RU2613324C3 - Композиция для контролируемой стимуляции яичников - Google Patents
Композиция для контролируемой стимуляции яичниковInfo
- Publication number
- RU2613324C3 RU2613324C3 RU2014102924A RU2014102924A RU2613324C3 RU 2613324 C3 RU2613324 C3 RU 2613324C3 RU 2014102924 A RU2014102924 A RU 2014102924A RU 2014102924 A RU2014102924 A RU 2014102924A RU 2613324 C3 RU2613324 C3 RU 2613324C3
- Authority
- RU
- Russia
- Prior art keywords
- sialylation
- drug
- fsh
- patient
- total
- Prior art date
Links
- 230000002611 ovarian Effects 0.000 title 1
- 230000000638 stimulation Effects 0.000 title 1
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 8
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 8
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 5
- 229940079593 drug Drugs 0.000 claims 4
- 230000009450 sialylation Effects 0.000 claims 4
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 208000000509 infertility Diseases 0.000 claims 2
- 230000036512 infertility Effects 0.000 claims 2
- 231100000535 infertility Toxicity 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal cation Chemical class 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (3)
1. Применение фолликулостимулирующего гормона (ФСГ) в изготовлении лекарственного средства для лечения бесплодия у пациента, имеющего сывороточный уровень антимюллеровского гормона (АМГ) менее 15 пмоль/л, где лекарственное средство содержит суточную дозу, равную 12 мкг рекомбинантного ФСГ, причем указанный рекомбинантный ФСГ включает α2,3- и α2,6-сиалирование, где от 84,24 до 88,5% общего сиалирования представляет собой α2,3-сиалирование и от 11,5 до 15,76% общего сиалирования представляет собой α2,6-сиалирование.
2. Применение фолликулостимулирующего гормона (ФСГ) в изготовлении лекарственного средства для лечения бесплодия у пациента, имеющего сывороточный уровень антимюллеровского гормона (АМГ) не менее 15 пмоль/л, где лекарственное средство предназначено для введения в суточной дозе, равной от 0,10 до 0,19 мкг рекомбинантного ФСГ человеческого происхождения на кг массы тела пациента, причем указанный рекомбинантный ФСГ включает α2,3- и α2,6-сиалирование, где от 84,24 до 88,5% общего сиалирования представляет собой α2,3-сиалирование и от 11,5 до 15,76% общего сиалирования представляет собой α2,6-сиалирование.
3. Применение по п. 1 или 2, где лекарственное средство дополнительно содержит соль, содержащую фармацевтически приемлемый катион щелочного металла и представляющую собой соль Na+.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11176803.2 | 2011-08-08 | ||
| EP11176803 | 2011-08-08 | ||
| PCT/EP2012/065507 WO2013020996A1 (en) | 2011-08-08 | 2012-08-08 | Composition for controlled ovarian stimulation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017106756A Division RU2739037C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2014102924A RU2014102924A (ru) | 2015-09-20 |
| RU2613324C2 RU2613324C2 (ru) | 2017-03-15 |
| RU2613324C3 true RU2613324C3 (ru) | 2021-06-09 |
Family
ID=46785372
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017106756A RU2739037C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
| RU2014102924A RU2613324C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017106756A RU2739037C3 (ru) | 2011-08-08 | 2012-08-08 | Композиция для контролируемой стимуляции яичников |
Country Status (30)
| Country | Link |
|---|---|
| US (5) | US9694052B2 (ru) |
| EP (9) | EP4005588B1 (ru) |
| JP (5) | JP6161609B2 (ru) |
| KR (8) | KR20190140098A (ru) |
| CN (2) | CN107281470A (ru) |
| AR (1) | AR087476A1 (ru) |
| AU (3) | AU2012293647B2 (ru) |
| BR (2) | BR112014002884A2 (ru) |
| CA (1) | CA2844282A1 (ru) |
| CY (1) | CY1117214T1 (ru) |
| DK (8) | DK3646881T3 (ru) |
| ES (8) | ES2562648T3 (ru) |
| FI (2) | FI4005588T3 (ru) |
| HR (8) | HRP20240420T1 (ru) |
| HU (8) | HUE027674T2 (ru) |
| IL (2) | IL300380A (ru) |
| JO (1) | JO3092B1 (ru) |
| LT (7) | LT3756681T (ru) |
| MX (5) | MX348981B (ru) |
| PL (8) | PL2741763T3 (ru) |
| PT (6) | PT3646881T (ru) |
| RS (8) | RS59107B1 (ru) |
| RU (2) | RU2739037C3 (ru) |
| SA (1) | SA112330762B1 (ru) |
| SI (8) | SI3566712T1 (ru) |
| SM (1) | SMT201600038B (ru) |
| TR (2) | TR201900071T4 (ru) |
| TW (2) | TWI555530B (ru) |
| WO (1) | WO2013020996A1 (ru) |
| ZA (2) | ZA201400952B (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) * | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| JP2018500934A (ja) * | 2014-12-22 | 2018-01-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｍｐ依存性シアリダーゼ活性 |
| ES2879838T3 (es) * | 2015-04-17 | 2021-11-23 | Ferring Bv | Composición que comprende FSH para el tratamiento de la esterilidad |
| CN107709350A (zh) | 2015-06-26 | 2018-02-16 | 辉凌公司 | 纯化和/或病毒灭活的方法 |
| CN108348465B (zh) * | 2015-09-17 | 2020-11-10 | 葛莱高托普有限公司 | 具有提高的稳定性的哺乳动物促卵泡激素组合物 |
| IL265696B2 (en) * | 2016-09-30 | 2024-08-01 | Sumitomo Pharma Switzerland Gmbh | 2-(n-acetyl-d-tyrosyl-trans-4-hydroxy-l-prolyl-l-asparaginyl-l-threonyl-l-phenylalanyl) hydrazinocarbonyl-l-leucyl-nω-methyl-l-arginyl-l-tryptophanamide, for use in assisted reproductive technology. |
| ES2989511T3 (es) * | 2017-09-01 | 2024-11-26 | Ferring Bv | Composición para la estimulación ovárica controlada |
| EP4534145A3 (en) | 2018-04-30 | 2025-07-02 | Ferring B.V. | Composition for controlled ovarian stimulation |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| US11576920B2 (en) | 2019-03-18 | 2023-02-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| CN110841060A (zh) * | 2019-11-21 | 2020-02-28 | 上海交通大学 | Choriogonadotropin alfa在治疗多囊卵巢综合征中的应用 |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| EP4504236A1 (en) | 2022-04-01 | 2025-02-12 | Ferring B.V. | Mixed protocol for treatment of infertility |
| JP2025516966A (ja) | 2022-05-26 | 2025-05-30 | フェリング ベスローテン フェンノートシャップ | 男性の不妊症の治療のための組成物及び方法 |
| EP4551244A1 (en) | 2022-07-08 | 2025-05-14 | Ferring B.V. | Compositions and methods for intrauterine insemination (iui) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW518235B (en) | 1997-01-15 | 2003-01-21 | Akzo Nobel Nv | A gonadotropin-containing pharmaceutical composition with improved stability on prolong storage |
| EP1074265A1 (en) * | 1999-08-03 | 2001-02-07 | Erasmus Universiteit Rotterdam | Use of AMH and/or AMH agonists and/or AMH antagonists for long-term control of female fertility |
| AU2002340562B2 (en) * | 2001-10-22 | 2008-10-23 | Merck Serono Sa | Compositions of FSH with high sialylation degree and their use for the preparation of medicaments |
| US20040248784A1 (en) * | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| US8501719B2 (en) * | 2005-11-08 | 2013-08-06 | American Infertility Of New York | Androgen treatment in females |
| TWI488640B (zh) * | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI604850B (zh) * | 2009-10-05 | 2017-11-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| DE102010007984B4 (de) | 2010-02-15 | 2012-01-26 | Hochland Ag | Form- und Kühlvorrichtung für eine fließfähige, aufgeschmolzene Lebensmittelmasse |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| HUE025514T2 (en) * | 2010-09-29 | 2016-02-29 | Ferring Bv | Preparation for use in treating infertility |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
-
2012
- 2012-07-18 JO JOP/2012/0197A patent/JO3092B1/ar active
- 2012-07-23 TW TW101126453A patent/TWI555530B/zh active
- 2012-07-23 TW TW105124123A patent/TWI657822B/zh active
- 2012-08-07 SA SA112330762A patent/SA112330762B1/ar unknown
- 2012-08-07 AR ARP120102883A patent/AR087476A1/es not_active Application Discontinuation
- 2012-08-08 EP EP21207717.6A patent/EP4005588B1/en active Active
- 2012-08-08 ES ES12753675.3T patent/ES2562648T3/es active Active
- 2012-08-08 PL PL12753675T patent/PL2741763T3/pl unknown
- 2012-08-08 SI SI201231884T patent/SI3566712T1/sl unknown
- 2012-08-08 EP EP18167552.1A patent/EP3395357B1/en active Active
- 2012-08-08 RS RS20191038A patent/RS59107B1/sr unknown
- 2012-08-08 DK DK19213649.7T patent/DK3646881T3/da active
- 2012-08-08 LT LTEP20186935.1T patent/LT3756681T/lt unknown
- 2012-08-08 KR KR1020197036505A patent/KR20190140098A/ko not_active Ceased
- 2012-08-08 ES ES19213649T patent/ES2884947T3/es active Active
- 2012-08-08 LT LTEP19213649.7T patent/LT3646881T/lt unknown
- 2012-08-08 ES ES21207717T patent/ES2977682T3/es active Active
- 2012-08-08 PL PL19164277T patent/PL3566712T3/pl unknown
- 2012-08-08 DK DK17154031.3T patent/DK3195875T3/en active
- 2012-08-08 WO PCT/EP2012/065507 patent/WO2013020996A1/en not_active Ceased
- 2012-08-08 HU HUE12753675A patent/HUE027674T2/en unknown
- 2012-08-08 HU HUE21207717A patent/HUE066158T2/hu unknown
- 2012-08-08 PT PT192136497T patent/PT3646881T/pt unknown
- 2012-08-08 DK DK21207717.6T patent/DK4005588T5/da active
- 2012-08-08 TR TR2019/00071T patent/TR201900071T4/tr unknown
- 2012-08-08 ES ES17154031.3T patent/ES2692774T3/es active Active
- 2012-08-08 EP EP12753675.3A patent/EP2741763B1/en active Active
- 2012-08-08 SI SI201232033T patent/SI3756681T1/sl unknown
- 2012-08-08 PL PL17154031T patent/PL3195875T3/pl unknown
- 2012-08-08 ES ES19164277T patent/ES2871405T3/es active Active
- 2012-08-08 FI FIEP21207717.6T patent/FI4005588T3/fi active
- 2012-08-08 DK DK20186935.1T patent/DK3756681T5/da active
- 2012-08-08 PT PT201869351T patent/PT3756681T/pt unknown
- 2012-08-08 LT LTEP21207717.6T patent/LT4005588T/lt unknown
- 2012-08-08 SI SI201231398T patent/SI3195875T1/sl unknown
- 2012-08-08 PT PT17154031T patent/PT3195875T/pt unknown
- 2012-08-08 MX MX2014001489A patent/MX348981B/es active IP Right Grant
- 2012-08-08 ES ES18167552T patent/ES2742163T3/es active Active
- 2012-08-08 DK DK14184409.2T patent/DK2821080T3/en active
- 2012-08-08 LT LTEP18167552.1T patent/LT3395357T/lt unknown
- 2012-08-08 CA CA2844282A patent/CA2844282A1/en active Pending
- 2012-08-08 KR KR1020217037512A patent/KR102499969B1/ko active Active
- 2012-08-08 RS RS20230518A patent/RS64328B1/sr unknown
- 2012-08-08 KR KR1020207029774A patent/KR20200121918A/ko not_active Ceased
- 2012-08-08 PL PL14184409T patent/PL2821080T3/pl unknown
- 2012-08-08 DK DK18167552.1T patent/DK3395357T3/da active
- 2012-08-08 HU HUE19164277A patent/HUE053716T2/hu unknown
- 2012-08-08 EP EP17154031.3A patent/EP3195875B1/en active Active
- 2012-08-08 HR HRP20240420TT patent/HRP20240420T1/hr unknown
- 2012-08-08 KR KR1020217023662A patent/KR102353144B1/ko active Active
- 2012-08-08 HU HUE20186935A patent/HUE062640T2/hu unknown
- 2012-08-08 RU RU2017106756A patent/RU2739037C3/ru active Protection Beyond IP Right Term
- 2012-08-08 CN CN201710306350.4A patent/CN107281470A/zh active Pending
- 2012-08-08 KR KR1020147005938A patent/KR102014469B1/ko active Active
- 2012-08-08 KR KR1020237004855A patent/KR20230024442A/ko not_active Ceased
- 2012-08-08 ES ES20186935T patent/ES2950911T3/es active Active
- 2012-08-08 EP EP23208228.9A patent/EP4306174A3/en active Pending
- 2012-08-08 KR KR1020257026973A patent/KR20250126867A/ko active Pending
- 2012-08-08 EP EP20186935.1A patent/EP3756681B1/en active Active
- 2012-08-08 TR TR2019/11269T patent/TR201911269T4/tr unknown
- 2012-08-08 FI FIEP20186935.1T patent/FI3756681T3/fi active
- 2012-08-08 RS RS20210603A patent/RS61843B1/sr unknown
- 2012-08-08 EP EP14184409.2A patent/EP2821080B1/en active Active
- 2012-08-08 SI SI201231493T patent/SI2821080T1/sl unknown
- 2012-08-08 BR BR112014002884A patent/BR112014002884A2/pt not_active Application Discontinuation
- 2012-08-08 PL PL20186935.1T patent/PL3756681T3/pl unknown
- 2012-08-08 AU AU2012293647A patent/AU2012293647B2/en active Active
- 2012-08-08 PT PT18167552T patent/PT3395357T/pt unknown
- 2012-08-08 HR HRP20230607TT patent/HRP20230607T1/hr unknown
- 2012-08-08 LT LTEP14184409.2T patent/LT2821080T/lt unknown
- 2012-08-08 EP EP19164277.6A patent/EP3566712B1/en active Active
- 2012-08-08 US US14/237,697 patent/US9694052B2/en active Active
- 2012-08-08 SI SI201232063T patent/SI4005588T1/sl unknown
- 2012-08-08 HU HUE17154031A patent/HUE040058T2/hu unknown
- 2012-08-08 PT PT14184409T patent/PT2821080T/pt unknown
- 2012-08-08 RS RS20181263A patent/RS57897B1/sr unknown
- 2012-08-08 SI SI201231921T patent/SI3646881T1/sl unknown
- 2012-08-08 PL PL19213649T patent/PL3646881T3/pl unknown
- 2012-08-08 HR HRP20160145TT patent/HRP20160145T1/hr unknown
- 2012-08-08 SI SI201230438T patent/SI2741763T1/sl unknown
- 2012-08-08 CN CN201280038831.7A patent/CN103732243A/zh active Pending
- 2012-08-08 RS RS20160080A patent/RS54561B1/sr unknown
- 2012-08-08 RS RS20210425A patent/RS61672B1/sr unknown
- 2012-08-08 MX MX2017004482A patent/MX381278B/es unknown
- 2012-08-08 HU HUE18167552 patent/HUE044610T2/hu unknown
- 2012-08-08 KR KR1020197024335A patent/KR102111514B1/ko active Active
- 2012-08-08 PT PT212077176T patent/PT4005588T/pt unknown
- 2012-08-08 PL PL21207717.6T patent/PL4005588T3/pl unknown
- 2012-08-08 PL PL18167552T patent/PL3395357T3/pl unknown
- 2012-08-08 DK DK12753675.3T patent/DK2741763T3/da active
- 2012-08-08 SI SI201231653T patent/SI3395357T1/sl unknown
- 2012-08-08 EP EP19213649.7A patent/EP3646881B1/en active Active
- 2012-08-08 JP JP2014524372A patent/JP6161609B2/ja active Active
- 2012-08-08 HU HUE14184409A patent/HUE041769T2/hu unknown
- 2012-08-08 LT LTEP17154031.3T patent/LT3195875T/lt unknown
- 2012-08-08 RU RU2014102924A patent/RU2613324C3/ru active Protection Beyond IP Right Term
- 2012-08-08 LT LTEP19164277.6T patent/LT3566712T/lt unknown
- 2012-08-08 RS RS20240487A patent/RS65485B1/sr unknown
- 2012-08-08 RS RS20190006A patent/RS58198B1/sr unknown
- 2012-08-08 ES ES14184409T patent/ES2704878T3/es active Active
- 2012-08-08 IL IL300380A patent/IL300380A/en unknown
- 2012-08-08 HU HUE19213649A patent/HUE054312T2/hu unknown
- 2012-08-08 DK DK19164277.6T patent/DK3566712T3/da active
- 2012-08-08 BR BR122020001644-2A patent/BR122020001644B1/pt active IP Right Grant
-
2014
- 2014-01-28 IL IL230696A patent/IL230696B2/en unknown
- 2014-02-06 MX MX2024008826A patent/MX2024008826A/es unknown
- 2014-02-06 MX MX2020010991A patent/MX2020010991A/es unknown
- 2014-02-06 MX MX2024008825A patent/MX2024008825A/es unknown
- 2014-02-07 ZA ZA2014/00952A patent/ZA201400952B/en unknown
-
2015
- 2015-09-01 ZA ZA2015/06382A patent/ZA201506382B/en unknown
-
2016
- 2016-02-10 SM SM201600038T patent/SMT201600038B/it unknown
- 2016-02-18 CY CY20161100142T patent/CY1117214T1/el unknown
- 2016-12-15 AU AU2016273925A patent/AU2016273925B2/en active Active
-
2017
- 2017-03-16 JP JP2017051062A patent/JP6500050B2/ja active Active
- 2017-06-29 US US15/637,962 patent/US10624953B2/en active Active
-
2018
- 2018-05-09 AU AU2018203222A patent/AU2018203222B2/en active Active
- 2018-10-10 HR HRP20181639TT patent/HRP20181639T1/hr unknown
- 2018-12-27 JP JP2018243912A patent/JP6718951B2/ja active Active
-
2019
- 2019-01-03 HR HRP20190023TT patent/HRP20190023T1/hr unknown
- 2019-08-08 HR HRP20191437 patent/HRP20191437T1/hr unknown
-
2020
- 2020-04-17 US US16/851,260 patent/US11291708B2/en active Active
- 2020-06-15 JP JP2020102938A patent/JP7309660B2/ja active Active
-
2021
- 2021-02-18 HR HRP20210277TT patent/HRP20210277T1/hr unknown
- 2021-05-10 HR HRP20210722TT patent/HRP20210722T1/hr unknown
-
2022
- 2022-03-30 US US17/709,305 patent/US12478660B2/en active Active
-
2023
- 2023-07-05 JP JP2023110411A patent/JP2023134561A/ja active Pending
-
2025
- 2025-01-03 US US19/009,834 patent/US20250302923A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2613324C3 (ru) | Композиция для контролируемой стимуляции яичников | |
| HK1221646A1 (zh) | 高剂量普利多匹定用於治疗亨廷顿舞蹈症的用途 | |
| MX2017004592A (es) | Formulaciones farmaceuticas para la administracion oral de farmacos peptidicos o proteinicos. | |
| NZ599558A (en) | Dosing regimen associated with long-acting injectable paliperidone esters | |
| WO2013101897A3 (en) | Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid | |
| FI3229828T3 (fi) | Glargiini-insuliinin/liksisenatidin vakiosuhteinen formulaatio | |
| EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
| WO2009033711A3 (en) | Use of glp-1 as a therapeutic agent | |
| WO2009033770A3 (en) | Calcitonin c-terminal flanking peptide for use as a therapeutic agent | |
| MX2010013766A (es) | Rasagilina para modificacion de enfermedad de parkinson. | |
| RU2017123880A (ru) | Антагонисты миостатина или активина для лечения саркопении | |
| NZ613291A (en) | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof | |
| WO2015085143A3 (en) | Therapeutic agents for skin diseases and conditions | |
| MD4369B1 (ru) | Использование гликопирролата для лечения тахикардии, одноразовая доза, устройство для введения, метод лечения и профилактики тахикардии | |
| RU2013137645A (ru) | Аналоги цистамина, применяемые для лечения болезни паркинсона | |
| HRP20192189T1 (hr) | Doziranja i terapijske primjene l-4-klorokinurenina | |
| JP2014508758A5 (ru) | ||
| RU2013127420A (ru) | Способы уменьшения психогенного или компульсивного переедания | |
| HK1203394A1 (en) | Ghrelin receptor agonists for the treatment of achlorhydria | |
| JP2014520874A5 (ru) | ||
| MX2013003523A (es) | Composicion farmaceutica de dosis baja. | |
| MX2018013475A (es) | Acido carboxilico para tratar/prevenir congestion nasal. | |
| NZ710583A (en) | Use of tungsten (vi) salts for the treatment of female infertility in non-diabetic mammals | |
| FI3973982T3 (fi) | Koostumus munasarjojen kontrolloituun stimulaatioon | |
| FI3654989T3 (fi) | Kladribiinin käyttö neuromuskulaarisen autoimmuunisairauden hoitoon |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ND4A | Extension of patent duration |
Effective date: 20210609 |