RU2438688C1 - Anti-helminth medication of vegetable origin - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of pharmaceutical medications, in particular, to anti-helminth medications based on therapeutic vegetable raw material. Anti-helminth medication, made in accordance with the claimed invention, contains extract of absinthe usual or wormwood, powder of tansy flowers, powder of clove buds, extract of milk thistle, powder of ginger root and powder of garlic with defined component ratio.

EFFECT: medication extends spectrum of therapeutic-preventive impacts on organism and increases patient convenience during treatment course.

5 cl, 1 tbl

Description

The invention relates to the field of pharmaceuticals, in particular to anthelmintic preparations based on medicinal plant materials.

The pharmaceutical market today has a number of potent synthetic drugs to combat helminthic invasions. The main disadvantages of such anthelmintic drugs are their toxicity, a large number of side effects and high cost.

Interest in herbal preparations is due to their naturalness, low toxicity, and better tolerance. Plants are used to treat parasitic diseases from ancient times. However, researchers are still creating new drugs, varying the quantitative and component composition of plant materials. Known antiparasitic tincture according to the patent of the Russian Federation No. 2182012, which is a tincture of the pericarp of a biologically ripe walnut. Tincture is obtained in the following ratio of components, wt.%: Pericarp of ripe walnut - 4-6%; ethanol solution 94-96%.

The drug according to the patent of the Russian Federation No. 2132693 is prepared from alcohol tinctures of walnuts, adding wormwood and cloves. Additionally, this drug includes grapefruit seed extract. The drug is prepared in the following ratio wt.h. components per 100 parts by weight walnut tinctures:

Ground wormwood 60-150 Ground cloves 50-200 Grapefruit Seed Extract 50-150

Known drug Triplet No. 1, developed by a doctor of medical sciences, professor V. Ivanchenko (“Bulletin of healthy lifestyle” No. 8 (140), 1999). Troika No. 1 includes: tansy (flower basket), bitter wormwood grass, and clove powder.

Tansy 3 g Wormwood grass 1 g Clove powder 1.5 g

This drug is the closest to the proposed invention and can be selected as an analogue. The disadvantage of the Troika No. 1 drug is that in order to achieve a therapeutic effect, it is necessary to use rather large doses of the drug and strictly in accordance with a certain dosage regimen, and this causes difficulties for patients in treatment.

Another variant of a plant-based anthelmintic agent, available in tablet or capsule form, is known - “Triplet Evalar” (RF patent No. 2241482), which contains wormwood, tansy, cloves and excipients in the following ratio of components, wt.%:

Wormwood extract 0.7-2.0 Wormwood powder 1.7-10.0 Tansy extract 2.8-8.0 Tansy powder 5.7-14.3 Clove powder 28.6-72.0

Reducing the volume of the dose while maintaining the activity of the components is achieved by a combination of the use of plant materials in a tablet in the form of a dry extract and powder. However, for effective treatment, it is necessary to use a large number of capsules (6 pcs.) Daily, which can lead to intoxication of the body with the components of the drug. Also, this preparation does not take into account the need to neutralize the toxins released by helminths upon death.

The present invention is directed to reducing the daily dose of each of the active substances, due to their combined combined effects; expanding the range of therapeutic and prophylactic effects on the body and increasing the patient's convenience during the course of treatment.

The claimed technical result is achieved by the fact that the anthelmintic agent made in accordance with the present invention contains wormwood extract, powder of tansy flowers, clove bud powder, milk thistle extract, ginger root powder and garlic powder in the following ratio, wt.%:

Milk Thistle Extract, with a silymarin content of at least 70% 6.5-7.8% Wormwood extract 14.7-18.0% Tansy flower powder 7.3-8.2% Clove bud powder 37.0-45.0% Ginger Root Powder 9.6-11.7% Garlic powder 14.7-18.0% Excipients rest

This drug is a complex of components that are well established in folk medicine and have antihelminthic, antimicrobial and hepatoprotective properties in dosages that provide maximum efficiency, safety and ease of use for the consumer. In addition, the composition and concentration of the components of the claimed drug allows you to act not only on adult parasites, but also on their larvae.

An anthelmintic agent differs from its predecessors in that in addition to wormwood, tansy and cloves, it includes ginger, garlic (as an anthelmintic and antibacterial component) and spotted milk thistle (as a hepatoprotector). The drug can be used in tablet form or in capsule form.

The leaves and grass of bitter / ordinary wormwood (Artemisia absinthium / vulgaris L.) contain essential oils, which contain large amounts of α- and β-thujone, azulene, gamazulene, organic acids, glycosides, and flavonoids. Typically, a wormwood extract is used in the preparation. Bitter wormwood normalizes the functioning of the gastrointestinal tract, improves digestion, enhances the separation of bile and improves its outflow, stimulates the secretion of gastric juice, has an antiparasitic effect, is especially effective against roundworms (roundworms, pinworms).

Common tansy (Tanacetum vulgare L.) contains an essential oil, which contains sesquiterpene lactones, α- and β-thujone, ketones, camphor, borniol, linen; flavonoids: quercetin, luteolin, rutin, apigenin, etc. organic acids, bitterness, tannins, sugars, vitamin C, carotenoids, macro- and microelements. Tansy ordinary enhances the secretion of the glands of the gastrointestinal tract and tones its muscles, has analgesic, anti-inflammatory and anthelmintic effects. The component has an abortive effect - it is forbidden to use preparations containing tansy during pregnancy.

Clove buds (Syzygium aromaticum L.) contain a large amount of essential oil, the main component of which is eugenol, which has a strong antiseptic effect. Cloves stimulate appetite, reduce the processes of fermentation and decay in the intestines, destroy eggs of worms.

Ginger (Zingiber officinale) contains biologically active substances such as gingerol and showhalol, the anthelmintic effect of which is aimed primarily at parasite larvae. Ginger also includes camphene, cimeol, bisabolene, borneol, citral, linaool, vitamins A, C, B1, B2. Ginger is used as a tonic, restorative, antimicrobial and fungicidal agent, stimulates appetite, improves digestion.

Garlic (Allium sativum L.) contains volatile, the main of which are allicin, geraniol, rutin, quercetin. Garlic has a general strengthening effect, stimulates the immune system, has anthelmintic, antimicrobial, antiviral and fungicidal activity, enhances the motor and secretory activity of the gastrointestinal tract, and inhibits the processes of fermentation and decay in the intestines.

Milk Thistle (Silybum marianum L.) contains flavonoids and flavolignans (a group of substances combined under the general name silymarin), which have recognized hepatoprotective properties. Milk thistle also contains alkaloids, saponins, tyramine, histamine, some vitamins. The components of milk thistle also contribute to an increase in the formation and outflow of bile, improve the secretory and motor function of the gastrointestinal tract.

Thus, all components of the composition have an antiparasitic effect. Tansy and wormwood kill adult parasites (mainly roundworms - pinworms and roundworms), cloves, ginger and garlic destroy their larvae, have antimicrobial activity and activity, and milk thistle (silymarin content of at least 80%), which has a hepatoprotective effect, since dying helminths emit toxins that need to be neutralized. In addition, along with the antiparasitic action, the components contribute to the normalization of the secretory and motor functions of the digestive system.

The combination in the composition of powders and dry plant extracts in the declared amounts with the addition of the necessary amount of physiologically acceptable excipients allows preserving the biologically active substances of plants as fully as possible and creating an oral form conveniently enclosed in hard gelatin capsules made of an inert material. Also, the composition may be presented in the form of coated tablets. These types of formulations can isolate the bitterness of the components contained in the preparation from taste buds, preventing their irritation. Dosages of the components are calculated on the basis of research and the most effective alternative recipes.

The daily rate of active ingredients commonly used for an anthelmintic is shown in the table.

Component Name Daily rate (for 4 capsules or tablets), mg Amount in 1 capsule, mg Milk Thistle Extract (Silybum marianum), with silymarin content of at least 70% 88 ± 9 22 ± 3 Fragrant Carnation Buds (Syzygium aromaticum) 500 ± 50 125 ± 13 Pharmaceutical Ginger Root (Zingiber officinale) 130 ± 13 33 ± 4 Common tansy (Tanacetum vulgare) 100 ± 10 25 ± 3 Wormwood or ordinary wormwood (Artemisia absinthium / vulgaris) 200 ± 20 50 ± 5 Sowing garlic (Allium sativum) 200 ± 20 50 ± 5 Excipients According to TU According to TU

To give a mixture of these powders flowability and formability, a certain amount of physiologically acceptable excipients has been added to the composition. As a rule, the amount of excipients does not exceed 2 wt.%.

The proposed tool is easy to use. The composition includes only natural plant components, the combined effect of which exceeds their effect when taken separately and has not only anthelmintic, but also hepatoprotective effect.

Implementation Example:

The preparation made in accordance with the present invention contains: spotted milk thistle extract, allspice clove bud, pharmaceutical ginger root, tansy vulgaris, common wormwood (or bitter), inoculated garlic in the amounts indicated in the table. It is a loose powder from a mixture of dry extracts and parts of plants with a characteristic spicy smell. Individual doses are packaged in hard gelatin capsules weighing 305 mg, which are packaged in blisters of 10 pcs. in each. Capsules are made of an inert material that allows you to isolate the bitterness of the components contained in the preparation from taste buds. Dosages of the components are calculated on the basis of research and the most effective alternative recipes. As auxiliary components, Aerosil 380, magnesium stearate and K17 are used. The amount of the mentioned excipients corresponds to the safety level admissible by the State Pharmacopia for preparations enclosed in hard gelatin capsules.

The drug is intended for children over 14 years of age and adults in contact with animals and traveling to places of probable parasite infection. The duration of the course is 10-14 days, 2 capsules 2 times a day. The use of a laxative is recommended, the effect of which should occur 5-6 hours after taking the drug.

Claims (5)

1. An anthelmintic agent containing wormwood extract, tansy flower powder and clove bud powder, characterized in that it contains common or bitter wormwood extract and additionally contains spotted milk thistle extract, ginger root powder and garlic powder in the following ratio, wt.%:
Milk Thistle Extract with a silymarin content of at least 70% 6.5-7.8 Common wormwood extract or bitter 14.7-18.0 Tansy flower powder 7.3-8.2 Clove bud powder 37.0-45.0 Ginger Root Powder 9.6-11.7 Garlic powder 14.7-18.0 Excipients Rest 2. The anthelmintic agent according to claim 1, characterized in that it contains bitter wormwood extract. 3. The anthelmintic agent according to claim 1, characterized in that it has an encapsulated form. 4. The anthelmintic agent according to claim 3, characterized in that as auxiliary substances it contains: Aerosil 380, magnesium stearate, K17 plasdon. 5. The anthelmintic agent according to claim 1, characterized in that it has a tabletted shell form.