RU2772747C9 - Device for manual packing of tablet dosage forms - Google Patents

Abstract

FIELD: medical technology.

SUBSTANCE: invention relates to medical technology. The device for manual packing of solid pharmaceutical tablet forms into the cells of the thermoformed plastic part of the blister is a rectangular packing web with walls to hold the packaged tablets, containing packing cells, an intermediate storage hopper of the packing unit and protrusions on the sides of the packing web for ease of manipulation during manual packing. The packing cell is an opening having on one side a protrusion made in the lower part, and on the other side a beveled face. The diameter of the opening of the packing cell d_op is calculated by formula I:

where d_tab is the diameter of the packing unit, and the size of the side of the protrusion l_sp is calculated by formula II:

where d_tab is the diameter of the packing unit.

EFFECT: simplifying the precise manual positioning of tablet forms inside the containers of the cells of the thermoformed plastic part of the blister.

5 cl, 4 dwg, 1 tbl

Description

The present invention relates to the field of pharmaceutical technology, namely to the field of packaging dosage forms, in particular to a device for filling tablet dosage forms into cells of a thermoformed plastic part of a blister.

Pharmaceutical technology is an integral part of pharmaceutical science, which is a system of scientific knowledge about the discovery, properties, production, analysis, storage and sale of pharmaceutical products.

The main tasks of pharmaceutical technology are:

- study of the theoretical foundations and development of technological methods for the production of new pharmaceutical substances and preparations;

- improvement of existing drugs and technologies for their production;

- search, study and use of new excipients in the production of medicines;

- study of stability and establishment of expiration dates of medicinal substances, preparations, semi-finished products and other products;

- study of the efficiency of the technological process, the main indicators of which are: the degree of use of raw materials, energy and labor costs per unit of output; yield and quality of finished products; the intensity of the process; production cost and other [Chueshov V.I. Technology of drugs for industrial production: a textbook for students. higher textbook manager: translation from Ukrainian. lang. Part 1 - Vinnitsa: New Book, 2014. - p. 696 // https://studfile.net/preview/6761345/].

Packaging and packaging of medicines are divided into several types and groups. This division depends on the materials used, their mechanical strength and stability, which ensure maximum safety of medicinal products, as well as the purpose of use (laboratory / mass production of medicinal products).

Mass production of medicines is possible subject to the use of various machines and mechanisms, that is, in pharmaceutical enterprises: factories or plants. On the basis of the latest scientific discoveries, fundamentally new, more advanced and productive technological processes are being created that dramatically increase labor productivity and improve the quality of finished products. Modern conditions require the development of low-operation, resource-saving and waste-free processes, maximum mechanization, automation and computerization.

Containers and packaging in pharmacy play an important role, providing both the possibility of convenient use of medicines and maintaining proper quality during storage [Packaging of medicines: A textbook on pharmaceutical technology / G.V. Ayupova and others - Ufa; Publishing house of Bashgosmededuniversity, 2009 - 91 p.].

Usually, solid dosage forms are packed in contour containers, glass jars with a screw neck, and polymer containers. The most commonly used type of packaging for many solid dosage forms is a blister pack ("blister"), which provides reliable storage of drugs and maximum microbiological purity. In this case, usually the packaging of dosage forms in the selected container is carried out at the expense of specialized filling machines.

Laboratory production (pharmacies, research institutes, laboratories of pharmaceutical production, etc.), filling and packaging of medicines implies manual laboratory-packing work.

So, for example, in industrial pharmacies there are packing rooms. A filling room is usually understood as a room in which dosing and packaging of medicines produced by a pharmacy, or products that come in bulk form, are carried out. With a small amount of the recipe, employees perform laboratory and packaging work in the assistant or aseptic rooms. To improve the quality of work of pharmacists-technologists and packers and increase their productivity, it is recommended to equip workplaces with various mechanization tools and devices. The equipment of the premises should take into account the types of laboratory and filling work carried out by laboratory personnel, since the volume of products is much less than on an industrial scale, and often the premises do not allow the placement of filling and packaging machines.

Thus, the creation of devices that accelerate and simplify the production, packaging and packaging of dosage forms in the laboratory is an urgent task.

From the prior art (GB756971A (03.12.1954)) a device for screening solid particles is known, which contains a pair of perforated mesh blocks superimposed on each other, at least in the screening zone, while the perforations of each module have the correct orientation and in each module is larger than the desired sifting size, in addition, the two blocks can move relative to each other to the first position. This device allows you to sort objects by size, but does not allow you to pack tablet forms in a blister.

From the prior art (CN109530214A (24.12.2018)) a device for automatic tablet selection is known, which contains a sifting mechanism, a conveyor mechanism, a weighing mechanism, an unqualified box, a collection box and a control system, while the sifting mechanism contains a main body of a sieve tray and a vibration exciter connected with the main body of the sieve tray, and the main body of the sieve plate is composed of the upper sieve plate and the lower sieve plate. This device requires operator skill and is not suitable for manual filling.

From the prior art (US2012031815 A1 (05.08.2010)) a system for sorting tablets for unloading a plurality of tablets is known. The system includes a sorting tray having a sorting area for receiving a plurality of tablets and an unloading area including a spout configured to unload pills from the tray. The system also includes a handheld stylus having a body with first and second ends. The first end contains an adhesive for gripping the pill, and the second end is adapted to sort and move the pills within the tray and through the spout. However, this device does not provide accelerated packaging of tablet dosage forms.

From the prior art (US9456957 B2 (04.10.2016)) a device is known that includes a mechanism for orienting a plurality of capsules, having at least one sheet component for orienting capsules and at least one base component for directing oriented capsules to next mechanism. The capsule orientation mechanism can be adapted to a manual capsule filling assembly or a tabletop capsule filling assembly. The capsule filling mechanism may further include a capsule loading tray and a locking plate. However, the use of this device is possible only for the orientation of the capsules.

Thus, prior art filling devices are predominantly complex in design, requiring operator skill and machine maintenance, or are not suitable for quick manual filling of tablets in a blister container.

The technical objective of the present invention is the development of a device that has a simple design and does not require special skills of the operator and maintenance of the mechanisms, which allows you to accurately position the tablet forms inside the containers of the blister cells to increase the speed and quality of manual packaging of tablet dosage forms into the cells of the thermoformed plastic part of the blister.

The solution of the problem is achieved by means of a device for manual filling of solid dosage tablet forms (tablets) into the cells of the thermoformed plastic part of the blister, which is a rectangular packing sheet with walls, containing an array of filling cells, a bin for intermediate storage of packed tablets and protrusions on the sides of the filling sheet for ease of manipulation during operation with the device, while the filling cell is a hole, the size of which is calculated relative to the dimensions of the packing unit, and has a restrictive protrusion (stopper) on one side in the lower part of the hole and, on the opposite side, a beveled edge of the hole.

The technical result of the claimed invention consists in the simplified and accelerated manual filling of tablet dosage forms into the cells of the thermoformed plastic part of the blister due to the design features of the claimed device, which provides ease of manipulation by the operator during manual filling of tablet dosage forms, accurate positioning of the tablet forms inside the containers of the blister cells and prevention of falling excess packing unit into an already filled cell, ensuring easy removal of the excess packing unit.

To create a device according to the present invention, Flex-CAD CAD tools (educational version of the software) were used, and a 3D printer and PLA and PETG plastic filament (filament diameter 1.75 mm) were used for prototyping.

The design of the manual filling device is a rectangular packing sheet, which includes an array of filling cells equal to the number of cells in the thermoformed base of the blister. In addition, on three sides of the packing web there are walls for holding packed tablets within the boundaries of the device, and on one side there is a hopper for intermediate storage of packed tablets. On both sides, the device contains protrusions for ease of manipulation by the operator during manual packaging.

The design of the packing cell is a hole calculated relative to the dimensions of the packing unit. In this case, the diameter of the opening of the filling cell (d _resp ) is calculated by formula (I):

where d _tab is the diameter of the packing unit.

In addition, the filling cell has a stopper on one side in the lower part of the hole - a protrusion that can be made in the form of a square, triangle, rectangle, and on the opposite side - a beveled (inclined) edge of the hole, while the angle of the bevel of the edge of the opening of the filling cell is from 2 to 6 degrees.

The size of the side of the protrusion-stopper (l _cx ) is calculated by the formula (II):

where d _resp - the diameter of the packaging unit.

Thus, this design of the filling cell prevents the excess filling unit (tablet) from falling into the blister cell already filled with the tablet, i.e. ensures the filling of the blister cell with only one tablet and ensures easy removal of the excess packing unit into the hopper of the device.

The material for the manufacture of the device can be selected from sheet metal or plastic (thermoplastic, thermoplastic), the thickness of the packing sheet is from 0.5 to 8 mm.

The drawings show an embodiment of the proposed device, which does not exclude the possibility of using other overall dimensions of the device, depending on the size of the packed tablet forms and the filled blister. Likewise, it is contemplated that other projection configurations may be used for ease of manipulation by the operator during manual filling, within the scope of the present invention. In any case, such configurations are clear enough to those skilled in the art.

Fig. 1 - Schematic diagram of a device for manual filling of solid dosage tablet forms. 1 - packing web, 2 - packing cell, 3 - hopper for intermediate storage, 4 - protrusions.

Fig. 2 - Schematic diagram of the packing cell. 5 - protrusion-stopper, 6 - hole, 7 - beveled edge.

Fig. 3 - The design of the device for manual packaging of solid dosage tablet forms (option).

Fig. 4 - Design of the filling cell (option).

Example.

The principle of operation of the claimed device is as follows:

1. The operator pours at least twice the amount of tablets required to fill the blister into the intermediate storage bin.

2. The operator shakes the device several times and shifts it away from him, so that the "extra tablets" falling into the cells are removed by an inclined edge.

3. The operator tilts the device towards the hopper and the "extra tablets" are poured into the hopper.

4. The operator removes the blister blank filled with tablets. As a result of the tests carried out at the experimental industrial site of the OPU), during which manual filling methods were compared using tweezers and using the accelerated manual filling device claimed according to the present invention, it was found that the use of the claimed device allows you to speed up the process of packing tablets by 1.54 times.

Claims (10)

1. A device for manual filling of solid dosage tablet forms into the cells of the thermoformed plastic part of the blister, which is a rectangular filling sheet with walls to hold the packed tablets, containing filling cells, an intermediate storage bin for the filling unit and protrusions on the sides of the filling sheet for ease of manipulation during manual packing, the packing cell is a hole having on one side a protrusion made in the lower part, and on the other hand - a beveled edge, while the diameter of the opening of the filling cell d holes _. calculated by formula I:

where d _tab is the diameter of the packing unit, and the size of the protrusion side l _st is calculated by formula II:

where d _tab is the diameter of the packing unit. 2. The device according to claim 1, in which the number of packing cells on the packing web is equal to the number of cells in the thermoformed base of the blister. 3. The device according to claim. 1, in which the shape of the protrusion is a square, triangle, rectangle. 4. The device according to claim 1, in which the bevel angle of the beveled edge of the opening of the filling cell is from 2 to 6 degrees. 5. The device according to claim 1, in which the thickness of the packing web is from 0.5 to 8 mm.

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