RU2366175C1 - Disinfectant - Google Patents

Abstract

FIELD: chemistry.

SUBSTANCE: invention refers to the field of disinfection including the disinfectants used in prevention and treatment facilities, in ambulance and disinfection stations, child care centres, public catering facilities, public utilities, transport, agriculture firms, food and other branches of industry and in household use. The disinfectant includes polyhexamethylene guanidine hydrochloride and N,N-bis-(3-aminopropyl)dodecylamine as active substances (mass ratio 1:1-4), surfactant, odorant, water and functional additives (including oxyethylated monoethanolamides of the synthetic fatty acids, polyatomic fatty alcohols, carbamide, alkanolamine, EDTA salt) in determined ratios (wt %).

EFFECT: disinfectant takes the high antimicrobic action, is effective in low concentrations, posseses good detergency, stable at storage.

6 cl, 3 tbl, 12 ex

Description

The invention relates to means for disinfection in medical institutions, in ambulance stations, disinfection stations, in children's institutions at public catering facilities, public utilities, transport, agriculture, food processing enterprises and other industries national economy, the population at home, as well as for pre-sterilization cleaning (including combined with disinfection) of medical devices made of metals, rubber, glass, plastic (including endo ospreys and tools for them) in the health facility.

It is known that disinfectants based on salts of guanidine derivatives (PHMG) have a prolonged disinfecting effect on treated surfaces for viruses and spore cultures, for example, Biopag D preserves the disinfectant effect for up to 7 days (Handbook “Disinfectants”. Moscow, 2006. , p. 74). However, it is also known that they have a limited spectrum of antimicrobial activity, in particular they are weakly active against tuberculosis mycobacteria and fungi, and a high concentration of the active substance is required.

A disinfectant is also known including polyhexamethylene guanidine hydrochloride in combination with alkyldimethylbenzylammonium chloride, nonionic surfactant, perfume, color and water as the active ingredient. The indicated agent has a higher bactericidal effect compared to agents based on polyhexamethylene guanidine derivatives: it is active against a number of pathogenic microorganisms - Escherichia coli and Pseudomonas aeruginosa, staphylococci, enterococci, Candida genus fungi, but it is not active against viruses. To carry out fungicidal and anti-tuberculosis disinfection requires a long time (US Pat. RF №2057796, C11D 1/835, 3/48). All this limits the possibility of using the drug in medical institutions.

The closest in technical essence is a disinfectant that includes, as an active substance, a quaternary ammonium compound and / or a derivative of polyhexamethylene guanidine, and / or N, N-bis (3-aminopropyl) dodecylamine, a nonionic surfactant and salts of ethylenediaminetetraacetic (EDTU) or hydroxyethyl ethylidene ) acids, as well as dye, perfume and water (RF patent 2297248, from 04.20.2007, CL A61L 2/16). The disinfectant provides high antimicrobial properties against bacteria (except for mycobacteria), as well as viruses (including poliomyelitis), however, for tuberculosis and fungicidal disinfection, fairly high concentrations are required (0.56-0.8% of the active substance).

The objective of the invention is to increase antimicrobial activity, including against mycobacteria, viruses and fungi, providing a prolonged effect on microorganisms and viruses, using both for disinfection and pre-sterilization cleaning using the lowest possible effective concentration of the drug for processing medical devices.

The problem is solved by using a composite composition containing, as an active substance, a mixture of polyhexamethylene guanidine hydrochloride and N, N-bis (3-aminopropyl) dodecylamine, nonionic surfactant, perfume and water and functional additives, including ethoxylated monoethanolamides of synthetic fatty acids CLC fractions ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ , polyhydric synthetic fatty alcohols (SGS), urea, alkanolamine, ethylenediaminetetraacetic acid salt (EDTU).

The proposed composition contains the following components, wt.%:

Polyhexamethylene guanidine hydrochloride and N, N-bis- (3-aminopropyl) dodecylamine 0.2-20.0 Nonionic surfactant 0.1-20.0 Oxyethylated monoethanolamide SJK 0.1-10.0 Polyhydric alcohol 0.1-10.0 Urea 0.5-10.0 Alkanolamine 0.1-7.0 Salt EDTU 0.05-2.0 Perfume 0.1-1.0 Water rest

The problem is also solved by using polyhexamethylene guanidine hydrochloride N, N-bis- (3-aminopropyl) dodecylamine in a mass ratio of 1: 1-4.

The problem is also solved by the use of non-ionic surfactants of ethoxylated alkyl phenols and / or oxyalkylated fatty alcohols of fractions C ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ and / or amine oxides. As the ethoxylated alkyl phenols, the following can be used: neonol AF 9/6, neonol AF 9/10, neonol AF 9/12, or mixtures thereof. As oxyalkylated fatty alcohols of fractions C ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ , syntanol DS-10, syntanol BV, syntanol ALM-7 or syntanol ALM-10, syntanol 12/86, conol SMP, syntanol DT-308 can be used and others. Alkyl dimethyl amine oxide (Oksipav A) or cocamidopropylamine oxide (Oksipav AP) can be used as amine oxides.

The problem is solved in that synthetide-5 or syntamide-10 can be used as the ethoxylated monoethanolamides of synthetic fatty acids of fractions C ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ .

The problem is solved in that propylene glycol or glycerin can be used as a polyhydric alcohol.

The problem is also solved by the fact that as alkanolamine can be used monoethanolamine, diethanolamine or triethanolamine.

The following examples illustrate the invention.

Example 1

In a 4-necked flask with a stirrer, thermometer and reflux condenser, add the calculated amount of water, load urea - 5 g, propylene glycol - 1.2-5 g, EDTU salt - 2 g and stir until completely dissolved. Then, with constant stirring, syntanol ALM-10 - 10 g, syntamide-5 - 10 g, N, N-bis- (3-aminopropyl) dodecylamine (triamine) - 10.0 g and triethanolamine - 5 g are loaded. The contents of the flask are stirred, then load polyhexamethylene guanidine hydrochloride (Biopag D) - 10 g and stir until a homogeneous solution is obtained. (All calculations are given in terms of 100% substance.) After cooling the mass in the flask to room temperature, add 1 g of fragrance.

Example 2-12

The disinfectants of examples 2-12 are prepared in the same way as shown in example 1, but they change the composition and ratio of components. The compositions of the disinfectants of examples 1-12 are shown in table 1.

All disinfectants obtained in examples 1-12 have good detergent properties and a long shelf life (3 years).

Tables 2 and 3 show comparative data on the antimicrobial activity of the agent according to the invention in comparison with the known disinfectant (according to the prototype), obtained by the methods described in the “Methods of testing disinfectants to assess their safety and effectiveness”. M., 1998, part 2, close to the real conditions of use of funds.

Comparison of the results of biological tests shows that the disinfectant according to the invention allows to increase its bactericidal activity compared with the known agent, while the agent has good detergent properties, which allows for pre-sterilization cleaning of medical devices at a concentration of only 0.02-0.04% in based on the amount of active substances.

Table 1 The composition of the disinfectants according to the invention No. The composition of the funds The content of ingredients,% p / p one 2 3 four 5 6 7 8 9 10 eleven 12 one Polyhexamethylene guanidine hydrochloride 10.0 4.0 5,0 4.0 5,0 3.0 5,0 3.0 2.0 2.0 0.5 0.1 2 Triamine 10.0 8.0 15.0 16,0 5,0 6.0 10.0 12.0 6.0 8.0 1,0 0.1 3 Syntanol ALM-10 10.0 5,0 - 10.0 - - 5,0 - - - - 0.1 four Sintanol DT-308 - - 10.0 - - - - 20,0 - 8.0 5,0 - 5 Oksipav A - - - - 5,0 3.0 - - 2.0 - - - 6 Sintamide-5 5,0 7.0 7.0 10.0 5,0 3.0 - 5,0 3.0 2.0 1,0 0.1 7 Propylene glycol 5,0 3.0 - 7.0 10.0 - 7.0 8.0 - 4.0 3.0 0.1 8 Glycerol - - 8.0 - - 3.0 - - 10.0 - - - 9 Urea 5,0 5,0 10.0 8.0 5,0 3.0 5,0 5,0 3.0 5,0 7.0 0.5 10 Monoethanolamine 5,0 - - - - 4.0 - - - 3.0 3.0 0.1 eleven Diethanolamine - - - - 5,0 - 3.0 - - - - - 12 Triethanolamine - 5,0 5,0 3.0 - - - 3.0 7.0 - - - 13 Salt EDTU 2.0 0.5 1,0 0.5 0.5 0.8 0.5 1,0 0.4 0.5 0.3 0.05 fourteen Perfume 1,0 0.2 0.2 0.5 0.3 0.2 0.5 0.5 0.3 0.2 0.2 0.1 fifteen Water 47.0 62.3 38.8 41.0 59.2 74.0 64.0 42.5 67.3 67.3 79.0 98.75

table 2 Comparison of the bactericidal and virucidal activity of the disinfectant according to the invention and the means according to US Pat. RF 2 297 248 (prototype) Recommended concentration on DV,% Examples of the invention The tool according to the invention Disinfectant on the prototype, US Pat. RF 2297248 bacteria mycobacteria viruses bacteria mycobacteria viruses Example No. 1 0.03-0.24 0.36-0.48 0.2-0.3 0.04-0.32 0.56-0.8 0.24-0.32 Example No. 2 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 3 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 4 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 5 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 6 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 7 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 8 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 9 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 10 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 11 0.03-0.24 0.36-0.48 0.2-0.3 - - - Example No. 12 0.03-0.24 0.36-0.48 0.2-0.3 - - -

Table 3 Comparison of the bactericidal and virucidal activity of the disinfectant according to the invention and the means according to US Pat. RF 2 297 248 (prototype) No. p / p Processing Objects Recommended concentration on DV,% The tool according to the invention (according to example 2) Disinfectant on the prototype, US Pat. RF 2,297,248 bacteria mycobacteria viruses bacteria mycobacteria viruses one Indoor surfaces, hard furniture, surfaces of devices and apparatus 0.03 60 min 0.36 60 min 0.2 30 min 0.04 30 min 0.56-0.64 120-60 min 0.24 30 min 2 Sanitary equipment 0.03 60 min 0.36 60 min 0.2 30 min 0.04 30 min 0.64 60 min 0.24 30 min 3 Dishes with leftover food 0.12 90 min 0.48 60 min 0.24 30 min 0.24 60 min 0.8 120 min 0.24 30 min four Excreted laundry 0.24 60 min 0.36 60 min 0.3 30 min 0.32 60 min 0, 64 60 min 0.32 30 min

Claims (6)

A disinfectant, including polyhexamethylene guanidine hydrochloride and N, N-bis (3-aminopropyl) dodecylamine (triamine), nonionic surfactant, ethoxylated monoethanolamides of synthetic fatty acids, a salt of ethylenediaminetetraacetic acid (EDTA), which differs from it additionally contains polyhydric alcohol, urea and alkanolamine in the following ratio of components, wt.%:
Polyhexamethylene guanidine hydrochloride and N, N-bis (3-aminopropyl) dodecylamine (triamine) 0.2-20.0 Nonionic surfactant 0.1-20.0 Oxyethylated monoethanolamides FFA 0.1-10.0 Polyhydric alcohol 0.1-10.0 Urea 0.5-10.0 Alkanolamine 0.1-7.0 Salt EDTU 0.05-2.0 Perfume 0.1-1.0 Water Rest 2. The disinfectant according to claim 1, characterized in that it contains polyhexamethylene guanidine hydrochloride and N, N-bis (3-aminopropyl) dodecylamine in a weight ratio of 1: 1-4. 3. The disinfectant according to claim 1, characterized in that it contains, as a nonionic surfactant, ethoxylated alkyl phenols and / or oxyalkylated fatty alcohols of fractions C ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ and / or amine oxides (alkyldimethylamine oxide or cocamidopropylamine oxide ) 4. The disinfectant according to claim 1, characterized in that it contains ethoxylated monoethanolamides of synthetic fatty acids of fractions C ₁₂ -C ₁₄ or C ₁₀ -C ₁₆ . 5. The disinfectant according to claim 1, characterized in that it contains propylene glycol or glycerol as a polyhydric alcohol. 6. The disinfectant according to claim 1, characterized in that it contains monoethanolamine or diethanolamine or triethanolamine as alkanolamine.