RU2125855C1 - Mustard plaster - Google Patents

Abstract

FIELD: medical engineering. SUBSTANCE: mustard plaster has two-sided fibrous base layer made of waterproof nonsoaking material. It is filled with mustard mass consisting of mustard powder and mixture of mustard cake and nuclei seeds ground up to size of 600-700 mcm in proportion of 9:1. Mustard plaster is divided into cells by seams. Cake is preferably not decontaminated, seed nuclei are preferably not degreased. EFFECT: improved hygiene and increased active time up to three years. 7 cl, 2 ex

Description

 The invention relates to the medical industry, to the production of irritating and distracting agents - mustard plasters, and can be used to prepare a dosage form in the form of sachets from cells.

 Known mustard [1], containing mustard powder, crushed kernels of mustard seeds and crushed fodder mustard cake with a fineness of not more than 500 - 600 microns, in the following ratio, wt. h: mustard powder 10 to 12; crushed kernels of mustard seeds 1 to 5; chopped fodder mustard meal 1 - 30.

 The disadvantage of this mustard is a short shelf life, not more than 1.5 years, not high hygiene, weak intensity of the therapeutic effect and rapidly decreasing pharmacological activity, due to decomposition under the influence of water vapor of the air and the environment during storage, since the cake and seed kernels are crushed - destroyed to a fineness of less than 600 microns, insufficient relative content of mustard cake, not exceeding 7 to 1 with respect to the content of mustard seed kernels in the composition of the mustard mixture, while fodder is used, i.e. bezvrezhenny - treated with saturated steam, bagasse, i.e. less active - glucoside with a reduced content - sinigrin.

 Known mustard [2], containing crushed to a size of 600 microns, the mass of kernels of mustard seeds and mustard fodder and food cake, with a ratio of components, wt. h: crushed mustard food meal 10 - 12; crushed kernels of mustard seeds 1 to 5; crushed mustard fodder cake 37 - 50, placed in bags of porous paper.

 Such a mustard plaster, although it has increased hygiene, retaining its healing properties for up to 2 years, however, the intensity of its therapeutic effect is insufficient, the pharmacological activity decreases during storage, under the influence of moisture and water vapor of air and the environment through the entire bilateral porous surface of the bags. In addition, when used, another disadvantage is the uneven distribution of mustard mass in the volume of the bag.

 Also known mustard [3], containing crushed mustard seed kernels crushed to 400 - 600 μm, placed on paper in the form of a bag, one side of which is made of porous paper impregnated with ascorbic acid.

 Such a dosage form of mustard, the carrier of the packet of which even when divided into cells, does not have a uniform distribution of the mustard mass in the volume of the packet, that is, the cells can have a different intensity of exposure when used, not enough controlled, - the use of a single mustard component - crushed to 400 microns fat-free cake, does not increase the shelf life, which in this case does not exceed 1.5 years and does not sufficiently increase the intensity of the treatment Vija.

 The creation on the basis of mustard mass of an effective balneological form of a medicinal product that is convenient to use, prevents the scattering of mustard mass and lumpiness, which has a qualitative and quantitative combination of mustard components that differ in the content of active substances - sinigrin glucoside and the myrosin enzyme, which retains an active pharmacological effect for a long time, is a task , the solution of which the invention is directed.

This is achieved by the fact that the mustard bags, made on a double-sided fiber substrate, are divided into cells with a uniform distribution of mustard mass, one side of which is made of waterproof porous paper, the other side has a waterproof coating, while the mustard mass consists of components, wt.%. :
Mustard Powder - 30 - 60
A mixture of ground mustard cake and mustard seed kernels in a ratio of 90:10 - 70-40
600 to 700 microns mustard cake is used, preferably unmediated, and 600 to 700 microns mustard seed kernels, preferably non-fat.

 As a result, the mustard plaster has increased hygiene while maintaining an active period of up to three years, the cellular form provides a snug fit and localization of the action of mustard when used, effective bactericidal, irritating and distracting balneological effects are achieved by changing the concentration and combination of the syngyrin glucoside contained in the used components and the enzyme myrosine, under the influence of which, when the mustard mass of the mustard is wetted Doi allocated mustard oils - esters of isothiocyanic acid.

Example 1
Mustard plaster is a bag measuring 12.5 x 8 cm, one side of which is non-wetting porous paper, the other is a paper-based material combined, divided by seams into 4 equal cells of a rectangular shape, filled with 4 g of mustard mass consisting of, wt. %: mustard powder - 60; crushed to a size of not less than 600 microns unreinforced mustard meal - 36; crushed to a size of not less than 600 microns of non-fat kernels of mustard seeds - 4.

 The ether content of allyl isothiocyanate is 0.046 g, and the mustard expiration date is more than three years.

Example 2
Mustard plaster - a bag, one side of which is non-wetting porous paper, the other side is laminated paper, 11 x 10 cm in size, divided by a heat-welded seam with a notch into cells of 4.5 x 4 cm in size, filled with 3 g of mustard mass, consisting of , wt.%: mustard powder - 30; crushed mustard cake to a size of not more than 700 microns - 63; crushed to a size of not more than 700 microns mustard seed kernels - 7.

 The ether content of allyl isothiocyanate 0.028 g, the shelf life of mustard is not less than three years.

 A fragment of a mustard-packet of three cells comes off the suture cut from the sachet, containing on average 0.020 g of allyl isothiocyanate ether, for localized placement of the dosage form on the body and mitigation of the irritating effect.

Claims (6)

1. Mustard, made on a double-sided fiber substrate in the form of closed sachets filled with mustard powder and ground kernels of mustard seeds and mustard cake, characterized in that the bags are divided into cells, contain in a 9: 1 ratio a mixture of ground mustard, crushed to a size of 600 - 700 microns oilcake and mustard seed kernels in the following ratio of components, wt.%:
Mustard Powder - 30 - 60
A mixture of mustard oilcake and mustard seed kernels - 70 - 40
2. Mustard according to claim 1, characterized in that at least one of the sides of the substrate is made of waterproof porous paper, the other side of the substrate is made of paper with a polymer coating or laminated.  3. Mustard according to claim 2, characterized in that the sachets are divided into cells by seams, preferably heat-sealed.  4. Mustard plaster according to claim 3, characterized in that the seam is embossed with a notch.  5. Mustard according to claims 1 and 3, characterized in that the mustard composition is evenly distributed in the cells.  6. Mustard according to claims 1 and 5, characterized in that the non-fat mustard cake is used.  7. Mustard according to claims 1 and 6, characterized in that non-fat kernels of mustard seeds are used.