RU2574025C2 - Agent for treatment of acute gastrointestinal diseases of newborn lambs - Google Patents

Abstract

FIELD: veterinary medicine.

SUBSTANCE: preparation comprises in its structure the following components, wt %: sodium acetate - 45, flour of dried rhizome of leather bergenia Bergenia crassifolia - 25, dry extract of oak bark - 25, zinaprim - 2.5, metronidazole - 2.5.

EFFECT: invention facilitates rapid recovery of disorders of gastrointestinal tract, stimulates the body's natural resistance mechanism; the content of hemoglobin, red blood cells, white blood cells is significantly increased in the blood of animals under the influence of the agent, the level of bactericidal and lysozyme activity of blood serum is increased.

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Description

"The drug for the treatment of acute gastrointestinal diseases of newborn lambs" The invention relates to veterinary medicine, and in particular to means of treating acute gastrointestinal diseases of newborn lambs.

Acute gastrointestinal diseases of newborn lambs is one of the most common forms of pathology of young animals, which is observed in almost all farms involved in sheep farming. In many farms during the period of the brood company, which usually takes place in the winter-spring period of keeping animals, the acute gastrointestinal diseases of newborn lambs are in the nature of a real epizootic, affecting all nascent lambs. If no effective preventive and therapeutic measures are taken, the mortality among sick lambs reaches up to 60-80%.

Acute gastrointestinal diseases of newborn lambs include a large number of diseases that occur with signs of indigestion, and can be of infectious or non-infectious origin. They belong to intractable diseases, which is explained not only by their polyetiologicity, but also by the complexity of pathogenesis - they develop a disease of the whole organism, accompanied by a violation of the functions of almost all internal organs.

It should be noted that for the fight against acute gastrointestinal diseases of newborn lambs, a huge number of methods and tools have been proposed, especially for treatment. In recent years, more and more expensive imported drugs have been offered, but many farms are not able to purchase them because of the high cost.

No one doubts that the treatment of acute gastrointestinal diseases of newborn lambs can be successful with the use of a complex of drugs, and not just some “miraculous” monocomponent preparation. Success in treatment can be achieved by the simultaneous use of antimicrobial agents, anti-dehydration and intoxication agents that increase tone, normalize digestion, heal the intestinal mucosa, etc. The use of various means separately requires the implementation of many therapeutic procedures (injections and drinks) on each sick lamb. Therefore, veterinarians are physically unable to perform all procedures, especially with the massive nature of the disease, which is why they unwittingly simplify the treatment regimen, reducing the number of drugs or manipulations, thereby reducing its effectiveness.

The number of therapeutic manipulations is best reduced by the use of drugs in the form of complex preparations.

Of the combined analog preparations, startin, rehydraltan, eryprim, thromexin, radar and others are known. However, when using these drugs, a consistently high therapeutic effect is not always achieved due to the insufficient spectrum of their medicinal properties. In addition, their significant disadvantage is the high cost.

The closest technical solution, selected as a prototype of this invention, is the preparation Diaron, containing in its composition the zeolite of the Shivyrtuysky field - shivyrtuin, sodium acetate, rhizome of frankincense and tetracycline (patent No. 2381796). Diaron was used on the livestock of newborn lambs in a number of farms in the Trans-Baikal Territory.

However, the effectiveness of diaron when used in sheep breeding is low, since individual feeding of a medicinal suspension to newborn lambs is very laborious.

The aim of the present invention is to increase the effectiveness of the treatment of acute gastrointestinal diseases of newborn lambs while reducing its cost.

This goal is achieved in that the preparation contains the following components, wt.%:

Sodium Acetate - 45

Flour from the dried rhizome of a frankincense Bergenia crassifolia - 25

Dry Oak Bark Extract - 25

Zinaprim - 2.5

Metronidazole - 2.5.

Sodium acetate CH ₃ COONa - sodium salt of acetic acid, is produced and applied on an industrial scale, is a homogeneous crystals having a white color. Slight staining of sodium acetate from a grayish tint to pink is allowed, it is part of a number of drugs, it is used as a diuretic.

Rhizomes contain 15–27% of the gallotannins, which mainly belong to the group, in which the tannin content ranges from 8 to 10%. The content of arbutin in the leaves reaches 22%, and free hydroquinone - 4%, gallicellagic acid is also present. With age, the content of tannins in the rhizomes increases. Rhizomes contain isocoumarin, bergenin. By the content of arbutin, frankincense is the richest plant source. Badanas have hemostatic, astringent, anti-inflammatory and antimicrobial properties, strengthen the walls of blood vessels, moderately lower blood pressure, slightly increase the heart rate.

Oak (Latin Quercus) is a genus of trees and shrubs of the Beech family (Fagaceae). Composition of oak bark: starch, protein, sugar, flavonoids. About 20% are tannins. About 15% are pentosans, which have anti-inflammatory properties. And about 5% are pectins. Kehitin, this substance has the ability to destroy microbes. Oak bark has anti-inflammatory properties. It has oak bark disinfectant, bactericidal, astringent. Apply oak bark as an astringent for hemorrhoidal bleeding, as lotions and douching. Used for dysentery and diseases of the gastrointestinal tract. Oak bark contains a lot of tannic acid. Tannins have an astringent and anti-inflammatory effect, with diarrhea "fixing" the intestines.

Zinaprim is a yellowish-white powder for oral administration. The combination of sulfamethazine and trimethoprim included in the preparation has a synergistic effect and enhances each other by sequentially affecting the metabolism of para-aminobenzoic and folic acids in the microbial cell.

The drug provides a wide range of antimicrobial activity against gram-positive and gram-negative microorganisms: Escherichia coli, Clostridium spp., Salmonella spp., Proteus spp., Bacillus anthracis, Pasteurella spp., Haemophilus spp., Vibrio spp., Sppocococpt. , Shigella spp., Corynebacterium spp., Klebsiella spp., Fusobacterium spp., Bordetella spp.

Metronidazole * (Metronidazolum) metronidazole, 2- (2-methyl-5-nitro-1H-imidazol-1-yl) ethanol; basic physical and chemical properties: tablets of white or white with a yellowish-greenish tint.

Antibacterial, antiprotozoal (trichomonacid) agent. Derivative of nitroimidazole.

The mechanism of action is due to the penetration of the drug molecule into the microorganism, the incorporation of its nitro group into the respiratory chain of protozoa and anaerobes, which disrupts the respiratory processes and causes cell death. In some types of anaerobes, it inhibits DNA synthesis and causes its degradation (rupture of threads).

The spectrum of action includes the simplest: Trichomonas vaginalis, Entamoeba histolytica, Lamblia, Leishmania; anaerobic gram-negative microorganisms: bacteroids, including the Bacteroides fragilis group (B. fragilis, B. sassae, B. uniformis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus); Fusobacteria Prevotella (P. bivia, P. buccae, P. disiens); anaerobic gram-positive bacilli: Clostridium, sensitive strains of Eubacterium; anaerobic gram-positive cocci: Peptococcus spp., Peptostreptococcus spp. Trichomonacid action (death of about 99% of the above protozoa) is observed at a concentration of 2.5 μg / ml for 24 hours. For anaerobic microorganisms, the minimum bacteriostatic concentration causing 90% of their death is 8 μg / ml. Active against Mobiluncus, Mycoplasma hominis, protozoa Balantidium coli.

All components of the drug are powdery, easily mixed with each other, not scarce, not expensive, each of them has healing properties. In combined use, the healing properties of each component enhance the properties of the remaining components.

The drug does not require preliminary preparation before use, that is, it is immediately given to sick lambs in powder form.

Oak bark extract dry dietary supplement TU 9197-008-31474708-10

The rhizomes of badass thick-leaved (Bergenia crassifolia) are harvested in the autumn in the cedar forests of Transbaikalia, dried in the shade to a moisture content of not more than 14% and crushed using a crushing plant. Then turn into flour in special mills.

Sodium acetic acid, zinaprim, and metronidozole are acquired through the Zoovetsnab system and other organizations selling veterinary drugs.

The components sifted through a sieve are placed in the required proportions in an enameled container and mixed with wooden spatulas. Then the resulting mixture is stirred in an electric mixer for 20 minutes until a homogeneous powder is obtained. A dosage form in the form of a brown powder is packaged in 0.5 kg plastic bags.

Specific Impact Examples

Example 1. When using the drug was used with a minimum ratio of the main ingredients.

Wt.%: Sodium acetate - 45; flour from the dried rhizome of frankincense Bergenia crassifolia - 25, dry oak bark extract - 25, zinaprim - 2.5 and metronidazole - 2.5

The test of the therapeutic effectiveness of gastropulvin was carried out under industrial conditions on flocks during the period of the brood company in AKF them. Lenin »of the Mogoytuysky district of the Transbaikal Territory. The experiment was carried out on newborn lambs with pronounced clinical signs of a gastrointestinal disease. By the principle of analogues, they were divided into two groups - the experimental and control 50 goals in each in the following order: the first sick lamb was included in the experimental group, the second in the control, the third in the experimental, the fourth in the control, etc.

The experimental lambs were treated with the drug at a dose of 5 g per head. The drug was administered twice a day with an interval of about 12 hours.

Control lambs were treated with diarone as instructed. The following indicators were taken into account: the duration of the disease, the nature of its course during the treatment period, the frequency of drug administration, and the outcome of the disease.

In the experimental group, 72% of the lambs recovered after a double dose of the drug, 18% - after a triple, 10% - a quadruple. The therapeutic effectiveness of the drug was 100%. And in the control group 2 lamb fell, the rest recovered in the period from 48 to 72 hours. The therapeutic efficacy of diarone was 96%.

Example 2. When using the drug was used in average ratios of the main ingredients

Wt.%: Sodium acetate - 35; flour from the dried rhizome of frankincense Bergenia crassifolia - 30, dry oak bark extract - 30, zinaprim - 2.5 and metronidazole - 2.5

The design of the experiment was similar to that in the first experiment. The duration of the disease in the lambs of the experimental group ranged from 48 to 72 hours, the treatment efficiency was 100%, and in the control lambs, respectively, from 48 to 72 hours and 96%.

Example 3. When using the drug was used in ratios of the main ingredients

Wt.%: Sodium acetate - 55; flour from the dried rhizome of frankincense Bergenia crassifolia - 20, dry oak bark extract - 20, zinaprim - 2.5 and metronidazole - 2.5

The experiment was carried out according to the same methodology as in previous experiments. The duration of the disease in the lambs of the experimental group ranged from 48 to 72 hours, the treatment efficiency was 100%, and in the control lambs, respectively, from 48 to 72 hours and 96%.

Thus, the experiments showed high efficacy of the drug in different ratios of the main ingredients in acute gastrointestinal diseases of newborn lambs.

In all experiments, all the lambs that were treated with the drug recovered. Slight differences in the results depended on the ratio of the ingredients in the preparation and the dose. The disease was cured within 2 days after giving the drug from 2 to 4 times. The treatment efficiency was 100% in all experiments.

Among the control lambs, mortality was observed, the duration of the disease ranged from 4 to 6 days. All experimental lambs were ill in mild form, and control ones in severe and moderate forms.

Claims (1)

A drug for the treatment of acute gastrointestinal diseases of newborn lambs, containing the following components, wt.%:
Sodium Acetate 45 Flour from dried incense rhizome Plate Bergenia crassifolia 25 Dry Oak Bark Extract 25 Zinaprim 2,5 Metronidazole 2,5