RU2350339C1 - Ve agaphonov's method of correction and optimisation of patients nutrition for improvement of organism and excess weight depression - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely to dietology and immunology, and can be used for organism improvement. The way includes definition of the maintenance of immunoglobulins of subclass IgG4-antitsl, a specific foodstuff to antigens in blood serum of the patient. At indicators above 7 mkg/ml, these products are excluded from food allowance. Products causing IgE-mediated hypersensitivity of 1 type from food allowance are also excluded. After that a daily food allowance of other products is made for the patient from references to use not more than 2-3 names of foodstuff per one time at their daily alternating.

EFFECT: method increases efficiency of improvement of an organism, including depression of excess weight at the expense of optimisation of a food and metabolism correction at elimination of negative influence of foodstuff on an organism in each specific case.

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Description

The invention relates to medicine, namely to nutrition, and can be used to select for each individual patient an adequate diet to optimize nutrition, improve the health of the body and reduce excess weight.

Known methods for correcting and optimizing the nutrition of patients, which are reduced to the exclusion of certain foods from the diet (RU 2174835, 2001; T.Yu. Repina. Clinical, immunological and allergic characteristics of patients with true food allergies and pseudo-allergic reactions to food. Abstract of candidate dissertation Moscow. 1997, p. 3-20).

However, the known methods do not take into account the individual characteristics of the body, including the degree of response to food allergens. As a rule, calorie content, the quality of the food product and its allergenicity are taken into account.

The closest in technical essence and the achieved result is a method of correction and optimization of patients ’nutrition for healing the body and reducing overweight, including the exclusion of certain foods from the diet, characterized in that the content of immunoglobulins of the IgG4 antibody-specific subclass is determined in the patient’s blood serum antigens from a particular food product, and when their content is more than 7 μg / ml, the corresponding product is excluded from the diet until IgG4 decreases, s etsifichnogo antigen of this product to a level of 7 pg / ml and below (RU 2185178, 2002).

The objective of the proposed method is to increase the efficiency of the method by developing an integrated approach in choosing a diet for each individual patient, which allows to optimize nutrition, eliminate the negative side effects of food on the body, improve it and reduce excess weight.

To achieve this goal in the method of correction and optimization of patients ’nutrition to improve the body’s health and reduce excess weight, which includes detecting the content of immunoglobulins of a subclass of IgG4 antibodies specific for food antigens in the patient’s blood serum above 7 μg / ml, and excluding them from the diet, according to the invention previously excluded from the diet foods that cause IgE-mediated hypersensitivity type 1, and after exclusion of foods that affect the excessive synthesis of immunoglobulins new IgE and IgG4 subclass, make up the daily diet of the rest of the products with the recommendation to consume no more than 2-3 items of food in 1 meal with their daily alternation.

The method is as follows. Take from a patient from the cubital vein 10-15 ml of blood. Blood is centrifuged at room temperature until serum is obtained. An enzyme immunoassay, radioimmunological or chemiluminescent method determines the quantitative or semi-quantitative content of specific IgE antibodies to antigens from various food products in the blood serum of a patient. The determination of specific IgE antibodies can be carried out using both commercial diagnostic kits and author's adaptations of the enzyme immunoassay, radioimmunological or chemiluminescent methods. In the study, both commercial antigens isolated from food products and proprietary developments of extracts from food products containing possibly a complete set of antigens from this product can be used. Various commercial and proprietary carriers (polymeric, polystyrene, cellulose) can also be used, to which antigens isolated from various food products are attached by various methods. Exclude from the patient’s diet products that cause IgE-mediated hypersensitivity of type 1 (all that cause the reaction of more than one cross by analogy with skin testing reactions).

Then the patient is re-taken from the ulnar vein 10-15 ml of blood. Blood serum is obtained by centrifugation. An enzyme immunoassay, radioimmunological or chemiluminescent method determines the quantitative content of specific IgG4 antibodies to antigens from various food products in the blood serum of a patient. The determination of specific IgG4 antibodies can be carried out using both commercial diagnostic kits and author's adaptations of the enzyme immunoassay, radioimmunological or chemiluminescent methods. In the study, both commercial antigens isolated from food products and proprietary developments of extracts from food products containing possibly a complete set of antigens from this product can be used. Various commercial and proprietary carriers (polymeric, polystyrene, cellulose) can also be used, to which antigens isolated from various food products are attached by various methods.

To obtain reliable results, the following conditions must be observed: cancellation of all medications 2 days before the examination, exclusion of alcohol intake within 2 days before the examination, re-examination of the patient’s blood 1, 5, 6 and 12 months after the first examination to adjust the diet.

When the content of IgG4 antibodies specific for antigens from one or another food product is more than 7 μg / ml, this product is excluded from the patient's diet for a period until the level of these antibodies decreases to the level of 7 μg / ml or lower.

Of the rest of the foodstuffs, a daily diet is made up with no more than 2-3 names of foods consumed per meal during daily alternation of foodstuffs.

An integrated approach to choosing a diet for each individual patient, the diet allows you to optimize nutrition, eliminate the negative side effects of food on the body, improve it and reduce excess weight.

The invention is illustrated by the following examples.

Example 1. Patient K., 38 years old. Complaints of overweight (135 kg with a growth of 175 cm), blood pressure of 150/100 mm / Hg, poor performance, fatigue and frequent SARS.

At the first stage, specific IgE antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, seafood, spices, herbs, milk and dairy products) are determined. Exclude from the diet of patients patients products that cause IgE-mediated hypersensitivity type 1. There were 15 such products. Next, specific IgG4 antibodies are determined for antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products). An increased content of IgG4 antibodies was detected above 7 μg / ml, in some cases up to 20 μg / ml for antigens from 71 food products. It is recommended that the patient exclude these products from the diet. In the diet of 150 tested products, 64 items are recommended for use. It is also recommended to use no more than 2-3 items of food at a time. During the day should be at least 5 meals. Foods should alternate every day (for example, foods consumed on Monday should be reintroduced into the diet no earlier than 1-2 days later.)

The duration of the diet course was 6 months with repeated examination and dietary adjustment 3 months after the start of the course. According to the results of the diet course, it was revealed: weight - 90 kg, blood pressure 120/80 mm / Hg, absence of acute respiratory viral infections for the entire period, high availability. At the end of the course, we carried out a control determination of the content of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products), including those that were excluded from the diet for the period diet. It was revealed that the levels of IgG4 antibodies to antigens of a number of products (23), excluded from the diet, returned to values of 7 μg / ml and lower. These foods have been returned to the diet.

Of the rest of the foodstuffs, a daily diet is made up with no more than 2-3 names of foods consumed per meal during daily alternation of foodstuffs.

It is recommended that the patient undergo a follow-up examination after 6-8 months.

Example 2. Patient I., 45 laid. Complaints of overweight (78 kg with a height of 169 cm), the presence of eczematous rashes on the hands, on the neck and hips from the age of 14, frequent headaches, painful periods, fast fatigue.

Exclude products that cause IgE-mediated type 1 hypersensitivity from the patient’s diet.

Determination of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products) is carried out. An increased content of IgG4 antibodies was detected above 7 μg / ml, in some cases up to 25 μg / ml for antigens from 69 food products. The patient is recommended to exclude these products from the diet. After 4 months, a re-determination of IgG4 antibodies was carried out. Based on the results of the analysis, some of the products that were previously excluded from the diet (15) were included again (the concentration of IgG4 antibodies decreased to 5 μg / ml and lower, and from the previously allowed consumption 6, the concentration of IgG4 antibodies increased above 7 mcg / ml. The total duration of the diet course was 9 months. According to the results of the diet course revealed: weight - 67 kg, clean skin, increased efficiency, lack of headaches, menstruation almost painless. the increase in the content of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products), including those that were excluded from the diet for the period of the diet. levels of IgG4 antibodies to antigens of a number of products excluded from the diet (31) returned to values of 7 μg / ml and lower.These food products were returned to the diet.

Of the rest of the foodstuffs, a daily diet is made up with no more than 2-3 names of foods consumed per meal during daily alternation of foodstuffs.

The patient is recommended to undergo a follow-up examination after 6 months.

Example 3. Patient L., a child of 5 months. Exudative diathesis, unstable stool, rickets of the II Art. On breastfeeding. In the mother of the child, specific IgG4 antibodies were determined for antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products).

Exclude products that cause IgE-mediated hypersensitivity type 1 from the child’s diet.

An increased content of IgG4 antibodies is detected above 7 μg / ml, in some cases up to 16 μg / ml to antigens from 54 food products. An elimination diet course was prescribed for 2 months. At the end of the course, the child has clean skin, normal stools, and rickets stopped. Lures were introduced based on the analysis of the content of IgG4 antibodies of the mother of the child. The child had no reactions to complementary foods.

Of the remaining complementary foods, the daily diet consists of not more than 2-3 items of food consumed per meal during their daily alternation. Upon further observation, there were no complaints.

Example 4. Patient N., 27 years old. Complaints of constant, rapid fatigability, dispersal, loss of appetite, constant runny nose, swelling of the nasopharynx for 7 years, headaches, frequent SARS.

Exclude from the diet of patients patients products that cause IgE-mediated hypersensitivity type 1.

Allergological studies did not reveal the presence of type 1 hypersensitivity (allergy history, skin testing, determination of allergen-specific IgE antibodies). For the last 4.5 years, he has been constantly using vasoconstrictor drugs in the nose.

Determination of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products) is carried out. An increased content of IgG4 antibodies was detected above 7 μg / ml, in some cases up to 20 μg / ml for antigens from 98 food products. It is recommended that the patient exclude these products from the diet. The duration of the diet was 4.5 months. According to the results of the diet course, it was revealed: nasopharyngeal swelling has passed, there are no runny nose, headaches have stopped, performance has increased, vasoconstrictor drugs are not used in the nose, and I have never had ARVI. At the end of the course, we carried out a control determination of the content of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products), including those that were excluded from the diet for the period diet. It was revealed that the levels of IgG4 antibodies to antigens of a number of products (65), excluded from the diet, returned to values of 7 μg / ml and lower. These foods have been returned to the diet.

Of the rest of the foodstuffs, a daily diet is made up with no more than 2-3 names of foods consumed per meal during daily alternation of foodstuffs.

It is recommended that the patient undergo a follow-up examination after 6 months.

Example 5. Patient M., 43 years old. Complaints of overweight (121 kg with an increase of 187 cm), unstable stools for 10 years, frequent (up to 10 times a year) SARS, sharp headaches (especially when the weather changes), a significant decrease in working capacity, long-term need (up to 12 hours) sleep.

Exclude from the diet of patients patients products that cause IgE-mediated hypersensitivity type 1.

The patient is tested for specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products). Based on the results of the analysis, a diet course is prescribed for 1 year with a correction every three months on the basis of analysis data to determine the content of specific IgG4 antibodies. According to the results of the diet course, it was revealed: weight decreased in a year to 94 kg, ARVI was not present in the last 9 months, headaches were absent, sleep decreased to 6-7 hours with normal performance. At the end of the course, a control determination of the content of specific IgG4 antibodies to antigens isolated from 150 food products (from various vegetables, fruits, meat, fish, spices, herbs, milk and dairy products) was carried out, including those that were excluded from the diet for the period diet. Diet adjusted. Some products (39 items) were returned to the diet. Further observation of weight gain was not observed.

Of the rest of the foodstuffs, a daily diet is made up with no more than 2-3 names of foods consumed per meal during daily alternation of foodstuffs.

It is recommended that the patient undergo a follow-up examination after 10 months.

Thus, the use of an integrated approach in choosing a diet for each individual patient allows you to optimize nutrition, eliminate the negative side effects of food on the body, improve it and reduce excess weight.

Claims (1)

A method for correcting and optimizing the nutrition of patients for healing the body and reducing excess weight, including detecting the content of immunoglobulins of a subclass of IgG4 antibodies specific for food antigens in the blood serum of a patient above 7 μg / ml, and excluding them from the diet, characterized in that exclude from the diet foods that cause IgE - mediated hypersensitivity of type 1, and after exclusion of foods that affect the excessive synthesis of immunoglobulins IgE and the IgG4 subclass, make up exact diet of the other products with the recommendation to eat at one time no more than 2-3 kinds of foods at their daily alternation.