RU2553625C2 - Ester-oil composition 'bioprotection' for treating asthenic syndrome in patients with dyscirculatory encephalopathy - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the pharmaceutical industry, particularly to a composition for treating asthenic syndrome in patients with dyscirculatory encephalopathy. An ester-oil composition for treating asthenic syndrome in the patients with dyscirculatory encephalopathy contains eucalyptus, mint, pine, cedar, lavender, carnation, flax essences taken in certain relations.

EFFECT: composition is effective for treating asthenic syndrome in the patients with dyscirculatory encephalopathy; it causes the selective harmonising action on the central nervous system, regulates the emotional status, improves cognitive functions, reduces clinical manifestations of asthenic syndrome considerably and improves the quality of life in the patients with dyscirculatory encephalopathy.

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Description

The invention relates to medicine, specifically to the creation of herbal medicines for the treatment of discirculatory encephalopathy (DE).

The problem of chronic progressive vascular diseases of the brain is advanced to one of the leading places in modern angioneurology. In recent years, there has been an increase in the number of patients with vascular diseases of the brain. DE belong to free-radical pathology, which highlights the processes of lipid peroxidation in the pathogenesis of the disease. The system of protection against the damaging effects of reactive oxygen species and products of their interaction with the main substrates for peroxidation of polyunsaturated fatty acids includes a number of enzyme systems (superoxide dismutase, catalase, glutathione peroxidase, etc.), localized in the places of accumulation of active intermediates. In addition, non-enzymatic antioxidants are present in the hydrophilic and hydrophobic phases of the cell, among which ascorbate, a-tocopherol, glutathione, carotenoids, flavonoids and polyphenolic compounds take a leading place (Pospelova M.L. Use of medicinal properties of spices in traditional medical systems / O. D. Barnaulov, M.L. Pospelova, M.A. Zaitseva // Integrative medicine 2010: Materials of the international forum.- M., 2010. - P.159-160; Pospelova, M.L. Content of markers of endothelial dysfunction in patients with varying severity a herosclerosis of the bracheocephalic arteries / M.L. Pospelova, O.D. Barnaulov, O.Yu. Matvienko et al. // Man and Medicine: Materials of the XVII Russian National Congregation - M., 2010. - P.223-224 ; Pospelova, M.L. Markers of inflammation in atherosclerosis, activity of the fibrinolysis system in patients with symptomatic and asymptomatic atherosclerosis of the bracheocephalic arteries / M.L. Pospelova, O.D. Barnaulov, T.V. Osipova // Systemic circulation, hemorheology and microcirculation: Materials VIII int. conf. - Yaroslavl, 2011 .-- P.73). A large place in the clinical picture of DE is occupied by emotional and personality disorders. At the initial stages of the disease, they are represented by an asthenic symptom complex with predominantly hypersthenic manifestations - irritability, poor sleep, distraction, loss of attention, headache, sensation of noise in the head. Modern methods of treating DE with drugs do not solve the problem of asthenic disorders. Long-term use of pharmacological agents reduces their effectiveness, contributes to the development of complications and the appointment of new medicines. Adaptogens became the first drugs in the world practice for the treatment of asthenia, the mechanism of which is realized by increasing the synthesis of dopamine, such as preparations of ginseng, Manchurian aralia, Golden root (Rhodiola rosea), safflower left-handed (Maralis root), Schisandra lemongrass, platifolia leaves, Eleuthera high zamani, pantocrine (Georgievsky V.P., Komissarenko N.F., Dmitruk S.E. Biologically active substances of medicinal plants. - Novosibirsk: Science. - 333 p .; Clinical Pharmacology. V.G. Kukes. - Mo Squat. - Geotar-medicine. - 1999. - 526 p.).

Hydroaeroionotherapy is used as an independent method and in combination with other types of physiotherapy and drugs. It is advisable to prescribe oxygen therapy in the form of oxygen cocktails, which has a general stimulating effect and improves the state of the nervous system. The combination of aeroionotherapy and oxygen therapy gives a good clinical effect: health, memory, headaches disappear, vestibular and emotional-volitional disorders decrease. A known method of training therapy with intermittent hypoxic exposure by inhalation of an air-nitrogen mixture containing 10% oxygen (Neretin V.Ya. Combined therapy of chronic brain ischemia. - M., 2002). Procedures for the combined effects of light, aromatic oils, heat, massage, music and aeroionized air have become new in the treatment of DE. (Rybkin V.M., Bragar A.S., Maslova I.N., Smolskaya O.E. Complex rehabilitation of patients with discirculatory encephalopathy / Rehabilitation and physiotherapy. 2008. - No. 6). In the literature there is evidence of the successful use of acupuncture and herbal medicine (Morozova O.G., Zdybsky V.I., Yaroshevsky A.A. Restorative treatment of chronic cerebral ischemia using reflexotherapy and oriental herbal medicine // International Neurological Journal, 2010. - 8 (38)). Gingko biloba leaf extract has a non-specific antihypoxic effect on the tissues of the whole body, including at the level of neurons. It affects the neurotransmitter transsynaptic transmission, affects the release, reabsorption and breakdown of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to bind to membrane receptors. The flavonoids contained in the preparations bind free radicals and neutralize their destructive effect (Gromova O.A., Burtsev E.M., Limanova O.A. Features of the structural spectrum of a standardized Ginkgo biloba extract by the example of bilobil and its antioxidant activity // Free Radicals and Diseases person. - Smolensk, 1999. - P.52-56; Chandrasekaran K., Mehrabian Z., Spinnewyn B. Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death // Pharmacopsychiatry. - 2003. - Vol. 36, No. 1. - P.89-94). Inhalation of stimulating aromas of peppermint, rosemary, b Azilica not only led to a clinically pronounced increase in mental activity, manifested in a more precise implementation of the assigned intellectual tasks, but was also accompanied by an increase in the number of beta waves, in contrast to the control group, where this was not observed. When inhaling soothing aromas of valerian, lavender, on the contrary, an increase in the number of alpha, theta and delta waves was noted. The positive effect of biologically active substances of plants on cerebral circulation has been proven by L.S. Leshchinsky et al. (Soldatchenko S.S., Kashchenko G.F. Prevention and treatment of diseases with essential oils. - Stavropol, 1998. - 144 p.). L.G. Dudchenko reports on the effective use of aromatherapy in patients with hypertension, when in parallel with the hypotensive effect, essential oils had a beneficial effect on general clinical indicators: headache, tinnitus, dizziness. (Dudchenko L.G. Health flavors (treatment with essential oil plants and essential oils) / Edited by candidate of medical sciences VV Krivenko. - Kiev: Globus, 1997. - 150 p.) It was also established that aromatherapy is effective it is possible not only during a person’s wakefulness, but also during sleep, which is confirmed by distinct electroencephalographic changes, dynamics of the heart rate, blood pressure, and electrocardiographic indicators. It has been clinically proven that even inhaling the aroma of an apple can weaken the pathogenic effects of stress and normalize blood pressure. Clinical experiments and scientific studies have proved the high therapeutic efficacy of biologically active substances of plants, which in some cases is superior to medicines. So, the aroma of lavender, chamomile, lemon, sandalwood can reduce brain activity faster than a number of depressants. And jasmine, rose, mint and cloves excite gray matter cells more powerful than the therapeutic dose of caffeine (Soldatenko S.S., Nikolaevsky V.V. Essential oils. The oldest therapeutic agent. - http://Linkz.Ru. - 2004). It should be noted that the herbal formula is compiled empirically, based on the preferences and experience of the doctor. Almost no standardized phytocompositions.

According to the literature, the authors did not find a unified approach to the treatment of asthenic syndrome with DE according to the literature. Aromatherapy is rarely used unjustifiably, the selection of herbs is carried out empirically, there are no standardized phytocompositions. Analogs of the invention can be "Antisept" company "Aromafarm" (oil kaeputa, naioli, ravensara, tea tree, eucalyptus); "Ingalar" Corporation "Arterium" (eucalyptus oil, peppermint, fir, turpentine).

The technical result of the proposed method is to create the optimal complex of oils of eucalyptus, pine, cedar, mint, lavender and cloves, which has the maximum effectiveness in treating asthenic syndrome in DE by conducting a patient with asthenic syndrome in DE of essential oil-inhalation phyto-composition "Bioprotection" containing 100 ml of eucalyptus oil 3.5 g, pine - 2.5 g, cedar - 2.5 g, mint - 3.5 g, lavender - 2.5 g, cloves - 0.5 g, base linseed oil up to 100 ml. The course of treatment consists of ten procedures. The first lasts 5 minutes (3 drops of aromatic mixture), 2 and 3 procedures for 6 minutes (4 drops), 4 and 5 procedures for 7 minutes (5 drops), 6 and 7 procedures for 8 minutes (5 drops), 8 and 9 procedures 9 minutes (5 drops), 10 procedures - 10 minutes (5 drops).

The study of the effectiveness of aromatherapy in 78 patients with asthenic syndrome with DE (mean age 45.4 + 11.2 years) was conducted, the control group consisted of 38 patients of similar age who received standard therapy.

The proposed composition is prepared as follows: 3.5 g of eucalyptus oil, pine 2.5 g, cedar 2.5 g, mint 3.5 g, lavender 2.5 g, cloves 0, 5 g. The mixture is brought to a volume of 100 ml with linseed oil. Mixing the components is done by shaking. Inhalations were carried out in the physiotherapy center of the City Polyclinic No. 5 OBUZ in Ivanovo every day for 15 minutes with the TAKIO YH 1502 inhaler device. The device is equipped with a steam inhaler, a nozzle for inhalation and a nebulizer.

As performance criteria, we used the dynamics of clinical indicators, neuropsychological tests (short-term memory according to the tests “Memory for numbers”, “Memory for images”, attention according to the tables “Schulte”), psychoemotional status (test “Spielberg-Khanin”, multi-factor SMOL questionnaire) , dynamics of quality of life according to the test "Health Status Survey" ("SF-36"). The study of cerebral blood flow according to rheoencephalography and bioelectric activity of the brain using electroencephalography was carried out on the neurophysiological complex "Neuron Spectrum" (Ivanovo).

Statistical processing of the results was carried out using the methods of parametric and nonparametric statistics on a personal computer using the Statistica 6.0 program with the determination of mean values (M), mean error (m), Student-Fisher reliability criterion (t), significance level (p), homogeneity criterion χ ² . The differences were considered significant at p <0.05 or χ ² > 3.8.

When studying clinical symptoms during aromatherapy, the main group showed the most pronounced positive dynamics: headache intensity decreased in 64.4% (p <0.05) patients, noise in the head - in 24.5% (p <0.05) , dizziness, sleep disturbances, decreased memory and attention by 31.1; 46.7 and 44.5%, respectively (p <0.05 in all cases). The control group also showed positive dynamics, but it was significantly lower than in the main group.

After the course of aromatherapy, the average time spent searching for numbers by the Schulte test decreased in the main group by 24.2% (p <0.05). The control group also showed positive dynamics, but it was significantly lower than in the main group.

After the treatment, there was an increase in the speed characteristics of blood flow by 10% in the first group. The positive effect of the therapy was reflected in the trend towards normalization of the basic EEG rhythms. In patients with treatment, an increase in the total spectrum of alpha activity (mainly in the frontal and temporal regions), beta-1 activity (mainly in the central region) and beta-2 activity (mostly in the temporal and central regions) was recorded. The average value of the total spectrum of theta and delta activity decreased during treatment. The greatest dynamics were recorded in the temporal, parietal and frontal lobes.

Example 1. Patient N., 45 years old. Suffers from hypertension for 10 years. During the year, notes irritability, decreased sleep, distraction, loss of attention, headache, sensation of noise in the head. In neurological status, mild symptoms of oral automatism, asymmetry of abdominal and tendon reflexes, and mild coordination disorders are detected. The background recording of the EEG is characterized by a decrease in the amplitude of the alpha rhythm (54 μV) and its disorganization. The oscillation frequency is 8.5 Hz. The beta rhythm does not have a clear topical characteristic. Periodically recorded slow waves of the delta, theta range with an amplitude of up to 30 μV in the parietal leads of the right hemisphere. According to the REG data, signs of angioedema, a decrease in pulse blood supply, and mild venous dyshemia were revealed. On the basis of complaints, medical history and neurological symptoms, the patient was diagnosed with stage I of DE, characterized by asthenia with predominantly hypersthenic manifestations. A course of aromatherapy was carried out in the form of daily inhalations with the “Bioprotection” essential oil composition according to a treatment regimen consisting of ten procedures. The first lasts 5 minutes (3 drops of aromatic mixture), 2 and 3 procedures for 6 minutes (4 drops), 4 and 5 procedures for 7 minutes (5 drops), 6 and 7 procedures for 8 minutes (5 drops), 8 and 9 procedures 9 minutes (5 drops), 10 procedures - 10 minutes (5 drops) on a Sauna apparatus TAKIO YH 1502 inhaler. As a result of treatment, an improvement in attention, a decrease in the frequency and a decrease in headache intensity, and normalization of sleep were noted.

Dynamics of indicators of neuropsychological tests in patients with DE in the studied groups before and after treatment (M ± m) Tests Patients with DE The main group (n = 78) Control Group (n = 38) The average number of memorized images by the test "Memory for images"

$$\frac{7.1\pm 0.5}{10.6\pm 0.4*}$$

The average number of memorized numbers in the test "Memory for numbers" $$\frac{5.2\pm 0.5}{9.1\pm 0.4*}$$

Claims (1)

Essential oil composition for the treatment of asthenic syndrome in patients with discirculatory encephalopathy, containing oils of eucalyptus, peppermint, pine, cedar, lavender, clove, flax in the following ratio of components:
eucalyptus oil 3.5 g peppermint oil 3.5 g pine oil 2.5 g cedar oil 2.5 g lavender oil 2.5 g clove oil 0.5 g flax oil up to 100 ml