RU2272549C2 - Nonalcoholic tonic beverage "pokhmelator" - Google Patents

Abstract

FIELD: food processing industry.

SUBSTANCE: invention relates to agent used for arresting the alcohol withdrawal syndrome. Nonalcoholic tonic beverage "Pokhmelator" comprises the following components per 1 l of beverage: 0.01-4.0 g of vitamins; 0.01-5.0 of caffeine-containing components; 0.05-10.0 g of taste-aromatic supplement, and natural mineral water or artificially mineralized water, the balance, up to 1 l. Except for, the beverage comprises additionally extracts and/or herbal infusions in the concentration 1.0-10.0 g/l possessing detoxifying, immunostimulating and sobering effect, 0.1-20.0 g/l of mineral saline supplement and 0.01-1.0 g/l of succinic, lactic, pyruvic or citric acid, or their mixtures taken in any ratios. As source of vitamins the beverage comprises water-soluble vitamins or vitamin premix for beverages. Proposed invention provides decreasing the beverage dose by 2-3 times as compared with the known one for improvement of psychosomatic state all person suffering from alcohol withdrawal syndrome for the first 1.5-2 h after the beverage dosing.

EFFECT: enhanced effectiveness and valuable properties of beverage.

5 cl, 10 ex

Description

The invention relates to food industry and medicine, and relates to a means for stopping acute alcohol intoxication in domestic drinking and treatment of alcoholic hangover syndrome in alcoholism.

The occurrence of a subjectively unpleasant psychophysical state on the day after massive alcohol consumption is known. This condition is associated with a violation of the water-electrolyte balance, intoxication with alcohol decay products. In narcology, the condition after acute alcohol intoxication is classified as post-toxic syndrome and is subject to active therapy only in severe cases that threaten the patient's life, and is limited to symptomatic agents. However, patients who have abused alcohol the day before and then suffer from alcohol intoxication use various folk remedies, such as cabbage or cucumber pickle, strong tea or coffee, kefir, milk, etc. to alleviate their condition. It is known to use 20 drops of peppermint tincture in a glass of cold water, while the general condition is alleviated, headaches are reduced (G.Z. Minenjyan. Collection of traditional medicine and alternative methods of treatment. M., Tekhnoekos, 1991. - 220-221).

The disadvantage of these funds is that they are not always effective and the desired effect is not achieved.

Known pharmaceutical composition for the prevention, treatment of intoxication and alcohol withdrawal syndrome, containing succinic acid (0.1-0.3 g) and citric acid (0.025-0.85 g). This composition should be taken 3-5 times a day at the rate of 3-5 mg / kg body weight (RF patent 2039556, IPC 6 A 61 K 31/19, publ. 07.20.95). The specified drug can be used in domestic conditions. It stimulates metabolic processes, has an antitoxic effect, due to increased excretion of alcohol from the body.

However, the above composition is most appropriate to use before the development of post-toxic alcohol syndrome, since in a hangover state the activation of the process of elimination of alcohol is not relevant.

Known anti-alcohol composition based on biological material containing, along with citric and succinic acids, more than 80 different natural components (UK Application N2198041, IPC 6 A 61 K 31 / 19.5, publ. 1987). The specified composition is used as a biologically active additive in the manufacture of alcoholic and non-alcoholic drinks, has an antitoxic effect and reduces alcohol consumption.

However, this additive has a high cost, its production is limited by the raw material source.

The well-known drug Alka-Seltzer of the English company Miles, containing (per 1 tablet) as an active principle, acetylsalicylic acid in an amount of 0.324 g and as auxiliary substances 0.965 g of citric acid and 1.625 g of sodium bicarbonate (Leaflet for the drug Alka- Seltzer, Miles, England). The drug is used during acute intoxication.

However, this drug can be used only sporadically, with household alcohol consumption. The long-term use of the Alko-Seltzer drug for detoxification, which patients with alcoholism regularly need, leads to serious consequences due to the presence of aspirin in the drug: dyspeptic symptoms, changes in the gastric mucosa, impaired nervous system function and hemocoagulation processes.

It is known to use the infusion of nettle dioica as an anti-alcoholic agent (RF Patent N2011382, IPC 6 A 61 K 35/78, publ. 04/30/94). The tool reduces alcohol intoxication.

However, the infusion of nettle dioica has an insufficiently pronounced effect in eliminating the effects of acute and chronic alcohol intoxication.

Known drug "Drug" for the treatment of alcohol dependence, which is a crushed mass with a particle size of 500-750 microns and including, parts by weight: thyme herb 15-25; grass and inflorescences yellow flyweed 15-25; rhizome rhizomes sofroloid 8-15; centaury grass 8-15; bearberry grass 8-15; tansy inflorescences 8-15; wormwood grass 8-15; European Clefthoof Grass 5-10 (RF patent N2040271, IPC 6 A 61 K 35/78, publ. 07.27.95).

However, the drug "Narcodel" is used to treat alcoholism, but does not have a pronounced sobering and detoxifying effect.

Known sobering collection "Trezleuton", including, wt.%: Thyme herb - 2.0; grass of dried marshmallow - 18.0; St. John's wort grass -18.0; rose hips - 18.0; peppermint leaves - 4.0; oregano grass - 4.0; rhizomes with the roots of sofrolloid levzea - 36.0 (RF Patent N 2129008, IPC 6 A 61 K 35/78, publ. 04/20/99).

However, the collection is used to sober up people who drink alcohol, but does not have a pronounced detoxifying effect.

Known drug for the relief of alcohol withdrawal syndrome, including water in an amount of 1 l, sodium chloride (3.0-7.0) g, glucose, fructose or sucrose (10.0-15.0) g, citric acid (2.0 -6.0) g, ascorbic acid (1.0-4.0) g, 96% ethyl alcohol (8.0-25.0) g (RF patent No. 2086237, IPC 6 A 61 K 31/045 , publ. 1997). It is preferable to use the aforementioned means to interrupt drunken conditions and improve overall health in these conditions.

However, this agent has a mild detoxifying effect. Improving subjective sensations, this remedy cannot normalize impaired body functions in a fairly short time. In addition, this tool can only be used to stop withdrawal symptoms of alcoholics, because it contains ethyl alcohol, which causes disgust in people who do not have alcohol addiction.

Known means (in the form of a drink) for the relief of alcohol withdrawal symptoms, including water, artificially dissolved salt additives, caffeine and vitamins. As salt additives, use a balanced salt mixture containing sodium, potassium, calcium and magnesium salts with a certain ratio of components (RF patent 2167655, IPC A 61 K 31/375, publ. 05.27.2001).

However, the specified artificially prepared mixture of salt components, dissolved in the drink, is not sufficient for the effective removal of the hangover syndrome.

The prototype of the invention is a non-alcoholic drink for relieving a hangover syndrome (RF patent 2150871, IPC A 23 L 2/39, publ. 06/20/2000), including water, artificially dissolved salt additives and herbs with detoxifying, immunostimulating and sobering action.

However, even such an artificially prepared mixture of salt components, dissolved in a soft drink, is not sufficient to effectively relieve a hangover syndrome.

The technical result of the invention is the use of an aqueous base with a more balanced composition of salts, providing an increase in the effectiveness of the removal of a hangover syndrome, as well as the creation of such a cheap and affordable drink that would have high organoleptic and detoxification properties, would ensure the normalization of impaired body functions in a shorter time household intoxication with alcohol and with a hangover syndrome both in alcoholics and in people without alcohol dependence.

The specified technical result is achieved by the fact that it is proposed the use of natural or artificially mineralized mineral water with a total salt content of at least 0.8 g / l as the aqueous base of the drink for relieving a hangover syndrome.

The indicated technical result is also achieved by the fact that in the Hangover drink for relieving a hangover syndrome, which includes vitamins, a caffeine-containing component, a flavoring additive and an aqueous base, according to the invention, it contains natural or artificially mineralized mineral water with a total salt content of at least 0.8 g / l with the following content of components, g / l:

vitamins 0.01-4.0 caffeinated component 0.01-5.0 flavoring additive 0.05-10.0 natural or artificially mineralized mineral water with a total content salts of at least 0.8 g / l the rest is up to 1 liter

The hangover drink for relieving a hangover syndrome additionally contains extracts and / or infusions of herbs that have a detoxifying, immunostimulating and sobering effect with the following components, g / l:

vitamins 0.01-4.0 caffeinated component 0.01-5.0 flavoring additive 0.05-10.0 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action 1.0-10.0 natural or artificially mineralized mineral water with a total content salts of at least 0.8 g / l the rest is up to 1 liter

The Hangover drink for relieving a hangover syndrome additionally contains a mineral salt supplement in the following ratio of components, g / l:

vitamins 0.01-4.0 caffeinated component 0.01-5.0 flavoring additive 0.05-10.0 mineral salt supplement 0.1-20.0 natural or artificially mineralized mineral water with a total content salts of at least 0.8 g / l the rest is up to 1 liter

The Hangover drink for relieving a hangover syndrome additionally contains succinic or lactic, or pyruvic, or citric acid with the following components, g / l:

vitamins 0.01-4.0 caffeinated component 0.01-5.0 flavoring additive 0.05-10.0 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action 0.1-10.0 amber or milk, or pyruvic, or citric acid 0.01-1.0 natural or artificially mineralized mineral water with a total content salts of at least 0.8 g / l the rest is up to 1 liter

As vitamins, the drink contains water-soluble vitamins, such as ascorbic acid, thiamine chloride or bromide, other B vitamins, or vitamin premix for drinks.

As a water base, it may contain the following natural medicinal or medicinal-table mineral waters (or mixtures thereof) with a total salt content of at least 0.8 g / l according to GOST 13273-88: Borjomi, Ucera, Avadhara and others, or TU: “Dovolenskaya”, “Duplenskaya”, “Karachinskaya” (Novosibirsk region) and others.

Artificial mineralized water “Siberian” GOST 28188-89 OKP 918547 can be used as a water base.

When using artificially mineralized mineral waters and natural mineral waters with a total salt content of less than 0.8 g / l, mineral salt additives or mixtures thereof (salts of Na, K, Ca, Mg, Br, B, J, Se and others or mixtures thereof).

As vitamin premixes, standard vitamin premixes for drinks are used, containing water-soluble vitamins such as ascorbic acid, thiamine (vitamin B1), riboflavin (vitamin B2), vitamin B6, niacin, folic acid, nicotinic acid and others.

A mixture of (Na +, K +, Ca ₂₊ and Mg ₂₊ ) and other salts in mineral water is similar to their content in human blood plasma. This ensures the most physiological effect of an aqueous solution of salts on the human body at the cellular level.

The proposed anti-alcoholic drink takes into account pathogenetic mechanisms leading to a painful psychosomatic state after taking a large dose of alcohol: increased irritability and excitability; violation of myocardial contractility, muscle disorders; headache, swelling, and thirst.

To relieve post-toxic syndrome in acute alcohol intoxication, the first anti-alcohol drug provides:

- an increase in the content of magnesium ions in the blood plasma, which reduces irritability, excitability, i.e. symptoms of damage to the central nervous system are eliminated;

- an increase in the content of potassium ions, which leads to the normalization of the contractility of the myocardium, tremor and other muscle disorders are eliminated;

- the redistribution of potassium and sodium ions inside and outside the cell is normalized, which eliminates edema and thirst, reduces the load on the liver and kidneys, and normalizes the work of enzyme systems.

With alcoholism, the exchange of potassium and calcium is disrupted, and the potassium and calcium salts in the proposed preparation make up for them. In addition, the presence of potassium, magnesium ions in the drug allows you to quickly relieve withdrawal symptoms in alcoholics.

Golden root extract (Rhodiola rosea) has a stimulating effect, helps strengthen the nervous system and improves performance.

Peppermint extract has a calming, antispasmodic and choleretic effect, reduces severity in the head and headaches.

Instant coffee stimulates the activity of the central nervous system and has a cardiotonic effect.

Peony root helps restore balance between the processes of excitation and inhibition in violation of their ratio, and also neutralizes acetaldehyde present in the blood.

Dioecious nettle grass has a sobering and antitoxic effect, improves memory and reduces alcohol tolerance. Succinic acid is a natural adaptogen.

Citric acid is a functionally active metabolite of the Krebs cycle, suppressed in conditions of post-toxic alcohol syndrome.

Thyme herb envelops the mucous membrane of the gastrointestinal tract, has an antispasmodic effect.

All components of the proposed drink are used in pharmaceuticals for internal use or are used in the food industry.

The following are examples of the composition of the drink "Hangover", g / l:

Example 1

vitamin C 0.1 caffeinated component (caffeine) 0.3 flavoring additive (cucumber) 1,0 natural medicinal table mineral Dovolenskaya water with a general content salts of at least 6 g / l the rest is up to 1 liter

Example 2

vitamin C 1,0 thiamine chloride 0.5

caffeinated component

(instant coffee) 5,0 flavoring additive (quinine) 0.01 natural medicinal table mineral Duplenskaya water with a total content salts of at least 2 g / l the rest is up to 1 liter

Example 3

vitamin C 1,0 thiamine chloride 0.3 caffeinated component (caffeine) 0.2 flavoring additive (lemon) 1,0 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action: Golden root 2.0 peppermint 5,0 artificially mineralized water "Siberian" with a general content salts of at least 0.8 g / l the rest is up to 1 liter

Example 4

vitamin premix for drinks 0.5 caffeinated component (instant coffee) 5,0 flavoring additive (grapefruit) 3.0 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action: Stinging nettle 1,0 peppermint 4.0 Rhodiola rosea 2.0 natural medicinal table mineral Karachinskaya water with a total content salts of at least 1.8 g / l the rest is up to 1 liter

Example 5

vitamin C 1,0 thiamine chloride 0.1 caffeinated component (caffeine) 0.1 flavoring additive (cucumber + celery) 2.0 mineral salt supplement (NaCl) 4.0 artificially mineralized water "Siberian" with a general content salts of at least 0.8 g / l the rest is up to 1 liter

Example 6

vitamin C 0.5 vitamin premix for drinks 1,0 caffeine 0.1 flavoring additive (wormwood) 1,0 mineral salt supplement 10.0 artificially mineralized water "Siberian" with a general content salts of at least 0.8 g / l the rest is up to 1 liter

Example 7

vitamin premix for drinks 1,0 caffeine 0.15 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action: Stinging nettle 2.0 peppermint 3.0 Rhodiola rosea 0.5 thyme 1,0 succinic acid 0.01 pyruvic acid 0.1 a mixture of natural medicinal table mineral waters "Magic Siberian-3" (GOST 13273-88) with total salt content not less than 2.4 g / l the rest is up to 1 liter

Example 8

vitamin C 0.5 sodium caffeine benzoate 0.1 flavoring additive (mint) 1,0 extracts and / or infusions of herbs having detoxifying, immunostimulating and sobering action peppermint 1,0 Rhodiola rosea 1,0 peony root 1,0 thyme 1,0 lemon acid 1,0 Karachinskaya water with a total salt content not less than 1.8 g / l the rest is up to 1 liter

Example 9. The method of preparation and use of the proposed soft drink

The beverage of example 1-8 is prepared as follows. First, the plant components of the drink are extracted in water by heating to 100 ° C per 1 liter. Then, salt additives, a flavoring additive and citric or succinic acid are dissolved in a hot infusion of herbs. The composition and quantity of the components taken depends on the severity of alcohol intoxication, the age and general health of the patient, which are selected from the compositions shown in examples 1-8. The prepared mixture is cooled to 7-10 ° C, diluted with natural mineral or artificially mineralized water in accordance with examples 1-8 and packaged in sterile plastic or glass containers with a capacity of 0.5-2.0 l and sealed with a lid.

The drink is recommended for the treatment of a hangover, i.e. to eliminate post-intoxication syndrome in acute alcohol intoxication, reduce the duration of the relief of a hangover.

The resulting soft drink is taken orally for 2-3 hours.

In addition, the proposed drink is recommended for use by persons not suffering from alcoholism, but often forced to drink alcohol.

Example 10. The study of the therapeutic and prophylactic properties of the soft drink "Hangover"

The proposed anti-alcohol remedy was tested in the treatment of patients suffering from household drunkenness, for the treatment of the condition after alcohol intoxication, only 100 people who applied for help to the treatment and rehabilitation center. Testing showed excellent and good results. A significant improvement in the psychosomatic state was noted in all patients in the first 1.0-2.5 hours of treatment. The symptoms of general intoxication disappeared, diuresis intensified, discomfort in the heart disappeared, mood, appetite and general well-being improved.

The proposed composition is not toxic and does not cause side effects. Studies have shown good tolerance to the drink, no complications and side effects were noted. This composition can be prepared in a pharmacy.

Industrial applicability. The proposed drink to eliminate the hangover syndrome can be prepared both in large food or pharmaceutical enterprises, and in pharmacies that have the appropriate equipment.

Claims (5)

1. A non-alcoholic drink for relieving a hangover syndrome, including vitamins, a caffeine-containing component, a flavoring additive and a water base, characterized in that it contains natural or artificially mineralized mineral water with a total salt content of at least 0.8 g / l when the following components, g / l: Vitamins 0.01-4.0 Caffeinated component 0.01-5.0 Flavoring additive 0.05-10.0 Natural or artificial mineralized mineral total water salts of at least 0.8 g / l The rest is up to 1 liter 2. The drink according to claim 1, characterized in that it further comprises extracts and / or infusions of herbs having a detoxifying, immunostimulating and sobering effect with the following components, g / l: Vitamins 0.01-4.0 Caffeinated component 0.01-5.0 Flavoring additive 0.05-10.0 Extracts and / or infusions of herbs, detoxifying immunostimulating and sobering action 1.0-10.0 Natural or artificial mineralized mineral total water salts of at least 0.8 g / l The rest is up to 1 liter 3. The drink according to claim 1, characterized in that it further comprises a mineral salt additive in the following ratio of components, g / l: Vitamins 0.1-4.0 Caffeinated component 0.01-5.0 Flavoring additive 0.05-10.0 Mineral salt supplement 0.1-20.0 Natural or artificial mineralized mineral total water salts of at least 0.8 g / l The rest is up to 1 liter 4. The drink according to claim 2, characterized in that it further comprises succinic, or lactic, or pyruvic, or citric acid or mixtures of these acids in any proportions with the following content of components, g / l: Vitamins 0.01-4.0 Caffeinated component 0.01-5.0 Flavoring additive 0.05-10.0 Extracts and / or infusions of herbs, detoxifying immunostimulating and sobering action 1.0-10.0 Amber or milk, or pyruvic, or citric acid, or their mixture in any ratio 0.01-1.0 Natural or artificial mineralized mineral total water salts of at least 0.8 g / l The rest is up to 1 liter 5. The drink according to claim 1, characterized in that as vitamins it contains water-soluble vitamins or vitamin premix for drinks.