 2100

ggtggcggtg gagggtccgg cggtggtgga tccgacattc agatgacaca gtcaccgtct 2160

acgctctcag cctcagtagg cgatagggtg actatcacct gccaagcctc ccaatctata 2220

agttcacacc tcaactggta tcaacagaaa cccggtaaag caccgaagct gctcatctac 2280

aaggcatcaa ctcttgcctc aggtgtgcct agtcgcttct ccgggagcgg ctccggtact 2340

gagtttactt tgacgatatc ttccctccaa cccgacgact tcgccacata ctattgtcag 2400

cagggttata gttggggaaa tgttgacaat gtgtttggag ggggaacgaa agtgactgtg 2460

ttgggagggg gaggaagtgg cggcggcgga agcggaggtg gtggctccgg cggggggtgga 2520

agcgaagtgc aattgctcga aagtggtggc ggacttgtgc aacctggtgg aagcctctca 2580

ctctcttgcg cggcgagtgg ttttagcttc agtagcggct acgatatgtg ctgggtaaga 2640

caggctcctg gtaaaggcct tgagtggatt gcgtgtatcg ccgccgggtc tgctggtata 2700

acatacgatg caaactgggc gaaagggcgc ttcacaatct ccagggacaa ctcaaaaaat 2760

acattgtacc tccagatgaa tagcctgaga gccgaagaca ccgcagtcta ctattgcgca 2820

aggtcagcat ttagcttcga ttatgcaatg gatctttggg gccaggggac gctcgtcacc 2880

gtctcatcttga 2892

<210> 21

<211> 1277

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 21

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu

705 710 715 720

Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met

725 730 735

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu

740 745 750

Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly

755 760 765

Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly

770 775 780

Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly

785 790 795 800

Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg

805 810 815

Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro

820 825 830

Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu

835 840 845

Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu

850 855 860

Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu

865 870 875 880

Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly Ser Thr

885 890 895

Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Arg

900 905 910

Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu

915 920 925

Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile

930 935 940

Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser

945 950 955 960

Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val

965 970 975

Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg

980 985 990

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His Leu

995 1000 1005

Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr

1010 1015 1020

Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe

1025 1030 1035

Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu

1040 1045 1050

Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln

1055 1060 1065

Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro

1070 1075 1080

Glu Ile Pro Ala Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly

1085 1090 1095

Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu

1100 1105 1110

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn

1115 1120 1125

Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly

1130 1135 1140

Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp

1145 1150 1155

Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

1160 1165 1170

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly

1175 1180 1185

Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala

1190 1195 1200

Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser

1205 1210 1215

Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu

1220 1225 1230

His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu

1235 1240 1245

Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

1250 1255 1260

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu

1265 1270 1275

<210> 22

<211> 3834

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 22

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatcccgaga gggccccgag 2160

ctgtctcctg atgacccagc aggcctcttg gacttgcggc agggtatgtt cgctcaactt 2220

gtggctcaga atgttctgct cattgatgga ccactctctt ggtatagtga ccccggtctg 2280

gccggggtga gtctgaccgg cgggctctct tataaagagg atactaagga actggtcgta 2340

gcaaaagcgg gcgtttatta cgtttttttt cagctggagc tcaggcgcgt ggtggccggc 2400

gagggcagtg gctctgtgtc cctggccctg cacttacagc ccttgagaag cgctgcaggt 2460

gctgccgcac tggctttaac tgttgacctc cctccggcct cttctgaagc tagaaacagc 2520

gctttcggct tccaagggcg cctgctgcac ctgagcgcag gccagcgctt aggtgtgcac 2580

cttcatacag aggccagggc ccgacacgct tggcagctca cacagggtgc cacggttctc 2640

ggacttttcc gcgttactcc cgagatcccc gctggcctcg gaagtactgg ttctgggtct 2700

aaacccggtt ccggcgaagg tagtactaaa ggacgagaag ggccagagtt aagtccagat 2760

gaccctgctg ggcttttgga cctgcggcag ggcatgttcg ctcaactggt ggctcagaac 2820

gtgctgctga tcgatggccc cctgagttgg tacagcgatc ccgggctggc aggcgtgtca 2880

cttacagggg gcctctctta caaggaagac accaaggagt tagtggtcgc taaggctggc 2940

gtgtattacg tgttcttcca actggagctg agaagggttg tggcaggaga gggtagcggc 3000

agcgtgtctt tagcccttca cttgcagccc ctgaggtctg ctgcaggtgc agccgctctc 3060

gcgctcaccg tggatctccc cccagcctca tctgaagcta ggaacagtgc atttggcttt 3120

cagggacgct tgctgcacct ctccgctgga cagaggctgg gcgtgcacct tcacacagag 3180

gcccgtgcca ggcatgcatg gcagctcact cagggggcaa cagtgctggg tctcttccgc 3240

gtgactcctg aaataccagc tggacttggc ggtggaggca gcggcggagg aggatctcgt 3300

gaggggccag aactgtcccc cgatgaccca gccggactgc tcgatctcag acagggcatg 3360

ttcgctcagc ttgtagccca aaatgtcctc ctgattgacg gccctttgag ctggtatagt 3420

gatcccggct tggccggggt atctctgacc ggaggcctct cctacaagga agacaccaaa 3480

gagctggtgg tggcaaaagc gggggtgtat tatgtgttct ttcagctcga gctgcggaga 3540

gttgtggccg gggaagggtc tgggagcgta tctcttgcac ttcacctgca gcccctgcgc 3600

agcgccgctg gagccgccgc ccttgctctt actgtggatc tgcctcctgc ttcctcagaa 3660

gcacgcaaca gcgccttcgg ctttcaagga cgtctcctgc acttgtccgc aggacagagg 3720

ttgggcgtcc atttacacac tgaggcacgg gcacggcacg cttggcagct tacccaggga 3780

gccaccgtgc tgggactctt tagagtgaca cccgagatcc ccgctggctt gtga 3834

<210> 23

<211> 968

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 23

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met

705 710 715 720

Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr

725 730 735

Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr

740 745 750

Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser

755 760 765

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly

770 775 780

Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala

785 790 795 800

Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val

805 810 815

Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp

865 870 875 880

Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala

885 890 895

Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala

900 905 910

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

915 920 925

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

930 935 940

Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln

945 950 955 960

Gly Thr Leu Val Thr Val Ser Ser

965

<210> 24

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 24

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100

ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160

acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220

gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280

aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340

agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400

acatactatt gtcagcagg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460

acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520

tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580

ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640

atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700

gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760

gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820

gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880

gggacgctcg tcaccgtctc atcttga 2907

<210> 25

<211> 962

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 25

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr

705 710 715 720

Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile

725 730 735

Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln

740 745 750

Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn

755 760 765

Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

770 775 780

Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr

785 790 795 800

Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala

805 810 815

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met

865 870 875 880

Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr

885 890 895

Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg

900 905 910

Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp

930 935 940

Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val

945 950 955 960

Ser Ser

<210> 26

<211> 2886

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 26

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160

cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220

agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280

ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340

ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400

tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460

acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520

tctggggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580

ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640

caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700

ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760

aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820

tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880

tccctct 2886

<210> 27

<211> 968

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 27

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met

705 710 715 720

Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr

725 730 735

Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr

740 745 750

Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser

755 760 765

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly

770 775 780

Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala

785 790 795 800

Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val

805 810 815

Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp

865 870 875 880

Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala

885 890 895

Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala

900 905 910

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

915 920 925

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

930 935 940

Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln

945 950 955 960

Gly Thr Leu Val Thr Val Ser Ser

965

<210> 28

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 28

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100

ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160

acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220

gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280

aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340

agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400

acatactatt gtcagcagg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460

acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520

tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580

ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640

atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700

gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760

gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820

gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880

gggacgctcg tcaccgtctc atcttga 2907

<210> 29

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 29

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr

275 280 285

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

290 295 300

Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val

305 310 315 320

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr

325 330 335

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

340 345 350

Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr

355 360 365

Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro

370 375 380

Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly

385 390 395 400

Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn

405 410 415

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln

420 425 430

Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser

435 440 445

Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser

450 455 460

Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys

610 615 620

Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly

690 695 700

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser

705 710 715 720

Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

725 730 735

Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys

740 745 750

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala

755 760 765

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe

770 775 780

Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr

785 790 795 800

Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly

805 810 815

Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly

820 825 830

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu

835 840 845

Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu

850 855 860

Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp

865 870 875 880

Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr Ile Ser

885 890 895

Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr

900 905 910

Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser

915 920 925

Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly

930 935 940

Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 30

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 30

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaca ggtgcagctg 780

caggagagtg gaggaggcct ggtgaagcct ggaggcagcc tgcggctgtc ctgtgctgcc 840

tctggcttca ccttctcctc ctactggatg agctgggtgc gccaggcccc aggcaagggc 900

ctggagtggg tggccaacat caacagagat ggctctgcct cctactatgt ggactctgtg 960

aaaggccgct tcaccatctc cagagatgat gccaagaaca gcctgtacct gcagatgaac 1020

agcctgagag ctgaggacac agctgtgtac tactgtgcca gagaccgagg tgtgggctac 1080

tttgacctgt ggggcagagg caccctggtg actngtgtcct ctgctagcac caagggccca 1140

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 1200

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 1260

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 1320

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 1380

cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtatac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1860

agcctgtcct gcgccgtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 2100

tctccgggtg gcggcggcgg ttcaggtggt gggggatccg acgttgtgat gacgcagtct 2160

cctagttcag tatcagcgtc tgttggggat cgagtcacga ttacatgcca ggcgagccaa 2220

aatattagga cgtatctgtc ttggtatcaa caaaagcctg gtaaggctcc aaaactcctc 2280

atttacgccg ctgccaactt ggctagtgga gtaccttcac gctttagtgg gtcaggttct 2340

ggaacagatt ttacgttgac gatctccgat ttggaaccag gggacgctgc cacgtattat 2400

tgccagtcca cctacctcgg gactgactac gttggtgggg cgtttggcgg aggaacaaaa 2460

ctcactgtac ttggtggtgg tggttcaggc ggggggggtt ccggcggagg cggttctggg 2520

ggtggaggtt ccgaggttca gttggttgaa agtggggggg gactcgttca gcctggaggc 2580

tctttgcgac tttcttgtac cgcttctggg ttcactataa gttcatatca tatgcaatgg 2640

gtaagacagg cgcctggtaa gggacttgaa tacataggaa caataagctc tggtggtaac 2700

gtctattacg cctcatccgc gcgggggagg tttacaattt ccaggccttc tagcaaaaac 2760

acggtagatc tgcaaatgaa ctctcttcgc gctgaagata cagcagtcta ctactgcgcc 2820

agggattcag ggtattctga ccccatgtgg gggcagggca cattggttac cgtgtcctct 2880

tga 2883

<210> 31

<211> 969

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 31

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val

130 135 140

Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr

145 150 155 160

Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly

165 170 175

Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala

180 185 190

Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn

195 200 205

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn

225 230 235 240

Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

245 250 255

Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val

260 265 270

Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser

275 280 285

Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro

290 295 300

Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser

305 310 315 320

Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser

325 330 335

Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys

340 345 350

Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr

355 360 365

Lys Val Thr Val Leu Arg Thr Pro Lys Ala Asn Pro Thr Val Thr Leu

370 375 380

Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val

385 390 395 400

Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys

405 410 415

Ala Asp Gly Ser Pro Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser

420 425 430

Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr

435 440 445

Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His

450 455 460

Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser Gly

465 470 475 480

Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala

485 490 495

Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu

500 505 510

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser

515 520 525

His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu

530 535 540

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr

545 550 555 560

Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn

565 570 575

Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro

580 585 590

Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln

595 600 605

Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val

610 615 620

Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val

625 630 635 640

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro

645 650 655

Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr

660 665 670

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val

675 680 685

Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu

690 695 700

Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln

705 710 715 720

Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val

725 730 735

Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp

740 745 750

Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala

755 760 765

Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser

770 775 780

Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe

785 790 795 800

Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn

805 810 815

Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser

820 825 830

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu

835 840 845

Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser

850 855 860

Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr

865 870 875 880

Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

885 890 895

Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp

900 905 910

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu

915 920 925

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

930 935 940

Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly

945 950 955 960

Gln Gly Thr Leu Val Thr Val Ser Ser

965

<210> 32

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 32

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360

ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420

ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480

atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540

ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600

atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660

gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720

atttggggcc agggaaccct ggtcaccgtg tcctcaggcg gtggagggtc cggcggtggt 780

ggatcacaga gtgccctgac ccagccagcc tctgtctctg gcagcccagg ccagtccatc 840

accatctcct gcacaggcac ctccagtgat gtgggaggct acaactttgt gtcctggtac 900

cagcagcacc caggcaaggc ccccaagctc atgatctatg atgtgtctga cagaccctct 960

ggagtctctg acagattctc tggctccaag agtggcaaca cagcctccct catcatctct 1020

ggcctgcagg ctgatgatga agctgactac tactgctcct cctatggctc ctcctccacc 1080

catgtcatct ttggaggagg caccaaggtc actgtgctgc gtacgcccaa ggccaacccc 1140

accgtgaccc tgttcccccc aagcagcgag gaactgcagg ccaacaaggc caccctcgtg 1200

tgcctgatca gcgacttcta ccctggcgcc gtgaccgtgg cctggaaggc cgatggatct 1260

cccgtgaagg ccggcgtgga aaccaccaag cccagcaagc agagcaacaa caaatacgcc 1320

gccagctcct acctgagcct gacccccgag cagtggaagt cccaccggtc ctacagctgc 1380

caggtcacac acgaaggcag caccgtggaa aagacagtgg cccccaccga gtgcagcgga 1440

ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg gggaccgtca 1500

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 1560

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 1620

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 1680

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caagggagtac 1740

aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1800

aaagggcagc cccgagaacc acaggtgtac accctgcccc caagccggga tgagctgacc 1860

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg 1920

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1980

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 2040

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaacagatt cacgcagaag 2100

agcctctccc tgtctccggg tggcggtgga gggtccggcg gtggtggatc cgacattcag 2160

atgacacagt caccgtctac gctctcagcc tcagtaggcg atagggtgac tatcacctgc 2220

caagcctccc aatctataag ttcacacctc aactggtatc aacagaaacc cggtaaagca 2280

ccgaagctgc tcatctacaa ggcatcaact cttgcctcag gtgtgcctag tcgcttctcc 2340

gggagcggct ccggtactga gtttactttg acgatatctt ccctccaacc cgacgacttc 2400

gccacatact attgtcagca gggttatagt tggggaaatg ttgacaatgt gtttggaggg 2460

ggaacgaaag tgactgtgtt gggaggggga ggaagtggcg gcggcggaag cggaggtggt 2520

ggctccggcg ggggtggaag cgaagtgcaa ttgctcgaaa gtggtggcgg acttgtgcaa 2580

cctggtggaa gcctctcact ctcttgcgcg gcgagtggtt ttagcttcag tagcggctac 2640

gatatgtgct gggtaagaca ggctcctggt aaaggccttg agtggattgc gtgtatcgcc 2700

gccgggtctg ctggtataac atacgatgca aactgggcga aagggcgctt cacaatctcc 2760

agggacaact caaaaaatac attgtacctc cagatgaata gcctgagagc cgaagacacc 2820

gcagtctact attgcgcaag gtcagcattt agcttcgatt atgcaatgga tctttggggc 2880

caggggacgc tcgtcaccgt ctcatct 2907

<210> 33

<211> 962

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 33

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr

705 710 715 720

Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile

725 730 735

Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln

740 745 750

Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn

755 760 765

Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

770 775 780

Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr

785 790 795 800

Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala

805 810 815

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met

865 870 875 880

Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr

885 890 895

Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg

900 905 910

Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp

930 935 940

Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val

945 950 955 960

Ser Ser

<210> 34

<211> 2889

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 34

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160

cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220

agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280

ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340

ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400

tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460

acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520

tctggggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580

ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640

caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700

ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760

aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820

tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880

tcctcttga 2889

<210> 35

<211> 706

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 35

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly

705

<210> 36

<211> 2121

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 36

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140

atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200

aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260

ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320

tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380

acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440

gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500

ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560

tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620

ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680

cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740

tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800

ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860

aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920

tggggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980

gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040

aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100

ctgagcctga gccctggatg a 2121

<210> 37

<211> 705

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 37

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly

705

<210> 38

<211> 2118

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 38

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140

ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200

ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260

gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320

ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380

gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440

aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620

gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860

caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980

ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100

agcctgagcc ctggatga 2118

<210> 39

<211> 968

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 39

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met

705 710 715 720

Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr

725 730 735

Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr

740 745 750

Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser

755 760 765

Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly

770 775 780

Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala

785 790 795 800

Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val

805 810 815

Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp

865 870 875 880

Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala

885 890 895

Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala

900 905 910

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

915 920 925

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

930 935 940

Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln

945 950 955 960

Gly Thr Leu Val Thr Val Ser Ser

965

<210> 40

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 40

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccaa gccgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca acagattcac gcagaagagc 2100

ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga cattcagatg 2160

acacagtcac cgtctacgct ctcagcctca gtaggcgata gggtgactat cacctgccaa 2220

gcctcccaat ctataagttc acacctcaac tggtatcaac agaaacccgg taaagcaccg 2280

aagctgctca tctacaaggc atcaactctt gcctcaggtg tgcctagtcg cttctccggg 2340

agcggctccg gtactgagtt tactttgacg atatcttccc tccaacccga cgacttcgcc 2400

acatactatt gtcagcagg ttatagttgg ggaaatgttg acaatgtgtt tggaggggga 2460

acgaaagtga ctgtgttggg agggggagga agtggcggcg gcggaagcgg aggtggtggc 2520

tccggcgggg gtggaagcga agtgcaattg ctcgaaagtg gtggcggact tgtgcaacct 2580

ggtggaagcc tctcactctc ttgcgcggcg agtggtttta gcttcagtag cggctacgat 2640

atgtgctggg taagacaggc tcctggtaaa ggccttgagt ggattgcgtg tatcgccgcc 2700

gggtctgctg gtataacata cgatgcaaac tgggcgaaag ggcgcttcac aatctccagg 2760

gacaactcaa aaaatacatt gtacctccag atgaatagcc tgagagccga agacaccgca 2820

gtctactatt gcgcaaggtc agcatttagc ttcgattatg caatggatct ttggggccag 2880

gggacgctcg tcaccgtctc atcttga 2907

<210> 41

<211> 705

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 41

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly

705

<210> 42

<211> 2118

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 42

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140

ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200

ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260

gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320

ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380

gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440

aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620

gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860

caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980

ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100

agcctgagcc ctggatga 2118

<210> 43

<211> 706

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 43

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly

705

<210> 44

<211> 2121

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 44

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140

atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200

aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260

ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320

tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380

acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440

gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500

ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560

tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620

ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680

cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740

tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800

ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860

aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920

tggggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980

gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040

aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100

ctgagcctga gccctggatg a 2121

<210> 45

<211> 698

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 45

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

260 265 270

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

275 280 285

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

325 330 335

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

340 345 350

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

355 360 365

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

370 375 380

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

385 390 395 400

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

405 410 415

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

420 425 430

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

435 440 445

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

450 455 460

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695

<210> 46

<211> 2097

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 46

gagatcgtgc tgacccagtc tccttccaca ctgtctgtgt ctcccggcga gagagccacc 60

ttcagctgta gagcctctca gtccatcggc accaacatcc actggtatca gcagaagccc 120

ggcaagcctc ctcggctgct gattaagtac gcctccgagt ccatcagcgg catccctgac 180

agattctccg gctctggctc tggcaccgag tttaccctga ccatctcctc cgtgcagtcc 240

gaggatttcg ccgtgtacta ctgccagcag aacaacaact ggcccaccac ctttggaccc 300

ggcaccaagc tgacagttct tggcggcgga ggatctggcg gaggtggaag cggaggcgga 360

ggaagcggtg gcggcggatc tcaagttcag ttgcagcagt ctggccctgg cctggtcaag 420

ccttctgaga cactgtccat cacctgtacc gtgtccggct tctccctgac caattacggc 480

gtgcactgga tcagacaggc ccctggcaaa ggactggaat ggctgggagt gatttggagc 540

ggcggcaaca ccgactacaa cacccctttc accagccggt tcaccatcac caaggacaac 600

tccaagaacc aggtgtactt caagctgcgg agcgtgcggg ctgatgacac cgccatctac 660

tactgtgctc gggccctgac ctactacgac tacgagtttg cttactgggg ccagggcacc 720

ctggtcacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaca agtgcagttg 780

caagaaagtg gtggtagact ggttcagcct ggtgaaccct tgtcactgac gtgtaaaaca 840

agcggcattg atctgtcctc taacgccatc ggatgggtcc gacaggcccc aggaaaaggt 900

ctggagtgga tcggagttat cttcgggagc ggcaatacat actacgcaag ctgggcaaaa 960

gggcgattta cgatatcacg gagcacctct acagtttatt tgaaaatgaa ctccctccgg 1020

tccgaggata ccgcgatata ttactgtgcc agaggggggt actcctctga tatctggggg 1080

cagggtacac tggttacagt ttcatccgct agcaccaaag gcccctctgt gttccctctg 1140

gccccctcct ccaagagcac ctctggaggc actgctgccc tgggctgcct ggtgaaggac 1200

tacttcccag agcctgtgac tgtgtcctgg aactctggag ccctgacctc tggagtgcac 1260

accttccctg ctgtgctgca gagctctggc ctctacagcc tgtcctctgt ggtcactgtg 1320

ccctcctcca gcctgggcac ccagacctac atctgcaatg tgaaccacaa gccctccaac 1380

accaaggtgg acaagagagt ggagcccaag tcctgtgaca agacccacac ctgccctccc 1440

tgcccagccc cagaggctgc tggaggcccc tctgtgttcc tcttccctcc caagcccaag 1500

gacaccctga tgatctccag gaccccagaa gtcacctgtg tggtggtgga tgtgtcccat 1560

gaagaccag aagtgaagtt caactggtat gtggatggag tggaggtgca caatgccaag 1620

accaagccca gagaagagca gtacaactcc acctaccgag tggtgtctgt gctgactgtg 1680

ctgcaccagg actggctgaa tgggaaggag tacaagtgtg ctgtgtccaa caaggccctg 1740

cctgccccca ttgagaagac catctccaag gccaagggcc agcccagaga gccccaggtc 1800

tacaccctgc ctccctccag agatgagctg accaagaacc aggtgtccct gtcctgtgct 1860

gtgaaaggct tctaccccag tgacattgct gtggagtggg agagcaatgg ccagccagag 1920

aacaactaca agaccacccc tcctgtgctg gactctgatg gctccttctt cctggtctcc 1980

aagctgactg tggacaagag ccgctggcag cagggcaatg tgttctcctg ctctgtcatg 2040

catgaggccc tgcacaacca ctacacccag aagagcctga gcctgagccc tggatga 2097

<210> 47

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 47

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys

465 470 475 480

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

485 490 495

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

500 505 510

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

515 520 525

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

530 535 540

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

545 550 555 560

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

565 570 575

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

580 585 590

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

595 600 605

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp

610 615 620

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

625 630 635 640

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

645 650 655

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

660 665 670

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

675 680 685

Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

690 695 700

<210> 48

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 48

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg ccccctctgt gttcatcttc 1140

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 1200

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 1260

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 1320

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1380

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1440

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1500

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1560

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1620

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1680

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1740

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1800

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1860

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1920

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1980

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 2040

ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 2100

ctgagccctg ga 2112

<210> 49

<211> 698

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 49

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

435 440 445

Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val

450 455 460

Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser

465 470 475 480

Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly

485 490 495

Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn

500 505 510

Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn

515 520 525

Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile

530 535 540

Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr

545 550 555 560

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser

565 570 575

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu

580 585 590

Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly Glu

595 600 605

Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile

610 615 620

His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile Lys

625 630 635 640

Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser

645 650 655

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser Glu

660 665 670

Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr Thr

675 680 685

Phe Gly Pro Gly Thr Lys Leu Thr Val Leu

690 695

<210> 50

<211> 2097

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 50

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctggaggag gaggaggctc tggaggagga ggatcccaag ttcagttgca gcagtctggc 1380

cctggcctgg tcaagccttc tgagacactg tccatcacct gtaccgtgtc cggcttctcc 1440

ctgaccaatt acggcgtgca ctggatcaga caggcccctg gcaaaggact ggaatggctg 1500

ggagtgattt ggagcggcgg caacaccgac tacaacaccc ctttcaccag ccggttcacc 1560

atcaccaagg acaactccaa gaaccaggtg tacttcaagc tgcggagcgt gcgggctgat 1620

gacaccgcca tctactactg tgctcgggcc ctgacctact acgactacga gtttgcttac 1680

tggggccagg gcaccctggt cacagtttct tctggtggtg gtggttcagg cggggggggt 1740

tccggcggag gcggttctgg gggtggaggt tccgagatcg tgctgaccca gtctccttcc 1800

acactgtctg tgtctcccgg cgagagagcc accttcagct gtagagcctc tcagtccatc 1860

ggcaccaaca tccactggta tcagcagaag cccggcaagc ctcctcggct gctgattaag 1920

tacgcctccg agtccatcag cggcatccct gacagattct ccggctctgg ctctggcacc 1980

gagtttaccc tgaccatctc ctccgtgcag tccgaggatt tcgccgtgta ctactgccag 2040

cagaacaaca actggcccac cacctttgga cccggcacca agctgaccgt gctgtga 2097

<210> 51

<211> 699

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 51

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly

435 440 445

Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly

450 455 460

Gly Leu Val Lys Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser

465 470 475 480

Gly Phe Thr Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro

485 490 495

Gly Lys Gly Leu Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala

500 505 510

Ser Tyr Tyr Val Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp

515 520 525

Asp Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu

530 535 540

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe

545 550 555 560

Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly

565 570 575

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu

580 585 590

Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile

595 600 605

Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Phe Val Ser

610 615 620

Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp

625 630 635 640

Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys

645 650 655

Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp

660 665 670

Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser Ser Thr His Val

675 680 685

Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu

690 695

<210> 52

<211> 2100

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 52

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctgcag 1380

gagtcggggg gaggcctggt caagcctgga gggtccctga gcctctcctg tgcagcctct 1440

ggattcacct ttagtagtta ttggatgagc tgggtccgcc aggctccagg gaaggggctg 1500

gagtgggtgg ccaacataaa ccgcgatgga agtgcgagtt actatgtgga ctctgtgaag 1560

ggccgattca ccatctccag agacgacgcc aagaactcac tgtatctgca aatgaacagc 1620

ctgagagctg aggacacggc tgtgtattac tgtgcgagag atcgtggggt gggctacttc 1680

gatctctggg gccgtggcac cctggtcacc gtgtctagcg gtggaggcgg ttcaggcgga 1740

ggtggttccg gcggtggcgg ctcccagtct gccctgactc agcctgcctc cgtgtctggg 1800

tctcctggac agtcgatcac catctcctgc actggaacca gcagtgacgt tggtggttat 1860

aactttgtct cctggtacca acaacaccca ggcaaagccc ccaaactcat gatctatgat 1920

gtcagtgatc ggccctcagg ggtgtctgat cgcttctccg gctccaagtc tggcaacacg 1980

gcctccctga tcatctctgg cctccaggct gacgacgagg ctgattatta ctgcagctca 2040

tatgggagca gcagcactca tgtgattttc ggcggaggga ccaaggtgac cgtcctataa 2100

<210> 53

<211> 705

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 53

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly

705

<210> 54

<211> 2118

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 54

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaaa 1140

ggcccctctg tgttccctct ggccccctcc tccaagagca cctctggagg cactgctgcc 1200

ctgggctgcc tggtgaagga ctacttccca gagcctgtga ctgtgtcctg gaactctgga 1260

gccctgacct ctggagtgca caccttccct gctgtgctgc agagctctgg cctctacagc 1320

ctgtcctctg tggtcactgt gccctcctcc agcctgggca cccagaccta catctgcaat 1380

gtgaaccaca agccctccaa caccaaggtg gacaagagag tggagcccaa gtcctgtgac 1440

aagacccaca cctgccctcc ctgcccagcc ccagaggctg ctggaggccc ctctgtgttc 1500

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 1560

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 1620

gtggaggtgc acaatgccaa gaccaagccc agagaagagc agtacaactc cacctaccga 1680

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 1740

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1800

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1860

caggtgtccc tgtcctgtgc tgtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1920

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1980

ggctccttct tcctggtctc caagctgact gtggacaaga gccgctggca gcagggcaat 2040

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc actacaccca gaagagcctg 2100

agcctgagcc ctggatga 2118

<210> 55

<211> 447

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 55

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

115 120 125

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

130 135 140

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

145 150 155 160

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

165 170 175

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

180 185 190

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

195 200 205

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

210 215 220

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

225 230 235 240

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

245 250 255

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

260 265 270

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

275 280 285

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

290 295 300

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

305 310 315 320

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

325 330 335

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

340 345 350

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

355 360 365

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

370 375 380

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

385 390 395 400

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

405 410 415

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

420 425 430

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

<210> 56

<211> 1344

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 56

gacgtggtca tgacacagag cccttccaca ctgtctgcct ccgtgggcga tagagtgacc 60

atcaactgtc aggcctccga gtccatctcc tcttggctgg cttggtatca gcagaagcct 120

ggcaaggccc ctaagctgct gatctacgag gcttccaagc tggcctctgg cgtgccctct 180

agattttccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct 240

gacgacttcg ccacctacta ctgccaaggc tacttctact tcatctcccg gacctacgtg 300

aactccttcg gcggaggcac caaggtggag atcaagcgta cggtggctgc cccctctgtg 360

ttcatcttcc cacccagtga tgagcagctg aagagtggca cagcctctgt ggtgtgcctg 420

ctcaacaact tctaccccag agaagccaag gtgcagtgga aggtggacaa tgccctgcag 480

agtggcaaca gccaggagag tgtgacagag caggacagca aggacagcac ctacagcctg 540

tcctccaccc tgaccctgtc caaggctgac tatgagaagc acaaggtgta tgcctgtgag 600

gtgacccacc agggcctgag cagccctgtg accaagagct tcaaccgagg agagtgtgga 660

ggagacaaga cccacacctg ccctccctgc ccagccccag aagctgctgg aggcccctct 720

gtgttcctct tccctcccaa gcccaaggac accctgatga tctccaggac cccagaagtc 780

acctgtgtgg tggtggatgt gtcccatgaa gacccagaag tgaagttcaa ctggtatgtg 840

gatggagtgg aagtgcacaa tgccaagacc aagcccagag aagagcagta caacagcacc 900

taccgagtgg tgtctgtgct gactgtgctg caccaggact ggctgaatgg gaaggagtac 960

aagtgtgctg tgtccaacaa ggccctgcct gcccccattg agaagaccat ctccaaggcc 1020

aagggccagc ccagagagcc ccaggtctac accctgcctc cctccagaga tgagctgacc 1080

aagaaccagg tgtccctgtg gtgcctggtg aaaggcttct accccagtga cattgctgtg 1140

gagtgggaga gcaatggcca gccagagaac aactacaaga ccacccctcc tgtgctggac 1200

tctgatggct ccttcttcct gtacagcaag ctgactgtgg acaagagccg ctggcagcag 1260

ggcaatgtgt tctcctgctc tgtcatgcat gaggccctgc acaaccgctt cacccagaag 1320

agcctgagcc tgagccctgg atga 1344

<210> 57

<211> 449

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 57

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

115 120 125

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

130 135 140

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

145 150 155 160

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

165 170 175

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

180 185 190

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

195 200 205

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

210 215 220

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

225 230 235 240

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

245 250 255

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

260 265 270

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

275 280 285

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

290 295 300

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

305 310 315 320

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

325 330 335

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

340 345 350

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

355 360 365

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

370 375 380

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

385 390 395 400

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

405 410 415

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

420 425 430

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

435 440 445

Gly

<210> 58

<211> 1350

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 58

gaggtgcagc tggttgaatc tggcggagga ttggttcagc ctggcggctc tctgagactg 60

tcttgtgccg cttctggctt caccatctcc accaacgcca tgtcctgggt ccgacaggct 120

cctggcaaag gcctggaatg gatcggcgtg atcaccggca gagatattac ctactacgcc 180

tcctgggcca agggcagatt caccatcagc cgggacaact ccaagaacac cctgtacctg 240

cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgctag agatggcggc 300

agcagcgcca tcacctccaa caatatttgg ggccagggca ccctggtcac tgtgtcctct 360

gctagcacca aaggcccctc tgtgttccct ctggccccct cctccaagag cacctctgga 420

ggcactgctg ccctgggctg cctggtgaag gactacttcc cagagcctgt gactgtgtcc 480

tggaactctg gagccctgac ctctggagtg cacaccttcc ctgctgtgct gcagagctct 540

ggcctctaca gcctgtcctc tgtggtcact gtgccctcct ccagcctggg cacccagacc 600

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaagag agtggagccc 660

aagtcctgtg acaagaccca cacctgccct ccctgcccag ccccagaggc tgctggaggc 720

ccctctgtgt tcctcttccc tcccaagccc aaggacaccc tgatgatctc caggacccca 780

gaagtcacct gtgtggtggt ggatgtgtcc catgaagacc cagaagtgaa gttcaactgg 840

tatgtggatg gagtggaggt gcacaatgcc aagaccaagc ccagagaaga gcagtacaac 900

tccacctacc gagtggtgtc tgtgctgact gtgctgcacc aggactggct gaatgggaag 960

gagtacaagt gtgctgtgtc caacaaggcc ctgcctgccc ccattgagaa gaccatctcc 1020

aaggccaagg gccagcccag agagccccag gtctacaccc tgcctccctc cagagatgag 1080

ctgaccaaga accaggtgtc cctgtcctgt gctgtgaaag gcttctaccc cagtgacatt 1140

gctgtggagt gggagagcaa tggccagcca gagaacaact acaagaccac ccctcctgtg 1200

ctggactctg atggctcctt cttcctggtc tccaagctga ctgtggacaa gagccgctgg 1260

cagcagggca atgtgttctc ctgctctgtc atgcatgagg ccctgcacaa ccactacacc 1320

cagaagagcc tgagcctgag ccctggatga 1350

<210> 59

<211> 706

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 59

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly

705

<210> 60

<211> 2121

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 60

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagcggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcccc ctctgtgttc 1140

atcttcccac ccagtgatga gcagctgaag agtggcacag cctctgtggt gtgcctgctc 1200

aacaacttct accccagaga agccaaggtg cagtggaagg tggacaatgc cctgcagagt 1260

ggcaacagcc aggagagtgt gacagagcag gacagcaagg acagcaccta cagcctgtcc 1320

tccaccctga ccctgtccaa ggctgactat gagaagcaca aggtgtatgc ctgtgaggtg 1380

acccaccagg gcctgagcag ccctgtgacc aagagcttca accgaggaga gtgtggagga 1440

gacaagaccc acacctgccc tccctgccca gccccagaag ctgctggagg cccctctgtg 1500

ttcctcttcc ctcccaagcc caaggacacc ctgatgatct ccaggacccc agaagtcacc 1560

tgtgtggtgg tggatgtgtc ccatgaagac ccagaagtga agttcaactg gtatgtggat 1620

ggagtggaag tgcacaatgc caagaccaag cccagagaag agcagtacaa cagcacctac 1680

cgagtggtgt ctgtgctgac tgtgctgcac caggactggc tgaatgggaa ggagtacaag 1740

tgtgctgtgt ccaacaaggc cctgcctgcc cccattgaga agaccatctc caaggccaag 1800

ggccagccca gagagcccca ggtctacacc ctgcctccct ccagagatga gctgaccaag 1860

aaccaggtgt ccctgtggtg cctggtgaaa ggcttctacc ccagtgacat tgctgtggag 1920

tggggagagca atggccagcc agagaacaac tacaagacca cccctcctgt gctggactct 1980

gatggctcct tcttcctgta cagcaagctg actgtggaca agagccgctg gcagcagggc 2040

aatgtgttct cctgctctgt catgcatgag gccctgcaca accgcttcac ccagaagagc 2100

ctgagcctga gccctggatg a 2121

<210> 61

<211> 449

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 61

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

115 120 125

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

130 135 140

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

145 150 155 160

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

165 170 175

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

180 185 190

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

195 200 205

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

210 215 220

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

225 230 235 240

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

245 250 255

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

260 265 270

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

275 280 285

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

290 295 300

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

305 310 315 320

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

325 330 335

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

340 345 350

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

355 360 365

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

370 375 380

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

385 390 395 400

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

405 410 415

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

420 425 430

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

435 440 445

Gly

<210> 62

<211> 1350

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 62

gaggtgcagc tggttgaatc tggcggagga ttggttcagc ctggcggctc tctgagactg 60

tcttgtgccg cttctggctt caccatctcc accaacgcca tgtcctgggt ccgacaggct 120

cctggcaaag gcctggaatg gatcggcgtg atcaccggca gagatattac ctactacgcc 180

tcctgggcca agggcagatt caccatcagc cgggacaact ccaagaacac cctgtacctg 240

cagatgaact ccctgagagc cgaggacacc gccgtgtact actgtgctag agatggcggc 300

agcagcgcca tcacctccaa caatatttgg ggccagggca ccctggtcac tgtgtcctct 360

gctagcacca aaggcccctc tgtgttccct ctggccccct cctccaagag cacctctgga 420

ggcactgctg ccctgggctg cctggtgaag gactacttcc cagagcctgt gactgtgtcc 480

tggaactctg gagccctgac ctctggagtg cacaccttcc ctgctgtgct gcagagctct 540

ggcctctaca gcctgtcctc tgtggtcact gtgccctcct ccagcctggg cacccagacc 600

tacatctgca atgtgaacca caagccctcc aacaccaagg tggacaagag agtggagccc 660

aagtcctgtg acaagaccca cacctgccct ccctgcccag ccccagaggc tgctggaggc 720

ccctctgtgt tcctcttccc tcccaagccc aaggacaccc tgatgatctc caggacccca 780

gaagtcacct gtgtggtggt ggatgtgtcc catgaagacc cagaagtgaa gttcaactgg 840

tatgtggatg gagtggaggt gcacaatgcc aagaccaagc ccagagaaga gcagtacaac 900

tccacctacc gagtggtgtc tgtgctgact gtgctgcacc aggactggct gaatgggaag 960

gagtacaagt gtgctgtgtc caacaaggcc ctgcctgccc ccattgagaa gaccatctcc 1020

aaggccaagg gccagcccag agagccccag gtctacaccc tgcctccctc cagagatgag 1080

ctgaccaaga accaggtgtc cctgtcctgt gctgtgaaag gcttctaccc cagtgacatt 1140

gctgtggagt gggagagcaa tggccagcca gagaacaact acaagaccac ccctcctgtg 1200

ctggactctg atggctcctt cttcctggtc tccaagctga ctgtggacaa gagccgctgg 1260

cagcagggca atgtgttctc ctgctctgtc atgcatgagg ccctgcacaa ccactacacc 1320

cagaagagcc tgagcctgag ccctggatga 1350

<210> 63

<211> 447

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 63

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

115 120 125

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

130 135 140

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

145 150 155 160

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

165 170 175

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

180 185 190

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

195 200 205

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

210 215 220

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

225 230 235 240

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

245 250 255

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

260 265 270

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

275 280 285

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

290 295 300

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

305 310 315 320

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

325 330 335

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

340 345 350

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

355 360 365

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

370 375 380

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

385 390 395 400

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

405 410 415

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

420 425 430

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

<210> 64

<211> 1344

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 64

gacgtggtca tgacacagag cccttccaca ctgtctgcct ccgtgggcga tagagtgacc 60

atcaactgtc aggcctccga gtccatctcc tcttggctgg cttggtatca gcagaagcct 120

ggcaaggccc ctaagctgct gatctacgag gcttccaagc tggcctctgg cgtgccctct 180

agattttccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct 240

gacgacttcg ccacctacta ctgccaaggc tacttctact tcatctcccg gacctacgtg 300

aactccttcg gcggaggcac caaggtggag atcaagcgta cggtggctgc cccctctgtg 360

ttcatcttcc cacccagtga tgagcagctg aagagtggca cagcctctgt ggtgtgcctg 420

ctcaacaact tctaccccag agaagccaag gtgcagtgga aggtggacaa tgccctgcag 480

agtggcaaca gccaggagag tgtgacagag caggacagca aggacagcac ctacagcctg 540

tcctccaccc tgaccctgtc caaggctgac tatgagaagc acaaggtgta tgcctgtgag 600

gtgacccacc agggcctgag cagccctgtg accaagagct tcaaccgagg agagtgtgga 660

ggagacaaga cccacacctg ccctccctgc ccagccccag aagctgctgg aggcccctct 720

gtgttcctct tccctcccaa gcccaaggac accctgatga tctccaggac cccagaagtc 780

acctgtgtgg tggtggatgt gtcccatgaa gacccagaag tgaagttcaa ctggtatgtg 840

gatggagtgg aagtgcacaa tgccaagacc aagcccagag aagagcagta caacagcacc 900

taccgagtgg tgtctgtgct gactgtgctg caccaggact ggctgaatgg gaaggagtac 960

aagtgtgctg tgtccaacaa ggccctgcct gcccccattg agaagaccat ctccaaggcc 1020

aagggccagc ccagagagcc ccaggtctac accctgcctc cctccagaga tgagctgacc 1080

aagaaccagg tgtccctgtg gtgcctggtg aaaggcttct accccagtga cattgctgtg 1140

gagtgggaga gcaatggcca gccagagaac aactacaaga ccacccctcc tgtgctggac 1200

tctgatggct ccttcttcct gtacagcaag ctgactgtgg acaagagccg ctggcagcag 1260

ggcaatgtgt tctcctgctc tgtcatgcat gaggccctgc acaaccgctt cacccagaag 1320

agcctgagcc tgagccctgg atga 1344

<210> 65

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 65

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 66

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 66

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctgga 1326

<210> 67

<211> 445

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 67

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

<210> 68

<211> 1338

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 68

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggatga 1338

<210> 69

<211> 962

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 69

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly

145 150 155 160

Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly

165 170 175

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser

180 185 190

Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys

195 200 205

Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg

210 215 220

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr

705 710 715 720

Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile

725 730 735

Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln

740 745 750

Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn

755 760 765

Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

770 775 780

Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr

785 790 795 800

Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala

805 810 815

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val

835 840 845

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu

850 855 860

Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met

865 870 875 880

Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr

885 890 895

Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg

900 905 910

Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp

930 935 940

Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val

945 950 955 960

Ser Ser

<210> 70

<211> 2889

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 70

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaagtacag ttgcagcaat ccggtcccgg tctcgtcaaa 420

ccgagtgaga cgcttagtat aacgtgtact gtttcaggct ttagccttac gaactatgga 480

gttcactgga ttcggcaggc acccggcaaa ggtttggaat ggctgggtgt tatttggtca 540

ggtggaaata cagactataa cacccccttt acaagtcggt tcacaattac gaaagataat 600

tccaaaaatc aagtttattt caagttgaga tccgtccgcg cggacgacac tgcgatctac 660

tattgtgcga gggcactgac ctactacgat tacgaatttg cgtattgggg gcaagggact 720

cttgtaacag tctcgagcgg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtataccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg cggcggttca ggtggtgggg gatccgacgt tgtgatgacg 2160

cagtctccta gttcagtatc agcgtctgtt ggggatcgag tcacgattac atgccaggcg 2220

agccaaaata ttaggacgta tctgtcttgg tatcaacaaa agcctggtaa ggctccaaaa 2280

ctcctcattt acgccgctgc caacttggct agtggagtac cttcacgctt tagtgggtca 2340

ggttctggaa cagattttac gttgacgatc tccgatttgg aaccagggga cgctgccacg 2400

tattattgcc agtccaccta cctcgggact gactacgttg gtggggcgtt tggcggagga 2460

acaaaactca ctgtacttgg tggtggtggt tcaggcgggg ggggttccgg cggaggcggt 2520

tctggggggtg gaggttccga ggttcagttg gttgaaagtg gggggggact cgttcagcct 2580

ggaggctctt tgcgactttc ttgtaccgct tctgggttca ctataagttc atatcatatg 2640

caatgggtaa gacaggcgcc tggtaaggga cttgaataca taggaacaat aagctctggt 2700

ggtaacgtct attacgcctc atccgcgcgg gggaggttta caatttccag gccttctagc 2760

aaaaacacgg tagatctgca aatgaactct cttcgcgctg aagatacagc agtctactac 2820

tgcgccaggg attcagggta ttctgacccc atgtgggggc agggcacatt ggttaccgtg 2880

tcctcttga 2889

<210> 71

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 71

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

260 265 270

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

275 280 285

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

290 295 300

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

325 330 335

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

340 345 350

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

355 360 365

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

370 375 380

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

385 390 395 400

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

405 410 415

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

420 425 430

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

435 440 445

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

450 455 460

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

610 615 620

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly

690 695 700

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser

705 710 715 720

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

725 730 735

Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys

740 745 750

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala

755 760 765

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

770 775 780

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

785 790 795 800

Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly

805 810 815

Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu

835 840 845

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser

850 855 860

Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp

865 870 875 880

Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala

885 890 895

Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg

900 905 910

Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser

930 935 940

Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 72

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 72

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840

gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900

aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020

acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080

ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380

ggcctgagct cgcccgtcac aaagagcttc aacagggag agtgtggagg cgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100

tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160

ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220

tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280

atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340

ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400

tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460

actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520

ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580

ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640

gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700

ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760

aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820

tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880

gtcaccgtct catcttga 2898

<210> 73

<211> 967

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 73

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val

130 135 140

Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr

145 150 155 160

Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly

165 170 175

Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala

180 185 190

Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn

195 200 205

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn

225 230 235 240

Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

245 250 255

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly

260 265 270

Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly

275 280 285

Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly

290 295 300

Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp

305 310 315 320

Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser

325 330 335

Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr

340 345 350

Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe

355 360 365

Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr

370 375 380

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser

385 390 395 400

Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu

405 410 415

Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His

420 425 430

Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser

435 440 445

Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys

450 455 460

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu

465 470 475 480

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

485 490 495

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

500 505 510

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

515 520 525

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

530 535 540

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

545 550 555 560

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

565 570 575

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

580 585 590

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

595 600 605

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

610 615 620

Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp

625 630 635 640

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

645 650 655

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser

660 665 670

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

675 680 685

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

690 695 700

Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

705 710 715 720

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly

725 730 735

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr

740 745 750

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

755 760 765

Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

770 775 780

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro

785 790 795 800

Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp

805 810 815

Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

835 840 845

Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln

850 855 860

Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile

865 870 875 880

Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

885 890 895

Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser

900 905 910

Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr

915 920 925

Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr

930 935 940

Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly

945 950 955 960

Thr Leu Val Thr Val Ser Ser

965

<210> 74

<211> 2904

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 74

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gcggagggac caaggtggag atcaaaggcg gtggcggtag tgggggaggc 360

ggttctggcg gcggagggtc cggcggtgga ggatcagagg tgcagctggt ggagtctggg 420

ggaggcttgg tccagcctgg ggggtccctg agactctcct gtgcagcctc tggattcacc 480

atcagtacca atgcaatgag ctgggtccgc caggctccag ggaaggggct ggagtggatc 540

ggagtcatta ctggtcgtga tatcacatac tacgcgagct gggcgaaagg cagattcacc 600

atctccagag acaattccaa gaacacgctg tatcttcaaa tgaacagcct gagagccgag 660

gacacggctg tgtattactg tgcgagagac ggtggttctt ctgctattac tagtaacaac 720

atttggggcc agggaaccct ggtcaccgtc tcgagtggcg gtggagggtc cggcggtggt 780

ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840

agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900

caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960

tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020

tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080

ctgacctact acgattacga atttgcgtat tggggggcaag ggactcttgt aacagtctcc 1140

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740

aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800

tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860

gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100

acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160

gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220

attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280

ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340

cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400

ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460

gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520

tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580

ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640

agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700

acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760

tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820

acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880

acattggtta ccgtgtcctc ttga 2904

<210> 75

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 75

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

260 265 270

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

275 280 285

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

290 295 300

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

325 330 335

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

340 345 350

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala

355 360 365

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

370 375 380

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

385 390 395 400

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

405 410 415

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

420 425 430

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

435 440 445

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

450 455 460

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

690 695 700

Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser

705 710 715 720

Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser

725 730 735

Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro

740 745 750

Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser

755 760 765

Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser

770 775 780

Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr

785 790 795 800

Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr

805 810 815

Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly

835 840 845

Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly

850 855 860

Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro

865 870 875 880

Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly

885 890 895

Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg

900 905 910

Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp

930 935 940

Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 76

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 76

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780

acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840

gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900

aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960

tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020

gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080

accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380

gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440

tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800

tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040

catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100

ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160

gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220

ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280

actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340

ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400

agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460

ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcggggggtgg aagcgaagtg 2520

caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580

gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640

ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700

gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760

ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820

tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880

tga 2883

<210> 77

<211> 967

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 77

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val

130 135 140

Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr

145 150 155 160

Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly

165 170 175

Leu Glu Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala

180 185 190

Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn

195 200 205

Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn

225 230 235 240

Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

245 250 255

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly

260 265 270

Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly

275 280 285

Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly

290 295 300

Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp

305 310 315 320

Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser

325 330 335

Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr

340 345 350

Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe

355 360 365

Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr

370 375 380

Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser

385 390 395 400

Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu

405 410 415

Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His

420 425 430

Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser

435 440 445

Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys

450 455 460

Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu

465 470 475 480

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

485 490 495

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

500 505 510

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

515 520 525

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

530 535 540

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

545 550 555 560

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

565 570 575

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

580 585 590

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

595 600 605

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

610 615 620

Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp

625 630 635 640

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

645 650 655

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser

660 665 670

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

675 680 685

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

690 695 700

Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

705 710 715 720

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly

725 730 735

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr

740 745 750

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

755 760 765

Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

770 775 780

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro

785 790 795 800

Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp

805 810 815

Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

835 840 845

Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln

850 855 860

Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile

865 870 875 880

Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

885 890 895

Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser

900 905 910

Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr

915 920 925

Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr

930 935 940

Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly

945 950 955 960

Thr Leu Val Thr Val Ser Ser

965

<210> 78

<211> 2904

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 78

gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60

atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120

ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180

aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240

gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300

aactccttcg gccaaggaac aaagttgact gttcttggtg gcggaggcag tggtggcggg 360

ggcagcggag gtggtggttc agggggtggt gggagcgaag tccaattggt agaaagtggc 420

ggtggtctgg tgcaacctgg tggatctctt cgcctctcat gcgccgctag tggctttact 480

atttcaacta atgcgatgag ctgggttcgc caggcccccg gcaaaggact tgagtgggtc 540

ggcgtcatca ccggcaggga cattacatac tatgcgagtt gggcaaaggg caggttcacg 600

attagccgcg atacttcaaa gaataccgtt taccttcaaa tgaatagctt gagggcggaa 660

gacacagctg tgtattactg cgcgagggat ggaggtagtt ccgccataac ttccaacaac 720

atatggggac aaggcacgct ggttactgtc tcgagtggcg gtggagggtc cggcggtggt 780

ggatcacaag tacagttgca gcaatccggt cccggtctcg tcaaaccgag tgagacgctt 840

agtataacgt gtactgtttc aggctttagc cttacgaact atggagttca ctggattcgg 900

caggcacccg gcaaaggttt ggaatggctg ggtgttattt ggtcaggtgg aaatacagac 960

tataacaccc cctttacaag tcggttcaca attacgaaag ataattccaa aaatcaagtt 1020

tatttcaagt tgagatccgt ccgcgcggac gacactgcga tctactattg tgcgagggca 1080

ctgacctact acgattacga atttgcgtat tggggggcaag ggactcttgt aacagtctcc 1140

agtgctagca ccaagggccc atcggtcttc cccctggcac cctcctccaa gagcacctct 1200

gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 1260

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 1320

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 1380

acctacatct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 1440

cccaaatctt gtgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggg 1500

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 1560

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac 1620

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac 1680

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc 1740

aaggagtaca agtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc 1800

tccaaagcca aagggcagcc ccgagaacca caggtgtata ccctgccccc atcccgggat 1860

gagctgacca agaaccaggt cagcctgtcc tgcgccgtca aaggcttcta tcccagcgac 1920

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc 1980

gtgctggact ccgacggctc cttcttcctc gtgagcaagc tcaccgtgga caagagcagg 2040

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac 2100

acgcagaaga gcctctccct gtctccgggt ggcggcggcg gttcaggtgg tgggggatcc 2160

gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 2220

attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 2280

ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 2340

cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 2400

ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 2460

gcgtttggcg gaggaacaaa actcactgta cttggtggtg gtggttcagg cggggggggt 2520

tccggcggag gcggttctgg gggtggaggt tccgaggttc agttggttga aagtgggggg 2580

ggactcgttc agcctggagg ctctttgcga ctttcttgta ccgcttctgg gttcactata 2640

agttcatatc atatgcaatg ggtaagacag gcgcctggta agggacttga atacatagga 2700

acaataagct ctggtggtaa cgtctattac gcctcatccg cgcgggggag gtttacaatt 2760

tccaggcctt ctagcaaaaa cacggtagat ctgcaaatga actctcttcg cgctgaagat 2820

acagcagtct actactgcgc cagggattca gggtattctg accccatgtg ggggcagggc 2880

acattggtta ccgtgtcctc ttga 2904

<210> 79

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 79

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

260 265 270

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

275 280 285

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

290 295 300

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

325 330 335

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

340 345 350

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala

355 360 365

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

370 375 380

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

385 390 395 400

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

405 410 415

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

420 425 430

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

435 440 445

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

450 455 460

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

690 695 700

Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser

705 710 715 720

Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser

725 730 735

Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro

740 745 750

Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser

755 760 765

Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser

770 775 780

Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr

785 790 795 800

Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr

805 810 815

Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly

835 840 845

Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly

850 855 860

Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro

865 870 875 880

Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly

885 890 895

Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg

900 905 910

Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp

930 935 940

Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 80

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 80

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780

acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840

gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900

aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960

tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020

gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080

accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380

gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440

tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800

tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040

catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100

ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160

gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220

ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280

actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340

ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400

agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460

ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcggggggtgg aagcgaagtg 2520

caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580

gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640

ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700

gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760

ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820

tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880

tga 2883

<210> 81

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 81

Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Gln Gln Leu Leu Glu Ser Gly Gly Arg Leu Ile Lys

130 135 140

Pro Gly Ala Thr Leu Arg Leu Thr Cys Lys Thr Ser Gly Phe Thr Ile

145 150 155 160

Ser Thr Asn Ala Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu

165 170 175

Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser

180 185 190

Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ile Asn Thr Val

195 200 205

Phe Leu Gln Met Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val

260 265 270

Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser

275 280 285

Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly

290 295 300

Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn

305 310 315 320

Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn

325 330 335

Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile

340 345 350

Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr

355 360 365

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly

370 375 380

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly

385 390 395 400

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val

405 410 415

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe

420 425 430

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val

435 440 445

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val

450 455 460

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys

465 470 475 480

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala

485 490 495

Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr

500 505 510

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val

515 520 525

Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val

530 535 540

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser

545 550 555 560

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu

565 570 575

Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala

580 585 590

Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro

595 600 605

Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln

610 615 620

Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala

625 630 635 640

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr

645 650 655

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu

660 665 670

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser

675 680 685

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser

690 695 700

Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val

705 710 715 720

Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg

725 730 735

Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser

740 745 750

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala

755 760 765

Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly

770 775 780

Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp

785 790 795 800

Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val

805 810 815

Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly

820 825 830

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

835 840 845

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

850 855 860

Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser

865 870 875 880

Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr

885 890 895

Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala

900 905 910

Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp

915 920 925

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

930 935 940

Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 82

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 82

gatgtgcaga tgacccagag cccgagcacc ctgagcgcga ccgtgggcca gcgcgtgacc 60

attaactgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120

ggccagccgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180

cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctgcagagc 240

gatgattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300

aacagctttg gcggcggcac ccgcgtggaa attaaaggcg gtggcggtag tgggggaggc 360

ggttctggcg gcggagggtc cggcggtgga ggatcacagc agctgctgga aagcggcggc 420

cgcctgatta aaccgggcgc gaccctgcgc ctgacctgca aaaccagcgg ctttaccatt 480

agcaccaacg cgatgagctg ggtgcgccag ccgccggggca aaggcctgga atggattggc 540

gtgattaccg gccgcgatat tacctattat gcgagctggg cgaaaggccg ctttaccatt 600

agcaaaacca gcattaacac cgtgtttctg cagatgcgca gcctgcgcgc ggaagatacc 660

gcggtgtatt attgcgcgcg cgatggcggc agcagcgcga ttaccagcaa caacatttgg 720

ggccgcggca ccctggtgac cgtgagcagc ggcggtggag ggtccggcgg tggtggatca 780

caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 840

acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 900

cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 960

acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 1020

aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 1080

tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctccagtgct 1140

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1200

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1260

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1320

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1380

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1440

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1500

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1560

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1620

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1680

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1740

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1800

gccaaagggc agccccgaga accacaggtg tataccctgc ccccatcccg ggatgagctg 1860

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1920

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1980

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2040

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2100

aagagcctct ccctgtctcc gggtggcggc ggcggttcag gtggtggggg atccgacgtt 2160

gtgatgacgc agtctcctag ttcagtatca gcgtctgttg gggatcgagt cacgattaca 2220

tgccaggcga gccaaaatat taggacgtat ctgtcttggt atcaacaaaa gcctggtaag 2280

gctccaaaac tcctcattta cgccgctgcc aacttggcta gtggagtacc ttcacgcttt 2340

agtgggtcag gttctggaac agattttacg ttgacgatct ccgatttgga accaggggac 2400

gctgccacgt attattgcca gtccacctac ctcgggactg actacgttgg tggggcgttt 2460

ggcggaggaa caaaactcac tgtacttggt ggtggtggtt caggcggggg gggttccggc 2520

ggaggcggtt ctggggggtgg aggttccgag gttcagttgg ttgaaagtgg ggggggactc 2580

gttcagcctg gaggctcttt gcgactttct tgtaccgctt ctgggttcac tataagttca 2640

tatcatatgc aatgggtaag acaggcgcct ggtaagggac ttgaatacat aggaacaata 2700

agctctggtg gtaacgtcta ttacgcctca tccgcgcggg ggaggtttac aatttccagg 2760

ccttctagca aaaacacggt agatctgcaa atgaactctc ttcgcgctga agatacagca 2820

gtctactact gcgccaggga ttcagggtat tctgacccca tgtgggggca gggcacattg 2880

gttaccgtgt cctcttga 2898

<210> 83

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 83

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

260 265 270

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

275 280 285

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

290 295 300

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

325 330 335

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

340 345 350

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala

355 360 365

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

370 375 380

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

385 390 395 400

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

405 410 415

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

420 425 430

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

435 440 445

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

450 455 460

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

690 695 700

Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser

705 710 715 720

Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser

725 730 735

Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro

740 745 750

Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser

755 760 765

Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser

770 775 780

Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr

785 790 795 800

Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr

805 810 815

Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly

835 840 845

Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly

850 855 860

Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro

865 870 875 880

Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly

885 890 895

Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg

900 905 910

Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp

930 935 940

Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 84

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 84

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780

acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840

gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900

aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960

tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020

gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080

accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380

gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440

tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800

tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040

catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100

ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160

gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220

ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280

actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340

ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400

agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460

ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcggggggtgg aagcgaagtg 2520

caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580

gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640

ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700

gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760

ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820

tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880

tga 2883

<210> 85

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 85

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Ser Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro

65 70 75 80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

115 120 125

Gly Gly Gly Ser Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile

145 150 155 160

Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser

180 185 190

Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val

260 265 270

Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser

275 280 285

Leu Thr Asn Tyr Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly

290 295 300

Leu Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn

305 310 315 320

Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn

325 330 335

Gln Val Tyr Phe Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile

340 345 350

Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr

355 360 365

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly

370 375 380

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly

385 390 395 400

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val

405 410 415

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe

420 425 430

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val

435 440 445

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val

450 455 460

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys

465 470 475 480

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala

485 490 495

Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr

500 505 510

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val

515 520 525

Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val

530 535 540

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser

545 550 555 560

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu

565 570 575

Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala

580 585 590

Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro

595 600 605

Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln

610 615 620

Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala

625 630 635 640

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr

645 650 655

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu

660 665 670

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser

675 680 685

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser

690 695 700

Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val

705 710 715 720

Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg

725 730 735

Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser

740 745 750

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala

755 760 765

Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly

770 775 780

Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp

785 790 795 800

Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val

805 810 815

Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly

820 825 830

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

835 840 845

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

850 855 860

Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser

865 870 875 880

Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr

885 890 895

Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala

900 905 910

Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp

915 920 925

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

930 935 940

Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 86

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 86

gatgtggtga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60

attagctgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120

ggccaggcgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180

cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctggaaccg 240

gaagattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300

aacagctttg gcggcggcac caaagtggaa attaaaggcg gtggcggtag tgggggaggc 360

ggttctggcg gcggagggtc cggcggtgga ggatcacagc agctggtgga aagcggcggc 420

ggcctggtga aaccgggcgg cagcctgcgc ctgagctgcg cggcgagcgg ctttaccatt 480

agcaccaacg cgatgagctg ggtgcgccag gcgccggggca aaggcctgga atgggtgggc 540

gtgattaccg gccgcgatat tacctattat gcgagctggg cgaaaggccg ctttaccatt 600

agcaaaacca gcaaaaacac cgtgtatctg cagatgaaca gcctgcgcgc ggaagatacc 660

gcggtgtatt attgcgcgcg cgatggcggc agcagcgcga ttaccagcaa caacatttgg 720

ggccagggca ccctggtgac cgtgagcagc ggcggtggag ggtccggcgg tggtggatca 780

caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 840

acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 900

cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 960

acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 1020

aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 1080

tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctccagtgct 1140

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1200

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1260

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1320

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1380

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1440

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1500

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1560

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1620

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 1680

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1740

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1800

gccaaagggc agccccgaga accacaggtg tataccctgc ccccatcccg ggatgagctg 1860

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1920

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1980

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2040

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2100

aagagcctct ccctgtctcc gggtggcggc ggcggttcag gtggtggggg atccgacgtt 2160

gtgatgacgc agtctcctag ttcagtatca gcgtctgttg gggatcgagt cacgattaca 2220

tgccaggcga gccaaaatat taggacgtat ctgtcttggt atcaacaaaa gcctggtaag 2280

gctccaaaac tcctcattta cgccgctgcc aacttggcta gtggagtacc ttcacgcttt 2340

agtgggtcag gttctggaac agattttacg ttgacgatct ccgatttgga accaggggac 2400

gctgccacgt attattgcca gtccacctac ctcgggactg actacgttgg tggggcgttt 2460

ggcggaggaa caaaactcac tgtacttggt ggtggtggtt caggcggggg gggttccggc 2520

ggaggcggtt ctggggggtgg aggttccgag gttcagttgg ttgaaagtgg ggggggactc 2580

gttcagcctg gaggctcttt gcgactttct tgtaccgctt ctgggttcac tataagttca 2640

tatcatatgc aatgggtaag acaggcgcct ggtaagggac ttgaatacat aggaacaata 2700

agctctggtg gtaacgtcta ttacgcctca tccgcgcggg ggaggtttac aatttccagg 2760

ccttctagca aaaacacggt agatctgcaa atgaactctc ttcgcgctga agatacagca 2820

gtctactact gcgccaggga ttcagggtat tctgacccca tgtgggggca gggcacattg 2880

gttaccgtgt cctcttga 2898

<210> 87

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 87

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

260 265 270

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

275 280 285

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

290 295 300

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

325 330 335

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

340 345 350

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala

355 360 365

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

370 375 380

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

385 390 395 400

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

405 410 415

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

420 425 430

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

435 440 445

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

450 455 460

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

690 695 700

Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser

705 710 715 720

Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser

725 730 735

Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro

740 745 750

Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser

755 760 765

Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser

770 775 780

Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr

785 790 795 800

Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr

805 810 815

Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly

835 840 845

Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly

850 855 860

Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro

865 870 875 880

Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly

885 890 895

Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg

900 905 910

Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp

930 935 940

Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 88

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 88

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780

acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840

gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900

aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960

tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020

gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080

accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380

gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440

tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800

tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040

catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100

ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160

gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220

ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280

actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340

ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400

agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460

ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcggggggtgg aagcgaagtg 2520

caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580

gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640

ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700

gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760

ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820

tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880

tga 2883

<210> 89

<211> 957

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 89

Asp Pro Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val

65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly

100 105 110

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

115 120 125

Gly Ser Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly

130 135 140

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Ser Ser

145 150 155 160

Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

165 170 175

Val Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala

180 185 190

Lys Gly Arg Phe Thr Ile Ser Arg Ser Lys Asn Thr Val Tyr Leu Gln

195 200 205

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

210 215 220

Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val

225 230 235 240

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu

245 250 255

Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile

260 265 270

Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp

275 280 285

Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp

290 295 300

Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr

305 310 315 320

Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser

325 330 335

Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr

340 345 350

Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr

355 360 365

Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro

370 375 380

Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val

385 390 395 400

Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala

405 410 415

Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly

420 425 430

Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly

435 440 445

Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys

450 455 460

Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys

465 470 475 480

Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu

485 490 495

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu

500 505 510

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys

515 520 525

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys

530 535 540

Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu

545 550 555 560

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala

565 570 575

Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys

580 585 590

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser

595 600 605

Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys

610 615 620

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln

625 630 635 640

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly

645 650 655

Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln

660 665 670

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn

675 680 685

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly

690 695 700

Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser

705 710 715 720

Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser

725 730 735

Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys

740 745 750

Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val

755 760 765

Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr

770 775 780

Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser

785 790 795 800

Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr

805 810 815

Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

820 825 830

Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser

835 840 845

Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr

850 855 860

Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg Gln

865 870 875 880

Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly

885 890 895

Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg

900 905 910

Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp

930 935 940

Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955

<210> 90

<211> 2874

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 90

gatccagttc tgacacaaag tccatccagc ctgtctgcct cagtcggcga cagagtgacc 60

atcagttgcc agagctcaca gtctgtggct aagaacaaca acttggcgtg gttccaacag 120

aaacctggac aggctccgaa attgctgatc tattctgctt ccacgcttgc tgctggtgtt 180

ccttcccgct tttcaggtag tggtagcggg acagacttca ctttgactat aagcagcgtg 240

cagcctgaag attttgcgac ctactattgt tctgctagag acagtggaaa tattcagtcc 300

tttgggggggg gaacgaaggt cgaaataaag ggcggcggag ggtctggtgg gggtggcagt 360

ggtggtggag gaagtggtgg cggtggttcc caacagttgg ttgagtctgg tggcggtctc 420

gttaagcctg gagggtccct tcggcttagt tgtgcggcct ctgggatcga cctgtctagc 480

aacgctatag gatgggtacg gcaagctccg ggcaaaggcc ttgagtgggt cggcgttatt 540

tttgggagcg gtaatacgta ctacgccagc tgggcaaaag gtaggttcac tatcagtcga 600

tcaaagaaca cggtatatct tcagatgaac agtctccggg cggaggacac cgcggtttat 660

tattgcgcaa gggggggata ctcctcagac atatggggcc aaggtacttt ggtgacggtc 720

tcgagcggcg gtggagggtc cggcggtggt ggatcacaag tacagttgca gcaatccggt 780

cccggtctcg tcaaaccgag tgagacgctt agtataacgt gtactgtttc aggctttagc 840

cttacgaact atggagttca ctggattcgg caggcacccg gcaaaggttt ggaatggctg 900

ggtgttattt ggtcaggtgg aaatacagac tataacaccc cctttacaag tcggttcaca 960

attacgaaag ataattccaa aaatcaagtt tatttcaagt tgagatccgt ccgcgcggac 1020

gacactgcga tctactattg tgcgagggca ctgacctact acgattacga atttgcgtat 1080

tggggggcaag ggactcttgt aacagtctcc agtgctagca ccaagggccc atcggtcttc 1140

cccctggcac cctcctccaa gagcacctct gggggcacag cggccctggg ctgcctggtc 1200

aaggactact tccccgaacc ggtgacggtg tcgtggaact caggcgccct gaccagcggc 1260

gtgcacacct tcccggctgt cctacagtcc tcaggactct actccctcag cagcgtggtg 1320

accgtgccct ccagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 1380

agcaacacca aggtggacaa gagagttgag cccaaatctt gtgacaaaac tcacacatgc 1440

ccaccgtgcc cagcacctga agccgcgggg ggaccgtcag tcttcctctt ccccccaaaa 1500

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg 1560

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat 1620

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1680

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcgcggt ctccaacaaa 1740

gccctcccag ccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca 1800

caggtgtata ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgtcc 1860

tgcgccgtca aaggcttcta tcccagcgac atcgccgtgg agtggggagag caatgggcag 1920

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 1980

gtgagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc 2040

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt 2100

ggcggcggcg gttcaggtgg tgggggatcc gacgttgtga tgacgcagtc tcctagttca 2160

gtatcagcgt ctgttgggga tcgagtcacg attacatgcc aggcgagcca aaatattagg 2220

acgtatctgt cttggtatca acaaaagcct ggtaaggctc caaaactcct catttacgcc 2280

gctgccaact tggctagtgg agtaccttca cgctttagtg ggtcaggttc tggaacagat 2340

tttacgttga cgatctccga tttggaacca ggggacgctg ccacgtatta ttgccagtcc 2400

acctacctcg ggactgacta cgttggtggg gcgtttggcg gaggaacaaa actcactgta 2460

cttggtggtg gtggttcagg cggggggggt tccggcggag gcggttctgg gggtggaggt 2520

tccgaggttc agttggttga aagtgggggg ggactcgttc agcctggagg ctctttgcga 2580

ctttcttgta ccgcttctgg gttcactata agttcatatc atatgcaatg ggtaagacag 2640

gcgcctggta agggacttga atacatagga acaataagct ctggtggtaa cgtctattac 2700

gcctcatccg cgcgggggag gtttacaatt tccaggcctt ctagcaaaaa cacggtagat 2760

ctgcaaatga actctcttcg cgctgaagat acagcagtct actactgcgc cagggattca 2820

gggtattctg accccatgtg ggggcagggc acattggtta ccgtgtcctc ttga 2874

<210> 91

<211> 960

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 91

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

260 265 270

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

275 280 285

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

290 295 300

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

325 330 335

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

340 345 350

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu Arg Thr Val Ala Ala

355 360 365

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

370 375 380

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

385 390 395 400

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

405 410 415

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

420 425 430

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

435 440 445

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

450 455 460

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

465 470 475 480

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

485 490 495

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

500 505 510

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

515 520 525

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

530 535 540

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

545 550 555 560

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

565 570 575

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

580 585 590

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

595 600 605

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

610 615 620

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

625 630 635 640

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

645 650 655

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

660 665 670

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe

675 680 685

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

690 695 700

Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser

705 710 715 720

Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser

725 730 735

Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro

740 745 750

Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser

755 760 765

Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser

770 775 780

Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr

785 790 795 800

Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr

805 810 815

Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly

835 840 845

Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly

850 855 860

Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro

865 870 875 880

Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly

885 890 895

Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg

900 905 910

Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala

915 920 925

Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp

930 935 940

Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

945 950 955 960

<210> 92

<211> 2883

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 92

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagtgg cggtggaggg tccggcggtg gtggatcaga aatcgtcctt 780

acacaatctc ctagcacact gagtgtgagc cccggcgaac gcgcgacttt ctcttgcagg 840

gcaagtcaat ccatagggac taatatacat tggtatcaac aaaagccagg taaaccaccc 900

aggcttttga ttaagtatgc aagtgagtct atttccggta tccctgaccg cttctctgga 960

tcaggcagtg gcacagagtt cacactcacc atatctagtg tgcaatcaga ggacttcgcc 1020

gtgtattact gccaacagaa taataactgg ccgactacct tcggacccgg tacaaagctg 1080

accgttttac gtacggtggc tgcaccatct gtcttcatct tcccgccatc tgatgagcag 1140

ttgaaatctg gaactgcctc tgttgtgtgc ctgctgaata acttctatcc cagagaggcc 1200

aaagtacagt ggaaggtgga taacgccctc caatcgggta actcccagga gagtgtcaca 1260

gagcaggaca gcaaggacag cacctacagc ctcagcagca ccctgacgct gagcaaagca 1320

gactacgaga aacacaaagt ctacgcctgc gaagtcaccc atcagggcct gagctcgccc 1380

gtcacaaaga gcttcaacag gggagagtgt ggaggcgaca aaactcacac atgcccaccg 1440

tgcccagcac ctgaagccgc ggggggaccg tcagtcttcc tcttcccccc aaaacccaag 1500

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac 1560

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag 1620

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc 1680

ctgcaccagg actggctgaa tggcaaggag tacaagtgcg cggtctccaa caaagccctc 1740

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg 1800

tacaccctgc ccccaagccg ggatgagctg accaagaacc aggtcagcct gtggtgcctg 1860

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag 1920

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctatagc 1980

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg 2040

catgaggctc tgcacaacag attcacgcag aagagcctct ccctgtctcc gggtggcggt 2100

ggagggtccg gcggtggtgg atccgacatt cagatgacac agtcaccgtc tacgctctca 2160

gcctcagtag gcgatagggt gactatcacc tgccaagcct cccaatctat aagttcacac 2220

ctcaactggt atcaacagaa acccggtaaa gcaccgaagc tgctcatcta caaggcatca 2280

actcttgcct caggtgtgcc tagtcgcttc tccgggagcg gctccggtac tgagtttact 2340

ttgacgatat cttccctcca acccgacgac ttcgccacat actattgtca gcagggttat 2400

agttggggaa atgttgacaa tgtgtttgga gggggaacga aagtgactgt gttgggaggg 2460

ggaggaagtg gcggcggcgg aagcggaggt ggtggctccg gcggggggtgg aagcgaagtg 2520

caattgctcg aaagtggtgg cggacttgtg caacctggtg gaagcctctc actctcttgc 2580

gcggcgagtg gttttagctt cagtagcggc tacgatatgt gctgggtaag acaggctcct 2640

ggtaaaggcc ttgagtggat tgcgtgtatc gccgccgggt ctgctggtat aacatacgat 2700

gcaaactggg cgaaagggcg cttcacaatc tccagggaca actcaaaaaa tacattgtac 2760

ctccagatga atagcctgag agccgaagac accgcagtct actattgcgc aaggtcagca 2820

tttagcttcg attatgcaat ggatctttgg ggccagggga cgctcgtcac cgtctcatct 2880

tga 2883

<210> 93

<211> 840

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 93

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly

130 135 140

Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly

145 150 155 160

Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly

165 170 175

Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr

180 185 190

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser

195 200 205

Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr

210 215 220

Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser

225 230 235 240

Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser

245 250 255

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr

260 265 270

Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro

275 280 285

Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val

290 295 300

His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser

305 310 315 320

Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile

325 330 335

Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val

340 345 350

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

355 360 365

Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

370 375 380

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

385 390 395 400

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

405 410 415

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

420 425 430

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

435 440 445

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala

450 455 460

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

465 470 475 480

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

485 490 495

Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser

500 505 510

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

515 520 525

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val

530 535 540

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

545 550 555 560

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

565 570 575

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly

580 585 590

Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val

595 600 605

Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr

610 615 620

Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu

625 630 635 640

Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser

645 650 655

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu

660 665 670

Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr

675 680 685

Asp Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu

690 695 700

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

705 710 715 720

Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val

725 730 735

Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr

740 745 750

Ile Ser Ser Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly

755 760 765

Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala

770 775 780

Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn

785 790 795 800

Thr Val Asp Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

805 810 815

Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln

820 825 830

Gly Thr Leu Val Thr Val Ser Ser

835 840

<210> 94

<211> 2523

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 94

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actgtctcga gcggcggtgg agggtccggc ggtggtggat cagaggtgca gctggtggag 420

tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtgc agcctctgga 480

ttcaccatca gtaccaatgc aatgagctgg gtccgccagg ctccagggaa ggggctggag 540

tggatcggag tcattactgg tcgtgatatc acatactacg cgagctgggc gaaaggcaga 600

ttcaccatct ccagagacaa ttccaagaac acgctgtatc ttcaaatgaa cagcctgaga 660

gccgaggaca cggctgtgta ttactgtgcg agagacggtg gttcttctgc tattactagt 720

aacaacattt ggggccaggg aaccctggtc accgtgtcct cagctagcac caagggccca 780

tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 840

tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 900

accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 960

agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 1020

cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 1080

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1140

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1200

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1260

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1320

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1380

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1440

cgagaaccac aggtgtatac cctgccccca tcccgggatg agctgaccaa gaaccaggtc 1500

agcctgtcct gcgccgtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1560

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1620

ttcttcctcg tgagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1680

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1740

tctccgggtg gcggcggcgg ttcaggtggt gggggatccg acgttgtgat gacgcagtct 1800

cctagttcag tatcagcgtc tgttggggat cgagtcacga ttacatgcca ggcgagccaa 1860

aatattagga cgtatctgtc ttggtatcaa caaaagcctg gtaaggctcc aaaactcctc 1920

atttacgccg ctgccaactt ggctagtgga gtaccttcac gctttagtgg gtcaggttct 1980

ggaacagatt ttacgttgac gatctccgat ttggaaccag gggacgctgc cacgtattat 2040

tgccagtcca cctacctcgg gactgactac gttggtgggg cgtttggcgg aggaacaaaa 2100

ctcactgtac ttggtggtgg tggttcaggc ggggggggtt ccggcggagg cggttctggg 2160

ggtggaggtt ccgaggttca gttggttgaa agtggggggg gactcgttca gcctggaggc 2220

tctttgcgac tttcttgtac cgcttctggg ttcactataa gttcatatca tatgcaatgg 2280

gtaagacagg cgcctggtaa gggacttgaa tacataggaa caataagctc tggtggtaac 2340

gtctattacg cctcatccgc gcgggggagg tttacaattt ccaggccttc tagcaaaaac 2400

acggtagatc tgcaaatgaa ctctcttcgc gctgaagata cagcagtcta ctactgcgcc 2460

agggattcag ggtattctga ccccatgtgg gggcagggca cattggttac cgtgtcctct 2520

tga 2523

<210> 95

<211> 846

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 95

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly

115 120 125

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser

130 135 140

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys

145 150 155 160

Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys

165 170 175

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala

180 185 190

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

195 200 205

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

210 215 220

Cys Gln Gly Tyr Phe Tyr Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe

225 230 235 240

Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser

245 250 255

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

260 265 270

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

275 280 285

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

290 295 300

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

305 310 315 320

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

325 330 335

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

340 345 350

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

355 360 365

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

370 375 380

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

385 390 395 400

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

405 410 415

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

420 425 430

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

435 440 445

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

450 455 460

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

465 470 475 480

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu

485 490 495

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

500 505 510

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

515 520 525

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

530 535 540

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

545 550 555 560

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln

565 570 575

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

580 585 590

Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser

595 600 605

Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser

610 615 620

Ser His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

625 630 635 640

Leu Ile Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe

645 650 655

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

660 665 670

Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp

675 680 685

Gly Asn Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu

690 695 700

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

705 710 715 720

Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val

725 730 735

Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser

740 745 750

Phe Ser Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys

755 760 765

Gly Leu Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr

770 775 780

Tyr Asp Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn

785 790 795 800

Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp

805 810 815

Thr Ala Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala

820 825 830

Met Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

835 840 845

<210> 96

<211> 2541

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 96

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag cggcggtgga gggtccggcg gtggtggatc agacgtcgtg 420

atgacccagt ctccttccac cctgtctgca tctgtaggag acagagtcac catcaattgc 480

caagccagtg agagcattag cagttggtta gcctggtatc agcagaaacc agggaaagcc 540

cctaagctcc tgatctatga agcatccaaa ctggcatctg gggtcccatc aaggttcagc 600

ggcagtggat ctgggacaga attcactctc accatcagca gcctgcagcc tgatgatttt 660

gcaacttatt actgccaagg ctatttttat tttattagtc gtacttatgt aaattctttc 720

ggcggaggga ccaaggtgga gatcaaacgt acggtggctg caccatctgt cttcatcttc 780

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 840

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 900

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 960

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 1020

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtgg aggcgacaaa 1080

actcacacat gcccaccgtg cccagcacct gaagccgcgg ggggaccgtc agtcttcctc 1140

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg 1200

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg 1260

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg 1320

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcgcg 1380

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag 1440

ccccgagaac cacaggtgta caccctgccc ccaagccggg atgagctgac caagaaccag 1500

gtcagcctgt ggtgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtggggag 1560

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc 1620

tccttcttcc tctatagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1680

ttctcatgct ccgtgatgca tgaggctctg cacaacagat tcacgcagaa gagcctctcc 1740

ctgtctccgg gtggcggtgg agggtccggc ggtggtggat ccgacattca gatgacacag 1800

tcaccgtcta cgctctcagc ctcagtaggc gatagggtga ctatcacctg ccaagcctcc 1860

caatctataa gttcacacct caactggtat caacagaaac ccggtaaagc accgaagctg 1920

ctcatctaca aggcatcaac tcttgcctca ggtgtgccta gtcgcttctc cgggagcggc 1980

tccggtactg agtttacttt gacgatatct tccctccaac ccgacgactt cgccacatac 2040

tattgtcagc agggttatag ttggggaaat gttgacaatg tgtttggagg gggaacgaaa 2100

gtgactgtgt tgggaggggg aggaagtggc ggcggcggaa gcggaggtgg tggctccggc 2160

gggggtggaa gcgaagtgca attgctcgaa agtggtggcg gacttgtgca acctggtgga 2220

agcctctcac tctcttgcgc ggcgagtggt tttagcttca gtagcggcta cgatatgtgc 2280

tgggtaagac aggctcctgg taaaggcctt gagtggattg cgtgtatcgc cgccgggtct 2340

gctggtataa catacgatgc aaactgggcg aaagggcgct tcacaatctc cagggacaac 2400

tcaaaaaata cattgtacct cgatgaat agcctgagag ccgaagacac cgcagtctac 2460

tattgcgcaa ggtcagcatt tagcttcgat tatgcaatgg atctttgggg ccaggggacg 2520

ctcgtcaccg tctcatcttg a 2541

<210> 97

<211> 832

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 97

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg

130 135 140

Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly

145 150 155 160

Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly

165 170 175

Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr

180 185 190

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser

195 200 205

Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile

210 215 220

Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly

225 230 235 240

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe

245 250 255

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu

260 265 270

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp

275 280 285

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu

290 295 300

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser

305 310 315 320

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro

325 330 335

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys

340 345 350

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

355 360 365

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

370 375 380

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

385 390 395 400

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

405 410 415

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

420 425 430

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

435 440 445

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

450 455 460

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

465 470 475 480

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser

485 490 495

Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

500 505 510

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

515 520 525

Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys

530 535 540

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

545 550 555 560

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

565 570 575

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln

580 585 590

Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser Ile Thr Cys

595 600 605

Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Ile Arg

610 615 620

Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly

625 630 635 640

Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Phe Thr Ile Thr

645 650 655

Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe Lys Leu Arg Ser Val Arg

660 665 670

Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr

675 680 685

Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

690 695 700

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

705 710 715 720

Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu

725 730 735

Ser Val Ser Pro Gly Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln

740 745 750

Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro

755 760 765

Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro

770 775 780

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile

785 790 795 800

Ser Ser Val Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn

805 810 815

Asn Asn Trp Pro Thr Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu

820 825 830

<210> 98

<211> 2499

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 98

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420

agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480

attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540

tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600

tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660

gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720

acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780

tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840

ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900

cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960

tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020

gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080

gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140

ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200

ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260

cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320

caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380

cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440

ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500

ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560

tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620

actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680

gccctgcaca accactacac ccagaagagc ctgagcctga gccctggagg aggaggaggc 1740

tctggagggag gaggatccca agttcagttg cagcagtctg gccctggcct ggtcaagcct 1800

tctgagacac tgtccatcac ctgtaccgtg tccggcttct ccctgaccaa ttacggcgtg 1860

cactggatca gacaggcccc tggcaaagga ctggaatggc tgggagtgat ttggagcggc 1920

ggcaacaccg actacaacac ccctttcacc agccggttca ccatcaccaa ggacaactcc 1980

aagaaccagg tgtacttcaa gctgcggagc gtgcgggctg atgacaccgc catctactac 2040

tgtgctcggg ccctgaccta ctacgactac gagtttgctt actggggcca gggcaccctg 2100

gtcacagttt cttctggtgg tggtggttca ggcggggggg gttccggcgg aggcggttct 2160

gggggtggag gttccgagat cgtgctgacc cagtctcctt cccacactgtc tgtgtctccc 2220

ggcgagagag ccaccttcag ctgtagagcc tctcagtcca tcggcaccaa catccactgg 2280

tatcagcaga agcccggcaa gcctcctcgg ctgctgatta agtacgcctc cgagtccatc 2340

agcggcatcc ctgacagatt ctccggctct ggctctggca ccgagtttac cctgaccatc 2400

tcctccgtgc agtccgagga tttcgccgtg tactactgcc agcagaacaa caactggccc 2460

accacctttg gacccggcac caagctgacc gtgctgtga 2499

<210> 99

<211> 836

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 99

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly

115 120 125

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser

130 135 140

Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys

145 150 155 160

Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln

165 170 175

Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr

180 185 190

Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

195 200 205

Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr

210 215 220

Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly

225 230 235 240

Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe

245 250 255

Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val

260 265 270

Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp

275 280 285

Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr

290 295 300

Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr

305 310 315 320

Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val

325 330 335

Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly

340 345 350

Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

355 360 365

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

370 375 380

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

385 390 395 400

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

405 410 415

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

420 425 430

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

435 440 445

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

450 455 460

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

465 470 475 480

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

485 490 495

Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

500 505 510

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

515 520 525

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

530 535 540

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

545 550 555 560

Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser

565 570 575

Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

580 585 590

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly

595 600 605

Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr

610 615 620

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

625 630 635 640

Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val

645 650 655

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr

660 665 670

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

675 680 685

Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr

690 695 700

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

705 710 715 720

Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser

725 730 735

Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser

740 745 750

Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly

755 760 765

Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly

770 775 780

Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu

785 790 795 800

Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser

805 810 815

Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys

820 825 830

Val Thr Val Leu

835

<210> 100

<211> 2511

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 100

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420

ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480

cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540

aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600

ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660

gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720

ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780

agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840

cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900

gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960

ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccaggc 1020

ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080

acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260

cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500

ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620

ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680

tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740

cctggaggag gaggaggctc tggaggagga ggatcccagg tgcagctgca ggagtcgggg 1800

ggaggcctgg tcaagcctgg agggtccctg agcctctcct gtgcagcctc tggattcacc 1860

tttagtagtt attggatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg 1920

gccaacataa accgcgatgg aagtgcgagt tactatgtgg actctgtgaa gggccgattc 1980

accatctcca gagacgacgc caagaactca ctgtatctgc aaatgaacag cctgagagct 2040

gaggacacgg ctgtgtatta ctgtgcgaga gatcgtgggg tgggctactt cgatctctgg 2100

ggccgtggca ccctggtcac cgtgtctagc ggtggaggcg gttcaggcgg aggtggttcc 2160

ggcggtggcg gctcccagtc tgccctgact cagcctgcct ccgtgtctgg gtctcctgga 2220

cagtcgatca ccatctcctg cactggaacc agcagtgacg ttggtggtta taactttgtc 2280

tcctggtacc aacaacaccc aggcaaagcc cccaaactca tgatctatga tgtcagtgat 2340

cggccctcag gggtgtctga tcgcttctcc ggctccaagt ctggcaacac ggcctccctg 2400

atcatctctg gcctccaggc tgacgacgag gctgattatt actgcagctc atatgggagc 2460

agcagcactc atgtgatttt cggcggaggg accaaggtga ccgtcctata a 2511

<210> 101

<211> 583

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 101

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly

130 135 140

Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly

145 150 155 160

Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly

165 170 175

Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr

180 185 190

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser

195 200 205

Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr

210 215 220

Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser

225 230 235 240

Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser

245 250 255

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr

260 265 270

Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro

275 280 285

Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val

290 295 300

His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser

305 310 315 320

Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile

325 330 335

Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val

340 345 350

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

355 360 365

Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

370 375 380

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

385 390 395 400

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

405 410 415

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

420 425 430

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

435 440 445

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala

450 455 460

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

465 470 475 480

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

485 490 495

Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser

500 505 510

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

515 520 525

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val

530 535 540

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

545 550 555 560

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

565 570 575

Ser Leu Ser Leu Ser Pro Gly

580

<210> 102

<211> 1752

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 102

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actgtctcga gcggaggagg aggctctgga ggaggaggca gtgaggtgca gctggtggag 420

agtggaggag gcctggtgca gcctggaggc agcctgcggc tgtcctgtgc tgcctctggc 480

ttcaccatct ccaccaatgc catgtcctgg gtgcgccagg cccctggcaa gggcctggag 540

tggattggag tcatcactgg cagagacatc acctactatg cctcctgggc caaaggccgc 600

ttcaccatct ccagagacaa cagcaagaac accctgtacc tgcagatgag cagcctgcgc 660

agtgaggaca cagctgtgta ctactgtgcc cgagatggag gcagcagtgc catcacctcc 720

aacaacatct ggggccaggg caccctggtc actgtgtcct ctgctagcac caaaggcccc 780

tctgtgttcc ctctggcccc ctcctccaag agcacctctg gaggcactgc tgccctgggc 840

tgcctggtga aggactactt cccagagcct gtgactgtgt cctggaactc tggagccctg 900

acctctggag tgcacacctt ccctgctgtg ctgcagagct ctggcctcta cagcctgtcc 960

tctgtggtca ctgtgccctc ctccagcctg ggcacccaga cctacatctg caatgtgaac 1020

cacaagccct ccaacaccaa ggtggacaag agagtggagc ccaagtcctg tgacaagacc 1080

cacacctgcc ctccctgccc agccccagag gctgctggag gcccctctgt gttcctcttc 1140

cctcccaagc ccaaggacac cctgatgatc tccaggaccc cagaagtcac ctgtgtggtg 1200

gtggatgtgt cccatgaaga cccagaagtg aagttcaact ggtatgtgga tggagtggag 1260

gtgcacaatg ccaagaccaa gcccagagaa gagcagtaca actccaccta ccgagtggtg 1320

tctgtgctga ctgtgctgca ccaggactgg ctgaatggga aggagtacaa gtgtgctgtg 1380

tccaacaagg ccctgcctgc ccccattgag aagaccatct ccaaggccaa gggccagccc 1440

agagagcccc aggtctacac cctgcctccc tccagagatg agctgaccaa gaaccaggtg 1500

tccctgtcct gtgctgtgaa aggcttctac cccagtgaca ttgctgtgga gtggggagagc 1560

aatggccagc cagagaacaa ctacaagacc acccctcctg tgctggactc tgatggctcc 1620

ttcttcctgg tctccaagct gactgtggac aagagccgct ggcagcaggg caatgtgttc 1680

tcctgctctg tcatgcatga ggccctgcac aaccactaca cccagaagag cctgagcctg 1740

agccctggat ga 1752

<210> 103

<211> 584

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 103

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly

115 120 125

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser

130 135 140

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Asn Cys

145 150 155 160

Gln Ala Ser Glu Ser Ile Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys

165 170 175

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala

180 185 190

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

195 200 205

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

210 215 220

Cys Gln Gly Tyr Phe Tyr Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe

225 230 235 240

Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser

245 250 255

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

260 265 270

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

275 280 285

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

290 295 300

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

305 310 315 320

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

325 330 335

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

340 345 350

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

355 360 365

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

370 375 380

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

385 390 395 400

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

405 410 415

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

420 425 430

Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

435 440 445

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

450 455 460

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

465 470 475 480

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu

485 490 495

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

500 505 510

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

515 520 525

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

530 535 540

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

545 550 555 560

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln

565 570 575

Lys Ser Leu Ser Leu Ser Pro Gly

580

<210> 104

<211> 1755

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 104

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag cggaggagga ggctctggag gaggaggcag tgatgtggtg 420

atgacccaga gcccctccac cctgtctgcc tctgtgggag acagagtgac catcaactgc 480

caggccagtg agagcatctc ctcctggctg gcctggtacc agcagaagcc aggcaaggcc 540

cccaagctgc tcatctatga agcctccaag ctggcctctg gagtgccctc ccgcttctct 600

ggctctggct ctggcacaga gttcaccctg accatctcca gcctgcagcc agatgacttt 660

gccacctact actgccaggg ctacttctac ttcatctcca ggacctatgt gaacagcttt 720

ggaggaggca ccaaggtgga gatcaagcgt acggtggctg ccccctctgt gttcatcttc 780

ccacccagtg atgagcagct gaagagtggc acagcctctg tggtgtgcct gctcaacaac 840

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagtggcaac 900

agccaggaga gtgtgacaga gcaggacagc aaggacagca cctacagcct gtcctccacc 960

ctgaccctgt ccaaggctga ctatgagaag cacaaggtgt atgcctgtga ggtgacccac 1020

caggggcctga gcagccctgt gaccaagagc ttcaaccgag gagagtgtgg aggagacaag 1080

acccacacct gccctccctg cccagcccca gaagctgctg gaggcccctc tgtgttcctc 1140

ttccctccca agcccaagga caccctgatg atctccagga ccccagaagt cacctgtgtg 1200

gtggtggatg tgtcccatga agacccagaa gtgaagttca actggtatgt ggatggagtg 1260

gaagtgcaca atgccaagac caagcccaga gaagagcagt acaacagcac ctaccgagtg 1320

gtgtctgtgc tgactgtgct gcaccaggac tggctgaatg ggaaggagta caagtgtgct 1380

gtgtccaaca aggccctgcc tgcccccatt gagaagacca tctccaaggc caagggccag 1440

cccagagagc cccaggtcta caccctgcct ccctccagag atgagctgac caagaaccag 1500

gtgtccctgt ggtgcctggt gaaaggcttc taccccagtg acattgctgt ggagtggggag 1560

agcaatggcc agccagagaa caactacaag accacccctc ctgtgctgga ctctgatggc 1620

tccttcttcc tgtacagcaa gctgactgtg gacaagagcc gctggcagca gggcaatgtg 1680

ttctcctgct ctgtcatgca tgaggccctg cacaaccgct tcacccagaa gagcctgagc 1740

ctgagccctg gatga 1755

<210> 105

<211> 576

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 105

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg

130 135 140

Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly

145 150 155 160

Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly

165 170 175

Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr

180 185 190

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser

195 200 205

Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile

210 215 220

Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly

225 230 235 240

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe

245 250 255

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu

260 265 270

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp

275 280 285

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu

290 295 300

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser

305 310 315 320

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro

325 330 335

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys

340 345 350

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

355 360 365

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

370 375 380

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

385 390 395 400

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

405 410 415

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

420 425 430

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

435 440 445

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

450 455 460

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

465 470 475 480

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser

485 490 495

Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

500 505 510

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

515 520 525

Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys

530 535 540

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

545 550 555 560

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

565 570 575

<210> 106

<211> 1731

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 106

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420

agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480

attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540

tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600

tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660

gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720

acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780

tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840

ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900

cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960

tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020

gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080

gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140

ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200

ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260

cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320

caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380

cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440

ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500

ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560

tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620

actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680

gccctgcaca accactacac ccagaagagc ctgagcctga gccctggatg a 1731

<210> 107

<211> 582

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 107

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly

115 120 125

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser

130 135 140

Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys

145 150 155 160

Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln

165 170 175

Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr

180 185 190

Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

195 200 205

Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr

210 215 220

Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly

225 230 235 240

Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe

245 250 255

Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val

260 265 270

Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp

275 280 285

Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr

290 295 300

Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr

305 310 315 320

Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val

325 330 335

Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly

340 345 350

Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

355 360 365

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

370 375 380

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

385 390 395 400

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

405 410 415

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

420 425 430

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

435 440 445

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

450 455 460

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

465 470 475 480

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

485 490 495

Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

500 505 510

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

515 520 525

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

530 535 540

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

545 550 555 560

Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser

565 570 575

Leu Ser Leu Ser Pro Gly

580

<210> 108

<211> 1749

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 108

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420

ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480

cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540

aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600

ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660

gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720

ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780

agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840

cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900

gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960

ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccagggc 1020

ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080

acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260

cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500

ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620

ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680

tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740

cctggatga 1749

<210> 109

<211> 576

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 109

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

435 440 445

Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val

450 455 460

Gln Ala Gly Asp Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser

465 470 475 480

Phe Asn Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu

485 490 495

Arg Glu Phe Val Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr

500 505 510

Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys

515 520 525

Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala

530 535 540

Val Tyr Tyr Cys Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly

545 550 555 560

Asn Val Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser

565 570 575

<210> 110

<211> 1731

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 110

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctggaggag gaggaggctc tggaggagga ggatccgagg tgcagctgca ggagtctggc 1380

ggcggcctgg tgcaggctgg ggacagcctg agcctgtcct gcctggtgtc tggccgctcc 1440

ttcaactcct acaccatggg ctggttccgc caggcccctg ggaaggagcg ggagtttgtg 1500

gctgccatcc tgtggagtgg ccccaccacc tactatgctg actctgtgaa gggccgcttc 1560

accatctcca gagacaatgc caagaacact gtgtacctgc agatgaacag cctgaagcca 1620

gaggacacag ctgtgtacta ctgtgctgct gccctgggag tgctggtgct ggcccctggc 1680

aatgtgtaca gctactgggg cccaggcacc caggtgactg tgtctagctg a 1731

<210> 111

<211> 582

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 111

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly

435 440 445

Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly

450 455 460

Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Ala Phe Ser

465 470 475 480

Gly Arg Thr Phe Ser Met Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro

485 490 495

Gly Lys Glu Arg Glu Phe Val Ala Ala Asn Arg Gly Arg Gly Leu Ser

500 505 510

Pro Asp Ile Ala Asp Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp

515 520 525

Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu

530 535 540

Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Gln Tyr Gly Ser Ser

545 550 555 560

Trp Pro Gln Arg Ser Ser Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr

565 570 575

Thr Val Thr Val Ser Ser

580

<210> 112

<211> 1749

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 112

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctggtg 1380

cagtctggcg gaggcctggt gcaggctggg ggcagcctga gcctgagctg tgccttctct 1440

ggccgcacct tctccatgta caccatgggc tggttccgcc aggccccagg gaaggagaga 1500

gagtttgtgg ctgccaacag aggcagaggc ctgagcccag acattgctga ctctgtgaat 1560

ggccgcttca ccatctccag agacaatgcc aagaacaccc tgtacctgca gatggacagc 1620

ctgaagccag aggacacagc tgtgtactac tgtgctgctg acctgcagta tggcagcagc 1680

tggcctcaga ggagctctgc tgagtatgac tactggggcc agggcaccac tgtgactgtg 1740

tctagctga 1749

<210> 113

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 113

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 114

<211> 1329

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 114

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctggatga 1329

<210> 115

<211> 582

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 115

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly

115 120 125

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser

130 135 140

Pro Ser Ser Leu Ser Ala Thr Val Gly Gln Arg Val Thr Ile Asn Cys

145 150 155 160

Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln

165 170 175

Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr

180 185 190

Leu Ala Ala Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr

195 200 205

Gln Phe Thr Leu Thr Ile Thr Arg Val Gln Ser Glu Asp Phe Ala Thr

210 215 220

Tyr Tyr Cys Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly

225 230 235 240

Gly Thr Arg Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe

245 250 255

Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val

260 265 270

Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp

275 280 285

Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr

290 295 300

Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr

305 310 315 320

Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val

325 330 335

Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly

340 345 350

Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro

355 360 365

Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

370 375 380

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

385 390 395 400

Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp

405 410 415

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr

420 425 430

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

435 440 445

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu

450 455 460

Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

465 470 475 480

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys

485 490 495

Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

500 505 510

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

515 520 525

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

530 535 540

Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser

545 550 555 560

Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser

565 570 575

Leu Ser Leu Ser Pro Gly

580

<210> 116

<211> 1749

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 116

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag tggcggtgga gggtccggcg gtggtggatc agatcctcaa 420

ttgacccagt cccctagtag cctttctgca accgtgggcc agagggtaac aatcaattgc 480

cagtcaagcc agtccgtagc gaagaataat aatttggcat ggttccaaca aaaaccgggt 540

aaacctccta aactccttat ctactcagct tcaacccttg ccgcgggtgt gcccagccgg 600

ttctcaggct caggttccgg gactcaattt acacttacca tcactcgcgt ccaaagtgag 660

gattttgcaa cctactattg ttctgcacgg gattccggga acatacagtc ctttgggggt 720

ggaactcggg tggagataaa acgtacggtg gctgccccct ctgtgttcat cttcccaccc 780

agtgatgagc agctgaagag tggcacagcc tctgtggtgt gcctgctcaa caacttctac 840

cccagagaag ccaaggtgca gtggaaggtg gacaatgccc tgcagagtgg caacagccag 900

gagagtgtga cagagcagga cagcaaggac agcacctaca gcctgtcctc caccctgacc 960

ctgtccaagg ctgactatga gaagcacaag gtgtatgcct gtgaggtgac ccaccagggc 1020

ctgagcagcc ctgtgaccaa gagcttcaac cgaggagagt gtggaggaga caagacccac 1080

acctgccctc cctgcccagc cccagaagct gctggaggcc cctctgtgtt cctcttccct 1140

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 1200

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaagtg 1260

cacaatgcca agaccaagcc cagagaagag cagtacaaca gcacctaccg agtggtgtct 1320

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 1380

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1440

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1500

ctgtggtgcc tggtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1560

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1620

ttcctgtaca gcaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1680

tgctctgtca tgcatgaggc cctgcacaac cgcttcaccc agaagagcct gagcctgagc 1740

cctggatga 1749

<210> 117

<211> 576

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 117

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly

115 120 125

Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Arg

130 135 140

Leu Val Gln Pro Gly Glu Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly

145 150 155 160

Ile Asp Leu Ser Ser Asn Ala Ile Gly Trp Val Arg Gln Ala Pro Gly

165 170 175

Lys Gly Leu Glu Trp Ile Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr

180 185 190

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser

195 200 205

Thr Val Tyr Leu Lys Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile

210 215 220

Tyr Tyr Cys Ala Arg Gly Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly

225 230 235 240

Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe

245 250 255

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu

260 265 270

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp

275 280 285

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu

290 295 300

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser

305 310 315 320

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro

325 330 335

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys

340 345 350

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro

355 360 365

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

370 375 380

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

385 390 395 400

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

405 410 415

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

420 425 430

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

435 440 445

Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

450 455 460

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

465 470 475 480

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Ser

485 490 495

Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

500 505 510

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

515 520 525

Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys

530 535 540

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

545 550 555 560

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

565 570 575

<210> 118

<211> 1731

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 118

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actgtctcga gcggcggtgg agggtccggc ggtggtggat cacaagtgca gttgcaagaa 420

agtggtggta gactggttca gcctggtgaa cccttgtcac tgacgtgtaa aacaagcggc 480

attgatctgt cctctaacgc catcggatgg gtccgacagg ccccaggaaa aggtctggag 540

tggatcggag ttatcttcgg gagcggcaat acatactacg caagctgggc aaaagggcga 600

tttacgatat cacggagcac ctctacagtt tatttgaaaa tgaactccct ccggtccgag 660

gataccgcga tatattactg tgccagaggg gggtactcct ctgatatctg ggggcagggt 720

acactggtta cagtttcatc cgctagcacc aaaggcccct ctgtgttccc tctggccccc 780

tcctccaaga gcacctctgg aggcactgct gccctgggct gcctggtgaa ggactacttc 840

ccagagcctg tgactgtgtc ctggaactct ggagccctga cctctggagt gcacaccttc 900

cctgctgtgc tgcagagctc tggcctctac agcctgtcct ctgtggtcac tgtgccctcc 960

tccagcctgg gcacccagac ctacatctgc aatgtgaacc acaagccctc caacaccaag 1020

gtggacaaga gagtggagcc caagtcctgt gacaagaccc acacctgccc tccctgccca 1080

gccccagagg ctgctggagg cccctctgtg ttcctcttcc ctcccaagcc caaggacacc 1140

ctgatgatct ccaggacccc agaagtcacc tgtgtggtgg tggatgtgtc ccatgaagac 1200

ccagaagtga agttcaactg gtatgtggat ggagtggagg tgcacaatgc caagaccaag 1260

cccagagaag agcagtacaa ctccacctac cgagtggtgt ctgtgctgac tgtgctgcac 1320

caggactggc tgaatgggaa ggagtacaag tgtgctgtgt ccaacaaggc cctgcctgcc 1380

cccattgaga agaccatctc caaggccaag ggccagccca gagagcccca ggtctacacc 1440

ctgcctccct ccagagatga gctgaccaag aaccaggtgt ccctgtcctg tgctgtgaaa 1500

ggcttctacc ccagtgacat tgctgtggag tgggagagca atggccagcc agagaacaac 1560

tacaagacca cccctcctgt gctggactct gatggctcct tcttcctggt ctccaagctg 1620

actgtggaca agagccgctg gcagcagggc aatgtgttct cctgctctgt catgcatgag 1680

gccctgcaca accactacac ccagaagagc ctgagcctga gccctggatg a 1731

<210> 119

<211> 445

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 119

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

<210> 120

<211> 1338

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 120

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggatga 1338

<210> 121

<211> 442

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 121

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440

<210> 122

<211> 1329

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 122

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctggatga 1329

<210> 123

<211> 582

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 123

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly

435 440 445

Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Gly

450 455 460

Gly Leu Val Gln Ala Gly Gly Ser Leu Ser Leu Ser Cys Ala Phe Ser

465 470 475 480

Gly Arg Thr Phe Ser Met Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro

485 490 495

Gly Lys Glu Arg Glu Phe Val Ala Ala Asn Arg Gly Arg Gly Leu Ser

500 505 510

Pro Asp Ile Ala Asp Ser Val Asn Gly Arg Phe Thr Ile Ser Arg Asp

515 520 525

Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys Pro Glu

530 535 540

Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Leu Gln Tyr Gly Ser Ser

545 550 555 560

Trp Pro Gln Arg Ser Ser Ala Glu Tyr Asp Tyr Trp Gly Gln Gly Thr

565 570 575

Thr Val Thr Val Ser Ser

580

<210> 124

<211> 1749

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 124

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggaggagg aggaggctct ggaggaggag gatcccaggt gcagctggtg 1380

cagtctggcg gaggcctggt gcaggctggg ggcagcctga gcctgagctg tgccttctct 1440

ggccgcacct tctccatgta caccatgggc tggttccgcc aggccccagg gaaggagaga 1500

gagtttgtgg ctgccaacag aggcagaggc ctgagcccag acattgctga ctctgtgaat 1560

ggccgcttca ccatctccag agacaatgcc aagaacaccc tgtacctgca gatggacagc 1620

ctgaagccag aggacacagc tgtgtactac tgtgctgctg acctgcagta tggcagcagc 1680

tggcctcaga ggagctctgc tgagtatgac tactggggcc agggcaccac tgtgactgtg 1740

tctagctga 1749

<210> 125

<211> 576

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 125

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser

115 120 125

Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln

180 185 190

Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro

210 215 220

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

225 230 235 240

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

245 250 255

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

260 265 270

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

275 280 285

Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

290 295 300

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

305 310 315 320

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

325 330 335

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp

340 345 350

Glu Leu Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe

355 360 365

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

370 375 380

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

385 390 395 400

Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

405 410 415

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

420 425 430

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly

435 440 445

Gly Gly Gly Ser Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val

450 455 460

Gln Ala Gly Asp Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser

465 470 475 480

Phe Asn Ser Tyr Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu

485 490 495

Arg Glu Phe Val Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr

500 505 510

Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys

515 520 525

Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala

530 535 540

Val Tyr Tyr Cys Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly

545 550 555 560

Asn Val Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser

565 570 575

<210> 126

<211> 1731

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 126

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa aggcccctct 360

gtgttccctc tggccccctc ctccaagagc acctctggag gcactgctgc cctgggctgc 420

ctggtgaagg actacttccc agagcctgtg actgtgtcct ggaactctgg agccctgacc 480

tctggagtgc acaccttccc tgctgtgctg cagagctctg gcctctacag cctgtcctct 540

gtggtcactg tgccctcctc cagcctgggc acccagacct acatctgcaa tgtgaaccac 600

aagccctcca acaccaaggt ggacaagaga gtggagccca agtcctgtga caagacccac 660

acctgccctc cctgcccagc cccagaggct gctggaggcc cctctgtgtt cctcttccct 720

cccaagccca aggacaccct gatgatctcc aggaccccag aagtcacctg tgtggtggtg 780

gatgtgtccc atgaagaccc agaagtgaag ttcaactggt atgtggatgg agtggaggtg 840

cacaatgcca agaccaagcc cagagaagag cagtacaact ccacctaccg agtggtgtct 900

gtgctgactg tgctgcacca ggactggctg aatgggaagg agtacaagtg tgctgtgtcc 960

aacaaggccc tgcctgcccc cattgagaag accatctcca aggccaaggg ccagcccaga 1020

gagccccagg tctacaccct gcctccctcc agagatgagc tgaccaagaa ccaggtgtcc 1080

ctgtcctgtg ctgtgaaagg cttctacccc agtgacattg ctgtggagtg ggagagcaat 1140

ggccagccag agaacaacta caagaccacc cctcctgtgc tggactctga tggctccttc 1200

ttcctggtct ccaagctgac tgtggacaag agccgctggc agcagggcaa tgtgttctcc 1260

tgctctgtca tgcatgaggc cctgcacaac cactacaccc agaagagcct gagcctgagc 1320

cctggaggag gaggaggctc tggaggagga ggatccgagg tgcagctgca ggagtctggc 1380

ggcggcctgg tgcaggctgg ggacagcctg agcctgtcct gcctggtgtc tggccgctcc 1440

ttcaactcct acaccatggg ctggttccgc caggcccctg ggaaggagcg ggagtttgtg 1500

gctgccatcc tgtggagtgg ccccaccacc tactatgctg actctgtgaa gggccgcttc 1560

accatctcca gagacaatgc caagaacact gtgtacctgc agatgaacag cctgaagcca 1620

gaggacacag ctgtgtacta ctgtgctgct gccctgggag tgctggtgct ggcccctggc 1680

aatgtgtaca gctactgggg cccaggcacc caggtgactg tgtctagctg a 1731

<210> 127

<211> 445

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 127

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys Arg Thr

100 105 110

Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu

115 120 125

Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro

130 135 140

Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly

145 150 155 160

Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr

165 170 175

Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His

180 185 190

Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val

195 200 205

Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr

210 215 220

Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe

225 230 235 240

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro

245 250 255

Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val

260 265 270

Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr

275 280 285

Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val

290 295 300

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys

305 310 315 320

Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser

325 330 335

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro

340 345 350

Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val

355 360 365

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly

370 375 380

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp

385 390 395 400

Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp

405 410 415

Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His

420 425 430

Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

<210> 128

<211> 1338

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 128

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa cgtacggtgg ctgccccctc tgtgttcatc 360

ttcccaccca gtgatgagca gctgaagagt ggcacagcct ctgtggtgtg cctgctcaac 420

aacttctacc ccagagaagc caaggtgcag tggaaggtgg acaatgccct gcagagtggc 480

aacagccagg agagtgtgac agagcaggac agcaaggaca gcacctacag cctgtcctcc 540

accctgaccc tgtccaaggc tgactatgag aagcacaagg tgtatgcctg tgaggtgacc 600

caccagggcc tgagcagccc tgtgaccaag agcttcaacc gaggaggtg tggagaggagac 660

aagacccaca cctgccctcc ctgcccagcc ccagaagctg ctggaggccc ctctgtgttc 720

ctcttccctc ccaagcccaa ggacaccctg atgatctcca ggaccccaga agtcacctgt 780

gtggtggtgg atgtgtccca tgaagaccca gaagtgaagt tcaactggta tgtggatgga 840

gtggaagtgc acaatgccaa gaccaagccc agagaagagc agtacaacag cacctaccga 900

gtggtgtctg tgctgactgt gctgcaccag gactggctga atgggaagga gtacaagtgt 960

gctgtgtcca acaaggccct gcctgccccc attgagaaga ccatctccaa ggccaagggc 1020

cagcccagag agccccaggt ctacaccctg cctccctcca gagatgagct gaccaagaac 1080

caggtgtccc tgtggtgcct ggtgaaaggc ttctacccca gtgacattgc tgtggagtgg 1140

gagagcaatg gccagccaga gaacaactac aagaccaccc ctcctgtgct ggactctgat 1200

ggctccttct tcctgtacag caagctgact gtggacaaga gccgctggca gcagggcaat 1260

gtgttctcct gctctgtcat gcatgaggcc ctgcacaacc gcttcaccca gaagagcctg 1320

agcctgagcc ctggatga 1338

<210> 129

<211> 963

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 129

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile

20 25 30

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr

35 40 45

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu

65 70 75 80

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr

85 90 95

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val

130 135 140

Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met

145 150 155 160

His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala

165 170 175

Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly

180 185 190

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln

195 200 205

Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg

210 215 220

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly

225 230 235 240

Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

245 250 255

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

260 265 270

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr

275 280 285

Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

290 295 300

Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala

305 310 315 320

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

325 330 335

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

340 345 350

Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly

355 360 365

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser

370 375 380

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala

385 390 395 400

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val

405 410 415

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala

420 425 430

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val

435 440 445

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His

450 455 460

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met

705 710 715 720

Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr

725 730 735

Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr

740 745 750

Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala

755 760 765

Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly

770 775 780

Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala

785 790 795 800

Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly

805 810 815

Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

820 825 830

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu

835 840 845

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser

850 855 860

Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His

865 870 875 880

Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly

885 890 895

Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly

900 905 910

Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln

915 920 925

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

930 935 940

Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr

945 950 955 960

Val Ser Ser

<210> 130

<211> 2892

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 130

cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60

atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120

agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240

gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300

accaagctga ccgtgctggg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtgcagctg cagcagcccg gcgccgagct ggtgaagccc 420

ggcgccagcg tgaagatgag ctgcaaggcc agcggctaca ccttcaccag ctacaacatg 480

cactgggtga agcagacccc cggccggggc ctggagtgga tcggcgccat ctaccccggc 540

aacggcgaca ccagctacaa ccagaagttc aagggcaagg ccaccctgac cgccgacaag 600

agcagcagca ccgcctacat gcagctgagc agcctgacca gcgaggacag cgccgtgtac 660

tactgcgccc ggagcaccta ctacggcggc gactggtact tcaacgtgtg gggcgccggc 720

accaccgtga ccgtctcgag cggcggtgga gggtccggcg gtggtggatc agaggtgcag 780

ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840

gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900

gggctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960

aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020

agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080

attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtatacc ctgcccccat cccgggatga gctgaccaag 1860

aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccgggtgg cggcggcggt tcaggtggtg ggggatccga cgttgtgatg 2160

acgcagtctc ctagttcagt atcagcgtct gttggggatc gagtcacgat tacatgccag 2220

gcgagccaaa atattaggac gtatctgtct tggtatcaac aaaagcctgg taaggctcca 2280

aaactcctca tttacgccgc tgccaacttg gctagtggag taccttcacg ctttagtggg 2340

tcaggttctg gaacagattt tacgttgacg atctccgatt tggaaccagg ggacgctgcc 2400

acgtattatt gccagtccac ctacctcggg actgactacg ttggtggggc gtttggcgga 2460

ggaacaaaac tcactgtact tggtggtggt ggttcaggcg gggggggttc cggcggaggc 2520

ggttctgggg gtggaggttc cgaggttcag ttggttgaaa gtgggggggg actcgttcag 2580

cctggaggct ctttgcgact ttcttgtacc gcttctgggt tcactataag ttcatatcat 2640

atgcaatggg taagacaggc gcctggtaag ggacttgaat acataggaac aataagctct 2700

ggtggtaacg tctattacgc ctcatccgcg cgggggaggt ttacaatttc caggccttct 2760

agcaaaaaca cggtagatct gcaaatgaac tctcttcgcg ctgaagatac agcagtctac 2820

tactgcgcca gggattcagg gtattctgac cccatgtggg ggcagggcac attggttacc 2880

gtgtcctcttga 2892

<210> 131

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 131

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

260 265 270

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

275 280 285

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

290 295 300

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

325 330 335

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

340 345 350

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

355 360 365

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

370 375 380

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

385 390 395 400

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

405 410 415

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

420 425 430

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

435 440 445

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

450 455 460

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

610 615 620

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly

690 695 700

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser

705 710 715 720

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

725 730 735

Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys

740 745 750

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala

755 760 765

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

770 775 780

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

785 790 795 800

Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly

805 810 815

Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu

835 840 845

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser

850 855 860

Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp

865 870 875 880

Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala

885 890 895

Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg

900 905 910

Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser

930 935 940

Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 132

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 132

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840

gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900

aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020

acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080

ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380

ggcctgagct cgcccgtcac aaagagcttc aacagggag agtgtggagg cgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100

tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160

ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220

tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280

atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340

ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400

tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460

actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520

ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580

ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640

gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700

ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760

aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820

tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880

gtcaccgtct catcttga 2898

<210> 133

<211> 963

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 133

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile

20 25 30

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr

35 40 45

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu

65 70 75 80

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr

85 90 95

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val

130 135 140

Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Asn Met

145 150 155 160

His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile Gly Ala

165 170 175

Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys Gly

180 185 190

Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gln

195 200 205

Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala Arg

210 215 220

Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly Ala Gly

225 230 235 240

Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

245 250 255

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

260 265 270

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr

275 280 285

Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp

290 295 300

Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala

305 310 315 320

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

325 330 335

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

340 345 350

Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly

355 360 365

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser

370 375 380

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala

385 390 395 400

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val

405 410 415

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala

420 425 430

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val

435 440 445

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His

450 455 460

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met

705 710 715 720

Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr

725 730 735

Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr

740 745 750

Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala

755 760 765

Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly

770 775 780

Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala

785 790 795 800

Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly

805 810 815

Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser

820 825 830

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu

835 840 845

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser

850 855 860

Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His

865 870 875 880

Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly

885 890 895

Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly

900 905 910

Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln

915 920 925

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

930 935 940

Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr

945 950 955 960

Val Ser Ser

<210> 134

<211> 2892

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 134

cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60

atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120

agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240

gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300

accaagctga ccgtgctggg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtgcagctg cagcagcccg gcgccgagct ggtgaagccc 420

ggcgccagcg tgaagatgag ctgcaaggcc agcggctaca ccttcaccag ctacaacatg 480

cactgggtga agcagacccc cggccggggc ctggagtgga tcggcgccat ctaccccggc 540

aacggcgaca ccagctacaa ccagaagttc aagggcaagg ccaccctgac cgccgacaag 600

agcagcagca ccgcctacat gcagctgagc agcctgacca gcgaggacag cgccgtgtac 660

tactgcgccc ggagcaccta ctacggcggc gactggtact tcaacgtgtg gggcgccggc 720

accaccgtga ccgtctcgag cggcggtgga gggtccggcg gtggtggatc agaggtgcag 780

ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840

gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900

tgtctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960

aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020

agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080

attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtatacc ctgcccccat cccgggatga gctgaccaag 1860

aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccgggtgg cggcggcggt tcaggtggtg ggggatccga cgttgtgatg 2160

acgcagtctc ctagttcagt atcagcgtct gttggggatc gagtcacgat tacatgccag 2220

gcgagccaaa atattaggac gtatctgtct tggtatcaac aaaagcctgg taaggctcca 2280

aaactcctca tttacgccgc tgccaacttg gctagtggag taccttcacg ctttagtggg 2340

tcaggttctg gaacagattt tacgttgacg atctccgatt tggaaccagg ggacgctgcc 2400

acgtattatt gccagtccac ctacctcggg actgactacg ttggtggggc gtttggcgga 2460

ggaacaaaac tcactgtact tggtggtggt ggttcaggcg gggggggttc cggcggaggc 2520

ggttctgggg gtggaggttc cgaggttcag ttggttgaaa gtgggggggg actcgttcag 2580

cctggaggct ctttgcgact ttcttgtacc gcttctgggt tcactataag ttcatatcat 2640

atgcaatggg taagacaggc gcctggtaag ggacttgaat acataggaac aataagctct 2700

ggtggtaacg tctattacgc ctcatccgcg cgggggaggt ttacaatttc caggccttct 2760

agcaaaaaca cggtagatct gcaaatgaac tctcttcgcg ctgaagatac agcagtctac 2820

tactgcgcca gggattcagg gtattctgac cccatgtggg ggcagggcac attggttacc 2880

gtgtcctcttga 2892

<210> 135

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 135

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

260 265 270

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

275 280 285

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

290 295 300

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

325 330 335

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

340 345 350

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

355 360 365

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

370 375 380

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

385 390 395 400

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

405 410 415

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

420 425 430

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

435 440 445

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

450 455 460

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

610 615 620

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly

690 695 700

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser

705 710 715 720

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

725 730 735

Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys

740 745 750

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala

755 760 765

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

770 775 780

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

785 790 795 800

Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly

805 810 815

Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu

835 840 845

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser

850 855 860

Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp

865 870 875 880

Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala

885 890 895

Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg

900 905 910

Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser

930 935 940

Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 136

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 136

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840

gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900

aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020

acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080

tgtgggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380

ggcctgagct cgcccgtcac aaagagcttc aacagggag agtgtggagg cgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100

tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160

ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220

tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280

atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340

ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400

tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460

actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520

ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580

ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640

gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700

ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760

aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820

tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880

gtcaccgtct catcttga 2898

<210> 137

<211> 706

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 137

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp

145 150 155 160

Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp

165 170 175

Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu

180 185 190

Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser

195 200 205

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys

210 215 220

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr

225 230 235 240

Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Lys

705

<210> 138

<211> 2121

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 138

Gly Ala Cys Ala Thr Cys Cys Ala Gly Ala Thr Gly Ala Cys Cys Cys

1 5 10 15

Ala Gly Thr Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Cys Thr

20 25 30

Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Gly Thr Ala Gly Gly Ala

35 40 45

Gly Ala Cys Ala Gly Ala Gly Thr Cys Ala Cys Cys Ala Thr Cys Ala

50 55 60

Cys Thr Thr Gly Cys Cys Ala Gly Gly Cys Gly Ala Gly Thr Cys Ala

65 70 75 80

Gly Gly Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Cys Thr Ala Thr

85 90 95

Thr Thr Ala Ala Ala Thr Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys

100 105 110

Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Gly Ala Ala Ala Gly Cys

115 120 125

Cys Cys Cys Thr Ala Ala Ala Cys Thr Cys Cys Thr Gly Ala Thr Cys

130 135 140

Thr Ala Cys Gly Ala Thr Gly Cys Ala Thr Cys Cys Ala Ala Thr Thr

145 150 155 160

Thr Gly Gly Ala Ala Ala Cys Ala Gly Gly Gly Gly Thr Cys Cys Cys

165 170 175

Ala Thr Cys Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Ala

180 185 190

Ala Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Ala Gly

195 200 205

Ala Thr Thr Thr Thr Ala Cys Thr Thr Thr Cys Ala Cys Cys Ala Thr

210 215 220

Cys Ala Gly Cys Ala Gly Cys Cys Thr Gly Cys Ala Gly Cys Cys Thr

225 230 235 240

Gly Ala Ala Gly Ala Thr Ala Thr Thr Gly Cys Ala Ala Cys Ala Thr

245 250 255

Ala Thr Thr Thr Cys Thr Gly Thr Cys Ala Ala Cys Ala Cys Thr Thr

260 265 270

Thr Gly Ala Thr Cys Ala Thr Cys Thr Cys Cys Cys Gly Cys Thr Cys

275 280 285

Gly Cys Thr Thr Thr Cys Gly Gly Cys Thr Gly Thr Gly Gly Gly Ala

290 295 300

Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Ala Ala Thr Thr Ala Ala

305 310 315 320

Ala Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Thr Ala Gly Thr

325 330 335

Gly Gly Gly Gly Gly Ala Gly Gly Cys Gly Gly Thr Thr Cys Thr Gly

340 345 350

Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly Gly Thr Cys Cys Gly Gly

355 360 365

Cys Gly Gly Thr Gly Gly Ala Gly Gly Ala Thr Cys Ala Cys Ala Gly

370 375 380

Gly Thr Gly Cys Ala Gly Cys Thr Gly Cys Ala Gly Gly Ala Gly Thr

385 390 395 400

Cys Gly Gly Gly Cys Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly Thr

405 410 415

Gly Ala Ala Gly Cys Cys Thr Thr Cys Gly Gly Ala Gly Ala Cys Cys

420 425 430

Cys Thr Gly Thr Cys Cys Cys Thr Cys Ala Cys Cys Thr Gly Cys Ala

435 440 445

Cys Thr Gly Thr Cys Thr Cys Thr Gly Gly Thr Gly Gly Cys Thr Cys

450 455 460

Cys Gly Thr Cys Ala Gly Cys Ala Gly Thr Gly Gly Thr Gly Ala Thr

465 470 475 480

Thr Ala Cys Thr Ala Cys Thr Gly Gly Ala Cys Cys Thr Gly Gly Ala

485 490 495

Thr Cys Cys Gly Gly Cys Ala Gly Thr Cys Cys Cys Cys Ala Gly Gly

500 505 510

Gly Ala Ala Gly Thr Gly Cys Cys Thr Gly Gly Ala Gly Thr Gly Gly

515 520 525

Ala Thr Thr Gly Gly Ala Cys Ala Cys Ala Thr Cys Thr Ala Thr Thr

530 535 540

Ala Cys Ala Gly Thr Gly Gly Gly Ala Ala Cys Ala Cys Cys Ala Ala

545 550 555 560

Thr Thr Ala Thr Ala Ala Cys Cys Cys Cys Thr Cys Cys Cys Thr Cys

565 570 575

Ala Ala Gly Ala Gly Cys Cys Gly Ala Cys Thr Cys Ala Cys Cys Ala

580 585 590

Thr Ala Thr Cys Ala Ala Thr Thr Gly Ala Cys Ala Cys Gly Thr Cys

595 600 605

Cys Ala Ala Gly Ala Cys Thr Cys Ala Gly Thr Thr Cys Thr Cys Cys

610 615 620

Cys Thr Gly Ala Ala Gly Cys Thr Gly Ala Gly Thr Thr Cys Thr Gly

625 630 635 640

Thr Gly Ala Cys Cys Gly Cys Thr Gly Cys Gly Gly Ala Cys Ala Cys

645 650 655

Gly Gly Cys Cys Ala Thr Thr Thr Ala Thr Thr Ala Cys Thr Gly Thr

660 665 670

Gly Thr Gly Cys Gly Ala Gly Ala Thr Cys Gly Ala Gly Thr Gly Ala

675 680 685

Cys Thr Gly Gly Thr Gly Cys Thr Thr Thr Thr Gly Ala Thr Ala Thr

690 695 700

Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala Gly Gly Gly Ala Cys Ala

705 710 715 720

Ala Thr Gly Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Gly Ala

725 730 735

Cys Ala Gly Gly Cys Gly Gly Thr Gly Gly Ala Gly Gly Gly Thr Cys

740 745 750

Cys Gly Gly Cys Gly Gly Thr Gly Gly Thr Gly Gly Ala Thr Cys Ala

755 760 765

Gly Ala Gly Gly Thr Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Gly

770 775 780

Ala Gly Thr Cys Thr Gly Gly Gly Gly Gly Ala Gly Gly Cys Thr Thr

785 790 795 800

Gly Gly Thr Cys Cys Ala Gly Cys Cys Thr Gly Gly Gly Gly Gly Gly

805 810 815

Thr Cys Cys Cys Thr Gly Ala Gly Ala Cys Thr Cys Thr Cys Cys Thr

820 825 830

Gly Thr Gly Cys Ala Gly Cys Cys Thr Cys Thr Gly Gly Ala Thr Thr

835 840 845

Cys Ala Cys Cys Ala Thr Cys Ala Gly Thr Ala Cys Cys Ala Ala Thr

850 855 860

Gly Cys Ala Ala Thr Gly Ala Gly Cys Thr Gly Gly Gly Thr Cys Cys

865 870 875 880

Gly Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala Gly Gly Gly Ala Ala

885 890 895

Gly Gly Gly Gly Cys Thr Gly Gly Ala Gly Thr Gly Gly Ala Thr Cys

900 905 910

Gly Gly Ala Gly Thr Cys Ala Thr Thr Ala Cys Thr Gly Gly Thr Cys

915 920 925

Gly Thr Gly Ala Thr Ala Thr Cys Ala Cys Ala Thr Ala Cys Thr Ala

930 935 940

Cys Gly Cys Gly Ala Gly Cys Thr Gly Gly Gly Cys Gly Ala Ala Ala

945 950 955 960

Gly Gly Cys Ala Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr

965 970 975

Cys Cys Ala Gly Ala Gly Ala Cys Ala Ala Thr Thr Cys Cys Ala Ala

980 985 990

Gly Ala Ala Cys Ala Cys Gly Cys Thr Gly Thr Ala Thr Cys Thr Thr

995 1000 1005

Cys Ala Ala Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys Thr Gly

1010 1015 1020

Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys Gly

1025 1030 1035

Gly Cys Thr Gly Thr Gly Thr Ala Thr Thr Ala Cys Thr Gly Thr

1040 1045 1050

Gly Cys Gly Ala Gly Ala Gly Ala Cys Gly Gly Thr Gly Gly Thr

1055 1060 1065

Thr Cys Thr Thr Cys Thr Gly Cys Thr Ala Thr Thr Ala Cys Thr

1070 1075 1080

Ala Gly Thr Ala Ala Cys Ala Ala Cys Ala Thr Thr Thr Gly Gly

1085 1090 1095

Gly Gly Cys Cys Ala Gly Gly Gly Ala Ala Cys Cys Cys Thr Gly

1100 1105 1110

Gly Thr Cys Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Cys Ala

1115 1120 1125

Gly Cys Thr Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Gly Cys

1130 1135 1140

Cys Cys Ala Thr Cys Gly Gly Thr Cys Thr Thr Cys Cys Cys Cys

1145 1150 1155

Cys Thr Gly Gly Cys Ala Cys Cys Cys Thr Cys Cys Thr Cys Cys

1160 1165 1170

Ala Ala Gly Ala Gly Cys Ala Cys Cys Thr Cys Thr Gly Gly Gly

1175 1180 1185

Gly Gly Cys Ala Cys Ala Gly Cys Gly Gly Cys Cys Cys Thr Gly

1190 1195 1200

Gly Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala Ala Gly

1205 1210 1215

Gly Ala Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Ala

1220 1225 1230

Cys Cys Gly Gly Thr Gly Ala Cys Gly Gly Thr Gly Thr Cys Gly

1235 1240 1245

Thr Gly Gly Ala Ala Cys Thr Cys Ala Gly Gly Cys Gly Cys Cys

1250 1255 1260

Cys Thr Gly Ala Cys Cys Ala Gly Cys Gly Gly Cys Gly Thr Gly

1265 1270 1275

Cys Ala Cys Ala Cys Cys Thr Thr Cys Cys Cys Gly Gly Cys Thr

1280 1285 1290

Gly Thr Cys Cys Thr Ala Cys Ala Gly Thr Cys Cys Thr Cys Ala

1295 1300 1305

Gly Gly Ala Cys Thr Cys Thr Ala Cys Thr Cys Cys Cys Thr Cys

1310 1315 1320

Ala Gly Cys Ala Gly Cys Gly Thr Gly Gly Thr Gly Ala Cys Cys

1325 1330 1335

Gly Thr Gly Cys Cys Cys Thr Cys Cys Ala Gly Cys Ala Gly Cys

1340 1345 1350

Thr Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala Gly Ala Cys Cys

1355 1360 1365

Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys Gly Thr Gly

1370 1375 1380

Ala Ala Thr Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala Gly Cys

1385 1390 1395

Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala Cys

1400 1405 1410

Ala Ala Gly Ala Gly Ala Gly Thr Thr Gly Ala Gly Cys Cys Cys

1415 1420 1425

Ala Ala Ala Thr Cys Thr Thr Gly Thr Gly Ala Cys Ala Ala Ala

1430 1435 1440

Ala Cys Thr Cys Ala Cys Ala Cys Ala Thr Gly Cys Cys Cys Ala

1445 1450 1455

Cys Cys Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala Cys Cys Thr

1460 1465 1470

Gly Ala Ala Gly Cys Cys Gly Cys Gly Gly Gly Gly Gly Gly Ala

1475 1480 1485

Cys Cys Gly Thr Cys Ala Gly Thr Cys Thr Thr Cys Cys Thr Cys

1490 1495 1500

Thr Thr Cys Cys Cys Cys Cys Cys Ala Ala Ala Ala Cys Cys Cys

1505 1510 1515

Ala Ala Gly Gly Ala Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly

1520 1525 1530

Ala Thr Cys Thr Cys Cys Cys Gly Gly Ala Cys Cys Cys Cys Thr

1535 1540 1545

Gly Ala Gly Gly Thr Cys Ala Cys Ala Thr Gly Cys Gly Thr Gly

1550 1555 1560

Gly Thr Gly Gly Thr Gly Gly Ala Cys Gly Thr Gly Ala Gly Cys

1565 1570 1575

Cys Ala Cys Gly Ala Ala Gly Ala Cys Cys Cys Thr Gly Ala Gly

1580 1585 1590

Gly Thr Cys Ala Ala Gly Thr Thr Cys Ala Ala Cys Thr Gly Gly

1595 1600 1605

Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys Gly Thr Gly

1610 1615 1620

Gly Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr Gly Cys Cys

1625 1630 1635

Ala Ala Gly Ala Cys Ala Ala Ala Gly Cys Cys Gly Cys Gly Gly

1640 1645 1650

Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Gly Cys Cys

1655 1660 1665

Ala Gly Cys Ala Cys Gly Thr Ala Cys Cys Gly Thr Gly Thr Gly

1670 1675 1680

Gly Thr Cys Ala Gly Cys Gly Thr Cys Cys Thr Cys Ala Cys Cys

1685 1690 1695

Gly Thr Cys Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys

1700 1705 1710

Thr Gly Gly Cys Thr Gly Ala Ala Thr Gly Gly Cys Ala Ala Gly

1715 1720 1725

Gly Ala Gly Thr Ala Cys Ala Ala Gly Thr Gly Cys Gly Cys Gly

1730 1735 1740

Gly Thr Cys Thr Cys Cys Ala Ala Cys Ala Ala Ala Gly Cys Cys

1745 1750 1755

Cys Thr Cys Cys Cys Ala Gly Cys Cys Cys Cys Cys Ala Thr Cys

1760 1765 1770

Gly Ala Gly Ala Ala Ala Ala Cys Cys Ala Thr Cys Thr Cys Cys

1775 1780 1785

Ala Ala Ala Gly Cys Cys Ala Ala Ala Gly Gly Gly Cys Ala Gly

1790 1795 1800

Cys Cys Cys Cys Gly Ala Gly Ala Ala Cys Cys Ala Cys Ala Gly

1805 1810 1815

Gly Thr Gly Thr Gly Thr Ala Cys Cys Cys Thr Gly Cys Cys Cys

1820 1825 1830

Cys Cys Ala Thr Cys Cys Cys Gly Gly Gly Ala Thr Gly Ala Gly

1835 1840 1845

Cys Thr Gly Ala Cys Cys Ala Ala Gly Ala Ala Cys Cys Ala Gly

1850 1855 1860

Gly Thr Cys Ala Gly Cys Cys Thr Gly Thr Cys Cys Thr Gly Cys

1865 1870 1875

Gly Cys Cys Gly Thr Cys Ala Ala Ala Gly Gly Cys Thr Thr Cys

1880 1885 1890

Thr Ala Thr Cys Cys Cys Ala Gly Cys Gly Ala Cys Ala Thr Cys

1895 1900 1905

Gly Cys Cys Gly Thr Gly Gly Ala Gly Thr Gly Gly Gly Ala Gly

1910 1915 1920

Ala Gly Cys Ala Ala Thr Gly Gly Gly Cys Ala Gly Cys Cys Gly

1925 1930 1935

Gly Ala Gly Ala Ala Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly

1940 1945 1950

Ala Cys Cys Ala Cys Gly Cys Cys Thr Cys Cys Cys Gly Thr Gly

1955 1960 1965

Cys Thr Gly Gly Ala Cys Thr Cys Cys Gly Ala Cys Gly Gly Cys

1970 1975 1980

Thr Cys Cys Thr Thr Cys Thr Thr Cys Cys Thr Cys Gly Thr Gly

1985 1990 1995

Ala Gly Cys Ala Ala Gly Cys Thr Cys Ala Cys Cys Gly Thr Gly

2000 2005 2010

Gly Ala Cys Ala Ala Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly

2015 2020 2025

Cys Ala Gly Cys Ala Gly Gly Gly Gly Ala Ala Cys Gly Thr Cys

2030 2035 2040

Thr Thr Cys Thr Cys Ala Thr Gly Cys Thr Cys Cys Gly Thr Gly

2045 2050 2055

Ala Thr Gly Cys Ala Thr Gly Ala Gly Gly Cys Thr Cys Thr Gly

2060 2065 2070

Cys Ala Cys Ala Ala Cys Cys Ala Cys Thr Ala Cys Ala Cys Gly

2075 2080 2085

Cys Ala Gly Ala Ala Gly Ala Gly Cys Cys Thr Cys Thr Cys Cys

2090 2095 2100

Cys Thr Gly Thr Cys Thr Cys Cys Gly Gly Gly Thr Ala Ala Ala

2105 2110 2115

Thr Ala Gly

2120

<210> 139

<211> 707

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 139

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Lys

705

<210> 140

<211> 2124

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 140

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccggggtaa atag 2124

<210> 141

<211> 961

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 141

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp

145 150 155 160

Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp

165 170 175

Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu

180 185 190

Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser

195 200 205

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys

210 215 220

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr

225 230 235 240

Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Leu Val Glu

705 710 715 720

Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys

725 730 735

Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg

740 745 750

Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly

755 760 765

Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser

770 775 780

Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg

785 790 795 800

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser

805 810 815

Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly

820 825 830

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

835 840 845

Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser

850 855 860

Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg

865 870 875 880

Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

885 890 895

Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe

900 905 910

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu

915 920 925

Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly

930 935 940

Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile

945 950 955 960

Lys

<210> 142

<211> 2886

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 142

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300

gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420

ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480

tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540

tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600

gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660

atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720

atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg tggagggtcc ggcggtggtg gatcccggtc gctggtggag 2160

tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtac tgcctctgga 2220

ttcaccatca gtagctacca catgcagtgg gtccggcagg cacctgggaa gtgcctggag 2280

tacatcggaa ccattagtag tggtggtaat gtatactacg caagctccgc tagaggcaga 2340

ttcaccatct ccagaccctc gtccaagaac acggtggatc ttcaaatgaa cagcctgaga 2400

gccgaggaca cggctgtgta ttactgtgcg agagactctg gttatagtga tcctatgtgg 2460

ggccagggaa ccctggtcac cgtctcttca ggcggtggcg gtagtggggg aggcggttct 2520

ggcggcggag ggtccggcgg tggaggatca gacgttgtga tgacccagtc tccatcttcc 2580

gtgtctgcat ctgtaggaga cagagtcacc atcacctgtc aggccagtca gaacattagg 2640

acttacttat cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct 2700

gcagccaatc tggcatctgg ggtcccatca aggttcagcg gcagtggatc tgggacagat 2760

ttcactctca ccatcagcga cttggaacct ggcgatgctg caacttacta ttgtcagtct 2820

acctatcttg gtactgatta tgttggcggt gctttcggct gtgggaccaa ggtggagatc 2880

aaatga 2886

<210> 143

<211> 707

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 143

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Lys

705

<210> 144

<211> 2124

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 144

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccggggtaa atag 2124

<210> 145

<211> 706

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 145

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp

145 150 155 160

Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp

165 170 175

Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu

180 185 190

Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser

195 200 205

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys

210 215 220

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr

225 230 235 240

Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Lys

705

<210> 146

<211> 2121

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 146

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300

gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420

ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480

tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540

tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600

gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660

atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720

atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtaaata g 2121

<210> 147

<211> 968

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 147

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu

705 710 715 720

Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu

725 730 735

Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys

740 745 750

Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Ala Cys Ile

755 760 765

Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly

770 775 780

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln

785 790 795 800

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

805 810 815

Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr

820 825 830

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

835 840 845

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln

850 855 860

Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr

865 870 875 880

Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln

885 890 895

Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu

900 905 910

Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu

915 920 925

Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr

930 935 940

Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly

945 950 955 960

Cys Gly Thr Lys Val Glu Ile Lys

965

<210> 148

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 148

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga ggtgcagctg 2160

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc 2220

tctggattct ccttcagtag cgggtacgac atgtgctggg tccgccaggc tccagggaag 2280

tgcctggagt ggatcgcatg cattgctgct ggtagtgctg gtatcactta cgacgcgaac 2340

tgggcgaaag gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa 2400

atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgagatc ggcgttttcg 2460

ttcgactacg ccatggacct ctggggccag ggaaccctgg tcaccgtctc gtctggtgga 2520

ggcggttcag gcggaggtgg aagtggtggt ggcggctctg gaggcggcgg atctgacatc 2580

cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact 2640

tgccaggcca gtcagagcat tagttcccac ttaaactggt atcagcagaa accagggaaa 2700

gcccctaagc tcctgatcta taaggcatcc actctggcat ctggggtccc atcaaggttc 2760

agcggcagtg gatctgggac agaatttact ctcaccatca gcagcctgca gcctgatgat 2820

tttgcaactt attactgcca acagggttat agttggggta atgttgataa tgttttcggc 2880

tgcgggacca aggtggagat caaatag 2907

<210> 149

<211> 961

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 149

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp

145 150 155 160

Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp

165 170 175

Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu

180 185 190

Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser

195 200 205

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys

210 215 220

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr

225 230 235 240

Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

260 265 270

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

275 280 285

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

290 295 300

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

305 310 315 320

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

325 330 335

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

340 345 350

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

355 360 365

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

370 375 380

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

385 390 395 400

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

405 410 415

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

420 425 430

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

435 440 445

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

450 455 460

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

465 470 475 480

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly

485 490 495

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

500 505 510

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

515 520 525

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

530 535 540

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg

545 550 555 560

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

565 570 575

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

580 585 590

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys

595 600 605

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

610 615 620

Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

625 630 635 640

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

645 650 655

Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp

660 665 670

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

675 680 685

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

690 695 700

Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Ser Leu Val Glu

705 710 715 720

Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys

725 730 735

Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His Met Gln Trp Val Arg

740 745 750

Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly Thr Ile Ser Ser Gly

755 760 765

Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly Arg Phe Thr Ile Ser

770 775 780

Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln Met Asn Ser Leu Arg

785 790 795 800

Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Ser Gly Tyr Ser

805 810 815

Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly

820 825 830

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly

835 840 845

Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser

850 855 860

Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg

865 870 875 880

Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

885 890 895

Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe

900 905 910

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu

915 920 925

Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly

930 935 940

Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile

945 950 955 960

Lys

<210> 150

<211> 2886

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 150

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300

gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420

ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480

tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540

tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600

gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660

atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720

atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga ggtgcagctg 780

gtggagtctg ggggaggctt ggtccagcct ggggggtccc tgagactctc ctgtgcagcc 840

tctggattca ccatcagtac caatgcaatg agctgggtcc gccaggctcc agggaagggg 900

ctggagtgga tcggagtcat tactggtcgt gatatcacat actacgcgag ctgggcgaaa 960

ggcagattca ccatctccag agacaattcc aagaacacgc tgtatcttca aatgaacagc 1020

ctgagagccg aggacacggc tgtgtattac tgtgcgagag acggtggttc ttctgctatt 1080

actagtaaca acatttgggg ccagggaacc ctggtcaccg tgtcctcagc tagcaccaag 1140

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc 1200

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc 1260

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc 1320

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac 1380

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac 1440

aaaactcaca catgcccacc gtgcccagca cctgaagccg cggggggacc gtcagtcttc 1500

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc 1560

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc 1620

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacgccag cacgtaccgt 1680

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc 1740

gcggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg 1800

cagccccgag aaccacaggt gtgtaccctg cccccatccc gggatgagct gaccaagaac 1860

caggtcagcc tgtcctgcgc cgtcaaaggc ttctatccca gcgacatcgc cgtggagtgg 1920

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1980

ggctccttct tcctcgtgag caagctcacc gtggacaaga gcaggtggca gcaggggaac 2040

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc 2100

tccctgtctc cgggtggcgg tggagggtcc ggcggtggtg gatcccggtc gctggtggag 2160

tctgggggag gcttggtcca gcctgggggg tccctgagac tctcctgtac tgcctctgga 2220

ttcaccatca gtagctacca catgcagtgg gtccggcagg cacctgggaa gtgcctggag 2280

tacatcggaa ccattagtag tggtggtaat gtatactacg caagctccgc tagaggcaga 2340

ttcaccatct ccagaccctc gtccaagaac acggtggatc ttcaaatgaa cagcctgaga 2400

gccgaggaca cggctgtgta ttactgtgcg agagactctg gttatagtga tcctatgtgg 2460

ggccagggaa ccctggtcac cgtctcttca ggcggtggcg gtagtggggg aggcggttct 2520

ggcggcggag ggtccggcgg tggaggatca gacgttgtga tgacccagtc tccatcttcc 2580

gtgtctgcat ctgtaggaga cagagtcacc atcacctgtc aggccagtca gaacattagg 2640

acttacttat cctggtatca gcagaaacca gggaaagccc ctaagctcct gatctatgct 2700

gcagccaatc tggcatctgg ggtcccatca aggttcagcg gcagtggatc tgggacagat 2760

ttcactctca ccatcagcga cttggaacct ggcgatgctg caacttacta ttgtcagtct 2820

acctatcttg gtactgatta tgttggcggt gctttcggct gtgggaccaa ggtggagatc 2880

aaatga 2886

<210> 151

<211> 968

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 151

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala

260 265 270

Ser Val Gly Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile

275 280 285

Ser Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys

290 295 300

Leu Leu Ile Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg

305 310 315 320

Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser

325 330 335

Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr

340 345 350

Phe Ile Ser Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val

355 360 365

Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro

370 375 380

Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu

385 390 395 400

Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn

405 410 415

Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser

420 425 430

Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala

435 440 445

Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly

450 455 460

Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu

705 710 715 720

Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu

725 730 735

Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys

740 745 750

Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile Ala Cys Ile

755 760 765

Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly

770 775 780

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln

785 790 795 800

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

805 810 815

Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr

820 825 830

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

835 840 845

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln

850 855 860

Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr

865 870 875 880

Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln

885 890 895

Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu

900 905 910

Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu

915 920 925

Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr

930 935 940

Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly

945 950 955 960

Cys Gly Thr Lys Val Glu Ile Lys

965

<210> 152

<211> 2907

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 152

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggct gtgggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgaga ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga agtgcctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt gtcgacaggc ggtggagggt ccggcggtgg tggatcagac 780

gtcgtgatga cccagtctcc ttccaccctg tctgcatctg taggagacag agtcaccatc 840

aattgccaag ccagtgagag cattagcagt tggttagcct ggtatcagca gaaaccaggg 900

aaagccccta agctcctgat ctatgaagca tccaaactgg catctggggt cccatcaagg 960

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat 1020

gattttgcaa cttattactg ccaaggctat ttttatttta ttagtcgtac ttatgtaaat 1080

tctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 1140

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 1200

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 1260

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 1320

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 1380

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtggaggc 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag 1860

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccgggtgg cggtggaggg tccggcggtg gtggatccga ggtgcagctg 2160

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc 2220

tctggattct ccttcagtag cgggtacgac atgtgctggg tccgccaggc tccagggaag 2280

tgcctggagt ggatcgcatg cattgctgct ggtagtgctg gtatcactta cgacgcgaac 2340

tgggcgaaag gccggttcac catctccaga gacaattcca agaacacgct gtatctgcaa 2400

atgaacagcc tgagagccga ggacacggcc gtatattact gtgcgagatc ggcgttttcg 2460

ttcgactacg ccatggacct ctggggccag ggaaccctgg tcaccgtctc gtctggtgga 2520

ggcggttcag gcggaggtgg aagtggtggt ggcggctctg gaggcggcgg atctgacatc 2580

cagatgaccc agtctccttc caccctgtct gcatctgtag gagacagagt caccatcact 2640

tgccaggcca gtcagagcat tagttcccac ttaaactggt atcagcagaa accagggaaa 2700

gcccctaagc tcctgatcta taaggcatcc actctggcat ctggggtccc atcaaggttc 2760

agcggcagtg gatctgggac agaatttact ctcaccatca gcagcctgca gcctgatgat 2820

tttgcaactt attactgcca acagggttat agttggggta atgttgataa tgttttcggc 2880

tgcgggacca aggtggagat caaatag 2907

<210> 153

<211> 468

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 153

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala Ser Thr Lys Gly

130 135 140

Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly

145 150 155 160

Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val

165 170 175

Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe

180 185 190

Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val

195 200 205

Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val

210 215 220

Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys

225 230 235 240

Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala

245 250 255

Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr

260 265 270

Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val

275 280 285

Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val

290 295 300

Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser

305 310 315 320

Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu

325 330 335

Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala

340 345 350

Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro

355 360 365

Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln

370 375 380

Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala

385 390 395 400

Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr

405 410 415

Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu

420 425 430

Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser

435 440 445

Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser

450 455 460

Leu Ser Pro Gly

465

<210> 154

<211> 1407

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 154

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 420

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 480

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 660

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 720

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1020

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1080

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1140

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1260

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1380

aagagcctct ccctgtctcc gggttaa 1407

<210> 155

<211> 474

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 155

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala

130 135 140

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

145 150 155 160

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

165 170 175

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

180 185 190

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

195 200 205

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

210 215 220

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

225 230 235 240

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

245 250 255

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

260 265 270

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

275 280 285

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

290 295 300

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

305 310 315 320

Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

325 330 335

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

340 345 350

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

355 360 365

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp

370 375 380

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

385 390 395 400

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

405 410 415

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

420 425 430

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

435 440 445

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

450 455 460

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

465 470

<210> 156

<211> 1425

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 156

ttcctaaact cattattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc 60

ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt 120

aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta 180

tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta 240

gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac 300

ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa 360

ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgcgt 420

acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 480

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 540

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 600

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 660

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 720

ttcaacaggg gagagtgtgg aggcgacaaa actcacacat gcccaccgtg cccagcacct 780

gaagccgcgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960

gagggagcagt acgccagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020

tggctgaatg gcaaggagta caagtgcgcg gtctccaaca aagccctccc agcccccatc 1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140

ccatgtcggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc 1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg 1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttaa 1425

<210> 157

<211> 728

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 157

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr

115 120 125

Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro

130 135 140

Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser

145 150 155 160

Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu

165 170 175

Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp

180 185 190

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile

260 265 270

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys

275 280 285

Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr

290 295 300

Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val

305 310 315 320

Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His

325 330 335

Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu

340 345 350

Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln

355 360 365

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu

370 375 380

Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala

385 390 395 400

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

405 410 415

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

420 425 430

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

435 440 445

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

450 455 460

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

465 470 475 480

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

485 490 495

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly

725

<210> 158

<211> 2187

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 158

gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60

attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120

gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180

cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240

gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300

aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360

cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420

cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480

acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540

ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600

agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660

gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720

ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggttaa 2187

<210> 159

<211> 474

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 159

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala

130 135 140

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

145 150 155 160

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

165 170 175

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

180 185 190

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

195 200 205

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

210 215 220

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

225 230 235 240

Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro

245 250 255

Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro

260 265 270

Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr

275 280 285

Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn

290 295 300

Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg

305 310 315 320

Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val

325 330 335

Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser

340 345 350

Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys

355 360 365

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp

370 375 380

Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe

385 390 395 400

Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu

405 410 415

Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe

420 425 430

Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly

435 440 445

Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr

450 455 460

Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

465 470

<210> 160

<211> 1425

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 160

ttcctaaact cattattcaa ccaagaagtt caaattccct tgaccgaaag ttactgtggc 60

ccatgtccta aaaactggat atgttacaaa aataactgct accaattttt tgatgagagt 120

aaaaactggt atgagagcca ggcttcttgt atgtctcaaa atgccagcct tctgaaagta 180

tacagcaaag aggaccagga tttacttaaa ctggtgaagt catatcattg gatgggacta 240

gtacacattc caacaaatgg atcttggcag tgggaagatg gctccattct ctcacccaac 300

ctactaacaa taattgaaat gcagaaggga gactgtgcac tctatgcctc gagctttaaa 360

ggctatatag aaaactgttc aactccaaat acgtacatct gcatgcaaag gactgtgcgt 420

acggtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 480

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 540

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 600

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 660

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 720

ttcaacaggg gagagtgtgg aggcgacaaa actcacacat gcccaccgtg cccagcacct 780

gaagccgcgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg 840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag 900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg 960

gagggagcagt acgccagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac 1020

tggctgaatg gcaaggagta caagtgcgcg gtctccaaca aagccctccc agcccccatc 1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc 1140

ccatgtcggg atgagctgac caagaaccag gtcagcctgt ggtgcctggt caaaggcttc 1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag 1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctatagcaa gctcaccgtg 1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg 1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gttaa 1425

<210> 161

<211> 728

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 161

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr

115 120 125

Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro

130 135 140

Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser

145 150 155 160

Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu

165 170 175

Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp

180 185 190

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile

260 265 270

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys

275 280 285

Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr

290 295 300

Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val

305 310 315 320

Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His

325 330 335

Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu

340 345 350

Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln

355 360 365

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu

370 375 380

Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala

385 390 395 400

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

405 410 415

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

420 425 430

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

435 440 445

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

450 455 460

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

465 470 475 480

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

485 490 495

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly

725

<210> 162

<211> 2187

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 162

gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60

attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120

gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180

cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240

gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300

aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360

cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420

cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480

acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540

ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600

agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660

gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720

ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggttaa 2187

<210> 163

<211> 728

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 163

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly

100 105 110

Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu

115 120 125

Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu

130 135 140

Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val

145 150 155 160

Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His

165 170 175

Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg

180 185 190

Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met

195 200 205

Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met

210 215 220

Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val

225 230 235 240

Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu

245 250 255

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr

260 265 270

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr

275 280 285

Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys

290 295 300

Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln

305 310 315 320

Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His

325 330 335

Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser

340 345 350

Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu

355 360 365

Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn

370 375 380

Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser

385 390 395 400

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

405 410 415

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

420 425 430

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

435 440 445

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

450 455 460

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

465 470 475 480

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

485 490 495

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly

725

<210> 164

<211> 2187

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 164

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360

agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420

acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480

ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540

gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600

aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660

tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720

acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020

ggatcttggc agtgggaaga tggctccat ctctcaccca acctactaac aataattgaa 1080

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140

tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500

ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggttaa 2187

<210> 165

<211> 728

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 165

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr

115 120 125

Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro

130 135 140

Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser

145 150 155 160

Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu

165 170 175

Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp

180 185 190

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile

260 265 270

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys

275 280 285

Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr

290 295 300

Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val

305 310 315 320

Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His

325 330 335

Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu

340 345 350

Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln

355 360 365

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu

370 375 380

Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala

385 390 395 400

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

405 410 415

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

420 425 430

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

435 440 445

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

450 455 460

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

465 470 475 480

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

485 490 495

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly

725

<210> 166

<211> 2187

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 166

gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60

attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120

gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180

cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240

gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300

aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360

cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420

cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480

acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtggggggtc 540

ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600

agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660

gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720

ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggttaa 2187

<210> 167

<211> 990

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 167

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly

100 105 110

Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu

115 120 125

Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu

130 135 140

Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val

145 150 155 160

Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His

165 170 175

Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg

180 185 190

Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met

195 200 205

Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met

210 215 220

Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val

225 230 235 240

Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu

245 250 255

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr

260 265 270

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr

275 280 285

Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys

290 295 300

Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln

305 310 315 320

Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His

325 330 335

Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser

340 345 350

Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu

355 360 365

Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn

370 375 380

Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser

385 390 395 400

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

405 410 415

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

420 425 430

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

435 440 445

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

450 455 460

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

465 470 475 480

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

485 490 495

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

725 730 735

Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro

740 745 750

Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser

755 760 765

Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

770 775 780

Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp

785 790 795 800

Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys

805 810 815

Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala

820 825 830

Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp

835 840 845

Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

850 855 860

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

865 870 875 880

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

885 890 895

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His

900 905 910

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

915 920 925

Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

930 935 940

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

945 950 955 960

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn

965 970 975

Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

980 985 990

<210> 168

<211> 2973

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 168

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360

agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420

acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480

ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540

gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600

aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660

tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720

acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020

ggatcttggc agtgggaaga tggctccat ctctcaccca acctactaac aataattgaa 1080

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140

tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500

ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280

gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340

gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400

gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520

ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580

ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700

atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760

gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880

gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940

ttcggctgcg ggaccaaggt ggagatcaaa tag 2973

<210> 169

<211> 984

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 169

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr

115 120 125

Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro

130 135 140

Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser

145 150 155 160

Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu

165 170 175

Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp

180 185 190

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile

260 265 270

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys

275 280 285

Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr

290 295 300

Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val

305 310 315 320

Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His

325 330 335

Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu

340 345 350

Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln

355 360 365

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu

370 375 380

Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala

385 390 395 400

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

405 410 415

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

420 425 430

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

435 440 445

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

450 455 460

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

465 470 475 480

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

485 490 495

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

725 730 735

Gly Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

740 745 750

Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser

755 760 765

Tyr His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr

770 775 780

Ile Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala

785 790 795 800

Arg Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp

805 810 815

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

820 825 830

Ala Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu

835 840 845

Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly

850 855 860

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser

865 870 875 880

Pro Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

885 890 895

Gln Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys

900 905 910

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala

915 920 925

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe

930 935 940

Thr Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr

945 950 955 960

Cys Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly

965 970 975

Cys Gly Thr Lys Val Glu Ile Lys

980

<210> 170

<211> 2955

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 170

gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60

attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120

gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180

cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240

gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300

aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360

cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420

cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480

acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtgggggtc 540

ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600

agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660

gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720

ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atcccggtcg 2220

ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtact 2280

gcctctggat tcaccatcag tagctaccac atgcagtggg tccggcaggc acctgggaag 2340

tgcctggagt acatcggaac cattagtagt ggtggtaatg tatactacgc aagctccgct 2400

agaggcagat tcaccatctc cagaccctcg tccaagaaca cggtggatct tcaaatgaac 2460

agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagactctgg ttatagtgat 2520

cctatgtggg gccagggaac cctggtcacc gtctcttcag gcggtggcgg tagtggggga 2580

ggcggttctg gcggcggagg gtccggcggt ggagatcag acgttgtgat gacccagtct 2640

ccatcttccg tgtctgcatc tgtaggagac agagtcacca tcacctgtca ggccagtcag 2700

aacattagga cttacttatc ctggtatcag cagaaaccag ggaaagcccc taagctcctg 2760

atctatgctg cagccaatct ggcatctggg gtcccatcaa ggttcagcgg cagtggatct 2820

gggacagatt tcactctcac catcagcgac ttggaacctg gcgatgctgc aacttactat 2880

tgtcagtcta cctatcttgg tactgattat gttggcggtg ctttcggctg tgggaccaag 2940

gtggagatca aatga 2955

<210> 171

<211> 990

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 171

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly

100 105 110

Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu

115 120 125

Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu

130 135 140

Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val

145 150 155 160

Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His

165 170 175

Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg

180 185 190

Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met

195 200 205

Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met

210 215 220

Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val

225 230 235 240

Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu

245 250 255

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr

260 265 270

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr

275 280 285

Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys

290 295 300

Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln

305 310 315 320

Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His

325 330 335

Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser

340 345 350

Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu

355 360 365

Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn

370 375 380

Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser

385 390 395 400

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

405 410 415

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

420 425 430

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

435 440 445

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

450 455 460

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

465 470 475 480

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

485 490 495

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

725 730 735

Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro

740 745 750

Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser

755 760 765

Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

770 775 780

Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp

785 790 795 800

Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys

805 810 815

Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala

820 825 830

Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp

835 840 845

Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

850 855 860

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

865 870 875 880

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

885 890 895

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His

900 905 910

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

915 920 925

Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

930 935 940

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

945 950 955 960

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn

965 970 975

Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

980 985 990

<210> 172

<211> 2973

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 172

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360

agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420

acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480

ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540

gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600

aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660

tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720

acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020

ggatcttggc agtgggaaga tggctccat ctctcaccca acctactaac aataattgaa 1080

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140

tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500

ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280

gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340

gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400

gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520

ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580

ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700

atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760

gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880

gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940

ttcggctgcg ggaccaaggt ggagatcaaa tag 2973

<210> 173

<211> 1015

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 173

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Gly Gly Gly Gly Ser

130 135 140

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe

145 150 155 160

Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser

165 170 175

Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys

180 185 190

Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser

195 200 205

Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp

210 215 220

Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val

225 230 235 240

His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu

245 250 255

Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala

260 265 270

Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro

275 280 285

Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Val Asp Gly Gly Gly Gly

290 295 300

Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly

305 310 315 320

Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly

325 330 335

Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly

340 345 350

Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr

355 360 365

Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser

370 375 380

Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr

385 390 395 400

Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser

405 410 415

Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser

420 425 430

Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr

435 440 445

Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro

450 455 460

Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val

465 470 475 480

His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser

485 490 495

Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile

500 505 510

Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val

515 520 525

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

530 535 540

Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

545 550 555 560

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

565 570 575

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

580 585 590

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

595 600 605

Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

610 615 620

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala

625 630 635 640

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

645 650 655

Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

660 665 670

Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser

675 680 685

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

690 695 700

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val

705 710 715 720

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

725 730 735

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

740 745 750

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly

755 760 765

Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

770 775 780

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr

785 790 795 800

His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile

805 810 815

Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg

820 825 830

Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu

835 840 845

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

850 855 860

Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val

865 870 875 880

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

885 890 895

Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro

900 905 910

Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln

915 920 925

Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro

930 935 940

Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser

945 950 955 960

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

965 970 975

Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys

980 985 990

Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Cys

995 1000 1005

Gly Thr Lys Val Glu Ile Lys

1010 1015

<210> 174

<211> 3048

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 174

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgga 420

ggcggtggct caggcggagg cggctcagga ggtggcggtt caggaggcgg cggatctttc 480

ctaaactcat tattcaacca agaagttcaa attcccttga ccgaaagtta ctgtggccca 540

tgtcctaaaa actggatatg ttacaaaaat aactgctacc aattttttga tgagagtaaa 600

aactggtatg agagccaggc ttcttgtatg tctcaaaatg ccagccttct gaaagtatac 660

agcaaagagg accaggattt acttaaactg gtgaagtcat atcattggat gggactagta 720

cacattccaa caaatggatc ttggcagtgg gaagatggct ccattctctc acccaaccta 780

ctaacaataa ttgaaatgca gaagggagac tgtgcactct atgcctcgag ctttaaaggc 840

tatatagaaa actgttcaac tccaaatacg tacatctgca tgcaaaggac tgtggtcgac 900

ggcggtggag ggtccggcgg tggtggatca gaggtgcagc tggtggagtc tgggggaggc 960

ttggtccagc ctggggggtc cctgagactc tcctgtgcag cctctggatt caccatcagt 1020

accaatgcaa tgagctgggt ccgccaggct ccagggaagg ggctggagtg gatcggagtc 1080

attactggtc gtgatatcac atactacgcg agctgggcga aaggcagatt caccatctcc 1140

agagacaatt ccaagaacac gctgtatctt caaatgaaca gcctgagagc cgaggacacg 1200

gctgtgtatt actgtgcgag agacggtggt tcttctgcta ttactagtaa caacatttgg 1260

ggccagggaa ccctggtcac cgtgtcctca gctagcacca agggcccatc ggtcttcccc 1320

ctggcaccct cctccaagag cacctctggg ggcacagcgg ccctgggctg cctggtcaag 1380

gactacttcc ccgaaccggt gacggtgtcg tggaactcag gcgccctgac cagcggcgtg 1440

cacaccttcc cggctgtcct acagtcctca ggactctact ccctcagcag cgtggtgacc 1500

gtgccctcca gcagcttggg cacccagacc tacatctgca acgtgaatca caagcccagc 1560

aacaccaagg tggacaagag agttgagccc aaatcttgtg acaaaactca cacatgccca 1620

ccgtgcccag cacctgaagc cgcgggggga ccgtcagtct tcctcttccc cccaaaaccc 1680

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc 1740

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc 1800

aagacaaagc cgcgggagga gcagtacgcc agcacgtacc gtgtggtcag cgtcctcacc 1860

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcgcggtctc caacaaagcc 1920

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag 1980

gtgtgtaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgtcctgc 2040

gccgtcaaag gcttctatcc cagcgacatc gccgtggagt ggggagagcaa tgggcagccg 2100

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctcgtg 2160

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg 2220

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtggc 2280

ggtggagggt ccggcggtgg tggatcccgg tcgctggtgg agtctggggg aggcttggtc 2340

cagcctgggg ggtccctgag actctcctgt actgcctctg gattcaccat cagtagctac 2400

cacatgcagt gggtccggca ggcacctggg aagtgcctgg agtacatcgg aaccattagt 2460

agtggtggta atgtatacta cgcaagctcc gctagaggca gattcaccat ctccagaccc 2520

tcgtccaaga acacggtgga tcttcaaatg aacagcctga gagccgagga cacggctgtg 2580

tattactgtg cgagagactc tggttatagt gatcctatgt ggggccaggg aaccctggtc 2640

accgtctctt caggcggtgg cggtagtggg ggaggcggtt ctggcggcgg agggtccggc 2700

ggtggaggat cagacgttgt gatgacccag tctccatctt ccgtgtctgc atctgtagga 2760

gacagagtca ccatcacctg tcaggccagt cagaacatta ggacttactt atcctggtat 2820

cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcagccaa tctggcatct 2880

ggggtcccat caaggttcag cggcagtgga tctgggacag atttcactct caccatcagc 2940

gacttggaac ctggcgatgc tgcaacttac tattgtcagt ctacctatct tggtactgat 3000

tatgttggcg gtgctttcgg ctgtgggacc aaggtggaga tcaaatga 3048

<210> 175

<211> 965

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 175

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val

115 120 125

Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu

130 135 140

Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met

145 150 155 160

Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu

165 170 175

Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys

180 185 190

Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu

195 200 205

Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

210 215 220

Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr

225 230 235 240

Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

260 265 270

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

275 280 285

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

290 295 300

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

325 330 335

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

340 345 350

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

355 360 365

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

370 375 380

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

385 390 395 400

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

405 410 415

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

420 425 430

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

435 440 445

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

450 455 460

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

610 615 620

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly

690 695 700

Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser

705 710 715 720

Pro Ser Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys

725 730 735

Gln Ala Ser Gln Ser Ile Ser Ser His Leu Asn Trp Tyr Gln Gln Lys

740 745 750

Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Thr Leu Ala

755 760 765

Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe

770 775 780

Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr

785 790 795 800

Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val Asp Asn Val Phe Gly Gly

805 810 815

Gly Thr Lys Val Thr Val Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly

820 825 830

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu

835 840 845

Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser

850 855 860

Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly Tyr Asp Met Cys Trp

865 870 875 880

Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Cys Ile Ala

885 890 895

Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn Trp Ala Lys Gly Arg

900 905 910

Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met

915 920 925

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Ser

930 935 940

Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr Leu

945 950 955 960

Val Thr Val Ser Ser

965

<210> 176

<211> 2898

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 176

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtcctagg cggtggcggt agtgggggag gcggttctgg cggcggaggg 360

tccggcggtg gaggatcaca ggtcacattg aaggaatctg gccccggcct tgttcagcca 420

ggacagaccc ttagcctcac ctgtgccttc agtggttttt ctcttagcac tagcggtatg 480

ggggtcggct ggattcggca gcctcccggc aaaggtcttg agtggttggc tcacatttgg 540

tgggacgacg acaaacggta taatcctgcc ttgaaaagtc ggctgaccat tagtaaggat 600

acctcaaaaa atcaagtgta cttgcaaatg aatagccttg acgccgagga tacggctgta 660

tattattgcg cgcggatgga actctggtct tactactttg attattgggg gcaggggact 720

ctcgtcacgg tctcgagcgg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840

gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900

aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020

acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080

ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380

ggcctgagct cgcccgtcac aaagagcttc aacagggag agtgtggagg cgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtacac cctgccccca agccgggatg agctgaccaa gaaccaggtc 1860

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aacagattca cgcagaagag cctctccctg 2100

tctccgggtg gcggtggagg gtccggcggt ggtggatccg acattcagat gacacagtca 2160

ccgtctacgc tctcagcctc agtaggcgat agggtgacta tcacctgcca agcctcccaa 2220

tctataagtt cacacctcaa ctggtatcaa cagaaacccg gtaaagcacc gaagctgctc 2280

atctacaagg catcaactct tgcctcaggt gtgcctagtc gcttctccgg gagcggctcc 2340

ggtactgagt ttactttgac gatatcttcc ctccaacccg acgacttcgc cacatactat 2400

tgtcagcagg gttatagttg gggaaatgtt gacaatgtgt ttggaggggg aacgaaagtg 2460

actgtgttgg gagggggagg aagtggcggc ggcggaagcg gaggtggtgg ctccggcggg 2520

ggtggaagcg aagtgcaatt gctcgaaagt ggtggcggac ttgtgcaacc tggtggaagc 2580

ctctcactct cttgcgcggc gagtggtttt agcttcagta gcggctacga tatgtgctgg 2640

gtaagacagg ctcctggtaa aggccttgag tggattgcgt gtatcgccgc cgggtctgct 2700

ggtataacat acgatgcaaa ctgggcgaaa gggcgcttca caatctccag ggacaactca 2760

aaaaatacat tgtacctcca gatgaatagc ctgagagccg aagacaccgc agtctactat 2820

tgcgcaaggt cagcatttag cttcgattat gcaatggatc tttggggcca ggggacgctc 2880

gtcaccgtct catcttga 2898

<210> 177

<211> 1300

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 177

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Leu Thr Val Leu

100 105 110

Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr

115 120 125

Lys Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro

130 135 140

Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser

145 150 155 160

Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu

165 170 175

Trp Val Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp

180 185 190

Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val

195 200 205

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

210 215 220

Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp

225 230 235 240

Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly

245 250 255

Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile

260 265 270

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys

275 280 285

Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr

290 295 300

Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val

305 310 315 320

Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His

325 330 335

Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu

340 345 350

Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln

355 360 365

Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu

370 375 380

Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Ala

385 390 395 400

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

405 410 415

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

420 425 430

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

435 440 445

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

450 455 460

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

465 470 475 480

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

485 490 495

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

725 730 735

Gly Ser Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu

740 745 750

Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val

755 760 765

Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala

770 775 780

Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu

785 790 795 800

Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu

805 810 815

Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala

820 825 830

Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala

835 840 845

Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala

850 855 860

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu

865 870 875 880

Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu

885 890 895

Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile

900 905 910

Pro Ala Gly Leu Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly

915 920 925

Glu Gly Ser Thr Lys Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp

930 935 940

Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val

945 950 955 960

Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp

965 970 975

Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu

980 985 990

Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe

995 1000 1005

Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly

1010 1015 1020

Ser Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala

1025 1030 1035

Gly Ala Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser

1040 1045 1050

Ser Glu Ala Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu

1055 1060 1065

His Leu Ser Ala Gly Gln Arg Leu Gly Val His Leu His Thr Glu

1070 1075 1080

Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln Gly Ala Thr Val

1085 1090 1095

Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala Gly Leu Gly

1100 1105 1110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Glu Gly Pro Glu Leu

1115 1120 1125

Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met

1130 1135 1140

Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu Ile Asp Gly Pro

1145 1150 1155

Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val Ser Leu Thr

1160 1165 1170

Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val Val Ala

1175 1180 1185

Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg Arg

1190 1195 1200

Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His

1205 1210 1215

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu

1220 1225 1230

Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala

1235 1240 1245

Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg

1250 1255 1260

Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp

1265 1270 1275

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr

1280 1285 1290

Pro Glu Ile Pro Ala Gly Leu

1295 1300

<210> 178

<211> 3903

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 178

gagatcgtga tgacacaatc tccatctacg ctctccgcct cagtgggcga tagagtaatt 60

attacttgtc aagcctcaga gagcatttca tcatggctcg cctggtatca gcaaaagcct 120

gggaaggccc ccaaacttct catctatgaa gcatcaaagc tggcctctgg ggttccgtct 180

cgcttctccg ggtccggcag tggtgcagag tttacgttga ctatatcttc tttgcaacct 240

gacgatttcg caacatatta ttgccaggga tacttttatt ttatttcccg aacatatgtt 300

aactcttttg ggtgcgggac caaactcact gtgctggggt ctaccggtag tggttctaag 360

cctggttcag gcgaaggcag tacgaaaggg gaagtgcaac tggtcgaaag cggtggaggg 420

cttgttcaac ctggaggaag cctccgcttg tcctgcacgg ctagcggctt tacaataagt 480

acgaacgcca tgagctgggt ccggcaggct ccaggtaagt gtctcgaatg ggtggggggtc 540

ataacaggca gggacattac ctactacgcc agttgggcca agggtcgatt taccatttct 600

agagatacat ccaagaacac ggtgtacctc cagatgaatt ctcttagggc ggaagacaca 660

gcagtatact actgcgcgcg agatggcggg agcagtgcga tcacatccaa caacatctgg 720

ggtcagggca ctcttgtcac ggtgtcgact ggcggtggag ggtccggcgg tggtggatca 780

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 840

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 900

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 960

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 1020

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 1080

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 1140

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgct 1200

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 1260

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 1320

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 1380

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 1440

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 1500

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tgtaccctgc ccccatcccg ggatgagctg 1920

accaagaacc aggtcagcct gtcctgcgcc gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctcgtgagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atcccgagag 2220

ggccccgagc tgtctcctga tgacccagca ggcctcttgg acttgcggca gggtatgttc 2280

gctcaacttg tggctcagaa tgttctgctc attgatggac cactctcttg gtatagtgac 2340

cccggtctgg ccggggtgag tctgaccggc gggctctctt ataaagagga tactaaggaa 2400

ctggtcgtag caaaagcggg cgtttattac gttttttttc agctggagct caggcgcgtg 2460

gtggccggcg agggcagtgg ctctgtgtcc ctggccctgc acttacagcc cttgagaagc 2520

gctgcaggtg ctgccgcact ggctttaact gttgacctcc ctccggcctc ttctgaagct 2580

agaaacagcg ctttcggctt ccaagggcgc ctgctgcacc tgagcgcagg ccagcgctta 2640

ggtgtgcacc ttcatacaga ggccagggcc cgacacgctt ggcagctcac acagggtgcc 2700

acggttctcg gacttttccg cgttactccc gagatccccg ctggcctcgg aagtactggt 2760

tctgggtcta aacccggttc cggcgaaggt agtactaaag gacgagaagg gccagagtta 2820

agtccagatg accctgctgg gcttttggac ctgcggcagg gcatgttcgc tcaactggtg 2880

gctcagaacg tgctgctgat cgatggcccc ctgagttggt acagcgatcc cgggctggca 2940

ggcgtgtcac ttacaggggg cctctcttac aaggaagaca ccaaggagtt agtggtcgct 3000

aaggctggcg tgtattacgt gttcttccaa ctggagctga gaagggttgt ggcaggagag 3060

ggtagcggca gcgtgtcttt agcccttcac ttgcagcccc tgaggtctgc tgcaggtgca 3120

gccgctctcg cgctcaccgt ggatctcccc ccagcctcat ctgaagctag gaacagtgca 3180

tttggctttc agggacgctt gctgcacctc tccgctggac agaggctggg cgtgcacctt 3240

cacacagagg cccgtgccag gcatgcatgg cagctcactc agggggcaac agtgctgggt 3300

ctcttccgcg tgactcctga aataccagct ggacttggcg gtggaggcag cggcggagga 3360

ggatctcgtg aggggccaga actngtccccc gatgacccag ccggactgct cgatctcaga 3420

cagggcatgt tcgctcagct tgtagcccaa aatgtcctcc tgattgacgg ccctttgagc 3480

tggtatagtg atcccggctt ggccggggta tctctgaccg gaggcctctc ctacaaggaa 3540

gacaccaaag agctggtggt ggcaaaagcg ggggtgtatt atgtgttctt tcagctcgag 3600

ctgcggagag ttgtggccgg ggaagggtct gggagcgtat ctcttgcact tcacctgcag 3660

cccctgcgca gcgccgctgg agccgccgcc cttgctctta ctgtggatct gcctcctgct 3720

tcctcagaag cacgcaacag cgccttcggc tttcaaggac gtctcctgca cttgtccgca 3780

ggacagaggt tgggcgtcca tttacacact gaggcacggg cacggcacgc ttggcagctt 3840

acccagggag ccaccgtgct gggactcttt agagtgacac ccgagatccc cgctggcttg 3900

taa 3903

<210> 179

<211> 990

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 179

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Gly Ser Thr Gly Ser Gly

100 105 110

Ser Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Gln Val Thr Leu

115 120 125

Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln Thr Leu Arg Leu

130 135 140

Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val

145 150 155 160

Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Ala His

165 170 175

Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala Leu Lys Ser Arg

180 185 190

Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Tyr Leu Gln Met

195 200 205

Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Met

210 215 220

Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val

225 230 235 240

Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Leu

245 250 255

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr

260 265 270

Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr

275 280 285

Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys

290 295 300

Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln

305 310 315 320

Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His

325 330 335

Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser

340 345 350

Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu

355 360 365

Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn

370 375 380

Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser

385 390 395 400

Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala

405 410 415

Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val

420 425 430

Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser

435 440 445

Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr

450 455 460

Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys

465 470 475 480

Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn

485 490 495

Arg Gly Glu Cys Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro

500 505 510

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

515 520 525

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

530 535 540

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

545 550 555 560

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

565 570 575

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

580 585 590

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

595 600 605

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

610 615 620

Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu

625 630 635 640

Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro

645 650 655

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

660 665 670

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

675 680 685

Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

690 695 700

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

705 710 715 720

Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly

725 730 735

Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro

740 745 750

Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser

755 760 765

Ser Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu

770 775 780

Glu Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp

785 790 795 800

Ala Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys

805 810 815

Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala

820 825 830

Val Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp

835 840 845

Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly

850 855 860

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

865 870 875 880

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

885 890 895

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His

900 905 910

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

915 920 925

Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

930 935 940

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

945 950 955 960

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn

965 970 975

Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

980 985 990

<210> 180

<211> 2973

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 180

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaattgg agataaaggg aagtactggt tctgggtcta aacccggttc cggcgaaggt 360

agtactaaag gacaggtcac attgaaggaa tctggccccg gccttgttca gccaggacag 420

acccttaggc tcacctgtgc cttcagtggt ttttctctta gcactagcgg tatgggggtc 480

ggctggattc ggcagcctcc cggcaaaggt cttgagtggt tggctcacat ttggtgggac 540

gacgacaaac ggtataatcc tgccttgaaa agtcggctga ccattagtaa ggatacctca 600

aaaaatcaag tgtacttgca aatgaatagc cttgacgccg aggatacggc tgtatattat 660

tgcgcgcgga tggaactctg gtcttactac tttgattatt gggggcaggg gactctcgtc 720

acggtgtcga ctggcggtgg agggtccggc ggtggtggat cattcctaaa ctcattattc 780

aaccaagaag ttcaaattcc cttgaccgaa agttactgtg gcccatgtcc taaaaactgg 840

atatgttaca aaaataactg ctaccaattt tttgatgaga gtaaaaactg gtatgagagc 900

caggcttctt gtatgtctca aaatgccagc cttctgaaag tatacagcaa agaggaccag 960

gatttactta aactggtgaa gtcatatcat tggatgggac tagtacacat tccaacaaat 1020

ggatcttggc agtgggaaga tggctccat ctctcaccca acctactaac aataattgaa 1080

atgcagaagg gagactgtgc actctatgcc tcgagcttta aaggctatat agaaaactgt 1140

tcaactccaa atacgtacat ctgcatgcaa aggactgtgc gtacggtggc tgcaccatct 1200

gtcttcatct tcccgccatc tgatgagcag ttgaaatctg gaactgcctc tgttgtgtgc 1260

ctgctgaata acttctatcc cagagaggcc aaagtacagt ggaaggtgga taacgccctc 1320

caatcgggta actcccagga gagtgtcaca gagcaggaca gcaaggacag cacctacagc 1380

ctcagcagca ccctgacgct gagcaaagca gactacgaga aacacaaagt ctacgcctgc 1440

gaagtcaccc atcagggcct gagctcgccc gtcacaaaga gcttcaacag gggagagtgt 1500

ggaggcgaca aaactcacac atgcccaccg tgcccagcac ctgaagccgc ggggggaccg 1560

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 1620

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 1680

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacgccagc 1740

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 1800

tacaagtgcg cggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1860

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg 1920

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc 1980

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 2040

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 2100

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 2160

aagagcctct ccctgtctcc gggtggcggt ggagggtccg gcggtggtgg atccgaggtg 2220

cagctgttgg agtctggggg aggcttggta cagcctgggg ggtccctgag actctcctgt 2280

gcagcctctg gattctcctt cagtagcggg tacgacatgt gctgggtccg ccaggctcca 2340

gggaagtgcc tggagtggat cgcatgcatt gctgctggta gtgctggtat cacttacgac 2400

gcgaactggg cgaaaggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 2460

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gagatcggcg 2520

ttttcgttcg actacgccat ggacctctgg ggccagggaa ccctggtcac cgtctcgtct 2580

ggtggaggcg gttcaggcgg aggtggaagt ggtggtggcg gctctggagg cggcggatct 2640

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 2700

atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 2760

gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 2820

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 2880

gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 2940

ttcggctgcg ggaccaaggt ggagatcaaa tag 2973

<210> 181

<211> 449

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 181

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu

1 5 10 15

Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly

20 25 30

Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu

35 40 45

Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser

50 55 60

Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe

65 70 75 80

Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr

85 90 95

Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly

100 105 110

Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe

115 120 125

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu

130 135 140

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp

145 150 155 160

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu

165 170 175

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser

180 185 190

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro

195 200 205

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys

210 215 220

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro

225 230 235 240

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser

245 250 255

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp

260 265 270

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn

275 280 285

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val

290 295 300

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu

305 310 315 320

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys

325 330 335

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr

340 345 350

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr

355 360 365

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu

370 375 380

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu

385 390 395 400

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys

405 410 415

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu

420 425 430

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly

435 440 445

Lys

<210> 182

<211> 1350

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 182

caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60

acctgcactg tctctggtgg ctccgtcagc agtggtgatt actactggac ctggatccgg 120

cagtccccag ggaagggact ggagtggatt ggacacatct attacagtgg gaacaccaat 180

tataacccct ccctcaagag ccgactcacc atatcaattg acacgtccaa gactcagttc 240

tccctgaagc tgagttctgt gaccgctgcg gacacggcca tttattactg tgtgcgagat 300

cgagtgactg gtgcttttga tatctggggc caagggacaa tggtcaccgt ctcgagcgct 360

agcaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac 600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa 660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggagaggagatg 1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200

gactccgacg gctccttctt cctctatagc aagctcaccg tggacaagag caggtggcag 1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320

aagagcctct ccctgtctcc gggtaaatga 1350

<210> 183

<211> 214

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 183

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala

100 105 110

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly

115 120 125

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala

130 135 140

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln

145 150 155 160

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser

165 170 175

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr

180 185 190

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser

195 200 205

Phe Asn Arg Gly Glu Cys

210

<210> 184

<211> 645

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 184

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggcgga 300

gggaccaagg tggaaattaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca 360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat 420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag 480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg 540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc 600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag 645

<210> 185

<211> 485

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 185

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

1 5 10 15

Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

20 25 30

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

35 40 45

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

50 55 60

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

65 70 75 80

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

85 90 95

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala

100 105 110

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

115 120 125

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

130 135 140

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser

145 150 155 160

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

165 170 175

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr

180 185 190

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

195 200 205

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

210 215 220

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly

225 230 235 240

Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly

245 250 255

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser

260 265 270

Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

275 280 285

Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser

290 295 300

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu

305 310 315 320

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

325 330 335

Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly

340 345 350

Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly

355 360 365

Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala Ser Val

370 375 380

Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser

385 390 395 400

Ser Asp Val Gly Gly Tyr Asn Phe Val Ser Trp Tyr Gln Gln His Pro

405 410 415

Gly Lys Ala Pro Lys Leu Met Ile Tyr Asp Val Ser Asp Arg Pro Ser

420 425 430

Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser

435 440 445

Leu Ile Ile Ser Gly Leu Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys

450 455 460

Ser Ser Tyr Gly Ser Ser Ser Thr His Val Ile Phe Gly Gly Gly Thr

465 470 475 480

Lys Val Thr Val Leu

485

<210> 186

<211> 1458

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 186

gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 60

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggagggagcag 240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660

tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720

tcccaggtgc agctgcagga gtcgggggga ggcctggtca agcctggagg gtccctgaga 780

ctctcctgtg cagcctctgg attcaccttt agtagttatt ggatgagctg ggtccgccag 840

gctccaggga aggggctgga gtgggtggcc aacataaacc gcgatggaag tgcgagttac 900

tatgtggact ctgtgaaggg ccgattcacc atctccagag acgacgccaa gaactcactg 960

tatctgcaaa tgaacagcct gagagctgag gacacggctg tgtattactg tgcgagagat 1020

cgtggggtgg gctacttcga tctctggggc cgtggcaccc tggtcaccgt ctcgagcggt 1080

ggaggcggtt caggcggagg tggttccggc ggtggcggct cccagtctgc cctgactcag 1140

cctgcctccg tgtctgggtc tcctggacag tcgatcacca tctcctgcac tggaaccagc 1200

agtgacgttg gtggttataa ctttgtctcc tggtaccaac aacacccagg caaagccccc 1260

aaactcatga tctatgatgt cagtgatcgg ccctcagggg tgtctgatcg cttctccggc 1320

tccaagtctg gcaacacggc ctccctgatc atctctggcc tccaggctga cgacgaggct 1380

gattattact gcagctcata tgggagcagc agcactcatg tgattttcgg cggagggacc 1440

aaggtgaccg tcctataa 1458

<210> 187

<211> 449

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val

115 120 125

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala

130 135 140

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser

145 150 155 160

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val

165 170 175

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro

180 185 190

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys

195 200 205

Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp

210 215 220

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala

225 230 235 240

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile

245 250 255

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu

260 265 270

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His

275 280 285

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg

290 295 300

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys

305 310 315 320

Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu

325 330 335

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr

340 345 350

Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu

355 360 365

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp

370 375 380

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val

385 390 395 400

Leu Asp Ser Asp Gly Ser Phe Leu Leu Tyr Ser Lys Leu Thr Val Asp

405 410 415

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His

420 425 430

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro

435 440 445

Gly

<210> 188

<211> 1350

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 188

gaagtccaat tggtagaaag tggcggtggt ctggtgcaac ctggtggatc tcttcgcctc 60

tcatgcacgg ctagtggctt tactatttca actaatgcga tgagctgggt tcgccaggcc 120

cccggcaaag gacttgagtg ggtcggcgtc atcaccggca gggacattac atactatgcg 180

agttgggcaa agggcaggtt cacgattagc cgcgatactt caaagaatac cgtttacctt 240

caaatgaata gcttgcgcgc ggaagacaca gctgtgtatt actgcgcgcg ggatggaggt 300

agttccgcca taacttccaa caacatatgg ggacaaggca cgctggttac tgtgtcgtca 360

gctagcacca agggcccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 420

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 480

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 540

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 600

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaagc cgcgggggca 720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 960

gagtacaagt gcgcggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag 1080

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 1200

ctggactccg acggctcctt cctgctctat agcaagctca ccgtggacaa gagcaggtgg 1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 1320

cagaagagcc tctccctgtc tccggggttga 1350

<210> 189

<211> 219

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 189

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu

100 105 110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

115 120 125

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

130 135 140

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

145 150 155 160

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

165 170 175

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

180 185 190

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

195 200 205

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys

210 215

<210> 190

<211> 660

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 190

gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60

atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120

ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180

aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240

gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300

aactccttcg gccaaggaac aaagttgact gttcttcgta cggtggctgc accatctgtc 360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag 660

<210> 191

<211> 487

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 191

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

1 5 10 15

Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

20 25 30

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

35 40 45

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

50 55 60

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

65 70 75 80

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

85 90 95

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala

100 105 110

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

115 120 125

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

130 135 140

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser

145 150 155 160

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

165 170 175

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr

180 185 190

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

195 200 205

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

210 215 220

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly

225 230 235 240

Ser Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

245 250 255

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr

260 265 270

His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile

275 280 285

Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg

290 295 300

Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu

305 310 315 320

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

325 330 335

Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val

340 345 350

Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

355 360 365

Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Val Met Thr Gln Ser Pro

370 375 380

Ser Ser Val Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln

385 390 395 400

Ala Ser Gln Asn Ile Arg Thr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro

405 410 415

Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ala Asn Leu Ala Ser

420 425 430

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

435 440 445

Leu Thr Ile Ser Asp Leu Glu Pro Gly Asp Ala Ala Thr Tyr Tyr Cys

450 455 460

Gln Ser Thr Tyr Leu Gly Thr Asp Tyr Val Gly Gly Ala Phe Gly Gly

465 470 475 480

Gly Thr Lys Val Glu Ile Lys

485

<210> 192

<211> 1464

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 192

gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 60

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggagggagcag 240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300

ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660

tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720

tcccggtcgc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 780

tcctgtactg cctctggatt caccatcagt agctaccaca tgcagtgggt ccgccaggct 840

ccagggaagg ggctggagta catcggaacc attagtagtg gtggtaatgt atactacgcg 900

agctccgcga gaggcagatt caccatctcc agaccctcgt ccaagaacac ggtggatctt 960

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agactctggt 1020

tatagtgatc ctatgtgggg ccagggaacc ctggtcaccg tctcttcagg cggtggcggt 1080

agtgggggag gcggttctgg cggcggaggg tccggcggtg gaggatcaga cgttgtgatg 1140

acccagtctc catcttccgt gtctgcatct gtaggagaca gagtcaccat cacctgtcag 1200

gccagtcaga acattaggac ttacttatcc tggtatcagc agaaaccagg gaaagcccct 1260

aagctcctga tctatgctgc agccaatctg gcatctgggg tcccatcaag gttcagcggc 1320

agtggatctg ggacagattt cactctcacc atcagcgacc tggagcctgg cgatgctgca 1380

acttactatt gtcagtctac ctatcttggt actgattatg ttggcggtgc tttcggcgga 1440

gggaccaagg tggagatcaa atga 1464

<210> 193

<211> 493

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 193

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala

1 5 10 15

Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

20 25 30

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

35 40 45

Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val

50 55 60

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

65 70 75 80

Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

85 90 95

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala

100 105 110

Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

115 120 125

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr

130 135 140

Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser

145 150 155 160

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

165 170 175

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr

180 185 190

Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe

195 200 205

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

210 215 220

Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly

225 230 235 240

Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

245 250 255

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser

260 265 270

Gly Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu

275 280 285

Trp Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala

290 295 300

Asn Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn

305 310 315 320

Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

325 330 335

Tyr Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu

340 345 350

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser

355 360 365

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp

370 375 380

Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly Asp

385 390 395 400

Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His Leu

405 410 415

Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr

420 425 430

Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

435 440 445

Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp

450 455 460

Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn Val

465 470 475 480

Asp Asn Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

485 490

<210> 194

<211> 1482

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 194

gagcccaaat cttccgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 60

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 120

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 180

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggagggagcag 240

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 300

ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 360

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 420

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 480

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 540

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 600

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 660

tacacgcaga agagcctctc cctgtctccg ggtggcggtg gagggtccgg cggtggtgga 720

tccgaggtgc agctgttgga gtctggggga ggcttggtac agcctggggg gtccctgaga 780

ctctcctgtg cagcctctgg attctccttc agtagcgggt acgacatgtg ctgggtccgc 840

caggctccag ggaaggggct ggagtggatc gcatgcattg ctgctggtag tgctggtatc 900

acttacgacg cgaactgggc gaaaggccgg ttcaccatct cccagagacaa ttccaagaac 960

acgctgtatc tgcaaatgaa cagcctgaga gccgaggaca cggccgtata ttactgtgcg 1020

agatcggcgt tttcgttcga ctacgccatg gacctctggg gccagggaac cctggtcacc 1080

gtctcgagcg gtggaggcgg atctggcgga ggtggttccg gcggtggcgg ctccggtgga 1140

ggcggctctg acatccagat gacccagtct ccttccaccc tgtctgcatc tgtaggagac 1200

agagtcacca tcacttgcca ggccagtcag agcattagtt cccacttaaa ctggtatcag 1260

cagaaaccag ggaaagcccc taagctcctg atctataagg catccactct ggcatctggg 1320

gtcccatcaa ggttcagcgg cagtggatct gggacagaat ttactctcac catcagcagc 1380

ctgcagcctg atgattttgc aacttattac tgccaacagg gttatagttg gggtaatgtt 1440

gataatgttt tcggcggagg gaccaaggtg gagatcaaat aa 1482

<210> 195

<211> 713

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 195

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile

85 90 95

Ile Tyr Gly Ala Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln

130 135 140

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe

145 150 155 160

Ser Gly Thr Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Cys

165 170 175

Leu Glu Trp Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr

180 185 190

Ala Thr Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys

195 200 205

Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala

210 215 220

Val Tyr Tyr Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu

225 230 235 240

Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr Gly Gly Gly

245 250 255

Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly

260 265 270

Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser

275 280 285

Gly Phe Thr Ile Ser Thr Asn Ala Met Ser Trp Val Arg Gln Ala Pro

290 295 300

Gly Lys Gly Leu Glu Trp Ile Gly Val Ile Thr Gly Arg Asp Ile Thr

305 310 315 320

Tyr Tyr Ala Ser Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn

325 330 335

Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp

340 345 350

Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr

355 360 365

Ser Asn Asn Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala

370 375 380

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser

385 390 395 400

Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe

405 410 415

Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly

420 425 430

Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu

435 440 445

Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr

450 455 460

Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg

465 470 475 480

Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro

485 490 495

Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys

500 505 510

Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val

515 520 525

Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr

530 535 540

Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu

545 550 555 560

Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His

565 570 575

Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys

580 585 590

Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln

595 600 605

Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu

610 615 620

Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro

625 630 635 640

Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn

645 650 655

Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu

660 665 670

Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val

675 680 685

Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln

690 695 700

Lys Ser Leu Ser Leu Ser Pro Gly Lys

705 710

<210> 196

<211> 2139

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 196

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300

gctttcggct gtgggaccaa ggtggagatc aaaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcagaggtgc agctggtgga gtctggggga 420

ggcttggtcc agcctggggg gtccctgaga ctctcctgtg cagcctctgg attctccttc 480

agtggcaccc agtacgtgtg ctgggtccgc caggctccag ggaagtgcct ggagtggatc 540

ggatgcattt atgtggatgt ggctaacact tactacgcga cctccgtgaa gggcagattc 600

accatctcca gagacaattc caagaacacg ctgtatcttc aaatgaacag cctgagagcc 660

gaggacacgg ctgtgtatta ctgtgcgagt catgatactg tttgtgctgg ttgtggtttg 720

gacttgtggg gccagggaac cctggtcacc gtgtcgacag gcggtggagg gtccggcggt 780

ggtggatcag aggtgcagct ggtggagtct gggggaggct tggtccagcc tggggggtcc 840

ctgagactct cctgtgcagc ctctggattc accatcagta ccaatgcaat gagctgggtc 900

cgccaggctc cagggaaggg gctggagtgg atcggagtca ttactggtcg tgatatcaca 960

tactacgcga gctgggcgaa aggcagattc accatctcca gagacaattc caagaacacg 1020

ctgtatcttc aaatgaacag cctgagagcc gaggacacgg ctgtgtatta ctgtgcgaga 1080

gacggtggtt cttctgctat tactagtaac aacatttggg gccagggaac cctggtcacc 1140

gtgtcctcag ctagcaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 1200

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg 1260

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 1320

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 1380

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga 1440

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagcc 1500

gcggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 1560

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 1620

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 1680

cagtacgcca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1740

aatggcaagg agtacaagtg cgcggtctcc aacaaagccc tcccagcccc catcgagaaa 1800

accatctcca aagccaaagg gcagccccga gaaccacagg tgtgtaccct gcccccatcc 1860

cgggatgagc tgaccaagaa ccaggtcagc ctgtcctgcg ccgtcaaagg cttctatccc 1920

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 1980

cctcccgtgc tggactccga cggctccttc ttcctcgtga gcaagctcac cgtggacaag 2040

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 2100

cactacacgc agaagagcct ctccctgtct ccgggtaaa 2139

<210> 197

<211> 704

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 197

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln

115 120 125

Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr

130 135 140

Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly Asp

145 150 155 160

Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu Trp

165 170 175

Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu

180 185 190

Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe Ser

195 200 205

Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr Cys

210 215 220

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr

225 230 235 240

Met Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

245 250 255

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

260 265 270

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

275 280 285

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

290 295 300

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

305 310 315 320

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

325 330 335

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

340 345 350

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

355 360 365

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

370 375 380

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

385 390 395 400

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

405 410 415

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

420 425 430

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

435 440 445

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

450 455 460

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

465 470 475 480

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

485 490 495

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

500 505 510

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

515 520 525

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

530 535 540

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val

545 550 555 560

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

565 570 575

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

580 585 590

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

595 600 605

Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

610 615 620

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

625 630 635 640

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

645 650 655

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

660 665 670

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

675 680 685

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

690 695 700

<210> 198

<211> 2112

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 198

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300

gggaccaagg tggaaattaa aggcggtggc ggtagtgggg gaggcggttc tggcggcgga 360

gggtccggcg gtggaggatc acaggtgcag ctgcaggagt cgggcccagg actggtgaag 420

ccttcggaga ccctgtccct cacctgcact gtctctggtg gctccgtcag cagtggtgat 480

tactactgga cctggatccg gcagtcccca gggaagtgcc tggagtggat tggacacatc 540

tattacagtg ggaacaccaa ttataacccc tccctcaaga gccgactcac catatcaatt 600

gacacgtcca agactcagtt ctccctgaag ctgagttctg tgaccgctgc ggacacggcc 660

atttattact gtgtgcgaga tcgagtgact ggtgcttttg atatctgggg ccaagggaca 720

atggtcaccg tgtcgacagg cggtggaggg tccggcggtg gtggatcaga cgtcgtgatg 780

acccagtctc cttccaccct gtctgcatct gtaggagaca gagtcaccat caattgccaa 840

gccagtgaga gcattagcag ttggttagcc tggtatcagc agaaaccagg gaaagcccct 900

aagctcctga tctatgaagc atccaaactg gcatctgggg tcccatcaag gttcagcggc 960

agtggatctg ggacagaatt cactctcacc atcagcagcc tgcagcctga tgattttgca 1020

acttattact gccaaggcta tttttatttt attagtcgta cttatgtaaa ttctttcggc 1080

ggagggacca aggtggagat caaacgtacg gtggctgcac catctgtctt catcttcccg 1140

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc 1200

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc 1260

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg 1320

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag 1380

ggcctgagct cgcccgtcac aaagagcttc aacagggag agtgtggagg cgacaaaact 1440

cacacatgcc caccgtgccc agcacctgaa gccgcggggg gaccgtcagt cttcctcttc 1500

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 1560

gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 1620

gtgcataatg ccaagacaaa gccgcgggag gagcagtacg ccagcacgta ccgtgtggtc 1680

agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcgcggtc 1740

tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1800

cgagaaccac aggtgtacac cctgccccca tgtcgggatg agctgaccaa gaaccaggtc 1860

agcctgtggt gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtggggagagc 1920

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1980

ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 2040

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 2100

tctccgggta aa 2112

<210> 199

<211> 707

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 199

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala

20 25 30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro

85 90 95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser

100 105 110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu

115 120 125

Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser

130 135 140

Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr

145 150 155 160

Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala

165 170 175

Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys

180 185 190

Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu

195 200 205

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser

210 215 220

Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly

225 230 235 240

Thr Leu Val Thr Val Ser Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly

245 250 255

Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly

260 265 270

Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr

275 280 285

Asn Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

290 295 300

Ile Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala

305 310 315 320

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr

325 330 335

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

340 345 350

Ala Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly

355 360 365

Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser

370 375 380

Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala

385 390 395 400

Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val

405 410 415

Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala

420 425 430

Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val

435 440 445

Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His

450 455 460

Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys

465 470 475 480

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly

485 490 495

Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met

500 505 510

Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His

515 520 525

Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val

530 535 540

His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr

545 550 555 560

Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly

565 570 575

Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile

580 585 590

Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val

595 600 605

Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser

610 615 620

Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu

625 630 635 640

Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro

645 650 655

Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr Val

660 665 670

Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met

675 680 685

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser

690 695 700

Pro Gly Lys

705

<210> 200

<211> 2121

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 200

gacatccaaa tgacgcagtc tccctccagt ttgagtgcaa gtgtgggaga cagagttacg 60

atcacatgta gggcaagtca ggacgtcaat acagccgtcg catggtacca gcagaagcct 120

ggaaaggccc cgaaacttct gatttactct gcaagtttcc tctacagtgg tgttcctagt 180

cgcttcagtg ggtctcggtc aggcaccgat tttaccctga caattagcag cttgcaaccg 240

gaagatttg cgacctatta ttgccagcaa cattatacca cccctcccac atttggacaa 300

ggcacgaagg tagagattaa aggcggtgga gggagcggtg gaggcggttc cggtggaggt 360

ggttctggtg gaggtggcag tgaagtacag cttgttgaga gtggtggtgg acttgtccaa 420

ccagggggaa gtctgcggct gtcatgcgca gcctctggct tcaacattaa ggacacctac 480

attcactggg ttcggcaagc gccggggaag gggctggaat gggtcgccag gatataccct 540

accaacgggt acaccaggta tgcagatagc gttaagggta gattcactat ttcagctgac 600

actagcaaga acaccgcgta tctccagatg aactcccttc gcgccgagga tacggctgtg 660

tactactgct ctaggtgggg aggagatggg ttttacgcaa tggattactg gggacaggga 720

acactcgtta cggtgtcgac aggcggtgga gggtccggcg gtggtggatc agaggtgcag 780

ctggtggagt ctgggggagg cttggtccag cctggggggt ccctgagact ctcctgtgca 840

gcctctggat tcaccatcag taccaatgca atgagctggg tccgccaggc tccagggaag 900

gggctggagt ggatcggagt cattactggt cgtgatatca catactacgc gagctgggcg 960

aaaggcagat tcaccatctc cagagacaat tccaagaaca cgctgtatct tcaaatgaac 1020

agcctgagag ccgaggacac ggctgtgtat tactgtgcga gagacggtgg ttcttctgct 1080

attactagta acaacatttg gggccaggga accctggtca ccgtgtcctc agctagcacc 1140

aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg 1200

gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca 1260

ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac 1320

tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc 1380

aacgtgaatc acaagcccag caacaccaag gtggacaaga gagttgagcc caaatcttgt 1440

gacaaaactc acacatgccc accgtgccca gcacctgaag ccgcgggggg accgtcagtc 1500

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca 1560

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac 1620

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacgc cagcacgtac 1680

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag 1740

tgcgcggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa 1800

gggcagcccc gagaaccaca ggtgtgtacc ctgcccccat cccgggatga gctgaccaag 1860

aaccaggtca gcctgtcctg cgccgtcaaa ggcttctatc ccagcgacat cgccgtggag 1920

tggggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc 1980

gacggctcct tcttcctcgt gagcaagctc accgtggaca agagcaggtg gcagcagggg 2040

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc 2100

ctctccctgt ctccggggtaa a 2121

<210> 201

<211> 448

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 201

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu

115 120 125

Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe

130 135 140

Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln

145 150 155 160

Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser

165 170 175

Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu

180 185 190

Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser

195 200 205

Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Asp Lys Thr

210 215 220

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser

225 230 235 240

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg

245 250 255

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro

260 265 270

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala

275 280 285

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val

290 295 300

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr

305 310 315 320

Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr

325 330 335

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu

340 345 350

Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys

355 360 365

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser

370 375 380

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp

385 390 395 400

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser

405 410 415

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala

420 425 430

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys

435 440 445

<210> 202

<211> 1344

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 202

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gcggagggac caaggtggag atcaaacgta cggtggctgc accatctgtc 360

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg 420

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa 480

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc 540

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgtgga 660

ggcgacaaaa ctcacacatg cccaccgtgc ccagcacctg aagccgcggg gggaccgtca 720

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 780

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 840

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta cgccagcacg 900

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caagggagtac 960

aagtgcgcgg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1020

aaagggcagc cccgagaacc acaggtgtac accctgcccc catgtcggga tgagctgacc 1080

aagaaccagg tcagcctgtg gtgcctggtc aaaggcttct atcccagcga catcgccgtg 1140

gagtggggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1200

tccgacggct ccttcttcct ctatagcaag ctcaccgtgg acaagagcag gtggcagcag 1260

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1320

agcctctccc tgtctccggg taaa 1344

<210> 203

<211> 119

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 203

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Glu

1 5 10 15

Thr Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr

20 25 30

Gly Val His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu

35 40 45

Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr

50 55 60

Ser Arg Phe Thr Ile Thr Lys Asp Asn Ser Lys Asn Gln Val Tyr Phe

65 70 75 80

Lys Leu Arg Ser Val Arg Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala

85 90 95

Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly

100 105 110

Thr Leu Val Thr Val Ser Ser

115

<210> 204

<211> 357

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 204

caagtacagt tgcagcaatc cggtcccggt ctcgtcaaac cgagtgagac gcttagtata 60

acgtgtactg tttcaggctt tagccttacg aactatggag ttcactggat tcggcaggca 120

cccggcaaag gtttggaatg gctgggtgtt atttggtcag gtggaaatac agactataac 180

acccccttta caagtcggtt cacaattacg aaagataatt ccaaaaatca agtttatttc 240

aagttgagat ccgtccgcgc ggacgacact gcgatctact attgtgcgag ggcactgacc 300

tactacgatt acgaatttgc gtattggggg caagggactc ttgtaacagt ctcgagc 357

<210> 205

<211> 107

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 205

Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Val Ser Pro Gly

1 5 10 15

Glu Arg Ala Thr Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn

20 25 30

Ile His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Arg Leu Leu Ile

35 40 45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Asp Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Val Gln Ser

65 70 75 80

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr

85 90 95

Thr Phe Gly Pro Gly Thr Lys Leu Thr Val Leu

100 105

<210> 206

<211> 321

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 206

gaaatcgtcc ttacacaatc tcctagcaca ctgagtgtga gccccggcga acgcgcgact 60

ttctcttgca gggcaagtca atccataggg actaatatac attggtatca acaaaagcca 120

ggtaaaccac ccaggctttt gattaagtat gcaagtgagt ctatttccgg tatccctgac 180

cgcttctctg gatcaggcag tggcacagag ttcacactca ccatatctag tgtgcaatca 240

gaggacttcg ccgtgtatta ctgccaacag aataataact ggccgactac cttcggaccc 300

ggtacaaagc tgaccgtttt a 321

<210> 207

<211> 119

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 207

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu

1 5 10 15

Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly

20 25 30

Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu

35 40 45

Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser

50 55 60

Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe

65 70 75 80

Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr

85 90 95

Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly

100 105 110

Thr Met Val Thr Val Ser Ser

115

<210> 208

<211> 357

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 208

caagtgcaac tccaggagag tgggccggga ttggttaaac cgagcgagac cctgagtctc 60

acgtgtacag tttcaggcgg gagcgtgagc tcaggcgact attactggac atggataaga 120

cagagtcctg gaaagggcct ggagtggatc ggtcatattt attattcagg gaacactaac 180

tataatccat ctttgaaatc ccgattgaca atctctatcg ataccagtaa aacccagttt 240

agcctcaagc tgtccagcgt tactgctgca gacacagcca tatactattg cgtacgcgat 300

cgcgtgactg gagccttcga catatggggg cagggaacga tggtaacagt ctcgagc 357

<210> 209

<211> 107

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105

<210> 210

<211> 321

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 210

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggcgga 300

gggaccaagg tggaaattaa a 321

<210> 211

<211> 119

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 211

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu

1 5 10 15

Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly

20 25 30

Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Cys Leu Glu

35 40 45

Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser

50 55 60

Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe

65 70 75 80

Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr

85 90 95

Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly

100 105 110

Thr Met Val Thr Val Ser Thr

115

<210> 212

<211> 357

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 212

caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60

acctgcactg tctctggtgg ctccgtcagc agtggtgatt actactggac ctggatccgg 120

cagtccccag ggaagtgcct ggagtggatt ggacacatct attacagtgg gaacaccaat 180

tataacccct ccctcaagag ccgactcacc atatcaattg acacgtccaa gactcagttc 240

tccctgaagc tgagttctgt gaccgctgcg gacacggcca tttattactg tgtgcgagat 300

cgagtgactg gtgcttttga tatctggggc caagggacaa tggtcaccgt gtcgaca 357

<210> 213

<211> 107

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 213

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu

85 90 95

Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

100 105

<210> 214

<211> 321

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 214

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggcgagtca ggacatcagc aactatttaa attggtatca gcagaaacca 120

gggaaagccc ctaaactcct gatctacgat gcatccaatt tggaaacagg ggtcccatca 180

aggttcagtg gaagtggatc tgggacagat tttactttca ccatcagcag cctgcagcct 240

gaagatattg caacatattt ctgtcaacac tttgatcatc tcccgctcgc tttcggctgt 300

gggaccaagg tggaaattaa a 321

<210> 215

<211> 120

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 215

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Gly Gln

1 5 10 15

Thr Leu Ser Leu Thr Cys Ala Phe Ser Gly Phe Ser Leu Ser Thr Ser

20 25 30

Gly Met Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu

35 40 45

Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ala

50 55 60

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val

65 70 75 80

Tyr Leu Gln Met Asn Ser Leu Asp Ala Glu Asp Thr Ala Val Tyr Tyr

85 90 95

Cys Ala Arg Met Glu Leu Trp Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 216

<211> 360

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 216

caggtcacat tgaaggaatc tggccccggc cttgttcagc caggacagac ccttagcctc 60

acctgtgcct tcagtggttt ttctcttagc actagcggta tgggggtcgg ctggattcgg 120

cagcctcccg gcaaaggtct tgagtggttg gctcacattt ggtgggacga cgacaaacgg 180

tataatcctg ccttgaaaag tcggctgacc attagtaagg atacctcaaa aaatcaagtg 240

tacttgcaaa tgaatagcct tgacgccgag gatacggctg tatattattg cgcgcggatg 300

gaactctggt cttactactt tgattattgg gggcagggga ctctcgtcac ggtctcgagc 360

<210> 217

<211> 106

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 217

Glu Asn Val Leu Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met

20 25 30

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Trp Ile Tyr

35 40 45

Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Asn Asp His Thr Leu Thr Ile Ser Ser Met Glu Pro Glu

65 70 75 80

Asp Phe Ala Thr Tyr Tyr Cys Phe Gln Gly Ser Val Tyr Pro Phe Thr

85 90 95

Phe Gly Gln Gly Thr Lys Val Thr Val Leu

100 105

<210> 218

<211> 318

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 218

gaaaatgtat tgacacagag ccccgcctcc ctcagtgcct cacctgggga aagggtaact 60

atcacttgct ctgcatcaag cagcgtctca tacatgcatt ggtatcaaca aaagcctgga 120

caggccccca agctctggat atacgatacg agcaagctgg cttccggcgt acctagccgc 180

ttcagtggtt ccggctcagg caacgatcac acccttacga tttccagtat ggaacccgaa 240

gattttgcaa cttattattg tttccagggg agcgtgtacc cattcacttt cgggcagggg 300

acaaaagtga ccgtccta 318

<210> 219

<211> 120

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 219

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 220

<211> 360

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 220

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60

tcctgtgcag cctctggatt caccatcagt accaatgcaa tgagctgggt ccgccaggct 120

ccagggaagg ggctggagtg gatcggagtc attactggtc gtgatatcac atactacgcg 180

agctgggcga aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacggtggt 300

tcttctgcta ttactagtaa caacatttgg ggccagggaa ccctggtcac cgtgtcctca 360

<210> 221

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 221

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 222

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 222

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gcggagggac caaggtggag atcaaa 336

<210> 223

<211> 120

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Ile

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 224

<211> 360

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 224

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60

tcctgtgcag cctctggatt caccatcagt accaatgcaa tgagctgggt ccgccaggct 120

ccagggaagt gtctggagtg gatcggagtc attactggtc gtgatatcac atactacgcg 180

agctgggcga aaggcagatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240

caaatgaaca gcctgagagc cgaggacacg gctgtgtatt actgtgcgag agacggtggt 300

tcttctgcta ttactagtaa caacatttgg ggccagggaa ccctggtcac cgtgtcctca 360

<210> 225

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 225

Asp Val Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 226

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 226

gacgtcgtga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcaattgcc aagccagtga gagcattagc agttggttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgaa gcatccaaac tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaaggc tatttttatt ttattagtcg tacttatgta 300

aattctttcg gctgtgggac caaggtggag atcaaa 336

<210> 227

<211> 113

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 227

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser

<210> 228

<211> 339

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 228

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatcc 339

<210> 229

<211> 110

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 229

Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Thr Arg Val

65 70 75 80

Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys

100 105 110

<210> 230

<211> 330

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 230

gatcctcaat tgacccagtc ccctagtagc ctttctgcaa ccgtgggcca gagggtaaca 60

atcaattgcc agtcaagcca gtccgtagcg aagaataata atttggcatg gttccaacaa 120

aaaccgggta aacctcctaa actccttatc tactcagctt caacccttgc cgcgggtgtg 180

cccagccggt tctcaggctc aggttccggg actcaattta cacttaccat cactcgcgtc 240

caaagtgagg attttgcaac ctactattgt tctgcacggg attccgggaa catacagtcc 300

tttggggggtg gaactcgggt ggagataaaa 330

<210> 231

<211> 120

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 231

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn

20 25 30

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

35 40 45

Gly Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 232

<211> 360

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 232

gaagtccaat tggtagaaag tggcggtggt ctggtgcaac ctggtggatc tcttcgcctc 60

tcatgcgccg ctagtggctt tactatttca actaatgcga tgagctgggt tcgccaggcc 120

cccggcaaag gacttgagtg ggtcggcgtc atcaccggca gggacattac atactatgcg 180

agttgggcaa agggcaggtt cacgattagc cgcgatactt caaagaatac cgtttacctt 240

caaatgaata gcttgagggc ggaagacaca gctgtgtatt actgcgcgag ggatggaggt 300

agttccgcca taacttccaa caacatatgg ggacaaggca cgctggttac tgtctcgagt 360

<210> 233

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 233

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gln Gly Thr Lys Leu Thr Val Leu

100 105 110

<210> 234

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 234

gaaatcgtta tgacgcagag tccctccacg ctctccgcta gtgtcgggga tcgcgtcatt 60

atcacatgcc aggcctccga gtcaatcagc agctggcttg catggtatca acagaagccg 120

ggaaaagctc ctaaattgct gatctatgaa gcgtcaaaat tggcgtctgg tgtcccatct 180

aggttctccg gctctgggtc tggtgcggaa tttactttga caatctccag tcttcaacca 240

gacgatttcg ctacctacta ctgccaaggg tatttctatt ttataagccg gacatatgta 300

aactccttcg gccaaggaac aaagttgact gttctt 336

<210> 235

<211> 118

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 235

Gln Gln Leu Leu Glu Ser Gly Gly Arg Leu Ile Lys Pro Gly Ala Thr

1 5 10 15

Leu Arg Leu Thr Cys Lys Thr Ser Gly Phe Thr Ile Ser Thr Asn Ala

20 25 30

Met Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly

35 40 45

Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly

50 55 60

Arg Phe Thr Ile Ser Lys Thr Ser Ile Asn Thr Val Phe Leu Gln Met

65 70 75 80

Arg Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp

85 90 95

Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Arg Gly Thr

100 105 110

Leu Val Thr Val Ser Ser

115

<210> 236

<211> 354

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 236

cagcagctgc tggaaagcgg cggccgcctg attaaaccgg gcgcgaccct gcgcctgacc 60

tgcaaaacca gcggctttac cattagcacc aacgcgatga gctgggtgcg ccagccgccg 120

ggcaaaggcc tggaatggat tggcgtgatt accggccgcg atattaccta ttatgcgagc 180

tgggcgaaag gccgctttac cattagcaaa accagcatta acaccgtgtt tctgcagatg 240

cgcagcctgc gcgcggaaga taccgcggtg tattattgcg cgcgcgatgg cggcagcagc 300

gcgattacca gcaacaacat ttggggccgc ggcaccctgg tgaccgtgag cagc 354

<210> 237

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 237

Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Thr Val Gly

1 5 10 15

Gln Arg Val Thr Ile Asn Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Arg Val Glu Ile Lys

100 105 110

<210> 238

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 238

gatgtgcaga tgacccagag cccgagcacc ctgagcgcga ccgtgggcca gcgcgtgacc 60

attaactgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120

ggccagccgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180

cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctgcagagc 240

gatgattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300

aacagctttg gcggcggcac ccgcgtggaa attaaa 336

<210> 239

<211> 118

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 239

Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser

1 5 10 15

Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Thr Asn Ala

20 25 30

Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly

35 40 45

Val Ile Thr Gly Arg Asp Ile Thr Tyr Tyr Ala Ser Trp Ala Lys Gly

50 55 60

Arg Phe Thr Ile Ser Lys Thr Ser Lys Asn Thr Val Tyr Leu Gln Met

65 70 75 80

Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp

85 90 95

Gly Gly Ser Ser Ala Ile Thr Ser Asn Asn Ile Trp Gly Gln Gly Thr

100 105 110

Leu Val Thr Val Ser Ser

115

<210> 240

<211> 354

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 240

cagcagctgg tggaaagcgg cggcggcctg gtgaaaccgg gcggcagcct gcgcctgagc 60

tgcgcggcga gcggctttac cattagcacc aacgcgatga gctgggtgcg ccaggcgccg 120

ggcaaaggcc tggaatgggt gggcgtgatt accggccgcg atattaccta ttatgcgagc 180

tgggcgaaag gccgctttac cattagcaaa accagcaaaa acaccgtgta tctgcagatg 240

aacagcctgc gcgcggaaga taccgcggtg tattattgcg cgcgcgatgg cggcagcagc 300

gcgattacca gcaacaacat ttggggccag ggcaccctgg tgaccgtgag cagc 354

<210> 241

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 241

Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Ser Cys Gln Ala Ser Glu Ser Ile Ser Ser Trp

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Glu Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro

65 70 75 80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gly Tyr Phe Tyr Phe Ile Ser

85 90 95

Arg Thr Tyr Val Asn Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 242

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 242

gatgtggtga tgacccagag cccgagcagc ctgagcgcga gcgtgggcga tcgcgtgacc 60

attagctgcc aggcgagcga aagcattagc agctggctgg cgtggtatca gcagaaaccg 120

ggccaggcgc cgaaactgct gatttatgaa gcgagcaaac tggcgagcgg cgtgccgagc 180

cgctttagcg gcagcggcag cggcaccgaa tttaccctga ccattagcag cctggaaccg 240

gaagattttg cgacctatta ttgccagggc tatttttatt ttattagccg cacctatgtg 300

aacagctttg gcggcggcac caaagtggaa attaaa 336

<210> 243

<211> 122

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 243

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly

20 25 30

Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

35 40 45

Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn

50 55 60

Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr

65 70 75 80

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr

85 90 95

Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp

100 105 110

Gly Gln Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 244

<211> 369

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 244

gaagtgcaat tgctcgaaag tggtggcgga cttgtgcaac ctggtggaag cctctcactc 60

tcttgcgcgg cgagtggttt tagcttcagt agcggctacg atatgtgctg ggtaagacag 120

gctcctggta aaggccttga gtggattgcg tgtatcgccg ccgggtctgc tggtataaca 180

tacgatgcaa actgggcgaa agggcgcttc acaatctcca gggacaactc aaaaaataca 240

ttgtacctcc agatgaatag cctgagagcc gaagacaccg cagtctacta ttgcgcaagg 300

tcagcattta gcttcgatta tgcaatggat ctttggggcc aggggacgct cgtcaccgtc 360

tcatcttga 369

<210> 245

<211> 110

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 245

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn

85 90 95

Val Asp Asn Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu

100 105 110

<210> 246

<211> 330

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 246

gacattcaga tgacacagtc accgtctacg ctctcagcct cagtaggcga tagggtgact 60

atcacctgcc aagcctccca atctataagt tcacacctca actggtatca acagaaaccc 120

ggtaaagcac cgaagctgct catctacaag gcatcaactc ttgcctcagg tgtgcctagt 180

cgcttctccg ggagcggctc cggtactgag tttactttga cgatatcttc cctccaaccc 240

gacgacttcg ccacatacta ttgtcagcag ggttatagtt ggggaaatgt tgacaatgtg 300

tttggagggg gaacgaaagt gactgtgttg 330

<210> 247

<211> 116

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 247

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr

20 25 30

His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile

35 40 45

Gly Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg

50 55 60

Gly Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu

65 70 75 80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95

Arg Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val

100 105 110

Thr Val Ser Ser

115

<210> 248

<211> 348

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 248

gaggttcagt tggttgaaag tgggggggga ctcgttcagc ctggaggctc tttgcgactt 60

tcttgtaccg cttctgggtt cactataagt tcatatcata tgcaatgggt aagacaggcg 120

cctggtaagg gacttgaata cataggaaca ataagctctg gtggtaacgt ctattacgcc 180

tcatccgcgc gggggaggtt tacaatttcc aggccttcta gcaaaaacac ggtagatctg 240

caaatgaact ctcttcgcgc tgaagataca gcagtctact actgcgccag ggattcaggg 300

tattctgacc ccatgtgggg gcagggcaca ttggttaccg tgtcctct 348

<210> 249

<211> 111

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 249

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr

20 25 30

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro

65 70 75 80

Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp

85 90 95

Tyr Val Gly Gly Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu

100 105 110

<210> 250

<211> 333

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 250

gacgttgtga tgacgcagtc tcctagttca gtatcagcgt ctgttgggga tcgagtcacg 60

attacatgcc aggcgagcca aaatattagg acgtatctgt cttggtatca acaaaagcct 120

ggtaaggctc caaaactcct catttacgcc gctgccaact tggctagtgg agtaccttca 180

cgctttagtg ggtcaggttc tggaacagat tttacgttga cgatctccga tttggaacca 240

ggggacgctg ccacgtatta ttgccagtcc acctacctcg ggactgacta cgttggtggg 300

gcgtttggcg gaggaacaaa actcactgta ctt 333

<210> 251

<211> 562

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 251

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp

1 5 10 15

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu

20 25 30

Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val

35 40 45

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val

50 55 60

Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg

65 70 75 80

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His

85 90 95

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr

100 105 110

Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly

115 120 125

Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val

130 135 140

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln

145 150 155 160

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala

165 170 175

Gly Leu Gly Ser Thr Gly Ser Gly Ser Lys Pro Gly Ser Gly Glu Gly

180 185 190

Ser Thr Lys Gly Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala

195 200 205

Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln

210 215 220

Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly

225 230 235 240

Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr

245 250 255

Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln

260 265 270

Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser

275 280 285

Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala

290 295 300

Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn

305 310 315 320

Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln

325 330 335

Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp

340 345 350

Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro

355 360 365

Glu Ile Pro Ala Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser

370 375 380

Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp Pro Ala Gly Leu Leu Asp

385 390 395 400

Leu Arg Gln Gly Met Phe Ala Gln Leu Val Ala Gln Asn Val Leu Leu

405 410 415

Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp Pro Gly Leu Ala Gly Val

420 425 430

Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu Asp Thr Lys Glu Leu Val

435 440 445

Val Ala Lys Ala Gly Val Tyr Tyr Val Phe Phe Gln Leu Glu Leu Arg

450 455 460

Arg Val Val Ala Gly Glu Gly Ser Gly Ser Val Ser Leu Ala Leu His

465 470 475 480

Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala Ala Ala Leu Ala Leu Thr

485 490 495

Val Asp Leu Pro Pro Ala Ser Ser Glu Ala Arg Asn Ser Ala Phe Gly

500 505 510

Phe Gln Gly Arg Leu Leu His Leu Ser Ala Gly Gln Arg Leu Gly Val

515 520 525

His Leu His Thr Glu Ala Arg Ala Arg His Ala Trp Gln Leu Thr Gln

530 535 540

Gly Ala Thr Val Leu Gly Leu Phe Arg Val Thr Pro Glu Ile Pro Ala

545 550 555 560

Gly Leu

<210> 252

<211> 1689

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 252

cgagagggcc ccgagctgtc tcctgatgac ccagcaggcc tcttggactt gcggcagggt 60

atgttcgctc aacttgtggc tcagaatgtt ctgctcattg atggaccact ctcttggtat 120

agtgaccccg gtctggccgg ggtgagtctg accggcgggc tctcttataa agaggatact 180

aaggaactgg tcgtagcaaa agcgggcgtt tattacgttt tttttcagct ggagctcagg 240

cgcgtggtgg ccggcgaggg cagtggctct gtgtccctgg ccctgcactt acagcccttg 300

agaagcgctg caggtgctgc cgcactggct ttaactgttg acctccctcc ggcctcttct 360

gaagctagaa acagcgcttt cggcttccaa gggcgcctgc tgcacctgag cgcaggccag 420

cgcttaggtg tgcaccttca tacagaggcc agggcccgac acgcttggca gctcacacag 480

ggtgccacgg ttctcggact tttccgcgtt actcccgaga tccccgctgg cctcggaagt 540

actggttctg ggtctaaacc cggttccggc gaaggtagta ctaaaggacg agaagggcca 600

gagttaagtc cagatgaccc tgctgggctt ttggacctgc ggcagggcat gttcgctcaa 660

ctggtggctc agaacgtgct gctgatcgat ggccccctga gttggtacag cgatcccggg 720

ctggcaggcg tgtcacttac agggggcctc tcttacaagg aagacaccaa ggagttagtg 780

gtcgctaagg ctggcgtgta ttacgtgttc ttccaactgg agctgagaag ggttgtggca 840

ggagagggta gcggcagcgt gtctttagcc cttcacttgc agcccctgag gtctgctgca 900

ggtgcagccg ctctcgcgct caccgtggat ctccccccag cctcatctga agctaggaac 960

agtgcatttg gctttcaggg acgcttgctg cacctctccg ctggacagag gctgggcgtg 1020

caccttcaca cagaggcccg tgccaggcat gcatggcagc tcactcaggg ggcaacagtg 1080

ctgggtctct tccgcgtgac tcctgaaata ccagctggac ttggcggtgg aggcagcggc 1140

ggaggaggat ctcgtgaggg gccagaactg tcccccgatg acccagccgg actgctcgat 1200

ctcagacagg gcatgttcgc tcagcttgta gcccaaaatg tcctcctgat tgacggccct 1260

ttgagctggt atagtgatcc cggcttggcc ggggtatctc tgaccggagg cctctcctac 1320

aaggaagaca ccaaagagct ggtggtggca aaagcggggg tgtattatgt gttctttcag 1380

ctcgagctgc ggagagttgt ggccggggaa gggtctggga gcgtatctct tgcacttcac 1440

ctgcagcccc tgcgcagcgc cgctggagcc gccgcccttg ctcttactgt ggatctgcct 1500

cctgcttcct cagaagcacg caacagcgcc ttcggctttc aaggacgtct cctgcacttg 1560

tccgcaggac agaggttggg cgtccatta cacactgagg cacggggcacg gcacgcttgg 1620

cagcttaccc agggagccac cgtgctggga ctctttagag tgacacccga gatccccgct 1680

ggcttgtga 1689

<210> 253

<211> 298

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 253

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Gly Gly Gly Gly Ser

130 135 140

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe

145 150 155 160

Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser

165 170 175

Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys

180 185 190

Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser

195 200 205

Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp

210 215 220

Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val

225 230 235 240

His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu

245 250 255

Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala

260 265 270

Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro

275 280 285

Asn Thr Tyr Ile Cys Met Gln Arg Thr Val

290 295

<210> 254

<211> 894

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 254

tttcttaatt cccttttcaa ccaagaggtt cagatcccct tgactgaaag ctattgcggc 60

ccttgtccga aaaactggat atgttacaag aataattgtt accaattctt cgacgaaagc 120

aagaactggt atgagagtca ggcgtcttgt atgagtcaga atgccagcct gcttaaggtt 180

tattcaaaag aagaccagga tctgcttaag ttggtaaaga gctaccactg gatggggctg 240

gtacatatcc caacgaatgg gtcatggcag tgggaggacg gttctattct gagtccaaat 300

ctcctgacga tcatcgaaat gcagaaaggg gactgtgccc tgtatgcatc atccttcaag 360

gggtacatcg agaactgcag taccccaaat acctacattt gtatgcaaag aacggttgga 420

ggcggtggct caggcggagg cggctcagga ggtggcggtt caggaggcgg cggatctttc 480

ctaaactcat tattcaacca agaagttcaa attcccttga ccgaaagtta ctgtggccca 540

tgtcctaaaa actggatatg ttacaaaaat aactgctacc aattttttga tgagagtaaa 600

aactggtatg agagccaggc ttcttgtatg tctcaaaatg ccagccttct gaaagtatac 660

agcaaagagg accaggattt acttaaactg gtgaagtcat atcattggat gggactagta 720

cacattccaa caaatggatc ttggcagtgg gaagatggct ccattctctc acccaaccta 780

ctaacaataa ttgaaatgca gaagggagac tgtgcactct atgcctcgag ctttaaaggc 840

tatatagaaa actgttcaac tccaaatacg tacatctgca tgcaaaggac tgtg 894

<210> 255

<211> 118

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 255

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr

20 25 30

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

35 40 45

Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr

100 105 110

Leu Val Thr Val Ser Ser

115

<210> 256

<211> 354

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 256

caggtgcaat tgcaggagtc ggggggaggc ctggtcaagc ctggagggtc cctgagcctc 60

tcctgtgcag cctctggatt cacctttagt agttattgga tgagctgggt ccgccaggct 120

ccagggaagg ggctggagtg ggtggccaac ataaaccgcg atggaagtgc gagttactat 180

gtggactctg tgaagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat 240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcgt 300

ggggtgggct acttcgatct ctggggccgt ggcaccctgg tcaccgtctc gagt 354

<210> 257

<211> 111

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 257

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu

100 105 110

<210> 258

<211> 333

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 258

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc cta 333

<210> 259

<211> 121

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 259

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala

1 5 10 15

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr

20 25 30

Asn Met His Trp Val Lys Gln Thr Pro Gly Arg Gly Leu Glu Trp Ile

35 40 45

Gly Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe

50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr

65 70 75 80

Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys

85 90 95

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asn Val Trp Gly

100 105 110

Ala Gly Thr Thr Val Thr Val Ser Ser

115 120

<210> 260

<211> 363

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 260

caggtgcagc tgcagcagcc cggcgccgag ctggtgaagc ccggcgccag cgtgaagatg 60

agctgcaagg ccagcggcta caccttcacc agctacaaca tgcactgggt gaagcagacc 120

cccggccggg gcctggagtg gatcggcgcc atctaccccg gcaacggcga caccagctac 180

aaccagaagt tcaagggcaa ggccaccctg accgccgaca agagcagcag caccgcctac 240

atgcagctga gcagcctgac cagcgaggac agcgccgtgt actactgcgc ccggagcacc 300

tactacggcg gcgactggta cttcaacgtg tggggcgccg gcaccaccgt gaccgtctcg 360

agc 363

<210> 261

<211> 106

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 261

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly

1 5 10 15

Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Ile

20 25 30

His Trp Phe Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr

35 40 45

Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly Ser

50 55 60

Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu

65 70 75 80

Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Thr Ser Asn Pro Pro Thr

85 90 95

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu

100 105

<210> 262

<211> 318

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 262

cagatcgtgc tgagccagag ccccgccatc ctgagcgcca gccccggcga gaaggtgacc 60

atgacctgcc gggccagcag cagcgtgagc tacatccact ggttccagca gaagcccggc 120

agcagcccca agccctggat ctacgccacc agcaacctgg ccagcggcgt gcccgtgcgg 180

ttcagcggca gcggcagcgg caccagctac agcctgacca tcagccgggt ggaggccgag 240

gacgccgcca cctactactg ccagcagtgg accagcaacc cccccacctt cggcggcggc 300

accaagctga ccgtgctg 318

<210> 263

<211> 124

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 263

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp

1 5 10 15

Ser Leu Ser Leu Ser Cys Leu Val Ser Gly Arg Ser Phe Asn Ser Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Ile Leu Trp Ser Gly Pro Thr Thr Tyr Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Ala Leu Gly Val Leu Val Leu Ala Pro Gly Asn Val Tyr Ser

100 105 110

Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser

115 120

<210> 264

<211> 372

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 264

gaggtgcagc tgcaggagtc tggcggcggc ctggtgcagg ctggggacag cctgagcctg 60

tcctgcctgg tgtctggccg ctccttcaac tcctacacca tgggctggtt ccgccaggcc 120

cctgggaagg agcgggagtt tgtggctgcc atcctgtgga gtggccccac cacctactat 180

gctgactctg tgaagggccg cttcaccatc tccagagaca atgccaagaa cactgtgtac 240

ctgcagatga acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgccctg 300

ggagtgctgg tgctggcccc tggcaatgtg tacagctact ggggccaggg cacccaggtg 360

actngtctcga gc 372

<210> 265

<211> 127

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 265

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly

1 5 10 15

Ser Leu Ser Leu Ser Cys Ala Phe Ser Gly Arg Thr Phe Ser Met Tyr

20 25 30

Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val

35 40 45

Ala Ala Asn Arg Gly Arg Gly Leu Ser Pro Asp Ile Ala Asp Ser Val

50 55 60

Asn Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr

65 70 75 80

Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Ala Asp Leu Gln Tyr Gly Ser Ser Trp Pro Gln Arg Ser Ser Ala

100 105 110

Glu Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser

115 120 125

<210> 266

<211> 381

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 266

caggtgcagc tggtgcagtc tggcggaggc ctggtgcagg ctgggggcag cctgagcctg 60

agctgtgcct tctctggccg caccttctcc atgtacacca tgggctggtt ccgccaggcc 120

ccagggaagg agagagagtt tgtggctgcc aacagaggca gaggcctgag cccagacatt 180

gctgactctg tgaatggccg cttcaccatc tccagagaca atgccaagaa caccctgtac 240

ctgcagatgg acagcctgaa gccagaggac acagctgtgt actactgtgc tgctgacctg 300

cagtatggca gcagctggcc tcagaggagc tctgctgagt atgactactg gggccagggc 360

accactgtga ctgtctcgag c 381

<210> 267

<211> 122

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 267

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Ser Gly

20 25 30

Tyr Asp Met Cys Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp

35 40 45

Ile Ala Cys Ile Ala Ala Gly Ser Ala Gly Ile Thr Tyr Asp Ala Asn

50 55 60

Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr

65 70 75 80

Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr

85 90 95

Tyr Cys Ala Arg Ser Ala Phe Ser Phe Asp Tyr Ala Met Asp Leu Trp

100 105 110

Gly Gln Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 268

<211> 366

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 268

gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60

tcctgtgcag cctctggatt ctccttcagt agcgggtacg acatgtgctg ggtccgccag 120

gctccaggga agtgcctgga gtggatcgca tgcattgctg ctggtagtgc tggtatcact 180

tacgacgcga actgggcgaa aggccggttc accatctcca gagacaattc caagaacacg 240

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtatatta ctgtgcgaga 300

tcggcgtttt cgttcgacta cgccatggac ctctggggcc agggaaccct ggtcaccgtc 360

tcgtct 366

<210> 269

<211> 110

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 269

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser His

20 25 30

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Lys Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Trp Gly Asn

85 90 95

Val Asp Asn Val Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 270

<211> 333

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 270

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggccagtca gagcattagt tcccacttaa actggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctataag gcatccactc tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa tttactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaacag ggttatagtt ggggtaatgt tgataatgtt 300

ttcggctgcg ggaccaaggt ggagatcaaa tag 333

<210> 271

<211> 115

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 271

Arg Ser Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser

1 5 10 15

Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Ile Ser Ser Tyr His

20 25 30

Met Gln Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Tyr Ile Gly

35 40 45

Thr Ile Ser Ser Gly Gly Asn Val Tyr Tyr Ala Ser Ser Ala Arg Gly

50 55 60

Arg Phe Thr Ile Ser Arg Pro Ser Ser Lys Asn Thr Val Asp Leu Gln

65 70 75 80

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg

85 90 95

Asp Ser Gly Tyr Ser Asp Pro Met Trp Gly Gln Gly Thr Leu Val Thr

100 105 110

Val Ser Ser

115

<210> 272

<211> 345

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 272

cggtcgctgg tggagtctgg gggaggcttg gtccagcctg gggggtccct gagactctcc 60

tgtactgcct ctggattcac catcagtagc taccacatgc agtgggtccg gcaggcacct 120

gggaagtgcc tggagtacat cggaaccatt agtagtggtg gtaatgtata ctacgcaagc 180

tccgctagag gcagattcac catctccaga ccctcgtcca agaacacggt ggatcttcaa 240

atgaacagcc tgagagccga ggacacggct gtgtattact gtgcgagaga ctctggttat 300

agtgatccta tgtggggcca gggaaccctg gtcaccgtct cttca 345

<210> 273

<211> 111

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 273

Asp Val Val Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asn Ile Arg Thr Tyr

20 25 30

Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Ala Ala Ala Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asp Leu Glu Pro

65 70 75 80

Gly Asp Ala Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Leu Gly Thr Asp

85 90 95

Tyr Val Gly Gly Ala Phe Gly Cys Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 274

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 274

gacgttgtga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc 60

atcacctgtc aggccagtca gaacattagg acttacttat cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgct gcagccaatc tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcga cttggaacct 240

ggcgatgctg caacttacta ttgtcagtct acctatcttg gtactgatta tgttggcggt 300

gctttcggct gtgggaccaa ggtggagatc aaatga 336

<210> 275

<211> 118

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 275

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr

20 25 30

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val

35 40 45

Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly Arg Gly Thr

100 105 110

Leu Val Thr Val Ser Thr

115

<210> 276

<211> 354

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 276

caggtgcaat tgcaggagtc ggggggaggc ctggtcaagc ctggagggtc cctgagactc 60

tcctgtgcag cctctggatt cacctttagt agttattgga tgagctgggt ccgccaggct 120

ccagggaagt gcctggagtg ggtggccaac ataaaccgcg atggaagtgc gagttactat 180

gtggactctg tgaagggccg attcaccatc tccagagacg acgccaagaa ctcactgtat 240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatcgt 300

ggggtgggct acttcgatct ctggggccgt ggcaccctgg tcaccgtgtc gaca 354

<210> 277

<211> 111

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 277

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Cys Gly Thr Lys Val Thr Val Leu

100 105 110

<210> 278

<211> 333

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 278

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggct gtgggaccaa ggtgaccgtc cta 333

<210> 279

<211> 122

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 279

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Thr

20 25 30

Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

35 40 45

Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser

50 55 60

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu

65 70 75 80

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

85 90 95

Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu Trp

100 105 110

Gly Gln Gly Thr Leu Val Thr Val Ser Ser

115 120

<210> 280

<211> 366

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 280

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60

tcctgtgcag cctctggatt ctccttcagt ggcacccagt acgtgtgctg ggtccgccag 120

gctccaggga aggggctgga gtggatcgga tgcatttatg tggatgtggc taacacttac 180

tacgcgacct ccgtgaaggg cagattcacc atctccagag acaattccaa gaacacgctg 240

tatcttcaaa tgaacagcct gagagccgag gacacggctg tgtattactg tgcgagtcat 300

gatactgttt gtgctggttg tggtttggac ttgtggggcc agggaaccct ggtcaccgtc 360

tcgagc 366

<210> 281

<211> 111

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 281

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile

85 90 95

Ile Tyr Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 282

<211> 333

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 282

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300

gctttcggcg gagggaccaa ggtggagatc aaa 333

<210> 283

<211> 120

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 283

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr

20 25 30

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val

35 40 45

Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val

50 55 60

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr

65 70 75 80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys

85 90 95

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln

100 105 110

Gly Thr Leu Val Thr Val Ser Thr

115 120

<210> 284

<211> 360

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 284

gaagtacagc ttgttgagag tggtggtgga cttgtccaac cagggggaag tctgcggctg 60

tcatgcgcag cctctggctt caacattaag gacacctaca ttcactgggt tcggcaagcg 120

ccggggaagg ggctggaatg ggtcgccagg atatacccta ccaacgggta caccaggtat 180

gcagatagcg ttaagggtag attcactatt tcagctgaca ctagcaagaa caccgcgtat 240

ctccagatga actcccttcg cgccgaggat acggctgtgt actactgctc taggtgggga 300

ggagatgggt tttacgcaat ggattactgg ggacagggaa cactcgttac ggtgtcgaca 360

<210> 285

<211> 107

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 285

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala

20 25 30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro

85 90 95

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105

<210> 286

<211> 321

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 286

gacatccaaa tgacgcagtc tccctccagt ttgagtgcaa gtgtgggaga cagagttacg 60

atcacatgta gggcaagtca ggacgtcaat acagccgtcg catggtacca gcagaagcct 120

ggaaaggccc cgaaacttct gatttactct gcaagtttcc tctacagtgg tgttcctagt 180

cgcttcagtg ggtctcggtc aggcaccgat tttaccctga caattagcag cttgcaaccg 240

gaagatttg cgacctatta ttgccagcaa cattatacca cccctcccac atttggacaa 300

ggcacgaagg tagagattaa a 321

<210> 287

<211> 451

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 287

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly

1 5 10 15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Gly Thr

20 25 30

Gln Tyr Val Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp

35 40 45

Ile Gly Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser

50 55 60

Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu

65 70 75 80

Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr

85 90 95

Cys Ala Ser His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu Trp

100 105 110

Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro

115 120 125

Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr

130 135 140

Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr

145 150 155 160

Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro

165 170 175

Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr

180 185 190

Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn

195 200 205

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser

210 215 220

Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala

225 230 235 240

Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu

245 250 255

Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser

260 265 270

His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu

275 280 285

Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr

290 295 300

Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn

305 310 315 320

Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro

325 330 335

Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln

340 345 350

Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val

355 360 365

Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val

370 375 380

Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro

385 390 395 400

Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr

405 410 415

Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val

420 425 430

Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu

435 440 445

Ser Pro Gly

450

<210> 288

<211> 1356

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 288

gaggtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc 60

tcctgtgcag cctctggatt ctccttcagt ggcacccagt acgtgtgctg ggtccgccag 120

gctccaggga aggggctgga gtggatcgga tgcatttatg tggatgtggc taacacttac 180

tacgcgacct ccgtgaaggg cagattcacc atctccagag acaattccaa gaacacgctg 240

tatcttcaaa tgaacagcct gagagccgag gacacggctg tgtattactg tgcgagtcat 300

gatactgttt gtgctggttg tggtttggac ttgtggggcc agggaaccct ggtcaccgtc 360

tcgagcgcta gcaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420

tctggggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480

gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540

tcctcaggac tctactccct cagcagcgtg gtgaccgtgc cctccagcag cttgggcacc 600

cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagagagtt 660

gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaagccgcg 720

ggggcaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggagggagcag 900

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960

ggcaaggagt acaagtgcgc ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200

cccgtgctgg actccgacgg ctccttcttc ctctatagca agctcaccgt ggacaagagc 1260

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320

tacacgcaga agagcctctc cctgtctccg ggttaa 1356

<210> 289

<211> 218

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 289

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asn Ile Tyr Ser Asn

20 25 30

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile

35 40 45

Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly

50 55 60

Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro

65 70 75 80

Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Thr Tyr Tyr Asn Asn Ile

85 90 95

Ile Tyr Gly Ala Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg

100 105 110

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln

115 120 125

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr

130 135 140

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser

145 150 155 160

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr

165 170 175

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys

180 185 190

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro

195 200 205

Val Thr Lys Ser Phe Asn Arg Gly Glu Cys

210 215

<210> 290

<211> 657

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 290

gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc 60

atcacttgcc aggccagtga gaacatttac agcaatttag cctggtatca gcagaaacca 120

gggaaagccc ctaagctcct gatctatgat gcttccactc tggcatctgg ggtcccatca 180

aggttcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240

gatgattttg caacttatta ctgccaatct acttattata ataatatcat ttatggggct 300

gctttcggcg gagggaccaa ggtggagatc aaacgtacgg tggctgcacc atctgtcttc 360

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg 420

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg 480

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc 540

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc 600

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgttag 657

<210> 291

<211> 112

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 291

Gln Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser

1 5 10 15

Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Leu Ser Ser Asn Ala

20 25 30

Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly

35 40 45

Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly

50 55 60

Arg Phe Thr Ile Ser Arg Ser Lys Asn Thr Val Tyr Leu Gln Met Asn

65 70 75 80

Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly

85 90 95

Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser

100 105 110

<210> 292

<211> 336

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 292

caacagttgg ttgagtctgg tggcggtctc gttaagcctg gagggtccct tcggcttagt 60

tgtgcggcct ctgggatcga cctgtctagc aacgctatag gatgggtacg gcaagctccg 120

ggcaaaggcc ttgagtgggt cggcgttatt tttgggagcg gtaatacgta ctacgccagc 180

tgggcaaaag gtaggttcac tatcagtcga tcaaagaaca cggtatatct tcagatgaac 240

agtctccggg cggaggacac cgcggtttat tattgcgcaa gggggggata ctcctcagac 300

atatggggcc aaggtacttt ggtgacggtc tcgagc 336

<210> 293

<211> 110

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 293

Asp Pro Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly

1 5 10 15

Asp Arg Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Ala Lys Asn

20 25 30

Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Lys Leu

35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro Ser Arg Phe

50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val

65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg Asp Ser Gly

85 90 95

Asn Ile Gln Ser Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 110

<210> 294

<211> 330

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 294

gatccagttc tgacacaaag tccatccagc ctgtctgcct cagtcggcga cagagtgacc 60

atcagttgcc agagctcaca gtctgtggct aagaacaaca acttggcgtg gttccaacag 120

aaacctggac aggctccgaa attgctgatc tattctgctt ccacgcttgc tgctggtgtt 180

ccttcccgct tttcaggtag tggtagcggg acagacttca ctttgactat aagcagcgtg 240

cagcctgaag attttgcgac ctactattgt tctgctagag acagtggaaa tattcagtcc 300

tttgggggggg gaacgaaggt cgaaataaag 330

<210> 295

<211> 139

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 295

Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu

1 5 10 15

Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn

20 25 30

Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala

35 40 45

Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu

50 55 60

Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu

65 70 75 80

Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile

85 90 95

Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys

100 105 110

Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr

115 120 125

Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val

130 135

<210> 296

<211> 417

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 296

tttctgaata gcctgttcaa cccaggaggtg cagatcccac tgaccgagag ctattgtgga 60

ccttgtccta agaactggat ctgttacaag aacaactgct accagttctt cgacgagagc 120

aagaattggt atgaaagcca ggccagctgc atgagccaaa acgcctctct gctgaaggtg 180

tactccaaag aagatcagga cctgctgaag ctggtgaagt cctaccactg gatgggcctg 240

gtgcacatcc caaccaacgg cagctggcag tgggaagacg gcagcatcct gagccctaac 300

ctgctgacaa tcattgagat gcagaaaggc gactgcgccc tgtacgccag ttcttttaag 360

ggctacatcg aaaactgtag cacccctaac acctacatct gcatgcagag aacagtg 417

<210> 297

<211> 439

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 297

Gln Val Gln Leu Gln Glu Ser Gly Gly Arg Leu Val Gln Pro Gly Glu

1 5 10 15

Pro Leu Ser Leu Thr Cys Lys Thr Ser Gly Ile Asp Leu Ser Ser Asn

20 25 30

Ala Ile Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile

35 40 45

Gly Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys

50 55 60

Gly Arg Phe Thr Ile Ser Arg Ser Thr Ser Thr Val Tyr Leu Lys Met

65 70 75 80

Asn Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Gly

85 90 95

Gly Tyr Ser Ser Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser

100 105 110

Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser

115 120 125

Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp

130 135 140

Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr

145 150 155 160

Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr

165 170 175

Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys

180 185 190

Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp

195 200 205

Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala

210 215 220

Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro

225 230 235 240

Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val

245 250 255

Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val

260 265 270

Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln

275 280 285

Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln

290 295 300

Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly

305 310 315 320

Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro

325 330 335

Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr

340 345 350

Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser

355 360 365

Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr

370 375 380

Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val

385 390 395 400

Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe

405 410 415

Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys

420 425 430

Ser Leu Ser Leu Ser Leu Gly

435

<210> 298

<211> 1320

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 298

caagtgcagt tgcaagaaag tggtggtaga ctggttcagc ctggtgaacc cttgtcactg 60

acgtgtaaaa caagcggcat tgatctgtcc tctaacgcca tcggatgggt ccgacaggcc 120

caggaaaag gtctggagtg gatcggagtt atcttcggga gcggcaatac atactacgca 180

agctgggcaa aagggcgatt tacgatatca cggagcacct ctacagttta tttgaaaatg 240

aactccctcc ggtccgagga taccgcgata tattactgtg ccagagggg gtactcctct 300

gatatctggg ggcagggtac actggttaca gtttcatccg ctagcaccaa gggaccctct 360

gtgtttcctc tggctccttg ctccagatcc acctccgagt ctacagctgc tctgggctgc 420

ctggtcaagg actactttcc tgagcctgtg accgtgtcct ggaactctgg cgctctgaca 480

tctggcgtgc acacctttcc agctgtgctg cagtcctccg gcctgtactc tctgtcctct 540

gtcgtgaccg tgccttcctc tagcctgggc accaagacct acacctgtaa tgtggaccac 600

aagccttcca acaccaaggt ggacaagcgc gtggaatcta agtacggccc tccttgtcct 660

ccatgtcctg ctccagaagc tgctggcggc ccatccgtgt ttctgttccc tccaaagcct 720

aaggacaccc tgatgatctc tcggacccct gaagtgacct gcgtggtggt ggatgtgtcc 780

caagaggatc ccgaggtgca gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc 840

aagaccaagc ctagagagga acagttcaac tccacctaca gagtggtgtc cgtgctgacc 900

gtgctgcacc aggattggct gaacggcaaa gagtacaagt gcaaggtgtc caacaagggc 960

ctgccttcca gcatcgaaaa gaccatctcc aaggccaagg gccagcctag ggaaccccag 1020

gtttacaccc tgcctccaag ccaagaggaa atgaccaaga accaggtgtc cctgtcctgc 1080

gccgtgaagg gcttctaccc ttccgatatc gccgtggaat ggggagagcaa tggccagcct 1140

gagaacaact acaagacaac ccctcctgtg ctggactccg acggctcctt cttcctggtg 1200

tcccgcctga ccgtggacaa gtccagatgg caagagggca acgtgttctc ctgctccgtg 1260

atgcacgagg ccctgcacaa tcactacacc cagaagtccc tgtctctgtc cctgggatga 1320

<210> 299

<211> 702

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 299

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln

1 5 10 15

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr

20 25 30

Asn Phe Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu

35 40 45

Met Ile Tyr Asp Val Ser Asp Arg Pro Ser Gly Val Ser Asp Arg Phe

50 55 60

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Ile Ile Ser Gly Leu

65 70 75 80

Gln Ala Asp Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Gly Ser Ser

85 90 95

Ser Thr His Val Ile Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly

100 105 110

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly

115 120 125

Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys

130 135 140

Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

145 150 155 160

Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

165 170 175

Glu Trp Val Ala Asn Ile Asn Arg Asp Gly Ser Ala Ser Tyr Tyr Val

180 185 190

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn

195 200 205

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

210 215 220

Tyr Tyr Cys Ala Arg Asp Arg Gly Val Gly Tyr Phe Asp Leu Trp Gly

225 230 235 240

Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly

245 250 255

Gly Gly Ser Asp Pro Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala

260 265 270

Thr Val Gly Gln Arg Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val

275 280 285

Ala Lys Asn Asn Asn Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Pro

290 295 300

Pro Lys Leu Leu Ile Tyr Ser Ala Ser Thr Leu Ala Ala Gly Val Pro

305 310 315 320

Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile

325 330 335

Thr Arg Val Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ser Ala Arg

340 345 350

Asp Ser Gly Asn Ile Gln Ser Phe Gly Gly Gly Thr Arg Val Glu Ile

355 360 365

Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp

370 375 380

Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn

385 390 395 400

Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu

405 410 415

Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp

420 425 430

Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr

435 440 445

Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser

450 455 460

Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Pro

465 470 475 480

Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val

485 490 495

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr

500 505 510

Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu

515 520 525

Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys

530 535 540

Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser

545 550 555 560

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys

565 570 575

Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile

580 585 590

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro

595 600 605

Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu

610 615 620

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn

625 630 635 640

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser

645 650 655

Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg

660 665 670

Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu

675 680 685

His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly

690 695 700

<210> 300

<211> 2109

<212> DNA

<213> Artificial sequence

<220>

<223> Synthesized

<400> 300

cagtctgccc tgactcagcc tgcctccgtg tctgggtctc ctggacagtc gatcaccatc 60

tcctgcactg gaaccagcag tgacgttggt ggttataact ttgtctcctg gtaccaacaa 120

cacccaggca aagcccccaa actcatgatc tatgatgtca gtgatcggcc ctcaggggtg 180

tctgatcgct tctccggctc caagtctggc aacacggcct ccctgatcat ctctggcctc 240

caggctgacg acgaggctga ttattactgc agctcatatg ggagcagcag cactcatgtg 300

attttcggcg gagggaccaa ggtgaccgtc ctaggcggtg gcggtagtgg gggaggcggt 360

tctggcggcg gagggtccgg cggtggagga tcacaggtgc aattgcagga gtcgggggga 420

ggcctggtca agcctggagg gtccctgagc ctctcctgtg cagcctctgg attcaccttt 480

agtagttatt ggatgagctg ggtccgccag gctccaggga aggggctgga gtgggtggcc 540

aacataaacc gcgatggaag tgcgagttac tatgtggact ctgtgaaggg ccgattcacc 600

atctccagag acgacgccaa gaactcactg tatctgcaaa tgaacagcct gagagctgag 660

gacacggctg tgtattactg tgcgagagat cgtggggtgg gctacttcga tctctggggc 720

cgtggcaccc tggtcaccgt ctcgagtggc ggtggagggt ccggcggtgg tggatcagat 780

cctcaattga cccagtcccc tagtagcctt tctgcaaccg tgggccagag ggtaacaatc 840

aattgccagt caagccagtc cgtagcgaag aataataatt tggcatggtt ccaacaaaaa 900

ccgggtaaac ctcctaaact ccttatctac tcagcttcaa cccttgccgc gggtgtgccc 960

agccggttct caggctcagg ttccgggact caatttacac ttaccatcac tcgcgtccaa 1020

agtgaggatt ttgcaaccta ctattgttct gcacgggatt ccgggaacat acagtccttt 1080

gggggtggaa ctcggggtgga gataaaacgt acggtggctg caccatctgt cttcatcttc 1140

ccgccatctg atgagcagtt gaaatctgga actgcctctg ttgtgtgcct gctgaataac 1200

ttctatccca gagaggccaa agtacagtgg aaggtggata acgccctcca atcgggtaac 1260

tcccaggaga gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 1320

ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga agtcacccat 1380

cagggcctga gctcgcccgt cacaaagagc ttcaacaggg gagagtgtgg cggcggacct 1440

ccttgtcctc catgtcctgc tccagaagct gctggcggcc catccgtgtt tctgttccct 1500

ccaaagccta aggacaccct gatgatctct cggacccctg aagtgacctg cgtggtggtg 1560

gatgtgtccc aagaggatcc cgaggtgcag ttcaattggt acgtggacgg cgtggaagtg 1620

cacaacgcca agaccaagcc tagagaggaa cagttcaact ccacctacag agtggtgtcc 1680

gtgctgaccg tgctgcacca ggattggctg aacggcaaag agtacaagtg caaggtgtcc 1740

aacaagggcc tgccttccag catcgaaaag accatctcca aggccaaggg ccagcctagg 1800

gaaccccagg tttacaccct gcctccaagc caagaggaaa tgaccaagaa ccaggtgtcc 1860

ctgtggtgcc tcgtgaaggg cttctaccct tccgatatcg ccgtggaatg ggagagcaat 1920

ggccagcctg agaacaacta caagacaacc cctcctgtgc tggactccga cggctccttc 1980

ttcctgtatt cccgcctgac cgtggacaag tccagatggc aagagggcaa cgtgttctcc 2040

tgctccgtga tgcacgaggc cctgcacaat cgcttcaccc agaagtccct gtctctgtcc 2100

ctgggatga 2109

<210> 301

<211> 6

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 301

Gly Thr Gln Tyr Val Cys

1 5

<210> 302

<211> 17

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 302

Cys Ile Tyr Val Asp Val Ala Asn Thr Tyr Tyr Ala Thr Ser Val Lys

1 5 10 15

Gly

<210> 303

<211> 12

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 303

His Asp Thr Val Cys Ala Gly Cys Gly Leu Asp Leu

1 5 10

<210> 304

<211> 11

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 304

Gln Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala

1 5 10

<210> 305

<211> 7

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 305

Asp Ala Ser Thr Leu Ala Ser

1 5

<210> 306

<211> 13

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 306

Gln Ser Thr Tyr Tyr Asn Asn Ile Ile Tyr Gly Ala Ala

1 5 10

<210> 307

<211> 5

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 307

Ser Asn Ala Ile Gly

1 5

<210> 308

<211> 16

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 308

Val Ile Phe Gly Ser Gly Asn Thr Tyr Tyr Ala Ser Trp Ala Lys Gly

1 5 10 15

<210> 309

<211> 7

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 309

Gly Gly Tyr Ser Ser Asp Ile

1 5

<210> 310

<211> 13

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 310

Gln Ser Ser Gln Ser Val Ala Lys Asn Asn Asn Leu Ala

1 5 10

<210> 311

<211> 7

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 311

Ser Ala Ser Thr Leu Ala Ala

1 5

<210> 312

<211> 10

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 312

Ser Ala Arg Asp Ser Gly Asn Ile Gln Ser

1 5 10

<210> 313

<211> 329

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 313

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys

1 5 10 15

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr

20 25 30

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser

35 40 45

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser

50 55 60

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr

65 70 75 80

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys

85 90 95

Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys

100 105 110

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro

115 120 125

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys

130 135 140

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp

145 150 155 160

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu

165 170 175

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu

180 185 190

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn

195 200 205

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly

210 215 220

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu

225 230 235 240

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr

245 250 255

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn

260 265 270

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe

275 280 285

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn

290 295 300

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr

305 310 315 320

Gln Lys Ser Leu Ser Leu Ser Pro Gly

325

<210> 314

<211> 326

<212> Protein

<213> Artificial sequence

<220>

<223> Synthesized

<400> 314

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg

1 5 10 15

Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr

20 25 30

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser

35 40 45

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser

50 55 60

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr

65 70 75 80

Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys

85 90 95

Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro

100 105 110

Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys

115 120 125

Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val

130 135 140

Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp

145 150 155 160

Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe

165 170 175

Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp

180 185 190

Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu

195 200 205

Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg

210 215 220

Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys

225 230 235 240

Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp

245 250 255

Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys

260 265 270

Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser

275 280 285

Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser

290 295 300

Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser

305 310 315 320

Leu Ser Leu Ser Leu Gly

325

<---

Claims (37)

1. A penta-specific antibody-like protein that is a T-cell-attracting activator, where the protein has an N-terminus and a C-terminus and contains a first monomer comprising from N-terminus to C-terminus a first binding monomer, a CH1 domain, a first hinge, a first CH2 domain and a first CH3 domain, wherein the first monomer comprises a first binding domain (D1) linked to the N-terminus and a fourth binding domain (D4) linked to the C-terminus, a second monomer comprising from N-terminus to C-terminus a second binding monomer, a CL domain, a second hinge, a second CH2 domain and a second CH3 domain, wherein the second monomer comprises a second binding domain (D2) linked to the N-terminus and a fifth binding domain (D5) linked to the C-terminus, where the first linking monomer and the second linking monomer are in a configuration that forms a dimer, wherein the first monomer and the second monomer are covalently linked and form a pair via at least one disulfide bond between the CH1 domain and the CL domain and at least one disulfide bond between the first hinge and the second hinge, and wherein the first binding monomer comprises a VH domain, the second binding monomer comprises a VL domain, and wherein the VH, CH1, VL, CL domains form a Fab region as a third binding domain (D3); or wherein the first binding monomer and the second binding monomer form an NKG2D receptor as a third binding domain (D3), wherein the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:17 and the amino acid sequence of SEQ ID NO:19, wherein D1 has binding specificity for CD3, D2 has binding specificity for HER3, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:21 and the amino acid sequence of SEQ ID NO:23, wherein D1 has binding specificity for EGFR, D2 has binding specificity for HER3, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:25 and the amino acid sequence of SEQ ID NO:27, wherein D1 has binding specificity for EGFR, D2 has binding specificity for HER3, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:29 and the amino acid sequence of SEQ ID NO:31, wherein D1 has binding specificity for EGFR, D2 has binding specificity for CD3, D3 has binding specificity for HER3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:69 and the amino acid sequence of SEQ ID NO:71, wherein D1 has binding specificity for EGFR, D2 has binding specificity for CD19, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:73 and the amino acid sequence of SEQ ID NO:75, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:77 and the amino acid sequence of SEQ ID NO:79, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:81 and the amino acid sequence of SEQ ID NO:83, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:85 and the amino acid sequence of SEQ ID NO:87, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:89 and the amino acid sequence of SEQ ID NO:91, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 has binding specificity for EGFR, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:93 and the amino acid sequence of SEQ ID NO:95, wherein D1 has binding specificity for EGFR, D2 has binding specificity for HER3, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:97 and the amino acid sequence of SEQ ID NO:99, wherein D1 has binding specificity for EGFR, D2 has binding specificity for HER3, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:129 and the amino acid sequence of SEQ ID NO:131, wherein D1 has binding specificity for CD20, D2 has binding specificity for CD19, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:133 and the amino acid sequence of SEQ ID NO:135, wherein D1 has binding specificity for CD20, D2 has binding specificity for CD19, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:149 and the amino acid sequence of SEQ ID NO:151, wherein D1 has binding specificity for EGFR, D2 has binding specificity for HER3, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:169 and the amino acid sequence of SEQ ID NO:171, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 is an NKG2D receptor, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:173 and the amino acid sequence of SEQ ID NO:175, wherein D1 is an NKG2D receptor, D2 has binding specificity for CD19, D3 has binding specificity for CD3, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI, or the penta-specific antibody-like protein has the amino acid sequence of SEQ ID NO:177 and the amino acid sequence of SEQ ID NO:179, wherein D1 has binding specificity for CD3, D2 has binding specificity for CD19, D3 is an NKG2D receptor, D4 has binding specificity for 4-1BB, D5 has binding specificity for PD-LI. 2. The protein of claim 1, wherein the first CH3 domain is in a configuration that forms a structure with a pit, where the second CH3 domain is in a configuration that produces a protruding structure, and where the first CH2 and CH3 domains and the second CH2 and CH3 domains are in a configuration in which heterodimerization occurs to form a complementary Fc domain. 3. The protein of claim 1, wherein D1, D2, D4 and D5 independently represent an scFv domain, a VHH domain, a receptor or a ligand. 4. An isolated nucleic acid molecule encoding a protein according to any one of claims 1-3. 5. An expression vector containing the isolated nucleic acid molecule according to paragraph 4. 6. A host cell for producing a protein according to claim 1 or 2, wherein the cell contains a vector according to claim 5. 7. An immunoconjugate for the treatment or prevention of cancer, an autoimmune disease or an infectious disease, wherein the immunoconjugate comprises a penta-specific antibody-like protein according to any one of claims 1 to 3 and a cytotoxic agent. 8. A pharmaceutical composition for the treatment or prevention of cancer, an autoimmune disease or an infectious disease in humans, wherein the composition comprises the protein according to claim 1 or 2 and a pharmaceutically acceptable carrier. 9. A pharmaceutical composition for the treatment or prevention of cancer, an autoimmune disease or an infectious disease in humans, comprising an immunoconjugate according to claim 7 and a pharmaceutically acceptable carrier. 10. A method for producing a penta-specific antibody-like protein according to claim 1 or 2, comprising: culturing the host cell according to claim 6 and expressing a DNA sequence encoding the protein according to any one of claims 1 or 2, and purification of the said penta-specific antibody-like protein.