RU2287320C2 - Anti-dandruff shampoo - Google Patents

Abstract

FIELD: perfumery-cosmetic industry.

SUBSTANCE: the suggested anti-dandruff contains oxyethylated ether of aliphatic alcohol (n=2-5)or oxyethylated ether of aliphatic alcohol (n=8-20), diethanolamide of carbonic acid of coconut fraction, cocoamidopropyl betaine, polyethylene glycol PEG (40-400), the compound of polyguanidine, hydrooxyacid, sodium, hydroxyacid, sodium salt of lactic acid, perfumery composition and water. The suggested shampoo is of high bactericidal action, water. Shampoo is of higher bactericidal action, increased stability at keeping and reveals high fungicidal activity.

EFFECT: higher efficiency.

2 cl, 3 ex, 4 tbl

Description

The invention relates to the perfumery and cosmetics industry, and in particular to products intended for washing hair containing substances that improve the condition of hair and scalp.

Known means for washing hair with increased biological activity, bactericidal, tonic cosmetic effect. The composition of the shampoo includes components in the following ratio, wt.%: Sulfa ethoxylates 39-41, blowing agent 6.2-7.0, monoethanolamide 3.6-4.2, glycerol 2.0-5.0, honey bee 3.7 -8.0, alcohol tincture of propolis 10% 0.1, bee venom 0.00004, sodium chloride 2.0-6.0, formalin 0.2, dye 0-0.01, perfume 2.0 and water the rest (Pat. RF No. 2021806, class A 61 K 7/50, 1995).

However, formalin, which is part of the well-known shampoo, is a very toxic carcinogen.

The closest technical solution to the proposed is an improved anti-dandruff shampoo containing ketoconazole or elubiol, one or more surfactants, a foaming agent, a thickener sufficient for the final composition to have a certain viscosity of 4000-9000 cP, a preservative, bottled hydroxytoluene or bottled hydroxyanosole, also an acid, base or buffer, so that the pH is about 4. The shampoo has a good foaming ability, and also condition the hair and chiv degradability (Pat. Russian №2154464, cl. A 61 K 7/06, BI №23, 2000).

However, the known shampoo has several disadvantages. Ketoconazole and elubiol, which are part of the shampoo as bactericidal agents, have a narrow spectrum of bactericidal action and are mainly used as antifungal compounds. In addition, they have insufficient stability and are not widely available.

The technical problem solved by this invention is to increase the bactericidal action of shampoo, increase storage stability and improve therapeutic effect.

To solve the technical problem in an anti-dandruff shampoo, which includes a disinfectant, cocoamidopropyl betaine, perfume composition and water, a polyguanidine compound is used as a disinfectant and an ethoxylated ester of aliphatic alcohol (n = 2-5) or ethoxylated ester of aliphatic alcohol are added -20), coconut fraction carboxylic acid diethanolamide, PEG polyethylene glycol (40-400), α-hydroxy acid and lactic acid sodium salt in the following ratio, wt.%:

hydroxyethylated aliphatic alcohol ester (n = 2-5) or ethoxylated ester of aliphatic alcohol (n = 8-20) 4.0-16.0 coconut fraction diethanolamide carboxylic acid 0.5-10.0 cocoamidopropyl betaine 0.5-10.0 polyethylene glycol PEG (40-400) 2.0-6.0 polyguanidine compound 0.1-1.0 α-hydroxy acid 0.2-2.0 lactic acid sodium salt 0.5-1.0 perfume composition 0.1-0.5 water rest

In the anti-dandruff shampoo, poly- (4,9-dioxadodecanguanidine) phosphate, or poly- (4,9-dioxadodecanguanidine) chloride, or polyhexamethylene guanidine citrate / formate is used as the polyguanidine compound.

In anti-dandruff shampoo, lactic acid, or glycolic acid, or citric acid, or malic acid is used as the α-hydroxy acid.

The invention is illustrated as follows.

The surfactants used in the proposed shampoo composition are nonionic surfactants. The use of nonionic surfactants improves the consistency, rheological characteristics of the shampoo, gives the hair softness and silkiness. Nonionic surfactants cause a less pronounced denaturing effect compared to anionic surfactants.

The oxyethylated ester of aliphatic alcohol (n = 2-5) used in the composition of the shampoo as a surfactant is distinguished by the fraction of alcohol (lauric, myristic, palmitic) in the molecule and the degree of hydroxyethylation (from 2 to 5). The ethoxylated ester of aliphatic alcohol (n = 2-5) provides mild detergent properties, high solubility of shampoo ingredients, and the creation of optimally balanced formulations. Apply ethoxylated ester of aliphatic alcohol of lauric fraction: Laureth-2 (Oxanol L-2), Laureth-3, Laureth-5, myristic fraction: Mireth-2, Mireth-4, palmitic fraction: Cetareth-2, Cetareth-5, - products Cao Chemical, Japan; Akipo; Clariant; Genapol; Cognis; Arlipon, Texapon.

The oxyethylated ester of aliphatic alcohol used in the proposed shampoo composition as a surfactant (n = 8-20) is distinguished by the fraction of alcohol (stearic, oleic, lauric and palmitic) in the molecule and the degree of hydroxyethylation (from 8 to 20). The ethoxylated ester of aliphatic alcohol (n = 8-20) is a liquid or pasty substance that is readily soluble in water, ethanol, benzene, provides mild detergent properties, compatibility of ingredients, and prevents the separation of shampoo. Use the ethoxylated ether of the aliphatic alcohol of the lauric fraction: Laureth-8, Laureth-12, Laureth-18 (Oxanol-18), the palmitic fraction: Cetareth-12, Cetareth-18 - products of Cao Chemical, Japan, Akipo trademark, Clariant trademark Cognis Genapol, a trademark of Arlipon, Texapon, as well as ethoxylated sorbitan ether (twins) with an oxyethylation degree of n = 20: tween 20 — monooleate, tween 40 (TL-N) —monopalmitate, tween 60 monostearate — products of Cao Chemical, Japan .

The coconut fraction diethanolamide of the coconut fraction used in the proposed shampoo composition as a surfactant is a yellow liquid substance, readily soluble in water, isopropyl alcohol, xylene. The use of the coconut fraction diethanolamide of the coconut fraction as a nonionic surfactant makes it possible to obtain dermatologically soft shampoos with stable foam. Production of the Eur-O-Compound company trademark: Eur-Amid; - Cognis company trademark Comperlan; KAO EUROPE company trademark Aminol KDE.

Cocoamidopropyl betaine is a yellowish clear liquid; pH = 5.2 (10% solution in deionized water). Cocoamidopropyl betaine is used as a mild, nonionic surfactant, a conditioning component, and an additive that enhances the safety of the formulation. The manufacturer is Eur-O-Compound, Euraguat C 47, Dehyton PK 45, Cao Chemical, Japan, Betadet, Clariant, Genagen.

Used as a thickener in the proposed composition of the shampoo polyethylene glycol PEG 40, or PEG 75, or PEG 180, or PEG 400 is a nonionic oxygen-containing high molecular weight compound that provides the necessary rheological properties (to create a viscosity in the range from 2000 to 10000 cPs (at room temperature) improves skin hydration and hair styling, improves hair elasticity PEG 40 - made by BASF, PEG 75 - made by BASF, PEG 180 - made by Dow Chemical, PEG 240 - made by Toho, PEG 400 TU 2483-167-05757587-2000.

The appearance of dandruff is associated to one degree or another with seborrhea and the activity of the microscopic fungus Pityrosporum ovale (P.ovale) or, according to another classification, Malassezia furfur.

The composition of the proposed anti-dandruff shampoo is active against gram-positive and gram-negative pathogenic microorganisms, and also shows high activity against pathogenic dermatophytes affecting the skin of the person: Pityrosporum ovale (P.ovale) or, according to another classification, Malassezia furfur, Pityrosporum orbicultonifterophytrermif, Trich, Trich spp., Microsporum lanosum, Microsporum ferrugineum.

The interaction of the polyguanidine compound and α-hydroxy acid in a mass ratio of 1: 1 helps, on the one hand, stabilize the composition of anti-dandruff shampoo to microbial and fungal infections, exfoliation, and on the other hand, gives it a therapeutic effect: fungicidal, mycostatic, antiseborrheic, antiseptic , softening (due to the regulation of the electric charge of the hair), remove inflammatory skin reactions.

A synergistic mixture of polyguanidine and α-hydroxyacids, on the one hand, facilitates the separation of flakes, regulates the release of sebum, relieves itching, and on the other hand, exhibits high fungicidal activity. In addition, the presence of the above mixture in the shampoo promotes the regeneration and renewal of skin cells, moisturizes the skin, and regulates pH.

Guanidine polymer compounds belong to thermostable polymers with high prolonged activity, in addition, they are cationic surfactants, therefore they are well “attracted” to negatively charged hair and fix dietary supplements on the hair. Since the damaged areas of the hair have a large negative charge, more cationic particles are fixed on them and the cosmetic effect is enhanced.

Used lactic acid (C ₃ H ₆ O ₃ ) with a molecular weight of 90.1 is a colorless crystalline substance, readily soluble in water, ethanol. Use lactic acid manufactured by GALACTIC (Belgium). You can also use lactic acid GOST 490-79.

Citric acid α-hydroxytricarboxylic acid - C ₆ H ₈ O ₇ (mol. Mass 192,12) is a colorless crystal that is readily soluble in water, ethanol, diethyl ether and is an important metabolic product in living organisms (GOST 908-79) .

Glycolic acid (mol. Mass 76.05) is a colorless crystalline substance, readily soluble in water, alcohol, and ether. Contained in unripe grapes, beets, sugarcane (TU 6-14-714-82).

Malic acid (mol. Mass 134.1) is a colorless crystalline substance, readily soluble in water, ethanol, and ether. Malic acid is found in acidic fruits, such as unripe apples, gooseberries, rowan fruits, and rhubarb. It is used in the production of wines, fruit water and confectionery as a flavoring additive (TU 6-55-221-998-88).

Used as a buffer in the composition of anti-dandruff shampoo, the sodium salt of lactic acid ensures the creation of acid-base properties in the pH range of 4-10 for the optimal effectiveness of all the components that make up the shampoo and reduce skin irritation when using the shampoo. Use sodium lactate (Na-salt of lactic acid) manufactured by GALACTIC (Belgium). If necessary, you can use sodium citrate (Na salt of citric acid), used in the food industry as a flavoring substance, as a component of many drugs, anticoagulant (GOST 3652), sodium malate (Na salt of malic acid).

Perfume composition is an oily liquid with a characteristic odor.

Use a perfume composition with the following odor: apple, peach, apricot, banana, vanilla, cherry, grapefruit, jasmine, honeysuckle, cocoa, cinnamon, kiwi, lavender, lily of the valley, lemon, lime blossom, mango, chamomile, calendula, green tea, fruit -floral and fruit-grassy (mint, burdock, St. John's wort, rosemary, wormwood, eucalyptus, sage, thyme, hops, violet, string).

Manufacturing firms: CFF (Italy), "Bell flowers and fragrances" (Germany), or AOZT "Phytotechnology" (St. Petersburg).

The quantitative content of the components of the shampoo is optimal and is selected on the basis of numerous experiments. Table 1 presents data confirming the optimality of the declared limits.

The process for preparing dandruff shampoo has the following steps. The first - preparation of raw materials and equipment - includes checking the purity of the mixing reactor and weighing the ingredients. The second stage is the dispersion of polyethylene glycol in water for 30 minutes at a temperature of 35-40 ° C with periodic mixing of the mass. The mixing mode and design features of the reactor should prevent foaming.

The third stage is the sequential introduction of a weighed amount of ethoxylated ester of aliphatic alcohol (n = 2-5), ethoxylated ester of aliphatic alcohol (n = 8-20), coconut diethanolamide, coconut fraction, cocoamidopropyl betaine with stirring into the resulting dispersion. The mixture is stirred for 2 hours until a homogeneous viscous mass is obtained.

The fourth stage — the preparation of a synergistic mixture of the polyguanidine compound and α-hydroxy acid in a weight ratio of 1: 1 — involves the preparation of an aqueous solution of the polyguanidine compound in the mixer at a temperature of 30–40 ° C for 1.5–2 hours and the introduction of a weighted amount of α into the resulting solution hydroxyacids. To the resulting synergistic mixture is added Na-salt of lactic acid.

The fifth stage is the mixing of components in a reactor-mixer, which is a cylindrical container with a thermostatically controlled stainless steel jacket with a ratio of diameter and height of 1-1.5: 1-2, equipped with a removable cover, inlet fittings and an anchor or turbine type mixer. The prepared homogeneous viscous solution obtained as a result of the third stage of the process, an aqueous solution of a synergistic mixture of a compound of polyguanidine and α-hydroxy acid, Na-salt of lactic acid and perfume composition are poured into the reactor. Water is added to the resulting mass and stirred continuously at a temperature of 25-30 ° C for 1 hour.

The resulting shampoo is a homogeneous gel-like composition with a prolonged effect, with a disinfecting and therapeutic effect.

Example 1. Shampoo composition for dry hair

Ingredients wt.% hydroxyethylated ether of aliphatic alcohol (n = 2) 10.0 coconut fraction diethanolamide carboxylic acid 4.0 cocoamidopropyl betaine 2.0 polyethylene glycol PEG 40 2.0 poly- (4.9 dioxadodecanguanidine) chloride 0.2 lactic acid 0.2 Na salt of lactic acid 1,0 perfume composition 0.1 water rest

The use of shampoo cleanses the skin from dandruff, relieves irritation and itching of the scalp, moisturizes the skin, relieves static electricity, reduces the "fly" of the hair, does not dry the skin and does not upset the pH balance.

Example 2. The composition of the shampoo for normal hair

Ingredients wt.% hydroxyethylated ether of aliphatic alcohol (n = 8) 12.0 coconut fraction diethanolamide carboxylic acid 3.0 cocoamidopropyl betaine 4.0 polyethylene glycol PEG 75 4.0 poly- (4.9 dioxadodecanguanidine) phosphate 0.5 lemon acid 0.5 Na salt of lactic acid 1,0 perfume composition 0.5 water rest

The use of shampoo cleanses the skin from dandruff, relieves irritation and itching of the scalp, optimally moisturizes the skin, protects the hair from excessive drying, and removes static electricity.

Example 3. The composition of the shampoo for oily hair

Ingredients wt.% hydroxyethylated ether of aliphatic alcohol (n = 20) 16,0 coconut fraction diethanolamide carboxylic acid 2.0 cocoamidopropyl betaine 10.0 polyethylene glycol PEG 400 6.0 pgmg citrate / formate 1,0 glycolic acid 1,0 Na salt of lactic acid 1,0 perfume composition 0.5 water rest

The use of shampoo cleanses the skin from dandruff, relieves irritation and itching of the scalp, normalizes the release of sebum, relieves static electricity, improves the general condition of the skin.

Alternative features of claim 2 and 3 of the claims provide the same technical effect as shown in table 1.

After preparing the shampoo, the compositions No. 1, 2, 3, 4, 5 and 6 (table 1) were tested for stability. Samples of the shampoo compositions were stored at a temperature of 30 ° C for 24 months. After the specified period, studies were carried out on the percentage of polyguanidine compounds by the photocalorimetric method. Studies have shown that the polyguanidine content has remained unchanged, and the composition of the shampoo has not undergone delamination. This suggests a high stability of the composition of the shampoo.

Table 1
The components of the shampoo, wt.% Example No. Surfactant Oksietilir. ef. alif. alcohol ^**** Diethanolamide Cocoamidopropyl Betaine PEG GHG compounds ^** α-hydroxy acid ^*** Na salt of lactic acid Parf. composition Water Note (n = 2-5) (n = 8-20) Fd HD C / F PHMG one 2 3 four 5 6 7 8 9 10 eleven 12 13 fourteen one 10.0 n = 2 hp - 4.0 2.0 2.0
PEG 40 - 0.2 - 0.2 m. 1,0 0.1 Ost. Shampoo of a homogeneous gel-like composition with a prolonged disinfecting effect and therapeutic effect. 2 - 12.0 n = 8 hp 3.0 4.0 4.0
PEG 75 0.5 - - 0.5-hp 1,0 0.5 Ost. 3 - 16.0 n = 20 p.s. 2.0 10.0 6.0
PEG 400 - - 1,0 1.0 g. 1,0 0.5 Ost. four 16.0 n = 3 hp - 0.5 0.5 6.0
PEG 40 - 0.1 - 0.2-hp 0.5 0.3 Ost.

Keeps composition stable for 2 years. 5 4.0 n = 5 p.s. - 10.0 8.0 3.0
PEG 180 0.8 - - 2.0-hp 0.8 0.4 Ost. 6 - 10.0 n = 18 hp 1,0 6.0 2.0
PEG 240 - - 0.5 0.5-i.k. 0.6 0.4 Ost. 7 3.5 ^* n = 5 hp - 8.0 6.0 2.0
PEG 240 - 0.8 - 2.0-hp 0.5 0.5 Ost. Insufficient viscosity

Continuation of table 1 one 2 3 four 5 6 7 8 9 10 eleven 12 13 fourteen 8 16.5 ^* n = 5 m.s. - 8.0 6.0 2.0
PEG 240 - 0.8 - 2.0-hp 0.5 0.5 Ost. High foaming 9 - 16.0 n = 12 hp 0.2 ^* 6.0 6.0
PEG 180 - 0.8 - 1.0 m. 1,0 0.5 Ost. Insufficient thickening 10 16.0 n = 12 hp 10.5 ^* 6.0 6.0
PEG 180 - 0.8 - 1.0 m. 1,0 0.5 Ost. High foaming eleven 10.0 n = 5 f.s. - 8.0 0.25 ^* 4.0
PEG 180 - - 0.8 1.0 m. 1,0 0.5 Ost. Unprofitable look, weak. air conditioning. Effect 12 10.0 n = 5 f.s. - 8.0 10.5 ^* 4.0
PEG 180 - - 0.8 1.0 m. 1,0 0.5 Ost. Adhesive composition, non-marketable appearance 13 10.0 n = 5 f.s. - 8.0 6.0 1.5 ^* PEG 180 - - 0.8 1.0 m. 1,0 0.5 Ost. Lack of moisture fourteen 10.0 n = 5 f.s. - 8.0 6.0 6.5 ^* PEG 180 - - 0.8 1.0 m. 1,0 0.5 Ost. Shampoo exfoliates fifteen 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.05 ^* - 1.0 m. 1,0 0.5 Ost. Inadequate healing and biocidal properties 16 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 1.2 ^* - 1.0 m. 1,0 0.5 Ost. Unreasonably high connection costs. PG

Continuation of table 1 one 2 3 four 5 6 7 8 9 10 eleven 12 13 fourteen 17 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 0.1 ^* m.k. 1,0 0.5 Ost. No exfoliating effect eighteen 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 2.1 ^* -m.k. 1,0 0.5 Ost. Irritating effect of shampoo 19 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 1.0 m. 0.25 ^* 0.5 Ost. High pH Shampoo twenty 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 1.0 m. 1.1 ^* 0.5 Ost. Inadequate pH of the shampoo 21 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 1.0 m. 1,0 0.05 ^* Ost. No flavor 22 10.0 n = 5 f.s. - 8.0 6.0 4.0
PEG 180 - 0.8 - 1.0 m. 1,0 0.6 ^* Ost. Pungent flavor ^* - Examples that go beyond the declared limits;
^** - PG - polyguanidine compounds:
PD - poly (4,9-dioxadodecanguanidine) phosphate;
HD - poly (4,9-dioxadodecanguanidine) chloride;
C / F - citrate / formate PGMG; ^*** - α-hydroxy acid:
m.k. - lactic acid;
g.k. - glycolic acid;
l.k. - lemon acid;
y.k. - Apple acid.
^**** - lph.s - lauric alcohol fraction
mf.s - myristin fraction of alcohol
pf.s - palmitic fraction of alcohol

Claims (3)

1. Anti-dandruff shampoo, including a disinfectant, cocoamidopropyl betaine, a perfume composition and water, characterized in that a polyguanidine compound is used as a disinfectant and additionally contains an ethoxylated aliphatic alcohol ester (n = 2-5) or an ethoxylated aliphatic alcohol ester (n = 8-20), coconut fraction carboxylic acid diethanolamide, PEG polyethylene glycol (40-400), α-hydroxy acid and lactic acid sodium salt in the following ratio, wt.%: Ethoxylated aliphatic alcohol ester (n = 2-5) or ethoxylated ester of aliphatic alcohol (n = 8-20) 4.0-16.0 Coconut fraction diethanolamide carboxylic acid 0.5-10.0 Cocoamidopropyl Betaine 0.5-10.0 Polyethylene glycol PEG (40-400) 2.0-6.0 Polyguanidine Compound 0.1-1.0 α-hydroxy acid 0.2-2.0 Sodium Lactic Acid 0.5-1.0 Perfumery composition 0.1-0.5 Water Rest 2. Dandruff shampoo according to claim 1, characterized in that poly- (4,9-dioxadodecane-guanidine) phosphate, or poly- (4,9-dioxadodecanguanidine) chloride, or citrate / formate polyhexamethylene guanidine is used as the polyhuanidine compound. 3. Dandruff shampoo according to claim 1, characterized in that as α-hydroxy acid use lactic acid, or glycolic acid, or citric acid, or malic acid.