RU2422142C2 - Antihelminth medication for treatment of boars - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of veterinary helminthology. Antihelminth medication for boar treatment, includes fenbendazole, flavour additive and rye flour with component ratio fenbendazole: flavour addition: rye flour 1.0:0.006:98.9. Antihelminth medicine is highly effective, more economical, less toxic, is well eaten by boars.

EFFECT: medicine will make it possible to reduce boar morbidity by helminthiasis sharply.

2 tbl, 2 ex

Description

The invention relates to the field of veterinary helminthology, in particular to the development of an effective treatment for wild boars for helminthiases.

Helminth infections of wild boars are widespread and often lead to the death of animals. As a rule, up to 20% of young boars die from helminths. Damage also manifests itself in the form of a decrease in weight gain, fatness, fertility, and culling of affected products. And trichinosis is a helminthozoonosis, and therefore boars can serve as a source of human infection. In this regard, the treatment of helminthiases of wild boars is very important.

Currently, for the treatment of helminthiases of wild boars, nilverm is used, which has activity against roundworms and esophagostas (2).

The disadvantages of this drug are the low chemotherapeutic index, toxicity and side effects (1).

Closest to the claimed technical solution is panacur, which is used in cattle, sheep against nematodoses, including ostertagia, hematosis, dictiocaulosis, esophagostomiasis, nematodirosis, strongyloidosis, pigs against ascariasis, esophagostomy, strongilophilosis and triho. The drug is safe for animals, does not have side effects. It contains 22.2% of fenbendazole. It is administered orally with food in a dose of DV: 7.5 mg / kg to cattle, 5.0 mg / kg to sheep and 20 mg / kg to pigs (3). The disadvantage of this drug is its poor eatability by wild boars due to their high sensitivity to the smell of drugs.

The objective of these studies was to develop an effective drug for the treatment of helminthiases of wild boars, which could voluntarily be eaten by wild boars, and was also convenient to use, economical, and less toxic.

The proposed remedy for the treatment of wild boar helminthiases includes the use of a feed-drug mixture consisting of the active ingredient anthelmintic fenbendazole (-5-phenylthio-2-benzimidazole carbamate), meat flavoring 645 060N (hereinafter flavoring agent) and rye flour in the following ratio of components - 1 : 0.006: 98.9.

The Vigisol feed preparation is a white and beige colored powder. The introduction of fenbendazole in its composition provides high anthelmintic efficiency and good tolerance by animals, the addition of a flavoring agent and a decrease in the content of the active substance, fenbendazole to 1%, improves the eatability of the mixture, and the use of rye flour in this ratio reduces material costs and creates ease of use and dosing.

A comparative analysis of the proposed technical solution with the prototype shows that the claimed tool differs from the known one in that it is additionally added flavoring and the concentration of the active substance is reduced - fenbendazole.

For the preparation of Vigisol, 1 part of fenbendazole is taken, which is mixed with 98.9 parts of rye flour and 0.006 parts of flavoring is added.

Similarly to the described, an anthelmintic agent is obtained in which the components are in the ratios: fenbendazole: flavoring agent: rye flour - 5.0: 0.006: 94.9 and 10.0: 0.006: 89.9.

Example 1. The experiment was carried out on wild boars in different parts of the hunting farm of the Nizhny Novgorod region. Boars of the 1st plot were obtained with Vigisol food, in which the ratio of fenbendazole, flavoring and rye flour was 1.0: 0.006: 98.9.

The drug "Vigisol" was mixed with oats, scattered in a feeder at a dose rate of 20 mg / kg according to fenbendazole by voluntary eating. Animals of the 2nd plot received panacur (prototype) in the same dose of 20 mg / kg in terms of DV (fenbendazole). Wild boars of the 3rd section served as a control, but did not receive Vigisol.

The effectiveness of the proposed means of treatment "Vigisolom" was determined by the results of two studies of feces of wild boars of all areas before and 10-12 days after giving the drug.

The results of example 1 are shown in table 1 (appendix).

Example 2. The study of the eatability and effectiveness of “Vigisol” depending on the ratio of the active substance in it was carried out in a hunting farm on wild boars of different sites. Boars of the 1st plot were obtained with Vigisol food, in which the ratio of fenbendazole, flavoring and rye flour was 1.0: 0.006: 98.9.

Animals of the 2nd section - “Vigisol”, in which the ratio of fenbendazole, flavoring and rye flour is 5.0: 0.006: 94.9, and animals of the 3rd section - “Vigisol”, in which the ratio of fenbendazole, flavoring and rye flour - 10.0: 0.006: 89.9.

Boars of the 4th section received panacur (prototype) at a dose of 5 mg / kg in terms of DV (fenbendazole). Boars of the 5th section served as a control and did not receive Vigisol.

The effectiveness of "Vigisol" was determined by analogy with example 1. The results of example 2 are presented in table 2 (appendix).

When calculating the cost-effectiveness of treating wild boars for helminthiases, we proceeded from the fact that the price of 1 kg of panacura is 2320 rubles, and “Vigisol” is 50 rubles. The need of the proposed drug for the treatment of one animal per course of treatment is 100 g, and for the processing of one animal with panacur, 5 g is required. The cost of processing one animal with helminthiasis “Vigisol” (the proposed drug) is 5.0 rubles, and the prototype 11.6 rubles. The economic efficiency of Vigisol was 6.6 rubles per animal.

An analysis of the results shows that the use of the proposed remedy for the treatment of wild boars with helminthiases allows to obtain high efficacy in ascariasis, esophagostomiasis and metastrongylosis without manifesting side effects of the drug. The high efficiency of the proposed tool is due to good eatability by introducing a flavoring agent into the proposed drug and establishing the optimal concentration of the active substance.

In experiments on white rats, the toxicity of Vigisol was established in comparison with the prototype - panacur. The average lethal dose (LD ₅₀ ) of Vigisol is 15,000 mg / kg, and for panakur LD _{50 it} is 10,000 mg / kg.

The results show that the use of the proposed means of treating wild boars for helminthiases ensures their release from helminths. The decrease in the concentration of the active substance - fenbendazole and the addition of a flavoring agent to the preparation ensures the complete eating of the Vigisol mixture with food, increasing the efficiency and reducing material costs for treatment. Vigisol is less toxic than panacur.

Information sources

1. Arkhipov I.A. Side effects of anthelmintics and endectocides and ways to prevent them // Veterinary medicine. - 1999. - No. 12. - S.24-25.

2. Egorov A.N., Zolotov B.C. The results of deworming of wild boars of yearlings with nilverm in metastrongilosis // Transactions of the Zavidovsky Scientific Experimental Reserve. M., 1986 .-- Issue 5. - S. 173-177.

3. Instructions on measures for the prevention and elimination of animal diseases with helminth infections. M., 1999. - S. 37-41.

Table 1 Efficiency and eatability of the anthelmintic agent “Vigisol” for boar helminthiases Plot number A drug Number of animals The ratio of fenbendazole, flavoring and flour Dose, mg / kg Efficiency,% at: Eat-
capacity Side effect ascariasis esophagostomiasis metastrongility one Vigisol 28 1: 0.006: 98.9 20,0 one hundred one hundred one hundred Floor-
nost No 2 Panacur * (prototype) 26 - 20,0 17.3 16.8 15.6 Weak No 3 Control plot (untreated) 34 - - 0 0 0 - - * Active ingredient fenbendazole 22.2%

table 2 The effectiveness and eatability of the anthelmintic agent "Vigisol" depending on the ratio of the active substance in it - fenbendazole Plot number A drug Number of animals The ratio of fenbendazole, flavoring and flour Dose, mg / kg Efficiency,% at: Eatability ascariasis esophagostomiasis metastrongility one Vigisol thirty 1: 0.006: 98.9 20,0 one hundred one hundred one hundred Great 2 Vigisol 31 5: 0.006: 94.9 20,0 97.2 95.6 93,4 Good 3 Vigisol 23 10: 0.006: 88.9 20,0 56.3 47.2 45,2 Weak four Panacur * (prototype) 24 - 20,0 16.8 15.7 15,2 Weak 5 Control plot (untreated) 32 - 0 0 0 0 - * Active ingredient fenbendazole 22.2%

Claims (1)

An anthelmintic agent for treating wild boars, including fenbendazole, characterized in that it additionally contains a flavoring agent, rye flour with a ratio of the components of fenbendazole: flavoring agent: rye flour 1.0: 0.006: 98.9.