RU2134585C1 - Biologically active food additive "korrida" for losing the habit of smoking - Google Patents

Abstract

FIELD: medicine. SUBSTANCE: additive is a mixture of vegetable powders and auxiliary ingredients necessary for preparing tabletted form. EFFECT: organism clearance from harm substances accumulated on tobacco smoking. 2 cl

Description

 The invention relates to food industry and medicine, namely to biologically active food additives, and can be used to facilitate weaning from tobacco smoking and to cleanse the body of harmful substances accumulated in this case.

 Known medicines for facilitating smoking cessation are Tabex, Lobesil, Gamibazin, manufactured by the pharmaceutical industry in the form of tablets (gamibazin is also available in the form of chewing gum) / Mashkovsky M.D. Medicines Kharkov. Torsin, 1997, v. 1.2 /.

 However, the disadvantage of these funds is the use as active principle extracted from plants chemical potent (toxic) substances. In particular, Tabex includes the cytisine alkaloid, Lobesil the lobelin alkaloid, and Hamibazine the anabazine alkaloid. The use of such substances imposes significant restrictions on the possibility of using drugs based on them. So the use of tablets with lobelin, cytisine and anabazine is contraindicated in case of exacerbation of peptic ulcer of the stomach and duodenum, organic changes in the cardiovascular system, with severe atherosclerosis and hypertension, bleeding from large vessels, pulmonary edema. Treatment should be carried out as directed and under the supervision of a physician. In case of an overdose, nausea, vomiting, dilated pupils, increased heart rate, increased blood pressure, weakness, irritability, dizziness are possible, which requires stopping the drug.

 These factors significantly narrow the contingent of individuals to whom these treatments can be recommended. In addition, the above-mentioned features of the action of drugs, a sudden cessation of smoking create an unpleasant psychological background for treatment, cause a feeling of discomfort, a state of stress, which reduces the mood for smoking cessation.

 Medicines for smoking cessation on a natural plant basis have a more gentle effect. Such means include "Antic" according to the patent of the Russian Federation N 2066196, M.cl. A 61 K 35/78 B.I. N 25, 1996, adopted by most of the similar features as a prototype. The tool includes two compositions of collections of medicinal plants for administration at different times of the day. One collection (for morning use) contains equal amounts of rhizome of calamus swamp, grass of knotweed, leaves of nettle, large plantain leaves, horsetail grass, Icelandic moss, licorice root, mallow forest root, cedarweed grass, pine grass, sapling grass, and inflorescences of a yellow fly - the rest. The second collection (for evening use) contains in equal amounts the blue rhizome of cyanosis blue, eucalyptus leaves, marsh rosemary grass, common goldenrod grass, lavender grass, Marshal thyme grass, angelica medicinal leaves, peppermint grass, peppermint grass - the rest .

For the practical use of the fees, the plants included in them are crushed to a particle size of 500-750 microns, 200 mg of the resulting mixture is poured with 50 ml of boiling water, heated to 100 ^o C and insisted for 20-30 minutes. Then the infusion is cooled and taken as tea 30 minutes before meals in the morning and in the evening, 1 time per day of each collection for 3-4 months. The composition "Antinic" eliminates craving for nicotine and significantly reduces the manifestation of nicotine withdrawal symptoms, eliminates cough, reduces the amount of sputum and other manifestations of chronic bronchitis of smokers.

 The disadvantages of the known drug for smoking cessation are as follows.

 It, along with the plants described in Pharmacopoeia XI, contains ingredients that are not included in it, which greatly complicates the certification of drugs and food additives with their use by official medical authorities and the food industry, since this requires lengthy tests and the creation of relevant regulatory documentation . In this regard, at present, the use of such plants is limited mainly to traditional medicine.

 Fees include little-known herbal ingredients, the description of which is practically not found even in the fundamental reference books on medicinal plants and traditional medicine: scaffold, cistus papaver, jujube, Bunge, thyme Marshall, which makes it difficult to assess their area, resources, medicinal properties and practical feasibility of use.

 In the "Antique" contains plants that differ in varying degrees of toxicity: goldenrod, ledum, ram. In the reference manuals there are indications that the use of goldenrod requires caution and accurate dosage. Ledum contains essential oil, which can cause inflammation of the mucous membrane of the gastrointestinal tract; cases of poisoning people with rosemary are known. Baranets is used in scientific and traditional medicine to combat alcoholism and tobacco smoking, however, treatment should be carried out only in a hospital under close medical supervision; independent use is not allowed. Thus, the use of these plants can only be justified in medicines when they are used in a hospital, but not in food additives that provide a gentle effect in home use.

 A disadvantage of the known agent is the powder form, which in some cases creates significant inconvenience in its use, storage, dosing. The drug is impossible or difficult to use in public places, when traveling by transport, etc. It is difficult to implement the process of dispensing a powder of 200 mg without the presence of special scales.

 A large number of ingredients complicates the preparation of fees, and the need for daily intake of different fees (morning and evening) for 3-4 months psychologically depresses the patient with monotony and possible confusion.

 The noted disadvantages make it difficult to organize mass production of an easy-to-use and safe drug to facilitate smoking cessation.

 The objective of the invention is to create a biologically active supplement that is accessible for wide industrial development, which facilitates smoking cessation, is convenient for use in everyday life, has high therapeutic efficacy, does not require medical supervision, and creates a clear psychological attitude in the consumer on the appropriateness and possibility of quitting smoking without experiencing at the same time, especially unpleasant or painful sensations, ensuring the gradual adjustment and adaptation of the body to a new condition the melting of "non-smoking" both at the physiological and sensory levels.

 The result achieved by using the invention is such a selection of plant and auxiliary ingredients for a biologically active additive that provides high smoking cessation; in giving the biologically active additive additional therapeutic properties that contribute both to the release of the body from harmful tobacco products, and to the use of these properties for the treatment of diseases associated with smoking and other pathologies; in giving the dietary supplement a consumer form, which ensures, on the one hand, the manufacturability of its mass industrial production, and, on the other hand, the convenience of dosage, storage, and reception under any patient’s conditions: at work, on trips in transport, in public places, etc. .d.

 The essence of the invention lies in the fact that a biologically active food supplement for smoking cessation, including rhizomes of calamus marsh and peppermint leaves, additionally contains microcrystalline cellulose, refined sugar and calcium stearate in the following ratio of ingredients, wt.%: Marsh calamus (rhizomes) - 8.0 - 12.0; peppermint (leaves) - 3.0 - 4.0; refined sugar (powder) - 34.0 - 38.0; calcium stearate - 0.3 - 0.5; microcrystalline cellulose - the rest. The additive is made in tablet form from a mixture of powders of the used plant composition and auxiliary ingredients, while the particle size of the powders is less than 500 microns.

 The proposed biologically active food supplement "Bullfight" for weaning from smoking includes herbal and auxiliary ingredients that have the following properties.

 Marsh calamus is a spicy plant with a wide range and significant resources that can satisfy the demands of the food and medical industries (listed in the Gosfarmakopeia). It has been widely used since ancient times in folk (and now scientific) medicine in many countries, as well as in the food industry in the manufacture of flavored perfumes, liquors, candied fruits, seasonings, etc. The spectrum of medicinal properties of calamus is very wide. Calamus rhizomes are considered one of the best means for stimulating appetite and improving digestion. With inhibition of the central nervous system, calamus is used as a tonic. It has a bactericidal, anti-inflammatory, analgesic, antipyretic, diuretic, choleretic, expectorant, lowering blood pressure effect. The roots of calamus treat gastrointestinal diseases (chronic gastritis, colitis, flatulence, diarrhea of various origin, peptic ulcer of the stomach and duodenum); urolithiasis and cholelithiasis, diseases of the liver and biliary tract, inflammation of the bladder; broncho-pulmonary diseases (bronchitis, bronchial asthma, pneumonia); menstrual irregularities, sexual weakness. Air is recommended to be taken as a means to improve vision and hearing, chew with periodontal disease, toothache, epidemics of influenza, cholera, typhus, and external are used to treat wounds, suppurating ulcers, skin lesions.

 Peppermint - is widely used in the food industry as a flavoring additive. Mint is also widely used in medicine (introduction to the Gosfarmakopeia). It acts as an antispasmodic, sedative, choleretic, diuretic, hemostatic, improves digestion, and has anti-inflammatory effects. It is used for hypertension, insomnia, liver diseases, for cramping in the stomach, intestines, gastritis, enterocolitis, flatulence, migraine, to improve appetite and cardiac activity. It is used for nausea, vomiting, stomatitis, pharyngitis, angina pectoris, atherosclerosis, and respiratory diseases.

 Microcrystalline cellulose - is a concentrate of plant fiber. In its properties, it is close to natural cellulose, which is found as a natural component in food products. Its use is authorized by the Joint FAO / WHO Expert Committee on Food Additives. It has been established that passing through the alimentary canal, water-insoluble microcrystalline cellulose has a diverse mechanical and sorption effect. Mechanical irritation of the mucous membrane stimulates the motor function of the intestine, accelerates the intensity of the physiological renewal of its mucous membrane. An increase in stool volume due to moisture absorption reduces concentration and shortens the interaction of carcinogens with the surface of the mucous membrane. The sorption properties of microcrystalline cellulose are manifested in the fact that, in addition to water, its fibers bile bile acids and cholesterol on their surface, which form potential carcinogens. Throughout the gastrointestinal tract, they also absorb substances harmful to the body, toxins, radionuclides, heavy metals, and others. Microcrystalline cellulose reduces blood sugar, which makes it possible to use it in the complex treatment of diabetes mellitus. For therapeutic and preventive purposes, microcrystalline cellulose is recommended for obesity, atherosclerosis, coronary heart disease, gastroenterological diseases, for the prevention and suspension of growth of neoplasms, the formation of stones in the gall bladder, kidneys, etc. In addition, it serves as an excellent filler in the manufacture of tablets, improving their manufacturability molding.

 Refined sugar (powder) - is a food ingredient that improves taste, contributes to the rapid absorption of active ingredients of biologically active additives already in the oral cavity.

 Calcium stearate is an auxiliary substance approved for use in the food and pharmaceutical industries, which improves the manufacturability of tablet formation.

 A distinctive feature of the biologically active additives "Corrida" in relation to the prototype is its implementation in tablet form from a mixture of powders of the proposed plant composition and auxiliary components. In this case, to obtain tablets of the desired quality according to the conditions of the technology, powders of ingredients are used, the particle sizes of which should not exceed 500 microns.

 The tablet form of a multicomponent composition has several advantages. Firstly, it is very convenient for taking the drug in any specific conditions of use: tablets can always be carried and taken at any time of the day on trips, in public places, etc. With prolonged maintenance therapy, this factor is of great importance. Secondly, tablets are convenient for storage and transportation, as they are packaged in a blister strip packaging made of polymer film, or in laminated paper, or plastic bottles.

 The methodology for the use of biologically active additives "Bullfight" is as follows. With severe tobacco dependence, up to 30 tablets can be taken during the day. If you want to smoke, put 1 tablet (0.5 g) under the tongue and hold it in your mouth, without swallowing, until completely resorbed. The resulting acute taste sensations suppress the desire to smoke and cause nausea when thinking about it. Usually after a few minutes the desire to smoke decreases or disappears completely. The next tablet is taken in the same way when the desire to smoke again arises. With a decrease in cravings for smoking, the interval between tablets is also increased. A person taking Corrida tablets and continuing to smoke does not get the usual feeling and satisfaction of a cigarette.

 With significant smoking experience (more than 10 years), the maximum weaning effect is observed with regular use of tablets for 5-7 weeks. At the same time, metabolic processes in the body are normalized and a steady aversion to tobacco smoke is produced. However, even in the absence of craving for smoking, it is recommended that you take at least 5 tablets of the drug per day for a while.

 In cases of "light" tobacco dependence, up to 10 Corrida tablets daily intake for 3-4 weeks is enough for the course of treatment.

 For those who do not smoke or have already quit smoking, the dietary supplement "Bullfight" is recommended as a therapeutic and prophylactic agent for various concomitant diseases. It can be used to treat peptic ulcer of the stomach and duodenum, gastroenteritis, with cholecystitis, hepatitis, urolithiasis, inflammatory processes of the oral mucosa (periodontal disease, glossitis, gingivitis, etc.), with cardiovascular diseases like antiarrhythmic, with sexual disorders in men and women, with diseases of the thyroid gland, such as tonic, restorative, anti-stress. anti-febrile and expectorant. In this case, take 1-2 tablets 4 times a day for 1.5-2 months in spring and autumn during periods of deterioration.

 There are no absolute contraindications to taking the drug. In case of hypersensitivity, you can reduce the dose by 2-3 times.

 Thus, unlike the prototype, the proposed drug is not a medicine, but a biologically active additive, which does not require medical prescription and control in the treatment of smoking. The preparation does not contain poisonous ingredients, requires a shorter course of treatment, has a convenient consumer form, and has advanced functionality that, in addition to facilitating smoking cessation, can be used to treat concomitant diseases. Taking the drug provides gradual weaning and is not associated with psychological and physiological overload. These factors make it advisable to organize a wide release of biologically active additives "Bullfight" for everyone who wants to give up a bad habit, regardless of gender, age and health.

 Currently, Corrida dietary supplement has been tested at the Institute of Nutrition of the Russian Academy of Medical Sciences (hygienic certificate N72-ЦГС-1130 dated November 28, 1996) and approved by the State Committee for Sanitary and Epidemiological Surveillance of the Russian Federation for the manufacture, sale and use as an anti-smoking agent (with anti-nicotine effect), as well as a therapeutic and prophylactic agent as a general strengthening, in case of gastrointestinal and catarrhal diseases.

Claims (1)

1. Biologically active food supplement for smoking cessation, including rhizomes of calamus marsh and peppermint leaves, characterized in that it additionally contains microcrystalline cellulose, refined sugar and calcium stearate in the following ratio of ingredients, wt.%:
Air marsh (rhizomes) - 8.0-12.0
Peppermint (leaves) - 3.0-4.0
Refined sugar (powder) - 34.0-38.0
Calcium stearate - 0.3-0.5
Microcrystalline Cellulose - Else
2. The additive according to claim 1, characterized in that it is made in tablet form from a mixture of powders of the used plant composition and auxiliary ingredients, while the particle size of the powders is less than 500 microns.