RU2240839C1 - Device having biologically active coating for draining and applying local drug therapy in the cases of visceral indications in surgery, proctology and gynecology - Google Patents

Abstract

FIELD: medical engineering.

SUBSTANCE: device has hollow perforated form-generating element manufactured as revolution body. Napkin from hydrophilic textile fabric is fixed on external part of the element. At least one layer of complex produced on basis of biologically active substance and biocompatible biodegradable polymer. Napkin ends are bent inside of the form-generating element and fixed by means of rings from elastomers permitted for use in medical practice.

EFFECT: enhanced effectiveness of treatment; low cost; prolonged therapeutic activity.

8 cl, 2 dwg

Description

The invention relates to medicine, in particular to devices and devices for the treatment of cavity diseases, especially proctologic (hemorrhoids, proctitis, anal fissures), gynecological (erosion, colpitis, vulvovaginitis), as well as active drainage in surgery.

A drainage device is known that contains a flexible polymer tube, with a synthetic thread attached to its working part, extended into the hole of the tube, and having two longitudinal parallel slots forming a flap (RU C1, 2065309, A 61 M, 08.20.96).

However, this device provides the flow of drugs only through its internal cavity, and when it is closed with pore decomposition products from the affected area, the flow of drugs stops.

A drainage device is known that makes it possible to reduce postoperative mortality by concentrating the antibiotic outside the drainage and holding it for a long time along the bile duct wall using permanent magnets and a magnetic screen mounted on the endobiliary drainage (RU 2098146 C1, MKI A 61 M 31 / 00, 12/10/97).

Allowing both drainage of the lesion and prolonged treatment with drugs, this device, however, due to the presence of magnets and a magnetic screen, is quite difficult and cumbersome to perform.

Known drainage device with a biologically active coating for drainage and prolonged local drug therapy for abdominal indications in surgery, proctology, gynecology, adopted as a prototype, which is a hollow perforated shaping element in the form of a body of revolution, on the outside of which a napkin made of hydrophilic textile material is fixed, with a complex deposited on it based on a biologically active substance and a biocompatible biodegradable polymer equipped with a fixative input located on the opposite input end of the device, and the ends of the napkins on the input end of the device are fixed with a safety thread, and the ends of the napkins on the opposite side are fixed with a latch (RU, application No. 2001127293, MKI A 61 L 15/64, pol. .2002).

However, while allowing prolonged delivery of drugs to the area of abdominal diseases while ensuring the removal of decay products from the pathological focus, this device is laborious to manufacture, low-tech and has insufficient passability for gas removal and removal of the lead-in end.

The present invention solves the problem of creating a more efficient, easy-to-manufacture and technologically advanced drainage device with a prolonged therapeutic effect, with good through patency for removal of discharge and less traumatic effect when used.

This problem is solved in that in a device with a biologically active coating for drainage and prolonged local drug therapy, which is a hollow perforated form-forming element in the form of a body of revolution, on the outside of which a napkin made of hydrophilic textile material is applied with at least one layer of a complex based on a biologically active substance and a biocompatible biodegradable polymer, new is that the ends of the napkin are bent inward to form its element and fixed inside it with rings of elastomers.

Such a fastening of a napkin with a prolonged therapeutic effect on the forming element allows not only to drain with direct contact of the biologically active substance with the disease site and its dosed prolonged intake, but also makes the device itself less traumatic and simpler to manufacture and use. At the same time, the efficiency of the device is increased due to the good through passability of the discharge during its removal.

It is most convenient to carry out the forming element from elastomers permitted in medicine. Currently, the most common ones are silicone rubber, polyvinyl chloride or medical rubber.

For a more complete sorption of detachable inside the forming element can be located filler.

Currently, the most commonly used:

as a hydrophilic textile material, which is the basis of a prolonged-action napkin, a woven or non-woven fabric of cotton, viscose, or a combination thereof;

as a biocompatible biodegradable polymer, carboxyl methyl cellulose, alginate or polysaccharide.

Biologically active coating, depending on the nature and degree of the affected area, may contain antimicrobial and / or hemostatic and / or anesthetic and / or antioxidant and / or wound healing agents.

To improve drainage, the napkin can be perforated.

The supply of the device at the output end with a fixing element made of elastic material allows you to control the depth of its penetration into the affected area and insure against the failure of the device into the affected cavity. The shape of this element can be any corresponding to the above function.

An output thread is secured from the output end of the forming element, insuring its removal from the affected cavity, which can be located both inside and outside the forming element.

The inventive design of the device shown in the drawing, where Fig.1 and 2 shows a General view of the device, a longitudinal section (options).

The device is made in the form of a forming element in the form of a hollow cylinder 1. On the outer part of the hollow cylinder 1 a biologically active coating is fixed, consisting of a napkin 2 of a textile material with hydrophilic properties with a complex applied on it based on a biologically active substance and a biocompatible biodegradable polymer, the ends being wipes 2 are fixed inside the hollow cylinder 1 using rings 3 of elastomers. At the output end of the hollow cylinder 1, a fixing element 4 made of an elastic material authorized in medicine can be fixed

A filler 5 (FIG. 2) can be located inside the cylinder bed of the cylinder 1, and an output thread 6 (located inside FIG. 1 or outside of FIG. 2) of the hollow cylinder 1 can be fixed on the side of its output end.

The proposed device operates as follows. Before use, the napkin 2 is moistened, and the device is inserted into the inflamed cavity, in the case of proctologic diseases, it is advisable to lock the element 4. The fixing element 4 prevents the entire device from falling into the affected area.

In the case of the treatment of gynecological diseases after wetting the wipes 2, the device is inserted into the vagina completely, leaving only the output thread 6. This ensures the most complete contact of the therapeutic substance with the affected area.

The device can provide both passive drainage with the therapeutic effect provided by the biologically active coating, and in the mode of active drainage with a connection to the circuit, which provides the supply of additional biologically active solutions and drugs from the outside.

In case of abundant discharge, a forming element is used in the form of a hollow cylinder filled with a filler for sorption of the detachable 5 (granules, gauze, cotton, non-woven fabric). Removing the device using the output thread 6 or the fixing element 4 is carried out depending on the nature of the disease. With abundant discharge at least 2-3 times a day, in the absence of discharge, depending on the physiology of the patient, since the biologically active substance from the napkin 2, impregnated with the treatment substance, is delivered as the polymer containing it biodegradation, i.e. about 3 days.

This ensures the longest possible contact of medicinal substances with the pathological focus, which helps to reduce the time of its treatment.

The effectiveness is confirmed by the use of an experimental batch of the devices described above for the treatment of hemorrhoids, anal fissures, active drainage of cavities in the postoperative period under stationary conditions.

Claims (8)

1. A device with a biologically active coating for drainage and prolonged local drug therapy, which is a hollow perforated shaping element in the form of a body of revolution, on the outer part of which is fixed a napkin made of hydrophilic textile material with at least one layer of the complex on it the basis of a biologically active substance and a biocompatible biodegradable polymer, characterized in that the ends of the napkin are bent inside the forming element and fixed inside and him with rings of elastomers. 2. The device according to claim 1, characterized in that the forming element is made of silicone rubber, or polyvinyl chloride, or medical rubber. 3. The device according to claim 1, characterized in that inside the forming element there is a filler for sorption of the detachable. 4. The device according to claim 1, characterized in that as a hydrophilic textile material is a woven or non-woven fabric made of cotton, viscose or a combination thereof. 5. The device according to claim 1, characterized in that the biocompatible biodegradable polymer is represented by a polysaccharide, or carboxymethyl cellulose, or sodium alginate. 6. The device according to claim 1, characterized in that the biologically active coating contains an antimicrobial and / or hemostatic and / or anesthetic and / or antioxidant and / or wound healing agent. 7. The device according to claim 1, characterized in that the napkin is perforated. 8. The device according to claim 1, characterized in that at the output end of the device is fixed a locking element made of an elastic material in the form of a cone, ring or outlet tube.

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