RU2820922C2 - Herbicide combination - Google Patents

Abstract

FIELD: agriculture.

SUBSTANCE: invention relates to agriculture, in particular to control of undesirable vegetation. Synergetic herbicide mixture for weed control in crops contains: (a) amicarbazone; (b) at least a photosystem II inhibitor selected from atrazine, diuron, ametrine, and (c) at least a third herbicide selected from isoxaflutole, clomazone, sulphentrazone, mesotrione, S-metolachlor, where said mixture is selected from: (i) a mixture of amicarbazone, isoxaflutole and atrazine; (iv) a mixture of amicarbazone, clomazone and diuron; (vii) a mixture of amicarbazone, S-metolachlor and atrazine; (viii) a mixture of amicarbazone, sulphenrazone and diurone; and (x) a mixture of amicarbazone, mesotrione and ametrine. Synergistic herbicidal mixture is used in a composition for controlling undesirable vegetation.

EFFECT: disclosed synergistic herbicide mixture and composition on its basis provide effective control of a wide range of weeds, help to control resistance to herbicides, reduce the applied dosage of herbicides, have a long residual effect.

12 cl, 11 tbl, 2 ex

Description

FIELD OF TECHNOLOGY TO WHICH THE INVENTION RELATES

The present invention relates to herbicide combinations for the control of harmful unwanted plants. The present invention more specifically relates to a synergistic combination of herbicides.

BACKGROUND OF THE ART

Weeds are unwanted plants that can cause significant crop yield losses. Farmers usually monitor these plants at the pre-planting stage as well as after planting. Modern herbicides are used to either control or suppress these unwanted plants in order to provide a greater proportion of nutrients to the crops planted.

Current practices include combining herbicides with different mechanisms of action, which provide a broader range of control and resistance management. However, currently known combinations are insufficient to control resistant and persistent weeds. Growers are increasingly faced with difficult situations involving weeds that cannot be controlled with herbicide alone.

Combinations of herbicides are used to control a wider range of weeds. However, a combination of herbicides may not always achieve the desired effect. The combination of herbicides can result in an additive effect or an antagonistic effect. It may also cause phytotoxicity to crops, making the combination undesirable. Therefore, agronomists must carefully select herbicides that can be combined to produce synergistic effects, provide weed control without causing phytotoxic effects on crops, and reduce the likelihood of herbicide-resistant weeds developing.

US8785351 discloses a combination containing bentazone, an ALS inhibitor and an ACC inhibitor. Sulfonylureas are listed as a long list of potential ALS inhibitors, while some PPO inhibitors are listed simply as a possible additional herbicide among an equally large number of herbicides. This disclosure is general and does not provide guidance regarding the combinations of the present invention.

Therefore, there is a need in the art for combinations that have advantageous properties, such as a herbicide combination that is synergistic, promotes resistance management, reduces the herbicide dosage applied, thereby causing minimal environmental damage, and a herbicide combination that has excellent residual properties. effects.

Therefore, embodiments of the present invention may help solve one or more of the above problems.

SUMMARY OF THE INVENTION

Therefore, in one aspect of the present invention, a herbicidal combination may be provided comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least one photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In another aspect, the present invention may provide a method for in-situ control of weeds, the method comprising applying to the site a herbicidal combination comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one aspect of the present invention, a herbicidal composition may be provided comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide;

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor; And

(d) at least one agrochemically acceptable excipient.

In yet another aspect of the present invention, there may be provided a method for increasing the yield of a crop, the method comprising applying to the crop a combination comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In another aspect, the present invention may provide a method for improving the health of a plant, the method comprising administering to a plant or growing area in which said plant grows or which is intended to grow said plant, a combination comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

DETAILED DESCRIPTION OF THE INVENTION

The term “herbicide” as used herein means an active ingredient that kills, controls or otherwise adversely affects the growth of weeds. As used herein, a "herbicidal effective amount" or a "vegetation control amount" is an amount of an active ingredient that produces a "herbicidal effect", that is, an effect causing adverse changes, which includes deviation from the natural development, destruction, regulation , drying out, slowing down. The terms “plants” and “vegetation” include, without limitation, germinating seeds, germinating seedlings, plants emerging from vegetative shoots, and existing vegetation. The term "locality" as used herein refers to the surrounding area of a desired crop for which weed control, typically selective weed control, is required. The habitat includes the surrounding area of the desired crop where weed infestation has either already occurred or has not yet occurred. The term “crop” will include a plurality of desired crop plants or a single crop plant growing in a location.

In any aspect or embodiment described herein below, the phrase “comprising” may be replaced by the phrase “consisting of” or “consisting essentially of” or “consisting essentially of.” In these aspects or embodiments, the described combination or composition includes, or contains, or consists of, or consists essentially of, or consists essentially of, the specific components cited herein, excluding other fungicides or insecticides or herbicides, or plant growth promoting agents or auxiliaries or excipients not specifically cited herein.

The term “synergy” can generally be defined as a combination of two elements in which the result from the use of this combination is greater than the sum of the results that these elements would provide separately. This is an unexpected result, achieved only by bringing the components into contact, and therefore cannot be predicted, implied or assumed. The term "plants" includes germinating seeds, shoots, germinating seedlings and existing vegetation, including roots and aerial parts, such as leaves, stems, flowers, fruits, offshoots, branches, roots and the like. The term "plant of agricultural interest" is to be understood as any type of plant intended for commercial consumption and may be an edible or non-edible type of plant, flowering or non-flowering plants, trees, herbs [plants with creeping rhizomes, herbaceous plants or herbs]. The term “weed” according to Lorenzi (2014) is any plant that grows where it is not desired while directly or indirectly interfering with crops of interest, causing a significant reduction in the overall productivity of those crops. The term "biotic factors" can be understood as the sum of all the effects caused by organisms in an ecosystem that determine the populations that form it, and in the present invention organisms are understood to mean weeds. The term "agrochemicals", also known as insecticides, pesticides, biocides, herbal medicines or phytosanitary products, is a general term for various chemicals used in agriculture.

The present inventors have surprisingly discovered that the effectiveness of a triazolinone herbicide is synergistically enhanced by the presence of at least another photosystem II inhibitor and a third non-specific herbicide.

Without being bound by any theory, the present inventors believe that the triazolinone herbicide inhibits protoporphyrinogen oxidase (PPG oxidase or Protox), an enzyme in chlorophyll and heme biosynthesis that catalyzes the oxidation of protoporphyrinogen IX (PPGIX) to protoporphyrin IX (PPIX). Inhibition of Protox results in the accumulation of PPIX, the first light-absorbing precursor of chlorophyll. Light absorption by PPIX appears to produce triplet-state PPIX, which reacts with ground-state oxygen to produce singlet oxygen. Both triplet PPIX and singlet oxygen can abstract hydrogen from unsaturated lipids to form a lipid radical and initiate a chain reaction of lipid peroxidation. Lipids and proteins are attacked and oxidized, resulting in loss of chlorophyll and carotenoids and disruption of membrane permeability, which promotes rapid desiccation and breakdown of cells and cellular organelles (Duke 1991).

This activity is synergistically enhanced by the presence, in addition to the triazolone herbicide, of at least two other herbicides, at least one of which leads to the formation of triplet chlorophyll and singlet oxygen, thereby enhancing the first route of herbicidal action, while the third herbicide is non-specific and enhances the mechanism of herbicidal activity with the formation of singlet oxygen at least in another way.

Thus, the second herbicide of the combination is a photosystem II inhibitor that inhibits photosynthesis by binding to the QB binding niche of the photosystem II complex D1 protein in the thylakoid membranes of chloroplasts. The inability to re-oxidize QA promotes the formation of triplet-state chlorophyll, which reacts with ground-state oxygen to form singlet oxygen. Both triplet chlorophyll and singlet oxygen can abstract hydrogen from unsaturated lipids to form a lipid radical and initiate a chain reaction of lipid peroxidation, thereby simultaneously synergistically enhancing the activity of the triazolinone herbicide. Lipids and proteins are attacked and oxidized, resulting in loss of chlorophyll and carotenoids and disruption of membrane permeability, which promotes rapid desiccation and breakdown of cells and cellular organelles.

The third effective herbicide in the combination of the present invention is a 4-HPPD inhibitor, a bleach inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

Therefore, in one aspect of the present invention there is provided a herbicidal combination comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor as a second herbicide selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide; urea herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, triazolone herbicides also exhibit ALS inhibitory activity that is further synergistically enhanced if the second herbicide is a photosystem II inhibitor and if the third herbicide is an additional ALS inhibitor.

In one embodiment, the triazolone herbicide is an amicarbazone.

In one embodiment, the triazolone herbicide is bencarbazone.

In one embodiment, the triazolone herbicide is carfentrazone.

In one embodiment, the triazolone herbicide is flucarbazone.

In one embodiment, the triazolone herbicide is ipfencarbazone.

In one embodiment, the triazolone herbicide is a sulfentrazone.

In accordance with one embodiment, the present invention provides a herbicidal combination comprising:

(a) at least one triazolone-based herbicide;

(b) at least a photosystem II inhibitor selected from the group consisting of

(i) a phenylcarbamate herbicide;

(ii) a triazine herbicide;

(iii) a triazinone herbicide;

(iv) a uracil-based herbicide;

(v) a benthiadiazole herbicide;

(vi) a nitrile-based herbicide and

(vii) a urea herbicide;

And

(c) at least the third herbicide is selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the herbicide combinations of the present invention contain one herbicide from these three classes of herbicides.

In one embodiment, the herbicidal combinations of the present invention further comprise at least one antidote.

In one embodiment, crop safeners for herbicides can be classified by chemical composition into the following groups:

1) naphthopyranones;

2) dichloroacetamides;

3) dichloromethyl acetals and ketals; 4) oxime ethers;

5) derivatives of 2,4-disubstituted 5-thiazolecarboxylates;

6) substituted phenylpyrimidines;

7) substituted phenylpyrazoles;

8) esters of quinolyloxycarboxylic acid;

9) thiolcarbamates;

10) diaryl ketones;

11) haloalkylaryl sulfones.

In one embodiment, the antidote may be selected from the group consisting of isoxadifen ethyl, cloquintocet mexyl, mefenpyr diethyl, naphthalene anhydride, oxabetrinyl, benzenesulfonamide, N-(aminocarbonyl)-2-chlorobenzenesulfonamide (2-CBSU), daimuron, dichloroacetamide, Dyciconeon, Fenklorazol-Etil, Fenklomi, Fluxophynim, Dichloracetamital Antidotes (for example, AD-67, Benksakor, Dichlormide and Furilazole), Naftopiranon, Naphtalin Angidride (Na), Oxim, Phoenylpirimin, phenylmochevine, phenylpirazor-based compounds Taline anhydride, qiumetricin, flurazole, dimepiperate, methoxyphenone, cloquintocet-mexyl (CGA-185072), 1-dichloroacetylhexahydro-3,3,8α-trimethylpyrrolo[1,2-α]pyrimidin-6-(2H-one) (BAS-145138), dichloromethyl- 1,3-dioxolane (MG-191), quinolinyloxyacetate compounds, or agriculturally acceptable salts, esters, or mixtures thereof.

In another embodiment, the present invention provides a herbicidal composition comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of

(i) a phenylcarbamate herbicide;

(ii) a triazine herbicide;

(iii) a triazinone herbicide;

(iv) a uracil-based herbicide;

(v) a benthiadiazole herbicide;

(vi) a nitrile-based herbicide and

(vii) a urea herbicide;

And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor; And

(d) at least one agrochemically acceptable excipient.

In another aspect, the present invention may provide a method for controlling weeds at a site, the method comprising applying a combination of the present invention to a site.

Thus, in this aspect, the present invention may provide a method for in-situ control of weeds, the method comprising in-situ application of a combination comprising:

(a) at least one triazolone-based herbicide;

(b) at least a photosystem II inhibitor selected from the group consisting of

(i) a phenylcarbamate herbicide;

(ii) a triazine herbicide;

(iii) a triazinone herbicide;

(iv) a uracil-based herbicide;

(v) a benthiadiazole herbicide;

(vi) a nitrile-based herbicide and

(vii) a urea herbicide;

And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In another aspect, the present invention provides a method for increasing the yield of a crop by using any combination of the present invention.

In yet another aspect of the present invention, there may be provided a method for increasing the yield of a crop by using a combination comprising:

(a) at least one triazolone-based herbicide;

(b) at least a photosystem II inhibitor selected from the group consisting of

(i) a phenylcarbamate herbicide;

(ii) a triazine herbicide;

(iii) a triazinone herbicide;

(iv) a uracil-based herbicide;

(v) a benthiadiazole herbicide;

(vi) a nitrile-based herbicide and

(vii) a urea herbicide;

And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In another aspect, the present invention may provide a method for improving plant health using any combination of the present invention.

Another aspect of the present invention may provide a method for improving the health of a plant, the method comprising applying to a plant location a combination comprising:

(a) at least one triazolone-based herbicide;

(b) at least a photosystem II inhibitor selected from the group consisting of

(i) a phenylcarbamate herbicide;

(ii) a triazine herbicide;

(iii) a triazinone herbicide;

(iv) a uracil-based herbicide;

(v) a benthiadiazole herbicide;

(vi) a nitrile herbicide and

(vii) a urea herbicide;

And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the herbicide combinations of the present invention contain one herbicide from these three classes of herbicides.

In one embodiment, the photosystem II inhibitor is a phenylcarbamate herbicide.

In one embodiment, the phenylcarbamate herbicide is selected from the group consisting of barban, BCPC, carbasulam, carbetamide, CEPC, chlorbufam, chlorpropham, CPPC, desmedipham, phenizopham, phenmedipham, phenmedipham-ethyl, propham, and swep.

In one embodiment, the phenylcarbamate herbicide is selected from the group consisting of chlorpropham, desmedipham, phenmedipham and phenmedipham-ethyl.

In one embodiment, the phenylcarbamate herbicide is chlorpropham.

In one embodiment, the phenylcarbamate herbicide is desmedipham.

In one embodiment, the phenylcarbamate herbicide is phenmedipham.

In one embodiment, the phenylcarbamate herbicide is phenmedipham-ethyl.

In one embodiment, the photosystem II inhibitor is a triazine herbicide.

In one embodiment, the triazine herbicide is selected from the group consisting of dipropetrin, fucaojing, trihydroxytriazine, atrazine, chlorazine, cyanazine, cyprazine, eglinzine, ipazine, mesoprazine, procyazine, proglinazine, propazine, sebutylazine, simazine, terbuthylazine, triethazine, lama, triaziflam, atratone, metomethron, promethone, secbumetone, simetone, terbumetone, ametrine, aziprothrine, cyanathrine, desmethrin, dimethamethrin, methoprothrine, promethrine, symethrine and terbutryne.

In one embodiment, the triazine herbicide is atrazine.

In one embodiment, the triazine herbicide is ametrine.

In one embodiment, the photosystem II inhibitor is a triazinone herbicide.

In one embodiment, the triazinone herbicide is selected from the group consisting of ametridione, amibuzine, etiosine, hexazinone, isomethiosine, metamitron, metribuzine and trifludimoxazine.

In one embodiment, the triazinone herbicide is hexazinone.

In one embodiment, the triazinone herbicide is metamitron.

In one embodiment, the triazinone herbicide is metribuzin.

In one embodiment, the photosystem II inhibitor is a uracil-based herbicide.

In one embodiment, the uracil-based herbicide is selected from the group consisting of benzfendizone, bromacil, butafenacil, flupropacil, isocyl, lenacyl, saflufenacil, terbacil and thiaphenacyl.

In one embodiment, the uracil-based herbicide is bromacil.

In one embodiment, the uracil-based herbicide is saflufenacil.

In one embodiment, the photosystem II inhibitor is a benzothiazole herbicide or a benzothiadiazole herbicide.

In one embodiment, the benzothiazole herbicide is selected from the group consisting of benazoline, benzthiazuron, fentiaprop, mefenacet and metabenzthiazuron.

In one embodiment, the photosystem II inhibitor is a benzothiadiazole herbicide.

In one embodiment, the benzothiadiazole herbicide is bentazone or sodium bentazone.

In one embodiment, the photosystem II inhibitor is a nitrile-based herbicide.

In one embodiment, the nitrile herbicide is selected from the group consisting of bromobonil, bromoxynil, chloroxynil, cyclopyranil, dichlobenil, iodobenil, ioxynil and pyraclonil.

In one embodiment, the nitrile herbicide is bromoxynil.

In one embodiment, the photosystem II inhibitor is a urea-based herbicide.

In one embodiment, the urea herbicide is a phenylurea herbicide.

In one embodiment, the phenylurea herbicide is selected from the group consisting of anisuron, buturon, chlorbromuron, chloreturon, chlorotoluron, chloroxuron, daimuron, difenoxuron, dimefuron, diuron, fenuron, fluometuron, fluothiuron, isoproturon, linuron, metyruon, methyldimuron, , metobromuron, methoxuron, monolinuron, monuron, neburon, parafluron, phenobenzuron, siduron, tetrafluron and thidiazuron.

In one embodiment, the phenylurea herbicide is diuron.

In one embodiment, the phenylurea herbicide is linuron.

In one embodiment, the photosystem II inhibitor is selected from the group consisting of chlorpropham, desmedipham, phenmedipham, phenmedipham-ethyl, atrazine, hexazinone, metamitron, metribuzin, bromacil, saflufenacil, bentazone, bentazone sodium, bromoxynil, diuron, and linuron.

In one embodiment, the third herbicide is selected from a 4-HPPD inhibitor, a bleach inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the 4-HPPD inhibitor is selected from the group consisting of isoxazole, pyrazolone and triketone or callistemon herbicides.

In one embodiment, the 4-HPPD inhibitor is an isoxazole-based herbicide.

In one embodiment, the 4-HPPD inhibitor is a pyrazolone-based herbicide.

In one embodiment, the 4-HPPD inhibitor is a triketone-based herbicide.

In one embodiment, the 4-HPPD inhibitor is a callistemon-based herbicide.

In one embodiment, the 4-HPPD inhibitor is selected from benzobicyclone, benzophenap, bicyclopyrone, fenquinotrione, isoxachlortole, isoxaflutole, mesotrione, pyrasulfotole, pyrazolinate, pyrazoxifene, sulcotrione, tefuryltrione, tembotrione, tolpyralate, topramesone.

In one embodiment, the 4-HPPD inhibitor is phenquinotrione.

In one embodiment, the 4-HPPD inhibitor is mesotrione.

In one embodiment, the 4-HPPD inhibitor is sulcotrione.

In one embodiment, the 4-HPPD inhibitor is tembotrione.

In one embodiment, the 4-HPPD inhibitor is topramesone.

In one embodiment, the PPO inhibitor is selected from diphenyl ether, N-phenylphthalimide, phenylpyrazole oxadiazole, thiadiazole, triazolinone, oxazolidinedione, and pyrimidinedione herbicides.

In one embodiment, the PPO inhibitor is a diphenyl ether.

In one embodiment, the PPO inhibitor is N-phenylphthalimide.

In one embodiment, the PPO inhibitor is an aryl triazoinone.

In one embodiment, the PPO inhibitor is a pyrimidinedione.

In one embodiment, the PPO inhibitor is selected from acifluorfen, fomesafen, lactofen, flumiclorac, flumioxazin, sulfentrazone, carfentrazone, flutiacet-ethyl and saflufenacil, azaphenidine, benzfendizone, bifenox, butafenacil, carfentrazone, carfentrazone-ethyl, chlomethoxifene, idon-ethyl, fluazolate, flufenpyr-ethyl, flumiclorac-pentyl, fluoroglycophen-ethyl, flutiacet-methyl, fomesafen, halosafen, lactofen, oxadiargyl, oxadiazone, oxyfluorfen, pentoxazone, profluazole, pyraclonil, pyraflufen-ethyl, saflufenacil, trifludimoxazine, a and tiafenacil.

In one embodiment, the microtubule assembly inhibitor is selected from benzamide, benzoic acid, dinitroaniline and pyridine herbicides.

In another embodiment, the microtubule assembly inhibitor is selected from benzamide, benzoic acid, dinitroaniline, amiprophos phosphoamidate and pyridine herbicides.

In one embodiment, the microtubule assembly inhibitor is selected from dinitroaniline, for example, benfluralin, butralin, dinitramine, benfluralin, butralin, dinitramine, trifluralin, propyzamide, DCPA, pendimethalin, ethalfluralin, oryzalin, trifluralin, prodiamine, dithiopyr, thiazopyr, or methylbutamiphos.

In another embodiment, the cellulose biosynthesis inhibitor is selected from alkylazine, benzamide, and nitrilotriazolocarboxamide herbicides.

In one embodiment, the cellulose biosynthesis inhibitor is selected from dichlobenil, chlorothiamide, indaziflam, isoxaben, dichlobenil and flupoxam.

In one embodiment, the cell division inhibitor is selected from chloroacetamide, acetamide, hydroxyacetamide, and tetrazolinone herbicides.

In one embodiment, the cell division inhibitor is selected from acetochlor, alachlor, butachlor, dimethachlor, dimethenamid, metazachlor, metolachlor, S-metolachlor, petoxamide, pretilachlor, propisochlor, tenylchlor, diphenamide, napropamide, D-napropamide, napropamide-M, naproanilide, phenacet , mefenacet, phentrazamide, propachlor, anilofos, cafenstrol, piperophos, DSMA and MSMA.

In one embodiment, the discoloration inhibitor is selected from triazoles, triketones, isoxazoles, pyrazole, pyridazinone, pyridinecarboxamide, isoxazolidinone, urea, amitrol diphenyl ether, mesotrione, sulcotrione, isoxazoles, isoxachlortol, isoxaflutole, benzophenap, pyrazolinate, pyrazoxifene, pyridazinone, she, pyridinecarboxamide, diflufenican, picolinafen, isoxazolidinone, clomazone, fluometuron, aclonifen, beflubutamide, fluridone, flurochloridone, flurtamone, bromobutide, (chloro)flurenol, cinmethylin, cumyluron, dazomet, dimron, methyldimuron, etobenzanide, fosamine, indanophane, , oxaziclomefone, oleic acid, pelargonic acid and pyributicarb.

In one embodiment, the ALS inhibitor is selected from the group consisting of:

(i) an imidazolinone-based herbicide;

(ii) a sulfonylaminocarbonyltriazolinone herbicide;

(iii) a sulfonylurea herbicide;

(iv) a pyrazole-based herbicide;

(v) a triazolepyramidine herbicide and

(vi) a triazolone herbicide;

In one embodiment, the ALS inhibitor herbicide is an imidazolinone herbicide.

In one embodiment, the imidazolinone herbicide is selected from the group consisting of imazamethabenz, imazamox, imazapic, imazapyr, imazaquin and imazethapyr.

In one embodiment, the imidazolinone herbicide is imazamox.

In one embodiment, the imidazolinone herbicide is imazapic.

In one embodiment, the imidazolinone herbicide is imazapyr.

In one embodiment, the imidazolinone herbicide is imazethapyr.

In one embodiment, the ALS inhibitor is a triazolone herbicide.

In one embodiment, the triazolone herbicide is selected from the group consisting of amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone, and thiencarbazone.

In one embodiment, the triazolone herbicide is carfentrazone.

In one embodiment, the triazolone herbicide is flucarbazone.

In one embodiment, the triazolone herbicide is a sulfentrazone.

In one embodiment, the triazolone herbicide is an amicarbazone.

In one embodiment, if the selected ALS inhibitor is a triazolone herbicide, the combinations of the present invention may thus contain at least two triazolone herbicides that are not the same.

Therefore, in one embodiment, if the triazolone herbicide is amicarbazone, the ALS inhibitor selected is a triazolone herbicide other than amicarbazone.

In one embodiment, the ALS inhibitor herbicide is a sulfonylaminocarbonyl triazolinone herbicide.

In one embodiment, the sulfonylaminocarbonyltriazolinone herbicide is flucarbazone.

In one embodiment, the sulfonylaminocarbonyltriazolinone herbicide is flucarbazone sodium.

In one embodiment, the ALS inhibitor herbicide is a sulfonylurea herbicide.

In one embodiment, the sulfonylurea herbicide is selected from the group consisting of amidosulfuron, azimsulfuron, bensulfuron, chlorimuron, cyclosulfamuron, ethoxysulfuron, flazasulfuron, flucetosulfuron, flupyrsulfuron, foramsulfuron, halosulfuron, imazosulfuron, mesosulfuron, metazosulfuron, methiopyr isulfuron, monosulfuron, nicosulfuron, orthosulfamuron, oxasulfuron, primisulfuron, propyrisulfuron, pyrazosulfuron, rimsulfuron, sulfometuron, sulfosulfuron, trifloxysulfuron, zoomihuanglong, chlorsulfuron, cinosulfuron, etamethsulfuron, iodosulfuron, iofensulfuron, metsulfuron, prosulfuron, thifensulfuron, triasulfuron, , triflusulfuron and tritosulfuron.

In one embodiment, the sulfonylurea herbicide is bensulfuron.

In one embodiment, the sulfonylurea herbicide is halosulfuron.

In one embodiment, the sulfonylurea herbicide is pyrazosulfuron.

In one embodiment, the sulfonylurea herbicide is pyrazosulfuron-ethyl.

In one embodiment, the sulfonylurea herbicide is sulfosulfuron.

In one embodiment, the sulfonylurea herbicide is trifloxysulfuron.

In one embodiment, the sulfonylurea herbicide is metsulfuron.

In one embodiment, the sulfonylurea herbicide is flazasulfuron.

In one embodiment, the ALS inhibitor herbicide is a pyrazole herbicide.

In one embodiment, the pyrazole herbicide is selected from the group consisting of azimsulfuron, cyclopyranil, difenzoquat, halosulfuron, flazasulfuron, metazachlor, metazosulfuron, pyrazosulfuron, pyrazosulfuron-ethyl, pyraclonil, pyroxasulfone, benzophenap, pyrasulfotole, pyrazolinate, pyrazoxyphene, tolpyralate, Ramaison, fluazolate, nipyraclofen, pinoxaden and pyraflufen.

In one embodiment, the pyrazole herbicide is metazachlor.

In one embodiment, the pyrazole herbicide is pinoxaden.

In one embodiment, the pyrazole herbicide is pyraflufen.

In one embodiment, the ALS inhibitor herbicide is a triazolopyrimidine herbicide.

In one embodiment, the triazolopyrimidine herbicide is selected from the group consisting of chloransulam, diclosulam, florasulam, flumetsulam, methosulam, penoxsulam and pyroxsulam.

In one embodiment, the triazolopyrimidine herbicide is diclosulam.

In one embodiment, the triazolopyrimidine herbicide is penoxulam.

In one embodiment, the ALS inhibitor herbicide is selected from the group consisting of imazamox, imazapic, imazapyr, imazethapyr, carfentrazone, flucarbazone, sulfentrazone, flucarbazone, amicarbazone, flucarbazone sodium, bensulfuron, halosulfuron, pyrazosulfuron, pyrazosulfuron-ethyl, flazasulfuron, sulfosulfuron, trifloxysulfuron, metsulfuron, metazachlor, pinoxaden, pyraflufen, diclosulam and penoxsulam.

In one embodiment, the triazolone herbicide, the photosystem II inhibitor, and the third herbicide are not the same. In this embodiment, the three herbicides are selected such that the selected herbicides are different from each other.

In one embodiment, the combinations of the present invention contain at least three different herbicides.

In one embodiment, the combinations of the present invention contain only three different herbicides disclosed herein. In this embodiment, no other fungicide, herbicide, insecticide or any other agrochemical is present in the combinations.

In one embodiment, the present invention provides preferred combinations, compositions and methods of using them. The methods of the present invention include a method of controlling weeds at a site by applying a combination or composition to a site, a method of increasing crop yield by applying a combination or composition, or a method of improving plant health by applying a combination or composition to a site. The embodiments presented herein describe preferred embodiments of all of these possible combinations, compositions, and methods of the present invention.

In accordance with one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) a phenylcarbamate herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) a triazine herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) a triazinone herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) uracil-based herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) benthiadiazole herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) nitrile-based herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) urea herbicide;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In accordance with one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) chlorpropham;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) desmediphs;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) phenmedipham;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) phenmedipham-ethyl;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) atrazine;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) ametrine;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) hexazinone;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) metamitron;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) metribuzin;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) bromacil;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) saflufenacil;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) bromoxynil;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) diuron;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) linuron;

(iii) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the herbicidal combination is preferably selected from

(i) amicarbazone + isoxaflutole + ametrine/diuron/atrazine;

(ii) amicarbazone + clomazone + diuron;

(iii) amicarbazone + S-metolachlor + ametrine/diuron/atrazine;

(iv) amicarbazone + sulfentrazone + ametrine/diuron;

(v) amicarbazone + halosulfuron-methyl + diuron;

(vi) amicarbazone + imazapic + ametrine/diuron;

(vii) amicarbazone + sodium trifloxysulfuron + diuron;

(viii) amicarbazone + pendimethalin + ametrine/diuron;

(ix) amicarbazone + napropamide + ametrine/diuron and

(x) amicarbazone + D-napropamide + ametrine/diuron;

(xi) amicarbazone + mesotrione + ametrine/diuron/atrazine;

(xii) amicarbazone + tembotrione + ametrine/diuron/atrazine and

(xiii) amicarbazone + indaziflam + ametrine/diuron.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) at least a photosystem II inhibitor; and

(iii) flumioxazin.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) propisochlor;

(iii) terbutylazine.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) isoxaflutole;

(iii) atrazine.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) clomazone;

(iii) diuron.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) sulfentrazone;

(iii) diuron.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) S-metolachlor;

(iii) atrazine.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) mesotrione;

(iii) ametrine.

In one embodiment, the present invention provides a herbicidal combination comprising:

(i) amicarbazone;

(ii) metribuzin;

(iii) pyrazosulfuron-ethyl.

In one embodiment, each individual row shown in the table below represents combinations in one embodiment of the present invention.

In one embodiment, the present invention may provide a combination containing three herbicides, as indicated in the table above.

In one embodiment, the present invention may provide a composition containing three herbicides, as specified in the table above, and at least one agrochemically acceptable excipient.

Such combinations can be applied to the weed site in a herbicidally effective amount.

In one embodiment, at least another active ingredient may be combined in the combination of the present invention, such as an active ingredient selected, without limitation, from a herbicide, insecticide, fungicide, biological agent, plant growth promoter, fertilizer, or combinations thereof.

Thus, in one embodiment, another herbicide can be combined in the combination of the present invention. Exemplary herbicides that may be combined in the combinations of the present invention may be selected, without limitation, from herbicides belonging to the classes of EPSP synthase inhibitors, synthetic auxins, auxin transport inhibitors, glutamate synthase inhibitors, HPPD inhibitors, lipid synthesis inhibitors, long-chain inhibitors. fatty acids, as well as herbicides with unknown mechanisms of action. Such herbicides include, but are not limited to, topramesone, orthosulfamuron, pinoxaden, metamifop, pyrimisulfan, tembotrione, thiencarbazone-methyl, flucetosulfuron, aminopyralide, pyrasulfotol, saflufenacil, pyroxulam, pyroxasulfone, pyraclonil, indaziflam, fenquinotrione, florpyrauxifene-benzyl, l, cinmethylin, sodium lancotrione, bixlozone, trifludimoxazine, cyclopyrimorate, methiozoline, aminocyclopyrachlor, metazosulfuron, ipfencarbazone, phenoxasulfone, bicyclopyrone, triafamone, halauxifen-methyl, tolpiralate or combinations thereof.

In one embodiment, the total amount of triazolone herbicide in the composition ranges from 0.1 to 99% by weight, preferably from 0.2 to 90% by weight.

In one embodiment, the triazolone herbicide is applied in an amount ranging from 50 g to 1000 g a. i./ha.

In one embodiment, the triazolone herbicide is applied in an amount ranging from 50 g to 500 g a. i./ha.

In one embodiment, the total amount of photosystem II inhibitor in the composition may range from 0.1 to 99% by weight, preferably from 0.2 to 90% by weight.

In one embodiment, the total amount of ALS inhibitor in the composition may range from 0.1 to 99% by weight.

In one embodiment, the total amount of chlorophyll and heme biosynthesis inhibitor in the composition may range from 0.1 to 99% by weight.

In one embodiment, the herbicides included in the combination of the present invention can be mixed in a ratio of (1-80) : (1-80) : (1-80) of the three herbicides, respectively.

The herbicidal combination of the present invention can be used against target weeds among crops such as corn, rice, wheat, barley, rye, oats, sorghum, cotton, soybeans, peanuts, buckwheat, beets, rapeseed, sunflower, sugarcane, tobacco etc.; among vegetable crops: nightshade vegetable crops, such as eggplant, tomato, clove pepper, pepper, potato, etc., pumpkin vegetable crops, such as cucumber, pumpkin, zucchini, watermelon, melon, pumpkin, etc., vegetable crops of the cruciferous family, such as radishes, white turnips, horseradish, kohlrabi, Chinese cabbage, cabbage, Sarepta mustard, broccoli, cauliflower, etc., vegetable crops of the Asteraceae family, such as burdock, chrysanthemum, artichoke, lettuce -lettuce, etc., vegetable crops of the lily family, such as green onions, onions, garlic and asparagus, vegetable crops of the Umbelliferae family, such as carrots, parsley, celery, parsnips, etc., vegetable crops of the gonoceae family, such as spinach, chard, etc., vegetables of the Lamiaceae family, such as Perilla frutescens, mint, basil, etc., strawberries, sweet potatoes, Dioscorea japonica, colocasia, etc., flowers, ornamental foliage plants, lawn grasses, fruit plants: pome fruit plants such as apple, pear, quince, etc., stone fruit plants with fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry, apricot, plum, etc. etc., citrus crops such as orange, lemon, lime, grapefruit, etc., nut crops such as chestnuts, walnuts, hazelnuts, almonds, pistachios, cashews, macadamia, etc., berry crops such such as blueberries, cranberries, blackberries, raspberries, etc., grapes, persimmons, olive trees, plums, banana trees, coffee trees, date palms, coconut trees, etc., trees other than fruit trees; tea plant, mulberry, flowering plants, trees such as ash, birch, dogwood, eucalyptus, ginkgo biloba, lilac, maple, oak, poplar, European crimson, Liquidambar formosana, sycamore, zelkova, thuja, fir, hemlock, juniper, pine, spruce and Taxus cuspidate, etc.

In one preferred embodiment, the agricultural crop plant is selected from the group consisting of cereals, rice, maize, sorghum, sugarcane, cotton, canola, turf, cereal crops, barley, potatoes, sweet potatoes, sunflowers, rye, oat varieties, wheat , corn, soybeans, sugar beets, tobacco, safflower, tomato, alfalfa, pineapple and cassava.

In one embodiment, the composition of the present invention may contain agriculturally acceptable auxiliaries, carriers, diluents, emulsifiers, fillers, antifoams, thickeners, freeze point depressants, freeze aids, etc. The compositions can be either solid or liquid. They may be solids, such as, for example, dusty powders, granules, water-dispersible granules, microcapsules or wettable powders, or liquids, such as, for example, emulsifiable concentrates, solutions, emulsions or suspensions, ZC formulations. They can also be supplied as a pre-mix or tank mix.

Agriculturally suitable adjuvants and carriers may include, but are not limited to, crop oil excipient concentrate; methylated seed oils, emulsified methylated seed oils, nonylphenol ethoxylate; benzylcocoalkyldimethyl quaternary ammonium salt; a mixture of petroleum hydrocarbons, alkyl esters, organic acids and anionic surfactants; C9-C11 alkyl polyglycoside; phosphated alcohol ethoxylate; natural primary (C12-C16) alcohol ethoxylate; di-sec-butylphenol block copolymer EO-PO; methyl-terminated polysiloxane; nonylphenol ethoxylate, urea ammonium nitrate; tridecyl (synthetic) alcohol ethoxylate (8EO); tallow amine ethoxylate; dioleate-99 PEG(400), alkyl sulfates such as diethanolammonium lauryl sulfate; alkylaryl sulfonate salts such as calcium dodecylbenzenesulfonate; alkylphenol and alkylene oxide addition products such as nonylphenol C ₁₈ ethoxylate; alcohol and alkylene oxide addition products such as C ₁₆ tridecyl alcohol ethoxylate; soaps such as sodium stearate; alkyl naphthalene sulfonate salts such as sodium dibutyl naphthalene sulfonate; dialkyl esters of sulfosuccinate salts such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters such as sorbitol oleate; quaternary amines such as lauryltrimethylammonium chloride; polyethylene glycol fatty acid esters such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; salts of mono- and dialkyl phosphate esters; vegetable or seed oils such as soybean oil, canola/canola seed oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cottonseed oil, flaxseed oil, palm oil, peanut oil, safflower oil, sesame oil oil, tung oil, etc.; and esters of the above vegetable oils, and in certain embodiments, methyl esters.

Suitable liquid carriers that can be used in the composition of the present invention may include water or organic solvents. Organic solvents include, but are not limited to, petroleum fractions or hydrocarbons such as mineral oil, aromatic solvents, paraffinic oils and the like; vegetable oils such as soybean oil, canola oil, olive oil, castor oil, sunflower seed oil, coconut oil, corn oil, cotton seed oil, flaxseed oil, palm oil, peanut oil, safflower oil, sesame oil, tung oil, etc. .P.; esters of the above vegetable oils; esters of monoalcohols or dibasic, tribasic or other lower polyhydric alcohols (containing 4-6 hydroxy), such as 2-ethylhexyl stearate, n-butyl oleate, isopropyl myristate, propylene glycol dioleate, dioctyl succinate, dibutyl adipate, dioctyl phthalate and the like; esters of mono-, di- and polycarboxylic acids, etc. Organic solvents include, but are not limited to, toluene, xylene, ligroin, oil crop aid, acetone, methyl ethyl ketone, cyclohexanone, trichlorethylene, perchlorethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol monomethyl ether and diethylene glycol monomethyl ether, methyl alcohol, ethyl alcohol, isopropyl alcohol , amyl alcohol, ethylene glycol, propylene glycol, glycerin, N-methyl-2-pyrrolidinone, N,N-dimethylalkylamides, dimethyl sulfoxide.

Solid carriers that may be used in the composition of the present invention may include, without limitation, attapulgite, pyrophyllite clay, silica, kaolin clay, diatomaceous earth, chalk, diatomaceous earth, lime, calcium carbonate, bentonite clay, Fuller's earth, talc, cotton seed husks , wheat flour, soy flour, pumice, wood flour, walnut shell flour, lignin, cellulose, etc.

Said compositions can be prepared in a generally known manner, for example by mixing the active ingredients with at least one conventional dry diluent. In accordance with the present invention, the combination may be the composition itself, with the final composition used usually being prepared by mixing the compounds of interest and the carrier, and, if necessary, by adding a surfactant and/or other formulation auxiliary, such as dry thinner, and by giving the mixture the required shape.

In accordance with the present invention, the following form of compositions can be used: encapsulated suspension, dispersible concentrate, emulsifiable concentrate, water-in-oil emulsion, oil-in-water emulsion, microemulsion, concentrated suspension, suspension-emulsion, soluble granules, soluble concentrate , soluble powder, tablet, direct use tablet, water dispersible tablet, water dispersible tablet, dispersible granules, wettable powder, block, concentrated gel in paste, emulsifiable gel, water soluble gel, emulsifiable granule, emulsifiable powder, oil dispersion or suspension, concentrated in oil, dispersible or easily mixed suspension, concentrated in oil, easily mixed solution in oil, powder, dispersible in oil, encapsulated granules, dry powder, electrostatic/electrodynamic spray liquid, granules, oil for spraying/distributing, ultra-low volume active suspension, ultra low volume active microgranules, fine powder, fine granules, contact powder, direct use tablet, liquid or contact gel, concentrated direct use suspension, other direct use liquids, other powders, direct use powder dry seed treatment, seed treatment emulsion, concentrated seed treatment suspension, seed treatment solution, soluble seed treatment powder, oil paste powder, water paste powder, encapsulated seed treatment suspension, seed treatment gel , aerosol, fumigant, fumigation insert, fumigation candle, fumigation cartridge, fumigation stick, fumigation tablet, fumigation granule, liquefied gas, gas generator, thermal spray concentrate, cold spray concentrate, varnish film, vegetable Rod, Paste, Bait, Powder Bait, Block Bait, Granular Bait, Plate Bait, Piece Bait, Steamer, Oil Paste, Prescription Bag, Auxiliary, Sprayer and Adhesion Sprayer.

Other exemplary additives that may be used in the compositions provided herein include, without limitation, at least one of compatibilizers, antifoaming agents, binding agents, neutralizing agents and buffers, corrosion inhibitors, coloring agents, fragrance agents, agents, distribution enhancers, penetration enhancers, fixing agents, dispersants, thickeners, freezing point depressants, antimicrobial agents, etc.

In another aspect, the compositions of the present invention further comprise at least one adjuvant or at least one antidote.

In one embodiment, the combinations of the present invention can be applied to a growing site either simultaneously or sequentially so that the three herbicides can be applied in a tank mix or premixed composition.

Thus, in this aspect, the present invention provides a tank-mix combination comprising:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the present invention may further provide at least one antidote and may be applied either pre- or post-emergence. The advantage of the combination is unexpectedly good residual effects when applied pre-emergence, as well as a rapid knockdown effect when applied after emergence, resulting in rapid weed control. In another embodiment, the present invention can be used to rapidly kill weeds. Another advantage is the quick knockdown effect in case of destruction.

In specific embodiments, the synergistic effect of combinations or compositions of compounds in accordance with the present invention occurs on the target weed either before or after emergence.

The control method of the present invention can be carried out by spraying the proposed tank mixtures or the individual herbicides can be formulated as a composite kit containing various components that can be mixed according to instructions before spraying.

The present invention also relates to a method of using the synergistic herbicidal compositions of the present invention to control weeds in plantations.

This method involves the following stages:

A) selection of agricultural plantation area;

B) applying a sufficiently effective amount of the herbicidal composition of the present invention or herbicidal product of the present invention to each plant or environment.

This composition can be applied to any vegetative part of plants present in a crop, either directly or by exposing the compounds to the environment. Application of the composition or finished product can be carried out in various ways, such as dipping, spraying, evaporation, aerosolization, application directly to seeds and also application directly to soil, parts of leaves and straw on the soil, among other possibilities.

Target weeds can be selected from Alopecurus myosuroides Huds. (Foxtail amaranth, ALOMY), Amaranthus palmeri (Palmer amaranth, AMAPA), Amaranthus viridis (Slim amaranth, AMAVI), Avena fatua (Oatmeal, AVEFA), Brachiaria decumbens Stapf. or Urochloa decumbens (Stapf), Brachiaria brizantha or Urochloa brizantha, Brachiaria platyphylla (Groseb.), Nash or Urochloa platyphylla (broadleaf branch, BRAPP), Brachiaria plantaginea. or Urochloa plantaginea (BRAPL), Cenchrus echinatus (CENEC), Digitaria horizontalis Willd. (Jamaican crabgrass, DIGHO), Digitaria insularis (sour grass, TRCIN), Digitaria sanguinalis (great crabgrass, DIGSA), Echinochloa crus-galli (common barnyard grass, ECHCG), Echinochloa colonum (barnyard grass, ECHCO), Eleusine indica Gaertn. (Eleusina indica, ELEIN), Lolium multiflorum Lam. (Italian ryegrass, LOLMU), Panicum dichotomiflorum Michx. (split-flowered millet, PANDI), Panicum miliaceum L. (common millet, PANMI), Sesbania exaltata (SEBEX), Setaria faberi Herrm. (Faber bristle, SETFA), Setaria viridis (green bristle, SETVI), Sorghum halepense (Aleppo sorghum, SORHA), Sorghum bicolor, Moench ssp., Arundinaceum (Sudan grass, SORVU), Cyperus esculentus (ground almond, CYPES), Cyperus rotundus (roundweed, CYPRO), Abutilon theophrasti (Theophrastus's rope, ABUTH), Amaranthus spp. (goosefoot and amaranth spp., AMASS), Ambrosia artemisiifolia L. (ambrosia wormwood, AMBEL), Ambrosia psilostachya DC. (ragweed, AMBPS), Ambrosia trifida, Anoda cristata, ANVCR, Asclepias syriaca, ASCSY, Bidens pilosa, BIDPI, Borreria species (BOISS), Borreria alata, or Spermacoce alata Aubl., or Spermacoce latifolia (BOILF), Chenopodium album L. (white pigweed, CHEAL), Cirsium arvense (field sow thistle, CIRAR), Commelina benghalensis (COMBE), Datura stramonium ( Datura, DATST), Daucus carota (wild carrot, DAUCA), Euphorbia heterophylla (spurge, EPHHL), Euphorbia hirta or Chamaesyce hirta (spurge, EPHHI), Euphorbia dentata Michx. (spurge, EPHDE), Erigeron bonariensis or Conyza bonariensis (Eribo), Erigeron canadensis or Conyza canadensis (ERICA), Conyza sumatrensis (ERIFL), Helianthus annuus (HELAN), Jacquemontia tamnifolia (IAQTA), Ipomoea hederacea (IPOHE), Ipomoea lacunosa (IPOLA), Lactuca serriola (LACSE), Portulaca oleracea (POROL), Richardia spp. (RCHSS) , Salsola tragus (SAS KR), Sida spp. (SIDSS), Sida spinosa (SIDSP), Sinapis arvensis (field mustard, SINAR), Solanum ptychanthum (Eastern black nightshade, SOLPT), Tridax procumbens ( tridax recumbent, TRQPR), Rumex dentatus (RUMDE) or Xanthium strumarium (common cocklebur, XANST).

In another embodiment, the weed is selected from a complex of plants from the genus Crabgrass (Digitaria horizontalis, Digitaria nuda and others), Guinea millet (Panicum maximum), creeping brachiaria (Brachiaria decumbens), bindweed species (Ipomoea grandifolia, Ipomoea nil, Ipomoea quamoclit, Ipomoea purpurea , Ipomoea hederifolia, Merremia cissoides and Merremia aegypta), hairy string (Bidens pilosa), Java grass (Cyperus rotundus and Cyperus spp.), Indian or buttercup grass (Eleusine indica), Cenchrus echinatus, velvet beans or mucuna (Mucuna pruriens), wild poinsettia or milkweed (Euphorbia heterophylla), Paraguayan burdock (Acanthospermum australe), amaranth (Amaranthus viridis), shrub (Brachiaria plantaginea), Commelina benghalensis, Emilia sonchifolia , wild poinsettia or milkweed (Euphorbia heterophylla), small-flowered galinsoga (Galinsoga parviflora), portulaga or goosefoot (Portulaca oleracea), Brazilian Richardia or Brazilian dandura (Richardia brasiliensis), round-leaved mallow (Sida cordifolia), southern sida (Sida glaziovii), sida rhombifolia (Sida rhombifolia), spermacoca or broadleaf spermacoca (Spermacoce latifólia).

In one preferred embodiment, the weed is selected from the group consisting of Amaranthus, Cyperus and Brachiaria decumbens, Cenchrus echinatus, Eleusine indica, Digitaria insularis, Ipomoea grandifolia, Euphorbia heterophylla, Commelina benghalensis, Amaranthus viridis, Amaranthus spinosus, Acalypha indica, Commelina communis, Digera arvensis, Euphorbia geniculate, Portulaca oleracea, Parthenium hysterophrous, Phyllanthus maderaspatnesis, Bracchiria spp, Dactyloctenium ageptisian and Echinochloa colonum.

In another embodiment, a method of using the herbicidal combination comprises the following steps:

a) choosing the area for growing an agricultural crop;

b) application of a sufficiently effective amount of said product to plants and/or directly to the environment/site/soil.

In another embodiment, the composition is used as a pre-emergence treatment or a post-emergence treatment. In a preferred embodiment, the composition is contacted with the crop at an application rate of 0.01 kg/ha to 10 kg/ha.

In another embodiment, the present invention provides the use of the herbicidal combinations or compositions of the present invention to obtain a herbicidal product for use in the control of weeds present in crops.

Typically, the use of the combinations/compositions of the present invention provides synergistic control of one or more weeds.

In one embodiment, the present invention provides a composite kit containing multiple components, wherein the multiple components include:

(a) at least one triazolone herbicide selected from amicarbazone, bencarbazone, carfentrazone, flucarbazone, ipfencarbazone, propoxycarbazone, sulfentrazone or thiencarbazone;

(b) at least a photosystem II inhibitor selected from the group consisting of (i) a phenylcarbamate herbicide; (ii) a triazine herbicide; (iii) a triazinone herbicide; (iv) a uracil-based herbicide; (v) a benthiadiazole herbicide; (vi) a nitrile-based herbicide and (vii) a urea-based herbicide; And

(c) at least a third herbicide selected from a 4-HPPD inhibitor, a bleaching inhibitor, a cell division inhibitor, a PPO inhibitor, an ALS inhibitor, a microtubule assembly inhibitor, or a cellulose biosynthesis inhibitor.

In one embodiment, the composite kit contains instructions for use, wherein said instructions for use contain instructions requiring the user to mix the components before use.

In one embodiment, the components of the present invention may be packaged such that the photosystem II inhibitor, ALS inhibitor, and chlorophyll heme biosynthesis inhibitor may be packaged separately and then mixed into a tank mix prior to spraying.

In another embodiment, the components of the present invention may be packaged such that the triazolone herbicide, the photosystem II inhibitor, and at least the third herbicide may be packaged separately, and the other additives may be packaged separately such that the two components may be mixed together. tank mixture while spraying.

In another embodiment, the components of the present invention may be packaged as a composition such that the triazolone herbicide, the photosystem II inhibitor, and at least a third herbicide are formulated in one composition and the other additives are packaged separately so that the two components can be mixed into the tank mixture while spraying.

The herbicidal compositions of the present invention may be presented in any conventional form suitable from an agricultural point of view. They may be solids, such as, for example, dusty powders, granules, water-dispersible granules, microcapsules or wettable powders, or liquids, such as, for example, emulsifiable concentrates, solutions, emulsions or suspensions, ZC formulations. They may also be provided, for example, in the form of a ready-to-use formulation or in the form of a tank mixture.

In one aspect, the individual components of the combination of the present invention can be applied to a growing site either simultaneously or sequentially, and the herbicide used together can be applied in a tank mix or as a premixed composition.

In one tank-mix embodiment, the herbicide combination formulation is mixed into the tank-mix prior to use in a suitable ratio to provide the target weight ratio of active ingredients.

In one embodiment, the herbicidal compositions of the present invention are tank mixtures.

Application rates of the composition or tank-mixed active ingredients formulated separately will vary according to prevailing conditions such as weeds of the target self-seeded crops, degree of weed infestation, weather conditions, soil conditions, crop species, method of application and timing of application.

In one embodiment, application rates of the composition of the present invention may range from 1 to 5000 g/ha, but preferably from 5 to 1000 g/ha.

The herbicidal product described above is herbicidal effective.

The present invention provides a method for controlling unwanted plants, the method comprising applying to the unwanted plants or their habitat a herbicidal effective amount of the compositions of the present invention.

The method of application of agrochemicals depends on the selectivity and mechanism of action of the active ingredient. Applications using PPI are usually carried out in the case of volatile active ingredients.

Surprisingly, the present inventors discovered that a triazolone herbicide, a photosystem II inhibitor, and at least a third herbicide of the present invention were ineffective for weed control when used individually, but exhibited excellent synergistic control when used together. The combination provided control of the weed both pre- and post-emergence. As will be demonstrated in the examples, a combination of herbicides synergistically controls broadleaf weeds as well as grasses and sedges in situ. Therefore, the present invention provides advantageous methods for controlling both pre- and post-emergence weeds. The method of the present invention also provides a wider range of weeds to be controlled, which aids in resistance management by preventing the weed from becoming resistant to any of the herbicides, while providing a wider range of control at lower application rates.

An exemplary combination in accordance with the present invention has been used to control sedge and broadleaf weeds in crops, turf, ornamentals and landscaping. The exemplary combination is intended for post-emergence sedge control and control/suppression of a variety of broadleaf and grassy weeds.

Example 1

Field trials were conducted to evaluate the effectiveness of combinations of three active ingredients according to the present invention for post-emergence use at various application rates compared to working standards - single molecules and two-component mixtures of molecules for effectiveness against ground almond. The active ingredient combination used in the trial was bentazone+halosulfuron+sulfentrazone. The trial was conducted in Blacksburg, Virginia, and initiated on June 6 according to this protocol. The plots were in fallow areas occupied mainly by ground almond and tall fescue and were sprayed at 4-week intervals (2 applications in total). The application dosages of herbicides when used individually and when used in combinations were as follows.

From these tests the following results were noted.

The percentage of weed cover in these treatment trials was observed and tabulated as shown below:

Thus, it was found that the combination of halosulfuron, bentazone and sulfentrazone at each rate provided superior control of ground almond compared to each product alone and two-component mixtures. A clear response to the rate of the three-component combination was observed at application rates ranging from low to high. The three-part combination provided faster kill and longer residual control. The use of this three-part combination with three different modes of action helped provide resistance management and superior weed control.

Example 2

Field trials were conducted to evaluate the effectiveness and synergism of triple mixtures of amicarbazone with other herbicides for weed control when applied pre- and post-emergence.

The composition of the present invention was used. This test was carried out on the example of weed species: grasses, namely BRADC = Brachiaria decumbens , CCHEC = Cenchrus echinatus , ELEIN = Eleusine indica , TRCIN = Digitaria insularis, and broadleaf weeds, namely IAQGR = Ipomoea grandifolia , EPHHL = Euphorbia heterophylla , COMBE = Commelina benghalensis . Data were collected at different periods after application of the composition to the soil and calculations were carried out. The results of the tests performed are presented in the tables below.

Table 1

• g a. i./ha - grams of active ingredient per hectare; DAA - days after application

table 2

Table 3

Table 4

Table 5

Table 6

Table 7

Table 8

Table 9

Table 10

Table 11

From the results presented above, it can be concluded that the synergy between the compounds presented in the composition that is the object of the present invention has been confirmed for several ratios.

Claims (32)

1. Synergistic herbicide mixture for weed control in agricultural crops, containing: (a) amicarbazone; (b) at least a photosystem II inhibitor selected from atrazine, diuron, ametrine, and (c) at least a third herbicide selected from isoxaflutole, clomazone, sulfentrazone, mesotrione, S-metolachlor, where the specified mixture is selected from: (i) mixtures of amicarbazone, isoxaflutole and atrazine; (iv) mixtures of amicarbazone, clomazone and diuron; (vii) mixtures of amicarbazone, S-metolachlor and atrazine; (viii) mixtures of amicarbazone, sulfentrazone and diuron; And (x) mixtures of amicarbazone, mesotrione and ametrine. 2. The mixture according to claim 1, wherein said amicarbazone is present in an amount ranging from 1.0 to 99.0% by weight of the entire composition. 3. The mixture according to claim 1, where the rate of use of amicarbazone is in the range from 50 to 1000 g a. i./ha. 4. Herbicidal composition containing the herbicidal mixture according to claim 1 and at least one auxiliary substance. 5. The composition of claim 4, wherein the composition provides synergistic control of one or more weeds. 6. The composition according to claim 4, where the weed is selected from the group consisting of Amaranthus, Cyperus and Brachiaria decumbens, Cenchrus echinatus, Eleusine indica, Digitaria insularis, Ipomoea grandifolia, Euphorbia heterophylla, Commelina benghalensis, Amaranthus viridis, Amaranthus spinosus, Acalypha indica, Commelina communis, Digera arvensis, Euphorbia geniculate, Portulaca oleracea, Parthenium hysterophrous, Phyllanthus maderaspatnesis, Bracchiria spp, Dactyloctenium ageptisian and Echinochloa colonum. 7. A method of controlling unwanted weeds, comprising bringing the mixture into contact with a crop or non-agricultural area in need of weed control or at risk of unwanted weeds, in an amount effective to provide weed control in the crop, wherein the mixture contains: (a) amicarbazone; (b) at least a photosystem II inhibitor selected from atrazine, diuron, ametrine, and (c) at least a third herbicide selected from isoxaflutole, clomazone, sulfentrazone, mesotrione, S-metolachlor, where the specified mixture is selected from: (i) mixtures of amicarbazone, isoxaflutole and atrazine; (iv) mixtures of amicarbazone, clomazone and diuron; (vii) mixtures of amicarbazone, S-metolachlor and atrazine; (viii) mixtures of amicarbazone, sulfentrazone and diuron; And (x) mixtures of amicarbazone, mesotrione and ametrine. 8. The method of claim 7, wherein the agricultural crop is selected from the group consisting of cereals, rice, maize, sorghum, sugarcane, cotton, canola, turf, barley, potatoes, sweet potatoes, sunflowers, rye, varieties of oats, wheat, corn, soybeans, sugar beets, tobacco, safflower, tomato, alfalfa, pineapple and cassava. 9. A method of combating unwanted vegetation, including the following stages: a) choosing the area for growing an agricultural crop; b) applying an effective amount of the herbicidal mixture according to claim 1 or the herbicidal composition according to claim 4 to plants and/or directly to the environment or growing area or soil. 10. The method of claim 9, wherein the mixture or composition is used as a pre-emergence treatment or a post-emergence treatment. 11. The method according to claim 9, where the mixture or composition is brought into contact with the crop at an application rate of 0.01 to 10 kg/ha. 12. Use of the herbicide mixture according to any one of paragraphs. 1-3 as active ingredients for obtaining a herbicidal product for controlling weeds in agricultural crops.