RU2706333C1 - Ointment for wound healing - Google Patents

Abstract

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention refers to pharmaceutical industry, namely to an ointment for treating wounds. Ointment for treating wounds, including herbal substances, beeswax, pork fat, wherein vegetal origin substances contains ground common herb mixture of common St. John's wort, heath speedwell, burdock leaves, allheal, white lily leaves and stems, dog's tongue with weight ratio of ingredients of 1:1:1:1:1:0.5 respectively, and additionally contains egg oil, grape seed oil in certain proportions.

EFFECT: ointment described above has a wide spectrum of therapeutic action, enables reducing the length of wound healing without complications and by-effects.

1 cl, 1 tbl

Description

The invention relates to medicine, in particular to therapeutic ointments of anti-inflammatory, regenerating, wound healing, anti-burn, antimicrobial effects with biostimulating properties and can be used in surgery and traumatology, in dermatology, in plastic surgery and cosmetology.

Known ointment for the treatment of purulent and infected wounds of various etiologies, containing fir oil, propolis, conifers, spermaceti and penguin fat in a mass ratio of components 3-7: 0.5-1.5: 0.5-1.5: 1, 5-2.5: 7-15, respectively (RF patent No. 2058776, publ. 04/27/96).

The disadvantages of this ointment are the presence in the formulation of spermaceti and penguin fat, the availability and raw materials of which are limited, as well as a wide range of therapeutic effects on the body.

Known ointment for treating wounds, containing as an active ingredient pumpkin seed oil and a base selected from polyethylene glycol 1500 (PEG-1500) and its mixture with polyethylene glycol 400 (PEG-400), taken in an amount up to 2% of the total weight of the composition, the following components, wt. %: pumpkin seed oil 28-30, PEG-1500 or its mixture with PEG-400 70-72, additionally containing an antimicrobial agent selected from the group consisting of dimexide, furagin, chlorhexidine or mixtures thereof, and additionally containing trimecaine (RF patent No. 2432156, publ. 10/27/2011).

The disadvantages of the known ointments are an insufficient range of therapeutic activity, the need to achieve the antibacterial effect of the inclusion of additional synthetic antimicrobial agents in the ointment, as well as the mandatory preliminary sterilization of all ingredients.

Known ointment for the treatment of wounds containing the following components, wt. %: coniferous resin (resin of pine or spruce) - 7.0-8.0; beeswax - 6.7-7.3; butter - 6.5-7.5; vegetable oil - 6.5-7.5; interior fat (pork or beef or goose or sheep) - 19.0-22.0; propolis - 0.5-1.0; onion turnip - the rest (RF patent No. 2139708, publ. 20.10.99).

One of the disadvantages of this ointment is the limited range of therapeutic effects and the presence of inaccessible components in the formulation.

As a prototype, an ointment for treating wounds was selected, containing gum, beeswax, cow’s oil, sea buckthorn oil, pork fat and plant-derived substances selected from the group: aloe extract, plantain extract, succession extract, rose hip extract, hypericum oil, linseed oil, calendula oil, burdock oil, chamomile oil or propolis in the following ratio, wt. %: gum - 5.0-15.0, beeswax - 5.0-10.0, cow oil - 10.0-20.0, sea buckthorn oil - 5.0-10.0, substances of plant origin - 3 , 0-5.0, pork fat - the rest (RF Patent No. 2325175, publ. 05.27.2011).

The disadvantages of the known ointments are a limited range of therapeutic effects of the ointment, the known composition does not allow to maintain high quality ointments for a long time.

A patent information search showed that individual components of the ointment or combinations thereof are found in known therapeutic ointments for this purpose, however, drugs in the form of ointments for treating wounds in the proposed combination of ingredients and their ratio in the composition of the claimed ointment were not identified.

Based on the above prior art, when creating ointments for treating wounds, the problem is to achieve multifaceted action: antiseptic, necrolytic, anti-inflammatory, regenerative and wound healing, as well as pronounced prolonged action, which will provide maximum therapeutic efficacy with minimal adverse reactions.

The development of a new composition of the ointment for the treatment of wounds with anti-inflammatory, analgesic and wound healing effects based on natural components suitable for treating wounds regardless of the phase of the wound process, allows us to solve the above problem.

The technical result consists in the creation of ointments with an expanded spectrum of therapeutic effects, with increased therapeutic efficacy, with a long shelf life and ease of use.

An additional result is the expansion of the range of domestic therapeutic ointments that do not have a pronounced irritating side effect. All the components used in the composition of the ointment are not scarce, available, and perhaps offer for industrial production.

The proposed combination of the components of the ointment in an experimentally selected, optimal amount, provides the claimed therapeutic effect. Other ratios of the components taken do not allow achieving the necessary therapeutic effect in a short time.

It is proposed, as in the prototype, to use in the composition of the ointment substances of plant origin, beeswax, pork fat.

The ointment for the treatment of wounds in the inventive composition was developed for the first time.

The essence of the claimed invention lies in the fact that the ointment for the treatment of wounds, including substances of plant origin, beeswax, pork fat, according to the invention, as substances of plant origin contains a ground herbal mixture of perforated St. John's wort, medicinal veronica, burdock leaves, blackheads, leaves and stems white lily, black root with a mass ratio of ingredients 1: 1: 1: 1: 1: 0.5, respectively, and additionally contains egg oil, grape seed oil in the following ratio to components, wt. %:

ground herbal mixture 20-30 yellow beeswax 10-15 egg butter 3-5 grape seed oil 2-3 interior lard rest

A causal relationship between the set of essential features and the technical result provided by the invention is as follows: the use of the active phase based on an herbal mixture of perforated St. John's wort, Veronica officinalis, burdock leaves, Chernogolovka, leaves and stems of white lily, black root, which have anti-inflammatory, hemostatic, antimicrobial, wound healing effect, enhances the action of herbs with each other, and the combination of the herbal mixture with the fat phase of maz and, including egg oil, grape seed oil, interior lard, beeswax, can provide a high therapeutic effect by reducing the healing time of wounds of various etiologies without side effects; and also expand the range of domestic medicines in the form of ointments of anti-inflammatory, wound healing, anti-burn and antimicrobial effects with an accessible stable composition of products of natural origin, without the use of chemical or special synthetic additives.

The given quantitative intervals of the ratio of the components that make up the ointment were determined experimentally, are optimal and provide maximum effectiveness of the ointment. Deviation from the proposed ratio of the components is impractical, since the therapeutic effect is reduced.

The composition of the claimed ointment for the treatment of wounds includes ten components.

The active phase of the ointment is a crushed herbal mixture of six herbs, selected experimentally in such a way as to enhance the effect of each other.

The composition of the herbal mixture includes St. John's wort (Hypericum perforatum L.), Veronica officinalis (Veronica officinalis L.), burdock leaves (Arctium lappa L.), blackhead (Prunella vulgaris L.), leaves and stems of white lily (Lilium candidum L. ), black root (Cynoglossum officinale L.).

The fat phase of the ointment contains yellow beeswax, egg oil, grape seed oil and interior lard.

The crushed herbal mixture is introduced into the molten fat phase by thoroughly mixing until smooth, extraction, followed by filtration.

The ointment has a color from light yellow to yellow. The ointment is obtained a soft consistency, homogeneous and odorless. The ointment is characterized by sufficient viscosity, density and stickiness. Ointment is well fixed on the surface of the skin and mucous membranes, hygienic.

Indications for the use of ointments: deep wounds, superficial wounds, trophic ulcers, burns 1-2 degrees. It is applied externally, without restrictions during pregnancy and lactation. Contraindication - increased individual sensitivity to individual components of the drug.

In the composition of the claimed ointment for the treatment of wounds, black root due to toxicity is taken in half in a smaller amount compared to the other five herbs. The dosage is established experimentally, is optimal to achieve the desired therapeutic effect, is harmless.

Herbs in the claimed composition of the ointment are selected so that everyone has anti-inflammatory, analgesic, wound healing, antimicrobial, hemostatic, anti-burn, regenerating, anti-toxic, tonic effect and regulate the cellular immunity system.

Hypericum perforatum L. (Hypericum perforatum L.) contains tocopherols, flavanoids, essential oil hypericin, tannins, vitamin P and PP, vitamins C, carotene, macro and microelements, nicotinic acid, azulene, provitamin A, invert sugar. Active substances: quercetin, hyperoside, quercitrin, isocvercitrin, rutin, hypericinol, tannins, pseudohypericin, carotene, resins, essential oil, nicotinic and ascorbic acids, phytoncides. Tocopherols are necessary for protection against free radicals, flavono compounds allow the use of St. John's wort as antibacterial, antiseptic, analgesic, wound healing and regenerating agent. Carotene promotes the renewal of skin cells and protects against viruses and bacteria, tannins help cleanse wounds from infection, reduce inflammation, accelerate healing, vitamin C helps to restore and renew tissues, supports skin turgor, and prevents cells from degenerating into atypical ones. Hyperoside and rutin strengthen the walls of blood vessels, phytoncides - plant antibiotics with a powerful antimicrobial effect, are able to suppress Staphylococcus aureus with purulent skin diseases, abscesses, phlegmons, burns.

Veronica officinalis (Veronica officinalis L.) in its composition has ascorbic acid, bitterness, carotene, tannins and glycosides and is one of the best wound healing and disinfectants, it stops blood, effectively fights inflammation, and eliminates pain. As part of a lot of trace elements, there are alkaloids, citric, malic, lactic acids. Use Veronica officinalis for the treatment of ulcers, ulcers, boils, burns, stopping bleeding. It has anti-inflammatory, analgesic and antitoxic effects. Carotene, tannins, ascorbic acid, bitterness, glycosides, destroy microbes and, together with malic, lactic, citric acids and trace elements, have an antipruritic effect, which is very important in the process of wound healing. The chemical composition of Veronica contains many carbohydrates, which are the energy potential for skin cells, many organic and phenol carboxylic acids, sterols, saponins, choline, coumarins, fatty oils, bioflavonoids. Aucubin is identical to that found in plantain, with antiseptic, antimicrobial and anti-inflammatory effects.

Burdock (Arctium lappa L.) contains more than 12% protein, essential oils up to 0.17%, fat-like substances 0.82%, tannins and bitter substances, polysaccharides, inulin up to 45%, ascorbic acid. Thanks to which, burns, frostbite can be treated, and the growth of tumors slows down. Phytoncides, flavonoids, palmitic, stearic acid, carbohydrate C ₂₆ H ₅₄ , sitosterol and stigmasterol, fatty oil up to 20%, consisting of linoleic glycerides 58.5% and oleic 19.1% acids, mucus 0.03 are present in the chemical composition of burdock. % The plant has antitoxic, wound healing, analgesic, hemostatic, anti-inflammatory, antibacterial and tumor growth retardant effects.

The composition of Chernogolovka (Prunella vulgaris L.) contains tannins of 15.3%, resins, essential oil, triterpene saponins, vitamin C, flavonoids - 0.3%, quercitrin - 0.5%, which cause anti-inflammatory, antimicrobial, hemostatic effect . Triterpene saponins in the form of ursolic and delenic acids, fatty oil in an amount of 3-16%, vitamin K, hyperoside, beturic acid, and dolphinidin are also present in the blackhead. Chernogolovka has a wide spectrum of antimicrobial activity against shigella, including E. coli strains. It also has an antifungal effect, anti-inflammatory and tonic effect, a powerful inhibitory effect on free radical oxidation, and has antiviral activity. Use grass for wound healing, anesthesia, treatment of burns.

White lily (Lilium candidum L.) is widely used in cosmetology, as it protects and softens the skin, brightens, stabilizes pigmentation, tones and soothes the skin, has a powerful anti-edematous effect against the background of anti-inflammatory, antimicrobial, wound healing, hemostatic, analgesic, anti-burn, disinfectant. Saponins relieve inflammation, lead to normal metabolic processes, regulate and enhance the activity of hormones, contribute to the synthesis of corticosteroids. Flavonoids reduce the fragility of capillaries, strengthen blood vessels, eliminate the inflammatory process and accelerate wound healing, treat burns. Alkaloids increase blood coagulation, reduce pain. Proteins in the composition of white lilies, regulate and normalize the hormonal background, contribute to the formation of muscle cells. Vitamin C is involved in the regulatory-restoration process, providing tissue growth and development, increases capillary permeability, removes free radicals and toxins. Iron promotes the synthesis of hormones, neutralizes pathogenic bacteria. The trace element normalizes and regulates the reproduction of the skin, stabilizes the hormonal background, tannins effectively eliminate the foci of inflammation of the skin and mucous membranes.

Black root (Cynoglossum officinale L.) contains alkaloids cinoglossein, consolidin, tannins, coumarins, cinnamic and fumaric acids, the bitter substance cinoglossoidin, choline, and inulin. The pharmacological properties of black root are determined by its chemical composition. Medicinal black root has analgesic, anti-inflammatory, hemostatic properties.

The fat phase of the claimed ointment includes four components.

Interior lard contains linolenic and linoleic acids, in which there are many unsaturated fatty acids with a melting point of only 25-30 ° C. Interior fat has a pronounced softening and healing properties, its basis is saturated fatty acids, more than 60% of them. The chemical composition determines the improvement of skin tissue nutrition.

Yellow beeswax in the composition of the ointment increases its viscosity and absorbency. The presence of triglycerides in it contributes to the release of oxidized oxygen into the wound, and hence the gentle bactericidal effect and tissue healing. Beeswax nourishes and strengthens the skin. Its chemical composition is close to fats. Composed of free alcohols and various fatty acids. The vitamin A and carotene present in the composition are useful for skin diseases and inhibit the growth of a number of pathogens.

As part of the ointment, wax facilitates the formation of an emulsion and increases its stability, and due to its nature improves absorption.

Thanks to biologically active substances extracted from beeswax, fatty base wax, the ointment has a multifaceted effect. Beeswax also performs a structure-forming function.

Beeswax in combination with vegetable oil contributes to the release of oxygen into the healing wound. Oil provides a bactericidal effect and antimicrobial activity, enhances penetration into biological tissue.

Egg oil has proven itself in wound healing from burns, scars, scars. The lipids contained in egg oil are similar in structure to human skin lipids, quite simply bind to each other and, accordingly, restore the natural barrier. Upon contact with the surface of the skin forms a two-layer structure. In it, the lower layer is hydrophobic, and the upper one is hydrophilic, which helps moisture from outside to enter the horny layer of the skin better and does not allow moisture to evaporate from the inside, which is especially important for burns. Therefore, it is very important that this warm and moist environment, favorable for the multiplication of microorganisms, be neutralized with a strong in its properties herbal mixture and other components of the claimed ointment.

Egg oil stimulates the development of young layers of the epidermis, and since moisture is additionally retained in the skin, coarse scar tissue does not form. A sufficient amount of fat-soluble vitamins A, D, E also contributes to this. This is a synergistic natural antioxidant complex that protects young cells and supports their biological functions, regulates water-salt and electrolyte metabolism in cells, promotes absorption of calcium and phosphorus by cells, strengthens capillary walls, due to the increased concentration of vitamins. Egg oil softens the skin, is quickly absorbed into the tissue, eliminates bleeding cracks, and at the same time dries the wound, creating favorable conditions for healing. A large number of phospholipids is the main building material of cell membranes in living organisms, the basis of the matrix of the stratum corneum, they fix biologically active substances, ensuring their gradual release and deep penetration into the skin.

The grape seed oil used in the composition of the inventive ointment is obtained by cold pressing, therefore, it preserves important biologically active substances, determines the healing regenerating, antioxidant, cytoprotective properties. The oil has a liquid and very light consistency, is characterized by a large amount of vitamin E. It contains the most powerful natural antioxidant - procyanide, which regulates the work of cell membranes, which helps the output of aggressive oxidized radicals. The value of this vegetable oil is high in polyunsaturated fatty acids. Grape seed oil does not clog pores, is easily absorbed into the skin, giving it a natural healthy appearance, and has a pronounced moisturizing effect. Stimulates collagen synthesis, ensuring skin elasticity, normalizes the activity of the sebaceous glands. It has grape seed oil anti-inflammatory, bactericidal, astringent, wound healing, strong regenerating effect on skin cells. Increases skin elasticity and turgor, stimulates blood and lymph flow in the upper layers of the skin, prevents the appearance of pigmentation, is completely absorbed.

The invention is illustrated by the following specific embodiment.

The herbal mixture is prepared from St. John's wort, Veronica officinalis, burdock leaves, Chernogolovka, leaves and stems of white lily and black root, with a mass ratio of ingredients 1: 1: 1: 1: 1: 0.5, respectively, crushed and mixed.

The interior lard in a refractory glassware in a water bath is brought to a boil and boiled over low heat for 7 minutes, constantly stirring with a wooden spoon.

Next, the resulting crushed herbal mixture is introduced into the molten interior lard and thoroughly mixed, simmered over very low heat under a lid, stirring for 60 minutes.

Then it is slightly cooled, carefully filtered and squeezed.

Yellow beeswax is melted in a water bath, mixed with egg oil, thoroughly mixing with a wooden spoon.

Ready filtered herbal mixture is added to the molten mass.

Then simmer over low heat in a water bath for 20 minutes, mixing thoroughly. Grape seed oil is added to the cooled mixture and mixed vigorously. Next, the resulting ointment is packaged.

Store the ointment in a refrigerator at a temperature of 25 ° C.

The inventive ointment is prepared with the following components, wt. %: crushed herbal mixture - 20-30%, yellow beeswax - 10-15%, egg oil - 3-5%, grape seed oil - 2-3%, interior lard - the rest.

The allowable ratio in the herbal mixture of parts is 1: 1: 1: 1: 1: 0.5.

The permissible ratio of grape seed oil is up to 50% of the amount of egg oil.

The permissible ratio of egg oil to beeswax is up to 30%.

The permissible ratio of interior lard to ground herbal mixture is 3: 1.

These quantitative intervals, the ratio of the components are determined experimentally and are optimal for providing a therapeutic effect.

When using other ratios of components of herbs and oils in the composition of the ointment, their biological activity is reduced, the therapeutic effect is significantly reduced and, accordingly, the task of multifaceted action with a wide range of biological activity is not fulfilled.

The test of the claimed ointment was carried out on white outbred mice.

When conducting experimental studies, we complied with the principles and provisions of the Guide for the Care and Use of Laboratory Animals (US NIH, No. 85-23), the international rules "Guide for the Care and Use of Laboratory Animals" (2009), taking into account the Council of Europe Convention on Protection vertebrates used for experiments or other scientific purposes (Strasbourg, 1986).

The table shows the dynamics of the area of the wound surface in the experiment on white outbred mice (cm ² ).

Note: * P <0.05 - significance of differences in the parameters of the study group compared to the control.

The data in the table indicate the biostimulating effect of the ointment and a reduction in the healing time of wounds.

The ointment maintains high quality for a long time, and is also convenient to use due to good fixation and uniform distribution on the skin surface.

The inventive ointment can be used for superficial and deep wounds, trophic ulcers, burns 1-3a degree. Ointment is applied externally, without restrictions during pregnancy and lactation. The treatment of the claimed ointment speeds up the healing time of wounds without complications and side effects.

Claims (2)

An ointment for treating wounds, including substances of plant origin, beeswax, pork fat, characterized in that as substances of plant origin it contains a crushed herbal mixture of St. John's wort, Veronica officinalis, burdock leaves, blackheads, leaves and stems of white lily, black root in a weight ratio ingredients 1: 1: 1: 1: 1: 0.5, respectively, and additionally contains egg oil, grape seed oil in the following ratio, wt. %: ground herbal mixture 20-30 yellow beeswax 10-15 egg butter 3-5 grape seed oil 2-3 interior lard rest