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RU2344134C2 - 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов - Google Patents

1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов Download PDF

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Publication number
RU2344134C2
RU2344134C2 RU2007107408/04A RU2007107408A RU2344134C2 RU 2344134 C2 RU2344134 C2 RU 2344134C2 RU 2007107408/04 A RU2007107408/04 A RU 2007107408/04A RU 2007107408 A RU2007107408 A RU 2007107408A RU 2344134 C2 RU2344134 C2 RU 2344134C2
Authority
RU
Russia
Prior art keywords
ethyl
dipyridin
mixture
mmol
alkyl
Prior art date
Application number
RU2007107408/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2007107408A (ru
Inventor
Марк Т. БИЛОДО (US)
Марк Т. БИЛОДО
Чжицай У. (US)
Чжицай У.
Джон ХАРТНЕТТ (US)
Джон Хартнетт
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of RU2007107408A publication Critical patent/RU2007107408A/ru
Application granted granted Critical
Publication of RU2344134C2 publication Critical patent/RU2344134C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2007107408/04A 2004-07-29 2005-07-25 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов RU2344134C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59218104P 2004-07-29 2004-07-29
US60/592,181 2004-07-29

Publications (2)

Publication Number Publication Date
RU2007107408A RU2007107408A (ru) 2008-09-10
RU2344134C2 true RU2344134C2 (ru) 2009-01-20

Family

ID=35613661

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007107408/04A RU2344134C2 (ru) 2004-07-29 2005-07-25 1,1,2,2-тетра (гетеро) арилэтаны или 1,1,2-три (гетеро) арил-2-гетероциклилэтаны в качестве ингибиторов калиевых каналов

Country Status (15)

Country Link
KR (1) KR20070043985A (es)
AR (1) AR049847A1 (es)
BR (1) BRPI0513793A (es)
CR (1) CR8876A (es)
EC (1) ECSP077208A (es)
IL (1) IL180846A0 (es)
MA (1) MA28980B1 (es)
MX (1) MX2007001188A (es)
NO (1) NO20071107L (es)
PE (1) PE20060382A1 (es)
RU (1) RU2344134C2 (es)
TW (1) TW200607493A (es)
UA (1) UA88018C2 (es)
WO (1) WO2006028590A1 (es)
ZA (1) ZA200700477B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539398C2 (ru) * 2009-03-18 2015-01-20 Медикю Интернэшинал Инк. Трансдермальный фармацевтический препарат и введение тирофибана

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20180815T8 (hr) 2012-06-11 2019-02-08 Bristol-Myers Squibb Company Prolijekovi fosforamidne kiseline 5-[5-fenil-4-(piridin-2-ilmetilamino)hinazolin-2-il]piridin-3-sulfonamida

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU505369A3 (ru) * 1971-08-14 1976-02-28 Байер Аг., (Фирма) Способ получени эфиров 1-имидазолилметанфосфоновой кислоты
RU2257205C2 (ru) * 1999-10-27 2005-07-27 Авентис Фарма Дойчланд Гмбх Применение 2-имидазолилзамещенных карбинолов для получения лекарственного средства для лечения или профилактики заболеваний, обусловленных ишемическими состояниями

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE400551T1 (de) * 2002-01-04 2008-07-15 Neurosearch As Kaliumkanal-modulatoren

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU505369A3 (ru) * 1971-08-14 1976-02-28 Байер Аг., (Фирма) Способ получени эфиров 1-имидазолилметанфосфоновой кислоты
RU2257205C2 (ru) * 1999-10-27 2005-07-27 Авентис Фарма Дойчланд Гмбх Применение 2-имидазолилзамещенных карбинолов для получения лекарственного средства для лечения или профилактики заболеваний, обусловленных ишемическими состояниями

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STEEL P.J. et al. Coordination chemistry of di-2-pyridylmethane and related bridging ligands with silver …", Dalton transactions., no. 23, 2003, p.4505-4515. D′Alessandro, D.M. et all. Mono- and di-nuclear complexes of the ligands 3,4-di(2-pyridyl)-1,2,5-oxadiazole and 3,4-di(2-pyridyl)-1,2,5-thiadiazole; …). AUSTRALIAN JOURNAL OF CHEMISTRY. Vol.56, no. 7, 2003, pages 657-664. R. HABERL et al. 1,2-di-.alphy.-pyridyl-1,2-diphenylethane. MONATSHEFTE FUER CHEMIE. Vol.88, 1957, p.47-51. W.CZUBA. Effects of substituent groups on the rearrangement of 3-nitroaminopyridine derivatives. BULLETIN DE L′ACADEMIE POLONAISE DES SCIENCES. Vol.8, no. 6, 1960, p.281-284. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539398C2 (ru) * 2009-03-18 2015-01-20 Медикю Интернэшинал Инк. Трансдермальный фармацевтический препарат и введение тирофибана

Also Published As

Publication number Publication date
IL180846A0 (en) 2007-06-03
TW200607493A (en) 2006-03-01
PE20060382A1 (es) 2006-05-15
ECSP077208A (es) 2007-02-28
KR20070043985A (ko) 2007-04-26
BRPI0513793A (pt) 2008-05-13
NO20071107L (no) 2007-04-19
RU2007107408A (ru) 2008-09-10
AR049847A1 (es) 2006-09-06
CR8876A (es) 2007-08-28
ZA200700477B (en) 2009-08-26
MX2007001188A (es) 2007-03-21
WO2006028590A1 (en) 2006-03-16
UA88018C2 (ru) 2009-09-10
MA28980B1 (fr) 2007-11-01

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20100726