RU2483742C1 - Method of treating erectile or sexual disorders - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine, particularly to human sexology, and may be used to treat sexual and erectile disorders in males with suicidal behavior with underlying the family-sexual disharmony. For this purpose, the therapeutic regimen is added by the adaptogene Magic Staff ® in the third week of introducing antidepressants and tranquilisers.

EFFECT: invention provides the compensation for potential side effects of the antidepressants, as well as improves the patient's self-esteem.

4 cl, 1 ex

Description

The invention relates to medicine, namely to sexology, and can be used to treat erectile dysfunction (sex drive disorders) in men with suicidal behavior against the background of family-sexual disharmony.

Sexual disorders associated with intimate personality and family conflicts occupy a significant place in the causes of suicidal behavior.

Known methods of pharmacotherapeutic treatment of sexual dysfunctions of various origins (below are the most commonly used drugs in clinical practice).

1. Adaptogens and similar stimulants:

a) plant origin and beekeeping products: preparations of ginseng, Aralia of Manchurian, Leuzea, Rhodium rosea, Zamaniha, Eleutherococcus, Schisandra chinensis, pollen, apilak, tentex-forte, Verona.

b) animal origin: pantocrine, gypsy, casolin;

c) combined (animal and vegetable): Nanbao, testis composite, Magic Staff.

2. Vitamins and multivitamin complexes containing macro- and microelements and bioactive substances: tocopherol acetate, thiamine chloride, aevit, unicap-T, supradine.

3. Sex hormones and agents affecting hormonal support of the genital area:

a) androgens and their synthetic analogues: testosterone propionate, megiltestosterone, testosterone andecaonate (andriol), Mesterolone (Proviron), tetrasterone (Sustanon-250); testosterone undecaonate (nebido);

b) anabolic steroids: methandrostenolone, nandrolone decanoate (retabolil);

c) gonadotropins: chorionic gonadotropin (rotten, prophase);

g) prolactin inhibitors; bromocriptine (parlodel), cabergoline (dostinex);

e) antiandrogens: cyproterone acetate (androcur);

e) antiestrogens: tamoxifen citrate, clomiphencitrate (clostilbegit);

g) estrogens: ethinyl estradiol (microfollin), estriol (ovestin);

h) gestagens: dydrogesterone (duphaston), linestrenol (orgametrile, excluton);

i) combined gestogen - estrogen preparations: triziston, femoden and others;

j) combined estrogen - androgen drugs: gynodian depot.

4. Vasoactive drugs:

a) general action: pentoxifylline (trental), leaf extract of gingko biloba (tanakan), nicergoline (sermion), yohimbine, actovegin;

b) selective action: papaverine hydrochloride, alprostadil (caverject) for intracavernous administration; type 5 phosphodiesterase inhibitors for oral use: sildenafil (Viagra), tadalafil (Cialis), vardenafil (Levitra).

5. Drugs that stimulate the central and peripheral nervous system: strychnine nitrate, proserin, distigmine bromide (uretide).

6. Metabolites and enzymes that regulate metabolism: mildronate, adenosine triphosphoric acid (ATP), carnitine, riboxin, mexidol.

7. Psychotropic drugs:

a) tranquilizers: tofisopam (grandaxinum), alprazolam (xanax), mezapam (rudotel), mebicar, phenibut, phenazepam, buspirone (buspar);

b) antipsychotics: thioridazine hydrochloride (sonapax), sulpiride (betamax), alimemazine (teralen), periciazine (neuleptil);

c) antidepressants: sertradine (zoloft), fluvoxamim (fevarin); tianeptine (coaxyl), clomipramine (anafranide) hypericum (gelarium), pyrazidol;

d) psychostimulants: sydnocarb, sydnafen;

e) nootropics: pyriditol, picamalon.

8. Hepatoprotectors: Liv-52, Essential, Silibinin (legalon), Carsil.

9. Drugs acting in the field of peripheral nerve endings:

a) local anesthetics: aerosols and ointments based on lidocaine, trimecaine, etc .;

b) locally irritating ointments: himkolin, etc.

10. Preparations that improve the function of the prostate: trianol, prostatilen, speman, speman forte, prostanorm, etc.

11. Vaginal creams-lubricants: delight (grease-free lubricant - moisturizer with provitamin B5), etc.

Among adaptogens, the well-known drug Magic Staff® (Magic Staff®, Herby Life Science) helps to improve erectile function and enhance sexual desire in men. The drug has an adaptive and mild tonic effect.

The Magic Staff® includes Cordyceps sinensis (Chinese silkworm strands); deer antlers; Tibetan Dereza fruit extract; common bead seed extract; royal jelly (royal jelly). It is recommended to take in a single dose - 1-2 capsules 4-6 hours before the expected activity. Or in the form of a course dose - 2 capsules every 3 days for 1 month.

It is known that most antidepressants that are used in the treatment of affective pathology in patients with suicidal behavior against the backdrop of family-sexual disharmony have a side effect in the form of impaired sexual function (delayed ejaculation, decreased potency). Therefore, the introduction of adaptogens into the treatment regimen, which increase libido and improve erectile function, is relevant and reasonable.

The clinical effectiveness of Magic Staff® has been proven as a result of clinical trials: in Moscow in 2006, the Professional Association of Andrologists of Russia (PAAR) in conjunction with the Federal State Institution Design Bureau of the President of the Russian Federation. Under the leadership of the President of the PAAR, MD, professor of the Department of Endourology of the Russian Academy of Medical Sciences, Schepleva P.A .; in Novosibirsk in 2008, at the BIOVER MC under the supervision of a professor, MD Kulchavenya E.V .; in Kiev in 2006, by the Institute of Urology of the Academy of Medical Sciences of Ukraine under the leadership of the Chief Sexopathologist of the Ministry of Health of Ukraine, President of the Association of Sexologists and Andrologists of Ukraine (a member of the World Association of Sexual Medicine), Director General of the Ukrainian Institute of Sexology and Andrology, Head. Department of Sexology and Andrology, Institute of Urology, Academy of Medical Sciences of Ukraine, Professor I.I. Gorpinchenko; in 2004, in Belgium, by the European Association of Andrologists (AVER), a branch in Belgium, research director Professor E. Verhaeren.

An adaptogen was introduced into the treatment regimen of patients with suicidal behavior against the backdrop of family-sexual disharmony in order to correct the possible side effects of an antidepressant, namely, to improve sexual function in men, which was also reflected in the increase in patients' self-esteem. According to K. Imelinsky (1986), men are much more likely to experience sexual dysfunctions than women. He noted that sexual dysfunctions in men (erectile dysfunction), which make sexual intercourse impossible, cause suicidal attempts 10 times more often than sexual coldness in women, which also makes sexual intercourse difficult or impossible. The latter negatively affects the well-being of a man, largely dulls the “sensation” of the meaning of life, and also reduces self-esteem.

The treatment of sexual desire disorders - erection disorders in men with suicidal behavior against the backdrop of family-sexual disharmony - consists in administering the Magic Staff® adaptogen in the treatment regimen for the third week of taking antidepressants and tranquilizers. In this case, the drug is administered according to the scheme 1 capsule every 4 days (at 1, 5, 9, 13 from the beginning of taking the adaptogen). Further, the interval between doses of the next 4 capsules Magic Staff® is increased to 5 days. Thus, the drug is taken on days 18, 23, 28, 33, respectively, from the start of adaptogen therapy. The subsequent interval between doses of the next 4 capsules of Magic Staff® is increased by another 1 day. The drug is taken on 39, 45, 51, 57 days from the start of adaptogen therapy. Thus, the adaptogen treatment course is 12 capsules (3 packs of 4 capsules) or 57 days, which corresponds to a parallel, average in duration, antidepressant regimen.

In the most preferred embodiment of the invention, the Magic Staff® adaptogen is administered 1 capsule every 4 days for 13 days from the start of the administration of the Magic Staff® adaptogen, then the Magic Staff® adaptogen is administered 1 capsule every 5 days until the 33rd day from the start of the Magic adaptogen Staff®, the subsequent intake is carried out in 1 capsule every 6 days until the 57th day from the start of the administration of the Magic Staff® adaptogen.

This treatment avoids the side effects of antidepressants (in the form of a decrease in libido), reduces the risk of re-occurrence of affective pathology, and hence the possible re-occurrence of suicidal behavior, and normalizes sexual life in patients with suicidal behavior against the backdrop of family-sexual disharmony.

Example 1. Patient C, b. 1978 (31 years).

Diagnosis: insufficiency of a genital reaction, erection dysfunction of predominantly psychogenic origin, a mixed depressive and anxious reaction.

Complaints: complains of weak erections, decreased mood, irritability, temper, a feeling of insecurity with intimacy, thoughts of sexual inferiority, expresses suicidal thoughts.

In the patient, difficulties in the genital area arose against the background of alcohol intoxication. Incorrect behavior of the sexual partner, together with an erroneous assessment of their sexual manifestations, has led to the formation of persistent pathological attitudes in terms of sexual failure. Neurotic fixation on the genital area caused weakening of adequate erections and shortened coitus duration. Independent attempts to conduct treatment and change the situation did not bring positive results. In the future, almost all attempts to commit coitus ended in failure due to the lack of an erection or its sharp weakening. The formed alarming fears about possible sexual failures significantly increased the likelihood of these breakdowns even when trying to lengthen the period of preliminary caresses. The decrease in working capacity and frequent labor conflicts that appeared against the backdrop of affective pathology led to the appearance of thoughts about the unnecessary existence, fatigue from life, the desire to commit suicide.

In order to correct anxiety and depressive symptoms, he received an antidepressant for 3 months, a selective serotonin reuptake inhibitor (SSRI) and a tranquilizer for 28 days. To correct sexual dysfunctions, from the third week of the start of pharmacotherapy, the Magic Staff® adaptogen 400 mg was taken according to the scheme. The introduction of an adaptogen into the treatment regimen contributed to accelerating the reduction of symptoms of affective disorder, which in turn helped to conduct effective psychotherapeutic work aimed at creating a new vital perspective, strengthening the patient's antisuicidal barrier, and lowering the significance of the situation that led to suicidal behavior.

A week after the start of taking Magic Staff, the patient noted an increase in spontaneous and morning erections. I felt calmer and more confident. After 2 weeks, he made a successful attempt at coitus with a regular sexual partner. Suicidal thoughts disappeared.

Follow-up of 9 months: the steady duration of coitus persisted, sexual entrepreneurship 2 times a week. Relations with a regular sexual partner were characterized as harmonious, calm.

Thus, taking Magic Staff® in parallel with basic psychopharmacotherapy helps to prevent the risk of recurrence of suicidal behavior and normalize sexual life in patients with suicidal behavior against the backdrop of family-sexual disharmony.

Claims (4)

1. A method of treating sexual desire disorders - erectile dysfunction in men with suicidal behavior against the backdrop of family-sexual disharmony, which consists in introducing the Magic Staff® adaptogen disorder into the treatment regimen in the third week of taking antidepressants and tranquilizers. 2. The method according to claim 1, characterized in that the Magic Staff® adaptogen is administered in 1 capsule every 4 days for 13 days from the start of administration of the Magic Staff® adaptogen. 3. The method according to claim 1, characterized in that the adaptogen is administered in 1 capsule every 4 days for 13 days from the start of the administration of the Magic Staff® adaptogen and then the Magic Staff® adaptogen is administered in 1 capsule every 5 days until the 33rd day start taking the Magic Staff® adaptogen. 4. The method according to claim 1, characterized in that the Magic Staff® adaptogen is administered 1 capsule every 4 days for 13 days from the start of the administration of the Magic Staff® adaptogen, then the Magic Staff® adaptogen is administered 1 capsule every 5 days until 33- the day from the start of administration of the Magic Staff® adaptogen, the subsequent administration is carried out in 1 capsule every 6 days until the 57th day from the start of the Magic Staff® adaptogen.