RU2832940C2 - Apparatus and method for plasma activation of liquid - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to an apparatus and a method for plasma activation of a liquid for use on a patient. Plasma (30) is generated by means of plasma generator (34). Liquid (F) is brought into contact with plasma (30) in device (25) of plasma action and liquid is supplied to tool (11). During and/or after exposure to plasma on liquid in device (25) of plasma exposure by means of sensor device (36) at least one chemical or physical parameter of liquid (F) is recorded. Control device (19) connected at the input to sensor device (36) and at the output to plasma generator (34) controls the operation of plasma generator (34) with respect to the amplitude coefficient or the shape of the curve of the current output by it or the voltage output by it depending on the recorded parameter of the liquid (F) for the effect on said parameter. Thus, it is possible to obtain a plasma-treated liquid (F) with given characteristics for treating a patient.

EFFECT: plasma discharge control in order to obtain liquid with specified parameters.

14 cl, 2 dwg

Description

The invention relates to an apparatus and method for plasma activation of a liquid for the purpose of its use on a patient.

By acting on a liquid, such as a NaCl solution, lactated Ringer's solution or another liquid, plasma can convert this liquid into a plasma-activated state. In this case, the liquid will contain reactive agents with medical effectiveness, such as radicals with an increased oxidation-reduction potential, as well as substances such as peroxides, peroxynitrites, nitrates, nitrites, nitrogen oxides (oxygen- or nitrogen-centered reactive agents). Liquids activated in this way can be used for indirect plasma therapy. The effect on the tissue being treated can be disinfectant. Such a liquid can inactivate microbial and bacterial organisms. In addition, the treatment can be based on the fact that the plasma-activated liquid acts differently on pathogenic and healthy cells. The basis for this difference in action is the nature of the chemical agents contained in the plasma-activated liquid.

In order to obtain plasma-activated liquids, publication WO 2015/123720 A1 proposes to act on the gel surface with plasma. In particular, non-thermal, so-called cold plasmas containing a highly active mixture of oxygen, nitrogen and hydrogen radicals, ions, electrons, photons and ultraviolet radiation are mentioned.

Publications US 2012/0111721 A1 and WO 2007/117634 A2 propose a device for plasma treatment of liquid. Plasma treatment is carried out in a rotationally symmetric vessel, along the wall of which a thin liquid film flows. In this case, a discharge occurs between two graphite electrodes, the resulting radiation acting on the liquid.

Publication EP 1702678 A1 proposes to treat a liquid film with electron beams in a vacuum vessel. As an alternative, this publication discusses treating the liquid film with radiation from a UV source provided instead of or in addition to the electron beam source.

In the publication EP 2937103 A1 it is proposed to activate the active medium, for example a wound pad, with plasma. For this purpose, the wound pad may contain a plasma-activated gel, a plasma-activated liquid or a plasma-activated substrate impregnated with a fluid medium. Due to the plasma treatment of the active medium, the active substance is formed or released in it. The active media may be water-based liquids, physiological solutions and gels obtained from them. For plasma treatment, a plasma generator is provided that produces, for example, cold plasma at atmospheric pressure. This plasma is supplied to the surface of the active medium. After activation, the wound pad can be applied to the patient.

The publications US 2019/0110933 A1 and WO 2017/167748 A1 propose to treat wounds by the combined use of plasma and vacuum. For this purpose, a vacuum therapy device is connected to an atmospheric source of antimicrobacterial and wound-healing plasma, and a sensor device can be provided to record the wound healing process. For this purpose, the sensor system can record at least one physical parameter on the surface of the patient's body. Based on this recorded parameter, the state of the wound is judged. The recorded parameters can be, in particular, temperature, pressure, humidity and/or the pH value.

The problem of deterioration of the medical effectiveness of plasma-activated liquids during long-term storage is known from the publication WO 2017/074979 A1. In order to ensure the suitability of such plasma-activated liquids for longer storage, it is proposed to use liquids with a reduced content of cysteine, methionine, phenylalanine and phenol red in their composition and with the addition of 3-nitro-L-tyrosine for plasma activation.

The publications US 2014/0322096 A1 and WO 2014/055812 A1 describe a disinfection system, in particular for disinfecting the hands of surgeons. For this purpose, a reaction vessel is provided in which a barrier discharge occurs between two insulated electrodes. A sprayed cleaning liquid is passed through the resulting plasma, which collects at the bottom of the vessel and can then be dispensed through nozzles for hand disinfection.

Publication US 2015/0306258 A1 describes a method for sterilizing corneal tissue before transplantation. To do this, the tissue is exposed to a plasma-activated fluid. To plasma-activate the fluid, it is passed in a sprayed state in the form of a spray cone through a cold plasma discharge before being applied to the cornea.

Publication WO 2017/091534 A1 describes a method and system for killing or inactivating spores by applying a liquid containing an additive to a surface to be sterilized to maintain plasma activation for a period of at least 30 seconds. The additive may be, for example, a nitrite, a bioactive oil, an acid, a transition metal, or an enzyme.

In contrast to these solutions, publications WO 2014/145570 A1 and WO 2014/152256 A1 propose to directly affect the water surface with plasma, resulting in the formation of radicals in the water. Such plasma-activated water can be used for disinfecting surfaces.

Publication WO 2017/083323 A1 is also devoted to obtaining a plasma-activated liquid. For this purpose, a device is provided in which an aerosol consisting of a gas and a liquid is passed by one or more plasma generators to activate the gas and/or liquid. A separating device is provided to separate the gas and liquid after plasma treatment. The liquid can be used for disinfection purposes. A barrier discharge is used to create plasma.

Publication WO 2018/089577 A1 is devoted to systems and methods for plasma activation of liquids, wherein the activation must provide particularly high concentrations, and large quantities of liquid must be activated. For this purpose, a device is provided that transfers the liquid into a thin layer, near which plasma is created.

From the publication US 2019/0279849 A1, plasma activation of liquid by discharge is known, in which current flows from the electrode to the liquid.

The offered intervals are from 6 to 10 mm. In addition, a light-receiving device is provided, capable of recording the characteristic spectral lines of radicals or ions formed during activation using the method of optical radiation spectroscopy (optical emission spectroscopy).

The direct action of an electric discharge on a liquid and the flow of current through it is also disclosed in the publication CN 109121278 A. The discharge used can also be an electric barrier discharge.

Publication WO 2017/192618 A1 describes a device and method for producing a plasma-activated aqueous chemotherapeutic agent. For this purpose, a discharge vessel is provided in which at least one hollow needle electrode is located, wherein the vessel has an electrically insulating lining inside. The electrodes are fixed on a rotating hollow shaft into which air is supplied. A barrier discharge occurs between the electrodes and the vessel wall. The liquid supplied to the vessel comes into close contact with the barrier discharge and is discharged in an activated state at the lower edge of the vessel.

The above methods allow obtaining plasma-activated aqueous liquids. It is also known that such activated liquids can be stored, at least for a limited time. Activated liquids have a wide range of action, and their effectiveness changes over time. This may be an uncertainty factor when using plasma-activated liquids.

Based on this, the objective of the invention is to improve the reproducibility of the success of treatment in the medical use of plasma-activated liquids.

The proposed device for supplying a medical instrument with plasma-activated liquid comprises a plasma generator and a plasma action device, by means of which the plasma created by the plasma generator is brought into contact with the liquid. The liquid can be continuously or in portions withdrawn through the outlet of the plasma action device and fed to the instrument. In this case, the liquid can be withdrawn into the instrument immediately or can be temporarily stored in a storage vessel for a certain period of time.

The device proposed in the invention also contains a sensor device and a control device. The sensor device is provided for recording at least one chemical or physical parameter of the liquid during and/or after exposure to plasma. The parameter recorded by the sensor device is used by the control device for controlling the characteristics of the plasma-activated liquid supplied to the tool. The control device has an input connected to the sensor device. At the output, the control device can be connected, for example, to a plasma generator for influencing the parameters of the plasma discharge. The control device is configured to control the plasma generator with respect to the amplitude factor or the shape of the curve of the current supplied by it or the voltage supplied by it. In addition, the control device can be configured to control the plasma generator additionally with respect to the voltage, current or power supplied by it.

Additionally, the control device may be connected to the plasma treatment device, pumps, valves or other control elements to influence the plasma treatment parameters. For example, the residence time of the liquid in or near the plasma. If the liquid is introduced into contact with the plasma in a compact (coherent) form, in the form of a thin film or in the form of drops, the control device may influence the flow rate of the liquid, the size of the liquid droplets, the thickness of the liquid layer and other similar parameters. As a supplement or alternative, the control device may be connected to the control elements of the storage vessel, such as, for example, valves or pumps, to influence the residence time of the activated liquid in the storage vessel.

The plasma generator preferably has a gas channel and at least one electrode in contact with the gas from the gas channel. This electrode can be an insulated electrode in order to supply the barrier discharge. It can also be an electrode with an electrically conductive surface in order to enable the direct transfer of electrons from the electrode into the plasma. A gas, in particular an inert gas such as argon, can be supplied into the gas channel. In this way, the gas can be ionized at the electrode, and thus a plasma can be formed, in particular a plasma jet in contact with the liquid. The liquid can be in electrical contact with another electrode. In this case, it is preferably a non-insulated electrode. In this case, the electrode has an electrically conductive surface, which enables the transfer of electrons from the liquid into the electrode and from the electrode into the liquid. The activation of the liquid by the plasma is preferably carried out by the action of the plasma jet on the liquid. The liquid can then form a compact body having a corresponding surface, for example a horizontal liquid surface. A plasma jet can also be injected into a liquid so that parts of the plasma rise in the liquid as bubbles. In addition, it is also possible to inject sprayed liquid into an argon plasma jet. However, other types of plasma, in particular air plasma, can also be used instead of an argon plasma jet. Plasma can be cold plasma or plasma whose gas temperature is "warm", i.e. exceeding the temperature of the human body.

In particular, a plasma generator with a non-insulated electrode, which allows current to flow through the liquid, is suitable for plasma activation of liquid.

As a result of the plasma treatment, agents, i.e. chemical compounds with different lifetimes and reactivities, are formed in the liquid, which are generally referred to as plasma-generated agents. Such plasma-generated agents may be hydronium ions, hydroxide ions, hydrogen peroxide and/or nitrite ions and/or nitrate ions and/or peroxynitrite and/or singlet oxygen and/or ozone and/or oxygen and/or superoxide radical ions and/or hydroxyl radicals and/or hydroperoxyl radicals and/or nitrogen oxides such as nitrogen monoxide and nitrogen dioxide. The sensor device provided for recording (determining) such agents may be a sensor device suitable for optical spectroscopy, such as ultraviolet light absorption spectroscopy, visible light absorption spectroscopy or infrared light absorption spectroscopy. As a supplement or alternative, the sensor device may be a device suitable for detecting phosphorescence, in particular phosphorescence in the near infrared region. As a supplement or alternative, the sensor device may be designed with the possibility of performing optical emission spectroscopy for UV light, visible light and/or near infrared light. As a supplement or alternative, the sensor device may be a device for electron spin resonance spectroscopy.

The subject of the invention is also a method for producing a plasma-activated liquid used for treatment, characterized in that by means of a plasma generator a plasma is created, into contact with which a liquid is introduced in a plasma action device, and this liquid is supplied to the instrument, during and/or after the action of the plasma on the liquid in the plasma action device by means of a sensor device at least one chemical or physical parameter of the liquid is recorded, and by means of a control device connected at the input to the sensor device and at the output to the plasma generator, the operation of the plasma generator is controlled in relation to the amplitude factor or the shape of the curve of the current it produces or the voltage it produces depending on the recorded parameter of the liquid for influencing the said parameter.

Other details of the preferred embodiments of the invention are discussed below in the description or in the drawings, which show:

Fig. 1 is a functional diagram illustrating the structural and functional elements of the installation proposed in the invention for supplying a medical element with plasma-activated liquid,

Fig. 2 - a plasma treatment device for obtaining plasma-treated liquids.

Fig. 1 shows a device 10 for supplying a medical instrument 11 with a plasma-activated liquid, with the aid of which it is possible to carry out treatment by at least one of various methods. The treatment methods are shown in Fig. 1 by functional blocks, wherein block 13 denotes the injection of a plasma-activated liquid under the tissue. Block 14 denotes the alternating treatment of the tissue, or the effect on the tissue, by plasma, for example argon plasma, and/or high-frequency current, as well as by plasma-activated liquid. Block 15 denotes the wetting or irrigation of the tissue with a plasma-activated liquid.

Instrument 11 is understood to mean any instrument capable of performing treatment using at least one of the above-mentioned methods, represented by blocks 13-15, as well as other instruments for other applications of plasma-activated liquid on a patient or biological tissue.

The device 10 comprises a treatment vessel 16 in which a liquid, such as a sodium chloride solution, Ringer's solution, lactated Ringer's solution or another liquid applied to the patient, is to be treated with plasma. The liquid comes from a storage vessel 17 connected to the treatment vessel 16 by means of a controlled pump 18. The pump 18 serves to supply liquid from the storage vessel 17 to the treatment vessel 16 under the control of a control device 19, as shown by arrows 20, 21. Additionally, the pump 18 can be designed, at least as an option, with the possibility of pumping liquid from the treatment vessel 16 back to the storage vessel 17, as shown by arrows 22, 23. The direction of supply and, if necessary, the performance of the pump 18 during its operation are set by the control device 19, as shown by arrow 24.

The processing vessel 16 may be a vessel in which the liquid F to be processed, as shown sketched in Fig. 2, is contained in the form of a compact (connected) liquid body with a substantially horizontal surface. At the same time, any other vessel in which it is possible to introduce liquid into contact with the plasma may serve as the processing vessel 16. Such vessels are, for example, irrigation vessels in which liquid can flow in the form of a drop curtain through the plasma or a layer of liquid can flow along the plasma, vessels with a spray device introducing liquid in sprayed form into the plasma, with centrifugal devices introducing liquid in the form of a thin film into contact with the plasma, or other similar vessels. The processing vessel 16 together with the plasma 30 (Fig. 2) created in it forms a plasma action device 25.

In addition, Fig. 1 shows various mixing devices, represented by the functional units 26-28 outlined by a broken line, of which the installation preferably includes at least one, and which serve to ensure a uniform distribution of the reactive agents formed in the processing vessel. This purpose can be served by a convector 26, which creates a convection current by acting on the liquid with heat or cold. Alternatively, a mixing device 27 can be provided, which serves to set the liquid F in motion in the processing vessel 16. The functional unit 28 is a gas swirler for introducing the liquid in the processing vessel into close contact with the plasma 30. Each of the devices represented by the functional units 26, 27, 28 can be located in or on the processing vessel 16 alone or in combination with one or more of the above-mentioned devices.

As shown in Fig. 2, a plasma applicator 29 is adjacent to the processing vessel 16, which is designed to generate plasma 30. For example, the plasma applicator 29 can be an argon-plasma applicator. It comprises a gas supply channel 31, through which an inert gas is supplied, for example nitrogen or a noble gas, such as argon or helium, or another gas suitable for generating plasma, for example a reactive gas, in particular an oxygen-containing gas. The gas channel 31 is connected to a gas source 32. The gas source, as shown in Fig. 1, can be made controllable and can be connected to a control device 19, capable of controlling the gas source with respect to the gas output time and/or with respect to the flow rate of the output gas, i.e. the amount of gas flow.

The plasma applicator also contains an electrode 33, preferably made non-insulated, i.e. having an electrically conductive surface, and in contact with the gas flow in the gas supply channel 31 or washed by this flow.

This electrode is connected to one pole of the plasma generator 34, the other pole of which is connected, for example, to the electrode 35 washed by the liquid F. The plasma generator is preferably a high-frequency generator, designed with the possibility of outputting a high-frequency voltage and a high-frequency current. The generator is preferably controllable with respect to the magnitude of the output voltage and/or the output power and/or the current and/or with respect to the shape of the curve, the modulation of the pulse duty cycle, the amplitude factor or other parameters. For this purpose, the plasma generator 34 can be connected to the control device 19 and can be controlled by it, as shown in Fig. 1.

The installation 10 also comprises a sensor device 36, intended and constructed to analyze the liquid F being processed with respect to the chemical agents formed therein. Such agents in the broadest sense are substances, as well as ions, radicals, molecular fragments, etc., formed as a result of the plasma processing of the liquid F. The sensor device 36 can be located outside the processing vessel 16, as shown schematically in Fig. 2, and can be supplied with liquid F from the processing vessel 16, for example by means of a circulation circuit 37.

Fig. 2 schematically shows a sensor device 36 for optical absorption spectroscopy. For this purpose, the sensor device 36 comprises a light-emitting device 38 and a light-receiving device 39. The light-emitting device 38 is designed, for example, with the possibility of emitting ultraviolet, visible and/or infrared light with a known spectral composition into the liquid F. The light-receiving device 39 is preferably designed with the possibility of recording the spectral composition of the ultraviolet, visible and/or infrared light that has passed through the liquid F. The control device 19 is designed with the possibility of determining the presence and concentration of selected agents based on the difference between the spectra of the light emitted by the light-emitting device 38 and the light received by the light-receiving device 39.

Instead of the sensor device 36 implementing the method of optical absorption spectroscopy, any other sensor device may also be provided, which is capable of registering the presence and/or concentration of one or more agents in the liquid. Such sensor devices may be emission spectroscopy devices (radiation spectroscopy) for ultraviolet, visible and/or infrared light. The sensor device may also be a phosphorescence registration device for ultraviolet, visible and/or infrared light, in particular for light in the near infrared region. In addition, the sensor device 36 may be a device for measuring the hydrogen index pH, in particular a single-rod measuring chain. The sensor device 36 may include one or more of the above-mentioned sensor devices.

The control device 19 can control the plasma generator 34 to regulate the concentration and/or composition of various agents in the liquid F. The control device 19 can control, for example, the current and/or voltage output by the plasma generator 34 in terms of power, magnitude, curve shape, amplitude factor, frequency, modulation, etc., in order to thereby control the plasma, and hence the formation of agents.

The processing vessel 16 can be connected directly to the tool 11 by means of a pump 40 for supplying it with plasma-activated liquid. As a possible variant, a storage vessel 41 can also be provided between the pump 40 and the tool 11, in which the plasma-activated liquid can be stored for a given or selectable time.

In addition to the connection of the sensor device with the circulation circuit 37 or as an alternative to such a connection, the sensor device 36 can be connected to the storage vessel 41. In the same way, the storage vessel 41 can be connected to its own sensor device, which is then connected in turn to the control device 19. By controlling the pump 40 and/or a pump not shown in the drawings, which can be arranged between the storage vessel 41 and the instrument 11, the control device 19 can set the storage duration of the plasma-treated liquid F. Since after the plasma treatment of the liquid F the concentration of the agents formed in the plasma-treated liquid decreases at different rates, the control device 19, by setting a certain storage duration, if necessary under the control of the sensor device 36, can deliver the plasma-treated liquid F in which, for example, short-lived agents have practically disappeared, but long-lived agents are contained in a high concentration. On the other hand, if the treatment requirement primarily requires short-lived agents, then the sensor device 36 can determine whether such agents have been produced in sufficient concentration to be supplied to the instrument 11 immediately. Furthermore, if necessary, the possibility can be provided for supplying liquid from the storage vessel 41 to the processing vessel 16 for deactivation (additional or subsequent activation). This possibility is shown in Fig. 1 by double-headed arrows 42, 43.

The described installation 10 and instrument 11 operate as follows: First, the storage vessel 17 is filled through the filling pipe 44 (Fig. 1) with the liquid to be activated, for example, a sodium chloride solution. Then the control device 19 activates the pump 18 and ensures the supply of liquid F into the processing vessel 16, for example, with filling the processing vessel 16 with liquid F. In addition, the control device 19 activates the plasma generator 34, and also, if necessary, the gas source 32, as a result of which the plasma applicator 29 creates a plasma 30, which acts on the liquid F (Fig. 2). The sensor device 36 is continuously in the active state or is activated at discrete intervals to record the quality of the liquid F, i.e. the quality of its plasma activation. In this case, the quality of the plasma activation is measured, in particular, by the concentration of the selected agent, for example, by the content of hydronium ions, hydroxyl ions, hydrogen peroxide, nitrite, nitrate, peroxynitrite, singlet oxygen, ozone, hydroxyperoxide, oxygen, superoxide radical ions, hydroxyl radicals and/or hydroperoxyl radicals. For recording such agents, the sensor device 36 is designed as a so-called single-rod measuring chain for measuring pH, as a spectroscope for analyzing the emitted light (infrared, visible and/or ultraviolet), as an absorption spectroscope (as shown in Fig. 2), as a phosphorescence sensor, for example for radiation with a wavelength of 1275 nm for the purpose of measuring singlet oxygen, or as a spectroscope for analysis using the electron spin resonance method. The sensor device 36 can also include several of the above-mentioned measuring devices.

Based on the concentration of the selected agent determined by the sensor device, the control device 19 can set, extend or shorten the duration of plasma treatment of the liquid, can regulate the parameters of the current or voltage supplied by the plasma generator 34 and/or can affect the flow rate of gas supplied from the gas source 32. As a supplement or alternative, the control device 19 can set or limit the duration of storage of the plasma-treated liquid in the storage vessel 41 and/or can control one or more devices 26-28.

The control device 19 may be designed to influence the quality of the liquid F in the context of one or more of the following relationships:

- impact on the strength of the plasma effect, i.e. on the electrical power converted in the plasma or other parameters, depending on the required pH value. At higher power, a lower pH value is achieved.

- setting the duration of plasma exposure to liquid depending on the required pH value. A lower pH value is achieved with a longer duration of exposure.

- setting the strength of the plasma effect, i.e. the electrical power converted in the plasma or other parameters, depending on the required ratio of hydrogen to nitrate.

- selection of the liquid to be processed depending on the required hydrogen to nitrate ratio. Liquids available for selection may be, for example, a NaCl solution and a phosphate buffer solution of NaCl.

In order to achieve the required quality of the liquid F, i.e. the required composition of the agents contained therein, the control device 19 can use the chemical and/or physical parameter(s) of the processed liquid F recorded by the sensor device 36 to control the operating mode of the plasma action device 25 or the plasma generator 34. When controlling the plasma generator, an effect is exerted on at least one parameter of the current and/or voltage produced by the plasma generator.

The invention provides for the creation of a device 10 for obtaining a plasma-activated liquid F with specified characteristics. The device 10 comprises a plasma action device 25 equipped with a plasma applicator 29, in which the liquid F is brought into contact with a gas plasma 30. A sensor device 36 is provided, which serves to analyze the composition of the plasma-treated liquid F at least with respect to the agent created by the plasma treatment. Based on the concentration of one or more agents recorded by the sensor device 36, the parameters for treating the liquid F in the plasma action device 25 can be set or changed. In this way, it is possible to obtain a plasma-treated liquid F with specified characteristics for treating a patient.

List of reference designations:

10 Installation for obtaining plasma-activated liquid

11 tool

12-15 functional blocks symbolizing treatment with plasma-activated liquid

16 processing vessel

17 storage vessel

18 pump

19 control device

20, 21 arrows indicating the direction of pump feed 18

22, 23 arrows indicating the optional direction of pump feed 18

24 arrow indicating pump control 18

25 plasma impact device

26 functional block - convector

27 functional block - mixing device

28 functional block gas swirl device

29 plasma applicator

30 plasma

31 gas supply channels

32 gas source

33 electrode

34 plasma generator

35 electrode

36 touch device

37 circulation circuit

38 light emitting device

39 light-receiving device

40 pump

41 storage vessels

42, 43 double-sided arrows

44 filling nozzle

Claims (23)

1. An installation (10) for supplying a medical instrument (11) with plasma-activated liquid, containing: - plasma generator (34) for creating plasma (30), - a plasma action device (25) designed with the possibility of introducing a liquid (F) located therein into contact with the plasma (30) and having an outlet for removing the liquid from the plasma action device (25) and feeding it to the tool (11), - a sensor device (36) for recording at least one chemical or physical parameter of the liquid (F) during and/or after the action of plasma on the liquid in the plasma action device (25), and - a control device (19) connected at the input to the sensor device (36) and at the output to the plasma generator (34) for controlling the plasma generator (34) depending on the registered parameter of the liquid (F), characterized in that the control device (19) is designed with the possibility of controlling the plasma generator (34) in relation to the amplitude factor or the shape of the curve of the current produced by it or the voltage produced by it. 2. The installation according to claim 1, characterized in that the plasma action device (25) comprises a plasma applicator (29) having a gas channel (31) and at least one electrode (33) in contact with the gas from the gas channel, as well as an electrode (35) in electrical contact with the liquid, wherein both electrodes are connected to a plasma generator (34). 3. An installation according to one of the previous points, characterized in that the output of the plasma action device (25) is connected to a storage vessel (41) connected to the instrument (11). 4. The installation according to item 3, characterized in that the control device (19) is connected to at least one control body for controlling the duration of the liquid (F) stay in the plasma action device (25). 5. An installation according to one of the previous points, characterized in that the control device (19) is designed with the possibility of controlling the plasma generator (34) additionally with respect to the voltage, current or power it produces. 6. The installation according to item 2, characterized in that the gas channel (31) is connected to a gas source (32), controlled in relation to the gas flow rate. 7. The installation according to item 6, characterized in that the control device (19) is connected to the gas source (32) to control the gas flow from it depending on the registered parameter. 8. An installation according to one of the preceding paragraphs, characterized in that the sensor device (36) is designed with the ability to record temperature and/or conductivity and/or acidity (pH value) and/or chemical composition and/or concentration of certain chemical compounds. 9. An installation according to one of the preceding paragraphs, characterized in that the sensor device (36) is designed with the possibility of recording the concentration in the plasma-activated liquid of agents created by the plasma in the form of hydroxonium ions (H ₃ O ⁺ ), and/or hydroxyl ions (OH ^- ), and/or hydrogen peroxide (H ₂ O ₂ ), and/or nitrite ions (NO ₂ ^- ), and/or nitrate ions (NO ₃ ^- ), and/or hydroxyl radicals (⋅OH). 10. An installation according to one of the preceding paragraphs, characterized in that the sensor device (36) is designed with the possibility of recording the concentration of agents created by plasma in the plasma-activated liquid (F) using spectroscopy, for example, spectroscopy of the absorption of electromagnetic radiation, in particular light, primarily visible light. 11. An installation according to one of the preceding paragraphs, characterized in that the sensor device (36) is designed with the possibility of recording the concentration in the plasma-activated liquid (F) of agents created by the plasma in the form of singlet oxygen ( ¹ O ₂ ), and/or ozone (O ₃ ), and/or oxygen (O ₂ ), and/or superoxide radical ions (O ₂ ^- ), and/or hydroperoxyl radicals (HOO⋅), and/or peroxynitrite ions (ONOO ^- ), and/or nitrogen oxides, such as, for example, nitrogen monoxide (NO) or nitrogen dioxide (NO ₂ ). 12. An installation according to one of the preceding paragraphs, characterized in that the sensor device (36) is designed with the possibility of recording the concentration of agents created by plasma in the plasma-activated liquid (F) by means of phosphorescence or electron spin resonance spectroscopy. 13. A method for obtaining a plasma-activated liquid used for treatment, characterized in that: - using a plasma generator (34) create plasma (30), - bring the liquid (F) into contact with the plasma (30) in the plasma action device (25) and feed the liquid to the instrument (11), - during and/or after the action of plasma on the liquid in the plasma action device (25), at least one chemical or physical parameter of the liquid (F) is recorded by means of a sensor device (36), - by means of a control device (19), connected at the input to the sensor device (36) and at the output to the plasma generator (34), the operation of the plasma generator (34) is controlled in relation to the amplitude factor or the shape of the curve of the current it produces or the voltage it produces depending on the registered parameter of the liquid (F) in order to influence the specified parameter. 14. The method according to claim 13, characterized in that the control device (19) additionally controls the duration of the liquid (F) stay in the plasma action device (25).

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