RU2351310C2 - Compositions for skin care and methods - Google Patents

Abstract

FIELD: cosmetology.

SUBSTANCE: invention relates to cosmetology, namely to composition for skin care suitable for local application on skin. The composition contains from 1.5 to 4 wt % of. salicylic acid or its salt, and from, at least, 1 wt % to less than 3 wt % of. hydrogen peroxide where the composition includes the system of dissolvents containing water in admixture with C1-6 alcohol in quality with-solvent and is presented in the form of a solution, dispersion or gel; or in the form of emulsion and, besides, the composition is free from other therapeutic agents chosen from the group, consisting of antimicrobic agents, antibacterial agents, antiviral agents, antimicotic agents, anthelminthic agents and antiinflammatory agents.

EFFECT: invention provides creation of effective composition for treatment of comedones, and simplification of drawing up of compounding and process of manufacture at the expense of decrease of active ingredients amount.

17 cl, 10 ex

Description

The present invention relates to compositions for skin care, in particular to compositions effective in the treatment of acne vulgaris, as well as to methods of treating skin that include applying said compositions.

Acne vulgaris (acne) is a chronic inflammatory condition of the sebaceous elements of the skin, which is especially common in adolescents. The condition usually causes the formation of acne, red papules, pustules and sometimes cysts on the skin. This gives the skin an unsightly appearance and, in addition, if acne is not treated, they can lead to scarring of the skin. The main causes of acne are believed to be increased secretion of the sebaceous glands, increased presence of Propionibacterium acne (P.acne) , obstruction of the sebaceous duct, and the appearance of inflammation.

Salicylic acid is known to be effective in treating acne. It is a local keratolytic agent that works by dissolving an intercellular binding substance that holds epidermal cells together. Salicylic acid is used in a number of over-the-counter acne treatments.

It has now been found that improved topical acne treatment can be achieved by combining salicylic acid with hydrogen peroxide.

Hydrogen peroxide is also used in cleansing compositions for topical application to the skin. However, hydrogen peroxide is usually considered only as a disinfectant and is not used as an active agent in the treatment of acne.

Topical skin care products containing salicylic acid and hydrogen peroxide are described, but in such cases, salicylic acid and hydrogen peroxide are only auxiliary substances for other therapeutic agents. For example, the following related patents and US patent applications: US 6071541, US 6296880, US 6383523, US 2002/0172719, all relate to compositions for skin care in the case of a number of dermatological conditions containing hydrogen peroxide and an acid component (moreover, salicylic acid is one from examples of such an acid component) in combination with an antimicrobial agent, optionally with an anti-inflammatory agent. An antimicrobial agent is an antibacterial compound, an antiviral agent, an antifungal agent, or an anthelmintic agent. In addition, the application US 2002/0054918 relates to a local anti-inflammatory agent containing hydrogen peroxide in an amount that cleanses the skin, a moisturizing agent and an anti-inflammatory agent, optionally with an acidic exfoliator (such as salicylic acid). In the compositions described above, the acid component, as indicated, is present in an amount sufficient to exfoliate, that is, to remove dead or dry skin cells from at least part of the skin, hydrogen peroxide is present in an amount sufficient to clean at least parts of the skin, and the antimicrobial agent inhibits the formation of microbes and can further reduce the presence of microbes that cause redness, inflammation and skin irritation.

Surprisingly, skin care compositions containing therapeutically effective concentrations of both salicylic acid and hydrogen peroxide have been found to be effective in treating acne without requiring the presence of either an antimicrobial or anti-inflammatory therapeutic agent. In particular, the combination of salicylic acid and hydrogen peroxide is believed to have valuable therapeutic properties in reducing the presence of P. acne on the skin, especially due to the oxidative effect of hydrogen peroxide.

Given the above prior art, the creation of an effective treatment for acne composition containing salicylic acid and hydrogen peroxide without antimicrobial and / or anti-inflammatory agent, is unexpected.

Moreover, reducing the number of active ingredients in the composition provides a significant advantage, as it facilitates the formulation and production processes. The combination of these two ingredients also allows you to get a wide variety of non-irritating, stable and cosmetically acceptable therapeutic compositions, including, but not limited to, compositions containing detergent systems. The combination also provides effective topical compositions that can be adapted to either hold onto the skin after application or rinse off after application.

Thus, in accordance with a first aspect of the invention, there is provided a skin care composition that is suitable for topical application to the skin, containing from 0.5 to 10 wt.% Salicylic acid or its salt and from 0.5 to 10 wt.% Peroxide hydrogen or a compound capable of forming hydrogen peroxide when used, wherein the composition essentially does not contain other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents, antifungal agents, antihelm the covariant agents and anti-inflammatory agents.

By the definition of "substantially free of other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents, antifungal agents, anthelmintic agents and anti-inflammatory agents" is meant that the composition does not contain an effective amount of these compounds. In the General case, this means that the composition will contain less than 0.01 wt.% Any of the specified compounds, more preferably less than 0.001 wt.%. Preferred compositions essentially do not contain any compound (other than salicylic acid and hydrogen peroxide), which is known to have a therapeutic effect in the treatment of acne or other dermatological conditions when applied topically to the skin. In other preferred compositions, specific classes of therapeutic agents that (with the exception of salicylic acid and hydrogen peroxide, to the extent to which any of these compounds fall into these classes) are absent in the composition in accordance with the invention, may be:

Antimicrobial or antibacterial compounds, in particular selected from the following compounds:

triclosan, neomycin, clindamycin, polymyxin, bacitracin, benzoyl peroxide, tetracyclines such as doxycycline or minocycline, sulfa drugs such as sulfacetamide, penicillins, cephalosporins such as cefalexin, and quinulflocin, such as lolofolcin, lomoloxin, or lolofoxin, such as lolofoxin, or loloflacin, such as loloflacin, or lofoloxin,

Antiviral compounds, in particular selected from acyclovir, tamvir and penciclovir;

Antifungal compounds, in particular selected from the following compounds:

farnesole, clotrimazole, ketoconazole, econazole, fluconazole, undecylenate calcium or zinc, undecylenic acid, butenafine hydrochloride, cyclopirox olaimine, miconazole nitrate, nystatin, salconazole and terbinafine hydrochloride.

Anti-inflammatory compounds, in particular selected from the following compounds:

steroidal agents selected from hydrocortisone, fluocinolone acetonide, chalcinonide, halobetasol propionate, clobetasol propionate, betamethasone dipropionate, betamethasone valerate and triamcinolone acetonide, and non-steroidal anti-inflammatory agents selected from etaloen , licorice extract, onion buttercup, Canadian willow, zinc and allantion roots;

Anthelmintic drugs, in particular metronidazole.

Compositions in accordance with the present invention essentially may not contain other therapeutic agents. Preferred compositions are substantially completely free of other therapeutic agents.

In preferred compositions, salicylic acid and hydrogen peroxide are the only active ingredients that have a therapeutic effect in the local treatment of acne.

In one embodiment of the present invention, salicylic acid and hydrogen peroxide are the only active ingredients in the composition.

Salicylic acid is preferably introduced into the composition in accordance with the present invention in the form of a free acid. However, the pH of the composition can usually be such that salicylic acid exists in the composition in dissociated form. Since the composition may also contain a cationic counterion, salicylic acid is subsequently believed to be present in salt form. Alternatively, salicylic acid may be incorporated into the composition in salt form, for example, as a salt with a Group I metal, for example, as sodium salicylate. As used herein, unless otherwise intended, any and all references to salicylic acid should be construed as encompassing the reference to acid and its dissociated forms and salts.

The concentration of salicylic acid in the composition in accordance with the invention is preferably at least 1.0 wt.%, More preferably at least 1.5% and most preferably at least 1.8 wt.%. The concentration of salicylic acid the acid is preferably less than 5 wt.%, more preferably less than 4 wt.%, and most preferably less than 3 wt.%. The concentration of salicylic acid may preferably fall in the range from 1.0 to 5.0 wt.%, More preferably from 1.5 to 4%, and most preferably from 1.8 to 3 wt.%. A particularly preferred concentration of salicylic acid is a concentration of 2 wt.%.

The composition most preferably contains hydrogen peroxide. Alternatively, the composition may comprise a compound which, when used, is capable of generating hydrogen peroxide. An example of a compound of the latter class is an adduct such as urea peroxide (carbamide peroxide).

The concentration of hydrogen peroxide in the composition in accordance with the present invention is preferably at least 1 wt.%. The concentration of hydrogen peroxide is preferably less than 5 wt.%, More preferably less than 3 wt.%, And most preferably less than 2 wt.%. The concentration of hydrogen peroxide, therefore, can fall in the range from 1 to 5 wt.%, More preferably from 1 to 3%, and most preferably from 1 to 2 wt.%.

Preferably, the ratio of salicylic acid to hydrogen peroxide in the composition in accordance with the present invention is in the range from 10: 1 to 1:10 mass parts, preferably from 5: 1 to 1: 2 mass parts, and most preferably from 2: 1 to 1: 1 mass parts.

Preferably, a composition is prepared with a pH in the range of 2.3 to 6.0, more preferably 2.5 to 5.0, and in particular with a pH in the range of 2.5 to 4.0, for example, approximately pH 3, 0 or with a pH of 3.5.

In many cases, it is preferable that the composition contains a chelating or binding agent, or another agent capable of complexing or otherwise interacting with metal ions present in the composition. Such agents can improve the stability of the composition and in particular can inhibit or prevent decomposition of hydrogen peroxide. Examples of chelating agents or binding agents are ethylenediaminetetraacetic acid and its salts, most often dipotassium and especially disodium salt. Another agent that can perform a similar function is sodium stannate.

The composition in accordance with the present invention can be obtained in various forms. However, the composition may also take the form of an aqueous or oily solution, or a dispersion or emulsion, or a gel. The emulsion may be an oil-in-water emulsion or a water-in-oil emulsion.

The oil phase of a water-in-oil emulsion or oil-in-water emulsion may, for example, contain:

a) hydrocarbon oils, such as paraffinic or mineral oils;

b) waxes such as beeswax or paraffin wax;

c) natural oils such as sunflower oil, kernel apricot oil, shea butter or jojoba oil;

d) silicone oils such as dimethicone, cyclomethicone or cetyl dimethicone;

e) fatty acid esters such as isopropyl palmitate, isopropyl myristate, dioctyl maleate, glyceryl oleate and cetostearyl isonanoate;

f) fatty alcohols such as cetyl alcohol or stearyl alcohol and mixtures thereof (e.g. cetyl stearyl alcohol);

g) polypropylene glycol or polyethylene glycol ethers, for example PPG-14 butyl ether; or

h) mixtures thereof, for example wax mixtures commercially available under the trade name Cutina (Henkel).

The emulsifiers used may be any emulsifiers known in the art for use in water-in-oil or oil-in-water emulsions. Known cosmetically acceptable emulsifiers are:

a) sesquioleates, such as sorbitol sesquioleate, commercially available, for example, under the trade name Arlacel 83 (ICI), or polyglyceryl-2-sesquioleate;

b) ethoxylated esters of derivatives of natural oils, such as a polyethoxylated ester of hydrogenated castor oil, commercially available, for example, under the trade name Arlacel 989 (ICI);

c) silicone emulsifiers, such as silicone polyols, commercially available, for example, under the trade name ABIL WS08 (Th. Goldschmidt AG);

d) anionic emulsifiers, such as fatty acid soaps, for example potassium stearate, and fatty acid sulfates, for example sodium cetostearyl sulfate, commercially available under the trade name Dehydag (Henkel);

e) ethoxylated fatty alcohols, for example emulsifiers, commercially available under the trade name Brij (ICI);

f) sorbitol esters, for example emulsifiers, commercially available under the trade name Span (ICI);

g) ethoxylated sorbitol esters, for example emulsifiers commercially available under the trade name Tween (ICI);

h) ethoxylated fatty acid esters, such as ethoxylated stearates, for example emulsifiers, commercially available under the trade name Myrj (ICI);

i) ethoxylated mono-, di- and triglycerides, for example emulsifiers, commercially available under the trade name Labrafil (Alfa Chem.);

j) non-ionic self-emulsifying waxes, for example wax, commercially available under the trade name Polawax (Croda);

k) ethoxylated fatty acids, for example emulsifiers, commercially available under the trade name Tefosa (Alfa Chem.);

l) methyl glucose esters such as polyglycerol-3-methyl glucose distearate, commercially available under the trade name Tegocare 450 (Degussa Goldschmidt); or

m) mixtures thereof.

The gels of the present invention may be aqueous or non-aqueous. Aqueous gels are preferred. The gel will contain a thickening agent or a gelling agent in order to obtain a sufficient gel viscosity. A number of thickeners can be used depending on the nature of the liquid carrier and the desired viscosity, and such thickeners are listed below. A particularly suitable thickening agent is a copolymer of acryloyl dimethyl tauric acid (or a salt thereof), preferably a copolymer of this monomer with another vinyl monomer. For example, the thickener is a copolymer of acryloyl dimethyl tauric acid salt with another vinyl monomer. The salt may be a group I alkali metal salt, but an ammonium salt is more preferred. Examples of suitable copolymer thickeners are:

i) Ammonium acryloyldimethyl taurate / vinylpyrrolidone copolymer, i.e. a copolymer of ammonium acryloyldimethyl taurate and vinylpyrrolidone (1-vinyl-2-pyrrolidone). This material is available under the trade name Aristoflex AVC, Clariant GmbH, Functional Chemicals Division, D-65840, Sulzbach, Germany;

ii) A copolymer of ammonium acryloyl dimethyl taurate / behenet-25-methacrylate, i.e. a copolymer of ammonium acryloyldimethyl taurate and behenet-25-methacrylate, the structure of which is represented by:

CH ₂ = CH (CH ₃ ) CO ₂ - (CH ₂ CH ₂ O) _n CH ₂ (CH ₂ ) ₂₀ CH ₃ ,

in which n is approximately 25. The named material is offered by Clariant GmbH under the trade name Aristoflex HMB;

iii) A copolymer of ammonium acryloyldimethyl taurate / vinylformamide, i.e. a copolymer of ammonium acryloyldimethyl taurate and vinylformamide Again, a suitable material is offered by Clariant GmbH under the trade name Aristoflex AVC-1.

Most preferably, the gel contains less than 10 wt.% A thickener, and more usually less than 5 wt.%. The amount of thickener will usually be more than 0.1 wt.% And more usually more than 0.5 wt.%. The amount of thickener in the gel is preferably in the range from 0.1 to 5 wt.%, More preferably from 0.5 to 5 wt.%. Typically, the amount of thickener will be less than 3 wt.%, For example, about 1 wt.% Or about 2 wt.%.

The gel in accordance with the present invention preferably has a viscosity of from about 50 to 20,000 MPa.s, more preferably from about 100 to 10,000 MPa.s. Viscosity can be measured using a Brookfield RVT viscometer equipped with spindle 4 rotating at 10 rpm after 2 minutes.

In the case of solutions or dispersions and gels, the composition will usually contain a solvent system or other continuous liquid phase. Such a system is preferably aqueous. However, mixed solvent systems can often be used with success. Such a mixed solvent system most preferably contains water in admixture with a co-solvent, most preferably a lower (e.g., C _1-6 ) alcohol, in particular ethanol.

Preferred aqueous systems contain water in an amount of at least 50 wt.%, More preferably at least 60 wt.%, And most preferably at least 70 wt.%, And in particular at least 80 wt.%. The upper limit of the water content will depend on the amount of other ingredients introduced into the composition, so that water can form the rest of the composition up to 100% of the composition. A typical maximum value is less than 90 wt.%, For example, 80 wt.% Or 85 wt.%.

Most preferably, the composition contains more than 5 wt.% Co-solvent and may include more than 10 wt.%, More than 20 wt.%, Or more than 30 wt.% Co-solvent. The amount of co-solvent present in the composition preferably does not exceed 50 wt.%. The amount of co-solvent, therefore, is preferably in the range from 5 to 50% by weight, more preferably from 10 to 50% by weight. In general, higher co-solvent ratios may be required in compositions containing higher proportions of ingredients (e.g., topically active ingredients discussed below) that are slightly soluble in water. When these ingredients are absent or their concentration is relatively low, the proportion of solvent may also be sometimes lower than in other embodiments of the invention, for example up to 20 wt.%.

Additionally, the composition may contain other active skin care agents that are well known in the art, and such agents may be effective in promoting the normal functioning of the skin. One group of preferred compositions comprises hydrolyzed milk protein to control sebum formation.

Additionally, the composition may include other components that are well known to specialists in this field. These include, for example:

a) emollients - ingredients that help maintain softness, smoothness and a pleasant appearance of the skin. Such ingredients may function due to their ability to remain on the surface of the skin or in the corneal layer and the ability to act as a lubricant, reducing or preventing peeling of the skin and improving the appearance of the skin. Examples of emollients are isopropyl myristate, fatty acid triglycerides, for example lauric triglyceride or caprine / caprylic triglyceride, and such a triglyceride is commercially available under the trade name Miglyol 810 (Huls UK), and Stearyl Ether 15 polypropylene glycol ether, known as Ether.

Particularly preferred emollients are polysiloxane compounds, in particular an agent known as cyclomethicone, i.e. cyclic dimethyl polysiloxane compounds, which correspond to the formula:

- (Si (CH ₃ ) ₂ ) _n -,

in which n has a value from 3 to 7.

b) humectants or moisturizers - ingredients designed to increase the water content of the upper layers of the skin. Examples of such ingredients are glycerin, 1,3-butylene glycol and propylene glycol;

c) emulsion stabilizing salts such as sodium chloride, sodium citrate or magnesium sulfate;

d) preservatives - ingredients that prevent or delay the growth of microbes and as a result protect the composition from spoilage. Examples of preservatives are propyl paraben, bronopol, sodium dehydroacetate;

f) chelating agents or binding agents (passivators) - ingredients that have the ability to form complexes with metal ions and inactivate them to prevent their negative effects on the stability or appearance of the composition described above. Examples of chelating agents are ethylenediaminetetraacetic acid and its salts, most often dipotassium salt and especially disodium or tetrasodium salt;

f) abrasives - ingredients used to help remove unwanted tissue or foreign materials from the skin when applying the composition. Abrasives usually contain finely divided solid particles. One example of a suitable abrasive is polyethylene balls;

g) pH adjusters - ingredients used to adjust the pH of a composition. Examples of pH adjusters are inorganic salts, such as sodium hydroxide, and organic bases, such as triethanolamine;

h) surfactants - in addition to being used as emulsifying agents, surfactants can be used in the compositions of the present invention as components of a cleansing action, foaming agents or solubilizing agents. Many of the emulsifying agents listed above can be used for these purposes, and other suitable surfactants will be readily apparent to those skilled in the art;

i) thickeners - ingredients designed to increase the viscosity of the composition. Thickeners that are water soluble or hydrophilic are preferred, and examples thereof are acrylic acid polymers, for example polymers commercially available under the trade name Carbopol (BF Goodrich), modified celluloses, for example hydroxypropyl methyl cellulose or hydroxyethyl cellulose, commercially available under the trade name Natrosol (Hercules ), alkylgalactomannans, available under the trade name N-Hance, xanthan gum, cetyl alcohol and sodium chloride.

j) perfumes and coloring matter.

Compositions in accordance with the present invention can be obtained by standard methods known in the art, for example, combining all the ingredients in one aqueous or non-aqueous phase. One aqueous phase may contain water-alcohol systems, optionally with a thickener. In the case of a two-phase composition (for example, oil and water), all or part of the oil-soluble ingredients can be combined to form an oil phase, and all or part of the water-soluble ingredients can be combined in the aqueous phase. This may be followed by a mixture of the oil and water phases together with the remaining ingredients to form an emulsion.

The composition in accordance with the present invention can be applied to the skin and left on the skin to obtain the desired therapeutic effect, or it can be applied and then washed off, for example, with water. The composition may be applied using fibrous material, for example, using cosmetic plates or wipes.

In accordance with another aspect of the invention, there is provided an article comprising a fibrous base, for example, a plate or tissue-shaped material, impregnated with a skin care composition of the present invention that contains salicylic acid or a salt thereof and hydrolyzed milk protein. The fibrous base can be used to apply the composition to the skin.

Preferably, said fibrous base is impregnated with a skin care composition in an amount in the range of 10 to 30 wt.%, Preferably 15 to 25 wt.%, And most preferably 18 to 22 wt.% Based on the fibrous base. Suitable fibrous substrates contain materials that include natural or synthetic fibers or mixtures thereof, for example cellulosic and / or cotton fibers. The fibrous base may be impregnated with a wet wipe composition that is suitable for direct use in applying the skin care composition of the present invention to a consumer’s skin. Alternatively, the fibrous base may be impregnated with a skin care composition and dried to form a dry wipe that must be moistened with, for example, water before it can be used.

In accordance with another aspect of the present invention, there is provided a method for the prophylactic or therapeutic treatment of acne, comprising topically applying to the patient's skin a skin care composition containing from 0.5 to 10 wt.% Salicylic acid or its salt and from 0.5 to 10% hydrogen peroxide or a compound capable of generating hydrogen peroxide when used, wherein the composition essentially does not contain other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents ntov, antifungal agents, anthelmintic agents and anti-inflammatory agents. In a preferred method, the composition is substantially free of other therapeutic agents.

It should be noted that the method in accordance with this aspect of the invention may be a therapeutic method, but often it will be mainly a cosmetic method, the purpose of which is to reduce or eliminate the apparently noticeable and often unsightly symptoms of acne vulgaris.

In another aspect, the invention provides the use of salicylic acid and hydrogen peroxide essentially without other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents, antifungal agents, anthelmintic agents and anti-inflammatory agents, for the prophylactic or therapeutic treatment of acne.

In yet another aspect, the invention provides the use of salicylic acid and hydrogen peroxide as the only active ingredients in the manufacture of a composition for the prophylactic or therapeutic treatment of acne by topical application of the composition to the skin.

The invention is described in more detail using the following examples for illustrative purposes only.

Example 1

Acne Cleansing Cream

Ingredients Tradename % wt./wt. PPG-14 butyl ether
Cetyl stearyl alcohol (80%) and PEG-20 stearate (20%)
Salicylic acid
Hydrogen peroxide (35% solution)
Perfume
Sodium hydroxide (30% solution)
Sodium stannate
Water Ucon Fluid AP
Polawax GP 200 8.00
7.5
2.00
4,286
0.10
0,050
0.005
up to 100%

Way

Salicylic acid is dissolved in butyl ether PPG-14 at a temperature of 70-75 ^C. To the mixture was added Polawax GP 200 to obtain the oil phase. The oil phase is then emulsified with water and sodium stannate at a temperature of 70-75 ° ^C. The resulting emulsion was cooled to room temperature and then mixed separately with hydrogen peroxide and perfume. Sodium hydroxide is added until a pH of 3 is obtained.

Example 2

Gel

Ingredients % wt./wt. Denatured alcohol
Propylene glycol
Butylene glycol
Hydroxypropyl methylcellulose
Salicylic acid
Hydrogen peroxide
Sodium citrate
Water twenty
eighteen
fifteen
2.5
2.0
1,5
0.3
up to 100%

Way

Hydroxypropyl methylcellulose is homogenized in water to form a thickened dispersion. A mixture of propylene glycol, butylene glycol, salicylic acid, previously dispersed in alcohol (den.), Is gently mixed in the aqueous phase with sodium citrate and hydrogen peroxide until a clear gel forms.

Example 3

Cleansing Cream (Scrub)

Ingredients % wt./wt. Cetyl betaine (30%)
PPG-15 stearyl ether
Sodium Lauryl Sulfate (28%)
Glycerol
Stearyl alcohol
Salicylic acid
Distearyldiammonium chloride
Hydrogen peroxide
Oxidized polyethylene
Cetyl alcohol
Steareth-21
Behenyl alcohol
PPG-30
Steareth-22
Perfume
Menthol
Disodium salt EDTUK
Water 6,667
four
3,571
3
2.88
2.00
1,5
1,5
1,0
0.8
0.5
0.32
0.25
0.25
0.2
0,075
0.01
up to 100%

Way

All ingredients except menthol, flavorings, oxidized polyethylene, sodium lauryl sulfate, cetyl betaine are mixed together at 70-75 ^{° C} to give a uniform mixture. The mixture is cooled to room temperature and then mixed with the remaining ingredients separately.

Example 4

Lotion

Ingredients % wt./wt. Alcohol (denatured)
Issoceteth-20
Salicylic acid
Hydrogen peroxide
Barbados Aloe Gel
Perfume
Triethanolamine
Disodium salt EDTUK
Imidazolidinyl urea
Methylparaben
Denatonium benzoate
Propylparaben
Water 37
2.86
2
1,5
0.495
0.3
0.18
0.005
0.004
0,00085
0,00023
0.00015
up to 100%

Way

All ingredients are mixed at room temperature to give a uniform composition.

The above described lotion can be saturated with plates of mixed natural and synthetic fibers in the amount of 95-110 ml per 65 plates (5 cm in diameter). The described lotion can also be used in ball switchgear.

Example 5

Cleansing composition for washing

Ingredients % wt./wt. Esterified sodium lauryl sulfate
Propylene glycol
Salicylic acid
Coconut Oil Glucoside
Hydrogen peroxide
Glyceryl oleate
Amidopropyl Betaine Coconut Oil Fatty Acids
Perfume
Sodium chloride
Polyquaternium-10
Water 11.9
3
2
1,5
1,5
1,5
1.4
0.5
0.27
0.2
up to 100%

Way

Salicylic acid is dispersed in propylene glycol, coconut oil glucoside and glyceryl oleate to give a lump free dispersion. The dispersion is then mixed with esterified sodium lauryl sulfate, which is previously mixed with water. The remaining ingredients are then mixed separately to formulate a composition.

Example 6

Impregnated Napkin Lotion

Ingredients % wt./wt. PPG-14 butyl ether
Glycerol
Cetyl stearyl isononanoate
Salicylic acid
Hydrogen peroxide
Ceteareth-20
Cetyl stearyl alcohol
Glyceryl stearate
Perfume
Cetyl palmitate
Ceteareth-12
Disodium salt EDTUK
Aloe Barbados Juice
Maltodextrin
Sodium hydroxide
Water 8.0
5.45
2.25
2.0
1,5
1,125
1,125
0.45
0.2
0.15
0.15
0.10
0,025
0,025
0.00012
up to 100%

Way

All ingredients except Barbados aloe, hydrogen peroxide and flavoring agents are mixed and heated to 90 ^C. The mixture was cooled to room temperature with stirring. The remaining ingredients are mixed into the mixture to obtain a homogeneous composition.

Example 7

Exfoliating napkin

Ingredients % wt./wt. PPG-14 butyl ether
Cetyl stearyl isononanoate
Salicylic acid
Ceteareth-20
Cetyl stearyl alcohol
Glyceryl stearate
Glycerol
Hydrolyzed Milk Protein
Hydrogen peroxide
Menthol
Disodium salt EDTUK
Cetyl palmitate
Cetyl stearyl palmitate
Perfume
Water 8.0
2.25
2.00
1.13
1.13
0.45
0.45
0.20
1,50
0.10
0.10
0.15
0.15
0.10
up to 100%

Way

All ingredients except of hydrolyzed milk protein, menthol, hydrogen peroxide and flavoring agents are mixed and heated to 90 ^C. The mixture was cooled to room temperature with stirring. The remaining ingredients are mixed into the mixture to obtain a homogeneous composition.

Example 8

Impregnated Lotion

Ingredients % wt./wt. Ethanol
Issoceteth-20
Salicylic acid
Hydrogen Peroxide (active 35%)
Hydrolyzed Milk Protein (Mixed with Propylene Glycol and Water)
Sodium hydroxide
Perfume
Disodium salt EDTUK
Water 37.00
3.00
2.00
4.29
0.20
0.20
0.10
0.005
up to 100%

Way

All ingredients are mixed at room temperature to form a homogeneous composition.

Example 9

Gel lotion

Ingredients % wt./wt. Ethanol
Glycerol
Issoceteth-20
Salicylic acid
Hydrogen peroxide (35%)
Ammonium Acryloyldimethyl Taurate Copolymer / Vinyl Pyrrolidone
Hydrolyzed Milk Protein
Sodium hydroxide (30%)
Perfume
Disodium salt EDTUK
Water 11.5
0.50
1.00
0.50
4.29
1,50
0.20
0.40
0.20
0.005
up to 100%

Way

Salicylic acid is dissolved in alcohol. With stirring, add water, glycerin and disodium salt of EDTUK. Then, with continuous homogenization, ammonium acryloyldimethyl taurate / vinylpyrrolidone copolymer is added. Finally, isoceteth-20, hydrogen peroxide, hydrolyzed milk protein and perfume are added. The pH is adjusted to 3 with sodium hydroxide.

Example 10

Impregnated Lotion

Ingredients % wt./wt. Sorbitol (70%)
Denatured Ethanol
Hydrogen peroxide
Issoceteth-20
Salicylic acid
Hydrolyzed Milk Protein
Sodium hydroxide (30%)
Perfume
Disodium salt EDTUK
Water 0.50
37.00
4.29
3.00
2.00
0.20
0.20
0.10
0.005
up to 100%

Way

All ingredients are mixed at room temperature to give a uniform composition.

Claims (17)

1. A skin care composition suitable for topical application to the skin, containing from 1.5 to 4 wt.% Salicylic acid or its salt, and from at least 1 wt.% To less than 3 wt.% Peroxide hydrogen where composition
a) includes a solvent system containing water mixed with C1-6 alcohol as a co-solvent and is presented in the form of a solution, dispersion or gel, or
b) in the form of an emulsion and, in addition, the composition is substantially free of other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents, antifungal agents, anthelmintic agents and anti-inflammatory agents. 2. The composition according to claim 1, which contains salicylic acid. 3. The composition according to claim 2, where the concentration of salicylic acid in the composition is at least 1.8 wt.%. 4. The composition according to claim 2, where the concentration of salicylic acid is less than 4 wt.%, Preferably less than 3 wt.%. 5. The composition according to claim 2, where the concentration of salicylic acid is in the range from 1.8 to 3 wt.%. 6. The composition according to claim 1, where the concentration of hydrogen peroxide in the composition is less than 2 wt.%. 7. The composition according to claim 1, where the concentration of hydrogen peroxide is in the range from 1 to 2 wt.% 8. The composition according to claim 1, where the ratio of salicylic acid to hydrogen peroxide is in the range from 2: 1 to 1: 1 parts by weight 9. The composition according to any one of the preceding paragraphs, where the pH of the composition is in the range from 2.3 to 6.0, more preferably from 2.5 to 5.0. 10. The composition according to claims 1-8, which further comprises a chelating or binding agent or other agent capable of forming complexes or other interaction with metal ions present in the composition. 11. The composition according to any one of claims 1 to 8, which further comprises a thickener. 12. The composition according to claim 11, where the thickener is a copolymer of acryloyl dimethyl tauric acid or its salt. 13. The composition according to claim 1, which is in the form of an emulsion. 14. The composition according to any one of claims 1 to 8, where the composition comprises a mixed solvent system containing water mixed with an alcohol co-solvent. 15. A method for the prophylactic or therapeutic treatment of acne, which includes topical application to the patient’s skin of a skin care composition containing from 1.5 to 4 wt.% Salicylic acid or its salt, and from at least 1 wt.% To less than 3 wt.% hydrogen peroxide, where the composition
a) includes a solvent system containing water mixed with C1-6 alcohol as a co-solvent and is presented in the form of a solution, dispersion or gel, or
b) in the form of an emulsion and, in addition, the composition is substantially free of other therapeutic agents selected from the group consisting of antimicrobial agents, antibacterial agents, antiviral agents, antifungal agents, anthelmintic agents and anti-inflammatory agents. 16. The method according to clause 15, which is a cosmetic method. 17. The method according to clause 15, which is a therapeutic method.