RU2213579C1 - Disinfecting agent - Google Patents

Abstract

FIELD: biocide compositions. SUBSTANCE: disinfecting agent contains acid, detergent, carbamide or its derivative, inhibitor of metal corrosion and sodium perborate taken in the definite ratio. Invention allows preparing highly active and nontoxic disinfecting agent with prolonged storage time. Proposed composition can be used as a disinfecting agent. EFFECT: improved and valuable properties of agent. 5 cl, 1 tbl, 5 ex

Description

 The invention relates to biocidal compositions, more specifically relates to a disinfectant and will find application for the disinfection of rooms, sanitary equipment, patient care items and preferably medical devices for infections of bacterial, viral, fungal etiology and spores in medical institutions.

 For these applications, the need for effective and stable broad-spectrum biocidal compositions has increased. In addition, the biocidal compositions used for the disinfection of medical devices, in addition to efficiency and stability, are required to have low corrosion activity with respect to the metals from which medical instruments are usually made.

 Recently, many liquid disinfectant formulations have been developed that meet these needs. Domestic developments of compositions of the indicated purpose use compounds based on chlorine, hydrogen peroxide, formaldehyde, and phenol as the active substance. Hydrogen peroxide can be distinguished from this group of sufficiently toxic substances as an environmentally friendly substance, which, however, is unstable in the light when interacting with metals, organic substances and alkalis.

 For example, EP-A-0357238 (Steris Corp.) describes a bactericidal composition comprising a strong oxidizing agent, a corrosion inhibitor of copper and brass, a buffering agent, at least one anti-corrosion agent preventing corrosion of aluminum, carbon steel and stainless steel, and a wetting agent . Corrosion inhibitors presented specifically for brass and aluminum contain triazoles and molybdates, which are known to have adverse toxicity and which are therefore undesirable for use in medical facilities.

 Also known is a tool that provides high efficiency of disinfection and sterilization of medical devices for infections of bacterial and fungal etiology (US Pat. RF 2036664, MKI: A 61 L 2/16). The named tool has a high buffer capacity (pH 7.5-9.5) and includes glutaraldehyde, sodium bicarbonate, sodium hydrogen phosphate. The specified tool is used after mixing glutaraldehyde with alkaline ingredients immediately before use until the desired pH is achieved, providing high disinfecting and sterilizing indicators. However, this tool has a relatively low stability due to the fact that the stability of glutaraldehyde drops sharply with increasing pH due to the formation of polymers.

 In addition, the indicated product in its marketable form is a liquid two-component system, and the complexity of its use is associated with the need to prepare it immediately before use.

 Currently, in addition to the above industry requirements, solid forms of disinfectants are needed that are more stable during storage and more suitable for transportation.

 A disinfectant is known in marketable powder form containing a peroxide compound - hydrogen peroxide, N-alkanoylaminopropyl dimethylbenzylammonium chloride, urea and filler - aerosil (RF patent 2083228, MKI: A 61 L 2/16, 1997).

The specified tool exhibits high bactericidal, fungicidal and sporocidal activity, including shows effectiveness against S.aureus, E.coli, P.vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens. However, this tool has a relatively short shelf life, namely, the shelf life of the specified powdered funds is 18 months; the shelf life of this product in working liquid form is not more than 12 months, after which the liquid exfoliates and the product loses its activity. In addition, the specified tool in marketable powder form can be obtained by performing a multi-stage process.

 A powder disinfectant is known containing sodium perborate (0.5-25.0 wt.%), Alkali metal iodide (0.5-15.0 wt.%), As well as 0.5-30.0 as an active ingredient. wt.% polyvinylpyrrolidone and up to 98.5 wt. % organic or inorganic acid, selected, for example, among sulfamic acid, citric acid, as an activator, which also provides the pH of the indicated product during its use in the form of an aqueous solution (GB 2084875 A, MKI: A 01 N 59/12, 1982).

 The specified disinfectant is a powdery product, which ensures the stability of its properties during temperature fluctuations during storage, transportation. In addition, the named tool allows you to achieve reliable sanitation results due to the high content of a highly effective active substance - sodium perborate and alkali metal iodide, however, the named tool is highly toxic and corrosive due to its high content of acid ingredient and therefore is not universal and suitable for processing products made of metal.

 As a prototype, a detergent-disinfectant for treating a metal surface was selected containing oleic acid (7-9 wt.%) And triethanolamine (3-5 wt.%), Which form a triethanolamine oleic acid soap, which is a highly effective surfactant that promotes degreasing of the processed metal surface. Said detergent-disinfectant also contains oxyphos (5-7 wt.%), Used as a surfactant, providing the degreasing ability of the specified funds and protection against corrosion of treated metal surfaces; ethyl cellosolve (14-16 wt.%), providing the dissolution of fatty contaminants of the treated metal surface; flotation reagent-oxal (9-11 wt.%); carbamide (14-16 wt.%); polyhexamethylene guanidine hydrochloride (0.5-1.5 wt.%), providing disinfecting properties of the named funds, and water - the rest is up to 100 wt. % (RF patent 2084498, MKI: C 11 D 3/43, 1997).

 The specified detergent-disinfectant has a high degreasing ability and provides a disinfecting effect while maintaining anticorrosive ability, however, the indicated product in its present form is a liquid system and does not have a wide spectrum of antimicrobial action.

 The basis of the claimed invention is the task, through the use of products manufactured by domestic industry, to create, on the basis of a highly effective active substance - sodium perborate, an effective and stable disinfectant with a wide spectrum of action, having a high bactericidal, fungicidal, disinfecting activity, having a powdery form convenient for storage and transportation, which would dissolve well in water and would be suitable for processing medical devices.

This problem is solved when creating a disinfectant, including acid, urea or its derivative, detergent and a metal corrosion inhibitor, which according to the invention additionally contains sodium perborate and sodium bicarbonate and / or a mixture of polyoxyethylene glycol ethers of primary alcohols of fraction C ₁₆ -C ₂₀ , while named ingredients it contains in the following ratio, wt.%:
Acid - 5 - 10
Detergent - 4 - 15
Urea or its derivative - 30 - 50
Metal Corrosion Inhibitor - 1 - 2
Sodium bicarbonate and / or a mixture of polyoxyethylene glycol ethers of primary alcohols fraction C ₁₆ -C ₂₀ - 1 - 4
Sodium Perborate - Else
Thanks to the invention, an effective and stable disinfectant with a wide spectrum of activity, a high bactericidal, fungicidal, disinfecting activity, a powdery form that is easy to store and transport, which is highly soluble in water and provides high disinfection efficiency, is created on the basis of products manufactured by the domestic industry. sterilization of products, including medical supplies, for bacterial infections, including tuberculosis, and fungal infections, including Diozu and tinea, etiology.

According to the invention, in order to ensure reliable quality of disinfection by removing contaminants on the treated surface, it is advisable that the disinfectant as a detergent contain a product based on potassium, sodium, ammonium or triethanolammonium salts of higher fatty (C ₈ -C ₁₈ ) acids, naphthenic acids or resin acids.

 It is useful according to the invention that the detergent contains a substance selected from the group consisting of sodium lauryl sulfonate, sodium laurate, sodium palmitate, potassium palmitate, sodium stearate, potassium stearate, sodium oleate, potassium oleate.

 According to the invention, it is advisable that the disinfectant as an acid contain a substance selected from the group consisting of sulfuric acid, phosphoric acid, oxalic acid, citric acid, acetylsalicylic acid, barbituric acid, urea, alcohol, which allows activation of sodium perborate and regulation of the pH of the aqueous medium disinfectant solution.

 To be able to use the inventive tool for processing products made of metal, according to the invention, it is advisable that the disinfectant as a metal corrosion inhibitor contain a substance selected from the group consisting of amine, nitrogen-containing heterocyclic compound, mercaptan, urea, thiocarbamide, sulfide, aldehyde, chromate , phosphate, acridine, acriflavine, sulfonated oil residue, sulfonated castor oil, diethylamine, tetra-substituted ammonium base.

 Further objectives and advantages of the claimed invention will become apparent from the following detailed description of the disinfectant and specific examples of its composition.

 The disinfectant of the present invention contains sodium perborate as an active ingredient, preferably in an amount of 40 to 60% by weight.

Sodium perborate (peroxoborate) - Na ₂ • B ₂ (O ₂ ) ₂ (OH) ₄ • 6H ₂ O belongs to the class of peroxide compounds, is produced by the domestic industry and is a crystalline substance, stable during storage and able to dissolve well in water.

 To increase the resistance of the active substance of the claimed disinfectant, it contains acid in an amount of from 5 to 10 wt.%. In addition, the acid in the inventive disinfectant regulates the pH of the aqueous solution of this disinfectant.

 As an acid, the disinfectant contains a substance mainly selected from the group comprising sulfuric acid, phosphoric acid, oxalic acid, citric acid, acetylsalicylic acid, barbituric acid, urea, alcohol.

 According to the invention, the inventive disinfectant contains from 30 to 50 wt.% Urea or its derivative, for example thiocarbamide.

The inventive disinfectant also contains a detergent mainly based on potassium, sodium, ammonium or triethanolammonium salts of higher fatty (C ₈ -C ₁₈ ) acids, naphthenic acids or resin acids in an amount of from 4 to 15 wt.%; said detergent provides both a washing and disinfecting effect.

 Advantageously, a soap powder may be contained as a detergent, including any solid or anionic or cationic substance, including sodium lauryl sulfate, sodium laurate, sodium palmitate, potassium palmitate, sodium stearate, potassium stearate, sodium oleate, potassium oleate.

 The disinfectant proposed in the present invention also contains an inhibitor, that is, a substance inhibiting chemical processes, namely, reducing the rate of destruction of various metallic materials. The inhibitor content is from 1 to 2 wt.%.

 As an inhibitor, the claimed disinfectant may contain a substance mainly selected from the group consisting of amine, nitrogen-containing heterocyclic compound, mercaptan, urea, thiocarbamide, sulfide, aldehyde, chromate, phosphate, acridine, acriflavine, sulfonated oil residue, sulfonated castor oil, diethylamine , tetra-substituted ammonium base.

In addition to the named ingredients, the claimed disinfectant contains sodium bicarbonate mainly in an amount of at least 1 wt.% And / or a mixture of polyoxyethylene glycol ethers of primary alcohols of the C ₁₆ -C ₂₀ fraction obtained by organoaluminum synthesis in an amount of from 1 to 4 wt. %, which, in particular, provide the aggregative stability of the claimed product, reduce the rate of aging in the aquatic environment.

A mixture of polyoxyethylene glycol ethers of primary alcohols of the C ₁₆ -C ₂₀ fraction obtained by organoaluminum synthesis is produced by the domestic industry under the trade name Oksanol TsS-100 (TU 6-36-1029-90).

 The claimed product may also contain inorganic electrolytes, high molecular weight compounds such as saponin, gelatins, proteins (protective colloids), complexing agents (complex salts of heavy metals or heterocyclic compounds, for example derivatives of pyridine, imidazole, thiazole, solid emulsifiers, for example oxides, carbonates, sulfates, kaolins, which contribute to the stabilization of the claimed disinfectant.

 The disinfectant proposed in the present invention may also contain an aromatic substance (0.1-0.5 wt.%) And a dye (0.01-0.5 wt.%).

 As the aromatic substance suitable in the framework of the present invention, any ether used in food and cosmetic products can be mentioned.

 As a colorant suitable in the framework of the present invention, water-soluble colorants such as methylene blue, brilliant green, acridine dye can be mentioned.

 The disinfectant proposed in the present invention, has the form of a powder, is readily soluble in water, which makes it easy to obtain an aqueous working solution having a pH of 5-8, the desired and required concentration of the active substance.

 The disinfectant of the present invention is particularly suitable for use as a medical biocidal agent. Preferably, the inventive disinfectant is used to disinfect medical equipment having metal parts, for example, aluminum, copper and especially steel, to be disinfected, including dental and surgical instruments. For example, the inventive tool is particularly suitable for the disinfection of rigid and flexible endoscopes and instruments for them. The disinfectant ingredients selected according to the invention interact with one another to protect metal parts, in particular steel parts, from local, in particular pitig corrosion, while achieving the same protection, if not better, than that provided by toxic molybdate, triazole and / or wetting agent.

 The disinfectant proposed in the present invention is a composition that is simple in composition, effective and stable for a long shelf life, has good detergent properties. The inventive disinfectant due to the indicated ratio of these ingredients has a high bactericidal, fungicidal, disinfecting activity, including effective on gram-positive and gram-negative bacteria (including tuberculosis microbacteria), fungi of the genus Candida and Trichophyton, viruses (pathogens of parenteral viral hepatitis, herpes simplex virus, herpes enterovirus infections, hepatitis A, polio, influenza and other acute respiratory viral infections), spores, green grown.

 The disinfectant proposed in the present invention does not have a destructive effect on the processing objects. In addition, the disinfectant proposed in the present invention must be stored for up to three years without losing its activity and physical properties.

Example 1
A dry disinfectant mixture is obtained by mixing, containing 39 wt.% Sodium perborate, 5 wt.% Citric acid, 4 wt.% Sodium lauryl sulfate, 50 wt.% Urea, 1 wt.% Mercaptan, 1 wt.% Sodium bicarbonate.

 When determining micromicrobial activity and when disinfecting medical instruments, an aqueous solution of the required concentration of the obtained disinfectant is used.

Assessment of the disinfectant activity of the agent was determined in accordance with the Instruction for the determination of the bactericidal properties of new disinfectants 739-68 from 05/06/68. Bactericidal, fungicidal and saporocidal activity was determined by the method of cambric test objects against S.aureus, E. coli, P. vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens.

 The residual contamination of the surfaces of the processed tools was determined after keeping them in a 2% aqueous solution (using a disinfectant) at room temperature for 5 and 30 minutes. The research data are presented in the table.

 When storing the obtained disinfectant in powder form and in the form of an aqueous solution for 3 years, no changes in its physical state and changes in the content of the active substance (in terms of the content of active hydrogen peroxide) are noted. Thus, the activity of the obtained disinfectant is maintained with a long shelf life.

Example 2
A dry mixture of a disinfectant containing 49 wt.% Sodium perborate, 8 wt.% Phosphoric acid, 10 wt.% Potassium alkylaryl sulfonate, 30 wt.% Thiocarbamide, 2 wt.% Diethylamine, 1 wt.% Mixture of primary polyoxyethylene glycol ethers is obtained by mixing alcohols of the fraction C ₁₆ -C ₂₀ (Oxanol TsS-100).

 When determining micromicrobial activity and when disinfecting medical instruments, an aqueous solution of the required concentration of the obtained disinfectant is used.

Assessment of the disinfectant activity of the agent was determined in accordance with the Instruction for the determination of the bactericidal properties of new disinfectants 739-68 from 05/06/68. Bactericidal, fungicidal and saporocidal activity was determined by the method of cambric test objects against S.aureus, E. coli, P. vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens.

 The residual contamination of the surfaces of the processed tools was determined after keeping them in a 1.5% aqueous solution (using a disinfectant) at room temperature for 5 and 30 minutes. The research data are presented in the table.

 When storing the obtained disinfectant in powder form and in the form of an aqueous solution for 3 years, no changes in its physical state and changes in the content of the active substance (in terms of the content of active hydrogen peroxide) are noted. Thus, the activity of the obtained disinfectant is maintained with a long shelf life.

Example 3
Receive by mixing a dry disinfectant mixture containing 36 wt.% Sodium perborate, 5 wt.% Citric acid, 4 wt.% Sodium palmitate, 50 wt.% Urea, 1 wt.% Mercaptan, 2 wt.% Sodium bicarbonate and 2 wt. % mixture of polyoxyethylene glycol ethers of primary alcohols of fraction C ₁₆ -C ₂₀ (Oxanol TsS-100).

 When determining micromicrobial activity and when disinfecting medical instruments, an aqueous solution of the required concentration of the obtained disinfectant is used.

Assessment of the disinfectant activity of the agent was determined in accordance with the Instruction for the determination of the bactericidal properties of new disinfectants 739-68 from 05/06/68. Bactericidal, fungicidal and saporocidal activity was determined by the method of cambric test objects against S.aureus, E. coli, P. vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens.

 The residual contamination of the surfaces of the treated medical instruments was determined after keeping them in a 1% aqueous solution using a disinfectant at room temperature for 5 and 30 minutes. The research data are presented in the table.

 When storing the obtained disinfectant in powder form and in the form of an aqueous solution for 3 years, no changes in its physical state and changes in the content of the active substance (in terms of the content of active hydrogen peroxide) are noted. Thus, the activity of the obtained disinfectant is maintained with a long shelf life.

Example 4
Get by mixing a dry mixture of a disinfectant containing 49 wt. % sodium perborate, 1 wt.% oxalic acid, 15 wt.% potassium stearate, 30 wt.% carbamide, 1 wt.% sulfonated castor oil, 4 wt.% a mixture of polyoxyethylene glycol ethers of primary alcohols of fraction C ₁₆ -C ₂₀ (Oxanol TS -100).

 When determining micromicrobial activity and when disinfecting medical instruments, an aqueous solution of the required concentration of the obtained disinfectant is used.

Assessment of the disinfectant activity of the agent was determined in accordance with the Instruction for the determination of the bactericidal properties of new disinfectants 739-68 from 05/06/68. Bactericidal, fungicidal and saporocidal activity was determined by the method of cambric test objects against S.aureus, E. coli, P. vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens.

 The residual contamination of the surfaces of the treated medical instruments was determined after keeping them in a 1.5% aqueous solution (using a disinfectant) at room temperature for 5 and 30 minutes. The research data are presented in the table.

 When storing the obtained disinfectant in powder form and in the form of an aqueous solution for 3 years, no changes in its physical state and changes in the content of the active substance (in terms of the content of active hydrogen peroxide) are noted. Thus, the activity of the obtained disinfectant is maintained with a long shelf life.

Example 5
Obtained by mixing a dry mixture of a disinfectant containing 37 wt. % sodium perborate, 5 wt.% acetylsalicylic acid, 4 wt.% sodium oleate, 50 wt.% urea, 4 wt.% sodium bicarbonate.

 When determining micromicrobial activity and when disinfecting medical instruments, an aqueous solution of the required concentration of the obtained disinfectant is used.

Assessment of the disinfectant activity of the agent was determined in accordance with the Instruction for the determination of the bactericidal properties of new disinfectants 739-68 from 05/06/68. Bactericidal, fungicidal and saporocidal activity was determined by the method of cambric test objects against S.aureus, E. coli, P. vulgaris, P.aeruginosa, Mycobacteruim P ₅ , T.gypsennt, B.carens.

 The residual contamination of the surfaces of the processed tools was determined after keeping them in a 2% aqueous solution (using a disinfectant) at room temperature for 5 and 30 minutes. The research data are presented in the table.

 When storing the obtained disinfectant in powder form and in the form of an aqueous solution for 3 years, no changes in its physical state and changes in the content of the active substance (in terms of the content of active hydrogen peroxide) are noted. Thus, the activity of the obtained disinfectant is maintained with a long shelf life.

Claims (4)

1. A disinfectant, including acid, urea or a derivative thereof, a detergent and a metal corrosion inhibitor, characterized in that it further comprises sodium perborate and sodium carbonate and / or a mixture of polyoxyethylene glycol ethers of primary alcohols of fraction C ₁₆ -C ₂₀ in the following ratio, wt .%:
Acid - 5-10
Detergent - 4-15
Urea or its derivative - 30-50
Metal Corrosion Inhibitor - 1-2
Sodium carbonate and / or a mixture of polyoxyethylene glycol ethers of alcohols fraction C ₁₆ -C ₂₀ - 1-4
Sodium Perborate - Else
2. The tool according to claim 1, characterized in that as a detergent, it contains a product based on potassium, sodium, ammonium or triethanolammonium salts of higher fatty (C ₈ -C ₁₈ ) acids, naphthenic acids or resin acids.  3. The tool according to claim 1, characterized in that the detergent contains a substance selected from the group comprising sodium lauryl sulfonate, sodium laurate, sodium palmitate, potassium palmitate, sodium stearate, potassium stearate, sodium oleate, potassium oleate.  4. The tool according to claim 1, characterized in that as the acid it contains a substance selected from the group comprising sulfuric acid, phosphoric acid, oxalic acid, citric acid, acetylsalicylic acid, barbituric acid, carbamide, alcohol.  5. The tool according to claim 1, characterized in that, as a metal corrosion inhibitor, it contains a substance selected from the group consisting of amine, nitrogen-containing heterocyclic compound, mercaptan, carbamide, thiocarbamide, sulfide, aldehyde, chromate, phosphate, acridine, acriflavine, sulfonated oil residue, sulfonated castor oil, diethylamine, tetra-substituted ammonium base.

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