RU2800618C2 - Nicotine gel - Google Patents

Abstract

FIELD: aerosol generating systems.

SUBSTANCE: group of inventions relates to a gel based on an alkaloid compound or based on a cannabinoid compound, which is used with an aerosol generating device, and its use. A gel-like composition for generating an aerosol, containing: an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, wherein the alkaloid compound is selected from the group consisting of nicotine, anatabine, and combinations thereof, while the cannabinoid compound is selected from the group consisting of from cannabidiol (CBD), tetrahydrocannabinol (THC), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabielsoin (CBE), cannabicitran (CBT), and combinations thereof; from 50 wt.% to 80 wt.% glycerol; from 0.2 wt.% to 5 wt.% gelling agent providing crosslinking through ionic bonds, and the gelling agent providing crosslinking through ionic bonds includes low acyl gellan, pectin, kappa-carrageenan, iota-carrageenan or alginate; from 0.2 wt.% to 5 wt.% of a viscosity increasing agent and/or from 0.2 wt.% to 5 wt.% of a gelling agent providing crosslinking through hydrogen bonds, while the viscosity increasing agent includes one or more xanthan gum, carboxymethylcellulose, microcrystalline cellulose, methylcellulose, gum arabic, guar gum, lambda carrageenan, or starch, wherein the hydrogen bonding gelling agent comprises one or more of galactomannan, gelatine, agarose, konjac gum, or agar, and lactic acid or levulinic acid. Use of the above-described gel composition with an aerosol generating device to heat the gel composition to vaporize an alkaloid compound or a cannabinoid compound or both an alkaloid compound and a cannabinoid compound.

EFFECT: above-described gel composition is stable, essentially retains its shape and weight.

12 cl, 3 dwg, 2 tbl, 9 ex

Description

The present invention relates to a gel based on an alkaloid compound or based on a cannabinoid compound that can be used with an aerosol generating device. In some aspects, the present invention relates to a nicotine gel that can be used with an aerosol generating device.

Nicotine compositions are known for use with aerosol generating products. Often, the nicotine composition is a liquid composition, such as an electronic cigarette liquid, that is heated by a helical electrically resistive filament of an aerosol generating article. In order to avoid accidental leakage of a liquid composition, great care is taken in the manufacture of containers containing this liquid composition. Accidental leakage may particularly occur when the container is made of paper, cardboard, or any material that can absorb or be damaged by the liquid nicotine composition.

The use of alternative formulations containing nicotine may reduce potential leakage problems. However, these alternative forms of compositions containing nicotine may change the phase from gel to liquid over time. In particular, gel forms of compositions containing nicotine may release a liquid phase during storage or during the period from manufacture to consumption by the user. This is especially true for gel compositions containing a high level of glycerol, a low level of water, or both a high level of glycerol and a low level of water.

It would be desirable to provide a gel-like composition containing an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol with increased physical stability. It would be desirable to provide a gel-like composition containing an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol which can be physically stable. It would be desirable to provide a gel-like composition containing an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol that does not release a liquid phase under a wide range of storage conditions. It would be desirable to provide a gel-like composition containing an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol that does not absorb the liquid phase. It would be desirable to provide a gel-like composition in which an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol evaporates within the composition upon heating. It would be desirable to provide a gel-like composition containing an alkaloid compound such as nicotine or a cannabinoid compound such as cannabidiol or tetrahydrocannabinol that does not leak from an aerosol generating device.

Various aspects of the present invention relate to gel compositions that contain an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound. Various aspects of the present invention relate to gel compositions that contain nicotine. These gel compositions cannot release or absorb water over a wide range of relative humidity (such as about 10% to about 60% relative humidity, for example). The gel composition contains: an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound; glycerol; a gelling agent that provides crosslinking through hydrogen bonds; an ionically crosslinking gelling agent, a viscosity increasing agent, and an acid.

The gel composition may contain: an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound; at least about 50 wt.% glycerol or at least 70 wt.% glycerol; at least about 0.2 wt.% gelling agent, providing crosslinking through hydrogen bonds; at least about 0.2% by weight of an ionically crosslinking gelling agent, at least about 0.2% by weight of a viscosity increasing agent, and an acid.

The gel composition may contain: nicotine; at least about 50 wt.% glycerol or at least 70 wt.% glycerol; at least about 0.2 wt.% gelling agent, providing crosslinking through hydrogen bonds; at least about 0.2 wt.% gelling agent, providing crosslinking through ionic bonds; at least about 0.2 wt.% means to increase the viscosity and acid.

The gel composition may contain a viscosity increasing agent, a hydrogen bonding gelling agent, and an ionic crosslinking gelling agent in a total amount of from about 1% to about 8% by weight.

The gel composition may contain from about 0.5% to about 2% by weight of a viscosity increasing agent. The gelled composition may contain from about 0.5% to about 2% by weight of a hydrogen bonding gelling agent. The gel composition may contain from about 0.5 wt.% to about 2 wt.% gelling agent, providing crosslinking through ionic bonds. The gel composition may contain from about 0.5 wt.% to about 2 wt.% of a viscosity increasing agent, from about 0.5 wt.% to about 2 wt.% of a gelling agent that provides crosslinking through hydrogen bonds, and from about 0 .5 wt.% to about 2 wt.% gelling agent, providing crosslinking through ionic bonds. The viscosity increasing agent, the hydrogen bonding gelling agent, and the ionic crosslinking gelling agent may each be present in the gel composition in substantially equal amounts by weight.

The gel composition may contain: from about 0.5% to 2.5% by weight of an alkaloid compound, or from about 0.5% to 2.5% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in total from about 0.5% to 2.5 wt.%; from about 70% to 80 wt.% glycerol; from about 0.5% to 2 wt.% gelling agent, providing crosslinking through hydrogen bonds; from about 0.5% to 2 wt.% gelling agent, providing crosslinking through ionic bonds; from about 0.5% to 2 wt.% means to increase the viscosity; from about 15% to about 25 wt.% water; divalent cations and acid. The viscosity increasing agent, the hydrogen bonding gelling agent, and the ionic crosslinking gelling agent may each be present in the gel composition in substantially equal amounts by weight.

The gel composition may contain: from about 0.5% to 2.5 wt.% nicotine; from about 70% to 80 wt.% glycerol; from about 0.5% to 2 wt.% gelling agent, providing crosslinking through hydrogen bonds; from about 0.5% to 2 wt.% gelling agent, providing crosslinking through ionic bonds; from about 0.5% to 2 wt.% means to increase the viscosity; from about 15% to about 25 wt.% water; divalent cations and acid. The viscosity increasing agent, the hydrogen bonding gelling agent, and the ionic crosslinking gelling agent may each be present in the gel composition in substantially equal amounts by weight.

The gel composition may contain: from about 1.5% to 2.5% by weight of an alkaloid compound, or from about 1.5% to 2.5% by weight of a cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in a total amount of about 1.5% to 2.5 wt.%; from about 70% to about 75 wt.% glycerol; from about 18% to about 22 wt.% water; from about 0.5% to about 2 wt.% each of agar, xanthan gum and low acyl gellan; calcium ions; and a carboxylic acid, such as lactic acid. Each of xanthan gum, agar and low acyl gellan may be present in the gel composition in substantially equal amounts by weight.

The gel composition may contain: from about 1.5% to about 2.5 wt.% nicotine; from about 70% to about 75 wt.% glycerol; from about 18% to about 22 wt.% water; from about 0.5% to about 2 wt.% each of agar, xanthan gum and low acyl gellan; calcium ions; and a carboxylic acid, such as lactic acid. Each of xanthan gum, agar and low acyl gellan may be present in the gel composition in substantially equal amounts by weight.

The gelled composition may contain a gelling agent that forms a solid medium, glycerol dispersed in a solid medium, and an alkaloid compound or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, dispersed in glycerin. The composition forms a stable gel phase.

The gel composition may contain a gelling agent that forms a solid medium, glycerin dispersed in a solid medium, and nicotine dispersed in glycerin. The composition forms a stable gel phase.

The gelled composition may contain at least two solid medium gelling agents, glycerol dispersed in the solid medium and an alkaloid compound or a cannabinoid compound or both an alkaloid compound and a cannabinoid compound dispersed in the glycerin. The composition forms a stable gel phase.

The gelled composition may contain at least two solid medium gelling agents, glycerol dispersed in the solid medium and nicotine dispersed in the glycerin. The composition forms a stable gel phase.

The gelled composition may contain a viscosity increasing agent and a solid medium gelling agent, glycerin dispersed in the solid medium and an alkaloid compound or a cannabinoid compound or both an alkaloid compound and a cannabinoid compound dispersed in the glycerin. The composition forms a stable gel phase.

The gel composition may contain a viscosity increasing agent and a solid medium gelling agent, glycerin dispersed in the solid medium, and nicotine dispersed in the glycerin. The composition forms a stable gel phase.

The gelled composition may contain a viscosity increasing agent and at least two solid medium gelling agents, glycerol dispersed in the solid medium and an alkaloid compound or a cannabinoid compound or both an alkaloid compound and a cannabinoid compound dispersed in the glycerin. The composition forms a stable gel phase.

The gel composition may contain a viscosity increasing agent and at least two solid medium gelling agents, glycerol dispersed in a solid medium and nicotine dispersed in glycerin. The composition forms a stable gel phase.

Additional aspects of the present invention may relate to the use of the composition by heating the composition to vaporize the alkaloid compound or the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound, and the use of the composition in which heating does not release the liquid phase from the composition.

Additional aspects of the present invention may relate to the use of the composition by heating the composition to vaporize nicotine and the use of the composition in which heating does not release the liquid phase from the composition.

Preferably at room temperature, the gel is a solid. "Solid" in this context means that the gel is of stable size and shape and does not flow. Room temperature in this context means 25 degrees Celsius. A gel can be defined as a substantially dilute crosslinked system that does not flow when at steady state. By mass, gels can be mostly liquids, however, they also behave like solids due to the three-dimensional cross-linked network environment in the liquid. It is the crosslinking within the fluid that provides the gel structure (hardness). Thus, gels can be a dispersion of liquid molecules in a solid medium in which liquid particles are dispersed in a solid medium.

Preferably the gel composition has a viscosity of about 1,000,000 to about 1 Pa per second, preferably 100,000 to 10 Pa per second, preferably 10,000 to 1000 Pa per second, or 1,000 to 100 Pa per second, or 500 to 200 Pa per second with obtaining the required viscosity. The viscosity of the gel composition can be measured by obtaining the viscosity of the sample using an Anton Paar MCR 302 rheometer using a PP25 parallel plate using a P-PTD200+H-PTD200 measuring cell at 25° C. with a shear rate of 1 s ^-1 .

The weight of the gelled composition may not change by more than about 20%, or may not change by more than about 15%, or may not change by more than about 10% when exposed to various storage conditions at ambient conditions. The composition may have an external shape with an exposed surface area that does not change by more than about 10%, or does not change by more than about 5%, or does not change by more than about 1% when exposed to various environmental conditions.

In one or more aspects, the gel composition has a mass that does not change by more than about 20%, or does not change by more than about 15%, or does not change by more than about 10% when exposed to a relative humidity in the range of about 10% to about 60% at 24 degrees Celsius and one atmosphere, or typical storage conditions.

In one or more aspects, the gel composition has an external form with an exposed surface area that does not change by more than about 10%, or does not change by more than about 5%, or does not change by more than about 1% when exposed to relative humidity in range from about 10% to about 60% at 24 degrees Celsius and one atmosphere.

In one or more aspects, the gel composition has an exposed surface area value (in m ² ) and a mass value (in kg), wherein the ratio of mass value to exposed surface area value is in the range of about 0.05:1 to about 1 :1, or about 0.1:1 to about 1:1, or about 0.5:1 to about 1:0.1, or about 0.5:1 to about 1:0.5.

Advantageously, the gel composition provides a predictable form of the composition during storage or transport from the manufacturer to the consumer. A gel composition containing an alkaloid compound or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, substantially retains its shape. A gel composition containing an alkaloid compound or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, does not substantially release a liquid phase during storage or transport from the manufacturer to the consumer. The gel-like composition containing nicotine essentially retains its shape. The gel-like composition containing nicotine essentially does not release the liquid phase during storage or transportation from the manufacturer to the consumer. The gelled composition can provide a simple consumable design. This consumable can be designed to contain no liquid, so a wider range of container materials and designs can be provided.

The gel composition described herein can be combined with an aerosol generating device to deliver the alkaloid compound aerosol to the lungs at inhalation or airflow rates that are within the range of inhalation or airflow rates in a normal smoking regimen. The aerosol generating device can continuously heat the gelled composition. The user may take multiple breaths or "puffs", where each "puff" delivers a certain amount of alkaloid compound aerosol. The gelled composition may be capable of delivering a high alkaloid/low total solids (TPM) aerosol to a consumer when heated, preferably in a continuous manner.

The gel composition described herein may be combined with an aerosol generating device to deliver nicotine aerosol to the lungs at inhalation or airflow rates that are within the range of inhalation or airflow rates in a normal smoking regimen. The aerosol generating device can continuously heat the gelled composition. The user may take multiple breaths or "puffs", where each "puff" delivers a certain amount of nicotine aerosol. The gel composition may be capable of delivering a high nicotine/low total solids (TPM) aerosol to a consumer when heated, preferably in a continuous manner.

The gel composition described herein can be combined with an aerosol generating device to deliver the cannabinoid compound aerosol to the lungs at inhalation or airflow rates that are within the range of inhalation or airflow rates in a normal smoking regimen. The aerosol generating device can continuously heat the gelled composition. The user may take multiple breaths or "puffs", where each "puff" delivers a specific amount of aerosol with the cannabinoid compound. The gel composition may be capable of delivering a high cannabinoid compound/low total solids (TPM) aerosol to a consumer when heated, preferably in a continuous manner.

The gel composition contains an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound. The gel composition may contain one or more alkaloids. The gel composition may contain one or more cannabinoids. The gel composition may contain a combination of one or more alkaloids and one or more cannabinoids.

The term "alkaloid compound" refers to any of a class of naturally occurring organic compounds that contain one or more basic nitrogen atoms. Typically, the alkaloid contains at least one nitrogen atom in an amine-type structure. This or another nitrogen atom in an alkaloid compound molecule can be active as a base in acid-base reactions. Most alkaloid compounds have one or more nitrogen atoms as part of a cyclic system such as, for example, a heterocyclic ring. In nature, alkaloid compounds are found mainly in plants and, in particular, they are especially common in certain families of flowering plants. However, some alkaloid compounds are found in animal species and fungi. In the present invention, the term "alkaloid compound" refers to both naturally derived alkaloid compounds and synthetically manufactured alkaloid compounds.

The gel composition may preferably contain an alkaloid compound selected from the group consisting of nicotine, anatabine, and combinations thereof.

Preferably the gel composition contains nicotine.

The term "nicotine" refers to nicotine and nicotine derivatives such as pure nicotine, nicotine salts, and the like.

The term "cannabinoid compound" refers to any of a class of naturally occurring compounds found in parts of the hemp plant, namely Cannabis sativa , Cannabis indica , and Cannabis ruderalis species. Cannabinoid compounds are especially concentrated in the heads of female flowers. Cannabinoid compounds found naturally in the hemp plant contain cannabidiol (CBD) and tetrahydrocannabinol (THC). In the present invention, the term "cannabinoid compounds" is used to describe both naturally derived cannabinoid compounds and synthetically manufactured cannabinoid compounds.

The gel may contain a cannabinoid compound selected from the group consisting of cannabidiol (CBD), tetrahydrocannabinol (THC), tetrahydrocannabinic acid (THCA), cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV), cannabigerol monomethyl ether (CBGM), cannabielsoin (CBE), cannabicitran (CBT), and combinations thereof.

The gel composition may preferably contain a cannabinoid compound selected from the group consisting of cannabidiol (CBD), THC (tetrahydrocannabinol), and combinations thereof.

The gel may preferably contain cannabidiol (CBD).

The gel composition may contain nicotine and cannabidiol (CBD).

The gel composition may contain nicotine, cannabidiol (CBD) and THC (tetrahydrocannabinol).

The phrase "stable gel phase" or "stable gel" refers to a gel that substantially retains its shape and mass under various environmental conditions. A stable gel may not actually release (moisturize) or absorb water when subjected to standard temperature and pressure as the relative humidity changes from about 10% to about 60%. For example, a stable gel can substantially retain its shape and mass when subjected to standard temperature and pressure as the relative humidity changes from about 10% to about 60%.

The term “viscosifying agent” refers to a compound that, when uniformly added to a mixture of 50 wt.% water/50 wt.% glycerol at a temperature of 25°C, in an amount of 0.3 wt.%, increases the viscosity without leading to the formation gel, while the mixture remains or remains liquid. Preferably, the viscosity increasing agent refers to a compound which, when uniformly added to a mixture of 50 wt.% water/50 wt.% glycerol at a temperature of 25°C, in an amount of 0.3 wt.% increases the viscosity to at least 50 cps, preferably at least 200 centipoise, preferably at least 500 centipoise, preferably at least 1000 centipoise at a shear rate of 0.1 s ^-1 without causing gel formation, while the mixture remains or remains liquid. Preferably, the viscosity increasing agent refers to a compound which, when uniformly added to a mixture of 50 wt.% water/50 wt.% glycerol at a temperature of 25°C in an amount of 0.3 wt.%, increases the viscosity by at least 2 times, or by at least 5 times, or at least 10 times, or at least 100 times, than before addition, at a shear rate of 0.1 s ^-1 without leading to the formation of a gel, while the mixture remains or remains liquid.

The viscosity values given in this document can be measured using a Brookfield RVT viscometer rotating an RV#2 disc type shaft at 25°C at 6 revolutions per minute (rpm).

The term "gelling agent" refers to a compound that, when uniformly added to a mixture of 50 wt.% water/50 wt.% glycerol in an amount of from about 0.3 wt.%, forms a solid medium or support matrix, leading to the formation of a gel. Gelling agents include, but are not limited to, hydrogen bonding gelling agents and ionic bonding gelling agents.

The term "gel" refers to a solid at room temperature. "Solid" in this context means that the gel is of stable size and shape and does not flow. Room temperature in this context means 25 degrees Celsius. A gel can be defined as a substantially dilute crosslinked system that does not flow when at steady state. By mass, gels can be mostly liquids, however, they also behave like solids due to the three-dimensional cross-linked network environment in the liquid. It is the crosslinking within the fluid that provides the gel structure (hardness). Thus, gels can be a dispersion of liquid molecules in a solid medium in which liquid particles are dispersed in a solid medium.

The term "hydrogen bonding gelling agent" refers to a gelling agent that forms non-covalent crosslinking bonds or physical crosslinking bonds through hydrogen bonding. Hydrogen bonding is a type of dipole-dipole electrostatic attraction between molecules rather than a covalent bond with a hydrogen atom. The result is an attractive force between a hydrogen atom covalently bonded to a highly electronegative atom, such as an N, O, or F atom, and another highly electronegative atom.

The term "gelling agent providing crosslinking through ionic bonds" refers to a gelling agent that forms non-covalent crosslinking bonds or physical crosslinking bonds through the formation of ionic bonds. Ionic crosslinking involves linking polymer chains through non-covalent interactions. A crosslinked network is formed when multivalent molecules of opposite charges are electrostatically attracted to each other, resulting in the formation of a crosslinked polymer network.

The gel composition described herein may be combined with an aerosol generating device to deliver an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, to a consumer. The gel composition described herein can be combined with an aerosol generating device to deliver nicotine to a consumer. The gel composition may be packaged separately (as a gel consumable) from a portion of the aerosol generating device, or not form a portion thereof. The spent gel consumable can be replaced with a fully charged gel consumable in the aerosol generating device. A plurality of these gel consumables can be combined with an aerosol generating device to form a kit.

The gelled composition described herein may be packaged in a sealed or closed container for transport from manufacture to consumer consumption. The gelled composition has an exposed surface area that is in contact with the upper space defined by the inner surface of the container. The headspace may have a relative humidity that is balanced by the gelled composition. The relative humidity of the upper space may actually be similar to the (local) humidity provided by the gelled composition.

The gel-like composition described herein may be packaged or contained within an aerosol generating article. The term "aerosol generating article" is used to describe an article capable of generating or releasing an aerosol. The aerosol generating article may form a tubular element which may be formed from fluid-permeable materials such as paper, cardboard, cotton, cellulose acetate, rayon, polylactic acid, or combinations thereof. The tubular element may include a wrapper. The wrapper may be made from fluid-permeable materials such as paper, cardboard, cotton, or combinations thereof.

"Tubular member" describes a component suitable for use in an aerosol generating article. Ideally, the tubular element may be longer in the longitudinal direction than in the width, but not necessarily, as it may be one part of a multi-component product, which ideally will be longer than its longitudinal length than its width. As a rule, the tubular element is cylindrical, but not necessarily. For example, the tubular element may have an oval, polygonal, eg triangular or rectangular, or arbitrary cross section.

An aerosol generating article may have an open end, a proximal end, and a distal end, which may be open or closed in various specific embodiments. The tubular element contains a gel-like composition and is preferably located near the distal end of the aerosol generating article. When negative pressure is applied to the open proximal end, the alkaloid compound and the cannabinoid compound are released from the gel composition. The aerosol generating article defines at least one opening between the proximal end and the distal end. The at least one opening defines at least one fluid inlet such that when negative pressure is applied to the open proximal end of the aerosol generating article, fluid, such as air, enters the aerosol generating article through the opening. Preferably, fluid, such as ambient air drawn into the aerosol generating article through the opening, flows along the outer longitudinal channel of the fluid guide towards the gelled composition near the distal end of the aerosol generating article. The fluid then flows through the inner longitudinal channel of the fluid guide from the distal end to the proximal end and out of the aerosol generating article at the open proximal end.

By positioning the opening at a distance from the distal end of the aerosol-generating article, the opening is separated from the tubular member containing the gelled composition, reducing the possibility of leakage of the gelled composition through the opening. In addition, by providing a channel, such as an outer longitudinal channel, for air to flow from the opening into the tubular member containing the gelled composition, the fluid from the opening can be directed towards the gelled composition and the fluid guide can act as an additional barrier between the gelled composition and hole. This has the advantage of further reducing the likelihood of leakage of the gelled composition through the opening. In addition, the inner longitudinal passage of the fluid guide provides a path for fluid, such as air, and material or vapor generated or released from the tubular to be drawn out of the aerosol generating article through the open proximal end.

Preferably, the aerosol generating article is generally cylindrical. This easily ensures a smooth flow of the aerosol. The aerosol generating article may have an outer diameter of, for example, 4 millimeters to 15 millimeters, 5 millimeters to 10 millimeters, or 6 millimeters to 8 millimeters. The aerosol generating article may have a length of, for example, 10 millimeters and 60 millimeters, 15 millimeters to 50 millimeters, or 20 millimeters to 45 millimeters.

The resistance to draw (RTD) of an aerosol generating article will vary depending on, among other things, the length and dimensions of the channels, the size of the openings, the dimensions of the most constricted cross section of the inner channel, and the materials used. In specific embodiments, the RTD of the aerosol-generating article is in the range of 50 millimeters of water (mm w.c.) to 140 millimeters of water (mm w.g.), 60 millimeters of water (mm w.g.) up to 120 millimeters of water column (mm of water column) or from 80 millimeters of water column (mm of water column) to 100 millimeters of water column (mm of water column). The RTD of an article refers to the static pressure difference between one or more orifices and the mouth end of the article during passage through an internal longitudinal bore under steady state conditions in which the volume flow is 17.5 milliliters per second at the mouth end. The RTD of a sample can be measured using the method described in ISO 6565:2002.

In particular embodiments, the aerosol generating article comprises a plastic material; metallic material; cellulosic material such as cellulose acetate; paper; cardboard; cotton; or their combinations.

In particular embodiments, the fluid guide comprises a plastic material, a metal material, a cellulosic material such as cellulose acetate, paper, cardboard, or combinations thereof.

In combination with specific embodiments, the wrapper contains more than one material. In specific embodiments, the implementation of the wrapper or part of it contains a metal material, plastic material, cardboard, paper, cotton, or combinations thereof. When the wrapper contains cardboard or paper, the holes may be formed by laser cuts.

The wrapper provides strength and structural rigidity to the aerosol generating article. When using paper or paperboard for wrapping and a high degree of rigidity, it is desirable that their density is preferably more than 60 grams per square meter. One such wrapper can provide high structural rigidity. The wrapper may be resistant to deformation on the outside of the aerosol-generating article, at the location where, if present, the stopper is inserted into the aerosol-generating article, or at other locations, such as in cavities (if present), where there is less structural support. In some embodiments, the implementation of the tubular element wrap contains a metal layer. The metal layer can be used to concentrate external energy supplied to heat the tubular, for example, the metal layer can act as a current collector for an electromagnetic field or collect radiation energy supplied by an external heat source. With an internal heat source, the metal layer can prevent heat from escaping from the tubular through the wrapper, thereby increasing the heating efficiency. It may also provide uniform distribution of heat along the periphery of the tubular element.

In particular embodiments, the aerosol generating article comprises a seal between the outside of the fluid guide and the inside of the wrapper. The wrapper can then be securely attached to the fluid guide. This does not require a fluid-tight seal.

In particular embodiments, the aerosol generating article comprises a mouthpiece. The mouthpiece may comprise a fluid guide, or a portion thereof, and may form at least the proximal portion of the wrapper of the aerosol generating article. The mouthpiece may be connected to the wrap or back wrap in any suitable manner, such as by an interference fit, threaded connection, or the like. The mouthpiece may be part of an aerosol generating article which may contain a filter, or in some cases the mouthpiece may be formed by a length of rim paper, if present. In other embodiments, the mouthpiece may be formed as part of the article extending 40 millimeters from the mouth end of the aerosol generating article or extending 30 millimeters from the mouth end of the aerosol generating article.

The tubular member containing the gelled composition may be positioned in the aerosol generating article near the distal end prior to final assembly of the aerosol generating article.

Once fully assembled, the aerosol generating article defines a fluid path through which the fluid can flow. When negative pressure is provided at the mouth end (proximal end) of the aerosol-generating article, fluid enters the aerosol-generating article through an opening in the wrap (or fluid guide, or both), then flows through the outer longitudinal passage toward the distal end of the aerosol generating article. In this case, the aerosol may be captured, optionally, by heating the tubular member holding the gelled composition. The fluid with the entrained aerosol can then flow through the inner longitudinal channel of the fluid guide and through the open mouth end of the aerosol generating article.

Preferably, the aerosol generating article is configured to be placed in the aerosol generating device such that the heating element of the aerosol generating device can heat a section of the aerosol generating article that includes the tubular member. For example, the tubular member may be the distal end of the aerosol generating article, wherein the tubular member containing the gelled composition should be located at or near the distal end of the aerosol generating article.

Preferably, the aerosol generating article may be shaped and sized for use with an aerosol generating device having a suitable and appropriate shape and size, comprising a reservoir to receive the aerosol generating article, and a heating element configured and positioned to heat a section of the aerosol generating article. an aerosol that contains a tubular element containing a gel-like composition.

The aerosol generating device preferably comprises control electronics operatively connected to the heating element. The control electronics may be configured to control the heating of the heating element. The control electronics may be located inside the housing of the device.

The gel composition according to the present invention contains: an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound; an aerosol generating agent; viscosity increasing agent; a gelling agent that provides crosslinking through hydrogen bonds; a gelling agent providing crosslinking through ionic bonds; and an acid. The gel composition may further contain divalent cations.

The gel composition according to the present invention contains: nicotine; an aerosol generating agent; viscosity increasing agent; a hydrogen bonding gelling agent; and an ionic bonding gelling agent; and an acid. The gel composition may further contain divalent cations.

The gel-like composition contains an aerosol generating agent. Ideally, the aerosol generating agent is substantially resistant to thermal degradation at the operating temperature of the associated aerosol generating device. Suitable aerosol forming agents include, but are not limited to: polyhydric alcohols such as triethylene glycol, 1,3-butanediol, and glycerin; esters of polyhydric alcohols such as glycerol mono-, di- or triacetate; and aliphatic esters of mono-, di- or polycarboxylic acids such as dimethyl dodecanedioate and dimethyl tetradecanedioate. The polyhydric alcohols or mixtures thereof may be one or more of the following: triethylene glycol, 1,3-butanediol and glycerol (glycerol or propane-1,2,3-triol) or polyethylene glycol. The aerosol forming agent is preferably glycerol.

The gelled composition may contain most of the material to form an aerosol. The gelled composition may contain a mixture of water and an aerosolizing agent, with the aerosolizing agent forming the majority (by weight) of the gelled composition. The aerosolizing agent may form at least about 50% by weight of the gelled composition. The aerosolizing agent may form at least about 60 wt.%, or at least about 65 wt.%, or at least about 70 wt.% of the gel-like composition. The aerosolizing agent may form from about 70% to about 80% by weight of the gelled composition. The aerosolizing agent may form from about 70% to about 75% by weight of the gelled composition.

The gel composition may contain most of the glycerin. The gel composition may contain a mixture of water and glycerin, where glycerin forms the majority (by weight) of the gel composition. Glycerin may form at least about 50% by weight of the gelled composition. Glycerin can form at least about 60 wt.%, or at least about 65 wt.%, or at least about 70 wt.% of the gel composition. Glycerin can form from about 70 wt.% to about 80 wt.% gel-like composition. Glycerin may form from about 70% to about 75% by weight of the gelled composition.

The gel composition preferably contains no water or contains a low level of water. If the gel composition does not contain water or contains a low level of water, the gel composition may contain high levels of other compounds such as aerosolizer, gelling agent, viscosity increasing agent and nicotine. In addition, a gel-like composition containing no water or containing a low water level is lighter and requires less energy to evaporate. Aerosols formed from a gel-like composition containing no water or containing a low level of water may be perceived as less hot by the user. Preferably the gel composition contains less than about 40 wt.%, preferably less than about 30 wt.%, preferably less than about 25 wt.% water. The gel composition may contain less than about 20 wt.%, or less than about 15 wt.%, or less than about 10 wt.%, or less than about 5 wt.% water.

The gel composition preferably contains some water. The gel composition is more stable if the composition contains some water. Preferably, the gel composition contains at least about 1 wt.%, or at least about 2 wt.%, or at least about 5 wt.% water. Preferably the gel composition contains at least about 10 wt.% or at least about 15 wt.% water.

Preferably the gel composition contains from about 8 wt.% to about 32 wt.% water. Preferably the gel composition contains from about 14 wt.% to about 26 wt.% water. Preferably the gel composition contains from about 18 wt.% to about 22 wt.% water. Preferably the gel composition contains about 20 wt.% water. Preferably the gel composition contains from about 15 wt.% to about 25 wt.% water.

The gel composition may contain a particular ratio of water content to glycerin to maintain a balanced local humidity with that of the environment. This range of water content in glycerin can provide the properties needed to maintain a gel-like composition. The gel composition will not substantially flow and will substantially retain its shape over time. The gel composition will not substantially flow and will substantially retain its weight over time. The gel will not substantially release water (smoke) or absorb water over time when exposed to environmental or storage conditions.

Preferably, the gel composition contains an aerosolizing agent or a ratio of glycerol to water in the range of about 10:1 to about 2:1, or in the range of about 5:1 to about 3:1. Preferably, the gel composition contains an aerosolizing agent or a ratio of glycerol to water in the range of about 4.5:1 to about 3.5:1.

The gel composition may contain gelling agents, which are a gelling agent that provides crosslinking through hydrogen bonds, and a gelling agent that provides crosslinking through ionic bonds. The gel composition may further comprise a viscosity increasing agent. Gelling agents can form a solid medium in which the aerosolizing agent can be dispersed. Gelling agents can form a solid medium in which the aerosolizing agent and water can be dispersed. A viscosity increasing agent in combination with a hydrogen bonding gelling agent and an ionic crosslinking gelling agent appears to surprisingly maintain a solid medium and maintain a gelled composition even if the gelled composition contains a high level of glycerol.

The gelled composition may contain gelling agents in the range of from about 0.4% to about 10% by weight. Preferably, the composition contains gelling agents in the range of from about 0.5% to about 8% by weight. Preferably, the composition contains gelling agents in the range of about 1% to about 6% by weight. Preferably, the composition contains gelling agents in the range of about 2% to about 4% by weight. Preferably, the composition contains gelling agents in the range of about 2% to about 3% by weight.

The gel composition contains a viscosity increasing agent in the range of about 0.2% to about 5% by weight. Preferably, the composition contains a viscosity increasing agent in the range of about 0.5% to about 3% by weight. Preferably, the composition contains a viscosity increasing agent in the range of about 0.5% to about 2% by weight. Preferably, the composition contains a viscosity increasing agent in the range of about 1% to about 2% by weight.

The gel composition may contain a viscosity increasing agent, a hydrogen bonding gelling agent, and an ionic bonding gelling agent present in the gelled composition in a total amount of from about 1% to about 8% by weight. Preferably, the gel composition may contain a viscosity increasing agent, a hydrogen bonding gelling agent, and an ionic bonding gelling agent present in the gel composition in a total amount of from about 2 wt.% to about 6 wt.%. Preferably, the gel composition may contain a viscosity increasing agent, a hydrogen bonding gelling agent, and an ionic bonding gelling agent present in the gel composition in a total amount of from about 3 wt.% to about 5 wt.%.

The gel composition may contain a viscosity increasing agent, a hydrogen bonding gelling agent, and an ionic bonding gelling agent, each independently present in the gel composition in the range of from about 0.3 wt.% to about 3 wt. .%. Preferably, the gel composition may comprise a viscosity increasing agent, a hydrogen bond gelling agent, and an ionic bond gelling agent, each independently present in the gel composition in the range of from about 0.5% to about 2% by weight. wt.%. Preferably, the gel composition may comprise a viscosity increasing agent, a hydrogen bond gelling agent, and an ionic crosslinking gelling agent, each independently present in the gel composition in the range of from about 1% to about 2% by weight. %.

The viscosity increasing agent may contain one or more of xanthan gum, carboxymethylcellulose, microcrystalline cellulose, methylcellulose, gum arabic, guar gum, lambda carrageenan, or starch. The viscosity increasing agent may preferably contain xanthan gum.

The gel composition may contain xanthan gum in the range of from about 0.2% to about 5% by weight. Preferably xanthan gum may be in the range from about 0.5% to about 3% by weight. Preferably, xanthan gum may be in the range from about 0.5% to about 2% by weight. Preferably xanthan gum may be in the range from about 1% to about 2% by weight.

The gel composition may contain carboxymethyl cellulose in the range from about 0.2% to about 5% by weight. Preferably, the carboxymethyl cellulose may be in the range from about 0.5% to about 3% by weight. Preferably, the carboxymethyl cellulose may be in the range from about 0.5% to about 2% by weight. Preferably, the carboxymethyl cellulose may be in the range from about 1% to about 2% by weight.

The gel composition may contain microcrystalline cellulose in the range of from about 0.2% to about 5% by weight. Preferably, the microcrystalline cellulose may be in the range from about 0.5% to about 3% by weight. Preferably, the microcrystalline cellulose may be in the range from about 0.5% to about 2% by weight. Preferably, the microcrystalline cellulose may be in the range from about 1% to about 2% by weight.

The gel composition may contain methylcellulose in the range of from about 0.2% to about 5% by weight. Preferably, the methylcellulose may be in the range from about 0.5% to about 3% by weight. Preferably, the methylcellulose may be in the range from about 0.5% to about 2% by weight. Preferably, the methylcellulose may be in the range from about 1% to about 2% by weight.

The gel composition may contain gum arabic in the range of from about 0.2% to about 5% by weight. Preferably, the arabic gum may be in the range from about 0.5% to about 3% by weight. Preferably, the arabic gum may be in the range from about 0.5% to about 2% by weight. Preferably, the arabic gum may be in the range from about 1% to about 2% by weight.

The gelled composition may contain guar gum in the range of from about 0.2% to about 5% by weight. Preferably, guar gum may be in the range of about 0.5% to about 3% by weight. Preferably, guar gum may be in the range of about 0.5% to about 2% by weight. Preferably, guar gum may be in the range of about 1% to about 2% by weight.

The gel composition may contain lambda carrageenan in the range of from about 0.2% to about 5% by weight. Preferably, the lambda carrageenan may be in the range from about 0.5% to about 3% by weight. Preferably, the lambda carrageenan may be in the range from about 0.5% to about 2% by weight. Preferably, the lambda carrageenan may be in the range from about 1% to about 2% by weight.

The gelled composition may contain starch in the range of from about 0.2% to about 5% by weight. Preferably, the starch may be in the range from about 0.5% to about 3% by weight. Preferably, the starch may be in the range from about 0.5% to about 2% by weight. Preferably, the starch may be in the range from about 1% to about 2% by weight.

The hydrogen bonding gelling agent may comprise one or more of galactomannan, gelatin, agarose, konjac gum, or agar. The hydrogen bonding gelling agent may preferably contain agar.

The gel composition contains a hydrogen bonding gelling agent in the range of about 0.3% to about 5% by weight. Preferably, the composition contains a hydrogen bonding gelling agent in the range of about 0.5% to about 3% by weight. Preferably, the composition contains a hydrogen bonding gelling agent in the range of about 1% to about 2% by weight.

The gel composition may contain galactomannan in the range of from about 0.2% to about 5% by weight. Preferably, the galactomannan may range from about 0.5% to about 3% by weight. Preferably, the galactomannan may range from about 0.5% to about 2% by weight. Preferably, the galactomannan may be in the range from about 1% to about 2% by weight.

The gelled composition may contain gelatin in the range of from about 0.2% to about 5% by weight. Preferably, the gelatin may be in the range from about 0.5% to about 3% by weight. Preferably, the gelatin may be in the range from about 0.5% to about 2% by weight. Preferably, the gelatin may be in the range from about 1% to about 2% by weight.

The gel composition may contain agarose in the range from about 0.2% to about 5% by weight. Preferably, the agarose may be in the range from about 0.5% to about 3% by weight. Preferably, the agarose may be in the range from about 0.5% to about 2% by weight. Preferably, the agarose may be in the range from about 1% to about 2% by weight.

The gelled composition may contain konjac gum in the range of from about 0.2% to about 5% by weight. Preferably, the konjac gum may range from about 0.5% to about 3% by weight. Preferably, the konjac gum may be in the range from about 0.5% to about 2% by weight. Preferably, the konjac gum may be in the range of about 1% to about 2% by weight.

The gel composition may contain agar in the range of from about 0.2% to about 5% by weight. Preferably, the agar may be in the range from about 0.5% to about 3% by weight. Preferably, the agar may be in the range from about 0.5% to about 2% by weight. Preferably, the agar may be in the range from about 1% to about 2% by weight.

The ionically crosslinking gelling agent may contain low acyl gellan, pectin, kappa carrageenan, iota carrageenan, or alginate. The ionically crosslinking gelling agent may preferably contain low acyl gellan.

The gelled composition may contain an ionically crosslinkable gelling agent in the range of about 0.3% to about 5% by weight. Preferably, the composition contains an ionically crosslinking gelling agent in the range of about 0.5% to about 3% by weight. Preferably, the composition contains an ionically crosslinkable gelling agent in the range of about 1% to about 2% by weight.

The gel composition may contain low acyl gellan in the range of about 0.2% to about 5% by weight. Preferably, the low acyl gellan may be in the range of about 0.5% to about 3% by weight. Preferably, the low acyl gellan may be in the range of about 0.5% to about 2% by weight. Preferably, the low acyl gellan may be in the range of about 1% to about 2% by weight.

The gel composition may contain pectin in the range of from about 0.2% to about 5% by weight. Preferably the pectin may be in the range from about 0.5% to about 3% by weight. Preferably the pectin may be in the range from about 0.5% to about 2% by weight. Preferably the pectin may be in the range from about 1% to about 2% by weight.

The gel composition may contain kappa-carrageenan in the range of from about 0.2% to about 5% by weight. Preferably, kappa-carrageenan may range from about 0.5% to about 3% by weight. Preferably, kappa carrageenan may be in the range of about 0.5% to about 2% by weight. Preferably, kappa carrageenan may be in the range of about 1% to about 2% by weight.

The gel composition may contain iota-carrageenan in the range of from about 0.2% to about 5% by weight. Preferably, iota-carrageenan may be in the range from about 0.5% to about 3% by weight. Preferably, iota-carrageenan may be in the range from about 0.5% to about 2% by weight. Preferably, iota-carrageenan may be in the range from about 1% to about 2% by weight.

The gel composition may contain alginate in the range of from about 0.2% to about 5% by weight. Preferably, the alginate may be in the range from about 0.5% to about 3% by weight. Preferably, the alginate may be in the range from about 0.5% to about 2% by weight. Preferably, the alginate may be in the range from about 1% to about 2% by weight.

The gel composition may contain a hydrogen bonding gelling agent and an ionic crosslinking gelling agent in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain a hydrogen bonding gelling agent and an ionic bonding gelling agent in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a hydrogen bonding gelling agent and an ionic bonding gelling agent in a ratio of about 1:1.

The gel composition may contain a hydrogen bonding gelling agent and a viscosity increasing agent in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may comprise a hydrogen bonding gelling agent and a viscosity increasing agent in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a hydrogen bonding gelling agent and a viscosity increasing agent in a ratio of about 1:1.

The gel composition may contain an ionically crosslinking gelling agent and a viscosity increasing agent in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain an ionically crosslinking gelling agent and a viscosity increasing agent in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain an ionically crosslinking gelling agent and a viscosity increasing agent in a ratio of about 1:1.

The gelled composition may contain gelling agents and an alkaloid compound in a ratio of from about 3:1 to about 1:3. Preferably, the gel composition may contain gelling agents and alkaloid compound in a ratio of from about 2:1 to about 1:2. Preferably, the gel composition may contain gelling agents and alkaloid compound in a ratio of about 1:1.

The gel composition may contain a viscosity increasing agent and an alkaloid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a viscosity increasing agent and an alkaloid compound in a ratio of from about 1:1 to about 1:3. Preferably, the gel composition may contain a viscosity increasing agent and an alkaloid compound in a ratio of about 1:2.

The gel composition may contain an alkaloid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain an alkaloid compound and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain an alkaloid compound and water in a ratio of about 1:10.

The gel composition may contain the alkaloid compound and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain an alkaloid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain the alkaloid compound and glycerol in a ratio of about 1:36.

The gel composition may contain gelling agents and nicotine in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain gelling agents and nicotine in a ratio of from about 2:1 to about 1:2. Preferably, the gel composition may contain gelling agents and nicotine in a ratio of about 1:1.

The gel composition may contain a viscosity increasing agent and nicotine in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a viscosity increasing agent and nicotine in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a viscosity increasing agent and nicotine in a ratio of about 1:2.

The gel composition may contain nicotine and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain nicotine and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain nicotine and water in a ratio of about 1:10.

The gel composition may contain nicotine and glycerin in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain nicotine and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain nicotine and glycerol in a ratio of about 1:36.

The gel composition may contain gelling agents and glycerin in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain gelling agents and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain gelling agents and glycerol in a ratio of about 1:36.

The gel composition may contain a viscosity increasing agent and glycerin in a ratio of about 1:90 to about 1:40. Preferably, the gel composition may contain a viscosity increasing agent and glycerin in a ratio of from about 1:80 to about 1:65. Preferably, the gel composition may contain gelling agents and glycerin in a ratio of about 1:73.

The gel composition may contain gelling agents and cannabinoid compound in a ratio of about 3:1 to about 1:3. Preferably, the gel composition may contain gelling agents and cannabinoid compound in a ratio of from about 2:1 to about 1:2. Preferably, the gel composition may contain gelling agents and cannabinoid compound in a ratio of about 1:1.

The gel composition may contain a viscosity increasing agent and a cannabinoid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a viscosity increasing agent and a cannabinoid compound in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a viscosity increasing agent and a cannabinoid compound in a ratio of about 1:2.

The gel composition may contain a cannabinoid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain a cannabinoid compound and water in a ratio of about 1:8 to about 1:12. Preferably, the gel composition may contain a cannabinoid compound and water in a ratio of about 1:10.

The gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:50 to about 1:25. Preferably, the gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain a cannabinoid compound and glycerol in a ratio of about 1:36.

The gelled composition may contain gelling agents and both an alkaloid compound and a cannabinoid compound in a ratio of from about 3:1 to about 1:3. Preferably, the gel composition may contain gelling agents and both an alkaloid compound and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain gelling agents and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1.

The gel composition may contain a viscosity increasing agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1 to about 1:5. Preferably, the gel composition may contain a viscosity increasing agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain a viscosity increasing agent and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:2.

The gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of about 1:5 to about 1:20. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of from about 1:8 to about 1:12. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and water in a ratio of about 1:10.

The gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of from about 1:50 to about 1:25. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of about 1:40 to about 1:30. Preferably, the gel composition may contain both an alkaloid compound and a cannabinoid compound and glycerol in a ratio of about 1:36.

The gel composition may further contain a divalent cation. Preferably the divalent cation contains calcium ions such as calcium lactate in solution. Divalent cations (such as calcium ions) can assist in gelling compositions that contain gelling agents, such as, for example, an ionically crosslinking gelling agent. The ionic effect can promote gel formation. The divalent cation may be present in the gel composition in the range of about 0.1 to about 1% by weight, or about 0.5% by weight.

The gel composition may further contain an acid. The acid may include a carboxylic acid. The carboxylic acid may contain a ketone group. Preferably, the carboxylic acid may contain a ketone group having less than about 10 carbon atoms, or less than about 6 carbon atoms, or less than about 4 carbon atoms, such as levulinic acid or lactic acid. Preferably this carboxylic acid has three carbon atoms (eg lactic acid). Lactic acid surprisingly improves the stability of the gel composition even when compared to similar carboxylic acids. The carboxylic acid may promote gel formation. The carboxylic acid can reduce the change in the concentration of the alkaloid compound, or the concentration of the cannabinoid compound, or both the concentration of the alkaloid compound and the cannabinoid compound in the gel composition during storage. The carboxylic acid can reduce the change in nicotine concentration in the gel composition during storage.

The gel composition may contain carboxylic acid in the range of from about 0.1% to about 5% by weight. Preferably, the carboxylic acid may be in the range from about 0.5% to about 3% by weight. Preferably, the carboxylic acid may be in the range from about 0.5% to about 2% by weight. Preferably, the carboxylic acid may be in the range from about 1% to about 2% by weight.

The gel composition may contain lactic acid in the range of from about 0.1% to about 5% by weight. Preferably lactic acid may be in the range from about 0.5% to about 3% by weight. Preferably lactic acid may be in the range from about 0.5% to about 2% by weight. Preferably lactic acid may be in the range from about 1% to about 2% by weight.

The gel composition may contain levulinic acid in the range of from about 0.1% to about 5% by weight. Preferably, levulinic acid may range from about 0.5% to about 3% by weight. Preferably, levulinic acid may range from about 0.5% to about 2% by weight. Preferably, levulinic acid may be in the range from about 1% to about 2% by weight.

The gel composition may contain carboxylic acid and alkaloid compound in a ratio of from about 2:1 to about 1:2. Preferably, the gel composition may contain carboxylic acid and alkaloid compound in a ratio of from about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain carboxylic acid and alkaloid compound in a ratio of about 1:1.

The gel composition may contain carboxylic acid and nicotine in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain carboxylic acid and nicotine in a ratio of from about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain carboxylic acid and nicotine in a ratio of about 1:1.

The gel composition may contain a carboxylic acid and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and a cannabinoid compound in a ratio of about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain carboxylic acid and cannabinoid compound in a ratio of about 1:1.

The gel composition may contain a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of from about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain a carboxylic acid and both an alkaloid compound and a cannabinoid compound in a ratio of about 1:1.

The gel composition may contain carboxylic acid and viscosity increasing agent in a ratio of about 2:1 to about 1:2. Preferably, the gel composition may contain carboxylic acid and viscosity increasing agent in a ratio of from about 1:1.5 to about 1.5:1. Preferably, the gel composition may contain carboxylic acid and viscosity increasing agent in a ratio of about 1:1.

The gel composition may contain carboxylic acid and gelling agents in a ratio of about 2:1 to about 1:4. Preferably, the gel composition may contain carboxylic acid and gelling agents in a ratio of about 1:1 to about 1:3. Preferably, the gel composition may contain carboxylic acid and gelling agents in a ratio of about 1:2.

The gel composition may contain carboxylic acid and glycerol in a ratio of about 1:70 to about 1:30. Preferably, the gel composition may contain carboxylic acid and glycerol in a ratio of from about 1:60 to about 1:50. Preferably, the gel composition may contain carboxylic acid and glycerol in a ratio of about 1:55.

The gel composition may contain carboxylic acid and water in a ratio of about 1:30 to about 1:5. Preferably, the gel composition may contain carboxylic acid and water in a ratio of about 1:20 to about 1:10. Preferably, the gel composition may contain carboxylic acid and water in a ratio of about 1:15.

The alkaloid compound or the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound, are included in gelled compositions. The gel composition contains from about 0.5% to about 10 wt.% of an alkaloid compound, or from about 0.5% to about 10 wt.% of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of from about 0, 5% to about 10 wt.%. The gel composition may contain from about 0.5% to about 5% by weight of an alkaloid compound, or from about 0.5% to about 5% by weight of a cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in a total amount of about 0 .5% to about 5 wt.%. Preferably, the gel composition contains from about 1% to about 3% by weight of an alkaloid compound, or from about 1% to about 3% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of from about 1% to about 3 wt.%. The gel composition may preferably contain from about 1.5% to about 2.5% by weight of an alkaloid compound, or from about 1.5% to about 2.5% by weight of a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound in a total amount of from about 1.5% to about 2.5 wt.%. The gel composition may preferably contain about 2% by weight of an alkaloid compound, or about 2% by weight of a cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in a total amount of about 2% by weight. The alkaloid compound component of the gel formulation may be the most volatile component of the gel formulation. In some aspects, water may be the most volatile component of the gel formulation, and the alkaloid compound component of the gel formulation may be the second most volatile component of the gel formulation. The cannabinoid compound component of the gel formulation may be the most volatile component of the gel formulation. In some aspects, water may be the most volatile component of the gel formulation, and the alkaloid compound component of the gel formulation may be the second most volatile component of the gel formulation.

Preferably, the nicotine is contained in gel-like compositions. Nicotine may be added to the composition as a free base or as a salt. The gel composition contains from about 0.5% to about 10 wt.% nicotine or from about 0.5% to about 5 wt.% nicotine. Preferably, the gel composition contains from about 1% to about 3% by weight nicotine, or from about 1.5% to about 2.5% by weight nicotine, or about 2% by weight nicotine. The nicotine component of the gel formulation may be more of a volatile component of the gel formulation. In some aspects, water may be the most volatile component of the gel formulation and the nicotine component of the gel formulation may be the second most volatile component of the gel formulation.

In embodiments where agar is used as the hydrogen bonding gelling agent, the gel composition contains 0.2 to 5 percent by weight, preferably 0.5 to 2 percent by weight, of agar. Preferably, this gelled composition may contain 0.2 to 5 percent by weight, preferably 0.5 to 2 percent by weight, of an ionically crosslinking gelling agent such as low acyl gellan or alginate. Preferably, this gel composition may contain from 0.2 to 5 percent by weight, preferably from 0.5 to 2 percent by weight of a viscosity increasing agent such as xanthan gum. Preferably the gel further comprises 0.1 to 2 wt % alkaloid compound, or 0.1 to 2 wt % cannabinoid compound, preferably the gel further comprises 0.1 to 2 wt % alkaloid compound, or 0.1 up to 2 percent by weight of the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in a total amount of 0.1 to 2 percent by weight. Preferably, the gel further contains 0.1 to 2 weight percent nicotine. Preferably, the gel further contains 70 percent to 80 percent by weight (or 70 to 75 percent by weight) of glycerol. Preferably the gel composition further contains divalent cations such as calcium. In specific embodiments, the remainder of the gel contains water and optional flavors. Preferably, the gel composition further comprises an acid or carboxylic acid, such as lactic acid, in an amount of from about 0.5% to about 2.5% by weight.

In embodiments where low acyl gellan is used as the ionically crosslinking gelling agent, the gel composition contains 0.2 to 5 percent by weight, preferably 0.5 to 2 percent by weight, low acyl gellan. Preferably, this gelled composition may contain from 0.2 to 5 percent by weight, preferably from 0.5 to 2 percent by weight, of a gelling agent that provides crosslinking by hydrogen bonds, such as agar. Preferably, this gel composition may contain from 0.2 to 5 percent by weight, preferably from 0.5 to 2 percent by weight of a viscosity increasing agent such as xanthan gum. Preferably, the gel further contains 0.1 to 2 percent by weight of an alkaloid compound, or 0.1 to 2 percent by weight of a cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in a total of 0.1 to 2 percent by weight . Preferably, the gel further contains 0.1 to 2 weight percent nicotine. Preferably, the gel further contains 70 percent to 80 percent by weight (or 70 to 75 percent by weight) of glycerol. Preferably the gel composition further contains divalent cations such as calcium. In specific embodiments, the remainder of the gel contains water and optional flavors. Preferably, the gel composition further comprises an acid or carboxylic acid, such as lactic acid, in an amount of from about 0.5% to about 2.5% by weight.

The gel composition may contain: from about 1.5% to about 2.5% by weight of an alkaloid compound, or from about 1.5% to 2.5% by weight of a cannabinoid compound, or both the alkaloid compound and the cannabinoid compound in total from about 1.5% to 2.5 wt.%; from about 70% to about 75 wt.% glycerol; from about 18 to about 22 wt.% water; from about 0.5% to about 2 wt.% each of agar, xanthan gum and low acyl gellan; and calcium ions. Each of xanthan gum, agar and low acyl gellan may be present in the gel composition in substantially equal amounts by weight.

The gel composition may contain: from about 1.5% to about 2.5 wt.% nicotine; from about 70% to about 75 wt.% glycerol; from about 18 to about 22 wt.% water; from about 0.5% to about 2 wt.% each of agar, xanthan gum and low acyl gellan and calcium ions. Each of xanthan gum, agar and low acyl gellan may be present in the gel composition in substantially equal amounts by weight.

The gelled composition can be heated (using an aerosol generating device) to vaporize the alkaloid compound or the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound. The gel composition can be heated (using an aerosol generating device) to vaporize the nicotine. Heating the gelled composition may not release the liquid phase.

All scientific and technical terms used in this document have the meanings commonly used in the art, unless otherwise indicated. The definitions provided in this document are intended to facilitate understanding of certain terms commonly used in this document.

As used herein, the singular forms include embodiments with reference to the plural, unless the content clearly implies otherwise.

As used herein, the conjunction "or" is generally used in its meaning, including "and/or", unless the content clearly implies otherwise. The term "and/or" means one or all of the listed elements or a combination of any two or more of the listed elements.

As used herein, the words "have", "having", "include", "including", "comprise", "comprising", or the like, are used in their broadest sense and generally mean "including, but not limited to ". It should be understood that the expressions "consisting essentially of", "consisting of", etc., are in the category of "comprising", etc.

The words "preferred" and "preferably" refer to embodiments of the present invention that may provide certain advantages under certain conditions. However, other embodiments may also be preferred under the same or different circumstances. Furthermore, the description of one or more preferred embodiments is not meant to imply that other embodiments are not applicable, and is not intended to exclude other embodiments from the scope of the present invention, including the claims.

Further reference will be made to the drawings, which depict one or more aspects described in the present invention. However, it should be understood that other aspects not depicted in the drawings are within the scope and scope of the present invention. Like numbers used in the figures refer to the same components, steps, and the like. However, it will be understood that the use of a number to designate a component in a given figure is not intended to limit a component in another figure labeled with the same number. In addition, the use of different numbers to designate components in different figures is not intended to indicate that components with different numbers cannot be the same as, or similar to, components with different numbers. The figures are presented for the purpose of illustration and not limitation. The schematic representations shown in the figures are not necessarily drawn to scale.

In FIG. 1 shows a schematic sectional view of an aerosol generating device and a schematic side view of an aerosol generating article that can be inserted into the aerosol generating device.

In FIG. 2 is a schematic sectional view of the aerosol generating device shown in FIG. 1 and a schematic side view of the product shown in FIG. 1 inserted into an aerosol generating device.

In FIG. 3 is a schematic sectional view of an embodiment of an aerosol generating article.

In FIG. 1-2 shows an example of an aerosol generating article 100 and an aerosol generating device 200. Aerosol generating article 100 has a proximal or mouth end 101 and a distal end 103. FIG. 2, the distal end 103 of the aerosol generating article 100 is placed in the reservoir 220 of the aerosol generating device 200. The aerosol generating device 200 includes a housing 210 defining a reservoir 220 that is configured to receive the aerosol generating article 100. The aerosol generating device 200 also includes a heating element 230 which defines a cavity 235 configured to receive the aerosol generating article 100, preferably by means of an interference fit. Heating element 230 may include an electrically resistive heating component. In addition, the device 200 includes a power supply 240 and control electronics 250 that cooperate to control heating of the heating element 230.

The heating element 230 may heat the distal end 103 of the aerosol generating article 100, which includes a tubular element 600 (not shown). In this example, the tubular element 600 contains a gel composition 500 containing nicotine. Heating the aerosol generating article 100 causes the tubular member 600 containing the gel composition 500 to generate an aerosol containing nicotine that can be transferred outwardly from the aerosol generating article 100 at the proximal end 101.

In FIG. 1-2 does not show the exact heating mechanism.

In some examples, the heating mechanism may be implemented by conduction, where heat is transferred from the heating element 230 of the aerosol generating device 200 to the aerosol generating article 100. This can easily happen when the aerosol generating article 100 is located in the reservoir 220 of the aerosol generating device 200 and the distal end 103 (which is preferably the end where the tubular member 600 containing the gel composition 500 is located), and thus the article The aerosol generating unit 100 is in contact with the heating element 230 of the aerosol generating apparatus 200. In specific examples, the heating element includes a heating plate that protrudes from the aerosol generating device 200 and is suitable for penetrating the aerosol generating article 100 to make direct contact with the gel composition 500 of the tubular element 600.

In this example, the heating mechanism is under the influence of induction, where the heating element emits radio-magnetic radiation, which is absorbed by the tubular element when the aerosol generating product 100 is located in the reservoir 220 of the aerosol generating device 200.

In FIG. 3 shows an embodiment of an aerosol generating article 100 comprising a wrapper 110 and a fluid guide 400.

The fluid guide 400 has a proximal end 401, a distal end 403, and an inner longitudinal passage 430 from the distal end 403 to the proximal end 401. The inner longitudinal passage 430 has a first portion 410 and a second portion 420. The first portion 410 defines the first portion of the passage 430, which extends from the distal end 413 of the first part 410 to the proximal end 411 of the first part 410. The second part 420 forms a second part of the channel 430, which extends from the distal end 423 of the second part 420 to the proximal end 421 of the second part 420. The first part 410 of the channel 430 has a narrowed area from the distal end 413 to the proximal end 411 of the first portion 410 to cause acceleration of a fluid, such as air, through this first portion 410 of the inner longitudinal channel 430 when a negative pressure is applied to the proximal end 101 of the aerosol generating article 100. The cross-sectional area of the first part 410 of the inner longitudinal channel 430 tapers from the distal end 413 to the proximal end 411 of the first part 410. environment. In the second part 420 of the inner longitudinal channel 430, the fluid may slow down.

The wrapper 110 defines an open proximal end 101 of the aerosol generating article 100 and a distal end 103. A tubular member 600 containing the gel composition 500 is located at the distal end 103 of the aerosol generating article 100. The aerosol generating article 100 includes an end plug at its distal end 103. The end plug is located on the far side of the tubular 600. The end plug contains a material with a high draw resistance, thereby displacing fluid to enter the aerosol generating article 100 through openings 150 while applying negative pressure to the proximal end 101 of the aerosol generating article 100. The aerosol generated or released from the nicotine-containing tubular 600, when heated, can enter the cavity 140 in the aerosol generating article, downstream of the tubular 600, to be transferred through the internal longitudinal channel 430.

The apertures 150 extend through the wrap 110. At least one aperture 150 is in communication with an outer longitudinal channel 440 formed between the outer surface of the fluid guide 400 and the inner surface of the wrap 110. A seal is formed between the fluid guide 400 and the wrap 110 in place between the holes 150 and the proximal end 101.

When negative pressure is applied to the proximal end 101 of the aerosol generating article 100, fluid enters the openings 150, flows through the outer longitudinal channels 440 into the cavity 140 and into the tubular element 600 containing the gel-like composition, where the fluid can trap the aerosol when the tubular element 600 containing the gel composition is heated. The fluid then flows through the inner longitudinal channel 430 and through the proximal end 101 of the aerosol generating article 100. As the fluid flows through the first portion 410 of the inner longitudinal channel 430, the fluid accelerates. As the fluid flows through the second portion of the inner longitudinal channel 430, the fluid slows down. In the depicted embodiment, the wrap 110 defines a proximal cavity 130 between the proximal end 401 of the fluid guide 400 and the proximal end 101 of the product 100, which can serve to slow down the fluid before exiting the mouth end 101.

EXAMPLES

Table 1 describes the formulations of the gel composition that were formulated.

Table 1:

Example Compound
(w/w) Shape change at RH environment 1 0.5% low acyl gellan
0.5% guar gum
2% nicotine
0.5% calcium
1.3% levulinic acid
95.2% glycerin Yes 2 0.5% low acyl gellan
0.5% guar gum
2% nicotine
0.5% calcium
1.3% levulinic acid
85.2% glycerin
10% water Yes 3 1% low acyl gellan
1% agar
1% xanthan
2% nicotine
1% calcium
1.3% levulinic acid
92.7% glycerin Minor 4 1% low acyl gellan
1% xanthan
1% agar
2% nicotine
0.5% calcium
1.3% levulinic acid
20% water
72.7% glycerin No 5 2% low acyl gellan
1% xanthan
2% nicotine
0.5% calcium
1.3% levulinic acid
20% water
72.7% glycerin No 6 1.5% low acyl gellan
1.5% high acyl gellan
2% nicotine
1% calcium
1.3% levulinic acid
72.7% glycerin No 7 1% alginate
1% xanthan
1% agar
2% nicotine
1% calcium
1.3% levulinic acid
20% water
72.7% glycerin No 8 3% low acyl gellan
2% nicotine
1% calcium
1.3% levulinic acid
20% water
72.7% glycerin No 9 1% agar
2% nicotine
1.3% levulinic acid
30% water
65.7% glycerin -

Indentation hardness test

Measurements were made using an Anton Parr PNR12 penetrometer and a quarter-cone plate. Samples (gel compositions) were loaded under the needle and manually aligned with the top surface of the sample. The tip of the needle shadow on the sample was brought into contact with the needle. At least three measurements were taken for each sample. The average penetration distance for each gel was measured.

Example 1 had a penetration distance of about 7.5 mm.

Example 2 had a penetration distance of about 7.7 mm.

Example 3 had a penetration distance of about 7.0 mm.

Example 4 had a penetration distance of about 3.8 mm.

Example 9 had a penetration distance of about 5.0 mm.

The greater the penetration distance, the softer the gel composition.

Change in the weight of the gel composition over time

Several exemplary formulations were weighted over 45 days at various relative humidity levels. The stable gel composition essentially retains its original weight for 45 days.

Example 4 was weighed after 45 days at three relative humidity levels (10%, 60% and 70%). At a relative humidity of 60%, this gel composition gained about 10% of its weight within 45 days, with almost all of the weight gain occurring in the first 5 days. At a relative humidity of 10%, this gel composition lost about 15% of its weight within 45 days, with almost all of the weight loss occurring in the first 5 days. At a relative humidity of 70%, this gel composition gained about 25% of its weight within 45 days, with almost all of the weight gain occurring in the first 5 days. At all three levels of relative humidity (10%, 60% and 70%) no liquid phase was observed.

Example 2 was weighed after 45 days at three levels of relative humidity (10%, 60% and 70%). At a relative humidity of 60%, this gel composition gained about 15% of its weight within 45 days, with almost all of the weight gain occurring in the first 5 days. At a relative humidity of 10%, this gel composition lost about 5% of its weight within 45 days, with almost all of the weight loss occurring in the first 5 days. At a relative humidity of 70%, this gel composition gained about 45% of its weight within 45 days, with almost all of the weight gain occurring in the first 5 days.

Additional examples

Table 2 describes the formulations of the gel composition that were formulated.

Table 2: Example Compound
(w/w) 10 1% low acyl gellan
1% xanthan
1% agar
2% nicotine
0.5% calcium
1.3% lactic acid
20% water
72.7% glycerin eleven 1% alginate
1% xanthan
1% agar
2% nicotine
0.5% calcium
1.3% lactic acid
20% water
72.7% glycerin 12 2% low acyl gellan
1% xanthan
2% nicotine
0.5% calcium
1.3% lactic acid
20% water
72.7% glycerin 13 1.5% low acyl gellan
1.5% high acyl gellan
2% nicotine
1% calcium
1.3% lactic acid
20% water
72.7% glycerin 14 3% low acyl gellan
2% nicotine
1% calcium
1.3% lactic acid
20% water
72.7% glycerin

Claims (38)

1. Gel-like composition for generating an aerosol, containing: an alkaloid compound, or a cannabinoid compound, or both an alkaloid compound and a cannabinoid compound, wherein the alkaloid compound is selected from the group consisting of nicotine, anatabine, and combinations thereof, wherein the cannabinoid compound is selected from the group consisting of cannabidiol (CBD), tetrahydrocannabinol ( THC), Cannabigerol (CBG), Cannabichromene (CBC), Cannabicyclol (CBL), Cannabivarin (CBV), Tetrahydrocannabivarin (THCV), Cannabidivarin (CBDV), Cannabichromevarin (CBCV), Cannabigerovarin (CBGV), Cannabigerol Monomethyl Ether (CBGM), cannabielsoin (CBE), cannabicitran (CBT) and combinations thereof; from 50 wt.% to 80 wt.% glycerol; from 0.2 wt.% to 5 wt.% gelling agent providing crosslinking through ionic bonds, and the gelling agent providing crosslinking through ionic bonds includes low acyl gellan, pectin, kappa-carrageenan, iota-carrageenan or alginate; from 0.2 wt.% to 5 wt.% of a viscosity increasing agent and / or from 0.2 wt.% to 5 wt.% of a gelling agent that provides crosslinking through hydrogen bonds, while the viscosity increasing agent includes one or more xanthan gum, carboxymethylcellulose, microcrystalline cellulose, methylcellulose, gum arabic, guar gum, lambda carrageenan, or starch, wherein the hydrogen bonding gelling agent comprises one or more of galactomannan, gelatin, agarose, konjac gum, or agar, and lactic acid or levulinic acid. 2. Composition according to claim 1, containing: from 0.5 wt.% to 2.5 wt.% nicotine; from 70 wt.% to 80 wt.% glycerol; from 0.5 wt.% to 5 wt.% gelling agent, providing crosslinking through hydrogen bonds; from 0.5 wt.% to 5 wt.% means to increase the viscosity; from 0.5 wt.% to 5 wt.% gelling agent, providing crosslinking through ionic bonds; And lactic acid or levulinic acid; wherein the composition further comprises divalent ions. 3. Composition according to claim. 1 or 2, containing from 0.5 wt.% to 5 wt.% lactic acid or levulinic acid. 4. The composition according to any one of paragraphs. 1-3, additionally containing calcium ions. 5. The composition according to any one of paragraphs. 1-4, in which each of the agent for increasing the viscosity, the gelling agent providing crosslinking through hydrogen bonds, and the gelling agent providing crosslinking through ionic bonds, is present in the gel composition in an amount of from 0.5 wt.% to 2.5 wt. .%. 6. Composition according to claim 1, containing: from 0.5 wt.% to 2.5 wt.% nicotine; from 70 wt.% to 80 wt.% glycerol; from 0.5 wt.% to 2 wt.% means to increase the viscosity; from 0.5 wt.% to 2 wt.% gelling agent, providing crosslinking through hydrogen bonds; from 0.5 wt.% to 2 wt.% gelling agent, providing crosslinking through ionic bonds; And from 0.5 wt.% to 2.5 wt.% lactic acid; wherein the composition additionally contains from 15 wt.% to 25 wt.% water and divalent ions. 7. The composition according to any one of paragraphs. 1-6 wherein the viscosity increasing agent comprises xanthan gum. 8. The composition according to any one of paragraphs. 1-7, wherein the hydrogen bonding gelling agent comprises agar. 9. The composition according to any one of paragraphs. 1-8, wherein the ionically crosslinking gelling agent contains low acyl gellan. 10. Composition according to claim 1, containing: from 1.5 wt.% to 2.5 wt.% nicotine; from 70 wt.% to 75 wt.% glycerol; from 18 wt.% to 22 wt.% water; from 0.5 wt.% to 2 wt.% agar; from 0.5 wt.% to 2 wt.% xanthan gum; And from 0.5 wt.% to 2 wt.% gellan with a low content of acyl; from 0.5 wt.% to 2.5 wt.% lactic acid. 11. Composition according to claim 10 containing calcium ions. 12. The use of a gel-like composition according to any one of paragraphs. 1-11 with an aerosol generating device for heating the gelled composition to vaporize the alkaloid compound, or the cannabinoid compound, or both the alkaloid compound and the cannabinoid compound.