RU2242999C1 - Method for treating secondary immunodeficiency - Google Patents

Abstract

FIELD: medicine, immunology.

SUBSTANCE: the present innovation deals with immunotherapy due to introducing immunotropic preparations lymphotropically due to subcutaneous paranodular injection being distally against cervical, axillary, inguinal lymph nodes from both sides and, also, into points of an episternum and under sternal xiphoid process successively per 1 injection daily at a single dose being equal to one third - one fifth of average daily therapeutic dose, course should last for 8 d. The method provides sanitation of the main lymph nodes and thymus due to developing high local concentrations while applying less doses of immunotropic preparations.

EFFECT: higher efficiency of therapy.

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Description

The invention relates to medicine and can be used to treat patients with secondary immunodeficiencies, for example, after radiation exposure, for chronic infectious diseases, for oncological diseases, for chemotherapy, etc.

There is a method of treating patients with similar immunological conditions when, according to the immuno-diagnostic data, immunotherapy is carried out using immunotropic drugs (Khaitov A.V., Pinegin B.V. Clinical immunology // Practicing physician. 1997, No. 9 (2), p. .9).

The disadvantages of this method are the following: long periods of treatment, the achieved result is short. Therefore, the duration of treatment increases and hence the course cost of therapy increases.

The invention is aimed at solving the problem: reducing treatment time, achieving a high and lasting effect in the treatment of secondary immunodeficiency.

These tasks are achieved by creating long-term and high concentrations of immunotropic pharmacological agents in the field of the main groups of lymph nodes and thymus, which leads to their rehabilitation and restoration of immunological functions. This is achieved by paranodular administration of the drug distal from the peripheral groups of lymph nodes, as well as by the arm and xiphoid process of the sternum, alternately in a single dose equal to 1 / 3-1 / 5 of the average daily therapeutic dose, 1 time per day, for 8 days.

At the same time, sanitation of the lymph nodes is achieved and their immunotropic functions are increased, which at the level of the organism as a whole leads to a fast, high immunomodulating effect. Through the upper and lower sternal points stimulate the function of the thymus, as well as sanitize the lymph nodes of the mediastinum.

The method is as follows. Before administration, a single dose of an immunotropic drug equal to 1 / 3-1 / 5 of the average daily therapeutic dose is diluted in 10 ml of physiological saline or 0.25% novocaine solution. The medicine is administered paranodularly, 15 mm distal from the group of lymph nodes using a dispenser, for example, "Cliff-1", at a speed of 40 ml per hour. The needle is inserted to a depth of 4-5 mm after appropriate skin treatment. The sequence of injections is as follows. The first day is the area of the mastoid process on the left. The second day - the injection site in the area of the mastoid process on the right. The third day - sanitation of axillary lymph nodes on the left, on the fourth day - on the right. On the fifth day, paranodular lymphotropic injection of the inguinal lymph nodes on the left, on the sixth day, on the right. On the seventh day, the medicine is administered behind the hilt of the sternum, on the eighth day, an injection under the xiphoid process. A course of 8 sessions of 1 per day without a break.

Examples of specific performance.

Example 1

Patient K., 44 years old, suffered from furunculosis for the past six months. During this time, surgeons opened up to 45 boils in various parts of the body. From the anamnesis: participant in the aftermath of the Chernobyl accident. In a general blood test, anemia of the first degree and leukopenia (leukocytes up to 2 thousand in 1 ml), according to the immunogram of inhibition of cellular immunity.

Treatment: lymphotropic, paranodularly administered T-activin in a single dose equal to 1/3 of the average daily therapeutic dose, 1 time per day, for 8 days. In the area of the cervical lymph nodes on the left and right, axillary and inguinal areas on the left and right, as well as on the arm and xiphoid process of the sternum, diluting the medicine with 10 ml of saline at a speed of 40 ml per hour. Immediately after a course of blood leukocytosis, up to 8.5 thousand in ml. the absence of recurrence of furunculosis within 3 years (observation period to the present), blood leukocytes from 3 to 4.5 thousand in 1 ml for the observed period in control studies.

Example 2

Patient C., 16 years old, was operated on for a nodal retrosternal form of lymphogranulomatosis. After the operation, the patient was sent to the regional oncology clinic for chemotherapy. For the treatment of secondary immunodeficiency (the diagnosis was made after an examination for immunodiagnostics) and for the prevention of side complications from chemotherapy, glutoxim 3% was selected. Its 1/5 of the average daily therapeutic dose was diluted in 10 ml of a 0.25% solution of novocaine and was administered 1 time per day at a rate of 40 ml per hour. On the first day, under the mastoid process on the left, the second day on the right, the third day, the axillary region on the left, the fourth day on the right. On the fifth day, the left groin, on the sixth - paranodularly to the right inguinal lymph nodes. On the seventh day - for the hilt of the sternum and on the eighth day - under the xiphoid process. Even with chemotherapy, all tests returned to normal. Before treatment, leukocytosis is 15 thousand per ml, lymphocytes - 62%, after treatment leukocytes - 8.5 thousand ml, lymphocytes - 32%. During the second course, chemotherapy, also the second course of glutoxim according to this technique.

Example 3

Patient B., 23 years old, diagnosis: chronic urogenital chlamydia, generalized form. It was treated for a long time without result. In the period of conditional remission, the patient was treated with cycloferon. The medicine in 1/4 of the average daily therapeutic dose was diluted in 10 ml of saline, once a day. For eight days, cervical lymph nodes were scanned on the left and right, axillary and inguinal left and right, and medicine was also administered by the arm and under the xiphoid process of the sternum. Subjectively, the patient has a clear improvement, the titer for chlamydial antigen decreased from 1: 320 to 1:40.

The positive effect of using the proposed method is to increase the effectiveness of therapy by sanitizing the main groups of lymph nodes and thymus with an immunotropic drug, which leads to an early, high, long-term therapeutic effect, ease of administration - 1 time per day for 15 minutes, saving expensive pharmaceuticals.

Claims (1)

A method of treating secondary immunodeficiency using immunotherapy, characterized in that the immunotropic drugs are administered lymphotropically by subcutaneous paranodular injection distally to the cervical, axillary, inguinal lymph nodes from two sides, as well as to the points behind the arm and under the xiphoid process of the sternum, one injection per day, in a single dose equal to 1 / 3-1 / 5 of the average daily therapeutic dose, 8 days course.