RU2286139C1 - Anti-blackhead cream - Google Patents

Abstract

FIELD: cosmetic, in particular agents for face and body skin care.

SUBSTANCE: claimed cream contains cosmetic base, ephthyderm, malavit, dichlofenac, calendula tincture, cedar oil, eucalyptus oil, juniper oil, tea tree oil. Riboflabin (Vitamin B2), lydase. All components are used in specific ratio.

EFFECT: cream with enhanced antiinflammation, resolving, and reparative action against empyesis and skin cicatrical changes, and for prevention of skin aging.

2 tbl

Description

The invention relates to cosmetics, namely to means for skin care of the face and body, and is mainly aimed at increasing anti-inflammatory, absorbable and reparative effects, elimination of pustular rashes and cicatricial changes in the skin.

Skin cosmetics are known which contain the active substance and various additives. So, body skin cream according to the patent of the Russian Federation No. 2156515, A 61 K 7/48, 2000 contains an active substance from a number of ethylidene diphosphonic acid derivatives, and as additives - mineral oil, vegetable oil, emulsion wax, monoglycerides and / or glycerol monostearate, cosmetic stearin, anhydrous lanolin, triethanolamine, weak organic acid, vitamins, preservative, perfume and water. However, it is not intended to eliminate and heal pustules and cicatricial changes in the skin, i.e. does not have a pronounced anti-inflammatory, absorbable and reparative effect.

Closest to patentable is a cream for the skin of the body and face, which is given the name "Malavtilin" (Patent for the invention of the Russian Federation No. 2189808, registered September 27, 2002, - prototype). Malavtilin is produced by the LLC Medical and Diagnostic Firm MEDIK, Yekaterinburg (License registration number PK10.V00256. Certificate of Conformity No.POCC.RU.PC10.A00256 No. 3620511 dated October 21, 1999).

Specified as a prototype cream, including the basis of efthillin (contains eftederm - 40.0; petrolatum - 40.0; lanolin - 5.0; ethyl alcohol 95% -5.0; eufillin - 0.5; water - 9.5) , Eleutherococcus extract, Malavit, diphenhydramine, diclofenac, castor oil, glycerin, flavor, proteolytic enzyme. The cream has anti-inflammatory, antiseptic and analgesic effects; prevents aging of the skin, reduces the number of wrinkles, heals minor injuries. However, the following are included in the composition of eptillin: ethyl alcohol, which has an irritating effect; lanolin and petrolatum, often causing allergic reactions and skin irritation (petrolatum). The cream is not intended for problem skin, to eliminate pustular rashes and cicatricial changes.

The technical task is to improve the quality of the cream by eliminating ethyl alcohol, petroleum jelly and lanolin from its composition; increased anti-acne (anti-inflammatory, absorbable and reparative) action aimed at eliminating pustular rashes and cicatricial changes in the skin due to the introduction of ingredients into the cream, which, due to the percutaneous activity of the eftederm, quickly penetrate into all layers of the skin, prolonging and enhancing their effect several times .

In an anti-acne cream, a cosmetic base with eftederm is used instead of an eptillin base.

The technical result is achieved by the fact that the anti-acne cream, including castor oil, malavit, diclofenac, a proteolytic enzyme and a base containing eftederm, water and aminophylline, additionally contains a cosmetic base, tincture of calendula; oils: juniper, eucalyptus, cedar, tea tree, riboflavin (vitamin B ₂ ) in the following ratio, wt.%:

malavit 1.00-5.00 diclofenac 0.10-0.50 tincture of calendula 0.10-0.50 juniper oil 0.02-0.30 eucalyptus oil 0.02-0.20 Cedar oil 0.01-0.15 tea tree oil 0.01-0.15 riboflavin (vitamin B ₂ ) 0.01-0.15 proteolytic enzyme lidase, PE 0.50 PE-5.00 PE eftederm 10.00-25.00 cosmetic base rest

Malavit has anti-inflammatory, antiseptic and analgesic effects. When its content in the proposed composition is less than 1.0%, the effect is negligible, and when the content is more than 5.0%, the analgesic effect prevails, the desired effect is practically not amplified and there is a danger of a toxic effect.

Diclofenac - refers to a non-steroidal anti-inflammatory drug - NSAIDs, has anti-inflammatory, analgesic and antipyretic effects. With its content of less than 0.1%, the effect is negligible, and with the content of more than 0.5%, the analgesic and antipyretic effect prevails.

Calendula tincture is an adaptogen that has antioxidant, antimicrobial, anti-inflammatory and soothing effects. With its content of less than 0.10%, the effect is negligible, and with the content of more than 0.50%, the hypnotic effect prevails, accompanied by a decrease in blood pressure.

Juniper oil is an adaptogen that has antioxidant, anti-inflammatory and antiseptic effects. With a content of less than 0.02%, its effect is negligible, and with a content of more than 0.30%, the cosmetic effect does not increase, but the smell sharply intensifies.

Eucalyptus oil is an adaptogen that has antioxidant, antimicrobial, anti-inflammatory and deodorizing effects. With its content of less than 0.02%, the effect is negligible, and with the content of more than 0.20%, the effect is practically not enhanced, but the smell of cream intensifies sharply.

Cedar oil is an adaptogen, has anti-inflammatory, reparative, tonic and antiseptic effects, significantly increases the body's resistance, has a pleasant smell of pine needles. When its content is less than 0.01%, the effect is reduced, and when it contains more than 0.15%, the effect is not enhanced, but the smell of cream intensifies sharply.

Tea tree oil is an adaptogen, has anti-inflammatory, reparative and deodorizing effects, significantly improves skin elasticity and turgor. With its content of less than 0.01%, the effect is negligible, and with a content of more than 0.15%, the effect is practically not enhanced, but the smell of cream intensifies sharply.

Riboflavin (vitamin B ₂ ) - after biotransformation into coenzyme forms (the process is significantly accelerated in the presence of the eftederm), riboflavin is involved in tissue respiration, normalizes the metabolism of fats, carbohydrates, porphyrins, amino acids, trace elements, enhances blood formation, increases reparative processes, including skin, increases the antimicrobial effect of drugs. With its content of less than 0.01%, the effect is negligible, and with the content of more than 0.15%, the effect is hardly enhanced (the difference is not significant).

Lidase is a proteolytic enzyme that contains hyaluronidase. It has a resolving effect, quickly increases the permeability of tissues to biologically active substances. Improves the movement of fluids in interstitial spaces. If its content is less than 0.50 PE, the effect is insignificant, and if it contains more than 5.00 PE, the membrane permeability sharply increases, and the desired effect is not enhanced.

The cosmetic base contains: 20% eftederm, it is at this concentration that the properties that determine its effect are most pronounced.

Eftiderm is a transdermal conductor of biologically active substances; it easily passes them into tissues. It is an NSAID, has an antioxidant and decongestant effect, increases cell viability, acts on enzymatic systems of biological membranes, which leads to an increase and prolongation of the cosmetic and therapeutic effect of all components of the composition. There is a decrease in the production of prostaglandins, histamine, bradykinin, the number of allergic and toxic complications; increased local immunity; skin metabolism normalizes.

Vegetable and castor oils are the oil phase of the cosmetic base. Cetylstearyl alcohol is a viscosity modifier. Romulgin is a co-emulsifier.

Aminol is an emulsifier. Solbrol is a preservative. Eufillin has a vasodilating and decongestant effect.

Thus, the rapid holding of all the components of the proposed composition in the tissue by the eftederm prolongs the action of the cream up to 20-22 hours, helps to normalize metabolic processes and improves blood circulation to all skin structures, helps to increase local immunity.

The technical result is achieved by the fact that the anti-acne cream, including castor oil, malavit, diclofenac, a proteolytic enzyme and a base containing eftederm, water and aminophylline, additionally contains a cosmetic base, tincture of calendula; oils: juniper, eucalyptus, cedar, tea tree, riboflavin (vitamin B ₂ ) and dalargin, helps to increase the anti-acne (anti-inflammatory, absorbable and reparative) action aimed at preventing and eliminating pustular rashes and cicatricial changes in the skin, improving quality.

The following ingredients are used to make the patented anti-acne cream:

- malavit according to TU 9158.001.29731500-95,

- diclofenac according to ND 42-4557-95,

- tincture of calendula according to GF XI, Article 5,

- juniper oil - according to the current scientific and technical documentation,

- eucalyptus oil according to GF X, Art. 475,

- cedar oil - according to the current scientific and technical documentation,

- tea tree oil - according to the current NTD,

- riboflavin (vitamin B ₂ ) according to GF X, Art. 585,

- proteolytic enzyme lidase according to TU 9291-003-49959837-99,

- a cosmetic base with an eftederm according to GOST 29189-91.

To obtain a cream, 75% of the required amount of cosmetic emulsion base is loaded into a boiler with a stirrer. Each dry ingredient that is part of the cream is weighed on the analytical balance in the right amount, rubbed into the smallest powder, sieved through a No. 36 sieve, then thoroughly rubbed with a cosmetic emulsion base in a ratio of at least 1:10 and introduced into the boiler, followed by stirring for 5 -7 minutes (each ingredient separately). In the resulting mass, alternately with constant stirring, add the liquid ingredients in the right amount, add the base to the right amount and mix thoroughly for 25-40 minutes until a homogeneous mass of white or white with a yellowish or greenish tint and a smell corresponding to the ingredients used is formed.

The composition of the cream for comparative clinical trials are shown in tables 1,2.

Table 1 Composition of anti-acne cream in clinical trials №№p / p Components Composition wt.% one 2 3 4-malavtilin one Malavit 3.00 5.00 2 Diclofenac 0.25 0.25 3 Tincture of calendula 0.25 - four Juniper oil 0.05 0.10 5 Eucalyptus oil 0.05 3.6 - 6 Cedar oil 0,025 0.01 0.15 7 Tea tree oil 0,025 - 8 Riboflavin 0.05 0.01 0.15 - 9 Proteolytic enzyme, PE 2Pelidase 0.50 PE lidase 5.00 PE Lidase 5.00 PE Phytopain 10 Eftiderm 10.00 15.00 25.00 - eleven Cosmetic base 96,299 96.3545 96.0985 94.50

Notes.

1. Previously, experimental studies on animals were carried out, as a result of which it was found that all the compositions listed in the table do not have acute and chronic toxicity, local irritant effects, do not cumulate, are not potential allergens.

2. In preliminary studies, optimal concentrations of eftederm, malavite, diclofenac, tincture of calendula, juniper oil, eucalyptus oil, tea tree oil were found.

3. The compositions 1, 2, 3 with different contents of cedar oil, riboflavin, lidase and dalargin were studied in comparison with the prototype.

Comparative clinical studies were conducted on 40 volunteers (women and men equally) aged 18-30 years in 4 groups equally. The research results are presented in table 2. For men and women, the difference in indicators was unreliable, therefore, the combined data for each group are presented in the table.

All patients complained of a significant number of painful acne on the face and a small amount in the back, moderate swelling and hyperemia in the area of the rash. On the face and back, a moderate amount of small scars of bluish-pink color remaining after the healing of pustules. There are no large (more than 5-7 mm in diameter) pustules. In 92% of patients, the disease arose between the ages of 12 and 16 years, in 8% after infectious diseases at the same age. All were periodically treated with various means with a temporary effect. At the initial examination, the pH of the skin of the face in all patients was 6.8-7.4.

A cream corresponding to the group was applied to the rash area 2 times a day for 30 days.

Registration of indicators was carried out before using the cream, on the 3rd, 7th, 14th, 21st and 30th day of observation. In the process of research, skin type, its turgor, the presence of rashes, skin pH were assessed, history, complaints were clarified. All studies were carried out according to generally accepted methods.

table 2 Research results Name of symptoms Symptoms 1 group 2 group 3 group 4 group Eliminated in = days % Eliminated in = days % Eliminated in = days % Eliminated in = days % Pustular elements one hundred 14-18 one hundred thirty 60 thirty 70 thirty 70 Scarring one hundred thirty 80 thirty thirty thirty fifty thirty 40 Skin elasticity and turgor one hundred thirty 150 thirty 120 thirty 140 thirty 130 Note: all manifestations of acne before the start of the study are taken as 100%.

The following results were obtained: in patients of the 1st group, remission occurred on the 14-18th day, by the 30th day shallow scars up to 4 mm in size completely resolved, the larger ones became pale pink, decreased in size; complexion has improved; skin elasticity and turgor increased by 50%, pH decreased to 5.3-5.8.

In group 2, the effect was significantly lower: on day 30, the number of rashes and / or their size decreased by 60%, and scarring - by 30%; slightly improved complexion; the elasticity and turgor of the skin increased by 20%, the pH decreased to 6.2-6.8.

In groups 3 and 4, by day 30, the number of rashes and / or their size decreased by 70%; moderately improved complexion. However, in patients of group 3, the number and depth of scars decreased by 50%; skin elasticity and turgor increased by 40%; skin pH decreased to 5.8-6.1. The same indicators of 4 groups (prototype) on day 30 were 20% and 20%, and the pH was 6.5-7.0.

So, patentable anti-acne cream (composition I), additionally containing a cosmetic base, tincture of calendula; oils: juniper, eucalyptus, cedar, tea tree, riboflavin (vitamin _B2) and dalargin, efficient prototype exhibits anti-inflammatory, resolving and restorative action aimed at addressing the pustular rash and scarring of the skin changes, eliminates puffiness, normalizes microcirculation, increases turgor and skin elasticity, lowers pH, which helps prevent the occurrence and elimination of acne rashes and scars;

improves the quality of the cream.

Thus, “Anti-acne cream” is proposed for patenting, combining cosmetic and medicinal properties, based on the use of non-deficient ingredients of natural and organic origin.

The proposed cream meets the criteria of novelty, non-obviousness and industrial applicability, in connection with which it is proposed to legal protection by a patent for an invention.

Claims (1)

An eftederm-based anti-acne cream containing malavit, diclofenac, aromatic oils, characterized in that it additionally contains calendula tincture, a cosmetic base, with juniper, eucalyptus, cedar, and tea tree oils, and riboflavin ( vitamin B ₂ ) and lidase in the following ratio of components, wt.%: Eftiderm 10.00-25.00 Malavit 1.00-5.00 Diclofenac 0.10-0.50 Tincture of calendula 0.10-0.50 Juniper oil 0.02-0.30 Eucalyptus oil 0.02-0.20 Cedar oil 0.01-0.15 Tea tree oil 0.01-0.15 Riboflavin (Vitamin B ₂ ) 0.01-0.15 Lidase, PE 0.50 PE-5.00 PE Cosmetic base Rest