RU2238729C1 - Method for treatment of opisthorchiasis - Google Patents

Abstract

FIELD: medicine, infectious diseases, helminthology.

SUBSTANCE: invention can be used for treatment of patients with opisthorchiasis. On the background of vegetarian nutrition mainly method involves application of 2-4 anti-homotoxic agents taken among the following group: Hepar compositum, Hepeel, Nux vomica-Homaccord, Chelidonium-Homaccord, Duodenoheel, Leptandra compositum, Momordica compositum, Coenzyme compositum, Ubichinon compositum, Berberis- Homaccord and also enterosorbent and eubiotic agent taken in effective course doses. Praziquantel is used in effective number doses with intervals allowing affecting on different generations of opisthorchis cells in the course dose 2.4 g, not above. Invention promotes to attainment of high clinical and anti-parasitic effects in reducing dose of helminthicide agent.

EFFECT: improved treatment method.

7 cl, 2 tbl, 1 ex

Description

The invention relates to medicine, more specifically to infectious diseases, helminthology.

The generally accepted position in the treatment of opisthorchiasis is the desire to free the patient from the parasite in a short time by using significant doses of helminthicides. The improvement of therapy for many years was limited to the search for new, more effective helminthicidal drugs, and modifications to the schemes for their use.

So, there is a known method of treating chronic opisthorchiasis with chloxyl, which was used in the 60-80s of the XX century. Chloxyl was prescribed in various regimens for 3, 5 or 10 days at a course dose of 0.3 g per kg of body weight, the maximum allowable course dose was 25 g. The drug was taken 3 times a day 30 minutes after eating in milk.

During and after this therapy, patients often worsened (the appearance of nausea, epigastric pain, diarrhea, weakness, dizziness, rash, etc.), due, on the one hand, to the pronounced toxicity of the drug (in particular, the suppression of the activity of microsomal systems liver) and, on the other hand, increased endogenous intoxication and allergies as a result of the death of parasites in the body. In animal experiments, the nephro- and neurotoxic effects of chloxil and its adverse effect on the hematopoietic system were established (8).

Chloxil infects sexually mature individuals of opisthorchis and does not affect their larvae. The lack of effectiveness of chloroxyl therapy, confirmed by the resumption of the isolation of parasite eggs with feces and bile, determined the need for repeated courses, which also did not lead to the proper clinical effect (7). In patients treated with chloroxyl several times, especially in conditions of repeated infections, the most serious combined pathology of the liver and other organs was recorded (1). The result was a general opinion about the inadmissibility of more than 2-3 courses of chloxyl. Since the 80s, for the massive treatment of opisthorchiasis, chloroxyl has not been used due to its toxic properties.

From then until now, praziquantel (biltricide) has been the main drug in the treatment of opisthorchiasis. Recommended course doses range from 25 to 75 mg / kg of patient body weight, maximum - not more than 4800 mg. The most common treatment regimen is the use of praziquantel for one day (or night) in three doses at intervals of 6 hours in a total dose of 60 mg / kg of the patient’s body weight (2), which for patients weighing 50-80 kg is 3-4 , 8 g, respectively. One to two weeks before the appointment of praziquantel and within 2-3 weeks after its administration, pathogenetic therapy is carried out (diet No. 5; choleretic drugs; physiotherapeutic procedures that stimulate bile secretion) (prototype).

When taking praziquantel according to the prototype method, a significant part of patients may experience dizziness, feelings of intoxication, headache, drowsiness, dyspeptic symptoms (nausea, vomiting, abdominal pain, diarrhea, gastrointestinal bleeding, etc.), excessive sweating, allergic reactions (skin rashes, itching). As in the case of the use of chloxyl, these disorders are associated both with the toxic effect of the drug on the body, and with an increase in intoxication and allergies as a result of the death of opisthorchis. There are warnings about the dangers of praziquantel in patients with liver disease (6).

Praziquantel also affects sexually mature individuals of the parasite and its larvae. However, a complete release from opisthorchisis in most cases does not occur. Repeated treatment with praziquantel is known up to three times in a standard course dose with no clinical and helminthological efficacy (3). It has been experimentally proved in animals that with the incomplete helminthological effect of praziquantel therapy, a progression of the pathological process in the liver is observed (20).

Data are known that after treatment with chloroxyl or praziquantel, clinically significant improvement in the health of patients in the period from 9 to 12 months after the end of the course of treatment was observed only in 18.3%, improvement in 65.09%, no change in 15.36% , on the basis of which a combination chemotherapy regimen was proposed. Chloxyl was prescribed according to a 5-day schedule at the rate of 60 mg / kg body weight per day, but not more than 25 g per treatment course. On the 6th day in the morning, blind drainage was performed according to Demyanovich and intestinal irrigation, after which praziquantel at a dose of 60 mg / kg body weight was prescribed at 22 hours - 2-6 hours. Before and after etiotropic therapy, treatment was carried out, including choleretic drugs, physiotherapeutic procedures, diet No. 5, and often antibiotics (3). Obviously, such a combined treatment regimen will lead to even more pronounced toxic damage to the body and sensitization, although the formally noted frequency of side effects was not higher than that observed with one drug treatment. The helminthological effectiveness of this treatment was evaluated by the absence of parasite eggs in the feces and bile. Immediately after treatment, according to the authors, it amounted to 97.4%. In this case, the preservation of the pathology of various organs was noted (3).

SUMMARY OF THE INVENTION

The scientific basis of the proposed therapy is the well-known idea of opisthorchiasis as a persistent infection (invasion), where evolutionary strong biological mechanisms have developed for the long coexistence of the host and the parasite under conditions of mutual adaptation. In the natural focus of invasion, which is Western Siberia, under the prevailing traditions of the widespread use of river fish of the cyprinid family, the majority of indigenous people are infected in childhood and by the time the diagnosis of opisthorchiasis is established, the duration of invasion is estimated for years or, more often, decades. The emerging disease is the result of practically inevitable repeated infections and is characterized by damage to various organs and systems, which remains clinically hidden for a long time. Under conditions of prolonged invasion, both during single and repeated infections, different generations of the parasite coexist simultaneously in the affected body, which significantly differ in many properties - age, size, maturity, uterine structure, ability to produce eggs, activity of physiological processes, in particular the nature and intensity of nutrition, and, most importantly, according to the degree of exposure to the action of body protection factors and helminthicidal agents (3, 12, 13, 14, 15). The competitive relationships between the sexually mature forms determine the presence of generations with active metabolic processes (mature helminths) in the opisthorchis population, as well as latent (“dormant”, “inhibited”) generations, including those that remain in the form of larvae for some time (10, 11, 12, 19). This determines the impossibility of freeing the body from the parasite by any violent means - the use of even significant doses of helminthicidal agents in a short time. Aggressive repeated drug therapy of this kind is essentially toxic, immunosuppressive, which in a chronic disease over time leads to a gradual loss of the body's ability to recover (4, 21). Regardless of the nature of the clinical manifestations of the disease, the common leading components in its pathogenesis are deep endogenous intoxication, a state of dysbiosis, impaired coordination in the system of somatic regulation of organs and systems.

The essence of the present invention is to develop a holistic system of pathogenetic therapy of opisthorchiasis, which allows to achieve a higher clinical and parasitological effect while reducing the dose of helminthicidal agents (praziquantel), to reduce the toxic load on the body.

The essence of the proposed method for the treatment of opisthorchiasis is that against a background of predominantly vegetarian nutrition, 2-4 antihomotoxic drugs are used, selected from the group: Hepar compositum, Hepeel, Nux vomica-Homaccord, Chelidonium-Homaccord, Duodenoheel, Leptandra compositum, Momordica compositum, , Ubichinon compositum, Berberis-Homaccord, mainly Hepar compositum, Hepeel, Nux vomica-Homaccord, as well as enterosorbent and eubiotic - all in effective course doses; Praziquantel is used in effective single doses for an effective number of times at intervals that allow influencing various generations of opisthorchis, in a course dose of predominantly not exceeding 2.4 g.

The method includes:

- mainly vegetarian food: cereals, vegetables, fruits, legumes; Easily digestible carbohydrates are excluded. Products of animal origin are excluded completely for the period of treatment or are allowed 1-2 times a week. The drinking regimen, as a component of the proposed nutrition, includes the use of 1.5-2.5 liters of liquid per day (green tea, decoction of dried fruits, decoction of oats, etc., pure water), the intake of liquid is carried out outside the meal (22, 23), not later than 10-20 minutes before eating and / or not earlier than 60-90 minutes after eating;

- administration of antihomotoxic drugs - in recommended daily (or weekly) doses and effective course doses (mainly 5-15 weeks for each drug) evenly throughout the course of treatment or within one to two weeks before and after each dose of praziquantel, or one or two of the drugs within one to two weeks before taking praziquantel, and the other (others) within one to two weeks after taking it. Depending on the nature of the disease, the duration of pathogenetic therapy before and after prescribing praziquantel may vary;

- intake of enterosorbent (for example, bran, lithovite or enterosgel) in the recommended daily dose, mainly for two to three weeks, alternating with breaks of two to three weeks, during the entire course of treatment;

- taking eubiotics (for example, sporobacterin or biovestin-lacto) in the recommended daily dose, mainly for two to three weeks, alternating with breaks of two to three weeks, during the entire course of treatment;

- taking praziquantel in stages in an effective single dose, mainly at a dose of 300-600 mg, an effective number of times, mainly 4-8 times, at intervals of one to four weeks in a course dose, mainly not exceeding 2.4 g.

The duration of the entire course of pathogenetic therapy with the phased use of praziquantel is predominantly 12-15 weeks.

Antihomotoxic drugs are made from natural ingredients: extracts from plants, extracts from animal organs, sterilized cultures of microorganisms, minerals, trace elements, catalysts, etc. The components are processed according to the principles of the homeopathic potentiation technology, i.e. sequential dilution and activation of the action of components by known methods (5, 6, 9).

Etiotropic therapy is considered in the framework of the proposed system as a parallel component of treatment. The authors see the purpose of the helminthicidal agent in its ability to act on the parasite during the period of its activity, thereby allowing for a while to strengthen the position of the body's defense system, the competence of which is the complete sanitation of the body. The principal difference of the praziquantel application scheme proposed within the system is that the drug is prescribed against the background of pathogenetic therapy in small single doses (300-600 mg) repeatedly (in stages) 4-8 times, no more than 2400 mg per course.

An example of one of the recommended drug treatment regimens for 12-15 weeks: 1) Hepar compositum 1 ampoule 1-3 times a week intramuscularly throughout the course of therapy; 2) Nux vomica-Homaccord 10-20 drops 2-4 times a day 30 minutes before meals daily for one to two weeks before and one to two weeks after taking praziquantel; 3) Hepeel 1-2 tablets 2-4 times a day 20 minutes before meals (immediately after Nux vomica-Homaccord) daily for one to two weeks before and one to two weeks after taking praziquantel; 4) blind drainage according to Demyanovich (tubage) - the next morning after each dose of praziquantel; 5) one of the enterosorbents (for example, bran or enterosgel, or Lithuanian): bran for 1-2 teaspoons steamed with boiling water, daily during the course of therapy; enterosgel for 1 tablespoon 2-3 times a day or lithium 1.0 g 2 times a day for two to three week periods of administration, alternating with two to three week intervals during therapy; 6) one of the eubiotics (for example, sporobacterin in a daily dose of 2 ml, biovestin-lacto per day for 8 doses) with two to three-week periods of administration, alternating with two to three-week intervals during therapy; 7) praziquantel in single doses of 300-600 mg repeatedly (step by step) 4-8 times at intervals of 1-4 weeks in a total course dose not exceeding 2.4 g.

As the treatment results show, the proposed pathogenetic therapy provides normalization of the functions of the biliary system (relieving spasms of the sphincters of the biliary system, normalizing its tone, eliminating stasis of bile) and digestion in general, has a detoxifying effect, reduces the sensitizing effect of praziquantel, and ensures timely excretion of toxic parasite decay products.

Examples of treatments with other antihomotoxic drugs.

Example 1. Vegetarian food, 1.5-2.5 liters of fluid per day, the intake of fluid is carried out outside the meal. Litovit is used during the 1st, 2nd, 6th, 7th, 11th, 12th weeks; sporobacterin - during the 3rd, 4th, 8th, 9th, 13th, 14th weeks; praziquantel in a dose of 300 mg at the end of the 3rd, 5th, 7th, 9th, 11th, 13th weeks; Chelidonium-Homaccord - during the 4th, 6th, 8th, 10th, 12th weeks, Leptandra compositum - during the 6th, 7th, 8th, 9th weeks, Hepeel and Ubichmon compositum - during the entire course of therapy.

Example 2. Mostly vegetarian food, the use of meat products - 1-2 times a week; 1.5-2.5 liters of fluid per day, the intake of fluid is carried out outside the meal. Enterosgel is used during the 3rd, 4th, 5th, 8th, 9th, 10th weeks; biovestin-lacto - during the 1st, 2nd, 6th, 7th, 11th, 12th weeks; praziquantel in a dose of 600 mg at the end of the 2nd, 5th, 8th, 11th weeks; Duodenoheel - during the 1st, 2nd, 4th, 5th, 7th, 8th, 10th, 11th; Hepeel and Сoenzyme compositum - evenly throughout the course of therapy.

Information confirming the possibility of carrying out the invention with the implementation of the appointment

To date, the proposed method has treated 16 people, the data for which are given in tables 1 and 2.

In all patients, the diagnosis of chronic opisthorchiasis was confirmed by the detection of opisthorchis eggs in bile or feces. Patients showed manifestations of 3-4 clinical syndromes simultaneously.

The tables show the frequency of detection of clinical syndromes and laboratory signs before treatment and at various times after treatment. The data presented confirm a good clinical and parasitological effect of the treatment. Significant improvement in the well-being and condition of patients, restoration of the functions of impaired organs and systems, in particular, the phenomena of cholangiocholecystitis, biliary dyskinesia of the hypertensive type, pancreatopathy, intestinal dyspepsia, vegetative-vascular dystonia, were noted.

Clinical example No. 1. Patient T., outpatient card No. 23036, a resident of Novosibirsk, applied on February 18, 2002 to the outpatient department of the Moscow City Medical Institute No. 1 with a diagnosis of chronic opisthorchiasis.

Epidemiological data indicate frequent consumption of river fish of the cyprinid family since childhood. The development of the disease began in childhood, when the first skin manifestations (skin itching, papules) appeared, almost weekly. In school years, allergic manifestations intensified - episodes of urticaria occurred every two months on the skin of the face and upper limbs. At the age of ten, antibodies to opisthorchiasis antigen were detected in the blood serum and, on this basis, praziquantel was treated according to the existing standard scheme, after which there were no episodes of urticaria for 5-6 years. After the treatment, I did not eat river fish from the cyprinidae family. From the age of fifteen, allergic manifestations and weekly episodes of skin itching resumed. A year later, drawing pains in almost all joints, heaviness in the epigastric region, a state of fatigue in the evening, the manifestation of vegetovascular dystonia in the form of attacks of shortage of air joined. In the last year, the above conditions resumed, the manifestations of allergic syndrome became more frequent. Over the course of a year and a half, leukopenia was stably recorded, which is considered as one of the most unfavorable factors indicating pronounced endogenous intoxication and the degenerative nature of pathological processes. According to the coprogram, the patient has a pancreatic insufficiency (steatorrhea); in the study of feces, opisthorchis eggs were found; according to ultrasound of internal organs - signs of cholangiocholecystitis.

The patient underwent a course of therapy according to the proposed method: mainly vegetarian food, drinking regimen, including the use of 1.5-2.5 liters of fluid per day. Liquid intake is carried out no later than 10-20 minutes before a meal and / or 60-90 minutes after a meal. Admission Hepar compositum 2 times a week intramuscularly weekly the entire course of therapy for 16 weeks; Nux vomica-Homaccord - 10 drops 2 times a day 30 minutes before meals daily for the 2nd, 3rd, 5th, 6th, 8th, 9th, 11th, 12th th, 14th, 15th weeks of therapy; Hepeel - 1 tablet 3 times a day 20 minutes before meals (immediately after Nux vomica-Homaccord) daily for the 1st, 2nd, 4th, 5th, 7th, 8th, 10th 11th, 13th, 14th weeks of therapy; praziquantel - at a dose of 400 mg repeatedly (in stages) at the end of the 2nd, 5th, 8th, 11th, 14th week of therapy, with blind drainage according to Demyanovich (tubage) the next morning after each dose of praziquantel ; bran - 1-3 teaspoon daily in the morning before breakfast during the entire course of therapy; sporobacterin - daily at 2 ml per day for the 6th, 7th, 10th, 11th, 14th, 15th weeks of therapy.

During therapy, the severity in the epigastrium gradually disappeared, arthralgia decreased significantly in a month and a half, there was practically no weakness, fatigue. Itchy skin, vegetovascular dystonia phenomena ceased to disturb. In the third month of therapy, all complaints of concern to the patient were stopped: arthralgia, skin itching, urticaria, epigastric severity, vegetative-vascular dystonia. At the end of therapy, manifestations of pancreatopathy were stopped (coprogram data); eggs of opisthorchis are not found in feces and bile; there are no manifestations of cholangitis. Leukopenia and lymphocytosis (general blood count), as well as minimal manifestations of cholecystitis (ultrasound) are preserved.

Three months after completion of therapy, positive clinical dynamics persist. According to a general blood test, leukopenia persists, the percentage of lymphocytes in the white blood cell count returns to normal. The result of the study of feces, bile on the eggs of opisthorchis is negative.

After six months, the patient's condition is good, clinically healthy.

After 9 months from the start of treatment, the leukocyte level is restored (complete blood count). The results of the study of feces, bile on the eggs of opisthorchis are negative.

Clinical example No. 2. Patient K., 42 years old (outpatient card No. 28673, a resident of Novosibirsk), applied to the outpatient department of the Moscow Medical and Biological Institute No. 1 with a diagnosis of chronic opisthorchiasis on January 20, 2002. Epidemiological data indicate the constant use of river fish of the cyprinid family since childhood. The development of the disease began at school age (10 years), when a single episode of a rash first appeared. At the age of 17-18, Quincke's edema appeared and almost daily skin itch joined. At the same time, dyspeptic symptoms (nausea, heaviness in the right hypochondrium, gruel-like stools) were disturbing and, almost weekly, there were phenomena of autonomic dystonia in the form of sweating, attacks of lightheadedness. In 1991, it was treated with praziquantel according to the well-known standard method, after which the use of river fish excludes.

Gradually, after 1.5-2 years after praziquantel therapy, the patient noted the appearance of epigastric pain, weakness, and sweating. These symptoms gradually increased from 1993 to 2002. In 2001-2002, the patient noted a significant deterioration in health - severe weakness, sweating, constant epigastric pain, exacerbation of chronic pancreatitis (in the form of mushy stools, attacks of lightheadedness, severe weakness) over the past year 5 times there was a spotty rash on the body, skin itching in the face, thighs, shoulders.

When examining a general blood test, eosinophilia up to 12% was found, in the coprogram - signs of pancreatic function insufficiency (steatorrhea), in the study of feces, opisthorchis eggs were found.

The patient underwent a course of therapy according to the proposed method: vegetarian food, drinking regimen, including the use of 1.5-2.5 liters of fluid per day. Liquid intake is carried out no later than 10-20 minutes before a meal and / or 60-90 minutes after a meal. Taking Hepar compositum once a week intramuscularly weekly the entire course of therapy for 15 weeks; Nux vomica-Homaccord - 10 drops 3 times a day 30 minutes before meals daily on the 1st, 2nd, 3rd, 5th, 6th, 8th, 9th, 11th , 12 weeks of therapy; Hepeel - 1 tablet 4 times a day 20 minutes before meals (immediately after Nux vomica-Homaccord) daily on the 2nd, 3rd, 4th, 6th, 7th, 9th, 10- th, 12th, 13th weeks of therapy; praziquantel in a dose of 600 mg at the beginning of the 3rd, 6th, 9th, 12th weeks of therapy with blind drainage according to Demjanovich (tubage) - the next morning after each dose of praziquantel; Lithuanian M for 1-2 tablespoon in the morning or in the morning and in the evening every day on the 2nd, 3rd, 4th, 7th, 8th, 9th, 12th, 13th, 14th weeks of therapy; biovestin-lacto 8 doses daily during the 3rd, 4th, 8th, 9th, 13th, 14th weeks of therapy.

During therapy, epigastric pain, weakness, and fatigue gradually disappeared. The chair is decorated. Significantly decreased skin itching, rashes are much less common and less pronounced. The phenomena of vegetovascular dystonia persisted. In the third month of therapy, all complaints of concern to the patient were stopped: skin itching, epigastric pain, manifestations of vegetovascular dystonia, signs of chronic pancreatitis. The content of blood eosinophils was normalized (2%), the manifestations of pancreatopathy (coprogram) were stopped, the result of the study of feces on the eggs of the opisthorchis is negative.

Three, six months after completion of therapy, the condition is good, clinically healthy. The results of the study of feces, bile on the eggs of opisthorchis are negative.

Information confirming receipt of a technical result

The proposed method has the following advantages compared to the prototype:

- a significant increase in the clinical effect of therapy: restoration of the functions of impaired organs and systems: liver, biliary tract, intestines, pancreas; reduction of allergic manifestations; stopping vegetovascular reactions (sweating, lability of the pulse, palpitations, attacks of lightheadedness). As can be seen from tables 1 and 2, after treatment, the frequency of detection of the following disorders in the activity of these organs and systems in patients is significantly reduced: (comparison of data before treatment and six months after treatment): cholangiocholecystitis - from 75 to 12.5%, allergic syndrome - from 37.5 to 12.5%, asthenic syndrome - from 81.25 to 18.75%, autonomic dystonia - from 75 to 18.75%, pancreatopathy - from 37.5 to 6.25%, arthralgia - from 37.5 to 6.25%, DZHVP - from 75 to 6.25%, intestinal dyspepsia - from 62.5 to 12.5%, subfebrile condition - from 18.75 to 0%. As for the prototype, the literature reflects mainly the restoration of the functions of the biliary system;

- a decrease in the total toxic load on the body, a reduction in the dose of praziquantel per course of treatment. More rare cases of side effects. Adverse reactions when using praziquantel according to the prototype in a dose of 25 mg / kg to 75 mg / kg were observed in 66.7% and 89.7% of treated patients, respectively (16, 17). Adverse reactions are manifested in the form of dizziness, feelings of intoxication, headache, drowsiness, dyspeptic disorders (nausea, vomiting, abdominal pain, diarrhea with an admixture of blood, etc.), excessive sweating, allergic reactions (skin rashes, itching). In the treatment according to the proposed method, an adverse reaction manifested itself only in the form of dizziness and only in one patient out of 16 (6, 25%). In connection with a lower toxic load on the body, it becomes possible to treat opisthorchiasis in patients for whom the standard regimen is unacceptable due to severe liver pathology;

- increase the parasitological effectiveness of the treatment of opisthorchiasis. When using comparable course doses of praziquantel according to the prototype (25-40 mg / kg) and according to the invention, the absence of parasite eggs in bile and feces is observed: after three months, in 62-80% of patients treated according to the prototype and in 93.75% of patients, treated by the proposed method; after six months, in 45.5% (dose 25 mg / kg) and 68.2% (dose 40 mg / kg) of patients treated according to the prototype (18) and in 87.5% of patients treated with the proposed method.

Bibliography.

1. Ozeretskovskaya N.N. Approaches of the national school of parasitologists-immunologists to the treatment of parasitic diseases / Honey. parasitology and parasitar. diseases, 1998, No. 2.

2. Recommendations of the Department of Infectious Diseases of the NGMI for students.

3. Finger A. Digestive system disease in chronic opisthorchiasis. Novosibirsk 1996 year

4. Lepekhin A.V., Buzhak N.S. The influence of various factors on the immune status of patients with chronic opisthorchiasis. /Honey. parasitology and parasitar. Diseases, 1988, No. 2, pp. 18-20.

5. “Register of medicines of Russia”, 2000, 7th ed.

6. Vidal Handbook, 1998

7. Bronstein A.M. The ratio of clinical and parasitological efficacy in the treatment of opisthorchiasis with chloroxyl. /Honey. parasitology and parasitar. diseases, 1982, No. 5.

8. Bronstein A.M. Praziquantel and other modern drugs and chemotherapy methods for human liver trematodoses (opisthorchiasis, clonorchiasis) (literature review). /Honey. parasitology and parasitar. Diseases, 1984, No. 6, pp. 51-56.

9. General therapy. Complex homeopathic preparations of the company “Biologische Heilmittel Heel GmbH”. Handbook 2001-2002.

10. Belov G.F., Krasnova E.I., Kuznetsova V.G. Recurrent forms of opisthorchiasis. / Honey. parasitology and parasitar. Diseases, 1994, No. 2, pp. 19-21.

11. Schulz R.S., Gvozdev E.V. Fundamentals of general helminthology. - M., 1976, v. 3, p. 17-67.

12. Meat-eaters B.C. Epidemiology of opisthorchiasis. Tomsk 1960 year

13. Plotnikov N.N. Opisthorchiasis. Moscow. 1953

14. Proceedings of the All-Siberian Conference of Physicians. - Novosibirsk, 1959, p. 391-522.

15. Kassirsky I.A., Milevskaya Yu.L. Essays on modern clinical therapy. - Tashkent, 1970

16. Bronstein A.M.,. Ozeretskovskaya N.N., Panteleeva E.Ya. et al. Analysis of four treatment regimens of praziquantel for individuals invaded by opisthorchis felineus under conditions excluding reinfestation. /Honey. parasitology and parasitar. Diseases, 1988, No. 5, pp. 19-23.

17. Bronstein A.M., Merzlova N.B., Veretennikova N.A. Treatment with praziquantel on an outpatient basis in patients in the outbreak of opisthorchiasis of the Komi-Permyak Autonomous Okrug. /Honey. parasitology and parasitar. Diseases, 1989, No. 2, pp. 30-33.

18. Bronstein A.M., Nikiforova T.F., Yarotsky L.S. The first experience with praziquantel in the outpatient setting of the focus of opisthorchiasis in the Ukrainian SSR. / Honey. parasitology and parasitic diseases, 1988, No. 1, pp. 59-62.

19. Gibson T.E. Helmintol. 1953. Vol. 27, No. 1, pp. 29-40.

20. Bayandina D.G., Bychkov V.V., Ginkover A.G., Kazantseva G.N. Pathomorphological changes in the liver and lymphoid organs of golden hamsters infected with opisthorchis during treatment with praziquantel. /Honey. parasitology and parasitic diseases, 1987, No. 5, p. 37-41.

21. Lanninger Bolling, Dagmar. The healing power of blood: a guide to autohemotherapy. Per. with him. - M .: Arnebia. 2001 .-- 140 p.

22. Handbook of dietetics. Ed. Tutelyana V.A., Sansonova M.A. - M .: Medicine, 2002

23. Sushchansky A.G., Liflyansky V.G. Encyclopedia of healthy nutrition. T.1, 2. - St. Petersburg: “Neva”, 1999

Claims (7)

1. A method of treating opisthorchiasis, including the use of pathogenetic agents and praziquantel, characterized in that, against a background of predominantly vegetarian nutrition, 2-4 antihomotoxic agents selected from the group of Hepar compositum, Hepeel, Nux vomica-Homaccord, Chelidonium-Homaccosit, Duodenoheel, Leptandra , Momordica compositum, Coenzyme compositum, Ubichinon compositum, Berberis-Homaccord, as well as enterosorbent and eubiotic in effective course doses; praziquantel is used an effective number of times at intervals that allow influencing various generations of opisthorchis, in a course dose of mainly not exceeding 2.4 g. 2. The method according to claim 1, characterized in that antihomotoxic drugs are used evenly during the course of treatment, or within one to two weeks before and after each dose of praziquantel, or one or two of the drugs is used within one to two weeks before administration praziquantel, and the other (others) - within one to two weeks after taking it. 3. The method according to claim 1, characterized in that the enterosorbent is used predominantly in two to three week periods with interruptions of two to three weeks during the entire course of treatment. 4. The method according to any one of claims 1 to 3, characterized in that they use an enterosorbent selected from the group of bran, lithovite, enterosgel. 5. The method according to claim 1, characterized in that the eubiotic is used predominantly in two to three week periods with interruptions of two to three weeks during the entire course of treatment. 6. The method according to any one of claims 1 and 5, characterized in that sporobacterin or biovestin-lacto is used as an eubiotic. 7. The method according to claim 1, characterized in that praziquantel is used mainly 4-8 times at intervals of one to four weeks in a single dose, preferably of 300-600 mg, during the course of treatment, which is mainly 12-15 weeks.