RU2601114C1 - Therapeutic composition for oral care during diabetes - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to dentistry and represents a therapeutic composition for oral care at diabetes mellitus, characterised by the fact that it contains allantoin, a flavoring agent, potassium sorbate, xylitol, citric acid, sodium lauroyl sarcosinate, sodium methylparaben, sodium saccharinate, sodium fluoride, natria citrate, polyvinyl pyrrolidone, PEG-40, trilon B, Phytessence Stevia GL, Phytoliquid Fucus P and water, ingredients of the composition taken in certain proportions, wt%.

EFFECT: invention provides extending the range of products for oral care at diabetes mellitus, higher stability, safety and efficiency.

3 cl

Description

The invention relates to the field of dentistry, more specifically, to compositions for caring for the oral cavity, specifically for the prevention and treatment of the effects of diabetes.

Analogues of the invention and the prototype are not identified.

The invention is aimed at solving the technical problem of obtaining for the first time a therapeutic composition for caring for the oral cavity in diabetes mellitus.

The stated technical problem is solved in that the treatment and prophylactic composition for caring for the oral cavity in diabetes mellitus contains allantoin, flavoring, potassium sorbate, xylitol, citric acid, sodium lauryl sarcosinate, sodium methyl paraben, sodium saccharin, sodium fluoride, sodium citrate, polyvinylpyrrolidone, PEG -40, Trilon B, Phytessence Stevia GL, Phytoliquid Fucus P and water in the following proportions, wt. %:

allantoin 0.05-0.15 flavoring 0.4-0.6 potassium sorbate 0.1-0.3 xylitol 10.0-20.0 lemon acid 0.05-0.15 sodium lauryl sarcosinate 0.7-0.9 sodium methylparaben 0.05-0.15 sodium saccharinate 0.05-0.15 sodium fluoride 0.05-0.15 sodium citrate 0.7-0.9 polyvinylpyrrolidone 3.0-5.0 PEG-40 1.0-3.0 Trilon B 0.05-0.15 Phytessence Stevia GL 1.0-3.0 Phytoliquid Fucus P 1.0-3.0 water up to 100

In particular cases of the invention:

- therapeutic and prophylactic composition additionally contains kosfaderm in the amount of (0.1-0.3)% of the total mass;

- therapeutic and prophylactic composition additionally contains Phytoliquid Rhatany in the amount of (1.0-3.0)% of the total mass.

A technical result is expected from the invention, which coincides with the essence of the problem being solved, namely, obtaining for the first time a therapeutic and prophylactic composition for caring for the oral cavity in diabetes mellitus.

One of the serious consequences of diabetes is multiple caries, and therefore sodium fluoride, an effective anti-caries agent of toothpastes, is included in the composition of the LPC. The fluorine contained in it suppresses the acidic environment in which harmful bacteria multiply. Fluoride also strengthens teeth by mineralizing enamel. As a result, the incidence of caries decreases, the formation of cavities is prevented, and the development of existing lesions slows down.

The proportion of sodium fluoride in the LPC is relatively small, which eliminates the possibility of adverse side effects inherent in fluoride. But its small content is compensated by the presence of xylitol in the LPC - in a significant amount, in which the anti-caries properties of this compound are manifested. The alkaline medium created by it suppresses the bacterium that causes tooth decay. Xylitol is also effective against fungal candidiasis and periodontitis, eliminates halitosis. Xylitol promotes the mineralization of enamel and also stimulates the production of saliva, which prevents xerostomia characteristic of diabetes.

Among the active agents, LPK contains plant extracts of Phytessence Stevia GL and Phytoliquid Fucus P. The first of these agents is an extract of stevia, otherwise called honey grass, which grows in many parts of the world with a warm and temperate climate. Due to the presence of flavonoids, stevia extract has an antioxidant, tonic and moisturizing effect on the tissues of the oral cavity. The contained minerals contribute to the mineralization of the teeth. It is known that the use of stevia extract in diabetes prevents the development of hypoglycemic and hyperglycemic conditions, and reduces the dose of insulin. The second agent mentioned is an extract of bubbly fucus - seaweed with a whole complex of biologically active substances: polysaccharides, minerals, proteins, amino acids, antioxidants, vitamins. They have an antibacterial and moisturizing effect.

In the particular case of the invention, the LPC may contain Cosfaderm (trade name Cosphaderm® Magnolia Extract 98). This active agent contains magnolol and honokiol, the main polyphenolic compounds of the magnolia plant, which provide a wide spectrum of cosfaderm action: antibacterial, antifungal, anti-inflammatory, antioxidant effects. Cosfaderm suppresses bacteria and the GTF enzyme that contribute to tooth decay. Cosfaderm is added to the complex if necessary to reduce pain from tissue inflammation and eliminate bad breath.

Phytoliquid Rhatany (a special case of the invention) can be added to the flavors for extremely sensitive teeth. This product, an extract of the ratany plant, is also able to prevent bleeding of the gums.

The action of plant extracts is supplemented by the introduction of a small amount of allantoin into the forest complex. This active agent is characterized by anti-inflammatory and antioxidant activity, has a softening and moisturizing effect on tissues, has a pronounced healing effect, stimulates the regeneration of gums and oral mucosa.

A significant amount of the active agent polyvinylpyrrolidone contained in the LPC effectively dissolves the protein-lipid base of dental plaque, eliminates the pathogenic microflora of plaque. Improving the quality of toothbrushing contributes to the mineralization of enamel. Polyvinylpyrrolidone is also a binder, thickener and adhesive agent, promotes the penetration of the components of the LPC into the teeth and periodontal tissue, which improves trophism.

Since diabetes causes damage to the soft tissues of the mouth, the LPC is designed for use without a toothbrush, namely in the form of foam. By consistency, the proposed LPC is a liquid with high foaming properties, which are provided by the presence of sodium lauryl sarcosinate (Crodasinic ™ LS95 PW). This well-known surface-active substance (surfactant) also has antibacterial, anti-caries properties (dissolves dental plaque) and increases the permeability of the oral mucosa for the active substances contained in the LPC. Compared to sodium lauryl sulfate, a surfactant widely used in other lipid peroxidants, sodium lauryl sarcosinate irritates the gums and oral membranes to a much lesser extent and overdries the oral mucosa. In the proposed LPK, these negative effects are minimized by the addition of the aforementioned allantoin. Sodium lauryl sarcosinate, unlike many other surfactants, is environmentally friendly, as it decomposes easily.

Foaming and penetration into the tissues of the components of the complex is facilitated by the Trilon B (Disodium EDTA) contained in it, a substance known as a complexing agent, pH regulator, emollient and chelating agent. Trilon B also has antioxidant preservative properties and acts synergistically with preservative ingredients, increasing their effectiveness. As such, LPK contains potassium sorbate and sodium methyl paraben. They belong to the class of food additives. The first of these compounds is a highly effective natural preservative, which is widely used in the food, cosmetic and pharmaceutical industries. The food additives mentioned also have antimicrobial properties; sodium methylparaben is an antiseptic.

To give a pleasant taste, a small amount of sodium saccharinate is introduced into the forest complex. The aforementioned xylitol, as a naturally formed sugar alcohol, is also a low-calorie sweetener - a healthy alternative to sugar. In this regard, the aforementioned stevia extract is superior to xylitol since stevia contains a compound that is hundreds of times sweeter than sugar but does not cause tooth decay.

Citric acid gives a characteristic pleasant taste of the wood complex. It has the properties of a sequestrant, and it regulates acidity, as does the sodium citrate contained in the LPC. This ingredient interacts with organic enamel substances, contributing to the creation of a protective barrier against tooth pain reactions to temperature and chemical stimuli (to hot, cold, sweet, acidic environments).

Well-known oils of mint, anise, cloves, cinnamon, marjoram, eucalyptus, fruit essences of mandarin, lemon, orange, various berry essences, etc. (The aforementioned kosfaderm is also a flavor).

To give the necessary viscosity, a water-soluble hydrogenated castor oil PEG-40 was introduced into the woodworking complex. Together with the used surfactant, it creates the necessary consistency of the wood-based complex, provides solubilizing, dispersing, emulsifying and wetting properties for other components.

LPC is prepared by mixing the components in the proportions corresponding to the invention. Water is poured into the reactor - in half of the final mass, heated to a temperature of 55-60 ° C and loaded, with continuous stirring, allantoin, potassium sorbate, xylitol, sodium methylparaben, sodium fluoride, sodium citrate, PEG-40, Trilon B. Then add the remaining half of the water and load the remaining components at a temperature of 35-40 ° C, constantly mixing the raw materials. The resulting homogeneous mass is allowed to settle and cool to room temperature. The process of preparing the timber industry takes about an hour.

The prepared mass is distributed among individual use cans with foaming and feeding devices for seasoned woodworking plants, as is known, for example, from RF patent No. 2423100. When using the spray can, the foamed mass - the foam envelops the teeth and gums, penetrating into places inaccessible when cleaning the oral cavity with a toothbrush with a paste. On wetted surfaces, the foam is well retained.

The LPC has been successfully tested for microbial purity. Toxicological tests showed the absence of an irritating effect of LIC on the mucous membranes of the oral cavity and gastrointestinal tract. Clinical trials of PPK have shown that it is safe for health and is an effective remedy for the complications inherent in diabetes (multiple caries, gum disease, susceptibility to fungal and other infections, bad breath).

The described properties of the timber complex are provided in the entire claimed range of the quantitative content of the components. For example, according to the invention, it is possible to prepare a LPC of such a specific composition, wt. %:

allantoin 0.1 flavoring 0.5 potassium sorbate 0.2 xylitol 15.0 lemon acid 0.1 sodium lauryl sarcosinate 0.8 sodium methylparaben 0.1 sodium saccharinate 0.1 sodium fluoride 0.1 sodium citrate 0.8 polyvinylpyrrolidone 4.0 PEG-40 2.0 Trilon B 0.1 Phytessence Stevia GL 2.0 Phytoliquid Fucus P 2.0 water 72.1

So, by creating the above-described LPK, the technical task claimed by the invention for obtaining the first LPK for caring for the oral cavity in diabetes mellitus has been solved. The technical result consists in obtaining this forestry complex.

All components of the proposed forestry complex are manufactured industrially and presented on the market, and technological methods for obtaining the composition are mastered.

The proposed LPK is recommended as an effective oral care product for diabetes. It is recommended to use LPK after each meal.

Claims (3)

1. Therapeutic and prophylactic composition for caring for the oral cavity in diabetes mellitus, characterized in that it contains allantoin, flavoring, potassium sorbate, xylitol, citric acid, sodium lauryl sarcosinate, sodium methyl paraben, sodium saccharin, sodium fluoride, sodium citrate, polyvinylpyrrolidone, PEG -40, Trilon B, Phytessence Stevia GL, Phytoliquid Fucus P and water, in the following proportions, wt. %:
allantoin 0.05-0.15 flavoring 0.4-0.6 potassium sorbate 0.1-0.3 xylitol 10.0-20.0 lemon acid 0.05-0.15 sodium lauryl sarcosinate 0.7-0.9 sodium methylparaben 0.05-0.15 sodium saccharinate 0.05-0.15 sodium fluoride 0.05-0.15 sodium citrate 0.7-0.9 polyvinylpyrrolidone 3.0-5.0 PEG-40 1.0-3.0 Trilon B 0.05-0.15 Phytessence Stevia GL 1.0-3.0 Phytoliquid Fucus P 1.0-3.0 water up to 100 2. The treatment and prophylactic composition according to claim 1, characterized in that it further comprises cosfaderm in an amount of 0.1-0.3% of the total mass. 3. The treatment and prophylactic composition according to claim 1, characterized in that it additionally contains Phytoliquid Rhatany in an amount of 1.0-3.0% of the total weight.