RU2452507C1 - Phytotranquiliser - Google Patents

Abstract

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical industry for the purpose of preparing drugs. The drug contains powdered herbs (valerian, motherwort, melissa, Greek valerian) and/or their dry concentrates and Vitamin C.

EFFECT: drug extends the range of tranquilisers for compensation of individual intolerance to certain components of known preparations and provides body recovery from stress consequences, enhances immunity, protects against free radicals accompanying stress.

3 cl, 3 ex

Description

The invention relates to medicine, and more particularly to the pharmaceutical industry that produces drugs, and can be used as a sedative with a restorative effect from the destructive effect of free radicals formed during stress.

The well-known "Collection of medicinal plants for the treatment of neurosis and neurasthenia" (Patent RU 2174005, 7 IPC A61K 35/78. Authors Pechenevsky A.V. et al.), Which includes: herb lemon balm, peppermint, motherwort, thyme common, marjoram ordinary, St. John's wort, St. John's wort, yarrow, common wormwood, common sweet clover, flowers of hawthorn blood-red, calendula officinalis, medicinal chamomile, inflorescence of common hop, roots and rhizomes of medicinal valerian, Orni peony evasive, the smell of dill in the following proportions: 1.5: 1.5: 1.5: 1.5: 1: 1: 1: 1: 1: 1: 1,5: 1: 1: 1,5: 1: 1: 1.

Known drug "Novo-Passit" VIDAL HANDBOOK. Medicines in Russia. CJSC AstraFarmService. Moscow, 1998, page B-460 (or www.vidal.ru/poisk_preparatov/novo-passit.htm), consisting of dry extracts: rhizomes with valerian roots, lemon balm, St. John's wort, perforated leaves and flowers of common hawthorn, passiflora incarnate, common hop, black elderberry flowers).

Known biologically active food supplement "Night Dreams" / Pilate T.L. Federal Register of Dietary Supplements. - M .: Kogelet, 2000, p. 67 /, which includes chamomile flowers, blueberry leaves and fruits, chicory root, stevia leaves, green mint leaves, passion flower, hawthorn berries, valerian root, hop cones, scutellaria.

The closest analogue is the dietary supplement “Ivan Kuzmin 2” / Pilat T.L. Federal Register of Dietary Supplements. - M .: Kogelet, 2000, p. 65 /, which includes valerian, hops, lemon balm, peppermint, hawthorn, chamomile.

The disadvantages of the known drugs are:

1. The multicomponent nature of medicinal plants and, therefore, the individual intolerance of the individual components of the drug observed in individual patients.

2. Known drugs do not protect the body during stress from the damaging effects of free radicals that form in the human body during stress.

3. Medicinal plants are rare, not cultivated, and therefore preparations from them are expensive or are available in limited quantities.

The objective of the present invention is to expand the arsenal of sedatives on a plant basis.

The problem is solved by creating a phytotranquilizer, which is a mixture of rhizome powders with valerian roots, motherwort grass, lemon balm herbs, rhizomes with blue cyanosis roots and / or their dry extracts and vitamin C, with each component ranging from 0.1 to 2.5 parts . Phytotranquilizer can be made in the form of tablets or capsules.

The technical result is that the claimed tool exhibits a restorative effect of the destructive effect of free radicals formed during stress.

To solve the problem, plants growing in Russia were used.

Motherwort provides a quick sedative effect with nervous excitement (4 times faster than that of Valerian), insomnia, asthma, palpitations, neurosis, lowers blood pressure, slows the heart rate, relieves convulsive activity, has a beneficial effect on carbohydrate and fat metabolism, reduces the level of glucose, lactic and pyruvic acids, cholesterol, total lipids in the blood, normalizes protein metabolism.

Melissa has sedative properties, it is recommended for nervous weakness, migraine, and insomnia. In addition, lemon balm has a beneficial effect on the stomach, on the brain, especially with nerve spasms, dizziness and tinnitus.

Cyanosis blue has calming properties. According to the sedative activity of cyanosis in the experiment, it exceeds the drug Valerian by 8-10 times. Stimulates the function of the adrenal cortex, regulates lipid metabolism. Plant preparations significantly accelerate blood coagulation. Cyanotic saponins inhibit the development of atherosclerosis.

Valerian officinalis has a sedative, tranquilizing effect on the central nervous system, regulates cardiac activity, has antispasmodic and choleretic properties, and enhances the secretion of the glandular apparatus of the gastrointestinal tract. Valerian preparations have a positive neuroregulatory effect on the activity of the heart muscle and directly on the main mechanisms of heart automatism and the conduction system. In addition, galenical dosage forms of valerian possess coronary-expanding and hypotensive properties. Valerian is more effective with systematic and long-term use due to the slow development of a therapeutic effect.

During stress, the mechanism of enhanced aging of the body is triggered, free radicals are formed that damage the cell structure and contribute to their mutations. Therefore, prolonged stress contributes to the development of cancer. That is why it is important not only to calm down, but also to restore the body from the effects of stress. Therefore, the composition of the drug includes vitamin C - a powerful antioxidant, improves immunity, protects against aging and the effects of stress.

The proposed drug can be prepared by mixing powdered powders of plant materials (valerian, motherwort, lemon balm, cyanosis) with the addition of vitamin C or by mixing dry extracts of these plants with vitamin C and by mixing powders of individual plants with dry extracts of other plant components of the claimed composition with vitamin C.

Example 1

The composition of the drug in the form of a tablet weighing 65 mg includes:

Rhizome powder with valerian roots - 25 mg,

Rhizome powder with cyanosis blue roots - 10 mg,

Motherwort extract - 10 mg,

Lemon balm extract - 10 mg,

Vitamin C - 10 mg.

Example 2

The composition of the drug in the form of a mixture of powders of crushed plant material includes:

Rhizome powder with valerian roots - 250 mg,

Rhizome powder with cyanosis blue roots - 250 mg,

Motherwort herb powder - 250 mg,

Melissa herb powder - 250 mg,

Vitamin C - 250 mg.

Example 3

The composition of the drug in the form of a capsule weighing 300 mg includes:

Rhizome powder with valerian roots - 100 mg,

Rhizome powder with cyanosis blue roots - 50 mg,

Motherwort extract - 50 mg,

Lemon balm extract - 50 mg,

Vitamin C - 50 mg.

Clinical trials were conducted at the Regional Psychiatric Hospital. K.R.Evgrafova (Penza) for 50 patients with psycho-vegetative syndrome aged 18 to 60 years. For 14 days, 3 times a day with meals, 30 people from this group received two tablets of the claimed drug, and the remaining 20 patients received ordinary plant-based sedatives. In the main group receiving treatment, there was a positive dynamics of autonomic disorders. Manifestations from the cardiovascular system, headaches, vasomotor reactions decreased by 6 times, disorders of the gastrointestinal tract and the respiratory system decreased by 3 times. The subjects had a more stable pulse, there were no transient arrhythmias. Patients noted that blood pressure became more stable.

The phytotranquilizer does not cause side effects, including drowsiness in the daytime, does not adversely affect concentration and performance, and is not addictive.

In addition, the advantage of the phytotranquilizer is the possibility of its use both as a fast-acting symptomatic agent for stopping the symptoms of anxiety and excitement, and for long-term treatment (in complex therapy) of stress and anxiety disorders, as well as for their prevention.

Clinical trials in comparison with the control group showed that the claimed phytotranquilizer provides restoration of the body from the effects of stress, improves immunity, protects against the action of free radicals formed during stress.

Claims (3)

1. Phytotranquilizer, characterized in that it is a mixture of rhizome powders with valerian roots, motherwort grass, lemon balm herbs, rhizomes with cyanosis blue roots and / or their dry extracts and vitamin C, with each component ranging from 0.1 to 2, 5 pieces. 2. The phytotranquilizer according to claim 1 is made in the form of tablets. 3. The phytotranquilizer according to claim 1 is made in the form of capsules.