RU2363361C2 - Задерживающий никотин агент и способ снижения содержания никотина - Google Patents

Задерживающий никотин агент и способ снижения содержания никотина Download PDF

Info

Publication number: RU2363361C2
Authority: RU; Russia
Prior art keywords: gum; nicotine; filter; aqueous liquid; inhibiting agent
Prior art date: 2004-02-19

Application number

RU2006133378/12A

Other languages

English (en)

Russian (ru)

Other versions

RU2006133378A (ru

Inventor

Наото ОДЗИМА (JP)

Наото ОДЗИМА

Тосио ОМОТО (JP)

Тосио ОМОТО

Ацуси КОЗАКАИ (JP)

Ацуси КОЗАКАИ

Хисакацу ИВАБУТИ (JP)

Хисакацу ИВАБУТИ

Original Assignee

Сан-Еи Ген Ф.Ф.И., Инк.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-19

Filing date

2005-02-18

Publication date

2009-08-10

2005-02-18 Application filed by Сан-Еи Ген Ф.Ф.И., Инк. filed Critical Сан-Еи Ген Ф.Ф.И., Инк.

2008-03-27 Publication of RU2006133378A publication Critical patent/RU2006133378A/ru

2009-08-10 Application granted granted Critical

2009-08-10 Publication of RU2363361C2 publication Critical patent/RU2363361C2/ru

Links

SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 171
229960002715 nicotine Drugs 0.000 title claims abstract description 171
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 171
238000000034 method Methods 0.000 title claims description 38
239000007788 liquid Substances 0.000 claims abstract description 130
239000000203 mixture Substances 0.000 claims abstract description 116
239000003795 chemical substances by application Substances 0.000 claims abstract description 104
235000019505 tobacco product Nutrition 0.000 claims abstract description 70
239000000779 smoke Substances 0.000 claims abstract description 57
229920001282 polysaccharide Polymers 0.000 claims abstract description 51
239000005017 polysaccharide Substances 0.000 claims abstract description 50
235000004298 Tamarindus indica Nutrition 0.000 claims abstract description 47
229920001285 xanthan gum Polymers 0.000 claims abstract description 37
229920002907 Guar gum Polymers 0.000 claims abstract description 28
235000010417 guar gum Nutrition 0.000 claims abstract description 28
239000000665 guar gum Substances 0.000 claims abstract description 28
229960002154 guar gum Drugs 0.000 claims abstract description 28
239000000679 carrageenan Substances 0.000 claims abstract description 24
229920001525 carrageenan Polymers 0.000 claims abstract description 24
229940113118 carrageenan Drugs 0.000 claims abstract description 24
239000004373 Pullulan Substances 0.000 claims abstract description 22
229920001218 Pullulan Polymers 0.000 claims abstract description 22
229920000609 methyl cellulose Polymers 0.000 claims abstract description 22
235000010981 methylcellulose Nutrition 0.000 claims abstract description 22
239000001923 methylcellulose Substances 0.000 claims abstract description 22
235000019423 pullulan Nutrition 0.000 claims abstract description 22
235000010418 carrageenan Nutrition 0.000 claims abstract description 19
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 19
240000004584 Tamarindus indica Species 0.000 claims abstract 6
150000004676 glycans Chemical class 0.000 claims abstract 6
230000000391 smoking effect Effects 0.000 claims description 95
229920000591 gum Polymers 0.000 claims description 86
230000002401 inhibitory effect Effects 0.000 claims description 86
235000010493 xanthan gum Nutrition 0.000 claims description 36
239000000230 xanthan gum Substances 0.000 claims description 36
229940082509 xanthan gum Drugs 0.000 claims description 36
229920000161 Locust bean gum Polymers 0.000 claims description 35
235000010420 locust bean gum Nutrition 0.000 claims description 35
239000000711 locust bean gum Substances 0.000 claims description 35
239000011347 resin Substances 0.000 claims description 32
229920005989 resin Polymers 0.000 claims description 32
239000001814 pectin Substances 0.000 claims description 31
229920001277 pectin Polymers 0.000 claims description 31
150000001720 carbohydrates Chemical class 0.000 claims description 29
235000010987 pectin Nutrition 0.000 claims description 29
239000011269 tar Substances 0.000 claims description 25
229920002472 Starch Polymers 0.000 claims description 23
239000008107 starch Substances 0.000 claims description 23
235000019698 starch Nutrition 0.000 claims description 23
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 21
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 20
229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 20
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 20
235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 20
239000001768 carboxy methyl cellulose Substances 0.000 claims description 20
239000008112 carboxymethyl-cellulose Substances 0.000 claims description 20
235000020357 syrup Nutrition 0.000 claims description 19
239000006188 syrup Substances 0.000 claims description 19
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 16
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 16
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 16
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 16
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 11
235000010356 sorbitol Nutrition 0.000 claims description 11
239000000600 sorbitol Substances 0.000 claims description 11
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 9
229920001353 Dextrin Polymers 0.000 claims description 9
239000004375 Dextrin Substances 0.000 claims description 9
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 9
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 9
235000019425 dextrin Nutrition 0.000 claims description 9
239000008103 glucose Substances 0.000 claims description 9
235000010449 maltitol Nutrition 0.000 claims description 9
239000000845 maltitol Substances 0.000 claims description 9
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 9
229940035436 maltitol Drugs 0.000 claims description 9
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 8
239000004386 Erythritol Substances 0.000 claims description 8
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 8
229930091371 Fructose Natural products 0.000 claims description 8
239000005715 Fructose Substances 0.000 claims description 8
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 8
229930006000 Sucrose Natural products 0.000 claims description 8
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
235000019414 erythritol Nutrition 0.000 claims description 8
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 8
229940009714 erythritol Drugs 0.000 claims description 8
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 8
239000005720 sucrose Substances 0.000 claims description 8
239000000811 xylitol Substances 0.000 claims description 8
235000010447 xylitol Nutrition 0.000 claims description 8
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
229960002675 xylitol Drugs 0.000 claims description 8
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 7
239000000832 lactitol Substances 0.000 claims description 6
235000010448 lactitol Nutrition 0.000 claims description 6
VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims description 6
229960003451 lactitol Drugs 0.000 claims description 6
229960002920 sorbitol Drugs 0.000 claims description 6
238000003780 insertion Methods 0.000 claims description 5
230000037431 insertion Effects 0.000 claims description 5
229960002737 fructose Drugs 0.000 claims description 4
229960001031 glucose Drugs 0.000 claims description 4
229960002160 maltose Drugs 0.000 claims description 4
229960004793 sucrose Drugs 0.000 claims description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 39
230000000694 effects Effects 0.000 abstract description 12
239000000126 substance Substances 0.000 abstract description 11
229920002678 cellulose Polymers 0.000 abstract description 6
239000001913 cellulose Substances 0.000 abstract description 6
235000010980 cellulose Nutrition 0.000 abstract description 6
235000013399 edible fruits Nutrition 0.000 abstract description 3
244000134552 Plantago ovata Species 0.000 abstract description 2
235000003421 Plantago ovata Nutrition 0.000 abstract description 2
239000009223 Psyllium Substances 0.000 abstract 1
AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 abstract 1
235000013305 food Nutrition 0.000 abstract 1
229940070687 psyllium Drugs 0.000 abstract 1
235000019504 cigarettes Nutrition 0.000 description 44
150000004804 polysaccharides Chemical class 0.000 description 44
241000596504 Tamarindus Species 0.000 description 42
230000002829 reductive effect Effects 0.000 description 16
241000208125 Nicotiana Species 0.000 description 15
235000002637 Nicotiana tabacum Nutrition 0.000 description 15
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
239000000243 solution Substances 0.000 description 15
238000011156 evaluation Methods 0.000 description 14
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
VMBCEJXTYHMTMM-UHFFFAOYSA-N F.F.I Chemical compound F.F.I VMBCEJXTYHMTMM-UHFFFAOYSA-N 0.000 description 12
238000005259 measurement Methods 0.000 description 11
239000001509 sodium citrate Substances 0.000 description 11
238000003756 stirring Methods 0.000 description 11
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 11
229940038773 trisodium citrate Drugs 0.000 description 11
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
239000012488 sample solution Substances 0.000 description 9
239000007864 aqueous solution Substances 0.000 description 8
235000000346 sugar Nutrition 0.000 description 8
235000010491 tara gum Nutrition 0.000 description 8
239000000213 tara gum Substances 0.000 description 8
206010057852 Nicotine dependence Diseases 0.000 description 7
208000025569 Tobacco Use disease Diseases 0.000 description 7
239000002253 acid Substances 0.000 description 7
238000011088 calibration curve Methods 0.000 description 7
239000000843 powder Substances 0.000 description 7
235000006200 Glycyrrhiza glabra Nutrition 0.000 description 6
244000303040 Glycyrrhiza glabra Species 0.000 description 6
229960005070 ascorbic acid Drugs 0.000 description 6
239000003638 chemical reducing agent Substances 0.000 description 6
230000035515 penetration Effects 0.000 description 6
239000002904 solvent Substances 0.000 description 6
150000008163 sugars Chemical class 0.000 description 6
RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 6
WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 5
239000004471 Glycine Substances 0.000 description 5
239000002211 L-ascorbic acid Substances 0.000 description 5
235000000069 L-ascorbic acid Nutrition 0.000 description 5
235000015165 citric acid Nutrition 0.000 description 5
238000000605 extraction Methods 0.000 description 5
239000007789 gas Substances 0.000 description 5
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 5
238000010438 heat treatment Methods 0.000 description 5
235000011477 liquorice Nutrition 0.000 description 5
238000002156 mixing Methods 0.000 description 5
238000004806 packaging method and process Methods 0.000 description 5
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 5
235000010234 sodium benzoate Nutrition 0.000 description 5
239000004299 sodium benzoate Substances 0.000 description 5
235000010469 Glycine max Nutrition 0.000 description 4
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 4
239000000945 filler Substances 0.000 description 4
-1 hydroxypropylmethylene, carboxymethyl Chemical group 0.000 description 4
229920001542 oligosaccharide Polymers 0.000 description 4
150000002482 oligosaccharides Chemical class 0.000 description 4
239000000047 product Substances 0.000 description 4
230000000717 retained effect Effects 0.000 description 4
239000012086 standard solution Substances 0.000 description 4
230000008719 thickening Effects 0.000 description 4
235000013912 Ceratonia siliqua Nutrition 0.000 description 3
240000008886 Ceratonia siliqua Species 0.000 description 3
235000005979 Citrus limon Nutrition 0.000 description 3
244000131522 Citrus pyriformis Species 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
229940011037 anethole Drugs 0.000 description 3
230000002238 attenuated effect Effects 0.000 description 3
230000002255 enzymatic effect Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
238000001764 infiltration Methods 0.000 description 3
230000008595 infiltration Effects 0.000 description 3
150000002772 monosaccharides Chemical class 0.000 description 3
RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 3
230000007903 penetration ability Effects 0.000 description 3
WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
229920002148 Gellan gum Polymers 0.000 description 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
244000068988 Glycine max Species 0.000 description 2
229920000569 Gum karaya Polymers 0.000 description 2
244000025221 Humulus lupulus Species 0.000 description 2
235000008694 Humulus lupulus Nutrition 0.000 description 2
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
244000062730 Melissa officinalis Species 0.000 description 2
229920000881 Modified starch Polymers 0.000 description 2
239000004368 Modified starch Substances 0.000 description 2
241000934878 Sterculia Species 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
239000001361 adipic acid Substances 0.000 description 2
235000011037 adipic acid Nutrition 0.000 description 2
IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 2
235000010443 alginic acid Nutrition 0.000 description 2
229920000615 alginic acid Polymers 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
238000013459 approach Methods 0.000 description 2
239000012159 carrier gas Substances 0.000 description 2
UQWIHFJXDRNUDP-UHFFFAOYSA-N chembl1206007 Chemical compound COC1=CC(S(O)(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S(O)(=O)=O)=CC=C12 UQWIHFJXDRNUDP-UHFFFAOYSA-N 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
150000002016 disaccharides Chemical class 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000012530 fluid Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
238000004817 gas chromatography Methods 0.000 description 2
235000010492 gellan gum Nutrition 0.000 description 2
239000000216 gellan gum Substances 0.000 description 2
239000011521 glass Substances 0.000 description 2
239000001307 helium Substances 0.000 description 2
229910052734 helium Inorganic materials 0.000 description 2
SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 2
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 2
239000001863 hydroxypropyl cellulose Substances 0.000 description 2
239000004615 ingredient Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000005342 ion exchange Methods 0.000 description 2
235000010494 karaya gum Nutrition 0.000 description 2
239000000231 karaya gum Substances 0.000 description 2
229940039371 karaya gum Drugs 0.000 description 2
239000000463 material Substances 0.000 description 2
235000019426 modified starch Nutrition 0.000 description 2
239000002245 particle Substances 0.000 description 2
238000009928 pasteurization Methods 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
238000002791 soaking Methods 0.000 description 2
PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
KSCPIFPNRGZFRV-UHFFFAOYSA-N 2-[4-[[2-(4-chlorophenyl)-5-methoxyphenyl]methoxy]phenyl]-1-cyclohexylbenzimidazole-5-carboxylic acid Chemical compound C=1C(OC)=CC=C(C=2C=CC(Cl)=CC=2)C=1COC(C=C1)=CC=C1C1=NC2=CC(C(O)=O)=CC=C2N1C1CCCCC1 KSCPIFPNRGZFRV-UHFFFAOYSA-N 0.000 description 1
QIGJYVCQYDKYDW-UHFFFAOYSA-N 3-O-alpha-D-mannopyranosyl-D-mannopyranose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(CO)OC(O)C1O QIGJYVCQYDKYDW-UHFFFAOYSA-N 0.000 description 1
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
239000004925 Acrylic resin Substances 0.000 description 1
244000247901 Actinidia callosa Species 0.000 description 1
235000000433 Actinidia callosa Nutrition 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
240000007474 Aloe arborescens Species 0.000 description 1
235000004509 Aloe arborescens Nutrition 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
240000004178 Anthoxanthum odoratum Species 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
241000223678 Aureobasidium pullulans Species 0.000 description 1
244000063299 Bacillus subtilis Species 0.000 description 1
235000014469 Bacillus subtilis Nutrition 0.000 description 1
235000016068 Berberis vulgaris Nutrition 0.000 description 1
241000335053 Beta vulgaris Species 0.000 description 1
UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
239000001884 Cassia gum Substances 0.000 description 1
240000003538 Chamaemelum nobile Species 0.000 description 1
235000007866 Chamaemelum nobile Nutrition 0.000 description 1
241000206575 Chondrus crispus Species 0.000 description 1
244000007835 Cyamopsis tetragonoloba Species 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
YTBSYETUWUMLBZ-UHFFFAOYSA-N D-Erythrose Natural products OCC(O)C(O)C=O YTBSYETUWUMLBZ-UHFFFAOYSA-N 0.000 description 1
YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 1
WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
206010011878 Deafness Diseases 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
MQIUGAXCHLFZKX-UHFFFAOYSA-N Di-n-octyl phthalate Natural products CCCCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCCC MQIUGAXCHLFZKX-UHFFFAOYSA-N 0.000 description 1
206010013975 Dyspnoeas Diseases 0.000 description 1
244000133098 Echinacea angustifolia Species 0.000 description 1
206010056474 Erythrosis Diseases 0.000 description 1
229920002581 Glucomannan Polymers 0.000 description 1
235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
235000017367 Guainella Nutrition 0.000 description 1
241001507103 Hypnea japonica Species 0.000 description 1
AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241000115676 Macrophomopsis Species 0.000 description 1
244000070406 Malus silvestris Species 0.000 description 1
235000007232 Matricaria chamomilla Nutrition 0.000 description 1
235000010654 Melissa officinalis Nutrition 0.000 description 1
208000001705 Mouth breathing Diseases 0.000 description 1
240000002778 Neonotonia wightii Species 0.000 description 1
229920002230 Pectic acid Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004376 Sucralose Substances 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
241001052560 Thallis Species 0.000 description 1
241000589636 Xanthomonas campestris Species 0.000 description 1
244000273928 Zingiber officinale Species 0.000 description 1
235000006886 Zingiber officinale Nutrition 0.000 description 1
ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000002535 acidifier Substances 0.000 description 1
229940095602 acidifiers Drugs 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
230000001070 adhesive effect Effects 0.000 description 1
239000008272 agar Substances 0.000 description 1
229940072056 alginate Drugs 0.000 description 1
239000000783 alginic acid Substances 0.000 description 1
229960001126 alginic acid Drugs 0.000 description 1
150000004781 alginic acids Chemical class 0.000 description 1
FYGDTMLNYKFZSV-DZOUCCHMSA-N alpha-D-Glcp-(1->4)-alpha-D-Glcp-(1->4)-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O[C@@H]2[C@H](OC(O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-DZOUCCHMSA-N 0.000 description 1
WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
235000001014 amino acid Nutrition 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
235000010208 anthocyanin Nutrition 0.000 description 1
229930002877 anthocyanin Natural products 0.000 description 1
239000004410 anthocyanin Substances 0.000 description 1
150000004636 anthocyanins Chemical class 0.000 description 1
239000003963 antioxidant agent Substances 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
235000021016 apples Nutrition 0.000 description 1
239000003125 aqueous solvent Substances 0.000 description 1
PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
BEWFIPLBFJGWSR-AONZOJHOSA-N butyl (z,12r)-12-acetyloxyoctadec-9-enoate Chemical group CCCCCC[C@@H](OC(C)=O)C\C=C/CCCCCCCC(=O)OCCCC BEWFIPLBFJGWSR-AONZOJHOSA-N 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
229910002091 carbon monoxide Inorganic materials 0.000 description 1
231100000315 carcinogenic Toxicity 0.000 description 1
235000019318 cassia gum Nutrition 0.000 description 1
ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
235000005487 catechin Nutrition 0.000 description 1
229920002301 cellulose acetate Polymers 0.000 description 1
229920003086 cellulose ether Polymers 0.000 description 1
238000004587 chromatography analysis Methods 0.000 description 1
229950001002 cianidanol Drugs 0.000 description 1
235000019506 cigar Nutrition 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
238000010586 diagram Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
235000015872 dietary supplement Nutrition 0.000 description 1
235000014134 echinacea Nutrition 0.000 description 1
230000007515 enzymatic degradation Effects 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000011152 fibreglass Substances 0.000 description 1
239000012847 fine chemical Substances 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
235000013373 food additive Nutrition 0.000 description 1
239000002778 food additive Substances 0.000 description 1
235000002864 food coloring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
229940107187 fructooligosaccharide Drugs 0.000 description 1
235000021255 galacto-oligosaccharides Nutrition 0.000 description 1
150000003271 galactooligosaccharides Chemical class 0.000 description 1
229930182830 galactose Natural products 0.000 description 1
235000008397 ginger Nutrition 0.000 description 1
229940046240 glucomannan Drugs 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229940094952 green tea extract Drugs 0.000 description 1
235000020688 green tea extract Nutrition 0.000 description 1
229940093915 gynecological organic acid Drugs 0.000 description 1
229940059442 hemicellulase Drugs 0.000 description 1
108010002430 hemicellulase Proteins 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003434 inspiratory effect Effects 0.000 description 1
GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 description 1
CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
235000008696 isoflavones Nutrition 0.000 description 1
DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229940010454 licorice Drugs 0.000 description 1
230000007774 longterm Effects 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000006996 mental state Effects 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000012046 mixed solvent Substances 0.000 description 1
QIGJYVCQYDKYDW-NSYYTRPSSA-N nigerose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-NSYYTRPSSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
235000013615 non-nutritive sweetener Nutrition 0.000 description 1
239000004745 nonwoven fabric Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000000123 paper Substances 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920000728 polyester Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000010318 polygalacturonic acid Substances 0.000 description 1
150000008442 polyphenolic compounds Chemical class 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
239000004302 potassium sorbate Substances 0.000 description 1
235000010241 potassium sorbate Nutrition 0.000 description 1
229940069338 potassium sorbate Drugs 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
230000001007 puffing effect Effects 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
230000035807 sensation Effects 0.000 description 1
235000019615 sensations Nutrition 0.000 description 1
235000020374 simple syrup Nutrition 0.000 description 1
230000005586 smoking cessation Effects 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019408 sucralose Nutrition 0.000 description 1
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000013616 tea Nutrition 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
235000019263 trisodium citrate Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000003643 water by type Substances 0.000 description 1

Images

Classifications

- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F7/00—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders
- A24F7/04—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders with smoke filters

Landscapes

Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Cigarettes, Filters, And Manufacturing Of Filters (AREA)
Medicinal Preparation (AREA)

RU2006133378/12A 2004-02-19 2005-02-18 Задерживающий никотин агент и способ снижения содержания никотина RU2363361C2 (ru)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2004043610		2004-02-19
JP2004-043610		2004-02-19
JP2004136448		2004-04-30
JP2004-136448		2004-04-30

Publications (2)

Publication Number	Publication Date
RU2006133378A RU2006133378A (ru)	2008-03-27
RU2363361C2 true RU2363361C2 (ru)	2009-08-10

Family

ID=34889339

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2006133378/12A RU2363361C2 (ru)	2004-02-19	2005-02-18	Задерживающий никотин агент и способ снижения содержания никотина

Country Status (6)

Country	Link
EP (1)	EP1723860A4 (fr)
JP (1)	JP3882125B2 (fr)
KR (1)	KR20070005634A (fr)
MX (1)	MXPA06009506A (fr)
RU (1)	RU2363361C2 (fr)
WO (1)	WO2005079609A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2767511C2 (ru) *	2020-07-13	2022-03-17	Бритиш Америкэн Тобэкко (Инвестментс) Лимитед	Вставной фильтрующий элемент для нагреваемого без горения продукта
US11678694B2 (en)	2011-06-27	2023-06-20	Nicoventures Trading Limited	Smoking article filter and insertable filter unit therefor

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102216526A (zh) *	2008-11-12	2011-10-12	日本烟草产业株式会社	低延烧性香烟用卷纸
CN102488495B (zh) *	2011-12-19	2014-09-10	陈心广	数字化智能尼古丁依赖性测评方法
JP2017077181A (ja) *	2014-02-14	2017-04-27	日本たばこ産業株式会社	フィルター付シガレット
CN116250483B (zh)	2015-06-26	2024-01-30	奥驰亚客户服务公司	用于生产烟草植物的组合物和方法以及具有改变的生物碱含量的制品
US20180228203A1 (en) *	2017-02-16	2018-08-16	Altria Client Services Llc	Pre-vapor formulation for formation of organic acids during operation of an e-vaping device
JP7212452B2 (ja) *	2018-02-23	2023-01-25	ＦｕｔｕｒｅＴｅｃｈｎｏｌｏｇｙ株式会社	非タバコ植物組成物の製造方法、電子タバコ用充填物の製造方法、電子タバコ用充填物及びそれを用いた電子タバコカートリッジ

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2324247A1 (fr) *	1975-09-19	1977-04-15	Daicel Ltd	Filtre a tabac
RU2010546C1 (ru) *	1992-04-22	1994-04-15	Товарищество с ограниченной ответственностью "Сфинкс"	Фильтр для сигарет
EP0632968A2 (fr) *	1993-07-09	1995-01-11	Rhone-Poulenc Rhodia Aktiengesellschaft	Cordon filtrant et son procédé de fabrication ainsi qu'un filtre pour fumée de tabac et son procédé de fabrication
RU2113810C1 (ru) *	1996-09-10	1998-06-27	Институт биохимической физики РАН	Фильтр для сигарет
RU2123271C1 (ru) *	1994-06-27	1998-12-20	Ставридис Иоаннис	Способ изготовления фильтра для табачного дыма, фильтр, сигарета, способ фильтрования табачного дыма

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2310396A1 (fr) *	1975-05-05	1976-12-03	Seita	Perfectionnements aux colles pour l'industrie du tabac
JPH03219861A (ja) *	1990-01-25	1991-09-27	Daicel Chem Ind Ltd	たばこ煙用フィルター
JPH0416177A (ja) *	1990-05-09	1992-01-21	Daicel Chem Ind Ltd	たばこ煙用フィルター
JP3675523B2 (ja) *	1995-08-07	2005-07-27	ダイセル化学工業株式会社	タバコフィルター
JPH09322748A (ja) *	1996-06-04	1997-12-16	Seiichi Kitabayashi	フィルター筒部付き紙巻き煙草のフィルター筒部または普通の煙草を差し込むフィルターパイプのフィルター筒部
US6544573B1 (en) *	1999-08-16	2003-04-08	Lipton, Division Of Conopco, Inc.	Gum combination for liquid condiment systems
DE60131862D1 (de) *	2000-09-20	2008-01-24	Nycomed Pharma As	Herstellung von vitaminemulsionen und konzentrate davon

2005
- 2005-02-18 MX MXPA06009506A patent/MXPA06009506A/es unknown
- 2005-02-18 EP EP05719318A patent/EP1723860A4/fr not_active Withdrawn
- 2005-02-18 JP JP2006519353A patent/JP3882125B2/ja not_active Expired - Fee Related
- 2005-02-18 RU RU2006133378/12A patent/RU2363361C2/ru active
- 2005-02-18 KR KR1020067019302A patent/KR20070005634A/ko not_active Withdrawn
- 2005-02-18 WO PCT/JP2005/002649 patent/WO2005079609A1/fr not_active Ceased

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2324247A1 (fr) *	1975-09-19	1977-04-15	Daicel Ltd	Filtre a tabac
RU2010546C1 (ru) *	1992-04-22	1994-04-15	Товарищество с ограниченной ответственностью "Сфинкс"	Фильтр для сигарет
EP0632968A2 (fr) *	1993-07-09	1995-01-11	Rhone-Poulenc Rhodia Aktiengesellschaft	Cordon filtrant et son procédé de fabrication ainsi qu'un filtre pour fumée de tabac et son procédé de fabrication
RU2123271C1 (ru) *	1994-06-27	1998-12-20	Ставридис Иоаннис	Способ изготовления фильтра для табачного дыма, фильтр, сигарета, способ фильтрования табачного дыма
RU2113810C1 (ru) *	1996-09-10	1998-06-27	Институт биохимической физики РАН	Фильтр для сигарет

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US11678694B2 (en)	2011-06-27	2023-06-20	Nicoventures Trading Limited	Smoking article filter and insertable filter unit therefor
US12295408B2 (en)	2011-06-27	2025-05-13	Nicoventures Trading Limited	Smoking article filter and insertable filter unit therefor
RU2767511C2 (ru) *	2020-07-13	2022-03-17	Бритиш Америкэн Тобэкко (Инвестментс) Лимитед	Вставной фильтрующий элемент для нагреваемого без горения продукта

Also Published As

Publication number	Publication date
RU2006133378A (ru)	2008-03-27
EP1723860A1 (fr)	2006-11-22
EP1723860A4 (fr)	2008-02-27
JPWO2005079609A1 (ja)	2007-10-25
KR20070005634A (ko)	2007-01-10
JP3882125B2 (ja)	2007-02-14
MXPA06009506A (es)	2007-03-26
WO2005079609A1 (fr)	2005-09-01

Publication	Publication Date	Title
CN100566610C (zh)	2009-12-09	尼古丁降低剂和尼古丁的降低方法
JP7623999B2 (ja)	2025-01-29	ニコチンパウチ
Baker et al.	2004	The effect of tobacco ingredients on smoke chemistry. Part II: casing ingredients
JP6047697B2 (ja)	2016-12-21	遊離塩形態のニコチンを含有するパウチ
US20060254606A1 (en)	2006-11-16	Novel smoking composition
AU2004269986A1 (en)	2005-03-17	Nicotine formulations and use thereof
EP3351121A1 (fr)	2018-07-25	Gel à fumer de narguilé sans tabac
EP3868222A1 (fr)	2021-08-25	Article sans fumée
US20220202071A1 (en)	2022-06-30	Smokeless article
RU2363361C2 (ru)	2009-08-10	Задерживающий никотин агент и способ снижения содержания никотина
CN101528199B (zh)	2013-05-29	改良的鼻烟组合物
JP2022520940A (ja)	2022-04-04	エアロゾル生成用の再構成カカオ材料
US7302954B1 (en)	2007-12-04	Cigarette filter comprising grape proanthocyanidin
US9060833B2 (en)	2015-06-23	Method of preparing flavored function specific toothpick
US20080011311A1 (en)	2008-01-17	Nicotine-Reducing Agent And Nicotine Reducing Method
US20050263165A1 (en)	2005-12-01	Tobacco leaf substitute
CN206197001U (zh)	2017-05-31	一种含有烟用固体甜味颗粒的卷烟嘴棒
CN112674384A (zh)	2021-04-20	降低烟气中有害物质的添加剂及其制备方法和应用
US20040094170A1 (en)	2004-05-20	Nicotine free cigarette substitute
EP3868221A1 (fr)	2021-08-25	Article sans fumée
CN117223881A (zh)	2023-12-15	一种含游离态尼古丁及尼古丁盐的口含尼古丁制品
EP4201229B1 (fr)	2024-06-19	Procédé de préparation d'une composition consommable de narguilé
EP3868223A1 (fr)	2021-08-25	Article sans fumée
RU2832481C1 (ru)	2024-12-24	Бездымное изделие, содержащее бамбуковые волокна с дозированным количеством никотина, применение таких волокон, способ изготовления указанного изделия и комплект, содержащий бездымное изделие
EP4505883A1 (fr)	2025-02-12	Procédé de fabrication d'un article sans fumée