RU2791992C2 - Solubilized apirases, methods and applications - Google Patents

Abstract

FIELD: biotechnology.

SUBSTANCE: invention is a solubilized human apyrase containing modifications: N-terminal deletion, C-terminal deletion and modification of the central region, where the length of the N-terminal deletion is from 30 to 50 amino acids, the length of the C-terminal deletion is from 20 to 40 amino acids, and the modification of the central region includes a deletion of 10 to 15 consecutive amino acids, where the deletion is a deletion of amino acids 193 to 204 relative to the wild-type CD39 sequence according to SEQ ID NO: 1 and where the modification of the central region includes a point mutation involving one, two, three, four or five point mutations relative to the wild-type CD39 sequence according to SEQ ID NO: 1 selected from the group consisting of K71E, N73Q, V95A, G102D, Y104S, T106S, R113M, L149M, V151A, E173D, T229A, L254M, K258R, W263R, E276D, N292Q, R304G, I319T, N327Q, F365SN N371Q, K405N, Y412F, L424Q, H436D, I437N, F439S, G441D, N457Q, P463S and S469R. The invention also relates to a pharmaceutical composition for the treatment of tissue damage, containing a therapeutically effective dose of apyrase and one or more pharmaceutically acceptable carriers.

EFFECT: invention improves the efficiency of tissue damage treatment.

16 cl, 12 dwg, 35 tbl, 16 ex

Description

FIELD OF TECHNOLOGY

The present invention relates to the development and therapeutic use of solubilized polypeptide apyrases, pharmaceutical compositions and methods useful for the prevention and treatment of tissue damage.

BACKGROUND OF THE INVENTION

Apyrase (ATP-diphosphatase, adenosine diphosphatase, ADPase, or ATP-diphosphohydrolase) is a group of cytoplasmic membrane-associated enzymes that are active on both nucleotide di- and triphosphates (NDP and NTP) and hydrolyze NTP to produce nucleotide monophosphates (NMP) in two separate sequential steps that release phosphate, with NDPs acting as intermediates. Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this family of enzymes. They differ from ATPases, which specifically hydrolyze ATP, in that they hydrolyze both ATP and ADP.

The first known human apyrase, ectonucleoside triphosphate diphosphohydrolase-1 (gene: ENTPD1, protein: NTPDase 1), also known as cluster of differentiation 39 (CD39, UniProt P49961, or SEQ ID NO: 1), is a cell surface localized enzyme with catalytic center facing the extracellular space.

In the known human CD39 family, its representative CD39L3 is known as ectoapyrase (ecto-ATPDase) and is intermediate in biochemical activity between CD39 and CD39L1 (ecto-ATPase). In particular, human CD39L3 has been solubilized and purified for therapeutic purposes, for example, as disclosed in US7247300B1 (incorporated herein by reference) or incorporated herein under SEQ ID NO: 3.

BRIEF DESCRIPTION OF THE INVENTION

The present invention based, inter alia, on the unexpected finding that certain modifications to a solubilized human apyrase, such as human CD39, result in a surprisingly active protein that is both safe and easy to manufacture.

According to a first aspect of the present invention, there is provided a solubilized human apyrase containing at least two modifications selected from the list consisting of an N-terminal deletion, a C-terminal deletion and a central region modification.

In one embodiment, the solubilized human apyrase contains an N-terminal deletion, a C-terminal deletion, and a deletion type modification.

In one embodiment, the modification of the central region includes the deletion of one or more amino acids. In another embodiment, the modification of the central region includes a point mutation of one or more amino acids, such as a substitution type mutation. In yet another embodiment, the central region modification is a combination of a deletion of one or more amino acids and a point mutation, such as a substitution type mutation, of one or more amino acids.

An N-terminal deletion may be a 30 to 50 amino acid deletion at the N-terminus of the wild-type CD39 sequence according to SEQ ID NO: 1, such as 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 , 40, 41, 42, 43, 44, 45, 46, 47, 48, 49 or 50 amino acids. In a preferred embodiment, the N-terminal deletion is a 34, 37, 38 or 45 amino acid deletion.

The C-terminal deletion may be a deletion of 20 to 40 amino acids at the C-terminus of the wild-type CD39 sequence according to SEQ ID NO: 1, such as deletion 20, 21, 22, 23, 24, 25, 26, 27, 28, 29 , 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 or 40 amino acids. In a preferred embodiment, the C-terminal deletion is a 22, 29 or 37 amino acid deletion.

A deletion in the central region may be a deletion of 10 to 15 consecutive amino acids of the wild-type CD39 sequence according to SEQ ID NO: 1, such as a deletion of 10, 11, 12, 13, 14 or 15 amino acids. In a preferred embodiment, the deletion in the central region is a 12 amino acid deletion, such as amino acids 193 to 204, relative to the wild-type CD39 sequence according to SEQ ID NO: 1.

In one embodiment, the solubilized human apyrase contains one, two, three, four or five point mutations relative to the sequence of wild-type CD39 according to SEQ ID NO: 1 selected from the group consisting of K71E, N73Q, V95A, G102D, Y104S, T106S , R113M, L149M, V151A, E173D, T229A, L254M, K258R, W263R, E276D, N292Q, R304G, I319T, N327Q, A362N, F365S, N371Q, K405N, Y412F, L424Q, H436D, I437N, F439S, G441D, N457Q, P463S , and S469R.

In one embodiment, the solubilized human apyrase contains a sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 32, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 70, SEQ ID NO: 76, and SEQ ID NO: 78.

In one embodiment, the solubilized human apyrase contains a sequence selected from the group consisting of SEQ ID NO: 131, SEQ ID NO: 133, SEQ ID NO: 135, SEQ ID NO: 137, SEQ ID NO: 139, and SEQ ID NO: 141.

In one specific embodiment, the solubilized human apyrase contains a sequence selected from the group consisting of SEQ ID NO: 213, SEQ ID NO: 227, SEQ ID NO: 219, SEQ ID NO: 227, SEQ ID NO: 217, SEQ ID NO : 209, SEQ ID NO: 221, SEQ ID NO: 72, SEQ ID NO: 215, SEQ ID NO: 223, SEQ ID NO: 211, SEQ ID NO: 58 and SEQ ID NO: 229.

In one specific embodiment, the solubilized human apyrase consists of a sequence selected from the group consisting of SEQ ID NO: 213, SEQ ID NO: 227, SEQ ID NO: 219, SEQ ID NO: 227, SEQ ID NO: 217, SEQ ID NO: 209, SEQ ID NO: 221, SEQ ID NO: 72, SEQ ID NO: 215, SEQ ID NO: 223, SEQ ID NO: 211, SEQ ID NO: 58 and SEQ ID NO: 229.

In a preferred embodiment, the solubilized human apyrase contains a sequence selected from the group consisting of SEQ ID NO: 58, SEQ ID NO: 72, and SEQ ID NO: 229.

In one embodiment, the solubilized human apyrase comprises SEQ ID NO: 58. In one embodiment, the solubilized human apyrase comprises SEQ ID NO: 72. In one embodiment, the solubilized human apyrase comprises SEQ ID NO: 229.

In a preferred embodiment, the solubilized human apyrase consists of a sequence selected from the group consisting of SEQ ID NO: 58, SEQ ID NO: 72 and SEQ ID NO: 229.

In one embodiment, the solubilized human apyrase consists of SEQ ID NO: 58. In one embodiment, the solubilized human apyrase consists of SEQ ID NO: 72. In one embodiment, the solubilized human apyrase consists of SEQ ID NO: 229.

According to a second aspect of the present invention, the present invention relates to a pharmaceutical composition comprising a therapeutically effective dose of apyrase according to the first aspect of the present invention and one or more pharmaceutically acceptable carriers provided.

In one embodiment, the pharmaceutical composition further comprises one or more additional active ingredients.

According to a third aspect of the present invention, an isolated apyrase according to the first aspect is provided for use as a drug.

According to a fourth aspect of the present invention, an isolated apyrase according to the first aspect is provided for use in the treatment of tissue injury.

Tissue damage can be acute brain injury (stroke); acute multiple organ failure; delayed graft function after transplantation of a kidney or other solid organs; burn; radiation damage; acute injury due to trauma and/or hypoxia, such as acute respiratory distress syndrome (ARDS) or lung injury; acute kidney injury, such as acute kidney injury due to chest surgery (eg, aortic valve replacement, coronary artery bypass grafting), or sepsis, or rhabdomyolysis, or toxic effects of antibiotics or other drugs; acute myocardial injury.

In another embodiment, the fourth aspect of the present invention provides an isolated apyrase according to the first aspect of the present invention for use in the treatment of acute kidney injury associated with cardiac surgery.

In another embodiment, the fourth aspect of the present invention provides an isolated apyrase according to the first aspect of the present invention for use in the treatment of delayed graft function (DGF), acute respiratory distress syndrome (ARDS), acute myocardial infarction (AMI), traumatic brain injury (TBI )/acute ischemic stroke (AIS), ischemia-reperfusion injury (IRI), or combinations thereof, often referred to as forms of multiple organ failure (MOF).

In one embodiment, the solubilized human apyrase used to treat acute kidney injury associated with cardiac surgery contains the amino acid sequence of SEQ ID NO: 58.

In one embodiment, the solubilized human apyrase used to treat acute kidney injury associated with cardiac surgery contains the amino acid sequence of SEQ ID NO: 72. In one embodiment, the solubilized human apyrase used to treat acute kidney injury associated with cardiac surgery. operation on the heart, contains the amino acid sequence under SEQ ID NO: 229.

In a further preferred embodiment, the present invention relates to the use of an isolated apyrase according to the first aspect of the present invention for the treatment of acute kidney injury associated with sepsis.

In one embodiment of the fourth aspect, the solubilized human apyrase for use in the treatment of sepsis-associated acute kidney injury comprises the amino acid sequence of SEQ ID NO: 58.

In one embodiment of the fourth aspect, the solubilized human apyrase for use in the treatment of sepsis-associated acute kidney injury comprises the amino acid sequence of SEQ ID NO: 72.

In one embodiment of the fourth aspect, the solubilized human apyrase for use in the treatment of sepsis-associated acute kidney injury comprises the amino acid sequence of SEQ ID NO: 229.

According to a fifth aspect of the present invention, there is provided a method for treating tissue damage in a human subject, comprising administering to said subject a therapeutically effective dose of a solubilized human apyrase according to the first aspect. One embodiment of the fifth aspect of the present invention relates to a method of treating acute kidney injury associated with cardiac surgery, comprising administering to a subject in need of such treatment, a therapeutically effective dose of isolated apyrase according to the first aspect of the present invention.

Another embodiment of the fifth aspect of the present invention relates to a method for treating delayed graft function (DGF), acute respiratory distress syndrome (ARDS), acute myocardial infarction (AMI), traumatic brain injury (TBI)/acute ischemic stroke (AIS), ischemic -reperfusion injury (IRI) or combinations thereof, often referred to as forms of multiple organ failure (MOF), comprising administering to a subject in need of such treatment, a therapeutically effective dose of isolated apyrase according to the first aspect of the present invention.

In one embodiment of the fifth aspect, the solubilized human apyrase used in the method of treating acute kidney injury associated with cardiac surgery comprises the amino acid sequence of SEQ ID NO: 58, SEQ ID NO: 72, or SEQ ID NO: 229.

One embodiment of the fifth aspect of the present invention relates to a method of treating acute kidney injury associated with sepsis, comprising administering to a subject in need of such treatment, a therapeutically effective dose of isolated apyrase according to the first aspect of the present invention.

In one embodiment of the fifth aspect, the solubilized human apyrase used in the method of treating sepsis-associated acute kidney injury comprises the amino acid sequence of SEQ ID NO: 58, SEQ ID NO: 72, or SEQ ID NO: 229. The tissue injury may be an acute brain damage (stroke); acute multiple organ failure; delayed graft function after transplantation of a kidney or other solid organs; burn; radiation damage; acute injury due to trauma and/or hypoxia, such as acute respiratory distress syndrome (ARDS) or lung injury; acute kidney injury, such as acute kidney injury due to chest surgery (eg, aortic valve replacement, coronary artery bypass grafting), or sepsis, or rhabdomyolysis, or toxic effects of antibiotics or other drugs; acute myocardial injury.

According to a sixth aspect of the present invention, there is provided an isolated nucleic acid molecule encoding any apyrase according to the first aspect.

According to a seventh aspect of the present invention, there is provided a cloning or expression vector comprising one or more nucleic acid sequences according to the sixth aspect, wherein the vector is suitable for recombinant production of the isolated apyrase according to the first aspect.

According to an eighth aspect of the present invention, there is provided a host cell comprising one or more cloning or expression vectors according to the seventh aspect.

According to a ninth aspect of the present invention, there is provided a method for producing apyrase according to the first aspect, comprising culturing a host cell according to the eighth aspect, purifying and recovering said apyrase.

BRIEF DESCRIPTION OF GRAPHICS

The figure 1 shows the alignment of sequences;

Figure 2A shows the expression level of human CD39 in a supernatant containing it, determined by Western blotting using an anti-APP antibody according to an embodiment;

Figure 2B shows the level of expression of human CD39 variants with a cysteine bridge deletion in the supernatant containing them, determined by Western blotting using an anti-APP antibody according to an embodiment;

Figure 3 is a graph showing the results of the ATPase AP analysis for CD39 variants;

Figure 4 is a graph showing solid phase ATP cleavage on HEK293 cells transformed with human CD39 variants according to the embodiment;

Figure 5 is a diagram of a vector according to an embodiment;

figure 6 shows a model of enzymatic activity based on a stationary approximation;

Figure 7 provides an overview of kinetic data and model fit for a protein according to an embodiment;

Figure 8 provides an overview of kinetic data and model fit for a protein according to an embodiment;

Figure 9 provides an overview of kinetic data and model fit for a protein according to an embodiment;

Figure 10 is a schematic representation of the experimental conditions;

Figure 11 is a graph showing AMP levels for proteins according to embodiments; And

Figure 12 is a graph showing in vivo results for proteins according to the embodiments.

DETAILED DESCRIPTION OF THE INVENTION

The present invention based, among other things, on the unexpected finding that certain modifications to solubilized CD39 result in a surprisingly active protein that is safe and easy to manufacture.

As will be shown in the specific examples below, a preferred embodiment is a solubilized human apyrase containing at least two modifications selected from a list consisting of an N-terminal deletion, a C-terminal deletion, and a deletion in the central region, such as solubilized human apyrase, containing a sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 32, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 70, SEQ ID NO: 76 , and SEQ ID NO: 78.

Several different sequence modification strategies have been tried by the present inventors in order to obtain a solubilized human apyrase with both retained activity and expressibility, while at the same time not introducing too many modifications due to the risk of increasing immunogenicity and thus increased security risk. Unexpectedly, one of the sequence modifications that was found to simultaneously increase both the efficiency and the ability to express in human apyrase, and at the same time did not add too high a risk of immunogenicity, was a deletion in the central region - the so-called delta modification. MIL (∆MIL).

To increase the expression of solubilized human apyrase, N-terminal expression tags were tested in accordance with embodiments of the present invention. Various N-terminal expression tags are known in the art, however surprisingly not all of the tags were functional. The inventors of the present invention found that only some of the labels functioned, which was unpredictable.

These N-terminal tags were SEQ ID NO: 131, SEQ ID NO: 133, SEQ ID NO: 135, SEQ ID NO: 137, SEQ ID NO: 139, or SEQ ID NO: 141. As shown herein, particularly preferred the labels are SEQ ID NO: 133, SEQ ID NO: 135, or SEQ ID NO: 137.

Specific details are set forth in Examples 9-13 below. However, to illustrate the unpredictable nature of these examples, Table 1 provides a comparative summary.

Table 1 Summary of Preferred Embodiments Design Modifications Activity vs Baseline EP28 Titer (g/l) N-terminal amino acid number from SEQ ID NO: 131 Number of point mutations In vitro in vivo EP1xEP17 6 2 1.5x 0.6 EP17xEP19 6 2 1.5x 0.26 EP1xEP17xEP19 6 3 1.5x 0.46 EP17xEP19 3 2 1.5x 0.40 EP1xEP17xEP19 3 3 1.5x 0.58 EP1 3 1 1x 0.29 EP1xEP14 3 2 4x 0.50 EP28 16 0 1x 1x 0.08 EP1xEP17_K405N 15 3 1.5x 1x 1.4 EP1xEP14 6 2 4x 0.3 EP1xEP17 3 2 1.5x 0.68 EP28 3 0 1x 0.10 EP14 3 1 4x 4x 0.27

1. Definitions

To facilitate the practical implementation of the present invention by a person skilled in the art throughout the present description, the following terms are used.

The terms "CD39" and "hCD39" are used interchangeably throughout the present invention and, unless otherwise indicated, refer to the human cluster of differentiation 39 (CD39) according to UniProt P49961 or SEQ ID NO: 1.

The term "apirase" refers to human apyrase unless otherwise indicated. The term "solubilized apyrase" as used herein means that the apyrase, which, being a wild-type protein, exists in a form bound to the cell membrane, has been modified so that it is no longer bound to the cell membrane, but exists in a soluble form. state, i.e. no longer anchored to the cell membrane.

The abbreviation "MIL" refers to the membrane-interacting loop, which is the central portion of the wild-type (human) CD39 protein interacting with the cell membrane, in addition to the N-terminal and C-terminal portions, which are physically anchored to the cell membrane. The term "delta-MIL" or "ΔMIL" refers to a deletion of the MIL sequence in wild-type (human) CD39.

The term "about" in relation to the numerical value of x means, for example, +/- 10%. When used before a numerical range or list of numbers, the term "about" applies to each number in the series, for example, the phrase "about 1-5" should be interpreted as "from about 1 to about 5", or, for example, the phrase "about 1, 2, 3, 4" should be interpreted as "about 1, about 2, about 3, about 4, etc."

The word "substantially" does not exclude "completely", for example, a composition that is "substantially free" of Y may be completely free of Y. If necessary, the word "substantially" may be omitted from the definition of the present invention.

The term "comprising" encompasses "comprising" as well as "comprising", for example, a composition "comprising" X may consist solely of X, or may include something additional, such as X+Y.

The term "identity" in relation to a native polypeptide and its functional derivative is defined herein as the percentage of amino acid residues in a candidate sequence that are identical to those of the corresponding native polypeptide after sequence alignment and, if necessary, gapping to achieve the maximum percent identity, and without taking into account any conservative substitutions as part of the sequence identity. Neither N- or C-terminal extensions nor insertions should be considered as reducing identity. Methods and computer programs for alignment are well known. Percent identity can be determined using standard alignment algorithms, such as the Basic Local Alignment Finder (BLAST) described by Altshul et al. ((1990) J. Mol. Biol., 215: 403-410); algorithm of Needleman et al. ((1970) J. Mol. Biol., 48: 444-453) or the algorithm of Meyers et al. ((1988) Comput. Appl. Biosci., 4: 11-17). The parameter set can be a Blosum 62 weight matrix with a gap penalty of 12, a gap extension penalty of 4, and a frameshift gap penalty of 5. The percent identity between two amino acid or nucleotide sequences can also be determined using the algorithm of E. Meyers and W. Miller ((1989) CABIOS, 4:11-17), which was included in the ALIGN program (version 2.0), using the PAM120 residue substitution weight table, a gap extension penalty of 12, and a gap insertion penalty of 4.

The term "amino acid(s)" refers, for example, to all naturally occurring L-α-amino acids and includes D-amino acids. The phrase "variant amino acid sequence" refers to molecules with some differences in their amino acid sequences compared to the sequences according to the present invention. Variants of the amino acid sequence of the protein according to the present invention, for example, with the specified sequence, still have apyrase activity. Amino acid sequence variants include substitution variants (variants in which at least one amino acid residue has been removed and another amino acid inserted in its place at the same position in the polypeptide of the present invention), insertion variants (variants with one or more amino acids inserted in close proximity to an amino acid at a specific position in a polypeptide of the present invention) and deletion variants (variants in which one or more amino acids are deleted in a polypeptide of the present invention).

The term "treatment" or "treat" is defined herein as the use or administration to a subject of an apyrase of the present invention, or the use or administration to a subject, or to an isolated tissue or cell line derived from a subject, of a pharmaceutical composition containing said apyrase, wherein the subject has a lesion. tissue, a symptom associated with tissue damage, where the goal is to alleviate, reduce the intensity or improve the course of tissue damage or any associated symptoms of tissue damage, among other things, by reducing the levels of extracellular ATP.

The term "treatment" is also intended to refer to the use or administration to a subject of a pharmaceutical composition containing an apyrase, or the use or administration to an isolated tissue or cell line derived from a subject of a pharmaceutical composition containing an apyrase of the present invention, where the subject has tissue damage or a symptom associated with tissue damage, where the goal is to reduce, reduce the intensity or improve the course of tissue damage or any associated symptoms of tissue damage.

The term "prevent" or "prevention" refers to prophylactic or preventive treatment; it refers to delaying the onset or preventing the onset of a disease, disorder and/or symptoms associated therewith.

As used herein, a subject "needs" treatment if such treatment would result in such a subject benefiting from a biological, medical, or quality of life point of view.

The term "pharmaceutically acceptable" means a non-toxic material that does not interfere with the effectiveness of the biological activity of the active ingredient(s).

As used herein, "administering" or "administering" a compound in question means providing a compound of the present invention and its prodrugs to a subject in need of treatment. Administration "in combination with" one or more additional therapeutic agents includes simultaneous (parallel) and sequential administration in any order and by any route of administration.

As used herein, the term "therapeutically effective dose" refers to a dose (amount) of apyrase that is effective when administered in single or multiple doses to a patient (such as a human) to treat, prevent, prevent onset, cure, delay, reduce severity, reduce the intensity of at least one symptom of the disorder or recurrent disorder or prolongation of the patient's survival beyond that expected in the absence of such treatment. When applied to an individual active ingredient (eg apyrase) administered separately, the term refers to that ingredient only. When applied to a combination, the term refers to the combined doses or amounts of active ingredients that result in a therapeutic effect, whether administered in combination, sequentially or simultaneously.

The phrase "dosing regimen" means a regimen used to treat a disease, such as a dosing protocol used during the treatment of tissue injury.

The phrase "injection means" is used to refer to any available device for the systemic administration of a drug to a patient, including, without limitation, a pre-filled syringe, a vial and a syringe, a syringe pen, an auto-injector, an intravenous (i.v.) dropper and bag, a pump, a patch pump, etc. With these devices, the patient may self-administer the drug (i.e. self-administer the drug), or the drug may be administered by a doctor.

2. Example 1: Non-membrane bound CD39

Wild-type human CD39 apyrase (hCD39, UniProt P49961 or SEQ ID NO: 1) is naturally anchored to the cell membrane by a transmembrane domain at the N-terminus (presumably represented by a.k. 17-37), a putative central loop interacting with membrane (MIL, presumably represented by a.k. 193-204), and a C-terminal transmembrane domain (presumably represented by a.k. 479-499). To allow expression of a soluble CD39 variant using a mammalian host cell, several elements of the CD39 sequence were modified to produce a non-membrane-bound or solubilized protein. The natural leader sequence and the N-terminal transmembrane region were replaced with a secretory leader sequence and a purification tag (SEQ ID NO: 133). CD39 extracellular domain boundaries were altered to optimize expression, purification and activity parameters (amino acids #38-476 of SEQ ID NO: 1, amino acids #39-469 of SEQ ID NO: 1, amino acids 46-461 of SEQ ID NO: 1 and amino acids 46-476 of SEQ ID NO: 1, respectively). The effect of cysteine residues and disulfide bridges on aggregation propensity and enzymatic activity was systematically assessed by replacing cysteine residues with alanine or by shortening the loop formed by the disulfide bridge (SEQ ID NOS: 107, 109, 111, 113 and 115). A fragment of hydrophobic amino acids has been described in a study on the structure of rat CD39 (Zebisch et al, J. Mol. Biol. (2012), 415, 288-306, wild-type rat CD39, Uniprot P97687, presented under SEQ ID NO: 2) , and there is reason to believe that this loop can interact with the cell membrane (MIL). We applied these findings to the human CD39 sequence by sequence alignment and generated loop deletion variants of CD39 (CD39ΔMIL or EP28 represented under SEQ ID NO: 4). The influence of the deletion (or delta/Δ) of MIL on the expression level of functional CD39 and thermal stability was assessed.

As can be seen in Figure 1, which shows the sequence alignment of SEQ ID NO: 1 and SEQ ID NO: 4, N-terminal amino acids 1-27, C-terminal amino acids 477-510 and amino acids 193-204 of the central membrane interacting loop (MIL) were deleted in wtCD39 (SEQ ID NO: 1) to form CD39ΔMIL (SEQ ID NO: 4).

The effect of various sequence modifications on thermal stability was studied. In addition, the effect of various sequence modifications on the expression yield and monomer content on CHO cells was studied.

(1) Ways

(a) Preparation of expression plasmids

DNA sequences encoding hCD39 with various border variants and a membrane interacting loop (MIL) deletion were ordered from GeneArt (Life Technologies Inc., Regensburg, Germany) with codon optimization for Homo sapiens. The hCD39 variant coding sequences were subcloned using standard molecular biology techniques from GeneArt derived vectors or in-house derived variants thereof into an expression vector suitable for secretion in mammalian cells. The modified oligonucleotides were targeted for cysteine to alanine mutations present in cysteine bridge deletion variants, and after a subsequent assembly PCR step, the resulting fragments were subcloned into the same expression vector mentioned earlier. Expression vector elements include a promoter (cytomegalovirus (CMV) enhancer-promoter tandem), a signal sequence to facilitate secretion, a polyadenylation signal and a transcription terminator (bovine growth hormone (BGH) gene), an element enabling episomal replication and replication in prokaryotes ( for example, the origin of replication SV40 and ColE1 or others known in the art), and elements to enable selection (ampicillin resistance gene and zeocin resistance marker). A list of truncated, solubilized human CD39 variants is presented in Table 2 , where amino acid modifications are numbered relative to SEQ ID NO: 1.

Table 2. Truncated, solubilized variants of human CD39 Reference name Amino acid sequence ID Modification(s) CD39(aa39-469) SEQ ID NO: 99 N- and C-terminal truncations CD39(aa46-476) SEQ ID NO: 101 N- and C-terminal truncations CD39(aa46-461) SEQ ID NO: 103 N- and C-terminal truncations CD39(aa46-461)_dMIL(193-204) SEQ ID NO: 105 N- and C-terminal truncations and deletion in the central region CD39(aa46-461)_delta-cys1 SEQ ID NO: 107 N- and C-terminal truncations and cysteine deletion CD39(aa46-461)_delta-cys2 SEQ ID NO: 109 N- and C-terminal truncations and cysteine deletion CD39(aa46-461)_delta-cys3 SEQ ID NO: 111 N- and C-terminal truncations and cysteine deletion CD39(aa46-461)_delta-cys4 SEQ ID NO: 113 N- and C-terminal truncations and cysteine deletion CD39(aa46-461)_delta-cys5 SEQ ID NO: 115 N- and C-terminal truncations and cysteine deletion CD39(aa46-461)_dMIL(193-204)_delta-cys1 SEQ ID NO: 117 N- and C-terminal truncations, deletion in the central region and deletion of cysteine CD39(aa46-461)_dMIL(193-204)_delta-cys2 SEQ ID NO: 119 N- and C-terminal truncations, deletion in the central region and deletion of cysteine CD39(aa46-461)_dMIL(193-204)_delta-cys3 SEQ ID NO: 121 N- and C-terminal truncations, deletion in the central region and deletion of cysteine CD39(aa46-461)_dMIL(193-204)_delta-cys4 SEQ ID NO: 123 N- and C-terminal truncations, deletion in the central region and deletion of cysteine CD39(aa46-461)_dMIL(193-204)_delta-cys5 SEQ ID NO: 125 N- and C-terminal truncations, deletion in the central region and deletion of cysteine CD39(aa38-476)_delta-337-344 SEQ ID NO: 127 N- and C-terminal truncations and cysteine deletion CD39(aa38-476)_C338A_C343A SEQ ID NO: 129 Cysteine N- and C-terminal truncations and point mutations

(b) Microscale expression of hCD39 variants

Cells 293-6E (disclosed in WO2006096989A2, incorporated herein by reference) were selected for microscale experiment as one of the preferred host cell lines for transient expression of proteins in the absence of blood serum. Transfection was performed using FuGene HD (Roche Applied Science, cat. no. 04709705001) as a transfection reagent. 293-6E cells were cultured as a suspension culture using V3 serum-free culture medium (BioConcept cat. no. V3-K) for transfection and cell expansion. Cells were grown in Corning shake flasks (Corning, Tewkesbury, MA) on an orbital shaker (100-120 rpm) in a humidified 5% CO ₂ incubator (in flasks containing inoculum). For transfection, cells in seed cultures should be maintained in an exponential growth phase (at cell densities of 5x10 ⁵ to 3x10 ⁶ /ml) and should demonstrate >90% viability. Cell densities outside this range either result in a lag phase after dilution or a decrease in transfection efficiency.

For microscale (0.5 ml) transfections, an aliquot of cells was taken from the seed cultures and adjusted to 0.5×10 ⁶ cells/ml with serum-free V3 culture medium. A DNA solution (referred to as solution 1) was prepared by diluting 0.5 µg of hCD39 expression plasmids in 14 µl of V3 serum-free culture medium, then 2.3 µl of FuGene HD solution was also diluted in 14 µl of V3 serum-free culture medium (solution 2). Both solutions were incubated for 5-10 min. at room temperature (RT). Then solution 2 was added to solution 1 with gentle stirring and incubated for another 5-15 minutes at room temperature. The transfection mixture was then added to 0.5 ml of cells at a density of 0.5 x 10 ⁶ cells/ml seeded in a 48-well tissue culture plate (Corning, Tewkesbury, MA) and the plate was placed on an orbital shaker (300 vol. /min.) in a humidified incubator at 5% CO ₂ . The culture was harvested 3 days after transfection by centrifugation at 4000 rpm. for 10 minutes at 4°C (Heraeus Multifuge 3 SR, Thermo Scientific, Rockford, IL). The recovered cell culture supernatant was stored at 4° C. until further processing.

(c) Western blot analysis of the supernatant obtained from microscale expression

Western blot analysis of the microscale expression supernatant was performed to verify the expression and correct formation of recombinant hCD39 variants. 8 μl of the supernatant was diluted in E-PAGE™ loading buffer (4x, Invitrogen, # EPBNF-01) and loaded onto an 8% E-Page 48 gel (Invitrogen, # EP04808) under non-reducing conditions. A gel run was performed with a Mother E-Base (Invitrogen) for 23 minutes, and proteins were transferred to a nitrocellulose membrane (Invitrogen IB301001) using an iBlot system (Invitrogen) according to the manufacturer's instructions (7-minute run). After washing 3 times in TBS/0.05 Tween20 (TBST), the membrane was incubated for 1 hour in the presence of 5% milk/TBST with gentle agitation, followed by incubation for 1 hour in the presence of 4 μg/ml of anti-mouse APP antibody solution ( an antibody raised against a peptide fragment of the amyloid precursor protein (APP) used for labeling proteins, obtained in-house by Novartis) diluted in 2% milk/TBST. After an additional 3 washing steps, the membrane was incubated in the presence of a 1:1000 diluted anti-mouse IgG alkaline phosphatase-conjugated antibody (Sigma-Aldrich, A5153-1ML) diluted in 2% milk/TBST and washed again 3 times in TBST followed by rinses in TBS. The signal was developed for 1-5 minutes with SIGMAFAST™ BCIP®/NBT (Sigma-Aldrich, no. B5655-25TAB) according to the manufacturer's instructions, and the signal was terminated by rinsing the membrane with water.

(d) Solid phase analysis of AxPase

ATPase, ADPase, and AMPase activity patterns were determined using the PiColorLock Gold Phosphate Detection System (Innova Biosciences, cat. no. 303-0030) in plate-immobilized hCD39 variants from microscale expression supernatant (AxPase solid-phase analysis). This method proved to be less sensitive than the solution assay (AxPase liquid phase assay) recommended by the manufacturer, but potentially had the advantage of reducing AxPase activity mediated by host cell enzymes potentially present in the supernatant obtained from microscale expression. 20 µl of anti-mouse APP antibody from a 10 µg/ml solution of an antibody (an antibody raised against a peptide fragment of amyloid precursor protein (APP) used to label proteins, which is obtained in Novartis' own laboratory) diluted in PBS was added to each well 384 -well transparent tablet MaxiSorp (Nunc) and incubated overnight at 4°C. After three washes with TBST, the wells were blocked for 1 hour with 100 μl of 5% milk/TBST at room temperature with gentle agitation. After three additional washing steps, 20 µl of microscale expression supernatant serially diluted in 2% milk/TBST was added to the wells in triplicate and incubated for 2 hours at room temperature with gentle agitation. The wells were then washed again four times with 100 μl TBST and twice with 80 μl 50 mM Tris-Cl/5 mM MgCl ₂ , pH 7.5. 30 μl of an 80 μM adenosine phosphate solution diluted in 50 mM Tris-Cl/5 mM MgCl ₂ , pH 7.5 (ATP: SIGMA A2383, ADP: SIGMA A2754) was added to each of three replicates and incubated for 24 hours at 37° C. The signal was developed with 7.5 µl of the Gold reagent mixture prepared according to the manufacturer's instructions for 10 minutes and the reaction was stopped with 3 µl of stabilizer. Absorbances were read at 620 nm using a TECAN GeniOS Pro instrument.

(2) Results

(a) Effect of borders, membrane interacting loop (MIL) deletion, and cysteine bridge deletion on hCD39 expression level

In order to assess the level of expression of various hCD39 variants, the corresponding expression plasmids were introduced by transfection in duplicate into 0.5 ml of 293-6E cells, and a Western blot (with detector Abs to APP) was performed on the supernatant obtained 3 days after transfection. The results are presented in figure 2A and figure 2B.

The results indicated a higher level of expression of hCD39 starting with aa38 compared to aa46. The borders of the N-terminal region, as well as the deletion of MIL, apparently did not significantly affect the level of expression. Also observed a higher expression level of hCD39 with a deletion of the first or fourth cysteine bridge in the case of hCD39 (aa46-461). A higher level of expression upon deletion of the first cysteine bridge was also confirmed using the backbone of hCD39 (aa46-461) ΔMIL.

(b) Effect of borders, membrane interacting loop (MIL) deletion, and cysteine bridge deletion on hCD39 activity

CD39 enzymatic activity was measured by AxPase solid phase analysis using the supernatant samples described above. The results are presented in figure 3 and figure 4, as well as in table 3 .

Table 3. ATP Solid Phase Analysis Using CD39 Variants Sample Subsequence Average signal Breeding 1/2 Breeding 1/6 Breeding 1/18 Breeding 1/54 Figure 3 hCD39 (aa46-461)_delta-Cys1 SEQ ID NO: 107 0.12755 0.12905 0.13155 0.13545 hCD39 (aa46-461)_delta-Cys2 SEQ ID NO: 109 0.1287 0.13615 0.12915 0.1375 hCD39 (aa46-461)_delta-Cys3 SEQ ID NO: 111 0.12265 0.1336 0.13485 0.1365 hCD39 (aa46-461)_delta-Cys4 SEQ ID NO: 113 0.14 0.1302 0.13535 0.1322 hCD39 (aa46-461)_delta-Cys5 SEQ ID NO: 115 0.1226 0.13865 0.13375 0.13225 hCD39 (aa46-461)_delta-MIL_delta-Cys1 SEQ ID NO: 117 0.17695 0.16 0.15755 0.1551 hCD39 (aa46-461)_delta-MIL_delta-Cys2 SEQ ID NO: 119 0.1318 0.1419 0.13065 0.1299 hCD39 (aa46-461)_delta-MIL_delta-Cys3 SEQ ID NO: 121 0.13505 0.1376 0.1347 0.13775 hCD39 (aa46-461)_delta-MIL_delta-Cys4 SEQ ID NO: 123 0.21195 0.18745 0.16915 0.14975 hCD39 (aa46-461)_delta-MIL_delta-Cys5 SEQ ID NO: 125 0.1343 0.1486 0.13135 0.10465 hCD39 (aa46-461) SEQ ID NO: 103 0.30345 0.2433 0.1879 0.1851 hCD39 (aa46-461)_delta-MIL SEQ ID NO: 105 0.5037 0.3779 0.32345 0.2567 hCD39 (aa38-476) Sequence not shown 0.30745 0.23855 0.18315 0.17295 hCD39 (aa46-476) SEQ ID NO: 101 0.34815 0.254 0.1975 0.1817 Without transfection 0.1459 0.14155 0.13855 0.13675 Figure 4 hCD39 (aa38-476) Sequence not shown 0.45775 0.4007 0.1997 0.14215 hCD39 (aa46-461)_delta-MIL SEQ ID NO: 105 0.8983 0.9294 0.6561 0.35405 hCD39 (aa46-476) SEQ ID NO: 101 0.5756 0.4855 0.27525 0.153 hCD39 (aa46-461) SEQ ID NO: 103 0.562 0.52455 0.28625 0.15175 hCD39 (aa38-476)_delta-MIL (EP28) SEQ ID NO: 4 1.0224 0.9696 0.6263 0.4354 Without transfection 0.1483 0.1494 0.158 0.1502

The deletion of MIL appeared to increase the proportion of functionally expressed recombinant CD39 proteins. The different boundary variants did not show any significant effect on active hCD39 activity. The results indicated a significantly reduced or completely eliminated ATPase activity for all variants with a deletion of the cysteine bridge. Similar results were obtained during the solid phase analysis of ADPase. Thus, surprisingly, the sequence modification that increased both the efficiency and the ability to express in CD39 was the delta-MIL (ΔMIL) modification.

3. Example 2: expression marks

In order to improve the expression properties of candidates, various expression labels were tested.

Various expression tags based on the N-terminal portion of IL-2 (SEQ ID NO: 131) shown in Table 4 were tested. The aa1-16 expression tag according to SEQ ID NO: 131 was synthesized at GeneArt.

Table 4 Overview of IL-2 expression tag variants Reference name Amino acid sequence ID Forward primer sequence ID Reverse primer sequence ID Expression tag aa1-16 SEQ ID NO: 131 n. O. n. O. Expression tag aa1-15 SEQ ID NO: 133 SEQ ID NO: 157 SEQ ID NO: 158 Expression tag aa1-6 SEQ ID NO: 135 SEQ ID NO: 159 SEQ ID NO: 158 Expression tag aa1-3 SEQ ID NO: 137 SEQ ID NO: 161 SEQ ID NO: 158 Expression tag aa1-9 SEQ ID NO: 139 SEQ ID NO: 162 SEQ ID NO: 158 Expression tag aa1-12 SEQ ID NO: 141 SEQ ID NO: 163 SEQ ID NO: 158 Expression tag aa4-12 SEQ ID NO: 143 SEQ ID NO: 164 SEQ ID NO: 158

All expression tags were tested against CD39ΔMIL shown under SEQ ID NO: 4. All constructs contain an APP tag and a His tag.

The pRS5a vector shown in Figure 5 was used for expression. The primer pairs corresponded to those presented in Table 4 .

The annealing temperature was 64°C in all cases.

A PCR solution was prepared by mixing 1 µl template DNA stock solution, 25 µl Kapa HiFi HotStart polymerase (from Kapa Biosystems/KK2602). 1.5 µl forward primer, 1.5 µl reverse primer were used and the final volume was adjusted to 50 µl with H ₂ O.

The PCR reaction was carried out in accordance with the order given in Table 5 .

Table 5. PCR procedure Temperature (C°) Time (min.) Cycles Denaturation 94 5 1 Denaturation 94 0.5 35 Annealing 64 1.5 Polymerization 72 0.5 Final polymerization 72 5

After completion of the PCR reaction, DNA extraction was performed using the Wizard® SV Gel and PCR Clean-Up kit, Promega, #9282, eluting with 30 µl in 1 column according to the manufacturer's instructions.

Inserts and vector were excised using enzyme supplied by New England Biolabs (NEB), NruI-HF (NEB # R3192) and NotI-HF (NEB # R3189) in CutSmart(R) buffer. The reaction time was 3 hours at 37°C.

Ligation was performed overnight in the presence of the dephosphorylated vector using Roche Rapid Dephosphorylation and DNA Ligation Kit No. 04898117001 according to the manufacturer's actual protocol.

The following day, individual colonies were selected for DNA extraction in miniquantities and sequence analysis using forward primer P270 (SEQ ID NO: 165) and reverse primer P271 (SEQ ID NO: 166).

In addition, several protein sequences known in the art to increase expression were tested according to Table 6 .

Table 6. Tags known from the prior art Reference name Sequence ID Ubiquitin SEQ ID NO: 167 C-kappa SEQ ID NO: 168 Domain I HSA SEQ ID NO: 169 Domain II HSA SEQ ID NO: 170

The resulting test combinations are shown in Table 7.

Table 7. Constructs tested Plasmid name The resulting amino acid sequence pRS5a_IL2-leader-APP6-Flag-hCD39(aa38-476)_delta-MIL(aa193-204)_8M-optimized SEQ ID NO: 145 pRS5a_IL2-leader-hs-ubiquitin-hCD39(aa38-476)_delta-MIL(aa193-204)_APP_His SEQ ID NO: 149 pRS5a_IL2-leader-hs-C-kappa-hCD39(aa38-476)_delta-MIL(aa193-204)_APP_His SEQ ID NO: 147 pRS5a_IL2-leader-HSA-domain I-hCD39(aa38-476)_delta-MIL(aa193-204)_APP_His SEQ ID NO: 151 pRS5a_IL2-leader-HSA-domain II-hCD39(aa38-476)_delta-MIL(aa193-204)_APP_His SEQ ID NO: 153

None of the labels known from the prior art and presented in table 6, did not provide protein expression (data not shown). This was unexpected since it is known in the prior art that such sequences should increase expression.

4. Example 3: additional mutations

In order to improve the characteristics of soluble CD39 and make it suitable for pharmaceutical development, further modifications were made to CD39ΔMIL EP28 as shown under SEQ ID NO: 4. Various mutations and variants with mutations are shown in Table 8 and numbered according to the amino acid positions in CD39. wild type shown under SEQ ID NO: 1.

Table 8. Point mutations abbreviation Number of mutations Mutation position 1 Mutation position 2 Mutation position 3 Mutation position 4 Mutation position 5 Amino acid sequence ID EP1 1 113: R->M SEQ ID NO: 6 EP2 2 113: R->M 149: L->M SEQ ID NO: 8 EP3 3 113: R->M 304: R->G 469: S->R SEQ ID NO: 10 EP4 3 95: V->A 113: R->M 469: S->R SEQ ID NO: 12 EP5 2 149: L->M 441: G->D SEQ ID NO: 14 EP6 3 104: Y->S 149: L->M 263: W->R SEQ ID NO: 16 EP7 4 71: K->E 106: T->S 151: V->A 319: I->T SEQ ID NO: 18 EP8 1 151: V->A SEQ ID NO: 20 EP9 1 263: W->R SEQ ID NO: 22 EP10 1 319: I->T SEQ ID NO: 24 EP11 2 113: R->M 319: I->T SEQ ID NO: 26 EP12 2 276: E->D 319: I->T SEQ ID NO: 28 EP13 2 365: F->S 424: L->P SEQ ID NO: 30 EP14 1 365: F->S SEQ ID NO: 32 EP15 4 292: N->K 365: F->S 424: L->P 463: P->S SEQ ID NO: 34 EP17.1 1 412: Y->F SEQ ID NO: 38 EP17 2 405: K->N 412: Y->F SEQID No. 36 EP18 2 102: G->D 424: L->Q SEQID No. 40 EP19 2 424: L->Q 436: H->D SEQID No. 42 EP20 2 276: E->G 439: F->S SEQID No. 44 EP21 2 113: R->M 469: S->R SEQID No. 46 EP22 2 276: E->G 469: S->G SEQID No. 48 EP23 4 254: L->M 263: W->R 439: F->S 469: S->R SEQID No. 50 EP24 3 113: R->K 424: L->Q 437: I->N SEQID No. 52 EP28_8M 8 173: E->D 258: K->R 362: A->N 365: F->Y 404-411:
VKEKYLSE->
-QERWLRD SEQID No. 145

Two mutations in the active site result in higher activity (365 and 412).

5. Example 4: removal of the glycosylation site

Using the EP14 variant above, the effect of glycosylation sites was tested by introducing point mutations according to Table 9, numbered according to the amino acid positions in wild-type CD39 shown under SEQ ID NO: 1.

Table 9. Mutations in glycosylation sites Mutation position Glycosylation site primer N73Q NDT P928/P929 T229A NQT P930/P931 N292Q NVS P932/P933 N327Q NTS P934/P935 N371Q NLT P936/P937 N457Q NLT P938/P939

(a) Materials and Methods

For cloning, the pRS5a expression vector was used (FIG. 5). The primers shown in Table 10 were used.

Table 10. Primer sequences Primers Subsequence Description P928 SEQ ID NO: 171 Forward primer to remove the glycosylation site N73Q P929 SEQ ID NO: 172 Reverse primer to remove the glycosylation site N73Q P930 SEQ ID NO: 173 Forward primer to remove the glycosylation site T229A P931 SEQ ID NO: 174 Reverse primer to remove the glycosylation site T229A P932 SEQ ID NO: 175 Forward primer to remove the glycosylation site N292Q P933 SEQ ID NO: 176 Reverse primer to remove the glycosylation site N292Q P934 SEQ ID NO: 177 Forward primer to remove the glycosylation site N327Q P935 SEQ ID NO: 178 Reverse primer to remove the glycosylation site N327Q P936 SEQ ID NO: 179 Forward primer to remove the glycosylation site N371Q P937 SEQ ID NO: 180 Reverse primer to remove the glycosylation site N371Q P938 SEQ ID NO: 181 Forward primer to remove the glycosylation site N457Q P939 SEQ ID NO: 182 Reverse primer to remove the glycosylation site N457Q

For PCR, the QuikChange Lightning site-directed mutagenesis kit (Agilent, no. 210519-5) was used according to the manufacturer's instructions.

The next day, single colonies were selected for DNA extraction in mini-amounts and sequence analysis was performed using forward primer P270 (SEQ ID NO: 165) and reverse primer P271 (SEQ ID NO: 166).

To ensure that the vector backbone was correct (due to mutagenesis), the sequenced fragment of the insert was cloned into a new pRS5a vector backbone (FIG. 5) using the following method.

The vector was generated using a vector backbone of SEQ ID NO: 36 with an expression tag of SEQ ID NO: 135 containing an APP_HIS tag at a stock solution concentration of 3.3 µg/µl.

The vector was digested by mixing 10 μg vector DNA, 0.4 μl HindIII (100 U/μl, NEB), 2 μl EcoRI (20 U/μl, NEB), 5 μl CutSmart buffer at 10x concentration (NEB), H ₂ O to final volume 50 μl. Cleavage was carried out for 3 hours at 37°C.

Dephosphorylation was performed with calf intestinal alkaline phosphatase (CIP, NEB, no. M0290L), 10 U/µl. Immediately after digestion, 3 μl of CIP was added to the digested vector and incubated for 30 min. at 37°C. The cleaved and dephosphorylated vector was loaded onto a preparative 0.8% agarose gel with TAE, and a strip corresponding to the size of the vector c ~ 6100 bp was cut out. Purification was performed using the Wizard® SV Gel and PCR Clean-Up kit, Promega, #9282, eluting with 100 µl in 1 column. The concentration determined by OD at 260 nm was 64 ng/µl.

Cleavage of mutated insert fragments was performed by mixing 42.5 µl of DNA (~3-5 µg per DNA), 5 µl of CutSmart buffer at 10x concentration, NEB #B7204S, 0.4 µl of HindIII-HF, 100 U/µl, NEB # R3104S, 2 µl EcoRI-HF, 20 U/µl, NEB # R3103L, and adjusted to 50 µl with H ₂ O. Digestion was performed for 3 hours at 37° C. in a PCR machine. The cleaved inserts were loaded onto a preparative 0.8% agarose gel with TAE, and a strip corresponding in size to the ~1400 bp vector was cut out. Purification was performed using the Wizard® SV Gel and PCR Clean-Up kit, Promega, #9282, eluting with 30 µl in 1 column. The concentration determined by OD at 260 nm was 1-25 ng/µl.

Ligation (at a ratio of vector:insert ~ 1:10) was performed using a kit for rapid DNA ligation no. K1423 from Thermo Scientific. 4 µl of 5x ligation buffer was mixed with 1 µl of ligase, 2 µl of vector fragment digested with HindIII/EcoRI at stock concentration of 64 ng/µl, 13 µl of insert fragment digested with HindIII/EcoR at stock concentration 1-25 ng/µl. Ligation was performed for 10 minutes at RT.

Transformation was performed by incubating 10 μl of the ligation mixture with 80 μl of chemically competent XL1Blue cells (Novartis, FS/RL) for 30 min. on ice. Heat shock for 45 seconds at 42° C. in an Eppendorf incubator followed by a 2 min incubation. on ice. After that, 1 ml of 2YT medium was added, followed by incubation for 1.5 hours at 37°C on an Eppendorf shaker (800 rpm). The cells were centrifuged for 3 minutes. at 7000 rpm, and the colonies were plated with LB/carbenicillin/glucose, followed by overnight incubation at 37°C.

The next day, single colonies were selected for DNA extraction in mini-amounts and sequence analysis was performed using forward primer P270 (SEQ ID NO: 165) and reverse primer P271 (SEQ ID NO: 166).

The correct sequences were transfected into HEK293 cells according to 7 days of expression and 200 ml scale.

Used the following material:

Human embryonic kidney cells constitutively expressing the SV40 large T antigen (HEK293-T), e.g., ATCC11268

Polyethyleneimine "MAX" MW 40000 (PEI) (Polysciences cat. no. 24765) dissolved in H2O at RT, adjusted to pH 7.05 with NaOH

Serum-free culture medium M11V3 (BioConcept, Switzerland, cat. no. V3-K)

DNA: Obtained with Qiagen DNA Midiprep Kit (#12943) according to vendor recommended protocol

All work with cell cultures for transient transfections was performed using suspension-adapted HEK293-T cells grown in serum-free M11V3 medium.

Cells were grown in Corning shake flasks (Corning, USA) on an orbital shaker (115 rpm) in a humidified CO ₂ incubator at 5% CO ₂ (in flasks containing inoculum).

The cells used were in the exponential growth phase (cell density from 5×10 ⁵ to 3×10 ⁶ /ml) and were characterized by >90% viability.

Transfection was carried out on a small scale (in this case 20/50 or 100 μl) using the cells that were counted and the corresponding number of cells was adjusted to 1.4×10 ⁶ cells/ml using M11V3 medium. A 36% cell suspension was used in the final transfection volume.

A DNA solution (solution 1) was prepared by diluting 1 mg/l of the final volume of DNA in 7% of the final volume of M11V3 and gently mixing. Penicillin/streptomycin was added to the transfection medium after feeding to prevent contamination of the cultures due to DNA not subjected to sterilizing filtration. Then a final volume of 3 mg/l PEI solution was diluted in 7% of the final volume of M11V3 and mixed gently (solution 2). Both solutions were incubated for 5-10 min. at room temperature (RT). After that, solution 2 was added to solution 1 with gentle stirring and incubated for another 5-15 minutes at RT. After incubation, the transfection mixture was added to the cells and the culture was cultured for four hours (115 rpm, 37°C, 5% CO2).

The supernatant was collected after 7 days of expression.

Centrifuged at 4500 rpm, 4°C (Heraeus Multifuge 3 S-R) for 15 min.

Clarified by passing through a 0.22 µm sterile filter (Stericup filter, Thermo Scientific, cat. no. 567-0020).

Achieved purification of the supernatant for further steps. A 1 ml supernatant sample was used for IPC on an Open Access APP column.

The sample vials were 2 ml glass crimp vials, Agilent part number 5182-0543, with 11 mm crimp stoppers, part number 5040-4667.

The protein was purified by immobilized metal ion affinity chromatography (IMAC) on Aekta Pure or Aekta Avant (GE Healthcare) according to the following protocol using a 5 ml HisTrap HP column (GE Life Sciences, order number 17-5248-02). Technical requirements are presented in table 11.

Table 11. IMAC Protocol CV Flow rate (ml/min.) Buffer Balancing 5 5 IMAC A Loading a Sample 3 Cell culture supernatant Washing the column 10 3 IMAC A Elution 10 3 Gradient 0-20% IMAC B 10 3 100% IMAC B Fractionation Fractions of 2 ml

The buffers used were according to Table 12 and Table 13.

Table 12. IMAC A - Equilibration and Wash Buffer Concentration Chemical compound 10 mm _{Na2HPO4 _} 10 mm _{NaH2PO4 _} 500 mm NaCl 20 mm Imidazole (Merck)

Table 13. IMAC B - Elution Buffer Concentration Chemical compound 10 mm _{Na2HPO4 _} 10 mm _{NaH2PO4 _} 500 mm NaCl 500 mm Imidazole (Merck)

The resulting protein in accordance with table 14 was stored.

Table 14. Structures Design Mutation positions C1140 N73A/F365S C1141 T229A/F365S C1142 N292Q/F365S C1143 N334Q/F365S C1144 F365S/N371Q C1145 F365S/N457Q C1058 F365S

(b) Results and their interpretation

Improvement in the properties of the mutant forms in terms of yield and peak of monomers during analytical SEC was not observed. The parent protein (EP14) with an expression tag according to SEQ ID NO: 137 showed the best yield and the highest monomer peak in the assay. The lowest yield as well as the lowest monomer peak was achieved using the N371Q mutant.

6. Example 5: Combinations

In order to try to further improve the properties, some of the mutations introduced according to example 3 above were used in combination in accordance with table 15 below. Mutations are numbered according to amino acid positions in wild-type CD39 shown under SEQ ID NO: 1.

Table 15. Combination of structures Design Mutation 1 Mutation 2 Mutation 3 No mutation Primers SEQID NO: EP14xEP19 365: F->S 424: L->Q 436: H->D P878/P879 SEQ ID NO: 64 EP17xEP19 424: L->Q 436: H->D 412: Y->F 405: K->N P880/P881 SEQ ID NO: 70 EP14xEP17 365: F->S 412: Y->F 405: K->N P880/P881 SEQ ID NO: 60 EP10xEP19_H436D 424: L->Q 436: H->D 319: I->T P882/P883 SEQ ID NO: 62 EP19 without H436D 424: L->Q 436: H->D P884/P885 Sequence not included

(a) Materials and Methods

Primers were applied according to Table 16 .

Table 16. Primers primer Subsequence P878 SEQ ID NO: 183 P879 SEQ ID NO: 184 P880 SEQ ID NO: 185 P881 SEQ ID NO: 186 P882 SEQ ID NO: 187 P883 SEQ ID NO: 188 P884 SEQ ID NO: 189 P885 SEQ ID NO: 190

The PCR reaction was set up using the following pipetting scheme:

5 µl 10x reaction buffer,

1 µl double-stranded DNA template (stock solution concentration 100 ng/µl),

1.5 µl primer 1,

1.5 µl primer 2,

1 µl dNTP mix,

1.5 µl QuickSolution Reagent,

35.5 µl H ₂ O (to a final volume of 50 µl) and

1 µl QuikChange Lightning Enzyme.

The parameters of PCR cycles were used in accordance with Table 17.

Table 17. PCR cycle parameters Number of cycles Temperature Time 1 1 96°C 2 minutes. 2 18 96°C 20 s 60°C 10 s 68°C 3 min. (30 s / t. o.) 3 1 68°C 6 min.

Immediately after the reaction, 2 µl of the DpnI enzyme was added to each reaction mixture, mixed, and incubated for 5 min. at 37°C.

Introduction to ultracompetent cells XL10-Gold by transformation was carried out as follows. Cells were thawed on ice. Used 45 µl per transformation and added 2 µl of B-ME to each vial. Then 3 µl of the PCR product digested with DpnI was added and incubated for 30 min. on ice in 15 ml BD tubes. After that, the samples were subjected to heat shock for 40 seconds and incubated on ice for 2 minutes. Then, 950 μl of SOC medium was added, followed by incubation for 1.5 hours at 37° C. in an incubator shaker. Finally, cells were plated on LB/carbenicillin plates and incubated overnight at 37°C. The next day, individual colonies were selected for DNA extraction in mini-amounts and sequence analysis.

The correct sequences were introduced by transfection into HEK293 cells as described in Example 4.

The protein was purified by immobilized metal ion affinity chromatography (IMAC) as follows. 95 ml of the supernatant was used (~4 ml of the total volume was saved for analysis (IPC)).

Material used

Nickel-NTA agarose, Qiagen, cat. No./ID: 30230, Poly-Prep chromatography columns, empty, BioRad, No. 731-1550, buffer for IMAC A, pH 7.4 (containing 20 mM NaPO ₄ buffer and 50 mM imidazole). Buffer for IMAC B, pH 7.4 (containing 20 mM NaPO ₄ buffer and 300 mM imidazole). TBS (at 10x concentration, diluted to 1x concentration with MilliQ water). Amicon Ultra-4 centrifugal filter unit with Ultracel-10, 10K, UFC801096 membrane.

Process steps

1. Prepare columns using 1 ml of Qiagen nickel-NTA agarose (= 0.5 ml of CV)

2. Balancing with 10 CV IMAC A

3. Loading 15/45 ml SN into the column (collecting material flowing through the column)

4. Wash with 10 CV IMAC A (collect in 15 ml Falcon tube)

5. Elution in 6.5 CV IMAC B

6. Determination of eluate concentration

7. Concentration of 3.5 ml sample to ~400 µl using an Amicon Ultra-4 10K centrifuge filter block

8. Buffer exchange by adding TBS and centrifugation at 5000

Samples were analyzed by analytical SEC using 40 µl of each sample and using protein gel with 12 µl of each sample.

The resulting protein was saved.

(b) Results and their interpretation

The results are shown in Table 18.

Table 18. Summary of results Name Yield (mg/l) IPC (APP, mg/l) Aggregation (% Peak Monomers) EP14xEP19 6.85 4.5 75.1 EP17xEP19 13.35 11.5 68.9 EP14xEP17 17.27 11.5 69.2 EP10xEP19_H436D 7.42 4.3 74.3 EP19 without H436D 8.28 2.5 55.6 EP1xEP17 13.46 13.2 77.4 EP28 7.8 2.8 57.5

Sites for protease

No yield/very low yield was observed when inserting the matriptase site. When using the site for furin, ~40% yield was observed (but at the same time, only 50% of DNA was used for transfection, since it was a co-transfection with a plasmid encoding furin).

IL2 Truncations

All truncations containing aa1-3 produced comparable results, and the result for aa1-3 alone could be slightly lower than the others, but this could be due to variation between samples. Truncation of aa4-12 resulted in a lack of protein expression. No differences were found between the truncations in EP28, which, like all other EP variants, contained a TSS linker between the initial IL2 sequence and the hCD39 protein, was not found.

Combinations

Combinations with EP19 (L424Q) did not lead to a significant improvement in protein expression.

Combinations with EP1 (R113M) showed a lower level of aggregation during analytical SEC. NEG726 was well expressed, but showed the worst aggregation rates compared to all tested variants (~37%). The combination of EP14xEP17 did not result in any additional improvement (F365S+Y412F).

7. Example 6: End Candidate Cloning

The selected clinical candidates shown in Table 19 below were expressed for further testing.

Table 19. Overview of Final Candidates Design Clone Combination IL2 leader sequence Main Sequence 1 EP1xEP14xEP19aa1-3 SEQ ID NO: 137 SEQ ID NO: 233 2 EP1xEP17xEP19aa1-3 SEQ ID NO: 137 SEQ ID NO: 217 3 EP14aa1-3 SEQ ID NO: 137 SEQ ID NO: 229 4 EP17aa1-3 SEQ ID NO: 137 SEQ ID NO: 237 5 EP19aa1-3 SEQ ID NO: 137 SEQ ID NO: 243 6 EP28aa1-3 (leader/
original) SEQ ID NO: 137 SEQ ID NO: 58 7 EP1xEP14xEP19aa1-6 SEQ ID NO: 135 SEQ ID NO: 235 8 EP1xEP17xEP19aa1-6 SEQ ID NO: 135 SEQ ID NO: 219 9 EP14aa1-6 SEQ ID NO: 135 SEQ ID NO: 231 10 EP17aa1-6 SEQ ID NO: 135 SEQ ID NO: 239 eleven EP19aa1-6 SEQ ID NO: 135 SEQ ID NO: 245 12 EP28aa1-6 (leader/
original) SEQ ID NO: 135 SEQ ID NO: 80

The following primers were used.

Table 20. Primers primer Subsequence R113M, matrix SEQ ID NO: 191 R113M straight SEQ ID NO: 192 R113M reverse SEQ ID NO: 193 F330S, matrix SEQ ID NO: 194 F330S straight SEQ ID NO: 195 F330S reverse SEQ ID NO: 196 Y377F matrix SEQ ID NO: 197 L389C, matrix SEQ ID NO: 198 Y377F/L389Q Matrix SEQ ID NO: 199 Straight SEQ ID NO: 200 Back SEQ ID NO: 201 wt SEQ ID NO: 202

The PCR reaction was set up using the following pipetting scheme:

0.25 µl DMSO,

20 ng of vector,

1.5 µl insert (45 ng/µl),

2 µl 5x HF buffer,

0.1 µl Phusion polymerase,

0.08 µl dNTP mix,

10-x µl ddH ₂ O

The parameters of PCR cycles were used in accordance with Table 17.

Table 21. PCR cycle parameters Number of cycles Temperature Time 1 1 98°C 3 min. 2 25 98°C 30 s 60°C 30 s 72°C 5 minutes. 46 s 3 1 72°C 10 min.

Immediately after the reaction, 0.5 μl of DpnI enzyme was added to each reaction mixture, mixed and incubated for 2 hours at 37°C.

Introduction to ultracompetent cells XL10-Gold by transformation was carried out as follows. Cells were thawed on ice. Used 45 µl per transformation and added 2 µl of B-ME to each vial. Then 3 µl of the PCR product digested with DpnI was added and incubated for 30 min. on ice in 15 ml BD tubes. After that, the samples were subjected to heat shock for 40 seconds and incubated on ice for 2 minutes. Then, 950 μl of SOC medium was added, followed by incubation for 1.5 hours at 37° C. in an incubator shaker. Finally, cells were plated on LB/carbenicillin plates and incubated overnight at 37°C. The next day, individual colonies were selected for DNA extraction in mini-amounts and sequence analysis.

All constructs were subcloned into the genetic environment of the new vector to ensure correct sequences. To do this, all constructs were amplified by PCR with the insertion of G4S linkers and followed by digestion with HindIII/EcoRI.

The resulting protein was saved.

8. Example 7: obtaining proteins for comparison

(1) Null mutations

In order to obtain negative control proteins for in vivo studies, one/two mutations were inserted into the original human CD39ΔMIL protein (EP28). These mutations, as described in the literature, eliminated or reduced the enzymatic activity of this protein. The mutations were at positions E174A and S218A.

The following primers were used.

Table 22. Primers primer Subsequence P910 SEQ ID NO: 203 P911 SEQ ID NO: 204 P914 SEQ ID NO: 205 P915 SEQ ID NO: 206

The PCR reaction was set up using the following pipetting scheme:

5 µl 10x reaction buffer,

1 µl double-stranded DNA template (stock solution concentration 100 ng/µl),

1.5 µl primer 1,

1.5 µl primer 2,

1 µl dNTP mix,

1.5 µl QuickSolution Reagent,

35.5 µl H ₂ O (to a final volume of 50 µl) and

1 µl QuikChange Lightning Enzyme.

The parameters of PCR cycles were used in accordance with Table 17.

Table 23. PCR cycle parameters Number of cycles Temperature Time 1 1 96°C 2 minutes. 2 18 96°C 20 s 60°C 10 s 68°C 3 min. (30 s / t. o.) 3 1 68°C 6 min.

Immediately after the reaction, 2 µl of the DpnI enzyme was added to each reaction mixture, mixed, and incubated for 5 min. at 37°C.

Introduction to ultracompetent cells XL10-Gold by transformation was carried out as follows. Cells were thawed on ice. Used 45 µl per transformation and added 2 µl of B-ME to each vial. Then 3 µl of the PCR product digested with DpnI was added and incubated for 30 min. on ice in 15 ml BD tubes. After that, the samples were subjected to heat shock for 40 seconds and incubated on ice for 2 minutes. Then, 950 μl of SOC medium was added, followed by incubation for 1.5 hours at 37° C. in an incubator shaker. Finally, cells were plated on LB/carbenicillin plates and incubated overnight at 37°C. The next day, individual colonies were selected for DNA extraction in mini-amounts and sequence analysis.

The correct sequences were introduced by transfection into HEK293 cells according to the following protocol.

Digestion buffer was prepared using 10 μg vector DNA, 0.4 μl HindIII (100 U/μl, NEB), 2 μl EcoRI (20 U/μl, NEB), 5 μl CutSmart buffer at 10x concentration (NEB) and H ₂ O to a final volume of 50 µl. The cleavage reaction was carried out for 3 hours at 37°C.

Immediately after cleavage, a dephosphorylation reaction was carried out. Bovine intestinal alkaline phosphatase (10 U/µl, CIP, NEB, no. M0290L) was added (3 µl) to the digested vector mixture and incubated for 30 min. at 37°C.

The digested and dephosphorylated vector was subcloned for sequence verification.

The correct sequences were introduced by transfection into HEK293 cells according to the following protocol.

Expression for 7 days was performed using the following material: 1. Human embryonic kidney cells constitutively expressing the SV40 large T antigen (HEK293-T, ATCC11268); 2. Polyethyleneimine "MAX" MW 40000 (PEI) (Polysciences cat. no. 24765).

The PEI solution was prepared by carefully dissolving 1 g of PEI in 900 ml of cell culture water at room temperature (RT). It was then neutralized with NaOH to give a final pH of 7.05. Finally, the volume was adjusted to 1 L and the solution was filtered through a 0.22 µm filter, aliquoted and frozen at -80° C. until further use. A thawed aliquot can be refrozen up to 3 times at -20°C, but should not be stored at -20°C for long periods.

Serum-free culture medium M11V3 (BioConcept, Switzerland, cat. no. V3-K).

All work with cell cultures for transient transfections was performed using suspension-adapted HEK293-T cells grown in serum-free M11V3 medium.

For small-scale transfections (<5 L), cells were grown in Corning shake flasks (Corning, USA) on an orbital shaker (100 rpm) in a humidified CO ₂ incubator at 5% CO ₂ (in flasks containing inoculum). culture).

As a general rule, cells in seed cultures should be in an exponential growth phase (at cell densities between 5x10 ⁵ and 3x10 ⁶ /ml) and have >90% viability. Cell densities outside this range either result in a lag phase after separation or a decrease in transfection efficiency.

For transfection on a small scale (in this case 2 L), an aliquot of cells was taken from seed cultures and adjusted to 1.4×10 ⁶ cells/ml in 36% of the final volume of M11V3 medium.

A DNA solution (solution 1) was prepared by diluting 1 mg/l of the final volume of DNA in 7% of the final volume of M11V3 and gently mixing. To prevent contamination of cultures, this solution can be filtered with a 0.22 µm filter (eg Millipore Stericup). In this case, sterilizing filtration was not carried out due to the small volume. Then a final volume of 3 mg/l PEI solution was diluted in 7% of the final volume of M11V3 and mixed gently (solution 2). Both solutions were incubated for 5-10 min. at room temperature (RT). After that, solution 2 was added to solution 1 with gentle agitation and incubated for another 5-15 minutes at RT (during incubation, do not stir again, as PEI coats/condenses DNA in the form of positively charged particles that bind to anionic residues of the cellular surface and transported into the cell by endocytosis). After incubation, the transfection mixture is added to the cells and the culture is cultured for four hours (10 rpm, 37° C., 6% CO ₂ ).

Finally, the culture is fed with the remaining 50% of the final volume of M11V3 medium according to the following example. Inoculation volume: 36 ml at 1.4×10 ⁶ cells/ml.

Solution 1: 7 ml of M11V3 medium with 100 µg of plasmid DNA. Solution 2: 7 ml M11V3 medium with 300 µg PEI (300 µl).

Make-up: 50 ml M11V3, total volume 100 ml.

The protein was purified by immobilized metal ion affinity chromatography (IMAC) as follows. 95 ml of the supernatant was used (~4 ml of the total volume was saved for analysis (IPC)).

Material used

Nickel-NTA agarose, Qiagen, cat. No./ID: 30230, Poly-Prep chromatography columns, empty, BioRad, No. 731-1550, buffer for IMAC A, pH 7.4 (containing 20 mM NaPO ₄ buffer and 50 mM imidazole). Buffer for IMAC B, pH 7.4 (containing 20 mM NaPO ₄ buffer and 300 mM imidazole). TBS (at 10x concentration, diluted to 1x concentration with MilliQ water). Amicon Ultra-4 centrifugal filter unit with Ultracel-10, 10K, UFC801096 membrane.

Process steps

1. Prepare columns using 1 ml of Qiagen nickel-NTA agarose (= 0.5 ml of CV)

2. Balancing with 10 CV IMAC A

3. Loading 15/45 ml SN into the column (collecting material flowing through the column)

4. Wash with 10 CV IMAC A (collect in 15 ml Falcon tube)

5. Elution in 6.5 CV IMAC B

6. Determination of eluate concentration

7. Concentration of 3.5 ml sample to ~400 µl using an Amicon Ultra-4 10K centrifuge filter block

8. Buffer exchange by adding TBS and centrifugation at 5000

Samples were analyzed by analytical SEC using 40 µl of each sample and using protein gel with 12 µl of each sample.

The resulting protein was saved.

(2) Protein with MIL

EP14aa1-3 was cloned with a membrane interacting loop (aa193-204) and PCR with overlapping primers.

The following primers were used.

Table 24. Primers primer Subsequence Straight SEQ ID NO: 207 Back SEQ ID NO: 208 Reverse for semantic thread SEQ ID NO: 98

The PCR reaction was set up using the following pipetting scheme:

1.2 µl Phusion Hot Start Polymerase,

24 µl 5x HF buffer,

0.96 µl 100 mM dNTP (25 mM each dNTP),

0.6 µl forward primer,

0.6 µl reverse primer,

92.64 µl H ₂ O treated with DEPC.

The parameters of PCR cycles were used in accordance with Table 17.

Table 25. Parameters of PCR cycles Number of cycles Temperature Time 1 1 98°C 30 s 2 thirty 98°C 10 s Gradient 50-70°C 30 s 72°C 30 s 3 1 72°C 10 min.

Immediately after the reaction, 2 μl of DpnI enzyme was added to each reaction mixture, mixed and incubated for 2 hours at 37°C.

Transformation was performed by transferring 2 μl of the PCR product to a 96-well PCR plate and cooling on ice. 20 µl of chemically competent STELLAR bacteria were added and mixed gently by pipetting up and down once. Samples were incubated for 30 minutes on ice and then for 45 seconds at 42°C in a PCR instrument, then incubated again for 60 seconds on ice. Finally, 90 μl of SOC medium was added and incubated for 1 hour at 37°C. The entire transfection mix was seeded onto LB/ampicillin or LB/carbenicillin plates and grown overnight at 37°C.

The resulting EP14 protein with MIL with the amino acid sequence according to SEQ ID NO: 155 was saved.

9. Example 8: enzymatic activity

Characteristics of the candidates obtained in the previous examples were obtained using the analysis of enzymatic activity.

The following reagents were used: Pi-free buffer, phosphate-free saline (140 mM NaCl, 5 mM KCl, 1 mM MgCl2, 2 mM CaCl2, 10 mM Hepes, pH 7.4); and Pi-free + 2% BSA buffer, phosphate-free saline with 20 mg/ml BSA; CD39 protein (according to SEQ ID NO: 1); ATP.

The CD39 solution was prepared in duplicate at a concentration of 2 μg/ml. The ATP solution was prepared in duplicate at a concentration of 1000 mM from 15 μl of the stock solution of ATP+1185 μl of buffer, and its total volume was 1.2 ml.

The enzymatic reaction was studied by mixing 60 µl of ATP with 60 µl of CD39 or 60 µl of Pi-free buffer as a control in 48-well PCR plates filled with 120 µl of final solution/well. The final concentration was 500 μM for ATP and 1 μg/ml for CD39.

Samples were incubated at 37°C for 0, 5, 15, 30, 60, 90 and 150 minutes, respectively. The samples were then evaluated by Pi release assay or HPLC.

(1) Pi release analysis

(a) Materials and Methods

Reagents were prepared using a standard Pi detection kit according to the manufacturer's instructions.

A calibration curve for Pi was obtained by dilution in water. A 1:2 serial dilution of Pi stock solution (100 μM) was prepared: 450 μl + 450 μl water. The concentration according to the calibration curve was 50 μM/25 μM/12.5 μM/6.25 μM/3.1 μM/1.5 μM/0 μM.

Received a mixture of reagents Gold: 4 ml reagent Gold+40 μl of the accelerator (for 3 tablets). In a 96-well plate, the samples were diluted 1:10 in H ₂ O (water dilution: 10 µl sample+90 µl H2O). 50 μl of the 1:10 diluted sample was dispensed into each well of a 96-well half-well plate (Corning, 3690). 12.5 μl of the Gold reagent mix was added to each well (25% sample volume) and the samples were incubated for 10 minutes at room temperature. Absorption values were read at 635 nm.

(b) Results and their interpretation

Comparative results for candidates are shown in Table 26.

Table 26. Comparative results for candidates Design Initial sequence of IL-2 SEQID NO: Exit after ALC % monomers after ALC Melting point (°C) Enzymatic activity in vitro (relative to EP28) 1 EP14aa1-3 SEQ ID NO: 137 SEQ ID NO: 229 33.1 83.8 62 4 2 EP1xEP14aa1-3 SEQ ID NO: 137 SEQ ID NO: 221 3.7 50.6 65.5 4 3 EP1xEP17aa1-3 SEQ ID NO: 137 SEQ ID NO: 211 95.8 91.9 61 1.5 4 EP17xEP19aa1-3 SEQ ID NO: 137 SEQ ID NO: 227 3.5 38.9 60.5 1.5 5 EP1xEP17xEP19aa1-3 SEQ ID NO: 137 SEQ ID NO: 217 153.2 89.7 60.75 1.5 6 EP1aa1-3 SEQ ID NO: 137 SEQ ID NO: 209 6.0 9.2 59.75 1 7 EP1xEP14aa1-6 SEQ ID NO: 135 SEQ ID NO: 223 148.8 91.8 64 4 8 EP1xEP17aa1-6 SEQ ID NO: 135 SEQ ID NO: 213 59.4 86.1 59.5 1.5 9 EP17xEP19aa1-6 SEQ ID NO: 135 SEQ ID NO: 227 2.7 13.7 60 1.5 10 EP1xEP17xEP19aa1-6 SEQ ID NO: 135 SEQ ID NO: 219 30.9 88.4 60.75 1.5 eleven EP1xEP17_K405Naa1-15 SEQ ID NO: 133 SEQ ID NO: 215 156.3 86.4 62.25 1.5 12 EP28aa1-3 SEQ ID NO: 137 SEQ ID NO: 58 2.7 10 60.5 1 13 EP28aa1-16 SEQ ID NO: 131 SEQ ID NO: 72 4.7 45 61.8 1

Enzymatic activity was measured by adding 500 μM ATP to the enzyme and analyzing the concentration of ATP, ADP, AMP by HPLC (method description below) over time. The obtained kinetic curves were approximated by the model shown in figure 6 to obtain the constants of enzymatic reactions. According to the enzymatic reaction constant Kcat, the enzymes were arranged in the following order (from low activity to high activity): EP28 (wt), EP17, EP14, EP15.

Figure 7 shows kinetic data and model fit for EP28. Figure 8 shows kinetic data and model fit for EP14. Figure 9 shows kinetic data and model fit for EP15.

An overview of the enzymatic reaction constants for EP28 (wt), EP14, EP15 and EP17 is shown in Table 27 . Compared to the wild-type (WT) variant, the three new variants showed increased catalytic activity. Importantly, the new variants showed a clear increase in catalytic rate constant (kcat) and catalytic efficiency (kcat/Km). Because reported substrate concentrations of ATP and ADP during tissue injury and thrombosis exceed the reported Km value, this increase in kcat and kcat/Km is likely to translate into higher in vivo activity.

Table 27. Enzymatic reaction constants ATP -> ADP+P ADP -> AMP+P inhibition k ^T _cat K ^T _M k ^T _cat /K ^T _M k ^D _cat K ^D _M k ^D _cat /K ^D _M K ^M _d wt 65.3 0.7 89.7 40.0 0.1 400.3 0.2 EP14 380.2 1.1 352.6 90.3 Fixed at 0.1 903.0 556.8 EP15 734.9 1.1 658.1 128.7 0.1 1287.1 584.9 EP17 180.7 1.0 178.1 67.0 0.1 670.0 3.0

(2) Validation analysis by HPLC method (kinetic characteristics and dose-response)

(a) Materials and Methods

Candidates were tested using HPLC validation analysis. 70 μl of each sample was transferred into glass vials for HPLC.

Calibration samples were prepared using the 5 mM stock solutions shown in Table 28 .

Table 28. Stock solutions 5 mm Weight _H2O adenosine 1336.2 µg/ml 1.862 mg 1394 µl Inosine 1341.2 µg/ml 2.668 mg 1989 µl AMP 1736.1 µg/ml 2.182 mg 1257 µl ADP 2506.6 µg/ml 2,500 mg 997 µl ATP 2755.7 µg/ml 4.834 mg 1754 µl

1000 µM 20 µl of each stock solution was mixed in an HPLC vial

500 µM 20 µl 1 mM+20 µl H ₂ O

100 µM 10 µl 1 mM+90 µl H ₂ O

10 µM 10 µl 100 µM+90 µl H ₂ O

1 µM 10 µl 10 µM+90 µl H ₂ O

HPLC separations were performed using an Agilent 1100 system with capillary pump (G1376A), degasser (G1379A), ALS (G1329A), thermostat (G1330B), column compartment (G1316A), and DAD (G1315A). Solvent A: 10 mM KH ₂ PO ₄ (04243, Riedel-de Haën) + 2 mM TBA bromide, pH 7.0 (86857-10G-F, Fluka) and Solvent B: 10 mM KH2PO4/ACN 1/1+2 mM TBA bromide, pH 5.5. Column: Nucleodur 300-5 C18 EC, 2×150 mm, 5 µm, Macherey-Nagel 760185.20, lot E14100258 36654055. Column temperature was 40°C, injection volume was 10 µl, flow rate was 0.3 ml/min. , and the gradient was 0-3': 0% B; 3-23': 0-95% B, linear; 23-28': 95% B, linear; 28-29': 95-0% B, linear; 5' - break time before the next analysis. DAD: 247 nm and 259 nm.

UPLC separation was performed using Waters class I UPLC. Solvent A: 10 mM KH ₂ PO ₄ /10 mM K ₂ HPO ₄ 1/1 + 2 mM TBA bromide, pH 7.0. Solvent B: 10 mM KH ₂ PO ₄ /ACN 1/1+2 mM TBA bromide, pH 5.5. Column: Fortis Bio C18, 2.1×50 mm, 5 µm, di2chrom BIO318-020301 SN H03161210-2. The column temperature was 40° C., the injection volume was 10 μl, the flow rate was 0.5 ml/min, and the gradient was 0-1': 0% B; 1-8': 0-55% B, linear; 8-10': 55% B; 10-11': 55-0% B, linear; 14' - stop time. DAD worked at 247 nm and 259 nm.

(b) Results

The results can be seen in Figures 7, 8, 9 and 11 showing kinetic data and model fit for candidates according to various embodiments.

10. Example 9: in vitro activity, initial screening

The CD39 variants EP1 to EP24 described in the previous examples were cloned into the mammalian expression vector pRS5a_leader_APP_His (Figure 5) without the IL2 leader sequence and without the initial IL2 sequence.

(a) Materials and Methods

EP hits were expressed on a small scale (20/50 ml scale) in HEK293 (transfection using PEI) for 7 days followed by IPC with APP-HPLC (as described above).

Protein purification from 15/45 ml cell culture supernatant using Ni-NTA columns (0.5 ml CV);

Elute with 6 CV of IMAC B buffer (20 mM NaPO4 buffer, 300 mM imidazole, pH 7.4);

Concentration and re-buffering of the purified protein in TBS, pH 7.4;

Protein gel analysis using analytical SEC method;

Delivery of all variants and three controls (stock hCD39-dMIL, or EP28, with and without initial IL2 sequence and 8M variant without initial IL2 sequence): 90-200 µl of purified protein in TBS, pH 7.4

(b) Results and their interpretation

The results are summarized in Table 29 below.

All samples were in TBS, pH 7.4, and labeled APP (SEQ ID NO: 247) and His (SEQ ID NO: 249).

Only the original human CD39ΔMIL (EP28) had an initial 15 amino acid IL2 sequence, aa1-15 (SEQ ID NO: 133).

Pi release analysis BOENKTH1-0252824, dual detection for 60 and 180 min values.

Table 29. In vitro activity Pi release assay, 0.25 µg/mL+500 µM ATP Date of cleaning Name Concentration
[mg/ml] Concentration
[micromolar] Overall volume
[ml] 0 min. Average value after 60 min. Average value after 180 min. 06/17/2016 EP1 0.19 3.7 0.11 10.35 20.90 45.99 06/14/2016 EP2 0.15 2.8 0.10 11.35 23.65 53.92 06/14/2016 EP3 0.11 2.2 0.10 8.92 19.22 40.76 06/14/2016 EP4 0.25 4.8 0.10 7.99 18.59 37.47 06/14/2016 EP5 0.11 2.1 0.10 17.36 39.59 72.09 06/17/2016 EP6 0.14 2.7 0.15 11.57 32.73 69.63 06/21/2016 EP7 0.41 7.8 0.11 9.47 21.19 43.68 06/21/2016 EP8 0.31 5.9 0.11 7.92 15.23 33.94 06/14/2016 EP9 0.15 2.9 0.10 5.56 13.39 31.38 06/21/2016 EP10 0.33 6.3 0.11 9.32 21.91 54.07 06/14/2016 EP11 0.23 4.4 0.10 10.24 21.27 46.21 06/21/2016 EP12 0.37 7.1 0.11 10.55 21.99 50.80 06/21/2016 EP13 0.13 2.5 0.11 4.93 3.13 3.54 06/21/2016 EP14 0.34 6.5 0.11 19.07 66.35 104.80 06/14/2016 EP15 0.19 3.7 0.10 11.11 29.26 89.92 06/14/2016 EP17 0.28 5.3 0.10 12.49 30.30 102.81 06/14/2016 EP18 0.15 2.9 0.10 3.91 9.70 23.49 06/17/2016 ep19 0.55 10.6 0.12 14.36 26.38 69.93 06/14/2016 EP20 0.14 2.7 0.10 3.36 2.22 3.60 06/14/2016 EP21 0.22 4.2 0.10 7.17 16.37 24.27 06/17/2016 EP22 0.17 3.3 0.11 8.06 15.33 37.30 06/21/2016 EP23.1 0.28 5.4 0.11 12.62 23.58 62.78 06/17/2016 EP24 0.10 2.0 0.19 3.10 3.45 4.83 06/14/2016 Parent EP25 hCD39-dMIL 0.23 4.4 0.10 4.98 11.46 24.30 06/17/2016 EP26 hCD39-8M 0.19 3.7 0.15 3.66 8.41 24.15 06/17/2016 Parent EP28-IL2-initial-hCD39 2.19 42.0 0.14 10.25 23.48 52.73 06/21/2016 EP1-repeated 0.49 9.5 0.11 10.03 17.84 40.33 06/17/2016 EP2-repeated 0.55 10.6 0.12 12.80 28.22 66.88 06/17/2016 EP3-repeated 0.56 10.8 0.12 18.05 33.35 79.53 06/17/2016 EP4-repeated 0.61 11.7 0.16 15.98 29.47 68.39 06/17/2016 EP5-repeated 0.66 12.6 0.15 25.53 46.10 91.32 06/21/2016 EP23.4 0.29 5.5 0.11 10.43 22.45 56.53

11. Example 10: in vitro activity, refined screening

A subgroup of 12 mutants was tested a second time, but with an initial IL-2 sequence allowing for greater scale expression.

(a) Materials and Methods

Mammalian expression vector pRS5a_APP_His leader with 15 amino acid initial IL2 sequence - aa1-15 (SEQ ID NO: 133) (Figure 5). Expression of EP hits on a small scale (50/100 ml scale) in HEK293 (transfection using PEI) for 7 days followed by IPC with APP-HPLC (as described above).

Protein purification from 45/95 ml cell culture supernatant using Ni-NTA columns (0.5 ml CV)

Elute with 6 CV of IMAC B buffer (20 mM NaPO4 buffer, 300 mM imidazole, pH 7.4)

Concentration and re-buffering of the purified protein in TBS, pH 7.4

Protein Gel Analysis by Analytical SEC

Delivery of all variants and controls (original hCD39-dMIL, or EP28, with initial IL2 sequence aa1-15 (SEQ ID NO: 133)):

500 µl purified protein in TBS, pH 7.4

(b) Results and their interpretation

The results are summarized in table 30, table 31 and table 32 below.

Table 30. Protein purification for EP hits 07/06/2016, part 1 Name Concentration
[mg/ml] Concentration
[micromolar] Overall volume
[ml] Yield/46 or 16 ml
[mg] Yield (mg/l) IPC (APP, mg/l) EP2 0.64 12.3 0.5 0.32 7.13 6.9 EP3 0.72 13.9 0.5 0.36 8.02 8.6 EP4 0.86 16.4 0.5 0.43 9.49 8.6 EP5 0.89 17.0 0.5 0.44 9.84 10.1 EP6 0.40 7.7 0.5 0.20 4.46 4.3 EP9 0.57 11.0 0.5 0.29 6.35 6.0 EP11 0.74 14.2 0.5 0.37 8.18 8.3 EP12 0.85 16.3 0.5 0.42 9.40 8.2 EP14 0.82 15.7 0.5 0.41 9.09 7.8 EP17 0.94 18.0 0.5 0.47 13.04 13.3 EP18 0.70 13.4 0.5 0.35 7.75 6.4 EP24 0.65 12.4 0.5 0.32 8.99 10.8 EP28 with IL2 initial sequence 0.27 5.2 0.5 0.14 9.01 6.6

Table 31. Protein purification for EP hits 07/06/2016, part 2 Name Expression volume (ml) Aggregation (%) (Analytical SEC) Peak monomers (%)
(Analytical SEC) Destruction (%)
(Analytical SEC) Pi assay: 1 µg/mL enzyme, 500 µM ATP, 60 min. (1:10) EP2 50 15.7 69.5 14.9 53.572 EP3 50 14.9 67.6 17.5 62.6725 EP4 50 11.3 72.5 16.3 52.1195 EP5 50 15.1 67.8 17 75.1995 EP6 50 17.2 59.3 23.5 72.517 EP9 50 21.7 57.5 20.8 63.7175 EP11 50 12.3 72.2 15.6 59.0205 EP12 50 19.9 63.1 17.1 48.358 EP14 50 14.9 66.6 18.5 88.3785 EP17 40 17.3 68.9 13.8 89.8415 EP18 50 15.4 67.2 17.4 61.495 EP24 40 8.9 73 18 74.713 EP28 with IL2 initial sequence 20 17.8 56.4 25.8 53.6735

Table 32. Protein purifications for EP hits 07/15/2016 Name MW
[kDa] E
[M-1*cm-1] Concentration
[mg/ml] Concentration
[micromolar] Overall volume
[ml] Quantity delivered Expression volume (ml) EP8 52.08 70875 0.02 0.5 0.5 0.01 50 EP10 52.08 70875 0.76 14.7 0.5 0.38 50 EP14 52.08 70875 0.21 4.0 0.5 0.10 50 EP15 52.08 70875 0.81 15.6 1 0.81 100 EP17 52.08 70875 0.22 4.3 0.5 0.11 40 ep19 52.08 70875 1.10 21.2 0.5 0.55 50 EP23 52.08 70875 0.46 8.8 0.5 0.23 50 Control parent EP28 52.08 70875 0.77 14.7 1 0.77 100

Table 33. Point mutations in relation to the wild-type CD39 sequence according to SEQ ID NO: 1. Number of mutations Mutation position 1 Mutation position 2 Mutation position 3 Mutation position 4 Found sequence Pi assay: 1 µg/mL enzyme, 500 µM ATP, 60 min, 1:10 1 151: V->A 2x 4.309 1 319: I->T 2x 54.866 1 365: F->S unique 69.0195 4 292: N->K 365: F->S 424: L->P 463: P->S unique 78.81 2 405: K->N 412: Y->F unique 89.415 2 424: L->Q 436: H->D unique 62.912 4 254: L->M 263: W->R 439: F->S 469: S->R unique 88.282

12. Example 11: in vivo activity, pK

(a) Materials and Methods

To determine PK properties in vivo, 10 mg/kg of the compound at a final concentration of 10 mg/ml in PBS buffer was administered intravenously (1 ml/kg) via the tail vein to 4 conscious female C57BL/6 mice. The mice were obtained from WIGA and weighed about 22 g. All work with living organisms was carried out in accordance with Swiss animal rights law.

Whole blood was collected (50 μl at each time point) at 0.25, 3, 8, 24, and 48 hours post-dose in low-volume serum tubes using the Minivette POCT. Serum was separated and used to determine the concentration.

Gyrolab technology is an automated nanoliter-scale immunoassay using an affinity flow format that is performed by centrifugal force and detection by laser-induced fluorescence. The streptavidin-coated beads were pre-packed into affinity chromatography columns in Gyrolab Bioaffy CD. Each CD contained 112 columns. The affinity capture columns contained 15 nL per microstructure. The introduced samples entered inside under the action of the capillary effect. The biotinylated capture reagent bound to the streptavidin-coated beads. An analyte solution was then injected, which bound to the capturing molecules. Finally, a developing reagent labeled with a fluorophore was used. In the case of CD39, two different readings were used in the analysis depending on the presence of the APP label.

1) Anti-CD39 antibody (40035) and anti-APP antibody (27431) are shown in Figure 10A.

2) Fab (40035) and a 1:1 anti-Fc/anti-CD39 antibody (40044) premix (all EP28aa1-16 constructs) are shown in Figure 10B. Antibody 40044 loses activity upon biotinylation through binding to the amino group, therefore, only antibody 40035 was biotinylated.

All calibration curves for CD39 constructs were diluted in Rexxip A containing 5% (v/v) mouse serum in a 1:2 dilution series. The applicable concentration range for APP labeled constructs was 5000 ng/mL to 9.77 ng/mL and for EP28aa1-16 it was 10000 ng/mL to 9.77 ng/mL. All mouse serum samples were diluted 1:100 in Rexxip A containing 5% (v/v) mouse serum. Samples of CD39 QC constructs were diluted in Rexxip A containing 5% (v/v) mouse serum (50 and 500 ng/ml for APP-labeled constructs and 500 and 1000 ng/ml for EP28aa1-16). The final concentration for all biotinylated capture reagents was 0.1 mg/mL and the fluorescently labeled detection antibody was diluted to 10 nM in Rexxip F.

(b) Result and its interpretation

The results are summarized in Table 33. As can be seen, all candidates exhibited the same PK properties. Therefore, the selection of a candidate was not made on the basis of PK-properties.

Table 34. pK values Design SEQID NO: Animal 1 Animal 2 Animal 3 Animal 4 Average t/2 (days) EP28aa1-16 SEQ ID NO: 72 1.1 1.3 1.0 1.1 1.1 EP1xEP14aa1-6 SEQ ID NO: 223 0.9 0.7 0.7 0.3 0.7 EP28aa1-3 SEQ ID NO: 58 0.6 0.7 0.9 0.8 0.8 EP14aa1-3 SEQ ID NO: 229 0.7 1.0 0.6 1.1 0.9 EP14aa1-6 SEQ ID NO: 231 0.7 0.7 0.7 0.8 0.7 EP17aa1-3 SEQ ID NO: 237 0.9 0.8 0.9 0.8 0.9 EP17aa1-15 SEQ ID NO: 241 0.8 0.9 0.9 0.6 0.8

13. Example 12 In Vivo Activity, AKI Model

(a) Materials and Methods

Nephrectomy of the right kidney was performed before the onset of the clinical situation I/R. The second kidney was removed to avoid the action of compensatory mechanisms that completely change the dynamics of biological processes. Anesthetized animals breathing spontaneously were placed on a homeothermic blanket of a homeothermic monitoring system and covered with sterile gauze. Body temperature was recorded using a rectal probe and controlled in the range from 36.5 to 37.5°C to avoid hypothermia. Animals were anesthetized, shaved and disinfected (betaseptic). After making a midline incision/laparotomy, the contents of the abdominal cavity were moved to the left and the right kidney was removed. The ureter and blood vessels were severed and ligated (9-0 Ethicon), then the kidney was removed.

Induction of I/R injury: Immediately after nephrectomy of the right kidney, the contents of the abdominal cavity were moved to the right and the left renal artery was cut off to induce renal ischemia.

Microaneurysm clips were used to clamp the vascular pedicle to block blood flow to the kidney and induce renal ischemia. The duration of renal ischemia was counted from the moment the clamp was applied. The occurrence of ischemia was confirmed by a change in the color of the kidney from red to dark purple in a few seconds. After induction of ischemia, the microaneurysm clips were removed and a red color change of the kidney indicated reperfusion.

(b) Result and its interpretation

The result is shown in Figure 12. The candidates showed a dose-dependent in vivo response that correlated with their in vitro specific activity. Figure 12A shows the results for the original EP28, Figure 12B shows the results for EP1xEP17, and Figure 12C shows the results for EP14. As can be seen, EP28 and EP1xEP17 show similar dose-dependent responses, with EP14 with higher in vitro activity showing full efficacy at a lower dose.

14. Example 13: Title, Yield, and Development Opportunity

For the purposes of manufacturing selected candidates on a commercial scale, it is important to be able to express them in relatively high yield. For therapeutic proteins, this task may be less straightforward than with therapeutic antibodies due to the complexity of the format, in addition to the lack of an enrichment technology that allows selection of highly productive clones.

Both candidates, EP14aa1-3 and EP28aa1-3, had comparable technical characteristics, which presented a challenge. In particular, low expression titers from earlier expression batches (data not shown) affect production costs or may be even lower after scale-up because control of host cell proteins is not reliable.

In order to attempt to improve protein expression by early selection of clones for both candidates, the development of an individual purification method was required. For this, pools of cells expressing candidates EP28aa1-3 and EP14aa1-3 were obtained.

The original CHO cell line was used as a host cell line to obtain a cell line expressing EP28aa1-16/EP14aa1-3. The host cell line was derived from the CHO-K1 cell line, well known to the person skilled in the art, by the method described, for example, in patent applications WO2015092737 and WO2015092735, both of which are incorporated herein by reference in their entirety. One vial of the CHO line was used to generate a recombinant cell line expressing EP28aa1-16/EP14aa1-3.

The cells were grown in a culture medium with a specific chemical composition. For each transfection, one μg of plasmid DNA, linearized with SwaI, an expression vector encoding EP28aa1-16/EP14aa1-3, was added. The transfection reaction was carried out in a culture medium with a specific chemical composition.

Transfections were performed by electroporation using the AMAXA Gene Pulser system according to the manufacturer's instructions. The original CHO cells used for transfection were in an exponential growth phase with cell viability greater than 95%. A total of three transfections were performed using 5×10 ⁶ cells for each transfection. Immediately after transfection, the cells were transferred to shake flasks containing culture medium with a defined chemical composition.

Cell pools were incubated for 48 hours at 36.5°C and 10% CO ₂ before starting the selection process. The selection procedure was carried out using a selectable marker encoded by the expression vector. 48 hours after transfection and growth under low folate conditions, additional selective pressure was applied by adding 10 nM MTX to the chemistred culture medium. 21 days after the start of selection with MTX, pool populations appeared, consisting predominantly of cells resistant to MTX. After the pools were removed, the cells were frozen. To determine the concentration of EP28aa1-16/EP14aa1-3, standard fed-batch batches were formed in a culture medium with a specific chemical composition. Reverse phase chromatography (RPC) was used to determine the product concentration. Pools of CHO cells producing EP28aa1-16/EP14aa1-3 were used in a FACS single cell sorting/cell printing procedure to obtain individualized clonal cell lines.

15. Example 14: therapeutic application

Graft _- versus-host disease is enhanced by extracellular ATP activating P2X ₇ R. Nature Medicine 16:12, pages 1434-1439 (2010).)

In addition, both in vitro and in vivo studies indicate that CD39 is an apyrase important for cardiovascular function through the regulation of ADP levels. Apyrase is known to inhibit platelet aggregation by metabolizing extracellular ADP.

Human apyrase does not covalently bind to platelets compared to other therapies such as clopidogrel (Plavix™), which binds irreversibly to the ADP receptor on the platelet surface. This allows faster resolution of therapeutic blockade and therefore a safer approach to managing patients with excessive platelet activation. This provides a safer approach to managing patients with excessive platelet activation.

Thus, there is a clear rationale for the therapeutic use of compounds that reduce extracellular ATP levels, such as the compounds of the present invention.

Specific non-limiting examples of therapeutic routes for the compounds of the present invention are acute organ injury due to trauma and/or hypoxia, such as acute respiratory distress syndrome (ARDS), lung injury, renal failure, acute kidney injury (AKI), including acute kidney injury after coronary artery bypass grafting, delayed graft function after transplantation (including xenotransplantation) of a kidney or other solid organs, or vascular disease such as vascular occlusive disease, transplantation and xenotransplantation, treatment of individuals suffering from stroke, coronary artery disease or injury resulting from myocardial infarction, atherosclerosis, arteriosclerosis, embolism, preeclampsia, angioplasty, vascular injury, transplantation, neonatal hypoxic-ischemic encephalopathy, platelet-associated ischemic disorders, including lung ischemia, coronary ischemia and cerebral ischemia, ischemia-reperfusion injury (IRI), thrombotic disorders, including coronary artery thrombosis, cerebral artery thrombosis, intracardiac thrombosis, peripheral arterial thrombosis and venous thrombosis, delayed graft function after transplantation (including xenotransplantation) of the kidney or other solid organs. Other non-limiting examples of therapeutic uses for the compounds of the present invention are the treatment of burns or radiation injury, sepsis, improvement of wound healing, reduction of bleeding or risk of bleeding, prevention of organ damage, graft versus host disease, or prevention of transplant rejection.

Particularly preferred therapeutic routes for the compounds of the present invention are acute kidney injury (AKI), such as acute kidney injury following coronary artery bypass grafting or sepsis or rhabdomyolysis. This condition increases patient mortality and there is no standard of care (SoC) for it. The main causes of AKI in the intensive care unit are: sepsis (47.5%), major surgery (34%), cardiogenic shock (27%), hypovolemia (26%), and exposure to nephrotoxic compounds (19%). In addition, AKI is an independent major risk factor for chronic kidney disease (CKD). Acute kidney injury develops in 20-30% of patients after major heart surgery. Another preferred embodiment relates to the use of the isolated apyrase of the present invention for the treatment of acute kidney injury associated with cardiac surgery.

In another embodiment, the present invention provides an isolated apyrase of the present invention for use in the treatment of delayed graft function (DGF), acute respiratory distress syndrome (ARDS), acute myocardial infarction (AMI), traumatic brain injury (TBI)/acute ischemic stroke (AIS) or combinations thereof, often referred to as forms of multiple organ failure (MOF).

16. Acute kidney injury (AKI) is a common complication of sepsis. AKI develops in 28% of patients with sepsis. In a further preferred embodiment, the present invention relates to the use of the isolated apyrase of the present invention for the treatment of acute kidney injury associated with sepsis. Example 15 Therapeutic Compositions

Therapeutic proteins are usually formulated either in an aqueous form ready for administration or as a lyophilisate for reconstitution with a suitable diluent prior to administration. The protein can be formulated either as a lyophilisate or as an aqueous composition, for example in pre-filled syringes.

A suitable formulation may be an aqueous pharmaceutical composition or lyophilisate which can be reconstituted to provide a solution with a high concentration of the therapeutic protein active ingredient and a low level of protein aggregation for delivery to a patient. High protein concentrations are useful because they reduce the amount of material that must be delivered to the patient (dose). Reduced dosing volumes minimize the time it takes to deliver a fixed dose to a patient. Aqueous compositions of the present invention with a high concentration of proteins are particularly suitable for subcutaneous administration.

Thus, the present invention provides an aqueous pharmaceutical composition suitable for administration to a subject, for example, for subcutaneous administration, containing a therapeutic protein.

The therapeutic protein may be used as a pharmaceutical composition when combined with a pharmaceutically acceptable carrier. In addition to the therapeutic protein, such a composition may contain carriers, various diluents, excipients, salts, buffers, stabilizers, solubilizers, and other materials well known in the art. The characteristics of the carrier will depend on the route of administration. Pharmaceutical compositions for use in the disclosed methods may also contain additional therapeutic agents for the treatment of the particular target disorder.

17. Example 16: route of administration

Typically, the proteins of the present invention are administered by injection, for example intravenously, intraperitoneally, or subcutaneously. Methods for carrying out this administration are known to those of ordinary skill in the art. It may also be possible to prepare compositions that can be administered topically or orally, or that can be mucosally penetrable. One skilled in the art will appreciate that any suitable means of administration suitable for the particular route of administration chosen may be used.

Examples of possible routes of administration include parenteral (eg, intravenous (I.V., or IV), intramuscular (IM), intradermal, subcutaneous (S.C., or SC) or infusion), oral and pulmonary (eg, inhalation), nasal, transdermal (topical) , transmucosal, intra-arterial, continuous infusion and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous administration may contain the following components: a sterile diluent such as water for injection, saline, fixed oils, polyethylene glycols, glycerin, propylene glycol, or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates; and agents for the regulation of tonicity such as sodium chloride or dextrose. The pH can be adjusted with acids or bases such as hydrochloric acid or sodium hydroxide. The parenteral formulation may be sealed in ampoules, disposable syringes or multi-dose vials made of glass or plastic.

Apyrase therapy can be initiated by administering a "loading dose" of the proteins of the present invention to a subject in need of therapy. By "loading dose" is meant the initial dose of proteins of the present invention that is administered to a subject where the dose of proteins of the present invention administered is in the higher dose range. The "loading dose" can be administered as a single administration, for example, a single infusion, in which the proteins are administered IV, or as multiple administrations, for example, multiple infusions, in which the proteins are administered IV, provided that the full "loading dose" is administered in over a period of approximately 24 hours (or within the first month if multiple intravenous injections are needed, depending on the severity of the disease). Following administration of a "loading dose", the subject is then administered one or more additional therapeutically effective doses of the proteins of the present invention. Subsequent therapeutically effective doses may be administered, for example, according to a weekly dosing regimen or once every two weeks, once every three weeks, or once every four weeks. In such embodiments, subsequent therapeutically effective doses are typically in the lower dose range.

Alternatively, in some embodiments, following the administration of a "loading dose", subsequent therapeutically effective doses of the protein of the present invention are administered according to a "maintenance regimen", wherein the therapeutically effective dose of the proteins of the present invention is administered once a month, once every 6 weeks, once every two months, once every 10 weeks, once every three months, once every 14 weeks, once every four months, once every 18 weeks, once every five months, once every 22 weeks, once at six months, once every 7 months, once every 8 months, once every 9 months, once every 10 months, once every 11 months, or once every 12 months. In such embodiments, therapeutically effective doses of the proteins of the present invention are in the lower dose range, in particular if subsequent doses are administered at shorter intervals, for example, from once every two weeks to once a month, or in range of higher doses, in particular if subsequent doses are administered at longer intervals, for example when subsequent doses are administered at intervals of one month to 12 months.

The time frame for dosing is generally measured from the day the first dose of the active compound is administered, which is also known as "baseline". However, different physicians use different naming conventions.

It should be noted that week zero may be referred to as week 1 by some physicians, while day zero may be referred to as day one by some physicians. Thus, it is possible for different physicians to designate, for example, a dose to be administered during week 3/day 21, during week 3/day 22, during week 4/day 21, during week 4/day day 22, referring to the same dosing regimen. For purposes of consistency, the first week of dosing will be referred to herein as week 0, with the first day of dosing referred to as day 1. However, one of ordinary skill in the art will appreciate that this naming convention is used merely for consistency and should not be construed as limiting. i.e. weekly dosing is the provision of a weekly dose of protein, regardless of whether the physician refers to a particular week as "week 1" or "week 2". An example of the dosing regimens referred to herein are in figures 1 and 2. It should be understood that the dose does not have to be given at a precise point in time, for example, a dose to be administered around day 29 could be given, for example, at the period from day 24 to day 34, for example, on day 30, provided that it is provided in the corresponding week.

As used herein, the phrase "a container containing a sufficient amount of protein to allow delivery of the [designated dose]" is used to mean that a given container (e.g., vial, pen, syringe) accommodates a volume of protein (e.g., as part of a pharmaceutical composition) that can be used to provide the desired dose. As an example, if the required dose is 500 mg, then the clinician may use 2 ml from a container that contains a 250 mg/ml protein formulation, 1 ml from a container that contains a 500 mg protein formulation. /ml, 0.5 ml from a container that contains a 1000 mg/ml protein formulation, etc. In each such case, these containers contain sufficient protein to allow delivery of the required 500 mg dose.

As used herein, the phrase "formulated at a dosage capable of delivering the [designated dose] via the [route of administration]" is used to indicate that the pharmaceutical composition can be used to deliver the desired dose of protein via the designated route of administration (e.g., s.c. or i.v.) . As an example, if the required dose for subcutaneous administration is 500 mg, then the clinician can use 2 ml of a protein-based formulation having a concentration of 250 mg/ml, 1 ml of a protein-based formulation having a concentration of 500 mg/ml, 0, 5 ml of a protein-based formulation having a concentration of 1000 mg/ml, etc. In each such case, these protein-based formulations are at a high enough concentration to allow subcutaneous delivery of the protein. Subcutaneous delivery typically requires delivery in volumes of less than about 2 ml, preferably a volume of about 1 ml or less. However, higher volumes can be delivered over a period of time using, for example, a patch/pump mechanism.

Disclosed herein is the use of a protein in the manufacture of a medicament for the treatment of tissue injury in a patient, wherein the medicament is formulated to be placed in containers where each container has sufficient protein to allow delivery of at least about 75 mg, 150 mg, 300 mg or 600 mg of protein per unit dose.

This document discloses the use of a protein for the manufacture of a drug for the treatment of tissue damage in a patient, where the drug is formulated at a dosage that allows systemic delivery (for example, i.v. or s.c. delivery) of 75 mg, 150 mg, 300 mg or 600 mg of protein per unit doses.

18. Example 17: Sets

The present invention also encompasses kits for treating a patient with tissue damage (as the case may be) with a protein. Such kits contain a protein (eg, in liquid or lyophilized form) or a pharmaceutical composition containing a protein (described above). Additionally, such kits may contain means for administering the protein (eg, syringe and vial, pre-filled syringe, pre-filled pen, patch/pump) and instructions for use. The instructions may disclose providing a protein to a patient as part of a particular dosing regimen. Such kits may also contain additional therapeutic agents (described above) for the treatment of psoriasis, for example, to be delivered in combination with a sealed protein.

The phrase "administration means" is used to refer to any available device for the systemic administration of a drug to a patient, including, without limitation, a pre-filled syringe, vial and syringe, pen, auto-injector, dropper, and i. v. injection, pump, patch/pump, etc. With these items, the patient may self-administer the drug (i.e., self-administer the drug), or the drug may be administered by a caregiver or physician.

Disclosed herein are kits for treating a patient with tissue injury, comprising: a) a pharmaceutical composition containing a therapeutically effective amount of a protein; b) means for administering the protein to the patient; and c) instructions for administering the protein subcutaneously to a patient in need thereof.

SEQUENCE TABLE

Amino acid and nucleotide sequences applicable to the practice of the present invention are disclosed in Table 34.

Table 35 . Sequences applicable to the practice of the present invention SEQ ID number sign Subsequence human wild-type CD39 SEQ ID NO: 1 Amino acids MEDTKESNVKTFCSKNILAILGFSSIIAVIALLAVGLTQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHSTYVFLMVLFSLVLFTVAIIGLLIFHKPSYFWKDMV CD39 wild-type rats SEQ ID NO: 2 Amino acids medikdskvkrfcskniliilgfssvlavialiavglthnkplpenvkygivldagsshtnlyiykwpaekendtgvvqlleecqvkgpgiskyaqktdeiaaylaecmkmsteripaskqhqtpvylgatagmrllrmeskqsadevlaavsrslksypfdfqgakiitgqeegaygwitinyllgrftqeqswlnfisdsqkqatfgaldlggsstqvtfvplnqtleapetslqfrlygtdytvythsflcygkdqalwqklaqdiqvssggilkdpcfypgykkvvnvselygtpctkrfekklpfnqfqvqgtgdyeqchqsilkffnnshcpysqcafngvflpplqgsfgafsafyfvmdffkkmandsvssqekmteitknfcskpweevkasyptvkekylseycfsgtyilslllqgynftgtswdqihfmgkikdsnagwtlgymlnltnmipaeqplspplphstyislmvlfslvlvamvitglfifskpsyfwkeav CD39L3 SEQ ID NO: 3 Amino acids QIHKQEVLPPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKVKGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQPKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARSYCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRLPIEP EP28 SEQ ID NO: 4 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 5 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1 SEQ ID NO: 6 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 7 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP2 SEQ ID NO: 8 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvmdvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 9 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgatggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccaaggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP3 SEQ ID NO: 10 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkgfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplrtplshst SEQ ID NO: 11 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagggattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgcgcacacctctgagccacagcacc EP4 SEQ ID NO: 12 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfaqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplrtplshst SEQ ID NO: 13 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgcgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgaggacacctctgagccacagcacc EP5 SEQ ID NO: 14 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvmdvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfidkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 15 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgatggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcgacaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP6 SEQ ID NO: 16 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigisltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvmdvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalrqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 17 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctccctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgatggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgcggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP7 SEQ ID NO: 18 Amino acids tqnkalpenvkygivldagsshtslyiykwpaeeendtgvvhqveecrvkgpgiskfvqkvneigiylsdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldaverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgtgnyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 19 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgaggaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgtccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgcggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcaccggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP8 SEQ ID NO: 20 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldaverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 21 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgattcccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgcggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggtaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtagtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgccattccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP9 SEQ ID NO: 22 Amino acids TQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALRQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHST SEQ ID NO: 23 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgaggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP10 SEQ ID NO: 24 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgtgnyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 25 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctatggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcaccggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcctttgagcacacctctgagccacagcacc EP11 SEQ ID NO: 26 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgtgnyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 27 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcaccggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgactagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP12 SEQ ID NO: 28 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasndilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgtgnyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 29 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgatatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcaccggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP13 SEQ ID NO: 30 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllpqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 31 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgccgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14 SEQ ID NO: 32 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 33 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP15 SEQ ID NO: 34 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvkvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllpqgyhftadswehihfigkiqgsdagwtlgymlnltnmisaeqplstplshst SEQ ID NO: 35 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggcgctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaaggtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccatacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgccgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatctccgccgagcagcccctgagcacacctctgagccacagcacc EP17 SEQ ID NO: 36 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 37 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17.1 SEQ ID NO: 38 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 39 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP18 SEQ ID NO: 40 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneidiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 41 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcgacatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc ep19 SEQ ID NO: 42 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswedihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 43 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggaggacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP20 SEQ ID NO: 44 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasngilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihsigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 45 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgggatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccactccatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP21 SEQ ID NO: 46 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplrtplshst SEQ ID NO: 47 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgcgcacacctctgagccacagcacc EP22 SEQ ID NO: 48 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasngilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplgtplshst SEQ ID NO: 49 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgggatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgcCttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgttgaatctgaccaacatgatccccgccgagcagcccctgggcacacctctgagccacagcacc EP23 SEQ ID NO: 50 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsfmcygkdqalrqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihsigkiqgsdagwtlgymlnltnmipaeqplrtplshst SEQ ID NO: 51 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttatgtgctacggaaaggaccaggctctgaggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgtaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccactccatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagaacacctctgagccacagcacc EP24 SEQ ID NO: 52 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerakeviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehnhfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 53 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccaaggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacaaccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17_K405N SEQ ID NO: 54 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 55 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17 SEQ ID NO: 56 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 57 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28aa1-3 SEQ ID NO: 58 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 59 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggacgccggctcctcccacacctccctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcaccaagtggaagagtgcagagtgaagggccccggcatctccaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccctcggtcccagcaccaggaaacccctgtctacctgggcgccaccgccggcatgcggctgctgcggatggaatccgaggaactggccgaccgggtgctggacgtggtggaacggtccctgtccaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagagggcgcctacggctggatcaccatcaactacctgctgggcaagttctcccagaagaatcaggaaaccttcggcgccctggacctgggcggagccagcacccaagtcacattcgtgccccagaaccagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaacgtgtacacccacagctttctgtgctacggcaaggaccaggccctgtggcagaagctggccaaggacatccaagtggcctccaacgagatcctgcgggacccctgcttccaccccggctacaagaaagtggtcaacgtgtccgacctgtacaagaccccttgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagtccatcctggaactgttcaacacctcctactgcccctactcccagtgcgccttcaacggcatcttcctgcctccactgcagggcgacttcggcgccttctccgccttctacttcgtgatgaagttcctgaacctgacctccgagaaagtgtcccagg aaaaagtgaccgagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgtccgagtactgcttctccggcacctacatcctgtccctgctgctgcagggctaccacttcaccgccgacagctgggagcacatccacttcatcggcaagatccagggatccgacgctggctggaccctgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgtccacccctctgtctcactccacc EP14xEP17 SEQ ID NO: 60 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 61 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP10xEP19_H436D SEQ ID NO: 62 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgtgnyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswedihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 63 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcaccggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggaggacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14xEP19 SEQ ID NO: 64 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 65 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28aa1-15 SEQ ID NO: 66 Amino acids aptssstkktqltsstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 67 DNA gcccctaccagcagcagcaccaagaaaacccagctgaccagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatga agttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17xEP19_H436D SEQ ID NO: 68 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswedihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 69 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggaggacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17xEP19 SEQ ID NO: 70 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 71 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28aa1-16 SEQ ID NO: 72 Amino acids aptssstkktqltssgtqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 73 DNA gcccctacctcctccagcaccaagaaaacccagctgacctccagcggcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggacgccggctcctcccacacctccctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcaccaagtggaagagtgcagagtgaagggccccggcatctccaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccctcggtcccagcaccaggaaacccctgtctacctgggcgccaccgccggcatgcggctgctgcggatggaatccgaggaactggccgaccgggtgctggacgtggtggaacggtccctgtccaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagagggcgcctacggctggatcaccatcaactacctgctgggcaagttctcccagaagaatcaggaaaccttcggcgccctggacctgggcggagccagcacccaagtcacattcgtgccccagaaccagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaacgtgtacacccacagctttctgtgctacggcaaggaccaggccctgtggcagaagctggccaaggacatccaagtggcctccaacgagatcctgcgggacccctgcttccaccccggctacaagaaagtggtcaacgtgtccgacctgtacaagaccccttgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagtccatcctggaactgttcaacacctcctactgcccctactcccagtgcgccttcaacggcatcttcctgcctccactgcagggcgacttcggcgccttctccgccttctacttcgtga tgaagttcctgaacctgacctccgagaaagtgtcccaggaaaaagtgaccgagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgtccgagtactgcttctccggcacctacatcctgtccctgctgctgcagggctaccacttcaccgccgacagctgggagcacatccacttcatcggcaagatccagggatccgacgctggctggaccctgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgtccacccctctgtctcactccacc EP1xEP14xEP19 SEQ ID NO: 74 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 75 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17xEP19 SEQ ID NO: 76 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 77 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttctgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP14 SEQ ID NO: 78 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 79 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28aa1-6 SEQ ID NO: 80 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 81 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28_E174A SEQ ID NO: 82 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeagaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 83 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagccggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP28_E174A_S218A SEQ ID NO: 84 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeagaygwitinyllgkfsqknqetfgaldlggaatqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 85 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagccggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagctgctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_N73Q SEQ ID NO: 86 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekeqdtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 87 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaacaggacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_T229A SEQ ID NO: 88 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqaiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 89 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcaggccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_N292Q SEQ ID NO: 90 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvqvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 91 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgcaggtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_N327Q SEQ ID NO: 92 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfqtsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 93 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttccagaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_N371Q SEQ ID NO: 94 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflqltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 95 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgcagctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14_N457Q SEQ ID NO: 96 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlqltnmipaeqplstplshst SEQ ID NO: 97 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgcagctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc SEQ ID NO: 98 Reverse primer for sense strand with MIL TGCCCTACGAGACAAACAATCAGGAAACCTTCGGCGCCCTGGACCTGGGCGGAGCTTCTACCCAAGTGA CD39(aa39-469) SEQ ID NO: 99 Amino acids qnkalpeNVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLS SEQ ID NO: 100 DNA cagaacaaagccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacc tgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagc CD39(aa46-476) SEQ ID NO: 101 Amino acids NVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHST SEQ ID NO: 102 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgtctcacagcacc CD39(aa46-461) SEQ ID NO: 103 Amino acids NVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNM SEQ ID NO: 104 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaactgactaccggcagcgacgccatcggggg CD39(aa46-461)_dMIL(193-204) SEQ ID NO: 105 Amino acids NVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYCPYSQCAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNM SEQ ID NO: 106 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa46-461)_delta-cys1 SEQ ID NO: 107 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveearvkgpgiskfvqkvneigiyltdamerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 108 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagaggccagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgacgccatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaactgactaccggcagcgacgccatcggggg CD39(aa46-461)_delta-cys2 SEQ ID NO: 109 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpafhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqahqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 110 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggaccctgccttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcaggcccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaactgactaccggcagcgacgccatcggggg CD39(aa46-461)_delta-cys3 SEQ ID NO: 111 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflaygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpatkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 112 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctggcctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagacccccgccaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaactgactaccggcagcgacgccatcggggg CD39(aa46-461)_delta-cys4 SEQ ID NO: 113 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsyapysqaafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 114 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctacgccccctacagccaggccgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaactgactaccggcagcgacgccatcggggg CD39(aa46-461)_delta-cys5 SEQ ID NO: 115 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfaaqpweeiktsyagvkekylseyafsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 116 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttcgccgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtacgccttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggactcacatccacttcatcggcaagattcagggcagcgacgccatcggggg CD39(aa46-461)_dMIL(193-204)_delta-cys1 SEQ ID NO: 117 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveearvkgpgiskfvqkvneigiyltdamerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 118 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagaggccagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgacgccatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa46-461)_dMIL(193-204)_delta-cys2 SEQ ID NO: 119 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpafhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqahqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 120 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggaccctgccttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcaggcccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa46-461)_dMIL(193-204)_delta-cys3 SEQ ID NO: 121 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflaygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpatkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 122 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctggcctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagacccccgccaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa46-461)_dMIL(193-204)_delta-cys4 SEQ ID NO: 123 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsyapysqaafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 124 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctacgccccctacagccaggccgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa46-461)_dMIL(193-204)_delta-cys5 SEQ ID NO: 125 Amino acids nvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfaaqpweeiktsyagvkekylseyafsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnm SEQ ID NO: 126 DNA aacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttcgccg cccagccctgggagaaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtacgccttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctggggagcacatccacttcatcggcaagattcaggggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatg CD39(aa38-476)_delta-337-344 SEQ ID NO: 127 Amino acids TQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHST SEQ ID NO: 128 DNA acacagaacaaagccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagcttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtccc aggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgtctcacagcacc CD39(aa38-476)_C338A_C343A SEQ ID NO: 129 Amino acids TQNKALPENVKYGIVLDAGSSHTSLYIYKWPAEKENDTGVVHQVEECRVKGPGISKFVQKVNEIGIYLTDCMERAREVIPRSQHQETPVYLGATAGMRLLRMESEELADRVLDVVERSLSNYPFDFQGARIITGQEEGAYGWITINYLLGKFSQKTRWFSIVPYETNNQETFGALDLGGASTQVTFVPQNQTIESPDNALQFRLYGKDYNVYTHSFLCYGKDQALWQKLAKDIQVASNEILRDPCFHPGYKKVVNVSDLYKTPCTKRFEMTLPFQQFEIQGIGNYQQCHQSILELFNTSYAPYSQAAFNGIFLPPLQGDFGAFSAFYFVMKFLNLTSEKVSQEKVTEMMKKFCAQPWEEIKTSYAGVKEKYLSEYCFSGTYILSLLLQGYHFTADSWEHIHFIGKIQGSDAGWTLGYMLNLTNMIPAEQPLSTPLSHST SEQ ID NO: 130 DNA acacagaacaaagccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgataccggtgtcgtgcaccaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtacctgggagccacagccggcatgagactgctgcggatggaaagcgaggaactggccgacagagtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggggccagaatcatcaccggccaggaagagggcgcttacggctggatcaccatcaactacctgctgggcaagttcagccagaaaacccggtggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggagccctggacctgggcggagcctctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggccctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctacgccccctacagccaggccgccttcaacggcatcttcctgccacctctgcagggggacttcggcgctttcagcgccttctacttcgtgatgaagttcctga acctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggtacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgtctcacagcacc Expression tag aa1-16 SEQ ID NO: 131 Amino acids aptssstkktqltssg SEQ ID NO: 132 DNA gcccccaccagcagcagcaccaagaagacccagctgaccagcagcggc Expression tag aa1-15 SEQ ID NO: 133 Amino acids aptssstkktqltss SEQ ID NO: 134 DNA gcccctaccagcagcagcaccaagaaaacccagctgaccagcagc Expression tag aa1-6 SEQ ID NO: 135 Amino acids aptsss SEQ ID NO: 136 DNA gcccctaccagcagcagc Expression tag aa1-3 SEQ ID NO: 137 Amino acids apt SEQ ID NO: 138 DNA gcccctacc Expression tag aa1-9 SEQ ID NO: 139 Amino acids aptssstkk SEQ ID NO: 140 DNA gcccctaccagcagcagcaccaagaaa Expression tag aa1-12 SEQ ID NO: 141 Amino acids aptssstkktql SEQ ID NO: 142 DNA gcccctaccagcagcagcaccaagaaaacccagctg Expression tag aa4-12 SEQ ID NO: 143 Amino acids ssstkktql SEQ ID NO: 144 DNA agcagcagcaccaagaaaacccagctg EP28_8M SEQ ID NO: 145 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqdegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygrdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsnfyyvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagqerwlrdycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 146 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggacgagggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggccgggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcaacttctactacgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtga cagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcttacgccggacaggaacggtggctgcgggactactgtttcagcggcacctacatcctgtccctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgtctcacagcacc CD39(aa38-476)_dMIL(193-204)_C-KAPPA SEQ ID NO: 147 Amino acids tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgeggggstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 148 DNA acggtggccgctcccagcgtgttcatcttcccccccagcgacgagcagctgaagagcggcaccgccagcgtggtgtgcctgctgaacaacttctacccccgggaggccaaggtgcagtggaaggtggacaacgccctgcagagcggcaacagccaggaaagcgtcaccgagcaggacagcaaggactccacctacagcctgagcagcaccctgaccctgagcaaggccgactacgagaagcacaaggtgtacgcctgcgaggtgacccaccagggcctgtccagccccgtgaccaagagcttcaaccggggcgagggaggcggaggatctacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtgg ccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc CD39(aa38-476)_dMIL(193-204)_UBI SEQ ID NO: 149 Amino acids mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyniqkestlhlvlrlrggggggstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 150 DNA atgcaaatcttcgtgaagaccctgactggtaagaccatcaccctcgaggtggagcccagtgacaccatcgagaatgtcaaggcaaagatccaagataaggaaggcatccctcctgatcagcagaggttgatctttgctgggaaacagctggaagatggacgcaccctgtctgactacaacatccagaaagagtccactctgcacttggtcctgcgcttgagggggggtggaggcggaggatctacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgca ccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc CD39(aa38-476)_dMIL(193-204)_HSAI HSA-domain I-G4S-CD39-dMIL SEQ ID NO: 151 Amino acids dahksevahrfkdlgeenfkalvliafaqylqqspfedhvklvnevtefaktcvadesaencdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkldelrggggstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 152 DNA gacgcccacaagagcgaggtggcccaccggttcaaggacctgggcgaggaaaacttcaaggccctggtgctgatcgccttcgcccagtacctgcagcagagccccttcgaagatcacgtaaagttagtcaacgaggttacggaattcgcaaagacatgcgttgctgacgaatccgctgagaattgtgacaagagtttgcacactttattcggagataagttgtgtactgtagctactttgagagagacttacggtgaaatggctgactgctgtgcaaaacaggaaccagaacgtaacgaatgtttccttcagcataaggatgataaccctaaccttccaaggcttgttaggccagaagtcgacgtgatgtgcaccgccttccatgataatgaagagacttttcttaaaaagtacctatacgagattgcaaggcgtcatccatatttttacgccccagagctgttgtttttcgcaaagagatacaaagctgcatttactgagtgttgccaagctgccgacaaggccgcttgtttgctaccaaagttggacgaattgagaggaggcggaggatctacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctgga tcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc CD39(aa38-476)_dMIL(193-204)_HSAII SEQ ID NO: 153 Amino acids degkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekccaaadphecyakvfdefkpggggstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 154 DNA gacgagggtaaggcatcatctgccaagcagagattaaaatgtgcatctttgcaaaaatttggagagagagcttttaaggcatgggctgttgcccgactaagccaaagattcccaaaagccgaatttgctgaagtatccaagctggtgactgatttgactaaagtacatacagaatgttgccatggcgaccttttagaatgtgctgatgacagagcagatttggctaagtatatctgcgaaaatcaagattcaatcagctctaagctgaaggaatgttgcgagaaaccactgttagaaaaatcgcattgtattgctgaagttgaaaatgatgagatgcctgctgacttgccttctcttgccgctgattttgttgagtcgaaggatgtctgtaagaattatgctgaagctaaagacgttttcctgggtatgttcttatatgagtacgcaagacgtcacccagattactctgtggttctgctactgagattggctaaaacatacgagacaacgctggagaagtgctgtgctgccgctgaccctcatgagtgctatgcaaaggtttttgatgaattcaaaccaggaggcggaggatctacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccagg aagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14 with MIL SEQ ID NO: 155 Amino acids tqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqktrwfsivpyetnnqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 156 DNA acccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaccagatggttcagcatcgtgccctacgagacaaacaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctga acctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc SEQ ID NO: 157 Direct primer TCGCGATCCTGGAAGGCGTGCACTGCGCCCCTACCAGCAGCAGCACCAAGAAAACCCAGCTGACCAGCAGCACCCAGAACAAGGCCCTGC SEQ ID NO: 158 reverse primer TAGAAGGCACAGTCGAGG SEQ ID NO: 159 Direct primer CtggtcgcgatcctggaaggcgtgcactgcgcccctaccagcagcagcAcccagaacaaggccctg SEQ ID NO: 160 Direct primer CtggtcgcgatcctggaaggcgtgcactgcgcccctaccagcagcagcAcccagaacaaggccctg SEQ ID NO: 161 Direct primer CtggtcgcgatcctggaaggcgtgcactgcgcccctaccAcccagaacaaggccctg SEQ ID NO: 162 Direct primer CtggtcgcgatcctggaaggcgtgcactgcgcccctaccagcagcagcaccaagaaaAcccagaacaaggccctg SEQ ID NO: 163 Direct primer CtggtcgcgatcctggaaggcgtgcactgcgcccctaccagcagcagcaccaagaaaacccagctgAcccagaacaaggccctg SEQ ID NO: 164 Direct primer ctggtcgcgatcctggaaggcgtgcactgcagcagcagcaccaagaaaacccagctgAcccagaacaaggccctg SEQ ID NO: 165 Primer P270 CATACGATTTAGGTGA SEQ ID NO: 166 Primer P271 TAGAAGGCACAGTCGAGG SEQ ID NO: 167 Ubiquitin label Mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyniqkestlhlvlrlrgg SEQ ID NO: 168 C-kappa label Tvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltlskadyekhkvyacevthqglsspvtksfnrge SEQ ID NO: 169 Label representing HSA domain I Dahksevahrfkdlgeenfkalvliafaqylqqspfedhvklvnevtefaktcvadesaencdkslhtlfgdklctvatlretygemadccakqepernecflqhkddnpnlprlvrpevdvmctafhdneetflkkylyeiarrhpyfyapellffakrykaafteccqaadkaacllpkldelr SEQ ID NO: 170 Label representing HSA domain II Degkassakqrlkcaslqkfgerafkawavarlsqrfpkaefaevsklvtdltkvhtecchgdllecaddradlakyicenqdsissklkeccekpllekshciaevendempadlpslaadfveskdvcknyaeakdvflgmflyeyarrhpdysvvlllrlaktyettlekccaaadphecyakvfdefkp SEQ ID NO: 171 Primer P928 CTGCCGAGAAAGAACAGGACACCGGCGTGG SEQ ID NO: 172 Primer P929 CCACGCCGGTGTCCTGTTCTTTCTCGGCAG SEQ ID NO: 173 Primer P930 CGTGCCCCAGAATCAGGCCATCGAGAGCC SEQ ID NO: 174 Primer P931 GGCTCTCGATGGCCTGATTCTGGGGCACG SEQ ID NO: 175 Primer P932 GGCTACAAGAAAGTCGTGCAGGTGTCCCGACCTGTACAAGAC SEQ ID NO: 176 Primer P933 GTCTTGTACAGGTCGGACACCTGCACGACTTTCTTGTAGCC SEQ ID NO: 177 Primer P934 GCATCCTGGAACTGTTCCAGACAGCTACTGCCCC SEQ ID NO: 178 Primer P935 GGGGCAGTAGCTGGTCTGGAACAGTTCCAGGATGC SEQ ID NO: 179 Primer P936 CCGTGATGAAGTTCCTGCAGCTGACCAGCGAGAAG SEQ ID NO: 180 Primer P937 CTTCTCGCTGGTCAGCTGCAGGAACTTCATCACGG SEQ ID NO: 181 Primer P938 CACTGGGCTACATGCTGCAGCTGACCAACATGATCC SEQ ID NO: 182 Primer P939 GGATCATGTTGGTCAGCTGCAGCATGTAGCCCAGTG SEQ ID NO: 183 Primer P878 CTACATCCTGAGCCTGCTGCAGCAGGGCTACCACTTCAC SEQ ID NO: 184 Primer P879 GTGAAGTGGTAGCCCTGCTGCAGCAGGCTCAGGATGTAG SEQ ID NO: 185 Primer P880 GAGAAGTACCTGAGCGAGTTTTGCTTCAGCGGCACCTACATCC SEQ ID NO: 186 Primer P881 GGATGTAGGTGCCGCTGAAGCAAAACTCGCTCAGGTACTTCTC SEQ ID NO: 187 Primer P882 GTTCGAGATCCAGGGCACCGGCAATTACCAGCAGTG SEQ ID NO: 188 Primer P883 CACTGCTGGTAATTGCCGGTGCCCTGGATCTCGAAC SEQ ID NO: 189 Primer P884 CGCCGATAGCTGGGAGCACATCCACTTCATCGGCAAG SEQ ID NO: 190 Primer P885 CTTGCCGATGAAGTGGATGTGCTTCCCAGCTATCGGCG SEQ ID NO: 191 R113M, matrix GAGATCGGCATCTACCTGACCGACTGCATGGAACGGGCCAtGGAAGTGATCCCCAGAAGCCAGCACCAGGAAACCCCCGTGTATCTGGGAGCCACCGCCGGCATGAGACTGCTGAGAATG SEQ ID NO: 192 R113M straight GAGATCGGCATCTACCTGACCGACT SEQ ID NO: 193 R113M reverse CATTCTCAGCAGTCTCAT SEQ ID NO: 194 F330S, matrix CTTCAGCGCCTTCTACTcCGTGATGAAGTTCCTGAACCTGACCAGCGAGAAGGTGTCCCAGGAAAAAGTGACAGAGATGATGAAGAAGTTCTGCGCCCAGCCCTGGGAGGAAATCAAGAC SEQ ID NO: 195 F330S straight CTTCAGCGCCTTCTACTCC SEQ ID NO: 196 F330S reverse GGTCTTGAATTTCCTCCCAG SEQ ID NO: 197 Y377F matrix CTGGGAGGAAATCAAGACCTCCTACGCTGGCGTGAAAGAGAAGTACCTGAGCGAGTtCTGCTTCAGCGGCACCTACATCCTGAGCCTGCTGCTGCAGGGCTACCACTTCACCGCCGATA SEQ ID NO: 198 L389C, matrix CTGGGAGGAAATCAAGACCTCCTACGCTGGCGTGAAAGAGAAGTACCTGAGCGAGTACTGCTTCAGCGGCACCTACATCCTGAGCCTGCTGCaGCAGGGCTACCACTTCACCGCCGATA SEQ ID NO: 199 Y377F/L389Q Matrix CTGGGAGGAAATCAAGACCTCCTACGCTGGCGTGAAAGAGAAGTACCTGAGCGAGTtCTGCTTCAGCGGCACCTACATCCTGAGCCTGCTGCaGCAGGGCTACCACTTCACCGCCGATA SEQ ID NO: 200 Direct primer CTGGGAGGAAATCAAGACC SEQ ID NO: 201 reverse primer TATCGGCGGTGAAGTGGTA SEQ ID NO: 202 Primer for WT CTGGGAGGAAATCAAGACCTCCTACGCTGGCGTGAAAGAGAAGTACCTGAGCGAGTACTGCTTCAGCGGCACCTACATCCTGAGCCTGCTGCTGCAGGGCTACCACTTCACCGCCGATA SEQ ID NO: 203 Direct for Mut174 CACCGGCCAGGAAGCCGGCGCCCTACG SEQ ID NO: 204 Reverse for Mut174 CGTAGGCGCCGGCTTCCTGGCCGGTG SEQ ID NO: 205 Direct for Mut218 GGACCTGGGCGGAGCTGCTACCCAAGTGACCTTC SEQ ID NO: 206 Reverse for Mut218 GAAGGTCACTTGGGTAGCAGCTCCGCCCAGGTCC SEQ ID NO: 207 Direct for protein with MIL CTGGATCACCATCAACTACCTGCTGGGCAAGTTCAGCCAGAAGACCAGATGGTTCAGCATCGTGCCCTACGAGACAAACA SEQ ID NO: 208 Reverse for protein with MIL TCACTTGGGTAGAAGCTCCGCCCAGGTCCAGGGCGCCGAAGGTTTCCTGATTGTTTGTCTCGTAGGGCA EP1aa1-3 SEQ ID NO: 209 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 210 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17aa1-3 SEQ ID NO: 211 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 212 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17aa1-6 SEQ ID NO: 213 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 214 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttctgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17_K405Naa1-15 SEQ ID NO: 215 Amino acids aptssstkktqltsstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 216 DNA gcccctaccagcagcagcaccaagaaaacccagctgaccagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatga agttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17xEP19aa1-3 SEQ ID NO: 217 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 218 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttctgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP17xEP19aa1-6 SEQ ID NO: 219 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 220 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttctgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP14aa1-3 SEQ ID NO: 221 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 222 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP14aa1-6 SEQ ID NO: 223 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 224 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17xEP19aa1-3 SEQ ID NO: 225 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 226 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17xEP19aa1-6 SEQ ID NO: 227 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylsefcfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 228 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP14aa1-3 SEQ ID NO: 229 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 230 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggacgccggctcctcccacacctccctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcaccaagtggaagagtgcagagtgaagggccccggcatctccaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagagaagtgatccctcggtcccagcaccaggaaacccctgtctacctgggcgccaccgccggcatgcggctgctgcggatggaatccgaggaactggccgaccgggtgctggacgtggtggaacggtccctgtccaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagagggcgcctacggctggatcaccatcaactacctgctgggcaagttctcccagaagaatcaggaaaccttcggcgccctggacctgggcggagccagcacccaagtcacattcgtgccccagaaccagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaacgtgtacacccacagctttctgtgctacggcaaggaccaggccctgtggcagaagctggccaaggacatccaagtggcctccaacgagatcctgcgggacccctgcttccaccccggctacaagaaagtggtcaacgtgtccgacctgtacaagaccccttgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaactaccagcagtgccaccagtccatcctggaactgttcaacacctcctactgcccctactcccagtgcgccttcaacggcatcttcctgcctccactgcagggcgacttcggcgccttctccgccttctactccgtgatgaagttcctgaacctgacctccgagaaagtgtcccagg aaaaagtgaccgagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgtccgagtactgcttctccggcacctacatcctgtccctgctgctgcagggctaccacttcaccgccgacagctgggagcacatccacttcatcggcaagatccagggatccgacgctggctggaccctgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgtccacccctctgtctcactccacc EP14aa1-6 SEQ ID NO: 231 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 232 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccttggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggttacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP14xEP19aa1-3 SEQ ID NO: 233 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 234 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP1xEP14xEP19aa1-6 SEQ ID NO: 235 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerameviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafysvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 236 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccatggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctactccgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17aa1-3 SEQ ID NO: 237 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 238 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17aa1-6 SEQ ID NO: 239 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 240 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP17aa1-15 SEQ ID NO: 241 Amino acids aptssstkktqltsstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvnekylsefcfsgtyilslllqgyhftadswehihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 242 DNA gcccctaccagcagcagcaccaagaaaacccagctgaccagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatga agttcctgaacctgaccagcgagaaggtgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccaaccctgggaggaaatcaagacctcctacgctggcgtgaacgagaagtacctgagcgagttttgcttcagcggcacctacatcctgagcctgctgctgcagggctaccacttcaccgccgatagctgggagcacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP19aa1-3 SEQ ID NO: 243 Amino acids apttqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswedihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 244 DNA gcccctaccacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaaggtgtcccagg aaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggaggacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc EP19aa1-6 SEQ ID NO: 245 Amino acids aptssstqnkalpenvkygivldagsshtslyiykwpaekendtgvvhqveecrvkgpgiskfvqkvneigiyltdcmerareviprsqhqetpvylgatagmrllrmeseeladrvldvverslsnypfdfqgariitgqeegaygwitinyllgkfsqknqetfgaldlggastqvtfvpqnqtiespdnalqfrlygkdynvythsflcygkdqalwqklakdiqvasneilrdpcfhpgykkvvnvsdlyktpctkrfemtlpfqqfeiqgignyqqchqsilelfntsycpysqcafngiflpplqgdfgafsafyfvmkflnltsekvsqekvtemmkkfcaqpweeiktsyagvkekylseycfsgtyilsllqqgyhftadswedihfigkiqgsdagwtlgymlnltnmipaeqplstplshst SEQ ID NO: 246 DNA gcccctaccagcagcagcacccagaacaaggccctgcccgagaacgtgaagtacggcatcgtgctggatgccggcagcagccacaccagcctgtacatctacaagtggcctgccgagaaagaaaacgacaccggcgtggtgcatcaggtggaagagtgcagagtgaagggccctggcatcagcaagttcgtgcagaaagtgaacgagatcggcatctacctgaccgactgcatggaacgggccagggaagtgatccccagaagccagcaccaggaaacccccgtgtatctgggagccaccgccggcatgagactgctgagaatggaaagcgaggaactggccgaccgggtgctggacgtggtggaaagaagcctgagcaactacccattcgattttcaaggcgccagaatcatcaccggccaggaagaaggcgcctacggctggatcaccatcaactacctgctgggcaagttcagccagaagaatcaggaaaccttcggcgccctggacctgggcggagcttctacccaagtgaccttcgtgccccagaatcagaccatcgagagccccgacaacgccctgcagttccggctgtacggcaaggactacaatgtgtacacccacagctttctgtgctacggaaaggaccaggctctgtggcagaagctggccaaggacatccaggtggccagcaacgagatcctgcgggacccttgcttccaccccggctacaagaaagtcgtgaacgtgtccgacctgtacaagaccccctgcaccaagagattcgagatgaccctgcccttccagcagttcgagatccagggcatcggcaattaccagcagtgccaccagagcatcctggaactgttcaacaccagctactgcccctacagccagtgcgccttcaacggcatcttcctgccacctctgcagggggatttcggcgccttcagcgccttctacttcgtgatgaagttcctgaacctgaccagcgagaagg tgtcccaggaaaaagtgacagagatgatgaagaagttctgcgcccagccctgggaggaaatcaagacctcctacgctggcgtgaaagagaagtacctgagcgagtactgcttcagcggcacctacatcctgagcctgctgcagcagggctaccacttcaccgccgatagctgggaggacatccacttcatcggcaagattcagggcagcgacgccggctggacactgggctacatgctgaatctgaccaacatgatccccgccgagcagcccctgagcacacctctgagccacagcacc SEQ ID NO: 247 Amino acids EFRHDS SEQ ID NO: 248 DNA GAATTCCGGCACGACAGC SEQ ID NO: 249 Amino acids HHHHH SEQ ID NO: 250 DNA CATCATCATCATCATCAC

--->

SEQUENCE LIST

<110> NOVARTIS AG

<120> SOLUBILIZED APIRASES, METHODS AND USES

<130> PAT057510-EP-EPA

<140> EP 18184269.1

<141> 07/18/2018

<160> 253

<170> PatentIn version 3.5

<210> 1

<211> 510

<212> PROTEIN

<213> Homo sapiens

<400> 1

Met Glu Asp Thr Lys Glu Ser Asn Val Lys Thr Phe Cys Ser Lys Asn

1 5 10 15

Ile Leu Ala Ile Leu Gly Phe Ser Ser Ile Ile Ala Val Ile Ala Leu

20 25 30

Leu Ala Val Gly Leu Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys

35 40 45

Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile

50 55 60

Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln

65 70 75 80

Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln

85 90 95

Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala

100 105 110

Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu

115 120 125

Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu

130 135 140

Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro

145 150 155 160

Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala

165 170 175

Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys

180 185 190

Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr

195 200 205

Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val

210 215 220

Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg

225 230 235 240

Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr

245 250 255

Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val

260 265 270

Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys

275 280 285

Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg

290 295 300

Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly

305 310 315 320

Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser

325 330 335

Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro

340 345 350

Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys

355 360 365

Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu

370 375 380

Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser

385 390 395 400

Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly

405 410 415

Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp

420 425 430

Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala

435 440 445

Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala

450 455 460

Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr Tyr Val Phe Leu

465 470 475 480

Met Val Leu Phe Ser Leu Val Leu Phe Thr Val Ala Ile Ile Gly Leu

485 490 495

Leu Ile Phe His Lys Pro Ser Tyr Phe Trp Lys Asp Met Val

500 505 510

<210> 2

<211> 511

<212> PROTEIN

<213> Rattus norvegicus

<400> 2

Met Glu Asp Ile Lys Asp Ser Lys Val Lys Arg Phe Cys Ser Lys Asn

1 5 10 15

Ile Leu Ile Ile Leu Gly Phe Ser Ser Val Leu Ala Val Ile Ala Leu

20 25 30

Ile Ala Val Gly Leu Thr His Asn Lys Pro Leu Pro Glu Asn Val Lys

35 40 45

Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Asn Leu Tyr Ile

50 55 60

Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val Gln Leu

65 70 75 80

Leu Glu Glu Cys Gln Val Lys Gly Pro Gly Ile Ser Lys Tyr Ala Gln

85 90 95

Lys Thr Asp Glu Ile Ala Ala Tyr Leu Ala Glu Cys Met Lys Met Ser

100 105 110

Thr Glu Arg Ile Pro Ala Ser Lys Gln His Gln Thr Pro Val Tyr Leu

115 120 125

Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Lys Gln Ser

130 135 140

Ala Asp Glu Val Leu Ala Ala Val Ser Arg Ser Leu Lys Ser Tyr Pro

145 150 155 160

Phe Asp Phe Gln Gly Ala Lys Ile Ile Thr Gly Gln Glu Glu Gly Ala

165 170 175

Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Arg Phe Thr Gln Glu

180 185 190

Gln Ser Trp Leu Asn Phe Ile Ser Asp Ser Gln Lys Gln Ala Thr Phe

195 200 205

Gly Ala Leu Asp Leu Gly Gly Ser Ser Thr Gln Val Thr Phe Val Pro

210 215 220

Leu Asn Gln Thr Leu Glu Ala Pro Glu Thr Ser Leu Gln Phe Arg Leu

225 230 235 240

Tyr Gly Thr Asp Tyr Thr Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

245 250 255

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Gln Asp Ile Gln Val Ser

260 265 270

Ser Gly Gly Ile Leu Lys Asp Pro Cys Phe Tyr Pro Gly Tyr Lys Lys

275 280 285

Val Val Asn Val Ser Glu Leu Tyr Gly Thr Pro Cys Thr Lys Arg Phe

290 295 300

Glu Lys Lys Leu Pro Phe Asn Gln Phe Gln Val Gln Gly Thr Gly Asp

305 310 315 320

Tyr Glu Gln Cys His Gln Ser Ile Leu Lys Phe Phe Asn Asn Ser His

325 330 335

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Val Phe Leu Pro Pro Leu

340 345 350

Gln Gly Ser Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Asp Phe

355 360 365

Phe Lys Lys Met Ala Asn Asp Ser Val Ser Ser Gln Glu Lys Met Thr

370 375 380

Glu Ile Thr Lys Asn Phe Cys Ser Lys Pro Trp Glu Glu Val Lys Ala

385 390 395 400

Ser Tyr Pro Thr Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser

405 410 415

Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr Asn Phe Thr Gly

420 425 430

Thr Ser Trp Asp Gln Ile His Phe Met Gly Lys Ile Lys Asp Ser Asn

435 440 445

Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro

450 455 460

Ala Glu Gln Pro Leu Ser Pro Pro Leu Pro His Ser Thr Tyr Ile Ser

465 470 475 480

Leu Met Val Leu Phe Ser Leu Val Leu Val Ala Met Val Ile Thr Gly

485 490 495

Leu Phe Ile Phe Ser Lys Pro Ser Tyr Phe Trp Lys Glu Ala Val

500 505 510

<210> 3

<211> 441

<212> PROTEIN

<213> Homo sapiens

<400> 3

Gln Ile His Lys Gln Glu Val Leu Pro Pro Gly Leu Lys Tyr Gly Ile

1 5 10 15

Val Leu Asp Ala Gly Ser Ser Arg Thr Thr Val Tyr Val Tyr Gln Trp

20 25 30

Pro Ala Glu Lys Glu Asn Asn Thr Gly Val Val Ser Gln Thr Phe Lys

35 40 45

Cys Ser Val Lys Gly Ser Gly Ile Ser Ser Tyr Gly Asn Asn Pro Gln

50 55 60

Asp Val Pro Arg Ala Phe Glu Glu Cys Met Gln Lys Val Lys Gly Gln

65 70 75 80

Val Pro Ser His Leu His Gly Ser Thr Pro Ile His Leu Gly Ala Thr

85 90 95

Ala Gly Met Arg Leu Leu Arg Leu Gln Asn Glu Thr Ala Ala Asn Glu

100 105 110

Val Leu Glu Ser Ile Gln Ser Tyr Phe Lys Ser Gln Pro Phe Asp Phe

115 120 125

Arg Gly Ala Gln Ile Ile Ser Gly Gln Glu Glu Gly Val Tyr Gly Trp

130 135 140

Ile Thr Ala Asn Tyr Leu Met Gly Asn Phe Leu Glu Lys Asn Leu Trp

145 150 155 160

His Met Trp Val His Pro His Gly Val Glu Thr Thr Gly Ala Leu Asp

165 170 175

Leu Gly Gly Ala Ser Thr Gln Ile Ser Phe Val Ala Gly Glu Lys Met

180 185 190

Asp Leu Asn Thr Ser Asp Ile Met Gln Val Ser Leu Tyr Gly Tyr Val

195 200 205

Tyr Thr Leu Tyr Thr His Ser Phe Gln Cys Tyr Gly Arg Asn Glu Ala

210 215 220

Glu Lys Lys Phe Leu Ala Met Leu Leu Gln Asn Ser Pro Thr Lys Asn

225 230 235 240

His Leu Thr Asn Pro Cys Tyr Pro Arg Asp Tyr Ser Ile Ser Phe Thr

245 250 255

Met Gly His Val Phe Asp Ser Leu Cys Thr Val Asp Gln Arg Pro Glu

260 265 270

Ser Tyr Asn Pro Asn Asp Val Ile Thr Phe Glu Gly Thr Gly Asp Pro

275 280 285

Ser Leu Cys Lys Glu Lys Val Ala Ser Ile Phe Asp Phe Lys Ala Cys

290 295 300

His Asp Gln Glu Thr Cys Ser Phe Asp Gly Val Tyr Gln Pro Lys Ile

305 310 315 320

Lys Gly Pro Phe Val Ala Phe Ala Gly Phe Tyr Tyr Thr Ala Ser Ala

325 330 335

Leu Asn Leu Ser Gly Ser Phe Ser Leu Asp Thr Phe Asn Ser Ser Thr

340 345 350

Trp Asn Phe Cys Ser Gln Asn Trp Ser Gln Leu Pro Leu Leu Leu Pro

355 360 365

Lys Phe Asp Glu Val Tyr Ala Arg Ser Tyr Cys Phe Ser Ala Asn Tyr

370 375 380

Ile Tyr His Leu Phe Val Asn Gly Tyr Lys Phe Thr Glu Glu Thr Trp

385 390 395 400

Pro Gln Ile His Phe Glu Lys Glu Val Gly Asn Ser Ser Ile Ala Trp

405 410 415

Ser Leu Gly Tyr Met Leu Ser Leu Thr Asn Gln Ile Pro Ala Glu Ser

420 425 430

Pro Leu Ile Arg Leu Pro Ile Glu Pro

435 440

<210> 4

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 4

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 5

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 5

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 6

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 6

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 7

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 7

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 8

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 8

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Met

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 9

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 9

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgatggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccaaggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 10

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 10

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Gly Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Arg Thr Pro Leu Ser His Ser Thr

420 425

<210> 11

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 11

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agggattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgcgc 1260

acacctctga gccacagcac c 1281

<210> 12

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 12

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Ala Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Arg Thr Pro Leu Ser His Ser Thr

420 425

<210> 13

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 13

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgcgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagg 1260

acacctctga gccacagcac c 1281

<210> 14

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 14

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Met

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Asp Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 15

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 15

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgatggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcgacaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 16

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 16

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Ser Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Met

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Arg Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 17

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 17

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatctc cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgatggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgc ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 18

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 18

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Glu Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Ser Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Ala Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Thr Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 19

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 19

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgagg aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgtccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg cggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcacc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 20

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 20

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Ala Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 21

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 21

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgattccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg cggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggt aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtagtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

ccattccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 22

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 22

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Arg Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 23

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 23

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctga ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 24

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 24

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Thr Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 25

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 25

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta tggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcacc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcctttgagc 1260

acacctctga gccacagcac c 1281

<210> 26

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 26

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Thr Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 27

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 27

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcacc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ctagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 28

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 28

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Asp Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Thr Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 29

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 29

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga tatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcacc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 30

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 30

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Pro Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 31

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 31

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgccgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 32

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 32

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 33

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 33

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccttgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gttacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 34

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 34

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Lys Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Pro Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Ser Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 35

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 35

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggcgctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaagg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgccca tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgccgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatct ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 36

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 36

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Asn Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 37

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 37

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccaac cctgggagga aatcaagacc tcctacgctg gcgtgaacga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 38

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 38

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 39

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 39

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 40

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 40

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Asp Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 41

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 41

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcgacatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 42

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 42

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu Asp Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 43

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 43

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagga catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 44

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 44

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Gly Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Ser Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 45

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 45

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacgg gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccactcc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 46

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 46

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Arg Thr Pro Leu Ser His Ser Thr

420 425

<210> 47

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 47

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgcgc 1260

acacctctga gccacagcac c 1281

<210> 48

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 48

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Gly Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Gly Thr Pro Leu Ser His Ser Thr

420 425

<210> 49

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 49

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacgg gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgtt gaatctgacc aacatgatcc ccgccgagca gcccctgggc 1260

acacctctga gccacagcac c 1281

<210> 50

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 50

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Met Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Arg Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Ser Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Arg Thr Pro Leu Ser His Ser Thr

420 425

<210> 51

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 51

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttatgtgcta cggaaaggac caggctctga ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgtacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccactcc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgaga 1260

acacctctga gccacagcac c 1281

<210> 52

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 52

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Lys Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Asn His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 53

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 53

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaagga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca caaccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 54

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 54

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Asn Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 55

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 55

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccaac cctgggagga aatcaagacc tcctacgctg gcgtgaacga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 56

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 56

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 57

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 57

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 58

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 58

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 59

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 59

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggac 60

gccggctcct cccacacctc cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcaccaagt ggaaagtgc agagtgaagg gccccggcat ctccaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccagagaa 240

gtgatccctc ggtcccagca cggaaacc cctgtctacc tgggcgccac cgccggcatg 300

cggctgctgc ggatggaatc cgaggaactg gccgaccggg tgctggacgt ggtggaacgg 360

tccctgtcca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagag 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttctccca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gccagcaccc aagtcacatt cgtgccccag 540

aaccagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aacgtgtaca cccacagctt tctgtgctac ggcaaggacc aggccctgtg gcagaagctg 660

gccaaggaca tccaagtggc ctccaacgag atcctgcggg acccctgctt ccaccccggc 720

tacaagaaag tggtcaacgt gtccgacctg tacaagaccc cttgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaactacca gcagtgccac 840

cagtccatcc tggaactgtt caacacctcc tactgcccct actcccagtg cgccttcaac 900

ggcatcttcc tgcctccact gcagggcgac ttcggcgcct tctccgcctt ctacttcgtg 960

atgaagttcc tgaacctgac ctccgagaaa gtgtcccagg aaaaagtgac cgagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctgt ccgagtactg cttctccggc acctacatcc tgtccctgct gctgcaggggc 1140

taccacttca ccgccgacag ctgggagcac atccacttca tcggcaagat ccagggatcc 1200

gacgctggct ggaccctggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgtcca cccctctgtc tcactccacc 1290

<210> 60

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 60

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 61

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 61

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccttgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gttacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 62

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 62

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Thr Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu Asp Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 63

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 63

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcacc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagga catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 64

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 64

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 65

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 65

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccttgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gttacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 66

<211> 442

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 66

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser Thr

1 5 10 15

Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp

20 25 30

Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu

35 40 45

Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val

50 55 60

Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly

65 70 75 80

Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg

85 90 95

Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met

100 105 110

Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp

115 120 125

Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala

130 135 140

Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile

145 150 155 160

Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe Gly

165 170 175

Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln

180 185 190

Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr

195 200 205

Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys

210 215 220

Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser

225 230 235 240

Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val

245 250 255

Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu

260 265 270

Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr

275 280 285

Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys

290 295 300

Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln

305 310 315 320

Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu

325 330 335

Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met

340 345 350

Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala

355 360 365

Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr

370 375 380

Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp

385 390 395 400

Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp

405 410 415

Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln

420 425 430

Pro Leu Ser Thr Pro Leu Ser His Ser Thr

435 440

<210> 67

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 67

gcccctacca gcagcagcac caagaaaacc cagctgacca gcagcaccca gaacaaggcc 60

ctgccgaga acgtgaagta cggcatcgtg ctggatgccg gcagcagcca caccagcctg 120

tacatctaca agtggcctgc cgagaaagaa aacgacaccg gcgtggtgca tcaggtggaa 180

gagtgcagag tgaagggccc tggcatcagc aagttcgtgc agaaagtgaa cgagatcggc 240

atctacctga ccgactgcat ggaacgggcc agggaagtga tccccagaag ccagcaccag 300

gaaacccccg tgtatctggg agccaccgcc ggcatgagac tgctgagaat ggaaagcgag 360

gaactggccg accgggtgct ggacgtggtg gaaagaagcc tgagcaacta cccattcgat 420

tttcaaggcg ccagaatcat caccggccag gaagaaggcg cctacggctg gatcaccatc 480

aactacctgc tgggcaagtt cagccagaag aatcaggaaa ccttcggcgc cctggacctg 540

ggcggagctt ctacccaagt gaccttcgtg ccccagaatc agaccatcga gagccccgac 600

aacgccctgc agttccggct gtacggcaag gactacaatg tgtacaccca cagctttctg 660

tgctacggaa aggaccaggc tctgtggcag aagctggcca aggacatcca ggtggccagc 720

aacgagatcc tgcgggaccc ttgcttccac cccggctaca agaaagtcgt gaacgtgtcc 780

gacctgtaca agaccccctg caccaagaga ttcgagatga ccctgccctt ccagcagttc 840

gagatccagg gcatcggcaa ttaccagcag tgccaccaga gcatcctgga actgttcaac 900

accagctact gcccctacag ccagtgcgcc ttcaacggca tcttcctgcc acctctgcag 960

ggggatttcg gcgccttcag cgccttctac ttcgtgatga agttcctgaa cctgaccagc 1020

1080

gaggaaatca agacctccta cgctggcgtg aaagagaagt acctgagcga gtactgcttc 1140

agcggcacct acatcctgag cctgctgctg cagggctacc acttcaccgc cgatagctgg 1200

gagcacatcc acttcatcgg caagattcag ggcagcgacg ccggctggac actgggctac 1260

atgctgaatc tgaccaacat gatccccgcc gagcagcccc tgagcacacc tctgagccac 1320

agcacc 1326

<210> 68

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 68

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu Asp Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 69

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 69

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagga catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 70

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 70

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 71

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 71

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtttt gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 72

<211> 443

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 72

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser Gly

1 5 10 15

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

20 25 30

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

35 40 45

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

50 55 60

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

65 70 75 80

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

85 90 95

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

100 105 110

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

115 120 125

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

130 135 140

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

145 150 155 160

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

165 170 175

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

180 185 190

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

195 200 205

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

210 215 220

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

225 230 235 240

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

245 250 255

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

260 265 270

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

275 280 285

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

290 295 300

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

305 310 315 320

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

325 330 335

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

340 345 350

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

355 360 365

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

370 375 380

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

385 390 395 400

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

405 410 415

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

420 425 430

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

435 440

<210> 73

<211> 1329

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 73

gcccctacct ccctccagcac caagaaaacc cagctgacct ccagcggcac ccagaacaag 60

gccctgcccg agaacgtgaa gtacggcatc gtgctggacg ccggctcctc ccacacctcc 120

ctgtacatct acaagtggcc tgccgagaaa gaaaacgaca ccggcgtggt gcaccaagtg 180

gaagagtgca gagtgaaggg ccccggcatc tccaagttcg tgcagaaagt gaacgagatc 240

ggcatctacc tgaccgactg catggaacgg gccagagaag tgatccctcg gtcccagcac 300

caggaaaccc ctgtctacct gggcgccacc gccggcatgc ggctgctgcg gatggaatcc 360

gaggaactgg ccgaccgggt gctggacgtg gtggaacggt ccctgtccaa ctacccattc 420

gattttcaag gcgccagaat catcaccggc caggaagagg gcgcctacgg ctggatcacc 480

atcaactacc tgctgggcaa gttctcccag aagaatcagg aaaccttcgg cgccctggac 540

ctgggcggag ccagcaccca agtcacattc gtgccccaga accagaccat cgagagcccc 600

660

ctgtgctacg gcaaggacca ggccctgtgg cagaagctgg ccaaggacat ccaagtggcc 720

tccaacgaga tcctgcggga cccctgcttc caccccggct acaagaaagt ggtcaacgtg 780

tccgacctgt acaagacccc ttgcaccaag agattcgaga tgaccctgcc cttccagcag 840

ttcgagatcc agggcatcgg caactaccag cagtgccacc agtccatcct ggaactgttc 900

aacacctcct actgccccta ctcccagtgc gccttcaacg gcatcttcct gcctccactg 960

cagggcgact tcggcgcctt ctccgccttc tacttcgtga tgaagttcct gaacctgacc 1020

tccgagaaag tgtccgga aaaagtgacc

tgggaggaaa tcaagacctc ctacgctggc gtgaaagaga agtacctgtc cgagtactgc 1140

ttctccggca cctacatcct gtccctgctg ctgcaggggct accacttcac cgccgacagc 1200

tgggagcaca tccacttcat cggcaagatc cagggatccg acgctggctg gaccctgggc 1260

tacatgctga atctgaccaa catgatcccc gccgagcagc ccctgtccac ccctctgtct 1320

cactccacc 1329

<210> 74

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 74

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 75

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 75

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 76

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 76

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 77

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 77

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagttct gcttcagcgg cacctacatc ctgagcctgc tgcagcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 78

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 78

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 79

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 79

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccatgga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccttgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gttacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 80

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 80

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 81

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 81

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccagggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagtactgc ttcagcggca cctacatcct gagcctgctg 1140

ctgcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 82

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 82

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Ala Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 83

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 83

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaagc cggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 84

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 84

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Ala Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ala Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 85

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 85

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaagc cggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agctgctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctacttcgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 86

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 86

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Gln Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 87

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 87

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaacagga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 88

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 88

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Ala Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 89

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 89

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcaggcc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 90

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 90

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Gln Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 91

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 91

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgcagg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 92

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 92

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Gln Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 93

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 93

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tccagaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 94

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 94

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Gln Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 95

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 95

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgcagctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gaatctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 96

<211> 427

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 96

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr

355 360 365

Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser

370 375 380

Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly

385 390 395 400

Trp Thr Leu Gly Tyr Met Leu Gln Leu Thr Asn Met Ile Pro Ala Glu

405 410 415

Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 97

<211> 1281

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 97

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggaaaggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaattacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcgcct tctactccgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

tgcgcccagc cctgggagga aatcaagacc tcctacgctg gcgtgaaaga gaagtacctg 1080

agcgagtact gcttcagcgg cacctacatc ctgagcctgc tgctgcaggg ctaccacttc 1140

accgccgata gctgggagca catccacttc atcggcaaga ttcagggcag cgacgccggc 1200

tggacactgg gctacatgct gcagctgacc aacatgatcc ccgccgagca gcccctgagc 1260

acacctctga gccacagcac c 1281

<210> 98

<211> 69

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 98

tgccctacga gacaaaccaat caggaaacct tcggcgccct ggacctgggc ggagcttcta 60

cccaagtga 69

<210> 99

<211> 431

<212> PROTEIN

<213> Homo sapiens

<400> 99

Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp

1 5 10 15

Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu

20 25 30

Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val

35 40 45

Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly

50 55 60

Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg

65 70 75 80

Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met

85 90 95

Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp

100 105 110

Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala

115 120 125

Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile

130 135 140

Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser Ile

145 150 155 160

Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu

165 170 175

Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile

180 185 190

Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr

195 200 205

Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu

210 215 220

Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu

225 230 235 240

Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser

245 250 255

Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro

260 265 270

Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His

275 280 285

Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln

290 295 300

Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly

305 310 315 320

Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser

325 330 335

Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys

340 345 350

Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu

355 360 365

Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu

370 375 380

Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His

385 390 395 400

Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr

405 410 415

Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser

420 425 430

<210> 100

<211> 1293

<212> DNA

<213> Homo sapiens

<400> 100

cagaacaaag ccctgcccga gaacgtgaag tacggcatcg tgctggatgc cggcagcagc 60

cacaccagcc tgtacatcta caagtggcct gccgagaaag aaaacgatac cggtgtcgtg 120

caccaggtgg aagagtgcag agtgaagggc cctggcatca gcaagttcgt gcagaaagtg 180

aacgagatcg gcatctacct gaccgactgc atggaacggg ccagagaagt gatccccaga 240

agccagcacc aggaaacccc cgtgtacctg ggagccacag ccggcatgag actgctgcgg 300

atggaaagcg aggaactggc cgacagagtg ctggacgtgg tggaaagaag cctgagcaac 360

tacccattcg attttcaagg ggccagaatc atcaccggcc aggaagaggg cgcttacggc 420

tggatcacca tcaactacct gctgggcaag ttcagccaga aaacccggtg gttcagcatc 480

gtgccctacg agacaaacaa tcaggaaacc ttcggagccc tggacctggg cggagcctct 540

acccaagtga ccttcgtgcc ccagaatcag accatcgaga gccccgacaa cgccctgcag 600

ttccggctgt acggcaagga ctacaatgtg tacacccaca gctttctgtg ctacggaaag 660

gaccaggccc tgtggcagaa gctggccaag gacatccagg tggccagcaa cgagatcctg 720

cgggaccctt gcttccaccc cggctacaag aaagtcgtga acgtgtccga cctgtacaag 780

accccctgca ccaagagatt cgagatgacc ctgcccttcc agcagttcga gatccaggggc 840

atcggcaact accagcagtg ccaccagagc atcctggaac tgttcaacac cagctactgc 900

ccctacagcc agtgcgcctt caacggcatc ttcctgccac ctctgcaggg ggacttcggc 960

gctttcagcg ccttctactt cgtgatgaag ttcctgaacc tgaccagcga gaaggtgtcc 1020

caggaaaaag tgacagagat gatgaagaag ttctgcgccc agccctggga ggaaatcaag 1080

acctcctacg ctggcgtgaa agagaagtac ctgagcgagt actgcttcag cggtacctac 1140

atcctgagcc tgctgctgca gggctaccac ttcaccgccg atagctggga gcacatccac 1200

ttcatcggca agattcaggg cagcgacgcc ggctggacac tgggctacat gctgaatctg 1260

accaacatga tccccgccga gcagcccctg agc 1293

<210> 101

<211> 431

<212> PROTEIN

<213> Homo sapiens

<400> 101

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 102

<211> 1293

<212> DNA

<213> Homo sapiens

<400> 102

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatgat ccccgccgag 1260

cagcccctga gcacacctct gtctcacagc acc 1293

<210> 103

<211> 416

<212> PROTEIN

<213> Homo sapiens

<400> 103

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 104

<211> 1248

<212> DNA

<213> Homo sapiens

<400> 104

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 105

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 105

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 106

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 106

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 840

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccaggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 107

<211> 416

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 107

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Ala Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Ala Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 108

<211> 1248

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 108

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agaggccaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgacgcca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 109

<211> 416

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 109

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Ala Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Ala His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 110

<211> 1248

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 110

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggaccctgc cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcaggcc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 111

<211> 416

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 111

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Ala Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Ala

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 112

<211> 1248

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 112

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctggcc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga cccccgccac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 113

<211> 416

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 113

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Ala Pro Tyr Ser Gln Ala Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 114

<211> 1248

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 114

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctacgccc cctacagcca ggccgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 115

<211> 416

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 115

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Thr Arg Trp Phe Ser Ile Val Pro Tyr Glu Thr Asn Asn

145 150 155 160

Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val

165 170 175

Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu

180 185 190

Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe

195 200 205

Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp

210 215 220

Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro

225 230 235 240

Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys

245 250 255

Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln

260 265 270

Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe

275 280 285

Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Ala Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Ala

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

<210> 116

<211> 1248

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 116

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aacccggtgg ttcagcatcg tgccctacga gacaaacaat 480

caggaaacct tcggagccct ggacctgggc ggagcctcta cccaagtgac cttcgtgccc 540

cagaatcaga ccatcgagag ccccgacaac gccctgcagt tccggctgta cggcaaggac 600

tacaatgtgt acacccacag ctttctgtgc tacggaaagg accaggccct gtggcagaag 660

ctggccaagg acatccaggt ggccagcaac gagatcctgc gggacccttg cttccacccc 720

ggctacaaga aagtcgtgaa cgtgtccgac ctgtacaaga ccccctgcac caagagattc 780

gagatgaccc tgcccttcca gcagttcgag atccagggca tcggcaacta ccagcagtgc 840

caccagagca tcctggaact gttcaacacc agctactgcc cctacagcca gtgcgccttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tcgccgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta cgccttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatg 1248

<210> 117

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 117

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Ala Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Ala Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 118

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 118

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agaggccaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgacgcca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 840

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccaggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 119

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 119

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Ala Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Ala His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 120

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 120

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc ctgccttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca ggcccaccag agcatcctgg aactgttcaa caccagctac 840

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccaggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 121

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 121

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Ala Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Ala Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 122

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 122

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct ggcctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagacccccg ccaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 840

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccaggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 123

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 123

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Ala Pro Tyr Ser Gln Ala Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 124

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 124

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 840

gccccctaca gccaggccgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccaggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 125

<211> 404

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 125

Asn Val Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser

1 5 10 15

Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val

20 25 30

Val His Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys

35 40 45

Phe Val Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met

50 55 60

Glu Arg Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro

65 70 75 80

Val Tyr Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser

85 90 95

Glu Glu Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser

100 105 110

Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu

115 120 125

Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe

130 135 140

Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala

145 150 155 160

Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro

165 170 175

Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr

180 185 190

Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys

195 200 205

Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro

210 215 220

Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr

225 230 235 240

Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln

245 250 255

Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile

260 265 270

Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe

275 280 285

Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser

290 295 300

Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val

305 310 315 320

Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe Ala Ala Gln Pro

325 330 335

Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu

340 345 350

Ser Glu Tyr Ala Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln

355 360 365

Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly

370 375 380

Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn

385 390 395 400

Leu Thr Asn Met

<210> 126

<211> 1212

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 126

aacgtgaagt acggcatcgt gctggatgcc ggcagcagcc acaccagcct gtacatctac 60

aagtggcctg ccgagaaaga aaacgatacc ggtgtcgtgc accaggtgga agagtgcaga 120

gtgaagggcc ctggcatcag caagttcgtg cagaaagtga acgagatcgg catctacctg 180

accgactgca tggaacgggc cagagaagtg atccccagaa gccagcacca ggaaaccccc 240

gtgtacctgg gagccacagc cggcatgaga ctgctgcgga tggaaagcga ggaactggcc 300

gacagagtgc tggacgtggt ggaaagaagc ctgagcaact acccattcga ttttcaaggg 360

gccagaatca tcaccggcca ggaagaggggc gcttacggct ggatcaccat caactacctg 420

ctgggcaagt tcagccagaa aaatcaggaa accttcggag ccctggacct gggcggagcc 480

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 540

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 600

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 660

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 720

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 780

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 840

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggacttc 900

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 960

tccggaaa aagtgacaga gatgatgaag aagttcgccg cccagccctg ggaggaaatc 1020

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtacgcctt cagcggtacc 1080

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1140

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1200

ctgaccaaca tg 1212

<210> 127

<211> 431

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 127

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser

145 150 155 160

Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp

165 170 175

Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr

180 185 190

Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp

195 200 205

Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala

210 215 220

Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile

225 230 235 240

Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val

245 250 255

Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu

260 265 270

Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys

275 280 285

His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Phe Asn Gly Ile Phe

290 295 300

Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe

305 310 315 320

Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys

325 330 335

Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile

340 345 350

Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys

355 360 365

Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe

370 375 380

Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly

385 390 395 400

Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met

405 410 415

Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 128

<211> 1293

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 128

acacagaaca aagccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga taccggtgtc 120

gtgcaccagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccagaga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtac ctgggagcca cagccggcat gagactgctg 300

cggatggaaa gcgaggaact ggccgacaga gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggggccaga atcatcaccg gccaggaaga gggcgcttac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaaaacccg gtggttcagc 480

atcgtgccct acgagacaaa caatcaggaa accttcggag ccctggacct gggcggagcc 540

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 600

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 660

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 720

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 780

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 840

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagcttc 900

aacggcatct tcctgccacc tctgcagggg gacttcggcg ctttcagcgc cttctacttc 960

gtgatgaagt tcctgaacct gaccagcgag aaggtgtccc aggaaaaagt gacagagatg 1020

atgaagaagt tctgcgccca gccctgggag gaaatcaaga cctcctacgc tggcgtgaaa 1080

gagaagtacc tgagcgagta ctgcttcagc ggtacctaca tcctgagcct gctgctgcag 1140

ggctaccact tcaccgccga tagctgggag cacatccact tcatcggcaa gattcaggggc 1200

agcgacgccg gctggacact gggctacatg ctgaatctga ccaacatgat ccccgccgag 1260

cagcccctga gcacacctct gtctcacagc acc 1293

<210> 129

<211> 439

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 129

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser

145 150 155 160

Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp

165 170 175

Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr

180 185 190

Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp

195 200 205

Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala

210 215 220

Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile

225 230 235 240

Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val

245 250 255

Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu

260 265 270

Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys

275 280 285

His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Ala Pro Tyr Ser

290 295 300

Gln Ala Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe

305 310 315 320

Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn Leu Thr

325 330 335

Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe

340 345 350

Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys

355 360 365

Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser

370 375 380

Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile

385 390 395 400

His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly

405 410 415

Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser

420 425 430

Thr Pro Leu Ser His Ser Thr

435

<210> 130

<211> 1317

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 130

acacagaaca aagccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga taccggtgtc 120

gtgcaccagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccagaga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtac ctgggagcca cagccggcat gagactgctg 300

cggatggaaa gcgaggaact ggccgacaga gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggggccaga atcatcaccg gccaggaaga gggcgcttac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaaaacccg gtggttcagc 480

atcgtgccct acgagacaaa caatcaggaa accttcggag ccctggacct gggcggagcc 540

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 600

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 660

aaggaccagg ccctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 720

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 780

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 840

ggcatcggca actaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 900

gccccctaca gccaggccgc cttcaacggc atcttcctgc cacctctgca gggggacttc 960

ggcgctttca gcgccttcta cttcgtgatg aagttcctga acctgaccag cgagaaggtg 1020

tccggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1080

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggtacc 1140

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1200

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1260

ctgaccaaca tgatccccgc cgagcagccc ctgagcacac ctctgtctca cagcacc 1317

<210> 131

<211> 16

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide

<400> 131

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser Gly

1 5 10 15

<210> 132

<211> 48

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 132

gcccccacca gcagcagcac caagaagacc cagctgacca gcagcggc 48

<210> 133

<211> 15

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide

<400> 133

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser

1 5 10 15

<210> 134

<211> 45

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 134

gcccctacca gcagcagcac caagaaaacc cagctgacca gcagc 45

<210> 135

<211> 6

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 135

Ala Pro Thr Ser Ser Ser

15

<210> 136

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 136

gcccctacca gcagcagc 18

<210> 137

<211> 3

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 137

Ala Pro Thr

1

<210> 138

<211> 9

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 138

gcccctacc 9

<210> 139

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 139

Ala Pro Thr Ser Ser Ser Thr Lys Lys

15

<210> 140

<211> 27

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 140

gcccctacca gcagcagcac caagaaa 27

<210> 141

<211> 12

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 141

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu

1 5 10

<210> 142

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 142

gcccctacca gcagcagcac caagaaaacc cagctg 36

<210> 143

<211> 9

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide

<400> 143

Ser Ser Ser Thr Lys Lys Thr Gln Leu

15

<210> 144

<211> 27

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 144

agcagcagca ccaagaaaac ccagctg 27

<210> 145

<211> 426

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 145

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Asp Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe

145 150 155 160

Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro

165 170 175

Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu

180 185 190

Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly

195 200 205

Arg Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala

210 215 220

Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys

225 230 235 240

Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe

245 250 255

Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn

260 265 270

Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr

275 280 285

Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu

290 295 300

Gln Gly Asp Phe Gly Ala Phe Ser Asn Phe Tyr Tyr Val Met Lys Phe

305 310 315 320

Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met

325 330 335

Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr

340 345 350

Ala Gly Gln Glu Arg Trp Leu Arg Asp Tyr Cys Phe Ser Gly Thr Tyr

355 360 365

Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp

370 375 380

Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp

385 390 395 400

Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln

405 410 415

Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425

<210> 146

<211> 1278

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 146

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccagaga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggacga gggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaatca ggaaaccttc 480

ggcgccctgg acctgggcgg agcttctacc caagtgacct tcgtgcccca gaatcagacc 540

atcgagagcc ccgacaacgc cctgcagttc cggctgtacg gcaaggacta caatgtgtac 600

acccacagct ttctgtgcta cggccgggac caggctctgt ggcagaagct ggccaaggac 660

atccaggtgg ccagcaacga gatcctgcgg gacccttgct tccaccccgg ctacaagaaa 720

gtcgtgaacg tgtccgacct gtacaagacc ccctgcacca agagattcga gatgaccctg 780

cccttccagc agttcgagat ccagggcatc ggcaactacc agcagtgcca ccagagcatc 840

ctggaactgt tcaacaccag ctactgcccc tacagccagt gcgccttcaa cggcatcttc 900

ctgccacctc tgcaggggga tttcggcgcc ttcagcaact tctactacgt gatgaagttc 960

ctgaacctga ccagcgagaa ggtgtcccag gaaaaagtga cagagatgat gaagaagttc 1020

1080

gactactgtt tcagcggcac ctacatcctg tccctgctgc tgcaggggcta ccacttcacc 1140

gccgatagct gggagcacat ccacttcatc ggcaagattc agggcagcga cgccggctgg 1200

acactgggct acatgctgaa tctgaccaac atgatccccg ccgagcagcc cctgagcaca 1260

cctctgtctc acagcacc 1278

<210> 147

<211> 537

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 147

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln

1 5 10 15

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr

20 25 30

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser

35 40 45

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr

50 55 60

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys

65 70 75 80

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro

85 90 95

Val Thr Lys Ser Phe Asn Arg Gly Glu Gly Gly Gly Gly Ser Thr Gln

100 105 110

Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp Ala

115 120 125

Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu Lys

130 135 140

Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val Lys

145 150 155 160

Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly Ile

165 170 175

Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg Ser

180 185 190

Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met Arg

195 200 205

Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp Val

210 215 220

Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala Arg

225 230 235 240

Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile Asn

245 250 255

Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe Gly Ala

260 265 270

Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn

275 280 285

Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly

290 295 300

Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp

305 310 315 320

Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn

325 330 335

Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val

340 345 350

Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met

355 360 365

Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln

370 375 380

Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro

385 390 395 400

Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly

405 410 415

Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu Asn

420 425 430

Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys

435 440 445

Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly

450 455 460

Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile

465 470 475 480

Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu

485 490 495

His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr

500 505 510

Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro

515 520 525

Leu Ser Thr Pro Leu Ser His Ser Thr

530 535

<210> 148

<211> 1611

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 148

acggtggccg ctcccagcgt gttcatcttc ccccccagcg acgagcagct gaagagcggc 60

accgccagcg tggtgtgcct gctgaacaac ttctaccccc gggaggccaa ggtgcagtgg 120

aaggtggaca acgccctgca gagcggcaac agcggaaa gcgtcaccga gcaggacagc 180

aaggactcca cctacagcct gagcagcacc ctgaccctga gcaaggccga ctacgagaag 240

cacaaggtgt acgcctgcga ggtgacccac cagggcctgt ccagccccgt gaccaagagc 300

ttcaaccgggg gcgagggagg cggaggatct acccagaaca aggccctgcc cgagaacgtg 360

aagtacggca tcgtgctgga tgccggcagc agccacacca gcctgtacat ctacaagtgg 420

cctgccgaga aagaaaacga caccggcgtg gtgcatcagg tggaagagtg cagagtgaag 480

ggccctggca tcagcaagtt cgtgcagaaa gtgaacgaga tcggcatcta cctgaccgac 540

tgcatggaac gggccaggga agtgatcccc agaagccagc accaggaaac ccccgtgtat 600

ctgggagcca ccgccggcat gagactgctg agaatggaaa gcgaggaact ggccgaccgg 660

gtgctggacg tggtggaaag aagcctgagc aactacccat tcgattttca aggcgccaga 720

atcatcaccg gccaggaaga aggcgcctac ggctggatca ccatcaacta cctgctgggc 780

aagttcagcc agaagaatca ggaaaccttc ggcgccctgg acctgggcgg agcttctacc 840

caagtgacct tcgtgcccca gaatcagacc atcgagagcc ccgacaacgc cctgcagttc 900

cggctgtacg gcaaggacta caatgtgtac acccacagct ttctgtgcta cggaaaggac 960

caggctctgt ggcagaagct ggccaaggac atccaggtgg ccagcaacga gatcctgcgg 1020

gacccttgct tccaccccgg ctacaagaaa gtcgtgaacg tgtccgacct gtacaagacc 1080

ccctgcacca agagattcga gatgaccctg cccttccagc agttcgagat ccagggcatc 1140

ggcaattacc agcagtgcca ccagagcatc ctggaactgt tcaacaccag ctactgcccc 1200

tacagccagt gcgccttcaa cggcatcttc ctgccacctc tgcaggggga tttcggcgcc 1260

ttcagcgcct tctacttcgt gatgaagttc ctgaacctga ccagcgagaa ggtgtcccag 1320

gaaaaagtga cagagatgat gaagaagttc tgcgcccagc cctgggagga aatcaagacc 1380

tcctacgctg gcgtgaaaga gaagtacctg agcgagtact gcttcagcgg cacctacatc 1440

ctgagcctgc tgctgcaggg ctaccacttc accgccgata gctgggagca catccacttc 1500

atcggcaaga ttcagggcag cgacgccggc tggacactgg gctacatgct gaatctgacc 1560

aacatgatcc ccgccgagca gcccctgagc acacctctga gccacagcac c 1611

<210> 149

<211> 508

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 149

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu

1 5 10 15

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp

20 25 30

Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys

35 40 45

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu

50 55 60

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly Gly Gly Gly Gly

65 70 75 80

Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val

85 90 95

Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro

100 105 110

Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys

115 120 125

Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu

130 135 140

Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile

145 150 155 160

Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala

165 170 175

Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val

180 185 190

Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln

195 200 205

Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile

210 215 220

Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr

225 230 235 240

Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val

245 250 255

Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg

260 265 270

Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr

275 280 285

Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val

290 295 300

Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys

305 310 315 320

Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg

325 330 335

Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly

340 345 350

Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser

355 360 365

Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro

370 375 380

Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys

385 390 395 400

Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu

405 410 415

Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser

420 425 430

Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly

435 440 445

Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp

450 455 460

Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala

465 470 475 480

Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala

485 490 495

Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

500 505

<210> 150

<211> 1524

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 150

atgcaaatct tcgtgaagac cctgactggt aagaccatca ccctcgaggt ggagcccagt 60

gacaccatcg agaatgtcaa ggcaaagatc caagataagg aaggcatccc tcctgatcag 120

cagaggttga tctttgctgg gaaacagctg gaagatggac gcaccctgtc tgactacaac 180

atccagaaag agtccactct gcacttggtc ctgcgcttga gggggggtgg aggcggagga 240

tctacccaga acaaggccct gcccgagaac gtgaagtacg gcatcgtgct ggatgccggc 300

agcagccaca ccagcctgta catctacaag tggcctgccg agaaagaaaa cgacaccggc 360

gtggtgcatc aggtggaaga gtgcagagtg aagggccctg gcatcagcaa gttcgtgcag 420

aaagtgaacg agatcggcat ctacctgacc gactgcatgg aacgggccag ggaagtgatc 480

cccagaagcc agcaccagga aacccccgtg tatctgggag ccaccgccgg catgagactg 540

ctgagaatgg aaagcgagga actggccgac cgggtgctgg acgtggtgga aagaagcctg 600

agcaactacc cattcgattt tcaaggcgcc agaatcatca ccggccagga agaaggcgcc 660

tacggctgga tcaccatcaa ctacctgctg ggcaagttca gccagaagaa tcaggaaacc 720

ttcggcgccc tggacctggg cggagcttct acccaagtga ccttcgtgcc ccagaatcag 780

accatcgaga gccccgacaa cgccctgcag ttccggctgt acggcaagga ctacaatgtg 840

tacacccaca gctttctgtg ctacggaaag gaccaggctc tgtggcagaa gctggccaag 900

gacatccagg tggccagcaa cgagatcctg cgggaccctt gcttccaccc cggctacaag 960

aaagtcgtga acgtgtccga cctgtacaag accccctgca ccaagagatt cgagatgacc 1020

ctgcccttcc agcagttcga gatccagggc atcggcaatt accagcagtg ccaccagagc 1080

atcctggaac tgttcaacac cagctactgc ccctacagcc agtgcgcctt caacggcatc 1140

ttcctgccac ctctgcaggg ggatttcggc gccttcagcg ccttctactt cgtgatgaag 1200

ttcctgaacc tgaccagcga gaaggtgtcc caggaaaaag tgacagagat gatgaagaag 1260

ttctgcgccc agccctggga ggaaatcaag acctcctacg ctggcgtgaa agagaagtac 1320

ctgagcgagt actgcttcag cggcacctac atcctgagcc tgctgctgca gggctaccac 1380

ttcaccgccg atagctggga gcacatccac ttcatcggca agattcaggg cagcgacgcc 1440

ggctggacac tgggctacat gctgaatctg accaacatga tccccgccga gcagcccctg 1500

agcacacctc tgagccacag cacc 1524

<210> 151

<211> 618

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 151

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu

1 5 10 15

Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln

20 25 30

Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu

35 40 45

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys

50 55 60

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu

65 70 75 80

Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro

85 90 95

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu

100 105 110

Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His

115 120 125

Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg

130 135 140

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg

145 150 155 160

Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala

165 170 175

Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Gly Gly Gly Gly Ser Thr

180 185 190

Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp

195 200 205

Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu

210 215 220

Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val

225 230 235 240

Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly

245 250 255

Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg

260 265 270

Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met

275 280 285

Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp

290 295 300

Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala

305 310 315 320

Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile

325 330 335

Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe Gly

340 345 350

Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln

355 360 365

Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr

370 375 380

Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys

385 390 395 400

Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser

405 410 415

Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val

420 425 430

Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu

435 440 445

Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr

450 455 460

Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys

465 470 475 480

Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln

485 490 495

Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu

500 505 510

Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met

515 520 525

Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala

530 535 540

Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr

545 550 555 560

Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp

565 570 575

Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp

580 585 590

Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln

595 600 605

Pro Leu Ser Thr Pro Leu Ser His Ser Thr

610 615

<210> 152

<211> 1854

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 152

gacgcccaca agagcgaggt ggcccaccgg ttcaaggacc tgggcgagga aaacttcaag 60

gccctggtgc tgatcgcctt cgcccagtac ctgcagcaga gccccttcga agatcacgta 120

aagttagtca acgaggttac ggaattcgca aagacatgcg ttgctgacga atccgctgag 180

aattgtgaca agagtttgca cactttattc ggagataagt tgtgtactgt agctactttg 240

agagagactt acggtgaaat ggctgactgc tgtgcaaaac aggaaccaga acgtaacgaa 300

tgtttccttc agcataagga tgataaccct aaccttccaa ggcttgttag gccagaagtc 360

gacgtgatgt gcaccgcctt ccatgataat gaagagactt ttcttaaaaa gtacctatac 420

gagattgcaa ggcgtcatcc atatttttac gccccagagc tgttgttttt cgcaaagaga 480

tacaaagctg catttactga gtgttgccaa gctgccgaca aggccgcttg tttgctacca 540

aagttggacg aattgagagg aggcggagga tctacccaga acaaggccct gcccgagaac 600

gtgaagtacg gcatcgtgct ggatgccggc agcagccaca ccagcctgta catctacaag 660

tggcctgccg agaaagaaaa cgacaccggc gtggtgcatc aggtggaaga gtgcagagtg 720

aagggccctg gcatcagcaa gttcgtgcag aaagtgaacg agatcggcat ctacctgacc 780

gactgcatgg aacgggccag ggaagtgatc cccagaagcc agcaccagga aacccccgtg 840

tatctgggag ccaccgccgg catgagactg ctgagaatgg aaagcgagga actggccgac 900

cgggtgctgg acgtggtgga aagaagcctg agcaactacc cattcgattt tcaaggcgcc 960

agaatcatca ccggccagga agaaggcgcc tacggctgga tcaccatcaa ctacctgctg 1020

ggcaagttca gccagaagaa tcaggaaacc ttcggcgccc tggacctggg cggagcttct 1080

acccaagtga ccttcgtgcc ccagaatcag accatcgaga gccccgacaa cgccctgcag 1140

ttccggctgt acggcaagga ctacaatgtg tacacccaca gctttctgtg ctacggaaag 1200

gaccaggctc tgtggcagaa gctggccaag gacatccagg tggccagcaa cgagatcctg 1260

cgggaccctt gcttccaccc cggctacaag aaagtcgtga acgtgtccga cctgtacaag 1320

accccctgca ccaagagatt cgagatgacc ctgcccttcc agcagttcga gatccaggggc 1380

atcggcaatt accagcagtg ccaccagagc atcctggaac tgttcaacac cagctactgc 1440

ccctacagcc agtgcgcctt caacggcatc ttcctgccac ctctgcaggg ggatttcggc 1500

gccttcagcg ccttctactt cgtgatgaag ttcctgaacc tgaccagcga gaaggtgtcc 1560

caggaaaaag tgacagagat gatgaagaag ttctgcgccc agccctggga ggaaatcaag 1620

acctcctacg ctggcgtgaa agagaagtac ctgagcgagt actgcttcag cggcacctac 1680

atcctgagcc tgctgctgca gggctaccac ttcaccgccg atagctggga gcacatccac 1740

ttcatcggca agattcaggg cagcgacgcc ggctggacac tgggctacat gctgaatctg 1800

accaacatga tccccgccga gcagcccctg agcacacctc tgagccacag cacc 1854

<210> 153

<211> 625

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 153

Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser

1 5 10 15

Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg

20 25 30

Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu

35 40 45

Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu

50 55 60

Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu

65 70 75 80

Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro

85 90 95

Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met

100 105 110

Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp

115 120 125

Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe

130 135 140

Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu

145 150 155 160

Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala

165 170 175

Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys

180 185 190

Pro Gly Gly Gly Gly Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

195 200 205

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

210 215 220

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

225 230 235 240

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

245 250 255

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

260 265 270

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

275 280 285

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

290 295 300

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

305 310 315 320

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

325 330 335

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

340 345 350

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

355 360 365

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

370 375 380

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

385 390 395 400

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

405 410 415

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

420 425 430

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

435 440 445

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

450 455 460

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

465 470 475 480

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

485 490 495

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

500 505 510

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

515 520 525

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

530 535 540

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

545 550 555 560

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

565 570 575

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

580 585 590

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

595 600 605

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

610 615 620

Thr

625

<210> 154

<211> 1875

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 154

gacgagggta aggcatcatc tgccaagcag agattaaaat gtgcatcttt gcaaaaattt 60

ggagagagag cttttaaggc atgggctgtt gcccgactaa gccaaagatt cccaaaagcc 120

gaatttgctg aagtatccaa gctggtgact gatttgacta aagtacatac agaatgttgc 180

catggcgacc ttttagaatg tgctgatgac agagcagatt tggctaagta tatctgcgaa 240

aatcaagatt caatcagctc taagctgaag gaatgttgcg agaaaccact gttagaaaaa 300

tcgcattgta ttgctgaagt tgaaaatgat gagatgcctg ctgacttgcc ttctcttgcc 360

gctgattttg ttgagtcgaa ggatgtctgt aagaattatg ctgaagctaa agacgttttc 420

ctgggtatgt tcttatatga gtacgcaaga cgtcacccag attactctgt ggttctgcta 480

ctgagattgg ctaaaacata cgagacaacg ctggagaagt gctgtgctgc cgctgaccct 540

catgagtgct atgcaaaggt ttttgatgaa ttcaaaccag gaggcgggagg atctacccag 600

aacaaggccc tgcccgagaa cgtgaagtac ggcatcgtgc tggatgccgg cagcagccac 660

accagcctgt acatctacaa gtggcctgcc gagaaagaaa acgacaccgg cgtggtgcat 720

caggtggaag agtgcagagt gaagggccct ggcatcagca agttcgtgca gaaagtgaac 780

gagatcggca tctacctgac cgactgcatg gaacggggcca gggaagtgat ccccagaagc 840

cagcaccagg aaacccccgt gtatctggga gccaccgccg gcatgagact gctgagaatg 900

gaaagcgagg aactggccga ccgggtgctg gacgtggtgg aaagaagcct gagcaactac 960

ccattcgatt ttcaaggcgc cagaatcatc accggccagg aagaaggcgc ctacggctgg 1020

atcaccatca actacctgct gggcaagttc agccagaaga atcaggaaac cttcggcgcc 1080

ctggacctgg gcggagcttc tacccaagtg accttcgtgc cccagaatca gaccatcgag 1140

agccccgaca acgccctgca gttccggctg tacggcaagg actacaatgt gtacacccac 1200

agctttctgt gctacggaaa ggaccaggct ctgtggcaga agctggccaa ggacatccag 1260

gtggccagca acgagatcct gcgggaccct tgcttccacc ccggctacaa gaaagtcgtg 1320

aacgtgtccg acctgtacaa gaccccctgc acccaagagat tcgagatgac cctgcccttc 1380

cagcagttcg agatccaggg catcggcaat taccagcagt gccaccagag catcctggaa 1440

ctgttcaaca ccagctactg cccctacagc cagtgcgcct tcaacggcat cttcctgcca 1500

cctctgcagg gggatttcgg cgccttcagc gccttctact tcgtgatgaa gttcctgaac 1560

ctgaccagcg agaaggtgtc cggaaaaa gtgacagaga tgatgaagaa gttctgcgcc 1620

cagccctggg aggaaatcaa gacctcctac gctggcgtga aagagaagta cctgagcgag 1680

tactgcttca gcggcaccta catcctgagc ctgctgctgc agggctacca cttcaccgcc 1740

gatagctggg agcacatcca cttcatcggc aagattcagg gcagcgacgc cggctggaca 1800

ctgggctaca tgctgaatct gaccaacatg atccccgccg agcagcccct gagcacacct 1860

ctgagccaca gcacc 1875

<210> 155

<211> 439

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 155

Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu

1 5 10 15

Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala

20 25 30

Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg

35 40 45

Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile

50 55 60

Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro

65 70 75 80

Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly

85 90 95

Met Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu

100 105 110

Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly

115 120 125

Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr

130 135 140

Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Thr Arg Trp Phe Ser

145 150 155 160

Ile Val Pro Tyr Glu Thr Asn Asn Gln Glu Thr Phe Gly Ala Leu Asp

165 170 175

Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln Asn Gln Thr

180 185 190

Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp

195 200 205

Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala

210 215 220

Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser Asn Glu Ile

225 230 235 240

Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val Val Asn Val

245 250 255

Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu Met Thr Leu

260 265 270

Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys

275 280 285

His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser

290 295 300

Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe

305 310 315 320

Gly Ala Phe Ser Ala Phe Tyr Ser Val Met Lys Phe Leu Asn Leu Thr

325 330 335

Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met Lys Lys Phe

340 345 350

Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys

355 360 365

Glu Lys Tyr Leu Ser Glu Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser

370 375 380

Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp Glu His Ile

385 390 395 400

His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly

405 410 415

Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln Pro Leu Ser

420 425 430

Thr Pro Leu Ser His Ser Thr

435

<210> 156

<211> 1317

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 156

acccagaaca aggccctgcc cgagaacgtg aagtacggca tcgtgctgga tgccggcagc 60

agccacacca gcctgtacat ctacaagtgg cctgccgaga aagaaaacga caccggcgtg 120

gtgcatcagg tggaagagtg cagagtgaag ggccctggca tcagcaagtt cgtgcagaaa 180

gtgaacgaga tcggcatcta cctgaccgac tgcatggaac gggccaggga agtgatcccc 240

agaagccagc accaggaaac ccccgtgtat ctgggagcca ccgccggcat gagactgctg 300

agaatggaaa gcgaggaact ggccgaccgg gtgctggacg tggtggaaag aagcctgagc 360

aactacccat tcgattttca aggcgccaga atcatcaccg gccaggaaga aggcgcctac 420

ggctggatca ccatcaacta cctgctgggc aagttcagcc agaagaccag atggttcagc 480

atcgtgccct acgagacaaa caatcaggaa accttcggcg ccctggacct gggcggagct 540

tctacccaag tgaccttcgt gccccagaat cagaccatcg agagccccga caacgccctg 600

cagttccggc tgtacggcaa ggactacaat gtgtacaccc acagctttct gtgctacgga 660

aaggaccagg ctctgtggca gaagctggcc aaggacatcc aggtggccag caacgagatc 720

ctgcgggacc cttgcttcca ccccggctac aagaaagtcg tgaacgtgtc cgacctgtac 780

aagaccccct gcaccaagag attcgagatg accctgccct tccagcagtt cgagatccag 840

ggcatcggca attaccagca gtgccaccag agcatcctgg aactgttcaa caccagctac 900

tgcccctaca gccagtgcgc cttcaacggc atcttcctgc cacctctgca gggggatttc 960

ggcgccttca gcgccttcta ctccgtgatg aagttcctga acctgaccag cgagaaggtg 1020

tccggaaa aagtgacaga gatgatgaag aagttctgcg cccagccctg ggaggaaatc 1080

aagacctcct acgctggcgt gaaagagaag tacctgagcg agtactgctt cagcggcacc 1140

tacatcctga gcctgctgct gcagggctac cacttcaccg ccgatagctg ggagcacatc 1200

cacttcatcg gcaagattca gggcagcgac gccggctgga cactgggcta catgctgaat 1260

ctgaccaaca tgatccccgc cgagcagccc ctgagcacac ctctgagcca cagcacc 1317

<210> 157

<211> 90

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 157

tcgcgatcct ggaaggcgtg cactgcgccc ctaccagcag cagcaccaag aaaacccagc 60

tgaccagcag cacccagaac aaggccctgc 90

<210> 158

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 158

tagaaggcac agtcgagg 18

<210> 159

<211> 66

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 159

ctggtcgcga tcctggaagg cgtgcactgc gcccctacca gcagcagcac ccagaacaag 60

gccctg 66

<210> 160

<211> 66

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 160

ctggtcgcga tcctggaagg cgtgcactgc gcccctacca gcagcagcac ccagaacaag 60

gccctg 66

<210> 161

<211> 57

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 161

ctggtcgcga tcctggaagg cgtgcactgc gcccctacca cccagaacaa ggccctg 57

<210> 162

<211> 75

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 162

ctggtcgcga tcctggaagg cgtgcactgc gcccctacca gcagcagcac caagaaaacc 60

cagaacaagg ccctg 75

<210> 163

<211> 84

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 163

ctggtcgcga tcctggaagg cgtgcactgc gcccctacca gcagcagcac caagaaaacc 60

cagctgaccc agaacaaggc cctg 84

<210> 164

<211> 75

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 164

ctggtcgcga tcctggaagg cgtgcactgc agcagcagca ccaagaaaac ccagctgacc 60

cagaacaagg ccctg 75

<210> 165

<211> 16

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 165

catacgatt aggtga 16

<210> 166

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 166

tagaaggcac agtcgagg 18

<210> 167

<211> 76

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 167

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu

1 5 10 15

Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp

20 25 30

Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys

35 40 45

Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu

50 55 60

Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly

65 70 75

<210> 168

<211> 105

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 168

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln

1 5 10 15

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr

20 25 30

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser

35 40 45

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr

50 55 60

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys

65 70 75 80

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro

85 90 95

Val Thr Lys Ser Phe Asn Arg Gly Glu

100 105

<210> 169

<211> 186

<212> PROTEIN

<213> Homo sapiens

<400> 169

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu

1 5 10 15

Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln

20 25 30

Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu

35 40 45

Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys

50 55 60

Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu

65 70 75 80

Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro

85 90 95

Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu

100 105 110

Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His

115 120 125

Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg

130 135 140

Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg

145 150 155 160

Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala

165 170 175

Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg

180 185

<210> 170

<211> 193

<212> PROTEIN

<213> Homo sapiens

<400> 170

Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser

1 5 10 15

Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg

20 25 30

Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu

35 40 45

Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu

50 55 60

Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu

65 70 75 80

Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro

85 90 95

Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met

100 105 110

Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp

115 120 125

Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe

130 135 140

Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu

145 150 155 160

Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala

165 170 175

Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys

180 185 190

Pro

<210> 171

<211> 30

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 171

ctgccgagaa agaacaggac accggcgtgg 30

<210> 172

<211> 30

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 172

ccacgccggt gtcctgttct ttctcggcag 30

<210> 173

<211> 29

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 173

cgtgccccag aatcaggcca tcgagagcc 29

<210> 174

<211> 29

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 174

ggctctcgat ggcctgattc tggggcacg 29

<210> 175

<211> 41

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 175

ggctacaaga aagtcgtgca ggtgtccgac ctgtacaaga c 41

<210> 176

<211> 41

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 176

gtcttgtaca ggtcggacac ctgcacgact ttcttgtagc c 41

<210> 177

<211> 35

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 177

gcatcctgga actgttccag accagctact gcccc 35

<210> 178

<211> 35

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 178

ggggcagtag ctggtctgga acagttccag gatgc 35

<210> 179

<211> 35

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 179

ccgtgatgaa gttcctgcag ctgaccagcg agaag 35

<210> 180

<211> 35

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 180

cttctcgctg gtcagctgca ggaacttcat cacgg 35

<210> 181

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 181

cactgggcta catgctgcag ctgaccaaca tgatcc 36

<210> 182

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 182

ggatcatgtt ggtcagctgc agcatgtagc ccagtg 36

<210> 183

<211> 39

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 183

ctacatcctg agcctgctgc agcagggcta ccacttcac 39

<210> 184

<211> 39

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 184

gtgaagtggt agccctgctg cagcaggctc aggatgtag 39

<210> 185

<211> 43

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 185

gagaagtacc tgagcgagtt ttgcttcagc ggcacctaca tcc 43

<210> 186

<211> 43

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 186

ggatgtaggt gccgctgaag caaaactcgc tcaggtactt ctc 43

<210> 187

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 187

gttcgagatc cagggcaccg gcaattacca gcagtg 36

<210> 188

<211> 36

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 188

cactgctggt aattgccggt gccctggatc tcgaac 36

<210> 189

<211> 37

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 189

cgccgatagc tgggagcaca tccacttcat cggcaag 37

<210> 190

<211> 37

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 190

cttgccgatg aagtggatgt gctcccagct atcggcg 37

<210> 191

<211> 120

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 191

gagatcggca tctacctgac cgactgcatg gaacgggcca tggaagtgat ccccagaagc 60

cagcaccagg aaacccccgt gtatctggga gccaccgccg gcatgagact gctgagaatg 120

<210> 192

<211> 25

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 192

gagatcggca tctacctgac cgact 25

<210> 193

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 193

cattctcagc agtctcat 18

<210> 194

<211> 120

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 194

cttcagcgcc ttctactccg tgatgaagtt cctgaacctg accagcgaga aggtgtccca 60

ggaaaaagtg acagagatga tgaagaagtt ctgcgcccag ccctgggagg aaatcaagac 120

<210> 195

<211> 19

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 195

cttcagcgcc ttctactcc 19

<210> 196

<211> 19

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 196

ggtcttgatt tcctcccag 19

<210> 197

<211> 119

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 197

ctgggaggaa atcaagacct cctacgctgg cgtgaaagag aagtacctga gcgagttctg 60

cttcagcggc acctacatcc tgagcctgct gctgcaggggc taccacttca ccgccgata 119

<210> 198

<211> 119

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 198

ctgggaggaa atcaagacct cctacgctgg cgtgaaagag aagtacctga gcgagtactg 60

cttcagcggc acctacatcc tgagcctgct gcagcagggc taccacttca ccgccgata 119

<210> 199

<211> 119

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 199

ctgggaggaa atcaagacct cctacgctgg cgtgaaagag aagtacctga gcgagttctg 60

cttcagcggc acctacatcc tgagcctgct gcagcagggc taccacttca ccgccgata 119

<210> 200

<211> 19

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 200

ctgggaggaa atcaagacc 19

<210> 201

<211> 19

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 201

tatcggcggt gaagtggta 19

<210> 202

<211> 119

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 202

ctgggaggaa atcaagacct cctacgctgg cgtgaaagag aagtacctga gcgagtactg 60

cttcagcggc acctacatcc tgagcctgct gctgcaggggc taccacttca ccgccgata 119

<210> 203

<211> 26

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 203

caccggccag gaagccggcg cctacg 26

<210> 204

<211> 26

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 204

cgtaggcgcc ggcttcctgg ccggtg 26

<210> 205

<211> 34

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 205

ggacctgggc ggagctgcta cccaagtgac cttc 34

<210> 206

<211> 34

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 206

gaaggtcact tgggtagcag ctccgcccag gtcc 34

<210> 207

<211> 80

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 207

ctggatcacc atcaactacc tgctgggcaa gttcagccag aagaccagat ggttcagcat 60

cgtgccctac gagacaaaca 80

<210> 208

<211> 69

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic primer"

<400> 208

tcacttgggt agaagctccg cccaggtcca gggcgccgaa ggtttcctga ttgtttgtct 60

cgtagggca 69

<210> 209

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 209

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 210

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 210

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccatggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagtactg cttcagcggc acctacatcc tgagcctgct gctgcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 211

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 211

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 212

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 212

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccatggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagttttg cttcagcggc acctacatcc tgagcctgct gctgcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 213

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 213

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Met Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Phe Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 214

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 214

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccatggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagttctgc ttcagcggca cctacatcct gagcctgctg 1140

ctgcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 215

<211> 442

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 215

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser Thr

1 5 10 15

Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp

20 25 30

Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu

35 40 45

Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val

50 55 60

Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly

65 70 75 80

Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu Val Ile Pro Arg

85 90 95

Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met

100 105 110

Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp

115 120 125

Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala

130 135 140

Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile

145 150 155 160

Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe Gly

165 170 175

Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln

180 185 190

Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr

195 200 205

Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys

210 215 220

Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser

225 230 235 240

Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val

245 250 255

Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu

260 265 270

Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr

275 280 285

Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys

290 295 300

Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln

305 310 315 320

Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu

325 330 335

Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met

340 345 350

Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala

355 360 365

Gly Val Asn Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr Tyr

370 375 380

Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp

385 390 395 400

Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp

405 410 415

Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln

420 425 430

Pro Leu Ser Thr Pro Leu Ser His Ser Thr

435 440

<210> 216

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 216

gcccctacca gcagcagcac caagaaaacc cagctgacca gcagcaccca gaacaaggcc 60

ctgccgaga acgtgaagta cggcatcgtg ctggatgccg gcagcagcca caccagcctg 120

tacatctaca agtggcctgc cgagaaagaa aacgacaccg gcgtggtgca tcaggtggaa 180

gagtgcagag tgaagggccc tggcatcagc aagttcgtgc agaaagtgaa cgagatcggc 240

atctacctga ccgactgcat ggaacggggcc atggaagtga tccccagaag ccagcaccag 300

gaaacccccg tgtatctggg agccaccgcc ggcatgagac tgctgagaat ggaaagcgag 360

gaactggccg accgggtgct ggacgtggtg gaaagaagcc tgagcaacta cccattcgat 420

tttcaaggcg ccagaatcat caccggccag gaagaaggcg cctacggctg gatcaccatc 480

aactacctgc tgggcaagtt cagccagaag aatcaggaaa ccttcggcgc cctggacctg 540

ggcggagctt ctacccaagt gaccttcgtg ccccagaatc agaccatcga gagccccgac 600

aacgccctgc agttccggct gtacggcaag gactacaatg tgtacaccca cagctttctg 660

tgctacggaa aggaccaggc tctgtggcag aagctggcca aggacatcca ggtggccagc 720

aacgagatcc tgcgggaccc ttgcttccac cccggctaca agaaagtcgt gaacgtgtcc 780

gacctgtaca agaccccctg caccaagaga ttcgagatga ccctgccctt ccagcagttc 840

gagatccagg gcatcggcaa ttaccagcag tgccaccaga gcatcctgga actgttcaac 900

accagctact gcccctacag ccagtgcgcc ttcaacggca tcttcctgcc acctctgcag 960

ggggatttcg gcgccttcag cgccttctac ttcgtgatga agttcctgaa cctgaccagc 1020

1080

gaggaaatca agacctccta cgctggcgtg aacgagaagt acctgagcga gttttgcttc 1140

agcggcacct acatcctgag cctgctgctg cagggctacc acttcaccgc cgatagctgg 1200

gagcacatcc acttcatcgg caagattcag ggcagcgacg ccggctggac actgggctac 1260

atgctgaatc tgaccaacat gatccccgcc gagcagcccc tgagcacacc tctgagccac 1320

agcacc 1326

<210> 217

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 217

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 218

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 218

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccatggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagttctg cttcagcggc acctacatcc tgagcctgct gcagcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 219

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 219

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Met Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Phe Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 220

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 220

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccatggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagttctgc ttcagcggca cctacatcct gagcctgctg 1140

cagcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 221

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 221

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 222

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 222

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccatggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccttgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctactccgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagtactg cttcagcggc acctacatcc tgagcctgct gctgcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactgggg ttacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 223

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 223

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Met Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Ser Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 224

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 224

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccatggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccttggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tactccgtga tgaagttcct gaacctgacc agcgagaagg tgtccgga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagtactgc ttcagcggca cctacatcct gagcctgctg 1140

ctgcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggt tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 225

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 225

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Phe Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 226

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 226

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccagggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagttttg cttcagcggc acctacatcc tgagcctgct gcagcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 227

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 227

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Phe Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 228

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 228

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccagggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagttttgc ttcagcggca cctacatcct gagcctgctg 1140

cagcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 229

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 229

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 230

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 230

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggac 60

gccggctcct cccacacctc cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcaccaagt ggaaagtgc agagtgaagg gccccggcat ctccaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccagagaa 240

gtgatccctc ggtcccagca cggaaacc cctgtctacc tgggcgccac cgccggcatg 300

cggctgctgc ggatggaatc cgaggaactg gccgaccggg tgctggacgt ggtggaacgg 360

tccctgtcca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagag 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttctccca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gccagcaccc aagtcacatt cgtgccccag 540

aaccagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aacgtgtaca cccacagctt tctgtgctac ggcaaggacc aggccctgtg gcagaagctg 660

gccaaggaca tccaagtggc ctccaacgag atcctgcggg acccctgctt ccaccccggc 720

tacaagaaag tggtcaacgt gtccgacctg tacaagaccc cttgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaactacca gcagtgccac 840

cagtccatcc tggaactgtt caacacctcc tactgcccct actcccagtg cgccttcaac 900

ggcatcttcc tgcctccact gcagggcgac ttcggcgcct tctccgcctt ctactccgtg 960

atgaagttcc tgaacctgac ctccgagaaa gtgtcccagg aaaaagtgac cgagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctgt ccgagtactg cttctccggc acctacatcc tgtccctgct gctgcaggggc 1140

taccacttca ccgccgacag ctgggagcac atccacttca tcggcaagat ccagggatcc 1200

gacgctggct ggaccctggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgtcca cccctctgtc tcactccacc 1290

<210> 231

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 231

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Ser Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 232

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 232

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccagggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccttggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tactccgtga tgaagttcct gaacctgacc agcgagaagg tgtccgga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagtactgc ttcagcggca cctacatcct gagcctgctg 1140

ctgcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggt tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 233

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 233

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Met Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Ser Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 234

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 234

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccatggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctactccgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagtactg cttcagcggc acctacatcc tgagcctgct gcagcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 235

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 235

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Met Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Ser Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 236

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 236

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccatggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tactccgtga tgaagttcct gaacctgacc agcgagaagg tgtccgga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagtactgc ttcagcggca cctacatcct gagcctgctg 1140

cagcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 237

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 237

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Asn Glu Lys Tyr Leu Ser Glu Phe Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 238

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 238

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccagggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccaacc ctgggaggaa atcaagacct cctacgctgg cgtgaacgag 1080

aagtacctga gcgagttttg cttcagcggc acctacatcc tgagcctgct gctgcaggggc 1140

taccacttca ccgccgatag ctgggagcac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 239

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 239

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Asn Glu Lys Tyr Leu Ser Glu

355 360 365

Phe Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Leu Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu His Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 240

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 240

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccagggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccaaccc tgggaggaaa tcaagacctc ctacgctggc 1080

1140

ctgcagggct accacttcac cgccgatagc tgggagcaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 241

<211> 442

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 241

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Thr Ser Ser Thr

1 5 10 15

Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly Ile Val Leu Asp

20 25 30

Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys Trp Pro Ala Glu

35 40 45

Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu Glu Cys Arg Val

50 55 60

Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val Asn Glu Ile Gly

65 70 75 80

Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu Val Ile Pro Arg

85 90 95

Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala Thr Ala Gly Met

100 105 110

Arg Leu Leu Arg Met Glu Ser Glu Glu Leu Ala Asp Arg Val Leu Asp

115 120 125

Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp Phe Gln Gly Ala

130 135 140

Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly Trp Ile Thr Ile

145 150 155 160

Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln Glu Thr Phe Gly

165 170 175

Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr Phe Val Pro Gln

180 185 190

Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln Phe Arg Leu Tyr

195 200 205

Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu Cys Tyr Gly Lys

210 215 220

Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile Gln Val Ala Ser

225 230 235 240

Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly Tyr Lys Lys Val

245 250 255

Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr Lys Arg Phe Glu

260 265 270

Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly Ile Gly Asn Tyr

275 280 285

Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn Thr Ser Tyr Cys

290 295 300

Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu Pro Pro Leu Gln

305 310 315 320

Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val Met Lys Phe Leu

325 330 335

Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val Thr Glu Met Met

340 345 350

Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys Thr Ser Tyr Ala

355 360 365

Gly Val Asn Glu Lys Tyr Leu Ser Glu Phe Cys Phe Ser Gly Thr Tyr

370 375 380

Ile Leu Ser Leu Leu Leu Gln Gly Tyr His Phe Thr Ala Asp Ser Trp

385 390 395 400

Glu His Ile His Phe Ile Gly Lys Ile Gln Gly Ser Asp Ala Gly Trp

405 410 415

Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile Pro Ala Glu Gln

420 425 430

Pro Leu Ser Thr Pro Leu Ser His Ser Thr

435 440

<210> 242

<211> 1326

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 242

gcccctacca gcagcagcac caagaaaacc cagctgacca gcagcaccca gaacaaggcc 60

ctgccgaga acgtgaagta cggcatcgtg ctggatgccg gcagcagcca caccagcctg 120

tacatctaca agtggcctgc cgagaaagaa aacgacaccg gcgtggtgca tcaggtggaa 180

gagtgcagag tgaagggccc tggcatcagc aagttcgtgc agaaagtgaa cgagatcggc 240

atctacctga ccgactgcat ggaacgggcc agggaagtga tccccagaag ccagcaccag 300

gaaacccccg tgtatctggg agccaccgcc ggcatgagac tgctgagaat ggaaagcgag 360

gaactggccg accgggtgct ggacgtggtg gaaagaagcc tgagcaacta cccattcgat 420

tttcaaggcg ccagaatcat caccggccag gaagaaggcg cctacggctg gatcaccatc 480

aactacctgc tgggcaagtt cagccagaag aatcaggaaa ccttcggcgc cctggacctg 540

ggcggagctt ctacccaagt gaccttcgtg ccccagaatc agaccatcga gagccccgac 600

aacgccctgc agttccggct gtacggcaag gactacaatg tgtacaccca cagctttctg 660

tgctacggaa aggaccaggc tctgtggcag aagctggcca aggacatcca ggtggccagc 720

aacgagatcc tgcgggaccc ttgcttccac cccggctaca agaaagtcgt gaacgtgtcc 780

gacctgtaca agaccccctg caccaagaga ttcgagatga ccctgccctt ccagcagttc 840

gagatccagg gcatcggcaa ttaccagcag tgccaccaga gcatcctgga actgttcaac 900

accagctact gcccctacag ccagtgcgcc ttcaacggca tcttcctgcc acctctgcag 960

ggggatttcg gcgccttcag cgccttctac ttcgtgatga agttcctgaa cctgaccagc 1020

1080

gaggaaatca agacctccta cgctggcgtg aacgagaagt acctgagcga gttttgcttc 1140

agcggcacct acatcctgag cctgctgctg cagggctacc acttcaccgc cgatagctgg 1200

gagcacatcc acttcatcgg caagattcag ggcagcgacg ccggctggac actgggctac 1260

atgctgaatc tgaccaacat gatccccgcc gagcagcccc tgagcacacc tctgagccac 1320

agcacc 1326

<210> 243

<211> 430

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 243

Ala Pro Thr Thr Gln Asn Lys Ala Leu Pro Glu Asn Val Lys Tyr Gly

1 5 10 15

Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr Ile Tyr Lys

20 25 30

Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His Gln Val Glu

35 40 45

Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val Gln Lys Val

50 55 60

Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg Ala Arg Glu

65 70 75 80

Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr Leu Gly Ala

85 90 95

Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu Glu Leu Ala Asp

100 105 110

Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr Pro Phe Asp

115 120 125

Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly Ala Tyr Gly

130 135 140

Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln Lys Asn Gln

145 150 155 160

Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr Gln Val Thr

165 170 175

Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn Ala Leu Gln

180 185 190

Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His Ser Phe Leu

195 200 205

Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala Lys Asp Ile

210 215 220

Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe His Pro Gly

225 230 235 240

Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr Pro Cys Thr

245 250 255

Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu Ile Gln Gly

260 265 270

Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu Leu Phe Asn

275 280 285

Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly Ile Phe Leu

290 295 300

Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe Tyr Phe Val

305 310 315 320

Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln Glu Lys Val

325 330 335

Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu Glu Ile Lys

340 345 350

Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu Tyr Cys Phe

355 360 365

Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr His Phe Thr

370 375 380

Ala Asp Ser Trp Glu Asp Ile His Phe Ile Gly Lys Ile Gln Gly Ser

385 390 395 400

Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr Asn Met Ile

405 410 415

Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser Thr

420 425 430

<210> 244

<211> 1290

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 244

gcccctacca cccagaacaa ggccctgccc gagaacgtga agtacggcat cgtgctggat 60

gccggcagca gccacaccag cctgtacatc tacaagtggc ctgccgagaa agaaaacgac 120

accggcgtgg tgcatcaggt ggaaagtgc agagtgaagg gccctggcat cagcaagttc 180

gtgcagaaag tgaacgagat cggcatctac ctgaccgact gcatggaacg ggccagggaa 240

gtgatcccca gaagccagca cggaaacc cccgtgtatc tgggagccac cgccggcatg 300

agactgctga gaatggaaag cgaggaactg gccgaccggg tgctggacgt ggtggaaaga 360

agcctgagca actacccatt cgattttcaa ggcgccagaa tcatcaccgg cggaagaa 420

ggcgcctacg gctggatcac catcaactac ctgctgggca agttcagcca gaagaatcag 480

gaaaccttcg gcgccctgga cctgggcgga gcttctaccc aagtgacctt cgtgccccag 540

aatcagacca tcgagagccc cgacaacgcc ctgcagttcc ggctgtacgg caaggactac 600

aatgtgtaca cccacagctt tctgtgctac ggaaaggacc aggctctgtg gcagaagctg 660

gccaaggaca tccaggtggc cagcaacgag atcctgcggg acccttgctt ccaccccggc 720

tacaagaaag tcgtgaacgt gtccgacctg tacaagaccc cctgcaccaa gagattcgag 780

atgaccctgc ccttccagca gttcgagatc cagggcatcg gcaattacca gcagtgccac 840

cagagcatcc tggaactgtt caacaccagc tactgcccct acagccagtg cgccttcaac 900

ggcatcttcc tgccacctct gcagggggat ttcggcgcct tcagcgcctt ctacttcgtg 960

atgaagttcc tgaacctgac cagcgagaag gtgtcccagg aaaaagtgac agagatgatg 1020

aagaagttct gcgcccagcc ctgggaggaa atcaagacct cctacgctgg cgtgaaagag 1080

aagtacctga gcgagtactg cttcagcggc acctacatcc tgagcctgct gcagcaggggc 1140

taccacttca ccgccgatag ctgggaggac atccacttca tcggcaagat tcagggcagc 1200

gacgccggct ggacactggg ctacatgctg aatctgacca acatgatccc cgccgagcag 1260

cccctgagca cacctctgag cccagcacc 1290

<210> 245

<211> 433

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polypeptide

<400> 245

Ala Pro Thr Ser Ser Ser Thr Gln Asn Lys Ala Leu Pro Glu Asn Val

1 5 10 15

Lys Tyr Gly Ile Val Leu Asp Ala Gly Ser Ser His Thr Ser Leu Tyr

20 25 30

Ile Tyr Lys Trp Pro Ala Glu Lys Glu Asn Asp Thr Gly Val Val His

35 40 45

Gln Val Glu Glu Cys Arg Val Lys Gly Pro Gly Ile Ser Lys Phe Val

50 55 60

Gln Lys Val Asn Glu Ile Gly Ile Tyr Leu Thr Asp Cys Met Glu Arg

65 70 75 80

Ala Arg Glu Val Ile Pro Arg Ser Gln His Gln Glu Thr Pro Val Tyr

85 90 95

Leu Gly Ala Thr Ala Gly Met Arg Leu Leu Arg Met Glu Ser Glu Glu

100 105 110

Leu Ala Asp Arg Val Leu Asp Val Val Glu Arg Ser Leu Ser Asn Tyr

115 120 125

Pro Phe Asp Phe Gln Gly Ala Arg Ile Ile Thr Gly Gln Glu Glu Gly

130 135 140

Ala Tyr Gly Trp Ile Thr Ile Asn Tyr Leu Leu Gly Lys Phe Ser Gln

145 150 155 160

Lys Asn Gln Glu Thr Phe Gly Ala Leu Asp Leu Gly Gly Ala Ser Thr

165 170 175

Gln Val Thr Phe Val Pro Gln Asn Gln Thr Ile Glu Ser Pro Asp Asn

180 185 190

Ala Leu Gln Phe Arg Leu Tyr Gly Lys Asp Tyr Asn Val Tyr Thr His

195 200 205

Ser Phe Leu Cys Tyr Gly Lys Asp Gln Ala Leu Trp Gln Lys Leu Ala

210 215 220

Lys Asp Ile Gln Val Ala Ser Asn Glu Ile Leu Arg Asp Pro Cys Phe

225 230 235 240

His Pro Gly Tyr Lys Lys Val Val Asn Val Ser Asp Leu Tyr Lys Thr

245 250 255

Pro Cys Thr Lys Arg Phe Glu Met Thr Leu Pro Phe Gln Gln Phe Glu

260 265 270

Ile Gln Gly Ile Gly Asn Tyr Gln Gln Cys His Gln Ser Ile Leu Glu

275 280 285

Leu Phe Asn Thr Ser Tyr Cys Pro Tyr Ser Gln Cys Ala Phe Asn Gly

290 295 300

Ile Phe Leu Pro Pro Leu Gln Gly Asp Phe Gly Ala Phe Ser Ala Phe

305 310 315 320

Tyr Phe Val Met Lys Phe Leu Asn Leu Thr Ser Glu Lys Val Ser Gln

325 330 335

Glu Lys Val Thr Glu Met Met Lys Lys Phe Cys Ala Gln Pro Trp Glu

340 345 350

Glu Ile Lys Thr Ser Tyr Ala Gly Val Lys Glu Lys Tyr Leu Ser Glu

355 360 365

Tyr Cys Phe Ser Gly Thr Tyr Ile Leu Ser Leu Leu Gln Gln Gly Tyr

370 375 380

His Phe Thr Ala Asp Ser Trp Glu Asp Ile His Phe Ile Gly Lys Ile

385 390 395 400

Gln Gly Ser Asp Ala Gly Trp Thr Leu Gly Tyr Met Leu Asn Leu Thr

405 410 415

Asn Met Ile Pro Ala Glu Gln Pro Leu Ser Thr Pro Leu Ser His Ser

420 425 430

Thr

<210> 246

<211> 1299

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic polynucleotide"

<400> 246

gcccctacca gcagcagcac ccagaacaag gccctgcccg agaacgtgaa gtacggcatc 60

gtgctggatg ccggcagcag ccacaccagc ctgtacatct acaagtggcc tgccgagaaa 120

gaaaacgaca ccggcgtggt gcatcaggtg gaagagtgca gagtgaaggg ccctggcatc 180

agcaagttcg tgcagaaagt gaacgagatc ggcatctacc tgaccgactg catggaacgg 240

gccagggaag tgatccccag aagccagcac caggaaaccc ccgtgtatct gggagccacc 300

gccggcatga gactgctgag aatggaaagc gaggaactgg ccgaccgggt gctggacgtg 360

gtggaaagaa gcctgagcaa ctacccattc gattttcaag gcgccagaat catcaccggc 420

caggaagaag gcgcctacgg ctggatcacc atcaactacc tgctgggcaa gttcagccag 480

aagaatcagg aaaccttcgg cgccctggac ctgggcggag cttctaccca agtgaccttc 540

gtgccccaga atcagaccat cgagagcccc gacaacgccc tgcagttccg gctgtacggc 600

aaggactaca atgtgtacac ccacagcttt ctgtgctacg gaaaggacca ggctctgtgg 660

cagaagctgg ccaaggacat ccaggtggcc agcaacgaga tcctgcggga cccttgcttc 720

caccccggct acaagaaagt cgtgaacgtg tccgacctgt acaagacccc ctgcaccaag 780

agattcgaga tgaccctgcc cttccagcag ttcgagatcc agggcatcgg caattaccag 840

cagtgccacc agagcatcct ggaactgttc aacaccagct actgccccta cagccagtgc 900

gccttcaacg gcatcttcct gccacctctg cagggggatt tcggcgcctt cagcgccttc 960

tacttcgtga tgaagttcct gaacctgacc agcgagaagg tgtcccagga aaaagtgaca 1020

gagatgatga agaagttctg cgcccagccc tgggaggaaa tcaagacctc ctacgctggc 1080

gtgaaagaga agtacctgag cgagtactgc ttcagcggca cctacatcct gagcctgctg 1140

cagcagggct accacttcac cgccgatagc tgggaggaca tccacttcat cggcaagatt 1200

cagggcagcg acgccggctg gacactgggc tacatgctga atctgaccaa catgatcccc 1260

gccgagcagc ccctgagcac acctctgagc cacagcacc 1299

<210> 247

<211> 6

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide

<400> 247

Glu Phe Arg His Asp Ser

15

<210> 248

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 248

gaattccggc acgacagc 18

<210> 249

<211> 6

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic 6xHis label"

<400> 249

His His His His His His His

15

<210> 250

<211> 18

<212> DNA

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

Synthetic oligonucleotide"

<400> 250

catcatcatc atcatcac 18

<210> 251

<211> 5

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 251

Gly Gly Gly Gly Ser

15

<210> 252

<211> 8

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 252

Val Lys Glu Lys Tyr Leu Ser Glu

15

<210> 253

<211> 7

<212> PROTEIN

<213> Artificial sequence

<220>

<221> source

<223> /note="Description of the artificial sequence:

synthetic peptide"

<400> 253

Gln Glu Arg Trp Leu Arg Asp

15

<---

Claims (20)

1. Solubilized human apyrase containing modifications: N-terminal deletion, C-terminal deletion and modification of the central region, where: a) the length of the N-terminal deletion is from 30 to 50 amino acids, b) the length of the C-terminal deletion is 20 to 40 amino acids, and c) modification of the central region includes a deletion of 10 to 15 consecutive amino acids, where the deletion is a deletion of amino acids 193 to 204 relative to the sequence of wild-type CD39 according to SEQ ID NO: 1, and where the modification of the central region includes a point mutation involving one, two, three, four or five point mutations in relation to the wild-type CD39 sequence according to SEQ ID NO: 1 selected from the group consisting of K71E, N73Q, V95A, G102D, Y104S, T106S, R113M, L149M, V151A, E173D, T229A, L254M, K258R, W263R, E276D, N292Q, R304G, I319T, N327Q, A362N, F365S, N371Q, K405N, Y412F, L424Q, H436D, I437N, F439S, G441D, N457Q, P463S and S469R. 2. Solubilized human apyrase according to claim 1, containing a sequence selected from the group consisting of SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 32, SEQ ID NO: 54, SEQ ID NO: 56, SEQ ID NO: 70, SEQ ID NO: 76 and SEQ ID NO: 78. 3. A solubilized human apyrase according to any one of the preceding claims, comprising a sequence selected from the group consisting of SEQ ID NO: 131, SEQ ID NO: 133, SEQ ID NO: 135, SEQ ID NO: 137, SEQ ID NO: 139, and SEQ ID NO: 141. 4. Solubilized human apyrase according to claim 3, containing or consisting of a sequence selected from the group consisting of SEQ ID NO: 213, SEQ ID NO: 227, SEQ ID NO: 219, SEQ ID NO: 225, SEQ ID NO: 217, SEQ ID NO: 209, SEQ ID NO: 221, SEQ ID NO: 72, SEQ ID NO: 215, SEQ ID NO: 223, SEQ ID NO: 211, SEQ ID NO: 58 and SEQ ID NO: 229. 5. Solubilized human apyrase according to claim 5, consisting of a sequence selected from the group consisting of SEQ ID NO: 58, SEQ ID NO: 72 and SEQ ID NO: 229. 6. Pharmaceutical composition for the treatment of tissue damage, containing a therapeutically effective dose of apyrase according to any one of paragraphs. 1-5 and one or more pharmaceutically acceptable carriers. 7. Pharmaceutical composition according to claim 6, additionally containing one or more additional active ingredients. 8. The pharmaceutical composition according to claim 6, where the tissue damage is an acute brain injury (stroke); acute multiple organ failure; delayed graft function after transplantation of a kidney or other solid organs; burn; radiation damage; acute injury due to trauma and/or hypoxia, such as acute respiratory distress syndrome (ARDS) or lung injury; acute kidney injury, such as acute kidney injury due to chest surgery (eg, aortic valve replacement, coronary artery bypass grafting), or sepsis, or rhabdomyolysis, or toxic effects of antibiotics or other drugs; acute myocardial injury. 9. Selected apyrase according to paragraphs. 1-5 for use in the treatment of acute kidney injury associated with cardiac surgery. 10. Selected apyrase according to paragraphs. 1-5 for use in the treatment of delayed graft function (DGF), acute respiratory distress syndrome (ARDS), acute myocardial infarction (AMI), traumatic brain injury (TBI)/acute ischemic stroke (AIS), ischemia-reperfusion injury ( IRI) or combinations thereof, often referred to as forms of multiple organ failure (MOF). 11. Selected apyrase according to paragraphs. 1-5 for use in the treatment of acute kidney injury associated with sepsis. 12. An isolated nucleic acid molecule encoding any apyrase according to paragraphs. 1-5. 13. A cloning vector containing one or more nucleic acid sequences according to paragraph 12, where the vector is suitable for recombinant production of the isolated apyrase according to paragraphs. 1-5. 14. An expression vector containing one or more nucleic acid sequences according to paragraph 12, where the vector is suitable for recombinant production of the isolated apyrase according to paragraphs. 1-5. 15. The host cell for obtaining apyrase according to paragraphs. 1-5 containing one or more cloning or expression vectors according to claim 13 or 14. 16. The method of obtaining apyrase according to any one of paragraphs. 1-5, including culturing the host cell according to claim 15, purifying and extracting said apyrase.

Images