RU2548673C3 - Фармацевтическая композиция, содержащая производное хинолина - Google Patents
Фармацевтическая композиция, содержащая производное хинолинаInfo
- Publication number
- RU2548673C3 RU2548673C3 RU2012103471A RU2012103471A RU2548673C3 RU 2548673 C3 RU2548673 C3 RU 2548673C3 RU 2012103471 A RU2012103471 A RU 2012103471A RU 2012103471 A RU2012103471 A RU 2012103471A RU 2548673 C3 RU2548673 C3 RU 2548673C3
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition containing
- formula
- compound represented
- quinoline derivative
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- HWLFIUUAYLEFCT-UHFFFAOYSA-N lenvatinib mesylate Chemical compound CS(O)(=O)=O.C=12C=C(C(N)=O)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC1CC1 HWLFIUUAYLEFCT-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (9)
1. Фармацевтическая композиция, содержащая
(1) соединение, представленное формулой (I), или его фармацевтически приемлемую соль или сольват:
где R1 представляет собой циклопропильную группу; a R2 представляет собой атом водорода; и
(2) карбонат кальция, где содержание соединения, представленного формулой (I), или его соли или сольвата составляет от 4,0 до 12,25 мас.%, и содержание карбоната кальция составляет от 10 до 40 мас.% относительно общей массы композиции соответственно.
2. Композиция по п.1, где R1 представляет собой циклопропильную группу, и R2 представляет собой атом водорода.
3. Композиция по п. 1, где фармацевтически приемлемая соль представляет собой метансульфонат.
4. Композиция по п.1, где соединение, представленное формулой (I), представляет собой метансульфонат 4-(3-хлор-4-(циклопропиламинокарбонил)аминофенокси)-7-метокси-6-хинолинкарбоксамида.
5. Композиция по п.1, дополнительно содержащая гидроксипропилцеллюлозу с низкой степенью замещения.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012103471A RU2548673C3 (ru) | 2009-08-19 | 2010-08-16 | Фармацевтическая композиция, содержащая производное хинолина |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009-190145 | 2009-08-19 | ||
| JP2009190145 | 2009-08-19 | ||
| RU2012103471A RU2548673C3 (ru) | 2009-08-19 | 2010-08-16 | Фармацевтическая композиция, содержащая производное хинолина |
| PCT/JP2010/063804 WO2011021597A1 (ja) | 2009-08-19 | 2010-08-16 | キノリン誘導体含有医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2012103471A RU2012103471A (ru) | 2013-09-27 |
| RU2548673C2 RU2548673C2 (ru) | 2015-04-20 |
| RU2548673C3 true RU2548673C3 (ru) | 2018-07-20 |
Family
ID=43607048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012103471A RU2548673C3 (ru) | 2009-08-19 | 2010-08-16 | Фармацевтическая композиция, содержащая производное хинолина |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20120077842A1 (ru) |
| EP (1) | EP2468281B1 (ru) |
| JP (1) | JP5048871B2 (ru) |
| KR (1) | KR101496395B1 (ru) |
| CN (1) | CN102470133B (ru) |
| AU (1) | AU2010285740C1 (ru) |
| BR (1) | BR112012003592B8 (ru) |
| CA (1) | CA2771403C (ru) |
| CL (1) | CL2012000412A1 (ru) |
| CO (1) | CO6440512A2 (ru) |
| CY (1) | CY1117481T1 (ru) |
| DK (1) | DK2468281T3 (ru) |
| ES (1) | ES2564797T3 (ru) |
| HR (1) | HRP20160283T1 (ru) |
| HU (1) | HUE026957T2 (ru) |
| IL (1) | IL217197A (ru) |
| MA (1) | MA33581B1 (ru) |
| ME (1) | ME02359B (ru) |
| MX (2) | MX344927B (ru) |
| MY (1) | MY162940A (ru) |
| NZ (1) | NZ598291A (ru) |
| PE (1) | PE20121030A1 (ru) |
| PL (1) | PL2468281T3 (ru) |
| RS (1) | RS54686B1 (ru) |
| RU (1) | RU2548673C3 (ru) |
| SG (1) | SG178009A1 (ru) |
| SI (1) | SI2468281T1 (ru) |
| SM (1) | SMT201600077B (ru) |
| TH (1) | TH121482A (ru) |
| UA (1) | UA105671C2 (ru) |
| WO (1) | WO2011021597A1 (ru) |
| ZA (1) | ZA201108697B (ru) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006030826A1 (ja) | 2004-09-17 | 2006-03-23 | Eisai R & D Management Co., Ltd. | 医薬組成物 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| CN101277720A (zh) * | 2005-09-01 | 2008-10-01 | 卫材R&D管理有限公司 | 崩解性被改善的药物组合物的制备方法 |
| WO2007052849A1 (ja) | 2005-11-07 | 2007-05-10 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質とc-kitキナーゼ阻害物質との併用 |
| CA2652442C (en) * | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Antitumor agent for thyroid cancer |
| KR101472600B1 (ko) * | 2006-08-28 | 2014-12-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 미분화형 위암에 대한 항종양제 |
| CN101600694A (zh) | 2007-01-29 | 2009-12-09 | 卫材R&D管理有限公司 | 未分化型胃癌治疗用组合物 |
| WO2009060945A1 (ja) * | 2007-11-09 | 2009-05-14 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質と抗腫瘍性白金錯体との併用 |
| CA2802644C (en) | 2010-06-25 | 2017-02-21 | Eisai R & D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
| CA2828946C (en) | 2011-04-18 | 2016-06-21 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| MX2015004979A (es) | 2012-12-21 | 2015-07-17 | Eisai R&D Man Co Ltd | Forma amorfa de derivado de quinolina y metodo para su produccion. |
| SG11201509278XA (en) | 2013-05-14 | 2015-12-30 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| IL302218B2 (en) | 2014-08-28 | 2024-10-01 | Eisai R&D Man Co Ltd | Methods for manufacturing high-purity lenvatinib and its derivatives |
| CN106139156B (zh) * | 2014-11-14 | 2019-01-29 | 江苏恒瑞医药股份有限公司 | 一种含有喹啉衍生物或其盐的药物组合物 |
| JP6792546B2 (ja) * | 2015-02-25 | 2020-11-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | キノリン誘導体の苦味抑制方法 |
| AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
| CN106075456A (zh) * | 2015-04-27 | 2016-11-09 | 南京圣和药业股份有限公司 | 一种含乐伐替尼的药物组合物及其应用 |
| EP3287444A4 (en) * | 2015-05-21 | 2018-09-12 | Crystal Pharmatech Co., Ltd. | New crystal form of lenvatinib methanesulfonate salt and preparation method thereof |
| EP3311841B1 (en) | 2015-06-16 | 2021-07-28 | PRISM BioLab Co., Ltd. | Anticancer agent |
| CN106999483B (zh) * | 2015-08-17 | 2019-05-03 | 江苏恒瑞医药股份有限公司 | 一种含有喹啉衍生物或其盐的药物组合物 |
| CN108135894B (zh) | 2015-08-20 | 2021-02-19 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
| RU2606592C1 (ru) * | 2015-10-07 | 2017-01-10 | Открытое Акционерное Общество "Татхимфармпрепараты" | Фармацевтическая композиция, содержащая кальциевую соль розувастатина (варианты) |
| CZ2016240A3 (cs) | 2016-04-27 | 2017-11-08 | Zentiva, K.S. | Soli lenvatinibu |
| RU2750539C2 (ru) | 2017-02-08 | 2021-06-29 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Фармацевтическая композиция для лечения опухоли |
| EP3384901B1 (en) * | 2017-04-04 | 2024-08-14 | Synthon B.V. | Pharmaceutical composition comprising lenvatinib mesylate |
| AU2018269996A1 (en) | 2017-05-16 | 2019-11-21 | Eisai R&D Management Co., Ltd. | Treatment of hepatocellular carcinoma |
| US10583133B2 (en) | 2018-03-12 | 2020-03-10 | Shilpa Medicare Limited | Pharmaceutical compositions of lenvatinib |
| CN110404079B (zh) * | 2018-04-27 | 2023-01-24 | 北京睿创康泰医药研究院有限公司 | 一种不含碳酸盐、低基因毒性杂质含量的喹啉衍生物或其盐的药物组合物 |
| ES2970132T3 (es) | 2018-10-04 | 2024-05-27 | Synthon Bv | Composición farmacéutica que comprende besilato de lenvatinib |
| EP3632436B1 (en) | 2018-10-04 | 2022-04-20 | Synthon B.V. | Pharmaceutical composition comprising lenvatinib salts |
| CN113087666B (zh) * | 2020-01-09 | 2021-12-14 | 南京正大天晴制药有限公司 | 无定形喹啉甲酰胺衍生物的制备方法 |
| CN113491695A (zh) * | 2020-03-18 | 2021-10-12 | 上海博志研新药物技术有限公司 | 一种仑伐替尼药物组合物、其制备方法及应用 |
| EP4147689A1 (en) | 2021-09-13 | 2023-03-15 | Lotus Pharmaceutical Co., Ltd. | Lenvatinib formulation |
| CN114306271B (zh) * | 2021-11-24 | 2023-04-07 | 石药集团中奇制药技术（石家庄）有限公司 | 一种仑伐替尼组合物 |
| CN115671074B (zh) * | 2022-11-15 | 2024-06-04 | 郑州德迈药业有限公司 | 一种甲磺酸仑伐替尼制剂及其制备方法 |
| EP4424303A1 (en) | 2023-02-28 | 2024-09-04 | Stada Arzneimittel Ag | Lenvatinib composition with improved bioavailability |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1458148A (en) * | 1974-04-19 | 1976-12-08 | Wyeth John & Brother Ltd | Carbocyclic-fused ring quinoline derivatives |
| US5009894A (en) * | 1988-03-07 | 1991-04-23 | Baker Cummins Pharmaceuticals, Inc. | Arrangement for and method of administering a pharmaceutical preparation |
| WO2002032872A1 (fr) * | 2000-10-20 | 2002-04-25 | Eisai Co., Ltd. | Composes a noyau aromatique azote |
| AU2003273000A1 (en) * | 2002-10-16 | 2004-05-04 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
| JP4749660B2 (ja) * | 2002-10-16 | 2011-08-17 | 武田薬品工業株式会社 | 安定な固形製剤 |
| WO2004035543A1 (en) * | 2002-10-21 | 2004-04-29 | Warner-Lambert Company Llc | Tetrahydroquinoline derivatives as crth2 antagonists |
| ATE508747T1 (de) * | 2003-03-10 | 2011-05-15 | Eisai R&D Man Co Ltd | C-kit kinase-hemmer |
| PL1698623T3 (pl) * | 2003-12-25 | 2015-08-31 | Eisai R&D Man Co Ltd | Postać krystaliczna soli 4-(3-chloro-4-(cyklopropyloaminokarbonylo)aminofenoksy)-7-metoksy-6-chinolinokarboksamidu lub jej solwatu i sposoby ich wytwarzania |
| WO2006030826A1 (ja) * | 2004-09-17 | 2006-03-23 | Eisai R & D Management Co., Ltd. | 医薬組成物 |
| KR100951607B1 (ko) * | 2005-06-23 | 2010-04-09 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 4-(3-클로로-4-(시클로프로필아미노카르보닐)아미노페녹시)-7-메톡시-6-퀴놀린카르복사미드의 비정질 염 및 그 제조방법 |
| US7550483B2 (en) * | 2005-06-23 | 2009-06-23 | Eisai R&D Management Co., Ltd. | Amorphous salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and process for preparing the same |
| AR059066A1 (es) * | 2006-01-27 | 2008-03-12 | Amgen Inc | Combinaciones del inhibidor de la angiopoyetina -2 (ang2) y el inhibidor del factor de crecimiento endotelial vascular (vegf) |
| EP2259844A4 (en) * | 2008-03-05 | 2012-02-01 | Vicus Therapeutics Llc | COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGICAL THERAPIES |
-
2010
- 2010-08-16 US US13/322,961 patent/US20120077842A1/en not_active Abandoned
- 2010-08-16 CN CN2010800305086A patent/CN102470133B/zh not_active Ceased
- 2010-08-16 AU AU2010285740A patent/AU2010285740C1/en active Active
- 2010-08-16 KR KR1020127003846A patent/KR101496395B1/ko active Active
- 2010-08-16 CA CA2771403A patent/CA2771403C/en active Active
- 2010-08-16 HU HUE10809938A patent/HUE026957T2/en unknown
- 2010-08-16 BR BR112012003592A patent/BR112012003592B8/pt active IP Right Grant
- 2010-08-16 SI SI201031141A patent/SI2468281T1/sl unknown
- 2010-08-16 MX MX2014010594A patent/MX344927B/es unknown
- 2010-08-16 SG SG2011086022A patent/SG178009A1/en unknown
- 2010-08-16 ME MEP-2016-45A patent/ME02359B/me unknown
- 2010-08-16 NZ NZ598291A patent/NZ598291A/xx unknown
- 2010-08-16 UA UAA201203132A patent/UA105671C2/ru unknown
- 2010-08-16 RS RS20160176A patent/RS54686B1/sr unknown
- 2010-08-16 HR HRP20160283TT patent/HRP20160283T1/hr unknown
- 2010-08-16 TH TH1001000221A patent/TH121482A/th unknown
- 2010-08-16 MY MYPI2011700172A patent/MY162940A/en unknown
- 2010-08-16 JP JP2011527665A patent/JP5048871B2/ja active Active
- 2010-08-16 MX MX2012002011A patent/MX2012002011A/es unknown
- 2010-08-16 DK DK10809938.3T patent/DK2468281T3/en active
- 2010-08-16 WO PCT/JP2010/063804 patent/WO2011021597A1/ja not_active Ceased
- 2010-08-16 PE PE2011002081A patent/PE20121030A1/es active IP Right Grant
- 2010-08-16 ES ES10809938.3T patent/ES2564797T3/es active Active
- 2010-08-16 PL PL10809938T patent/PL2468281T3/pl unknown
- 2010-08-16 EP EP10809938.3A patent/EP2468281B1/en active Active
- 2010-08-16 RU RU2012103471A patent/RU2548673C3/ru active Protection Beyond IP Right Term
-
2011
- 2011-11-25 ZA ZA2011/08697A patent/ZA201108697B/en unknown
- 2011-12-25 IL IL217197A patent/IL217197A/en active IP Right Grant
-
2012
- 2012-02-09 CO CO12022608A patent/CO6440512A2/es not_active Application Discontinuation
- 2012-02-16 CL CL2012000412A patent/CL2012000412A1/es unknown
- 2012-03-12 MA MA34683A patent/MA33581B1/fr unknown
-
2013
- 2013-06-21 US US13/923,858 patent/US20130296365A1/en not_active Abandoned
-
2016
- 2016-03-17 SM SM201600077T patent/SMT201600077B/xx unknown
- 2016-04-05 CY CY20161100273T patent/CY1117481T1/el unknown
-
2021
- 2021-04-12 US US17/228,025 patent/US20210228722A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2548673C3 (ru) | Фармацевтическая композиция, содержащая производное хинолина | |
| WO2009016460A3 (en) | Pyrazole compounds and their use as raf inhibitors | |
| RU2010145171A (ru) | Аналоги галихондрина в | |
| RU2582676C3 (ru) | Некоторые химические соединения, композиции и способы | |
| JP2009533369A5 (ru) | ||
| JP2016540742A5 (ru) | ||
| MX2010003001A (es) | Derivados de quinolina como antagonistas del receptor de la 5-hidroxitriptamina 5a. | |
| NO20063748L (no) | Kinolinderivater og anvendelse derav som mykobakterielle inhibitorer | |
| RU2014123567A (ru) | Кристаллическая 7{(3s, 4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил}-6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1, 4-дигидрохинолин-3-карбоновая кислота | |
| EA201201033A1 (ru) | Циклический амин и акарицид | |
| RU2017102513A (ru) | Соль гетероциклического соединения, замещенного галогеном | |
| MX2010001576A (es) | Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6). | |
| CY1112011T1 (el) | Παραγωγα αζαδικυκλο (3.1.0) εξανιου χρησιμα ως ρυθμιστες υποδοχεων d3 ντοπαμινης | |
| EA200701745A1 (ru) | Циклопропанкарбоксамидные производные | |
| UY30842A1 (es) | Derivados de n-(amino-heteroaril)-1h-pirrolopiridin-2-carboxamidas, su preparacion y su aplicacion en terapéutica | |
| MX369956B (es) | Metodos para preparar compuestos de benzoquinolina. | |
| EA200900707A1 (ru) | Новый способ синтеза 7,8-диметокси-1,3-дигидро-2h-3-бензазепин-2-она, и его применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой | |
| EA201500575A1 (ru) | Транс-4-{2-[4-(2,3-дихлорфенил)пиперазин-1-ил]этил}-n,n-диметилкарбамоилциклогексиламин для лечения негативных симптомов шизофрении | |
| AR076362A1 (es) | Arilsulfonamidas 2,5-disustituidas antagonistas de ccr3, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento y/o prevencion de patologias autoinmunes e inflamatorias, entre otras. | |
| WO2012024397A3 (en) | 2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin | |
| EA201270653A1 (ru) | Антагонист dpи его применение | |
| PE20091735A1 (es) | Derivados del acido 4-dimetilaminobutirico | |
| NO20090646L (no) | Xinafoatsalt av en substituert 5-oksazol-2-yl-kinolinforbindelse | |
| EA200702612A1 (ru) | Соединения бензимидазолкарбоксамида в качестве агонистов рецепторов 5-нт | |
| WO2014195593A3 (fr) | Composes inhibiteurs de l'acetylcholinesterase et agonistes des recepteurs serotoninergiques 5ht4, a effet promnesiant, leurs procedes de preparation et compositions pharmaceutiques les contenant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ND4A | Extension of patent duration |
Effective date: 20180720 |