RU2312867C2 - СОЕДИНЕНИЕ, ВКЛЮЧАЮЩЕЕ 1-(2-МЕТИЛПРОПИЛ)-1Н-ИМИДАЗО[4,5-с][1,5]НАФТИРИДИН-4-АМИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБ СТИМУЛЯЦИИ БИОСИНТЕЗА ЦИТОКИНА В ОРГАНИЗМЕ ЖИВОТНЫХ - Google Patents
СОЕДИНЕНИЕ, ВКЛЮЧАЮЩЕЕ 1-(2-МЕТИЛПРОПИЛ)-1Н-ИМИДАЗО[4,5-с][1,5]НАФТИРИДИН-4-АМИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБ СТИМУЛЯЦИИ БИОСИНТЕЗА ЦИТОКИНА В ОРГАНИЗМЕ ЖИВОТНЫХ Download PDFInfo
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- RU2312867C2 RU2312867C2 RU2003126259/04A RU2003126259A RU2312867C2 RU 2312867 C2 RU2312867 C2 RU 2312867C2 RU 2003126259/04 A RU2003126259/04 A RU 2003126259/04A RU 2003126259 A RU2003126259 A RU 2003126259A RU 2312867 C2 RU2312867 C2 RU 2312867C2
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- imidazo
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- 150000001875 compounds Chemical class 0.000 title claims abstract 10
- 102000004127 Cytokines Human genes 0.000 title claims abstract 5
- 108090000695 Cytokines Proteins 0.000 title claims abstract 5
- 241001465754 Metazoa Species 0.000 title claims abstract 5
- 230000015572 biosynthetic process Effects 0.000 title claims abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 4
- 230000000638 stimulation Effects 0.000 title abstract 3
- UCPMSMNKGXUFCC-UHFFFAOYSA-N 1-(2-methylpropyl)imidazo[4,5-c][1,5]naphthyridin-4-amine Chemical compound C1=CC=NC2=C3N(CC(C)C)C=NC3=C(N)N=C21 UCPMSMNKGXUFCC-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 5
- 230000000694 effects Effects 0.000 claims abstract 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- KFAJXZVDBVRZRC-UHFFFAOYSA-N 1,5-naphthyridin-4-amine Chemical compound C1=CN=C2C(N)=CC=NC2=C1 KFAJXZVDBVRZRC-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
- 230000004071 biological effect Effects 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Abstract
Заявленные изобретения представляют собой соединение, включающее 1-(2-метилпропил)-1Н-имидазо[4,5-с][1,5]нафтиридин-4-амин, или фармацевтически приемлемую соль этого соединения, а также фармацевтическую композицию, применяемую для стимуляции биосинтеза цитокинов на основе вышеназванного соединения. Также заявлен способ стимуляции биосинтеза цитокинов в организме животных, заключающийся во введении в организм животного описанного выше соединения или соли. Технический результат - получено новое соединение, обладающее полезными биологическими свойствами. 3 н.п. ф-лы, 12 табл.
Description
Claims (3)
1. 1-(2-Метилпропил)-1Н-имидазо[4,5-с][1,5]нафтиридин-4-амин или фармацевтически приемлемая соль этого соединения.
2. Фармацевтическая композиция, характеризующаяся активностью при стимуляции биосинтеза цитокина и содержащая фармацевтически эффективное количество соединения или соли по п.1 настоящего изобретения и фармацевтически приемлемый носитель.
3. Способ стимуляции биосинтеза цитокина в организме животных, заключающийся во введении эффективного количества соединения или соли по п.1 настоящего изобретения в организм животного.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6927697P | 1997-12-11 | 1997-12-11 | |
| US60/069.276 | 1997-12-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000114496/04A Division RU2221798C2 (ru) | 1997-12-11 | 1998-12-11 | Имидазонафтиридины, фармацевтическая композиция на их основе, способ стимуляции биосинтеза цитокина и промежуточные вещества |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003126259A RU2003126259A (ru) | 2005-02-27 |
| RU2312867C2 true RU2312867C2 (ru) | 2007-12-20 |
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ID=22087889
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000114496/04A RU2221798C2 (ru) | 1997-12-11 | 1998-12-11 | Имидазонафтиридины, фармацевтическая композиция на их основе, способ стимуляции биосинтеза цитокина и промежуточные вещества |
| RU2003126259/04A RU2312867C2 (ru) | 1997-12-11 | 1998-12-11 | СОЕДИНЕНИЕ, ВКЛЮЧАЮЩЕЕ 1-(2-МЕТИЛПРОПИЛ)-1Н-ИМИДАЗО[4,5-с][1,5]НАФТИРИДИН-4-АМИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБ СТИМУЛЯЦИИ БИОСИНТЕЗА ЦИТОКИНА В ОРГАНИЗМЕ ЖИВОТНЫХ |
| RU2003126258/04A RU2314307C2 (ru) | 1997-12-11 | 1998-12-11 | СОЕДИНЕНИЕ, ВКЛЮЧАЮЩЕЕ 2-МЕТИЛ-1-(2-МЕТИЛПРОПИЛ)-1Н-ИМИДАЗО[4,5-c][1,5]НАФТИРИДИН-4-АМИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБ СТИМУЛЯЦИИ БИОСИНТЕЗА ЦИТОКИНА В ОРГАНИЗМЕ ЖИВОТНЫХ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000114496/04A RU2221798C2 (ru) | 1997-12-11 | 1998-12-11 | Имидазонафтиридины, фармацевтическая композиция на их основе, способ стимуляции биосинтеза цитокина и промежуточные вещества |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2003126258/04A RU2314307C2 (ru) | 1997-12-11 | 1998-12-11 | СОЕДИНЕНИЕ, ВКЛЮЧАЮЩЕЕ 2-МЕТИЛ-1-(2-МЕТИЛПРОПИЛ)-1Н-ИМИДАЗО[4,5-c][1,5]НАФТИРИДИН-4-АМИН, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕГО ОСНОВЕ И СПОСОБ СТИМУЛЯЦИИ БИОСИНТЕЗА ЦИТОКИНА В ОРГАНИЗМЕ ЖИВОТНЫХ |
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| JP (4) | JP4283438B2 (ru) |
| KR (3) | KR100563175B1 (ru) |
| CN (1) | CN1154647C (ru) |
| AT (3) | ATE333456T1 (ru) |
| AU (1) | AU753864B2 (ru) |
| BR (1) | BR9814275A (ru) |
| CA (1) | CA2311456C (ru) |
| CZ (1) | CZ307184B6 (ru) |
| DE (3) | DE69826518T2 (ru) |
| DK (1) | DK1512686T3 (ru) |
| EE (1) | EE04314B1 (ru) |
| ES (3) | ES2270249T3 (ru) |
| HR (1) | HRP20000363B1 (ru) |
| HU (1) | HUP0101155A3 (ru) |
| IL (4) | IL136556A0 (ru) |
| NO (3) | NO316687B1 (ru) |
| NZ (1) | NZ504776A (ru) |
| PL (1) | PL193915B1 (ru) |
| PT (3) | PT1512685E (ru) |
| RU (3) | RU2221798C2 (ru) |
| SI (1) | SI1512686T1 (ru) |
| SK (2) | SK286304B6 (ru) |
| TR (1) | TR200001705T2 (ru) |
| UA (1) | UA67760C2 (ru) |
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Families Citing this family (225)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5741908A (en) | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
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