RU2267331C1 - Disinfecting detergent composition - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: the suggested disinfecting detergent composition contains ortho-phenylphenol, ortho-benzyl-para-chlorine-phenol and water as ingredients for providing low toxicity level, sufficient solubility and transparency at obtaining efficient working solution, the composition is supplemented with propylene glycol, ethanol as solvents and stabilizers of aqueous solutions, in combination with lauryl sulfate as a detergent component, at a certain ratio of components. The innovation provides the chance to obtain disinfecting detergent composition being of sufficient solubility and transparency of aqueous solutions referring to the group of low-danger substances, of no sensitization and depigmentation of skin, of no acrid bad odor, and being of antimicrobial activity to the most resistant microorganisms, such as mycobacteria of tuberculosis, virus of poliomyelitis, fungicidal infections that enables to provide complete reliable disinfection of objects at the absence of harmful impact upon a man.

EFFECT: higher efficiency of application.

1 cl, 1 ex, 7 tbl

Description

The present invention relates to the production of a disinfecting detergent composition intended for disinfecting and cleaning surfaces in rooms, hard furniture, sanitary equipment, surfaces of devices and apparatuses, rubber mats in medical institutions, clinical, microbiological and other laboratories, sanitary transport, public utilities (hotels, hostels, hairdressers, baths, laundries, industrial markets, public toilets), institutions IAOD, culture, leisure, sports (swimming pools, cultural and recreation centers, offices, sport centers), social security institutions and prisons during bacterial infections, including tuberculosis, viral infections and fungal etiology.

A disinfecting composition is known in which the combination of ortho-phenylphenol with other phenol derivatives having higher antimicrobial properties makes it possible to obtain compositions that are active against St. Aureus, Ps. Aeruginosa bacteria, the limitations are the solubility of these components in water and therefore their availability for entry in contact with microorganisms [3].

Closest to the proposed disinfectant composition is a composition [4], consisting of the following components, are shown in table 1.

Table 1 Structure By weight% Sodium alkoxyethoxysulfate 9.60 9.60 9.60 Glycolic acid 12.60 12.60 12.60 Ortho-benzyl-para-chlorophenol 6.38 6.38 6.38 Para-tert-amylphenol 3.00 3.00 3.00 Ortho-phenyl-phenol 0.5 0.50 0.5 Isopropyl alcohol 12.00 - 8.00 Hexylene glycol - 10.00 4.00 Triethanolamine 1.00 1.00 1.00 Perfumery fragrance 0.50 0.50 0.50 Water 54.42 54.52 54.42

The disadvantages of the known composition are that para-tert-amylphenol is toxic and has the property of causing depigmentation of the skin and has a sensitizing effect [6, 7]; glycolic acid causes damage to the skin and mucous membranes of the respiratory tract and eyes [8], the composition has a sharp irritating odor, limited microbiological activity only against unstable bacteria, and insufficient solubility in water.

The technical result of the proposed invention is to obtain a disinfectant washing composition in the form of a concentrate, which belongs to the class of low-hazard substances (toxicity class 4), which has sufficient solubility in the preparation of aqueous working solutions with transparency, which does not have the ability to cause sensitization and depigmentation of human skin, which has antimicrobial activity and providing, when using one concentration of the working solution, the death of bacteria, including highly resistant microbes of tuberculosis, highly resistant polio viruses and fungi.

To achieve a technical result, a disinfecting washing composition is proposed, containing ortho-phenylphenol, ortho-benzyl-para-chloro-phenol and water as ingredients, characterized in that, to ensure low toxicity, sufficient solubility and transparency when obtaining a working solution, the composition is introduced propylene glycol and ethyl alcohol as solvents and stabilizers, in combination with lauryl sulfate as a detergent component.

Moreover, the quantitative content of the ingredients in the concentrate is (% by weight) of ortho-phenylphenol - 3.0-3.5%; ortho-benzyl-para-chloro-phenol - 2.6-3.2%; propylene glycol - 60-70%; ethyl alcohol - 5-10%; lauryl sulfate - 10-15% and water - 5-10%.

The concentration of aqueous working solutions of the proposed composition is from 0.5% to 3.0%.

The essence of the proposed invention.

An object of the present invention is to provide a disinfecting detergent composition based on ortho-phenylphenol and ortho-benzyl-para-chloro-phenol having chemical stability, good solubility in water and transparency at dilutions from 0.5% to 3.0%, low toxicity (not higher than grade 4), lack of sensitization and depigmentation of the skin, antimicrobial activity when using one concentration of the working solution against bacteria, highly resistant mycobacterium tuberculosis, poliomyelitis viruses, fungi of the genus andida and Trichophyton.

Ortho-phenylphenol (1,1-biphenyl-2-ol), ortho-benzyl-para-chloro-phenol (5-chloro-2-hydroxydiphenylmethane) are slightly soluble in water. The solubility in water of ortho-phenylphenol is 0.7 g / L or 0.07% [1] and ortho-benzyl-para-chlorophenol 0.007 g / L or 0.0007% [2], and to achieve the antimicrobial effect, it is necessary to obtain aqueous solutions with a high weight content of components. In order to increase the antimicrobial activity of working solutions, it is necessary to achieve good solubility of substances in the aquatic environment. In order to visually assess the washing effect and the absence of cloudy streaks on surfaces, it is necessary to obtain transparent solutions.

The toxicity of ethyl alcohol is much less than isopropyl alcohol, and the lowest toxicity in the series of glycols is propylene glycol.

The introduction of propylene glycol and ethyl alcohol into the composition allows one to increase the solubility and stability of ortho-phenylphenol and ortho-benzyl-para-chloro-phenol in aqueous solutions.

The proposed disinfecting washing composition allows to obtain clear aqueous solutions when diluted to 3.0% of the preparation with a concentration of ortho-phenylphenol of 0.09% and ortho-benzyl-para-chlorophenol - 0.087%.

A significant difference between the proposed disinfectant detergent composition based on ortho-phenylphenol and ortho-benzyl-para-chloro-phenol is the introduction of low-toxic propylene glycol and ethyl alcohol as solvents and stabilizers of aqueous solutions, in combination with lauryl sulfate, as a detergent component, providing a low toxicity of the composition, good solubility of ortho-phenylphenol and ortho-benzyl-para-chloro-phenol in aqueous working solutions at concentrations from 0.5% to 3.0% and the necessary antimicrobial effect.

The proposed composition contains (% by weight)

Ortho-phenylphenol - 3.0-3.5%

Ortho-benzyl-para-chloro-phenol - 2.6-3.2%

Propylene glycol - 60-70%

Ethyl alcohol - 5-10%

Lauryl sulfate - 10-15%

Water - 5-10%

The combination of ortho-phenylphenol and ortho-benzyl-para-chloro-phenol with low toxicity solvents is propylene glycol, ethanol and the detergent component lauryl sulfate is sufficient to obtain a disinfecting detergent composition that allows you to obtain the necessary antimicrobial effect, including against the most resistant pathogens of mycobacterium tuberculosis, Polio viruses, Candida fungi and Trichophytons, which has minimal toxicity to patients and staff when processing hard surfaces.

Example.

To obtain the proposed disinfectant washing composition, the following composition of ingredients (% by weight) was selected:

Ortho-phenylphenol - 3.4%

Ortho-benzyl-para-chloro-phenol - 2.9%

Propylene glycol - 68.85%

Ethyl alcohol - 9%

Lauryl sulfate - 10%

Water - 5.85%

Tests of the proposed disinfectant detergent composition were carried out in accordance with the guidelines "Methods of testing disinfectants to assess their effectiveness and safety", Ministry of Health of the Russian Federation, Moscow 1998 and "Regulatory indicators of safety and effectiveness of agents to be monitored during mandatory certification" No. 01-12 / 75-97.

Working solutions for tests were prepared on drinking tap water at room temperature with a dilution of 0.5%, 1%, 2%.

The concentration of active substances in working solutions is presented in table 2.

table 2 The concentration of the working solution,% Substance action The concentration of active substances,% 0.5 Ortho-phenylphenol 0.017 Ortho-benzyl-para-chloro-phenol 0.0145 1,0 Ortho-phenylphenol 0,034 Ortho-benzyl-para-chloro-phenol 0,029 2.0 Ortho-phenylphenol 0,064 Ortho-benzyl-para-chloro-phenol 0.058

In order to determine the microbiological activity, the following test objects were used: linoleum, metlakh tiles, plastic, glass, vinyl leather, oil-painted wood, metal, tile, rubber mats.

The following strains were used as test microorganisms:

E. coli (strain 1257), St.aureus (strain 906), Pseudomonas aeruginosa (strain ATCC-27853), Candida albicans (strain 15), Trichophiton gypseum, Mycobacterium B5, Poliovirus type 1 (vaccine strain LSc 2 ab).

To simulate organic contamination, 40% inactivated horse serum was used.

A daily suspension of microorganisms was applied to the surface of the test objects, dried and treated by wiping with a sterile cloth, abundantly moistened with one of the working solutions.

The criterion for the effectiveness of surface disinfection is for bacteria and fungi at least 99.99-100%, viruses 100% culture death (see table 3-7).

Table 3
Efficacy against E. coli (strain 1257), St. aureus (strain 906), Pseudomonas aeruginosa (strain ATCC-27853) Disinfection objects The concentration of the drug,% Efficiency,% The method of disinfection Test surfaces: Metlakh tile, linoleum, glass, oil-painted wood, plastic, vinyl leather 0.5 99.99-100 Wiping 1,0 99.99-100 2.0 99.99-100 0.5 99.99-100 Double rubbing with an interval of 15 min. 1,0 99.99-100 2.0 99.99-100 Tile with pre-applied and dried 40% horse serum 0.5 99.99-100 Wiping 1,0 99.99-100 2.0 one hundred 0.5 99.99-100 Double rubbing with an interval of 15 min. 1,0 99.99-100 2.0 one hundred

Table 4
Efficacy against Mycobacterium B5 Disinfection objects The concentration of the working solution,% (for the drug) Efficiency% The method of disinfection Test surfaces: 0.5 one hundred Double rubbing with an interval of 15 min. Metlakh tile, 1,0 one hundred linoleum, glass, wood, oil-painted, plastic, vinyl leather 2.0 one hundred Tile with pre-applied and dried 40% horse serum 0.5 one hundred Double rubbing with an interval of 15 min. 1,0 one hundred 2.0 one hundred Table 5
Efficacy against Candida albicans (strain 15) Disinfection objects The concentration of the working solution,% (for the drug) Efficiency% The method of disinfection Test surfaces: 0.5 99,99 Double rubbing with an interval of 15 min. Metlakh tile, 1,0 one hundred linoleum, glass, wood, oil-painted, plastic, vinyl leather 2.0 one hundred Tile with pre-applied and dried 40% horse serum 0.5 99,99 Double rubbing with an interval of 15 min. 1,0 one hundred 2.0 one hundred

Table 6
Efficacy against Trichophiton gypseum Disinfection objects The concentration of the working solution,% (for the drug) Efficiency% The method of disinfection Test surfaces: 0.5 one hundred Double rubbing with an interval of 15 min. Metlakh tile, 1,0 one hundred linoleum, glass, wood, oil-painted, plastic, vinyl leather 2.0 one hundred Tile with pre-applied and dried 40% horse serum 0.5 one hundred Double rubbing with an interval of 15 min. 1,0 one hundred 2.0 one hundred Rubber mats 1,0 one hundred Wipe or dive 2.0 one hundred Table 7
Efficacy against Poliovirus type 1 virus (vaccine strain LSc 2 ab) Disinfection objects The concentration of the working solution,% (for the drug) Efficiency% The method of disinfection Test surfaces: 1,0 one hundred Wiping Metlakh tile, linoleum, glass, oil-painted wood, plastic, vinyl leather 2.0 one hundred Tile with pre-applied and dried 40% horse serum 1,0 one hundred Double rubbing with an interval of 15 min. 2.0 one hundred

The proposed disinfectant washing composition, as can be seen from tables 2-7, has microbiological activity against a wide range of bacteria, Mycobacterium tuberculosis, Polio virus, Candida and Trichophyton fungi in any concentration of the working solution equal to or more than 1%, which for active substances is for ortho-phenylphenol - 0.034% and ortho-benzyl-para-chloro-phenol 0.029%.

Tests of the toxic and sensitizing effect of the proposed composition showed that with a single application, for example, rabbit skin working solutions from 0.5% to 2% concentration did not have a local irritant effect. Eye contact does not damage the cornea. A working concentration of 0.5% of the proposed composition does not cause any reaction of the mucous membrane of the eye and cornea. Tests of the proposed composition for a sensitizing effect using Freund's adjuvant and Hanks solution, for example, on white mice showed a reaction index of 1.47%, which is below the acceptable rating level (up to 5%) and indicates the absence of a sensitizing effect. Skin pigmentation was not detected. When the proposed composition was introduced into the stomach of rats in a dose of up to 6000 mg / kg, the animals did not die within 14 days. Application of the proposed composition to the skin of mice at a dose of 2500 mg / kg did not lead to the death of animals. Tests for inhalation hazard in saturating concentrations of the proposed composition did not lead to a change in spontaneous-motor activity, vertical motor activity and a mink reflex. This indicates that the proposed composition belongs to the 4th class of low-hazard substances with different routes of entry of substances according to GOST 12.1.007-76.

The technical effectiveness of the proposed invention consists in obtaining a disinfecting detergent composition having sufficient solubility and transparency of aqueous solutions, belonging to the class of low-hazard substances, without sensitization and depigmentation of the skin, without a sharp unpleasant odor, and having activity when using one of several concentrations of the working solution in against the most resistant microorganisms, such as mycobacterium tuberculosis, polio virus, fungal infections tion, which allows for complete reliable disinfection of objects in the absence of harmful effects on humans.

Sources of information used:

1. Safety date sheet in accordance with 2001/58 / EC Nipacid OPP. Clariant

2. Safety date sheet in accordance with 2001/58 / EC Nipacid BCP. Clariant

3. US patent No. 3824190, IPC C 11 D 3/48.

4. US patent No. 4157977, IPC C 11 D 3/48, 7/08.

5. REREGISTRATION ELIGIBILITY DECISION. ORTHO-BENZYL-P-CHLOROPHENOL. LIST B. CASE 2045. ENVIRONMENTAL PROTECTION AGENCY. OFFICE OF PESTICIDE PROGRAMS. SPECIAL REVIEW AND REREGISTRATION DIVISION.

6. Screening for occupational vitiligo in workers exposed to hydroquinone monomethyl ether and to paratertiary-amyl-phenol. O'Sullivan JJ, Stevenson CJ. Br J Ind Med., 1981 Nov; 38 (4): 381-3.

7. Para-tertiary-AmyIphenol. Toxicity profile. BIBRA Toxicology International (1990) 3p.

8. Material Safety date sheet. GLYCOLIC ACID (68-72%). MSDS Number: G6820. Date: 02/12/04.

Claims (2)

1. A disinfecting washing composition containing as ingredients ortho-phenylphenol, ortho-benzyl-para-chloro-phenol and water, characterized in that it additionally contains propylene glycol, ethyl alcohol, lauryl sulfate, in the following ratios of components, wt.% : Ortho-phenylphosphhenol 3.0-3.5 Ortho-benzyl-para-chloro-phenol 2.6-3.2 Propylene glycol 60.0-70.0 Ethanol 5.0-10.0 Lauryl sulfate 10.0-15.0 Water 5.0-10.0 2. The disinfecting washing composition according to claim 1, characterized in that the concentration of aqueous working solutions is from 0.5 to 3.0%.