RU2432926C1 - Method of treating diseases of musculoskeletal system in animals and medication for its realisation - Google Patents

Abstract

FIELD: medicine. ^ SUBSTANCE: method of treating diseases of musculoskeletal system in animals includes application of medication on the region of joint. On the region of joint daily 1-3 times with light rubbing in movements until complete absorption applied is medication, which contains complex phytoextract - 0.5-7.0, glucosamine hydrochloride - 0.2-3.0, chondroitin sulfate - 0.2-3.0, medicinal bitumen - 0.2-2.0, sea-buckthorn oil - 0.2-5.0, glycerol -0.5-6.0, olive oil - 0.5-10.0, polyethylene glycol stearate 400 - 0.5-10.0, carbopol - 0.1-1.0, sodium hydroxide 0.1-2.0, kathon - 0.05-0.1, water - to 100. Treatment course constitutes not less than 10 days. ^ EFFECT: method and medication produce anti-inflammatory, pain-killing and healing action in treatment of diseases of musculoskeletal system in animals. ^ 4 cl, 6 ex

Description

The group of inventions relates to the field of veterinary medicine, in particular to the treatment of diseases of the musculoskeletal system in animals.

A known method of treating diseases of the musculoskeletal system using the transdermal balm "Miralgin", which includes grape seed oil, eikanol, essential oil of clary sage, eucalyptus, cloves, cypress, mint, tea tree, phytoextract arnica, licorice, carotene. Products of the Mirra company, reference book, M., 1998, v.1, p.41).

However, the known method and means are used to treat people, and their disadvantage is the short duration of the analgesic effect.

A known method of treating diseases of the musculoskeletal system with the help of a complex preparation, including a hydrophobic composition and a hydrophilic composition. Both compositions contain active substances of plant origin (RU 2308962 C1, 10.27.2007).

However, the known method and tool is also not suitable for use on animals.

The closest is a method of treating diseases of the musculoskeletal system with a tool containing chitosan and essential oils of eucalyptus, fir, lavender, juniper, lemon and geranium (RU 2180581 C1, 03.20.2002).

However, this invention also relates to medicine. The proposed composition is recommended for use as an auxiliary external agent in humane medicine in the treatment of diseases of the musculoskeletal system, and it cannot be used in the treatment of animals.

The objective of this group of inventions is to create a non-laborious method for the treatment of diseases of the musculoskeletal system in animals with the help of a tool containing highly effective components.

The problem in terms of the method is solved by the fact that in the method of treating diseases of the musculoskeletal system in animals, comprising applying to the joint area a medicine, according to the invention, as a medicine, apply the agent lightly rubbing the substance on the joint area 1-3 times daily until completely absorbed containing complex phytoextract of celandine, wormwood, St. John's wort, calendula flowers, pine buds, chamomile flowers, rose hips, caraway seeds, fennel, thyme, yarrow, licorice root , Peppermint leaves, glucosamine hydrochloride, sulfate hondroetina, mummy, sea buckthorn oil, glycerol, olive oil, polyethylene glycol 400 stearate, carbopol, sodium hydroxide, Cato and water in the following component ratio, wt.%:

complex phytoextract 0.5-7.0 glucosamine hydrochloride 0.2-3.0 chondroetin sulfate 0.2-3.0 mummy 0.2-2.0 sea buckthorn oil 0.2-5.0 glycerol 0.5-6.0 olive oil 0.5-10.0 polyethylene glycol stearate 400 0.5-10.0 carbopol 0.1-1.0 sodium hydroxide 0.1-2.0 caton 0.05-0.1 water up to 100,

however, the course of treatment is at least 10 days.

The problem is also solved by the fact that an additional compress is applied to the joint area for at least 8 hours.

Moreover, if the course of treatment is more than a month, then after 30 days they take a break of at least two weeks.

The problem in terms of a medicinal product for the treatment of diseases of the musculoskeletal system in animals is solved by the fact that the medicinal product according to the invention contains a complex phytoextract of celandine, wormwood, St. John's wort, calendula flowers, pine buds, chamomile flowers, rosehips, caraway seeds, fennel, thyme, yarrow, licorice root, peppermint leaves, glucosamine hydrochloride, chondroetin sulfate, mummy, sea buckthorn oil, glycerin, olive oil, polyethylene glycol stearate 400, carbopol, sodium hydro seed, cato and water in the following components, wt.%:

complex phytoextract 0.5-7.0 glucosamine hydrochloride 0.2-3.0 chondroetin sulfate 0.2-3.0 mummy 0.2-2.0 sea buckthorn oil 0.2-5.0 glycerol 0.5-6.0 olive oil 0.5-10.0 polyethylene glycol stearate 400 0.5-10.0 carbopol 0.1-1.0 sodium hydroxide 0.1-2.0 caton 0.05-0.1 water up to 100

Included in the complex phytoextract (LLC Medlinfarm, Russia):

- celandine - has bactericidal, anti-inflammatory properties;

- wormwood - has anti-inflammatory and antiseptic effects;

- St. John's wort - has anti-inflammatory, astringent, antiseptic effect, stimulates tissue regeneration. It has high antibacterial activity against Staphylococcus aureus and other bacteria. Used for trophic ulcers, burns;

- Calendula flowers - have anti-inflammatory, antiseptic, antispasmodic effect, improve tissue regeneration processes. Used externally for wounds, burns, abrasions, trophic ulcers;

- pine buds - have a disinfectant and anti-inflammatory effect. They have an irritating and antiseptic effect and are used for radiculitis, myositis, joint diseases;

- chamomile flowers - have a sedative, anti-inflammatory, antiseptic, analgesic, antispasmodic, anti-allergic effect, accelerate the regeneration processes, are used for pain in the joints;

- rose hips - have a general strengthening and anti-inflammatory effect, improve metabolism, favorably affect vascular permeability, stimulate the regeneration of the skin and mucous membranes. Used for dermatitis, bedsores, cracks and abrasions;

- cumin - has an antispasmodic and antiseptic effect;

- fennel - has anti-inflammatory, antispasmodic and antibacterial effects;

- thyme - has a bactericidal and analgesic effect. It is used for hives, long-term non-healing wounds, trophic ulcers;

- yarrow - has a hemostatic, antispasmodic, anti-inflammatory, bactericidal, astringent, anti-allergic effect. It is used for long non-healing wounds, trophic ulcers;

- licorice root - has an ulcer healing, antispasmodic, wound healing, capillary-strengthening, anti-inflammatory effect;

- peppermint leaves - have antispasmodic, anti-inflammatory and antiseptic effects, have general strengthening and wound healing properties.

Glucosamine hydrochloride - has anti-inflammatory and analgesic effects. Stimulates the biosynthesis of aminoglycans, helps restore the cartilage surfaces of the joints. It normalizes the production of intraarticular fluid, which leads to a decrease in degenerative changes and pain in the joints, improves their mobility.

Chondroetin sulfate - is involved in the construction of the main substance of cartilage and bone tissue. It improves phosphorus-calcium metabolism in cartilage, inhibits enzymes that disrupt the structure and function of articular cartilage, and inhibits the degeneration of cartilage. It stimulates the synthesis of glucosaminoglycans, normalizes the metabolism of hyaline tissue, and promotes the regeneration of cartilage surfaces and articular bags. Prevents compression of connective tissue, increases the production of intraarticular fluid, increases the mobility of the affected joints. Slows down bone resorption, reduces calcium loss and accelerates bone tissue repair, inhibits the progression of osteoarthritis. It has an analgesic effect, reduces joint pain, pain at rest and when walking, the severity of inflammation.

Mumiye - has anti-inflammatory and bactericidal agents, improves metabolism, stimulates regenerative processes, and promotes better blood supply to damaged tissues.

Sea buckthorn oil contains a mixture of carotene and carotenoids, tocopherols, chlorophyll substances and glycerides, oleic, linoleic, palmitic, stearic acids. It has anti-inflammatory and wound healing effects.

Glycerin acts softly on the fabric and at the same time astringent. The local action of glycerin is due to its ability to absorb water and envelop tissues. Outwardly, glycerin is prescribed as an emollient, slightly irritating to the skin and improves the metabolism in it.

I use olive oil as a solvent for medicinal substances that are part of the composition for penetration through the skin.

The technical result of the claimed group of inventions in terms of the method is to reduce its complexity, and in the part of the drug is to obtain a highly effective drug with anti-inflammatory, analgesic and healing effect in the treatment of diseases of the musculoskeletal system in animals.

The invention is illustrated by the following examples, which, however, do not limit the scope of the claims of the applicant.

Example 1

The drug is manufactured according to the technological scheme in stages:

- Preparation of equipment, premises, equipment, workwear.

- Unloading of raw materials.

- Weighing raw materials.

- Loading of raw materials into the homogenizer.

- Cooking cream.

- Filling or filling of bottles, tubes, cans.

- Corking of bottles, cans of finished products.

- Quarantine storage until a positive conclusion is received from the technical control department.

- Labeling and / or packaging in individual packaging.

- Formation of group packaging and labeling.

- Storage at the warehouse of finished products.

Example 2

Preparation of a medicinal product in the form of a cream.

Through the loading hatch, the calculated amount of water is poured into the reactor, a weighed portion of carbopol is poured, and stirred until complete dissolution. After mixing, add the calculated amount of glycerol, glucosamine hydrochloride, mummy. Sea buckthorn oil, olive oil, polyethylene glycol stearate 400, complex phytoextract are mixed, mixed and added to the reactor. A solution of sodium hydroxide, a caton are added, mixed, homogenized. Get the tool of the following composition, wt.%:

complex phytoextract 0.5-7.0 glucosamine hydrochloride 0.2-3.0 chondroetin sulfate 0.2-3.0 mummy 0.2-2.0 sea buckthorn oil 0.2-5.0 glycerol 0.5-6.0 olive oil 0.5-10.0 polyethylene glycol stearate 400 0.5-10.0 carbopol 0.1-1.0 sodium hydroxide 0.1-2.0 caton 0.05-0.1 water up to 100

After mixing and dissolving the components, the drug is homogenized and packaged.

We give specific examples of therapeutic efficacy of the drug.

Example 3

The experiments were conducted at the Moscow Central Hippodrome in August-October 2009.

The experimental group included horses with diseases of the extremities - 9 trotter and sport horses aged 2 to 12 years. Four horses were diagnosed with chronic synovitis of the hock joints with clinical signs: joint swelling, fluctuation, and relatively quick fatigue of the animals. Four animals were diagnosed with chronic finger flexor tendovaginitis with clinical signs: diffuse swelling of the tendons, swelling, tenderness upon deep palpation, when viewed from the side, the tendon was protruding outward. In one horse with clinical signs: painful swelling of the joint, firm consistency, mild lameness, chronic fibrous synovitis of the put joint was diagnosed.

The drug was rubbed in the region of the synovitis of the hock joints daily after training the animals. The course of treatment was one month. After treatment, a decrease in eversion of the joints was noted, animals moved better and more willingly. In two horses, fluid in the joints almost disappeared and eversion in the joints was not visible. A compress was additionally applied to the region of the put joints and the thickened tendons of the finger flexors. To do this, first rubbed the drug until completely absorbed, then wrapped the problem area with a layer of gauze, compress paper, a padded jacket and bandaged with an ordinary bandage. When applying compresses for a long time, the skin warms up, its pores expand and the components of the drug act faster. The components of the drug have anti-inflammatory and analgesic effects, stimulate the synthesis of aminoglycans, help restore the cartilage surface of the joints, normalize the production of joint fluid, which leads to a decrease in degenerative changes and pain in the joints, improves their mobility. The procedures were carried out after training horses, compresses were left for 8 hours. For the duration of the training, the tendon and fetter areas of all these horses were bandaged and put on their nails. The course of treatment ranged from 30 to 45 days. After 30 days of treatment, a break of 2 weeks was made. As a result of treatment, the tendon area became softer, the soreness decreased, the animals moved more willingly. Despite the fact that the drug was used for a long time, skin irritation in horses was not observed. The product is quickly absorbed, does not leave spots on bandages and greasy shine on the coat of horses.

Thus, in horses with chronic diseases of the joints and tendons in need of constant supportive treatment, the drug has an effective therapeutic effect.

Example 4

The experiment was carried out at the Moscow stud farm on 8 horses with a diagnosis of hock synovitis. The drug was rubbed daily 1-3 times a day in the joints for 30 days. The fluid effusion stopped, then the swelling gradually resolved.

Example 5

In case of an acute horse, brown the calcaneus daily, the medicine is rubbed daily once a day for 10 days. The product is well and quickly absorbed into the skin of the horse, does not leave a greasy sheen on the skin of the animal and the hands of a veterinarian. Bursitis 5 cm in diameter decreased to 2-2.5 cm.

Example 6

In a foal at the age of 6 months, hocks of the hock joint enlarged to 11 cm were observed hot upon palpation and slight lameness. Diagnosed with hock synovitis. After daily (once a day) rubbing the claimed drug into the affected joint, the eversion of the joint decreased by 70%.

As a result of the studies, it was found that the claimed drug has an indirect anti-inflammatory and analgesic effect in cases of joint injuries, osteoarthritis, osteochondrosis, shoulder-shoulder polyarthritis, normalizes calcium deposits in bone tissue, inhibits the progression of degenerative processes in the joints, and contributes to the disappearance of edema and pain syndrome joints, improves skin elasticity and hair shine in the joints.

In addition, since The claimed drug has a high penetrating ability, is easily absorbed and does not leave greasy marks, The claimed method of treating diseases of the musculoskeletal system in animals is not difficult.

Claims (4)

1. A method of treating diseases of the musculoskeletal system in animals, comprising applying a drug to a joint region, characterized in that, as a medicine, 1-3 times a light rubbing motion is applied to the joint region daily until completely absorbed, containing a complex celandine phytoextract, wormwood, St. John's wort, calendula flowers, pine buds, chamomile flowers, rosehips, caraway seeds, fennel, thyme, yarrow, licorice root, peppermint leaves, glucosamine hydrochloride, hond oetina sulfate, mummy, sea buckthorn oil, glycerol, olive oil, polyethylene glycol 400 stearate, carbopol, sodium hydroxide, Cato and water in the following component ratio, wt.%:
complex phytoextract 0.5-7.0 glucosamine hydrochloride 0.2-3.0 chondroetin sulfate 0.2-3.0 mummy 0.2-2.0 sea buckthorn oil 0.2-5.0 glycerol 0.5-6.0 olive oil 0.5-10.0 polyethylene glycol stearate 400 0.5-10.0 carbopol 0.1-1.0 sodium hydroxide 0.1-2.0 caton 0.05-0.1 water up to 100,
however, the course of treatment is at least 10 days. 2. The method according to claim 1, characterized in that an additional compress is applied to the joint area for at least 8 hours 3. The method according to claim 1, characterized in that if the course of treatment is more than a month, then after 30 days they take a break of at least two weeks. 4. The drug for the treatment of diseases of the musculoskeletal system in animals according to the method according to claim 1, characterized in that it contains a complex phyto-extract of celandine, wormwood, St. John's wort, calendula flowers, pine buds, chamomile flowers, rose hips, caraway seeds, fennel, thyme , yarrow, licorice root, peppermint leaves, glucosamine hydrochloride, chondroetin sulfate, mummy, sea buckthorn oil, glycerin, olive oil, polyethylene glycol stearate 400, carbopol, sodium hydroxide, catone and water with the following content of compo nents, wt.%:
complex phytoextract 0.5-7.0 glucosamine hydrochloride 0.2-3.0 chondroetin sulfate 0.2-3.0 mummy 0.2-2.0 sea buckthorn oil 0.2-5.0 glycerol 0.5-6.0 olive oil 0.5-10.0 polyethylene glycol stearate 400 0.5-10.0 carbopol 0.1-1.0 sodium hydroxide 0.1-2.0 caton 0.05-0.1 water up to 100